Joy Goldstein

Title(s)Volunteer Faculty
SchoolKeck School of Medicine of Usc
Address4640 West Sunset Blvd
Off Campus
Los Angeles CA 90027
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. CYP2C8 Is a Novel Target of Peroxisome Proliferator-Activated Receptor α in Human Liver. Mol Pharmacol. 2016 Jan; 89(1):154-64. Makia NL, Goldstein JA. PMID: 26467040; PMCID: PMC4702104.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    2. Epigenetic modification of histone 3 lysine 27: mediator subunit MED25 is required for the dissociation of polycomb repressive complex 2 from the promoter of cytochrome P450 2C9. J Biol Chem. 2015 Jan 23; 290(4):2264-78. Englert NA, Luo G, Goldstein JA, Surapureddi S. PMID: 25391650; PMCID: PMC4303677.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    3. The influence of the CYP2C19*10 allele on clopidogrel activation and CYP2C19*2 genotyping. Pharmacogenet Genomics. 2014 Aug; 24(8):381-6. Langaee TY, Zhu HJ, Wang X, El Rouby N, Markowitz JS, Goldstein JA, Johnson JA. PMID: 24945780; PMCID: PMC4090277.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    4. Med25 is required for estrogen receptor alpha (ERα)-mediated regulation of human CYP2C9 expression. Biochem Pharmacol. 2014 Aug 15; 90(4):425-31. Shi Z, Yang W, Goldstein JA, Zhang SY. PMID: 24960263; PMCID: PMC4292888.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    5. Regulation of human CYP2C9 expression by electrophilic stress involves activator protein 1 activation and DNA looping. Mol Pharmacol. 2014 Aug; 86(2):125-37. Makia NL, Surapureddi S, Monostory K, Prough RA, Goldstein JA. PMID: 24830941; PMCID: PMC4127925.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    6. RBCK1, an E3 ubiquitin ligase, interacts with and ubiquinates the human pregnane X receptor. Drug Metab Dispos. 2013 Feb; 41(2):398-405. Rana R, Coulter S, Kinyamu H, Goldstein JA. PMID: 23160820; PMCID: PMC3558864.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    7. Associations of ABCB1 and IL-10 genetic polymorphisms with sirolimus-induced dyslipidemia in renal transplant recipients. Transplantation. 2012 Nov 15; 94(9):971-7. Sam WJ, Chamberlain CE, Lee SJ, Goldstein JA, Hale DA, Mannon RB, Kirk AD, Hon YY. PMID: 23073467; PMCID: PMC3491093.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    8. Cyclophosphamide and 4-hydroxycyclophosphamide pharmacokinetics in patients with glomerulonephritis secondary to lupus and small vessel vasculitis. Br J Clin Pharmacol. 2012 Sep; 74(3):445-55. Joy MS, La M, Wang J, Bridges AS, Hu Y, Hogan SL, Frye RF, Blaisdell J, Goldstein JA, Dooley MA, Brouwer KL, Falk RJ. PMID: 22380717; PMCID: PMC3477346.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    9. Human CYP2C8 is post-transcriptionally regulated by microRNAs 103 and 107 in human liver. Mol Pharmacol. 2012 Sep; 82(3):529-40. Zhang SY, Surapureddi S, Coulter S, Ferguson SS, Goldstein JA. PMID: 22723340; PMCID: PMC3422698.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    10. Comparison of CYP3A4 and CYP3A5: the effects of cytochrome b5 and NADPH-cytochrome P450 reductase on testosterone hydroxylation activities. Drug Metab Pharmacokinet. 2012; 27(6):663-7. Lee SJ, Goldstein JA. PMID: 22785258; PMCID: PMC3602955.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    11. P2X7 receptor-NADPH oxidase axis mediates protein radical formation and Kupffer cell activation in carbon tetrachloride-mediated steatohepatitis in obese mice. Free Radic Biol Med. 2012 May 01; 52(9):1666-79. Chatterjee S, Rana R, Corbett J, Kadiiska MB, Goldstein J, Mason RP. PMID: 22343416; PMCID: PMC3341527.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    12. Associations of ABCB1 3435C>T and IL-10-1082G>A polymorphisms with long-term sirolimus dose requirements in renal transplant patients. Transplantation. 2011 Dec 27; 92(12):1342-7. Sam WJ, Chamberlain CE, Lee SJ, Goldstein JA, Hale DA, Mannon RB, Kirk AD, Hon YY. PMID: 22094953; PMCID: PMC3237821.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    13. Liganded pregnane X receptor represses the human sulfotransferase SULT1E1 promoter through disrupting its chromatin structure. Nucleic Acids Res. 2011 Oct; 39(19):8392-403. Kodama S, Hosseinpour F, Goldstein JA, Negishi M. PMID: 21764778; PMCID: PMC3201858.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    14. NCOA6 differentially regulates the expression of the CYP2C9 and CYP3A4 genes. Pharmacol Res. 2011 May; 63(5):405-13. Surapureddi S, Rana R, Goldstein JA. PMID: 21292004; PMCID: PMC3082001.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    15. Med25 is required for RNA polymerase II recruitment to specific promoters, thus regulating xenobiotic and lipid metabolism in human liver. Mol Cell Biol. 2011 Feb; 31(3):466-81. Rana R, Surapureddi S, Kam W, Ferguson S, Goldstein JA. PMID: 21135126; PMCID: PMC3028616.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    16. The nuclear receptors constitutive active/androstane receptor and pregnane x receptor activate the Cyp2c55 gene in mouse liver. Drug Metab Dispos. 2010 Jul; 38(7):1177-82. Konno Y, Kamino H, Moore R, Lih F, Tomer KB, Zeldin DC, Goldstein JA, Negishi M. PMID: 20371638; PMCID: PMC2908984.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    17. Hepatocyte nuclear factor 4{alpha} regulates rifampicin-mediated induction of CYP2C genes in primary cultures of human hepatocytes. Drug Metab Dispos. 2010 Apr; 38(4):591-9. Rana R, Chen Y, Ferguson SS, Kissling GE, Surapureddi S, Goldstein JA. PMID: 20086032; PMCID: PMC2845933.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    18. CYP2C9 genotype and pharmacodynamic responses to losartan in patients with primary and secondary kidney diseases. Eur J Clin Pharmacol. 2009 Sep; 65(9):947-53. Joy MS, Dornbrook-Lavender K, Blaisdell J, Hilliard T, Boyette T, Hu Y, Hogan SL, Candiani C, Falk RJ, Goldstein JA. PMID: 19669737; PMCID: PMC2901912.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    19. The transcriptional regulation of the human CYP2C genes. Curr Drug Metab. 2009 Jul; 10(6):567-78. Chen Y, Goldstein JA. PMID: 19702536; PMCID: PMC2808111.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    20. Kidney function influences warfarin responsiveness and hemorrhagic complications. J Am Soc Nephrol. 2009 Apr; 20(4):912-21. Limdi NA, Beasley TM, Baird MF, Goldstein JA, McGwin G, Arnett DK, Acton RT, Allon M. PMID: 19225037; PMCID: PMC2663833.
      View in: PubMed   Mentions: 86     Fields:    Translation:Humans
    21. Identification of human CYP2C8 as a retinoid-related orphan nuclear receptor target gene. J Pharmacol Exp Ther. 2009 Apr; 329(1):192-201. Chen Y, Coulter S, Jetten AM, Goldstein JA. PMID: 19164466; PMCID: PMC2670598.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    22. VKORC1 polymorphisms, haplotypes and haplotype groups on warfarin dose among African-Americans and European-Americans. Pharmacogenomics. 2008 Oct; 9(10):1445-58. Limdi NA, Beasley TM, Crowley MR, Goldstein JA, Rieder MJ, Flockhart DA, Arnett DK, Acton RT, Liu N. PMID: 18855533; PMCID: PMC2586955.
      View in: PubMed   Mentions: 62     Fields:    Translation:Humans
    23. Nuclear receptor coactivator 6 mediates the synergistic activation of human cytochrome P-450 2C9 by the constitutive androstane receptor and hepatic nuclear factor-4alpha. Mol Pharmacol. 2008 Sep; 74(3):913-23. Surapureddi S, Rana R, Reddy JK, Goldstein JA. PMID: 18552123; PMCID: PMC3815599.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    24. Influence of CYP2C9 and VKORC1 on warfarin dose, anticoagulation attainment and maintenance among European-Americans and African-Americans. Pharmacogenomics. 2008 May; 9(5):511-26. Limdi NA, Arnett DK, Goldstein JA, Beasley TM, McGwin G, Adler BK, Acton RT. PMID: 18466099; PMCID: PMC2757655.
      View in: PubMed   Mentions: 75     Fields:    Translation:Humans
    25. Midazolam metabolism in cytochrome P450 3A knockout mice can be attributed to up-regulated CYP2C enzymes. Mol Pharmacol. 2008 Mar; 73(3):1029-36. van Waterschoot RA, van Herwaarden AE, Lagas JS, Sparidans RW, Wagenaar E, van der Kruijssen CM, Goldstein JA, Zeldin DC, Beijnen JH, Schinkel AH. PMID: 18156313; PMCID: PMC2391091.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    26. The discovery of new coding alleles of human CYP26A1 that are potentially defective in the metabolism of all-trans retinoic acid and their assessment in a recombinant cDNA expression system. Pharmacogenet Genomics. 2007 Mar; 17(3):169-80. Lee SJ, Perera L, Coulter SJ, Mohrenweiser HW, Jetten A, Goldstein JA. PMID: 17460545; PMCID: PMC2393551.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    27. Detection of human CYP2C8, CYP2C9, and CYP2J2 in cardiovascular tissues. Drug Metab Dispos. 2007 Apr; 35(4):682-8. Delozier TC, Kissling GE, Coulter SJ, Dai D, Foley JF, Bradbury JA, Murphy E, Steenbergen C, Zeldin DC, Goldstein JA. PMID: 17220242; PMCID: PMC2747652.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    28. A new CYP3A5 variant, CYP3A5*11, is shown to be defective in nifedipine metabolism in a recombinant cDNA expression system. Drug Metab Dispos. 2007 Jan; 35(1):67-71. Lee SJ, van der Heiden IP, Goldstein JA, van Schaik RH. PMID: 17035598; PMCID: PMC3302370.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    29. Phenytoin induction of the cyp2c37 gene is mediated by the constitutive androstane receptor. Drug Metab Dispos. 2006 Dec; 34(12):2003-10. Jackson JP, Ferguson SS, Negishi M, Goldstein JA. PMID: 16936065; PMCID: PMC1676033.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    30. Enzyme-mediated protein haptenation of dapsone and sulfamethoxazole in human keratinocytes: I. Expression and role of cytochromes P450. J Pharmacol Exp Ther. 2006 Oct; 319(1):488-96. Vyas PM, Roychowdhury S, Khan FD, Prisinzano TE, Lamba J, Schuetz EG, Blaisdell J, Goldstein JA, Munson KL, Hines RN, Svensson CK. PMID: 16857728.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    31. Reduced methylprednisolone clearance causing prolonged pharmacodynamics in a healthy subject was not associated with CYP3A5*3 allele or a change in diet composition. J Clin Pharmacol. 2006 May; 46(5):515-26. Lee SJ, Jusko WJ, Salaita CG, Calis KA, Jann MW, Spratlin VE, Goldstein JA, Hon YY. PMID: 16638735; PMCID: PMC4182867.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    32. Functional characterization of novel allelic variants of CYP2C9 recently discovered in southeast Asians. J Pharmacol Exp Ther. 2005 Dec; 315(3):1085-90. DeLozier TC, Lee SC, Coulter SJ, Goh BC, Goldstein JA. PMID: 16099926.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    33. Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha. Mol Pharmacol. 2005 Sep; 68(3):747-57. Ferguson SS, Chen Y, LeCluyse EL, Negishi M, Goldstein JA. PMID: 15933212.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    34. Functionally defective or altered CYP3A4 and CYP3A5 single nucleotide polymorphisms and their detection with genotyping tests. Pharmacogenomics. 2005 Jun; 6(4):357-71. Lee SJ, Goldstein JA. PMID: 16004554.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    35. The nuclear receptors constitutive androstane receptor and pregnane X receptor cross-talk with hepatic nuclear factor 4alpha to synergistically activate the human CYP2C9 promoter. J Pharmacol Exp Ther. 2005 Sep; 314(3):1125-33. Chen Y, Kissling G, Negishi M, Goldstein JA. PMID: 15919766.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    36. Recombinant CYP3A4*17 is defective in metabolizing the hypertensive drug nifedipine, and the CYP3A4*17 allele may occur on the same chromosome as CYP3A5*3, representing a new putative defective CYP3A haplotype. J Pharmacol Exp Ther. 2005 Apr; 313(1):302-9. Lee SJ, Bell DA, Coulter SJ, Ghanayem B, Goldstein JA. PMID: 15634941.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    37. Single nucleotide polymorphisms in the CYP2J2 and CYP2C8 genes and the risk of hypertension. Pharmacogenet Genomics. 2005 Jan; 15(1):7-13. King LM, Gainer JV, David GL, Dai D, Goldstein JA, Brown NJ, Zeldin DC. PMID: 15864120.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    38. Discovery of new potentially defective alleles of human CYP2C9. Pharmacogenetics. 2004 Aug; 14(8):527-37. Blaisdell J, Jorge-Nebert LF, Coulter S, Ferguson SS, Lee SJ, Chanas B, Xi T, Mohrenweiser H, Ghanayem B, Goldstein JA. PMID: 15284535.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    39. The constitutive active/androstane receptor regulates phenytoin induction of Cyp2c29. Mol Pharmacol. 2004 Jun; 65(6):1397-404. Jackson JP, Ferguson SS, Moore R, Negishi M, Goldstein JA. PMID: 15155833.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    40. Cloning, expression, and characterization of three new mouse cytochrome p450 enzymes and partial characterization of their fatty acid oxidation activities. Mol Pharmacol. 2004 May; 65(5):1148-58. Wang H, Zhao Y, Bradbury JA, Graves JP, Foley J, Blaisdell JA, Goldstein JA, Zeldin DC. PMID: 15102943.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    41. CYP2C44, a new murine CYP2C that metabolizes arachidonic acid to unique stereospecific products. J Pharmacol Exp Ther. 2004 Sep; 310(3):845-54. DeLozier TC, Tsao CC, Coulter SJ, Foley J, Bradbury JA, Zeldin DC, Goldstein JA. PMID: 15084647.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    42. CYP2C9 genetic polymorphisms and warfarin. Clin Appl Thromb Hemost. 2004 Apr; 10(2):149-54. Redman AR, Dickmann LJ, Kidd RS, Goldstein JA, Ritchie DM, Hon YY. PMID: 15094935.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    43. Mouse liver CYP2C39 is a novel retinoic acid 4-hydroxylase. Its down-regulation offers a molecular basis for liver retinoid accumulation and fibrosis in aryl hydrocarbon receptor-null mice. J Biol Chem. 2004 Jan 30; 279(5):3434-8. Andreola F, Hayhurst GP, Luo G, Ferguson SS, Gonzalez FJ, Goldstein JA, De Luca LM. PMID: 14623888.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    44. Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor. J Pharmacol Exp Ther. 2004 Feb; 308(2):495-501. Chen Y, Ferguson SS, Negishi M, Goldstein JA. PMID: 14600250.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    45. Genetic findings and functional studies of human CYP3A5 single nucleotide polymorphisms in different ethnic groups. Pharmacogenetics. 2003 Aug; 13(8):461-72. Lee SJ, Usmani KA, Chanas B, Ghanayem B, Xi T, Hodgson E, Mohrenweiser HW, Goldstein JA. PMID: 12893984.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    46. Identification of constitutive androstane receptor and glucocorticoid receptor binding sites in the CYP2C19 promoter. Mol Pharmacol. 2003 Aug; 64(2):316-24. Chen Y, Ferguson SS, Negishi M, Goldstein JA. PMID: 12869636.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    47. Losartan and E3174 pharmacokinetics in cytochrome P450 2C9*1/*1, *1/*2, and *1/*3 individuals. Pharmacotherapy. 2003 Jun; 23(6):720-5. Lee CR, Pieper JA, Hinderliter AL, Blaisdell JA, Goldstein JA. PMID: 12820813.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    48. Differences in flurbiprofen pharmacokinetics between CYP2C9*1/*1, *1/*2, and *1/*3 genotypes. Eur J Clin Pharmacol. 2003 Apr; 58(12):791-4. Lee CR, Pieper JA, Frye RF, Hinderliter AL, Blaisdell JA, Goldstein JA. PMID: 12698304.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCTClinical Trials
    49. Tolbutamide, flurbiprofen, and losartan as probes of CYP2C9 activity in humans. J Clin Pharmacol. 2003 Jan; 43(1):84-91. Lee CR, Pieper JA, Frye RF, Hinderliter AL, Blaisdell JA, Goldstein JA. PMID: 12520632.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCTClinical Trials
    50. Identification and functional characterization of new potentially defective alleles of human CYP2C19. Pharmacogenetics. 2002 Dec; 12(9):703-11. Blaisdell J, Mohrenweiser H, Jackson J, Ferguson S, Coulter S, Chanas B, Xi T, Ghanayem B, Goldstein JA. PMID: 12464799.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    51. Evaluation of cytochrome P4502C9 metabolic activity with tolbutamide in CYP2C91 heterozygotes. Clin Pharmacol Ther. 2002 Nov; 72(5):562-71. Lee CR, Pieper JA, Hinderliter AL, Blaisdell JA, Goldstein JA. PMID: 12426520.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    52. Evaluation of potential losartan-phenytoin drug interactions in healthy volunteers. Clin Pharmacol Ther. 2002 Sep; 72(3):238-46. Fischer TL, Pieper JA, Graff DW, Rodgers JE, Fischer JD, Parnell KJ, Goldstein JA, Greenwood R, Patterson JH. PMID: 12235444.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCTClinical Trials
    53. Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site. Mol Pharmacol. 2002 Sep; 62(3):737-46. Ferguson SS, LeCluyse EL, Negishi M, Goldstein JA. PMID: 12181452.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    54. Analysis of the CYP2C19 polymorphism in a North-eastern Thai population. Pharmacogenetics. 2002 Apr; 12(3):221-5. Tassaneeyakul W, Tawalee A, Tassaneeyakul W, Kukongviriyapan V, Blaisdell J, Goldstein JA, Gaysornsiri D. PMID: 11927837.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    55. Cytochrome P450 2C9 polymorphisms: a comprehensive review of the in-vitro and human data. Pharmacogenetics. 2002 Apr; 12(3):251-63. Lee CR, Goldstein JA, Pieper JA. PMID: 11927841.
      View in: PubMed   Mentions: 175     Fields:    Translation:Humans
    56. CYP2C9 polymorphisms and CYP2C9*2 genotyping primers. Br J Clin Pharmacol. 2002 Apr; 53(4):409-10. Goldstein JA. PMID: 11966681; PMCID: PMC1874266.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    57. In vitro human metabolism and interactions of repellent N,N-diethyl-m-toluamide. Drug Metab Dispos. 2002 Mar; 30(3):289-94. Usmani KA, Rose RL, Goldstein JA, Taylor WG, Brimfield AA, Hodgson E. PMID: 11854147.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells