Gutian Xiao

Title(s)Professor of Molecular Microbiology and Immunology
SchoolKeck School of Medicine of Usc
Address1333 San Pablo St.
Health Sciences Campus
Los Angeles CA 90033
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    Other Positions
    Title(s)DEI Director, Department of Molecular Microbiology and Immunology


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. PDLIM2 is a novel E5 ubiquitin ligase enhancer that stabilizes ROC1 and recruits the ROC1-SCF ubiquitin ligase to ubiquitinate and degrade NF-κB RelA. Cell Biosci. 2024 Jul 30; 14(1):99. Sun F, Xiao G, Qu Z. PMID: 39080804; PMCID: PMC11287889.
      View in: PubMed   Mentions:
    2. Critical and distinct roles of cell type-specific NF-κB2 in lung cancer. JCI Insight. 2024 Feb 22; 9(4). Sun F, Xiao Y, Shapiro SD, Qu Z, Xiao G. PMID: 38385745; PMCID: PMC10967404.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    3. Improving PD-1 blockade plus chemotherapy for complete remission of lung cancer by nanoPDLIM2. bioRxiv. 2024 Jan 09. Sun F, Yan P, Xiao Y, Zhang H, Shapiro SD, Xiao G, Qu Z. PMID: 37546791; PMCID: PMC10402062.
      View in: PubMed   Mentions: 1  
    4. Alveolar Macrophages Inherently Express Programmed Death-1 Ligand 1 for Optimal Protective Immunity and Tolerance. J Immunol. 2021 07 01; 207(1):110-114. Sun F, Li L, Xiao Y, Gregory AD, Shapiro SD, Xiao G, Qu Z. PMID: 34135059; PMCID: PMC8674373.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    5. PDLIM2 repression by ROS in alveolar macrophages promotes lung tumorigenesis. JCI Insight. 2021 03 08; 6(5). Li L, Sun F, Han L, Liu X, Xiao Y, Gregory AD, Shapiro SD, Xiao G, Qu Z. PMID: 33539325; PMCID: PMC8021114.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    6. Methods to Detect NF-κB Activity in Tumor-Associated Macrophage (TAM) Populations. Methods Mol Biol. 2021; 2366:213-241. Sun F, Qu Z, Xiao G. PMID: 34236641.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    7. Dual but not single PD-1 or TIM-3 blockade enhances oncolytic virotherapy in refractory lung cancer. J Immunother Cancer. 2020 05; 8(1). Sun F, Guo ZS, Gregory AD, Shapiro SD, Xiao G, Qu Z. PMID: 32461344; PMCID: PMC7254155.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    8. Causative role of PDLIM2 epigenetic repression in lung cancer and therapeutic resistance. Nat Commun. 2019 11 22; 10(1):5324. Sun F, Li L, Yan P, Zhou J, Shapiro SD, Xiao G, Qu Z. PMID: 31757943; PMCID: PMC6876573.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    9. NF-κB RelA renders tumor-associated macrophages resistant to and capable of directly suppressing CD8+ T cells for tumor promotion. Oncoimmunology. 2018; 7(6):e1435250. Li L, Han L, Sun F, Zhou J, Ohaegbulam KC, Tang X, Zang X, Steinbrecher KA, Qu Z, Xiao G. PMID: 29872577; PMCID: PMC5980414.
      View in: PubMed   Mentions: 22     Fields:    
    10. Isolation of Murine Alveolar Type II Epithelial Cells. Bio Protoc. 2017 May 20; 7(10). Sun F, Xiao G, Qu Z. PMID: 29082286; PMCID: PMC5659635.
      View in: PubMed   Mentions: 5  
    11. Murine Bronchoalveolar Lavage. Bio Protoc. 2017 May 20; 7(10). Sun F, Xiao G, Qu Z. PMID: 29082285; PMCID: PMC5659634.
      View in: PubMed   Mentions: 33  
    12. Myeloid STAT3 Promotes Lung Tumorigenesis by Transforming Tumor Immunosurveillance into Tumor-Promoting Inflammation. Cancer Immunol Res. 2017 03; 5(3):257-268. Zhou J, Qu Z, Sun F, Han L, Li L, Yan S, Stabile LP, Chen LF, Siegfried JM, Xiao G. PMID: 28108629; PMCID: PMC5334370.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    13. Interleukin-6 Prevents the Initiation but Enhances the Progression of Lung Cancer. Cancer Res. 2015 Aug 15; 75(16):3209-15. Qu Z, Sun F, Zhou J, Li L, Shapiro SD, Xiao G. PMID: 26122841; PMCID: PMC4537823.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    14. Systematic detection of noncanonical NF-κB activation. Methods Mol Biol. 2015; 1280:121-54. Qu Z, Xiao G. PMID: 25736747.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    15. Differential roles of STAT3 in the initiation and growth of lung cancer. Oncogene. 2015 Jul; 34(29):3804-3814. Zhou J, Qu Z, Yan S, Sun F, Whitsett JA, Shapiro SD, Xiao G. PMID: 25284582; PMCID: PMC4387125.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    16. NF-kappaB activation: Tax sumoylation is out, but what about Tax ubiquitination? Retrovirology. 2012 Sep 25; 9:78. Xiao G. PMID: 23009565; PMCID: PMC3470980.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    17. PDLIM2 restricts Th1 and Th17 differentiation and prevents autoimmune disease. Cell Biosci. 2012 Jun 25; 2(1):23. Qu Z, Fu J, Ma H, Zhou J, Jin M, Mapara MY, Grusby MJ, Xiao G. PMID: 22731402; PMCID: PMC3543335.
      View in: PubMed   Mentions: 24  
    18. Human T-cell lymphotropic virus: a model of NF-κB-associated tumorigenesis. Viruses. 2011 Jun; 3(6):714-49. Qu Z, Xiao G. PMID: 21743832; PMCID: PMC3131208.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    19. The tumor suppressor gene WWOX links the canonical and noncanonical NF-κB pathways in HTLV-I Tax-mediated tumorigenesis. Blood. 2011 Feb 03; 117(5):1652-61. Fu J, Qu Z, Yan P, Ishikawa C, Aqeilan RI, Rabson AB, Xiao G. PMID: 21115974; PMCID: PMC3318777.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    20. Epigenetic repression of PDZ-LIM domain-containing protein 2: implications for the biology and treatment of breast cancer. J Biol Chem. 2010 Apr 16; 285(16):11786-92. Qu Z, Fu J, Yan P, Hu J, Cheng SY, Xiao G. PMID: 20185823; PMCID: PMC2852914.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    21. DNA methylation-dependent repression of PDZ-LIM domain-containing protein 2 in colon cancer and its role as a potential therapeutic target. Cancer Res. 2010 Mar 01; 70(5):1766-72. Qu Z, Yan P, Fu J, Jiang J, Grusby MJ, Smithgall TE, Xiao G. PMID: 20145149; PMCID: PMC3003295.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    22. Human T-cell leukemia virus type I-mediated repression of PDZ-LIM domain-containing protein 2 involves DNA methylation but independent of the viral oncoprotein tax. Neoplasia. 2009 Oct; 11(10):1036-41. Yan P, Qu Z, Ishikawa C, Mori N, Xiao G. PMID: 19794962; PMCID: PMC2745669.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    23. PDLIM2 suppresses human T-cell leukemia virus type I Tax-mediated tumorigenesis by targeting Tax into the nuclear matrix for proteasomal degradation. Blood. 2009 Apr 30; 113(18):4370-80. Yan P, Fu J, Qu Z, Li S, Tanaka T, Grusby MJ, Xiao G. PMID: 19131544; PMCID: PMC2676091.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    24. SUMO1 modification of NF-kappaB2/p100 is essential for stimuli-induced p100 phosphorylation and processing. EMBO Rep. 2008 Sep; 9(9):885-90. Vatsyayan J, Qing G, Xiao G, Hu J. PMID: 18617892; PMCID: PMC2529344.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    25. Targeting autophagic regulation of NFkappaB in HTLV-I transformed cells by geldanamycin: implications for therapeutic interventions. Autophagy. 2007 Nov-Dec; 3(6):600-3. Yan P, Qing G, Qu Z, Wu CC, Rabson A, Xiao G. PMID: 17671417.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    26. Hsp90 regulates processing of NF-kappa B2 p100 involving protection of NF-kappa B-inducing kinase (NIK) from autophagy-mediated degradation. Cell Res. 2007 Jun; 17(6):520-30. Qing G, Yan P, Qu Z, Liu H, Xiao G. PMID: 17563756.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    27. Autophagy and NF-kappaB: fight for fate. Cytokine Growth Factor Rev. 2007 Jun-Aug; 18(3-4):233-43. Xiao G. PMID: 17485237; PMCID: PMC2810660.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    28. Endoproteolytic processing of C-terminally truncated NF-kappaB2 precursors at kappaB-containing promoters. Proc Natl Acad Sci U S A. 2007 Mar 27; 104(13):5324-9. Qing G, Qu Z, Xiao G. PMID: 17363471; PMCID: PMC1838492.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    29. Hsp90 inhibition results in autophagy-mediated proteasome-independent degradation of IkappaB kinase (IKK). Cell Res. 2006 Nov; 16(11):895-901. Qing G, Yan P, Xiao G. PMID: 17088896.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    30. Alternative pathways of NF-kappaB activation: a double-edged sword in health and disease. Cytokine Growth Factor Rev. 2006 Aug; 17(4):281-93. Xiao G, Rabson AB, Young W, Qing G, Qu Z. PMID: 16793322.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansCells
    31. Stabilization of basally translated NF-kappaB-inducing kinase (NIK) protein functions as a molecular switch of processing of NF-kappaB2 p100. J Biol Chem. 2005 Dec 09; 280(49):40578-82. Qing G, Qu Z, Xiao G. PMID: 16223731.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    32. Essential role of IkappaB kinase alpha in the constitutive processing of NF-kappaB2 p100. J Biol Chem. 2005 Mar 18; 280(11):9765-8. Qing G, Xiao G. PMID: 15677466.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    33. Regulation of NF-kappa B2 p100 processing by its cis-acting domain. J Biol Chem. 2005 Jan 07; 280(1):18-27. Qing G, Qu Z, Xiao G. PMID: 15485830.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    34. Tax deregulation of NF-kappaB2 p100 processing involves both beta-TrCP-dependent and -independent mechanisms. J Biol Chem. 2004 Oct 22; 279(43):44563-72. Qu Z, Qing G, Rabson A, Xiao G. PMID: 15310758.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    35. Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylation. J Biol Chem. 2004 Jul 16; 279(29):30099-105. Xiao G, Fong A, Sun SC. PMID: 15140882.
      View in: PubMed   Mentions: 130     Fields:    Translation:HumansCells
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    NIH Funding Acknowledgment: Important - All publications resulting from the utilization of SC CTSI resources are required to credit the SC CTSI grant by including the NIH funding acknowledgment and must comply with the NIH Public Access Policy.

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