Mohamed Abou-el-Enein

Title(s)Associate Professor of Medicine (Clinical Scholar), Pediatrics, and Stem Cell Biology & Regenerative Medicine
SchoolKeck School of Medicine of Usc
Address1450 Biggy Street
Health Sciences Campus
Los Angeles CA 90033
ORCID ORCID Icon0000-0003-2903-9040 Additional info
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    Other Positions
    Title(s)Executive Director, Joint USC/CHLA Cell Therapy Program


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Discovery of Pyrano[2,3-c]pyrazole Derivatives as Novel Potential Human Coronavirus Inhibitors: Design, Synthesis, In Silico, In Vitro, and ADME Studies. Pharmaceuticals (Basel). 2024 Feb 02; 17(2). Allayeh AK, El-Boghdady AH, Said MA, Saleh MGA, Abdel-Aal MT, Abouelenein MG. PMID: 38399412.
      View in: PubMed   Mentions:
    2. Synthesis, molecular modeling Insights, and anticancer assessment of novel polyfunctionalized Pyridine congeners. Bioorg Chem. 2023 12; 141:106910. Abouelenein MG, El-Rashedy AA, Awad HM, El Farargy AF, Nassar IF, Nassrallah A. PMID: 37871393.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    3. Preparing for CAR T cell therapy: patient selection, bridging therapies and lymphodepletion. Nat Rev Clin Oncol. 2022 05; 19(5):342-355. Amini L, Silbert SK, Maude SL, Nastoupil LJ, Ramos CA, Brentjens RJ, Sauter CS, Shah NN, Abou-El-Enein M. PMID: 35318469.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    4. Adoptive transfer of ex vivo expanded regulatory T cells improves immune cell engraftment and therapy-refractory chronic GvHD. Mol Ther. 2022 06 01; 30(6):2298-2314. Landwehr-Kenzel S, Müller-Jensen L, Kuehl JS, Abou-El-Enein M, Hoffmann H, Muench S, Kaiser D, Roemhild A, von Bernuth H, Voeller M, Schmueck-Henneresse M, Gruhn B, Stervbo U, Babel N, Volk HD, Reinke P. PMID: 35240319; PMCID: PMC9171381.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    5. Scalable Manufacturing of CAR T cells for Cancer Immunotherapy. Blood Cancer Discov. 2021 Sep; 2(5):408-422. Abou-El-Enein M, Elsallab M, Feldman SA, Fesnak AD, Heslop HE, Marks P, Till BG, Bauer G, Savoldo B. PMID: 34568831; PMCID: PMC8462122.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    6. Evidence generation and reproducibility in cell and gene therapy research: A call to action. Mol Ther Methods Clin Dev. 2021 Sep 10; 22:11-14. Abou-El-Enein M, Angelis A, Appelbaum FR, Andrews NC, Bates SE, Bierman AS, Brenner MK, Cavazzana M, Caligiuri MA, Clevers H, Cooke E, Daley GQ, Dzau VJ, Ellis LM, Fineberg HV, Goldstein LSB, Gottschalk S, Hamburg MA, Ingber DE, Kohn DB, Krainer AR, Maus MV, Marks P, Mummery CL, Pettigrew RI, Rutter JL, Teichmann SA, Terzic A, Urnov FD, Williams DA, Wolchok JD, Lawler M, Turtle CJ, Bauer G, Ioannidis JPA. PMID: 34377737; PMCID: PMC8322039.
      View in: PubMed   Mentions: 5  
    7. Unproven stem cell interventions: A global public health problem requiring global deliberation. Stem Cell Reports. 2021 06 08; 16(6):1435-1445. Master Z, Matthews KRW, Abou-El-Enein M. PMID: 34107243; PMCID: PMC8190665.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansPHPublic Health
    8. Detection of SARS-CoV-2-specific memory B cells to delineate long-term COVID-19 immunity. Allergy. 2021 08; 76(8):2595-2599. Thieme CJ, Abou-El-Enein M, Fritsche E, Anft M, Paniskaki K, Skrzypczyk S, Doevelaar A, Elsallab M, Brindle N, Blazquez-Navarro A, Seibert FS, Meister TL, Pfaender S, Steinmann E, Witzke O, Westhoff TH, Stervbo U, Heine G, Roch T, Babel N. PMID: 33764510; PMCID: PMC8251309.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    9. Immunogenicity of CAR T cells in cancer therapy. Nat Rev Clin Oncol. 2021 06; 18(6):379-393. Wagner DL, Fritsche E, Pulsipher MA, Ahmed N, Hamieh M, Hegde M, Ruella M, Savoldo B, Shah NN, Turtle CJ, Wayne AS, Abou-El-Enein M. PMID: 33633361; PMCID: PMC8923136.
      View in: PubMed   Mentions: 94     Fields:    Translation:Humans
    10. Regulatory T cells for minimising immune suppression in kidney transplantation: phase I/IIa clinical trial. BMJ. 2020 10 21; 371:m3734. Roemhild A, Otto NM, Moll G, Abou-El-Enein M, Kaiser D, Bold G, Schachtner T, Choi M, Oellinger R, Landwehr-Kenzel S, Juerchott K, Sawitzki B, Giesler C, Sefrin A, Beier C, Wagner DL, Schlickeiser S, Streitz M, Schmueck-Henneresse M, Amini L, Stervbo U, Babel N, Volk HD, Reinke P. PMID: 33087345; PMCID: PMC7576328.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCellsCTClinical Trials
    11. COVID-19-Induced ARDS Is Associated with Decreased Frequency of Activated Memory/Effector T Cells Expressing CD11a+. Mol Ther. 2020 12 02; 28(12):2691-2702. Anft M, Paniskaki K, Blazquez-Navarro A, Doevelaar A, Seibert FS, Hölzer B, Skrzypczyk S, Kohut E, Kurek J, Zapka J, Wehler P, Kaliszczyk S, Bajda S, Thieme CJ, Roch T, Konik MJ, Berger MM, Brenner T, Kölsch U, Meister TL, Pfaender S, Steinmann E, Tempfer C, Watzl C, Dolff S, Dittmer U, Abou-El-Enein M, Westhoff TH, Witzke O, Stervbo U, Babel N. PMID: 33186542; PMCID: PMC7543694.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCellsPHPublic Health
    12. Senolytic CAR T Cells in Solid Tumors and Age-Related Pathologies. Mol Ther. 2020 10 07; 28(10):2108-2110. Feucht J, Abou-El-Enein M. PMID: 32841587; PMCID: PMC7545000.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    13. Mitigating Deficiencies in Evidence during Regulatory Assessments of Advanced Therapies: A Comparative Study with Other Biologicals. Mol Ther Methods Clin Dev. 2020 Sep 11; 18:269-279. Elsallab M, Bravery CA, Kurtz A, Abou-El-Enein M. PMID: 32637456; PMCID: PMC7327881.
      View in: PubMed   Mentions: 16  
    14. CAR T-cell product performance in haematological malignancies before and after marketing authorisation. Lancet Oncol. 2020 02; 21(2):e104-e116. Elsallab M, Levine BL, Wayne AS, Abou-El-Enein M. PMID: 32007196; PMCID: PMC7841982.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    15. Toward an Optimized Process for Clinical Manufacturing of CAR-Treg Cell Therapy. Trends Biotechnol. 2020 10; 38(10):1099-1112. Fritsche E, Volk HD, Reinke P, Abou-El-Enein M. PMID: 31982150.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    16. Cell and Gene Therapy Trials: Are We Facing an 'Evidence Crisis'? EClinicalMedicine. 2019 Jan; 7:13-14. Abou-El-Enein M, Hey SP. PMID: 31193634; PMCID: PMC6537560.
      View in: PubMed   Mentions: 12  
    17. Linking Scattered Stem Cell-Based Data to Advance Therapeutic Development. Trends Mol Med. 2019 01; 25(1):8-19. Kurtz A, Elsallab M, Sanzenbacher R, Abou-El-Enein M. PMID: 30497944.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    18. Telbivudine in chronic lymphocytic myocarditis and human parvovirus B19 transcriptional activity. ESC Heart Fail. 2018 10; 5(5):818-829. Van Linthout S, Elsanhoury A, Klein O, Sosnowski M, Miteva K, Lassner D, Abou-El-Enein M, Pieske B, Kühl U, Tschöpe C. PMID: 30099854; PMCID: PMC6165949.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    19. Concise Review: A Comprehensive Analysis of Reported Adverse Events in Patients Receiving Unproven Stem Cell-Based Interventions. Stem Cells Transl Med. 2018 09; 7(9):676-685. Bauer G, Elsallab M, Abou-El-Enein M. PMID: 30063299; PMCID: PMC6127222.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    20. The Human Genome Editing Race: Loosening Regulatory Standards for Commercial Advantage? Trends Biotechnol. 2019 02; 37(2):120-123. Cathomen T, Schüle S, Schüßler-Lenz M, Abou-El-Enein M. PMID: 30017092.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    21. Registry Contributions to Strengthen Cell and Gene Therapeutic Evidence. Mol Ther. 2018 05 02; 26(5):1172-1176. Abou-El-Enein M, Grainger DW, Kili S. PMID: 29685384; PMCID: PMC5993957.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    22. Enhancing patient-level clinical data access to promote evidence-based practice and incentivize therapeutic innovation. Adv Drug Deliv Rev. 2018 Nov - Dec; 136-137:97-104. Fortunato A, Grainger DW, Abou-El-Enein M. PMID: 29408180.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    23. Human Genome Editing in the Clinic: New Challenges in Regulatory Benefit-Risk Assessment. Cell Stem Cell. 2017 10 05; 21(4):427-430. Abou-El-Enein M, Cathomen T, Ivics Z, June CH, Renner M, Schneider CK, Bauer G. PMID: 28985524.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    24. Accelerating Patients' Access to Advanced Therapies in the EU. Mol Ther Methods Clin Dev. 2017 Dec 15; 7:15-19. Elsanhoury A, Sanzenbacher R, Reinke P, Abou-El-Enein M. PMID: 28971109; PMCID: PMC5609878.
      View in: PubMed   Mentions: 8  
    25. The path to successful commercialization of cell and gene therapies: empowering patient advocates. Cytotherapy. 2017 02; 19(2):293-298. Bauer G, Abou-El-Enein M, Kent A, Poole B, Forte M. PMID: 27956199.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    26. Clinical Development of Cell Therapies: Setting the Stage for Academic Success. Clin Pharmacol Ther. 2017 Jan; 101(1):35-38. Abou-El-Enein M, Volk HD, Reinke P. PMID: 27709611.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    27. Overcoming Challenges Facing Advanced Therapies in the EU Market. Cell Stem Cell. 2016 09 01; 19(3):293-7. Abou-El-Enein M, Elsanhoury A, Reinke P. PMID: 27588746.
      View in: PubMed   Mentions: 58     Fields:    Translation:Humans
    28. Strategies for Derisking Translational Processes for Biomedical Technologies. Trends Biotechnol. 2017 02; 35(2):100-108. Abou-El-Enein M, Duda GN, Gruskin EA, Grainger DW. PMID: 27499276.
      View in: PubMed   Mentions: 10     Fields:    Translation:PHPublic Health
    29. Putting a price tag on novel autologous cellular therapies. Cytotherapy. 2016 08; 18(8):1056-1061. Abou-El-Enein M, Bauer G, Medcalf N, Volk HD, Reinke P. PMID: 27288308.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    30. Deciphering the EU clinical trials regulation. Nat Biotechnol. 2016 Mar; 34(3):231-3. Abou-El-Enein M, Schneider CK. PMID: 26963541.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    31. Gene therapy: a possible future standard for HIV care. Trends Biotechnol. 2015 Jul; 33(7):374-6. Abou-El-Enein M, Bauer G, Reinke P. PMID: 26088914.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    32. The business case for cell and gene therapies. Nat Biotechnol. 2014 Dec; 32(12):1192-3. Abou-El-Enein M, Bauer G, Reinke P. PMID: 25489833.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    33. A roadmap toward clinical translation of genetically-modified stem cells for treatment of HIV. Trends Mol Med. 2014 Nov; 20(11):632-42. Abou-El-Enein M, Bauer G, Reinke P, Renner M, Schneider CK. PMID: 25262540.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    34. Good Manufacturing Practices (GMP) manufacturing of advanced therapy medicinal products: a novel tailored model for optimizing performance and estimating costs. Cytotherapy. 2013 Mar; 15(3):362-83. Abou-El-Enein M, Römhild A, Kaiser D, Beier C, Bauer G, Volk HD, Reinke P. PMID: 23579061.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
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