Carolina Abdala, PhD

Title(s)Professor of Research Otolaryngology-Head and Neck Surgery
SchoolKeck School of Medicine of USC
Phone+1 323 865 1281
vCardDownload vCard

    Collapse Overview 
    Collapse Overview
    Hearing Communication Neuroscience: http://web-app.usc.edu/web/hcn/profile.php?fid=115

    AbdaLab Website: http://www-hsc.usc.edu/~abdala/

    Human Cochlear Function: A Continuum of Maturation and Aging.
    This project studies changes in cochlear function throughout the human lifespan, defining the timeline for these age-related shifts and the mechanisms driving the changes. We use primarily otoacaoustic emissions, a noninvasive ear canal probe of cochlear mechanics to learn about the human peripheral system. We apply both distortion- (DPOAE) and reflection-source (stimulus frequency OAEs and the reflection-component of the DPOAE) emissions using custom-algorithms, innovative swept-tone methodology and advanced analysis schemes. We disentangle the origin of age-related effects by separating distortion product OAEs into their dual components, distortion and reflection; and studying how each component’s phase and amplitude is impacted throughout the human lifespan. In our lab it is important to study both apical and basal halves of the cochlea to yield a more comprehensive understanding of how the cochlea codes low and high-frequency sounds. The apex has been minimally studied in humans, and wholly unexplored during maturation. Yet, we have recently reported striking immaturities in DPOAE phase for low-frequency signals coded in the apex of neonates. Our exploration of human cochlear function from base to apex using multiple OAE sources establishes a normative framework, provides detailed information about newborn cochlear maturation, and probes how the elderly cochlea ages into senescence. These findings contribute to more comprehensive cochlear models and toward the development of more innovative probes of cochlear function for human application. This project is funded by the NIH-NIDCD.

    Exploiting Dual OAE Sources to Study the Normal and Impaired Human Cochlea.
    This project attempts to exploit the distinct information embedded in reflection- and distortion-source OAEs to create a more comprehensive and descriptive joint test of cochlear function. At present, OAEs are used in a categorical sense, simply to detect hearing loss. However, once hearing loss is detected, we wish to learn about the underlying deficit and etiology. The ample information provided by the two OAE types (i.e. linear reflection and nonlinear distortion) can offer distinct clues about different aspects of cochlear function. We wish to exploit this distinct information to describe (not just detect) sensorineural hearing loss (SNHL). At present, SNHL is a catch-all term, defined by degree of loss and audiometric configuration. However, two hearing losses with identical audiograms can produce varying perceptual difficulties and varied success with hearing aids. By recording a combined reflection and distortion OAE profile over broad level and frequency ranges, we may be able to learn more about the underlying deficits that comprise the broad and vague category of SNHL. When used in combination, the properties embodied by each OAE can be considered in one joint metric. We are currently developing and testing this joint OAE protocol by recording stimulus frequency OAEs and the distortion component of DPOAEs in ears with normal and impaired hearing. This project is conducted in collaboration with fellow USC faculty members, Drs. Radha Kalluri and Christopher Shera.

    Collapse Research 
    Collapse Research Activities and Funding
    Otoacoustic Emissions: Evoking the Future
    NIH/NIDCD R13DC016825Sep 19, 2017 - Aug 31, 2018
    Role: Co-Principal Investigator
    Human Cochlear Function: A Continuum of Maturation and Aging
    NIH/NIDCD R01DC003552Aug 1, 1998 - Jul 31, 2020
    Role: Principal Investigator
    NIH/NIDCD R29DC003552Aug 1, 1998 - Jul 31, 2003
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Maxim T, Shera CA, Charaziak KK, Abdala C. Effects of Forward- and Emitted-Pressure Calibrations on the Variability of Otoacoustic Emission Measurements Across Repeated Probe Fits. Ear Hear. 2019 Mar 14. PMID: 30882535.
      View in: PubMed
    2. Abdala C, Ortmann AJ, Shera CA. Reflection- and Distortion-Source Otoacoustic Emissions: Evidence for Increased Irregularity in the Human Cochlea During Aging. J Assoc Res Otolaryngol. 2018 Oct; 19(5):493-510. PMID: 29968098.
      View in: PubMed
    3. Christensen AT, Abdala C, Shera CA. Probing Apical-Basal Differences in the Human Cochlea Using Distortion-Product Otoacoustic Emission Phase. AIP Conf Proc. 2018 May 31; 1965(1). PMID: 30089933.
      View in: PubMed
    4. Abdala C, Guardia YC, Shera CA. Swept-tone stimulus-frequency otoacoustic emissions: Normative data and methodological considerations. J Acoust Soc Am. 2018 Jan; 143(1):181. PMID: 29390734.
      View in: PubMed
    5. Salehi P, Ge MX, Gundimeda U, Michelle Baum L, Lael Cantu H, Lavinsky J, Tao L, Myint A, Cruz C, Wang J, Nikolakopoulou AM, Abdala C, Kelley MW, Ohyama T, Coate TM, Friedman RA. Role of Neuropilin-1/Semaphorin-3A signaling in the functional and morphological integrity of the cochlea. PLoS Genet. 2017 Oct; 13(10):e1007048. PMID: 29059194.
      View in: PubMed
    6. Abdala C, Kalluri R. Towards a joint reflection-distortion otoacoustic emission profile: Results in normal and impaired ears. J Acoust Soc Am. 2017 Aug; 142(2):812. PMID: 28863614.
      View in: PubMed
    7. Abdala C, Luo P, Shera CA. Characterizing spontaneous otoacoustic emissions across the human lifespan. J Acoust Soc Am. 2017 Mar; 141(3):1874. PMID: 28372113.
      View in: PubMed
    8. Ortmann AJ, Abdala C. Changes in the Compressive Nonlinearity of the Cochlea During Early Aging: Estimates From Distortion OAE Input/Output Functions. Ear Hear. 2016 Sep-Oct; 37(5):603-14. PMID: 27232070; PMCID: PMC4996700 [Available on 09/01/17].
    9. Shera CA, Abdala C. Frequency shifts in distortion-product otoacoustic emissions evoked by swept tones. J Acoust Soc Am. 2016 08; 140(2):936. PMID: 27586726.
      View in: PubMed
    10. Abdala C, Luo P, Shera CA. Optimizing swept-tone protocols for recording distortion-product otoacoustic emissions in adults and newborns. J Acoust Soc Am. 2015 Dec; 138(6):3785-99. PMID: 26723333; PMCID: PMC4691260 [Available on 12/01/16].
    11. Mishra SK, Abdala C. Stability of the medial olivocochlear reflex as measured by distortion product otoacoustic emissions. J Speech Lang Hear Res. 2015 Feb; 58(1):122-34. PMID: 25320951.
      View in: PubMed
    12. Kalluri R, Abdala C. Stimulus-frequency otoacoustic emissions in human newborns. J Acoust Soc Am. 2015 Jan; 137(1):EL78-84. PMID: 25618103; PMCID: PMC4272386.
    13. Abdala C, Kalluri R. Exploiting Dual Otoacoustic Emission Sources. AIP Conf Proc. 2015; 1703. PMID: 27695142.
      View in: PubMed
    14. Abdala C, Guérit F, Luo P, Shera CA. Distortion-product otoacoustic emission reflection-component delays and cochlear tuning: estimates from across the human lifespan. J Acoust Soc Am. 2014 Apr; 135(4):1950-8. PMID: 25234993; PMCID: PMC4167749.
    15. Abdala C, Dhar S, Ahmadi M, Luo P. Aging of the medial olivocochlear reflex and associations with speech perception. J Acoust Soc Am. 2014 Feb; 135(2):754-65. PMID: 25234884; PMCID: PMC3985974.
    16. Abdala C, Mishra S, Garinis A. Maturation of the human medial efferent reflex revisited. J Acoust Soc Am. 2013 Feb; 133(2):938-50. PMID: 23363111; PMCID: PMC3574130.
    17. Abdala C, Dhar S. Maturation and aging of the human cochlea: a view through the DPOAE looking glass. J Assoc Res Otolaryngol. 2012 Jun; 13(3):403-21. PMID: 22476702; PMCID: PMC3346898.
    18. Abdala C, Dhar S, Kalluri R. Deviations from Scaling Symmetry in the Apical Half of the Human Cochlea. AIP Conf Proc. 2011; 1403:483-488. PMID: 22745514.
      View in: PubMed
    19. Garinis A, Werner L, Abdala C. The relationship between MOC reflex and masked threshold. Hear Res. 2011 Dec; 282(1-2):128-37. PMID: 21878379; PMCID: PMC3242450.
    20. Abdala C, Dhar S, Mishra S. The breaking of cochlear scaling symmetry in human newborns and adults. J Acoust Soc Am. 2011 May; 129(5):3104-14. PMID: 21568413; PMCID: PMC3108391.
    21. Dhar S, Rogers A, Abdala C. Breaking away: violation of distortion emission phase-frequency invariance at low frequencies. J Acoust Soc Am. 2011 May; 129(5):3115-22. PMID: 21568414; PMCID: PMC3108392.
    22. Abdala C, Dhar S, Kalluri R. Level dependence of distortion product otoacoustic emission phase is attributed to component mixing. J Acoust Soc Am. 2011 May; 129(5):3123-33. PMID: 21568415; PMCID: PMC3108393.
    23. Keefe DH, Abdala C. Distortion-product otoacoustic-emission suppression tuning in human infants and adults using absorbed sound power. J Acoust Soc Am. 2011 Apr; 129(4):EL108-13. PMID: 21476616; PMCID: PMC3078155.
    24. Abdala C, Dhar S. Differences in distortion product otoacoustic emission phase recorded from human neonates using two popular probes. J Acoust Soc Am. 2010 Jul; 128(1):EL49-55. PMID: 20649189; PMCID: PMC2905449.
    25. Abdala C, Dhar S. Distortion product otoacoustic emission phase and component analysis in human newborns. J Acoust Soc Am. 2010 Jan; 127(1):316-25. PMID: 20058979; PMCID: PMC2821166.
    26. Abdala C, Mishra SK, Williams TL. Considering distortion product otoacoustic emission fine structure in measurements of the medial olivocochlear reflex. J Acoust Soc Am. 2009 Mar; 125(3):1584-94. PMID: 19275316; PMCID: PMC2736726.
    27. Abdala C, Oba SI, Ramanathan R. Changes in the DP-gram during the preterm and early postnatal period. Ear Hear. 2008 Aug; 29(4):512-23. PMID: 18349704; PMCID: PMC2694219.
    28. Dhar S, Abdala C. A comparative study of distortion-product-otoacoustic-emission fine structure in human newborns and adults with normal hearing. J Acoust Soc Am. 2007 Oct; 122(4):2191-202. PMID: 17902855.
      View in: PubMed
    29. Abdala C, Keefe DH, Oba SI. Distortion product otoacoustic emission suppression tuning and acoustic admittance in human infants: birth through 6 months. J Acoust Soc Am. 2007 Jun; 121(6):3617-27. PMID: 17552713; PMCID: PMC2667929.
    30. Keefe DH, Abdala C. Theory of forward and reverse middle-ear transmission applied to otoacoustic emissions in infant and adult ears. J Acoust Soc Am. 2007 Feb; 121(2):978-93. PMID: 17348521; PMCID: PMC2440519.
    31. Abdala C, Keefe DH. Effects of middle-ear immaturity on distortion product otoacoustic emission suppression tuning in infant ears. J Acoust Soc Am. 2006 Dec; 120(6):3832-42. PMID: 17225410.
      View in: PubMed
    32. Abdala C. Effects of aspirin on distortion product otoacoustic emission suppression in human adults: a comparison with neonatal data. J Acoust Soc Am. 2005 Sep; 118(3 Pt 1):1566-75. PMID: 16240817.
      View in: PubMed
    33. Abdala C. Distortion product otoacoustic emission (2f1-f2) suppression in 3-month-old infants: evidence for postnatal maturation of human cochlear function? J Acoust Soc Am. 2004 Dec; 116(6):3572-80. PMID: 15658708.
      View in: PubMed
    34. Abdala C. A longitudinal study of distortion product otoacoustic emission ipsilateral suppression and input/output characteristics in human neonates. J Acoust Soc Am. 2003 Dec; 114(6 Pt 1):3239-50. PMID: 14714805.
      View in: PubMed
    35. Abdala C, Fitzgerald TS. Ipsilateral distortion product otoacoustic emission (2f1-f2) suppression in children with sensorineural hearing loss. J Acoust Soc Am. 2003 Aug; 114(2):919-31. PMID: 12942973.
      View in: PubMed
    36. Chen P, Zindy F, Abdala C, Liu F, Li X, Roussel MF, Segil N. Progressive hearing loss in mice lacking the cyclin-dependent kinase inhibitor Ink4d. Nat Cell Biol. 2003 May; 5(5):422-6. PMID: 12717441.
      View in: PubMed
    37. Danhauer JL, Sahley TL, Abdala C. Statistical models for predicting Edgerton-Danhauer NST scores from pure-tone thresholds. J Aud Res. 1986 Jul; 26(3):167-75. PMID: 3680145.
      View in: PubMed
    38. Danhauer JL, Lucks LE, Abdala C. A survey of speech and other auditory perception assessment materials used by cochlear implant centers. J Aud Res. 1986 Apr; 26(2):75-87. PMID: 3624196.
      View in: PubMed