Michael J Heffernan

Title(s)Associate Professor of Clinical Orthopaedics Surgery
SchoolKeck School of Medicine of Usc
Address4640 West Sunset Blvd
Off Campus
Los Angeles CA 90027
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    1. Transforming Your Operating Room into a High Functioning Team: A Survival Guide for Junior Attendings in the OR. J Pediatr Orthop. 2022 May-Jun 01; 42(Suppl 1):S25-S28. Heffernan MJ, Andras LM. PMID: 35405697.
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    2. The Effect of Surgeon Experience on Outcomes Following Growth Friendly Instrumentation for Early Onset Scoliosis. J Pediatr Orthop. 2022 Feb 01; 42(2):e132-e137. Heffernan MJ, Younis M, Glotzbecker MP, Garg S, Leonardi C, Poon SC, Brooks JT, Sturm PF, Sponseller PD, Vitale MG, Emans JB, Roye BD, Pediatric Spine Study Group (PSSG). PMID: 34759190.
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    3. The Feasibility of Utilizing Malunion Criteria to Limit Radiographs After Spica Casting for Pediatric Femur Fractures. J Pediatr Orthop. 2022 Feb 01; 42(2):e115-e119. Barnett SA, Song BM, Yan J, Lucak TJ, Leonardi C, Kadhim M, Heffernan MJ. PMID: 34995257.
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    4. Surgical Outcomes of Obese Patients With Adolescent Idiopathic Scoliosis From Endemic Areas of Obesity in the United States. J Pediatr Orthop. 2021 Nov-Dec 01; 41(10):e865-e870. McDonald TC, Heffernan MJ, Ramo B, Haber L, Sheffer B, Murphy J, Murphy R, Fletcher N, Coyne K, Lubicky J, Bumpass DB, Crawford C, Carreon L, Toner S, Stafford WH, Poppino K, Adams T, Song BM, Gidwani S, Taillac H, Cornaghie M, Sukkarieh H, Wright PB, Conklin M, Gilbert S, Thimothee J, Bhanat E, Brooks JT, Pediatric Orthopaedic Obesity Research Consortium. PMID: 34469396.
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    5. Pediatric Distal Third Tibial Shaft Fractures: Are Short Leg Casts a Reasonable Option? J Pediatr Orthop. 2021 Nov-Dec 01; 41(10):e936. Barnett SA, Heffernan MJ. PMID: 34325443.
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    6. The Impact of Cast Immobilization on Return to Daycare. J Pediatr Orthop. 2021 Oct 01; 41(9):571-575. Heffernan MJ, Barnett SA, Nungesser ME, Song BM, Leonardi C, Gonzales J. PMID: 34334695.
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    7. Atypical osteochondroma of the lumbar spine associated with suprasellar pineal germinoma: A case report. World J Orthop. 2021 Sep 18; 12(9):720-726. Suwak P, Barnett SA, Song BM, Heffernan MJ. PMID: 34631455; PMCID: PMC8472447.
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    8. Phenomenological Constraints on the Transport Properties of QCD Matter with Data-Driven Model Averaging. Phys Rev Lett. 2021 Jun 18; 126(24):242301. Everett D, Ke W, Paquet JF, Vujanovic G, Bass SA, Du L, Gale C, Heffernan M, Heinz U, Liyanage D, Luzum M, Majumder A, McNelis M, Shen C, Xu Y, Angerami A, Cao S, Chen Y, Coleman J, Cunqueiro L, Dai T, Ehlers R, Elfner H, Fan W, Fries RJ, Garza F, He Y, Jacak BV, Jacobs PM, Jeon S, Kim B, Kordell M, Kumar A, Mak S, Mulligan J, Nattrass C, Oliinychenko D, Park C, Putschke JH, Roland G, Schenke B, Schwiebert L, Silva A, Sirimanna C, Soltz RA, Tachibana Y, Wang XN, Wolpert RL, JETSCAPE Collaboration. PMID: 34213947.
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    9. Intraoperative Burden of Flexible Intramedullary Nailing and Spica Casting for Femur Fractures in Young Children. J Pediatr Orthop. 2021 May 13. Barnett SA, Song BM, Yan J, Leonardi C, Gonzales JA, Heffernan MJ. PMID: 33999567.
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    10. Single-level fusion without decompression for high-grade spondylolithesis in adolescents: a novel surgical strategy. Spine Deform. 2021 09; 9(5):1457-1464. Alijanipour P, Heffernan MJ, King AGS. PMID: 33886114.
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    11. Microdose protocol stereoradiography has similar reliability to standard low-dose protocol during concurrent Sanders skeletal maturity staging. Spine Deform. 2021 09; 9(5):1333-1339. Nguyen CV, Luong M, Heffernan MJ, Poon SC, Badkoobehi H, Shah SA, Cho RH. PMID: 33725327.
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    12. Assessing the Impact of the Pediatric Orthopaedic Society of North America (POSNA) Visiting Scholar Program. J Pediatr Orthop. 2021 Mar 01; 41(3):197-201. Heffernan MJ, Song B, Bovid KM, Leonardi C, Fornari ED. PMID: 33534369.
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    13. Comparison of Short-leg and Long-leg Casts for the Treatment of Distal Third Tibial Shaft Fractures in Children. J Pediatr Orthop. 2021 Mar 01; 41(3):e259-e265. Barnett SA, Fontenot B, Leonardi C, Gonzales JA, Gargiulo D, Heffernan MJ. PMID: 33417388.
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    14. Advancing pediatric medical device development via non-dilutive NIH SBIR/STTR grant funding. J Pediatr Surg. 2021 Nov; 56(11):2118-2123. Sun RC, Kamat I, Byju AG, Wettergreen M, Heffernan MJ, Willson R, Haridas B, Koh CJ. PMID: 33558071; PMCID: PMC9125501.
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    15. Bisphosphonates and parathyroid hormone analogs for improving bone quality in spinal fusion: State of evidence. Orthop Rev (Pavia). 2020 Aug 06; 12(2):8590. Atesok K, Stippler M, Striano BM, Xiong G, Lindsey M, Cappellucci E, Psilos A, Richter S, Heffernan MJ, Theiss S, Papavassiliou E. PMID: 32922704; PMCID: PMC7461648.
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    16. Enhanced Recovery After Pediatric Scoliosis Surgery: Key Components and Current Practice. Orthopedics. 2020 Sep 01; 43(5):e338-e344. Song BM, Kadhim M, Shanmugam JP, King AG, Heffernan MJ. PMID: 32745223.
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    17. Predictors of Open Reduction in Pediatric Femur Fractures Treated With Flexible Nails. J Pediatr Orthop. 2020 Aug; 40(7):e566-e571. Heffernan MJ, Shelton W, Song B, Lucak TJ, Leonardi C, Kadhim M. PMID: 31972726.
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    18. Quantifying the forces needed for ureteral stent removal: Initial evaluation of magnetic stent removal devices on benchtop and porcine models. J Pediatr Urol. 2020 Oct; 16(5):596.e1-596.e8. Sheth KR, White JT, Puttmann K, Waters D, Soto M, Bell M, Aboufadel T, Heffernan MJ, Richardson E, Song SH, Koh CJ. PMID: 32340884.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    19. The Reverse Oblique Supracondylar Humerus Fracture: Description of a Novel Fracture Pattern. J Pediatr Orthop. 2020 Feb; 40(2):e131-e137. Heffernan MJ, Lucak T, Igbokwe L, Yan J, Gargiulo D, Khadim M. PMID: 31022014.
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    20. Fate of Hardware in Spinal Infections. Surg Infect (Larchmt). 2020 Jun; 21(5):404-410. Atesok K, Vaccaro A, Stippler M, Striano BM, Carr M, Heffernan M, Theiss S, Papavassiliou E. PMID: 31855116.
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    21. Current status of scoliosis school screening: targeted screening of underserved populations may be the solution. Public Health. 2020 Jan; 178:72-77. Kadhim M, Lucak T, Schexnayder S, King A, Terhoeve C, Song B, Heffernan MJ. PMID: 31627054.
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    22. Current Trends in Pediatric Spine Deformity Surgery: Multimodal Pain Management and Rapid Recovery. Global Spine J. 2020 May; 10(3):346-352. Shah SA, Guidry R, Kumar A, White T, King A, Heffernan MJ. PMID: 32313800; PMCID: PMC7160808.
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    23. Advancing Simulation-Based Orthopaedic Surgical Skills Training: An Analysis of the Challenges to Implementation. Adv Orthop. 2019; 2019:2586034. Atesok K, Hurwitz S, Anderson DD, Satava R, Thomas GW, Tufescu T, Heffernan MJ, Papavassiliou E, Theiss S, Marsh JL. PMID: 31565441; PMCID: PMC6745149.
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    24. Dimensions of the paediatric femur: anatomical limitations of flexible intramedullary nailing. J Child Orthop. 2019 Apr 01; 13(2):220-225. Lucak T, Raju S, Andrews A, Igbokwe L, Heffernan MJ. PMID: 30996748; PMCID: PMC6442501.
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    25. Improving Complex Pediatric and Adult Spine Care While Embracing the Value Equation. Spine Deform. 2019 03; 7(2):228-235. Sethi RK, Yanamadala V, Shah SA, Fletcher ND, Flynn J, Lafage V, Schwab F, Heffernan M, DeKleuver M, Mcleod L, Leveque JC, Vitale M. PMID: 30660216.
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    26. Current Strategies in Prevention of Postoperative Infections in Spine Surgery. Global Spine J. 2020 Apr; 10(2):183-194. Atesok K, Papavassiliou E, Heffernan MJ, Tunmire D, Sitnikov I, Tanaka N, Rajaram S, Pittman J, Gokaslan ZL, Vaccaro A, Theiss S. PMID: 32206518; PMCID: PMC7076595.
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    27. Early Career Reflections: Observations From the First 5 Years in Practice. Orthopedics. 2018 09 01; 41(5):254-255. Heffernan MJ. PMID: 30231183.
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    28. Risk factors for nonunion of bone fracture in pediatric patients: An inception cohort study of 237,033 fractures. Medicine (Baltimore). 2018 Aug; 97(31):e11691. Zura R, Kaste SC, Heffernan MJ, Accousti WK, Gargiulo D, Wang Z, Steen RG. PMID: 30075567; PMCID: PMC6081185.
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    29. 3M-052 as an adjuvant for a PLGA microparticle-based Leishmania donovani recombinant protein vaccine. J Biomed Mater Res B Appl Biomater. 2018 05; 106(4):1587-1594. Wang Q, Barry MA, Seid CA, Hudspeth EM, McAtee CP, Heffernan MJ. PMID: 28804955.
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    30. Fluoroscopic imaging overestimates the screw tip to subchondral bone distance in a cadaveric model of slipped capital femoral epiphysis. J Child Orthop. 2017; 11(1):36-41. Heffernan MJ, Snyder B, Zhou H, Li X. PMID: 28439307; PMCID: PMC5382334.
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    31. Management Protocol For Shaft Femur Fractures in Preschool Age Children: Do We Need to Rethink? J Pediatr Orthop. 2016 Jul-Aug; 36(5):e63. Arkader A, Heffernan MJ. PMID: 26296223.
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    32. Comments on Minimum of 2 Years Instead of Reporting Results at the Conclusion of Treatment (Hefferman et al, "Treatment of Femur Fractures in Young Children: A Multicenter Comparison of Flexible Intramedullary Nails to Spica Casting in Young Children Aged 2 to 6 Years." J Pediatr Orthop. 2015;35(2):126-129. J Pediatr Orthop. 2016 06; 36(4):e50. Heffernan MJ, Arkader A. PMID: 26296222.
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    33. Variability of the Anterior Humeral Line in Normal Pediatric Elbows. J Pediatr Orthop. 2016 Mar; 36(2):e14-6. Ryan DD, Lightdale-Miric NR, Joiner ER, Wren TA, Spragg L, Heffernan MJ, Kay RM, Skaggs DL. PMID: 26035494.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    34. A therapeutic nanoparticle vaccine against Trypanosoma cruzi in a BALB/c mouse model of Chagas disease. Hum Vaccin Immunother. 2016 04 02; 12(4):976-87. Barry MA, Wang Q, Jones KM, Heffernan MJ, Buhaya MH, Beaumier CM, Keegan BP, Zhan B, Dumonteil E, Bottazzi ME, Hotez PJ. PMID: 26890466; PMCID: PMC4962947.
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    35. Expression and purification of an engineered, yeast-expressed Leishmania donovani nucleoside hydrolase with immunogenic properties. Hum Vaccin Immunother. 2016 07 02; 12(7):1707-20. Hudspeth EM, Wang Q, Seid CA, Hammond M, Wei J, Liu Z, Zhan B, Pollet J, Heffernan MJ, McAtee CP, Engler DA, Matsunami RK, Strych U, Asojo OA, Hotez PJ, Bottazzi ME. PMID: 26839079; PMCID: PMC4964838.
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    36. Treatment of femur fractures in young children: a multicenter comparison of flexible intramedullary nails to spica casting in young children aged 2 to 6 years. J Pediatr Orthop. 2015 Mar; 35(2):126-9. Heffernan MJ, Gordon JE, Sabatini CS, Keeler KA, Lehmann CL, O'Donnell JC, Seehausen DA, Luhmann SJ, Arkader A. PMID: 25105984.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    37. Time course study of the antigen-specific immune response to a PLGA microparticle vaccine formulation. Biomaterials. 2014 Sep; 35(29):8385-93. Wang Q, Tan MT, Keegan BP, Barry MA, Heffernan MJ. PMID: 24986256.
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    38. Comparison of outcomes after posterior spinal fusion for adolescent idiopathic and neuromuscular scoliosis: does the surgical first assistant's level of training matter? Spine (Phila Pa 1976). 2014 Apr 15; 39(8):648-55. Heffernan MJ, Seehausen DA, Andras LM, Skaggs DL. PMID: 24480953.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    39. Innovation for the 'bottom 100 million': eliminating neglected tropical diseases in the Americas. Adv Exp Med Biol. 2013; 764:1-12. Hotez PJ, Dumonteil E, Heffernan MJ, Bottazzi ME. PMID: 23654053.
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    40. Accelerating the development of a therapeutic vaccine for human Chagas disease: rationale and prospects. Expert Rev Vaccines. 2012 Sep; 11(9):1043-55. Dumonteil E, Bottazzi ME, Zhan B, Heffernan MJ, Jones K, Valenzuela JG, Kamhawi S, Ortega J, de Leon Rosales SP, Lee BY, Bacon KM, Fleischer B, Slingsby BT, Cravioto MB, Tapia-Conyer R, Hotez PJ. PMID: 23151163; PMCID: PMC3819810.
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    41. Use of the F-Tool for the removal of a bent intramedullary femoral nail with a sagittal plane deformity. Orthopedics. 2012 Mar 07; 35(3):e438-41. Heffernan MJ, Leclair W, Li X. PMID: 22385460.
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    42. Chemoprevention of nonmelanoma skin cancer with celecoxib: a randomized, double-blind, placebo-controlled trial. J Natl Cancer Inst. 2010 Dec 15; 102(24):1835-44. Elmets CA, Viner JL, Pentland AP, Cantrell W, Lin HY, Bailey H, Kang S, Linden KG, Heffernan M, Duvic M, Richmond E, Elewski BE, Umar A, Bell W, Gordon GB. PMID: 21115882; PMCID: PMC3001966.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansCTClinical Trials
    43. Biomechanical effects of harvesting bone graft with the Reamer/Irrigator/Aspirator on the adult femur: a cadaver study. Injury. 2010 Nov; 41 Suppl 2:S85-9. Silva JA, McCormick JJ, Reed MA, Morse AS, Heffernan MJ, Lavado RD, Billiar K, Wixted JJ. PMID: 21144935.
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    44. In vivo efficacy of a chitosan/IL-12 adjuvant system for protein-based vaccines. Biomaterials. 2011 Jan; 32(3):926-32. Heffernan MJ, Zaharoff DA, Fallon JK, Schlom J, Greiner JW. PMID: 20965561; PMCID: PMC2992965.
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    45. Medial pelvic migration of the lag screw in a short gamma nail after hip fracture fixation: a case report and review of the literature. J Orthop Surg Res. 2010 Aug 27; 5:62. Li X, Heffernan MJ, Kane C, Leclair W. PMID: 20799945; PMCID: PMC2939628.
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    46. Upper extremity stress fractures and spondylolysis in an adolescent baseball pitcher with an associated endocrine abnormality: a case report. J Pediatr Orthop. 2010 Jun; 30(4):339-43. Li X, Heffernan MJ, Mortimer ES. PMID: 20502233.
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    47. Disulfide-crosslinked polyion micelles for delivery of protein therapeutics. Ann Biomed Eng. 2009 Oct; 37(10):1993-2002. Heffernan MJ, Murthy N. PMID: 19513846.
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    48. The stimulation of CD8+ T cells by dendritic cells pulsed with polyketal microparticles containing ion-paired protein antigen and poly(inosinic acid)-poly(cytidylic acid). Biomaterials. 2009 Feb; 30(5):910-8. Heffernan MJ, Kasturi SP, Yang SC, Pulendran B, Murthy N. PMID: 19036430; PMCID: PMC3736733.
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    49. Polyketal microparticles: a new delivery vehicle for superoxide dismutase. Bioconjug Chem. 2007 Jan-Feb; 18(1):4-7. Lee S, Yang SC, Heffernan MJ, Taylor WR, Murthy N. PMID: 17226951.
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    50. Off-label uses of biologics in dermatology: interferon and intravenous immunoglobulin (part 1 of 2). J Am Acad Dermatol. 2007 Jan; 56(1):e1-54. Smith DI, Swamy PM, Heffernan MP. PMID: 17190617.
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    51. Transfer for urgent percutaneous coronary intervention early after thrombolysis for ST-elevation myocardial infarction: the TRANSFER-AMI pilot feasibility study. Can J Cardiol. 2006 Nov; 22(13):1121-6. Cantor WJ, Burnstein J, Choi R, Heffernan M, Dzavik V, Lazzam C, Duic M, Fitchett D, Tan M, Wawrzyniak J, Kassam S, Dhingra S, Morrison LJ, Langer A, Goodman SG. PMID: 17102829; PMCID: PMC2569051.
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    52. Polyketal nanoparticles: a new pH-sensitive biodegradable drug delivery vehicle. Bioconjug Chem. 2005 Nov-Dec; 16(6):1340-2. Heffernan MJ, Murthy N. PMID: 16287226.
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    53. Myocardial recovery using ventricular assist devices: prevalence, clinical characteristics, and outcomes. Circulation. 2005 Aug 30; 112(9 Suppl):I32-6. Simon MA, Kormos RL, Murali S, Nair P, Heffernan M, Gorcsan J, Winowich S, McNamara DM. PMID: 16159839.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    54. Scleromyxoedema: treatment of cutaneous and systemic manifestations with high-dose intravenous immunoglobulin. Br J Dermatol. 2003 Dec; 149(6):1276-81. Kulczycki A, Nelson M, Eisen A, Heffernan M. PMID: 14674909.
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    55. A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis. Nat Genet. 2003 Dec; 35(4):349-56. Helms C, Cao L, Krueger JG, Wijsman EM, Chamian F, Gordon D, Heffernan M, Daw JA, Robarge J, Ott J, Kwok PY, Menter A, Bowcock AM. PMID: 14608357.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansCells
    56. Prognosis of endodontically treated teeth? Point. Quintessence Int. 2003 Jul-Aug; 34(7):558-60. Heffernan M, Martin W, Morton D. PMID: 12946076.
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    57. Relative translucency of six all-ceramic systems. Part II: core and veneer materials. J Prosthet Dent. 2002 Jul; 88(1):10-5. Heffernan MJ, Aquilino SA, Diaz-Arnold AM, Haselton DR, Stanford CM, Vargas MA. PMID: 12239473.
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    58. Relative translucency of six all-ceramic systems. Part I: core materials. J Prosthet Dent. 2002 Jul; 88(1):4-9. Heffernan MJ, Aquilino SA, Diaz-Arnold AM, Haselton DR, Stanford CM, Vargas MA. PMID: 12239472.
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    59. Pamidronate reduces skeletal morbidity in women with advanced breast cancer and lytic bone lesions: a randomized, placebo-controlled trial. Protocol 18 Aredia Breast Cancer Study Group. J Clin Oncol. 1999 Mar; 17(3):846-54. Theriault RL, Lipton A, Hortobagyi GN, Leff R, Glück S, Stewart JF, Costello S, Kennedy I, Simeone J, Seaman JJ, Knight RD, Mellars K, Heffernan M, Reitsma DJ. PMID: 10071275.
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    60. Long-term prevention of skeletal complications of metastatic breast cancer with pamidronate. Protocol 19 Aredia Breast Cancer Study Group. J Clin Oncol. 1998 Jun; 16(6):2038-44. Hortobagyi GN, Theriault RL, Lipton A, Porter L, Blayney D, Sinoff C, Wheeler H, Simeone JF, Seaman JJ, Knight RD, Heffernan M, Mellars K, Reitsma DJ. PMID: 9626201.
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