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CYP2C8 Is a Novel Target of Peroxisome Proliferator-Activated Receptor α in Human Liver. Mol Pharmacol. 2016 Jan; 89(1):154-64.
Makia NL, Goldstein JA. PMID: 26467040; PMCID: PMC4702104.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Epigenetic modification of histone 3 lysine 27: mediator subunit MED25 is required for the dissociation of polycomb repressive complex 2 from the promoter of cytochrome P450 2C9. J Biol Chem. 2015 Jan 23; 290(4):2264-78.
Englert NA, Luo G, Goldstein JA, Surapureddi S. PMID: 25391650; PMCID: PMC4303677.
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PubMed Mentions:
8 Fields:
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HumansAnimalsCells
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The influence of the CYP2C19*10 allele on clopidogrel activation and CYP2C19*2 genotyping. Pharmacogenet Genomics. 2014 Aug; 24(8):381-6.
Langaee TY, Zhu HJ, Wang X, El Rouby N, Markowitz JS, Goldstein JA, Johnson JA. PMID: 24945780; PMCID: PMC4090277.
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PubMed Mentions:
6 Fields:
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HumansCells
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Med25 is required for estrogen receptor alpha (ERα)-mediated regulation of human CYP2C9 expression. Biochem Pharmacol. 2014 Aug 15; 90(4):425-31.
Shi Z, Yang W, Goldstein JA, Zhang SY. PMID: 24960263; PMCID: PMC4292888.
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1 Fields:
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HumansCells
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Regulation of human CYP2C9 expression by electrophilic stress involves activator protein 1 activation and DNA looping. Mol Pharmacol. 2014 Aug; 86(2):125-37.
Makia NL, Surapureddi S, Monostory K, Prough RA, Goldstein JA. PMID: 24830941; PMCID: PMC4127925.
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PubMed Mentions:
6 Fields:
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HumansCells
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RBCK1, an E3 ubiquitin ligase, interacts with and ubiquinates the human pregnane X receptor. Drug Metab Dispos. 2013 Feb; 41(2):398-405.
Rana R, Coulter S, Kinyamu H, Goldstein JA. PMID: 23160820; PMCID: PMC3558864.
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PubMed Mentions:
19 Fields:
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HumansCells
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Associations of ABCB1 and IL-10 genetic polymorphisms with sirolimus-induced dyslipidemia in renal transplant recipients. Transplantation. 2012 Nov 15; 94(9):971-7.
Sam WJ, Chamberlain CE, Lee SJ, Goldstein JA, Hale DA, Mannon RB, Kirk AD, Hon YY. PMID: 23073467; PMCID: PMC3491093.
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PubMed Mentions:
5 Fields:
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Humans
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Cyclophosphamide and 4-hydroxycyclophosphamide pharmacokinetics in patients with glomerulonephritis secondary to lupus and small vessel vasculitis. Br J Clin Pharmacol. 2012 Sep; 74(3):445-55.
Joy MS, La M, Wang J, Bridges AS, Hu Y, Hogan SL, Frye RF, Blaisdell J, Goldstein JA, Dooley MA, Brouwer KL, Falk RJ. PMID: 22380717; PMCID: PMC3477346.
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PubMed Mentions:
23 Fields:
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Humans
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Human CYP2C8 is post-transcriptionally regulated by microRNAs 103 and 107 in human liver. Mol Pharmacol. 2012 Sep; 82(3):529-40.
Zhang SY, Surapureddi S, Coulter S, Ferguson SS, Goldstein JA. PMID: 22723340; PMCID: PMC3422698.
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32 Fields:
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HumansCells
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Comparison of CYP3A4 and CYP3A5: the effects of cytochrome b5 and NADPH-cytochrome P450 reductase on testosterone hydroxylation activities. Drug Metab Pharmacokinet. 2012; 27(6):663-7.
Lee SJ, Goldstein JA. PMID: 22785258; PMCID: PMC3602955.
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PubMed Mentions:
5 Fields:
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Cells
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P2X7 receptor-NADPH oxidase axis mediates protein radical formation and Kupffer cell activation in carbon tetrachloride-mediated steatohepatitis in obese mice. Free Radic Biol Med. 2012 May 01; 52(9):1666-79.
Chatterjee S, Rana R, Corbett J, Kadiiska MB, Goldstein J, Mason RP. PMID: 22343416; PMCID: PMC3341527.
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PubMed Mentions:
36 Fields:
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AnimalsCells
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Associations of ABCB1 3435C>T and IL-10-1082G>A polymorphisms with long-term sirolimus dose requirements in renal transplant patients. Transplantation. 2011 Dec 27; 92(12):1342-7.
Sam WJ, Chamberlain CE, Lee SJ, Goldstein JA, Hale DA, Mannon RB, Kirk AD, Hon YY. PMID: 22094953; PMCID: PMC3237821.
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PubMed Mentions:
9 Fields:
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Humans
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Liganded pregnane X receptor represses the human sulfotransferase SULT1E1 promoter through disrupting its chromatin structure. Nucleic Acids Res. 2011 Oct; 39(19):8392-403.
Kodama S, Hosseinpour F, Goldstein JA, Negishi M. PMID: 21764778; PMCID: PMC3201858.
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PubMed Mentions:
25 Fields:
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HumansCells
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NCOA6 differentially regulates the expression of the CYP2C9 and CYP3A4 genes. Pharmacol Res. 2011 May; 63(5):405-13.
Surapureddi S, Rana R, Goldstein JA. PMID: 21292004; PMCID: PMC3082001.
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PubMed Mentions:
7 Fields:
Translation:
HumansCells
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Med25 is required for RNA polymerase II recruitment to specific promoters, thus regulating xenobiotic and lipid metabolism in human liver. Mol Cell Biol. 2011 Feb; 31(3):466-81.
Rana R, Surapureddi S, Kam W, Ferguson S, Goldstein JA. PMID: 21135126; PMCID: PMC3028616.
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PubMed Mentions:
34 Fields:
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HumansCells
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The nuclear receptors constitutive active/androstane receptor and pregnane x receptor activate the Cyp2c55 gene in mouse liver. Drug Metab Dispos. 2010 Jul; 38(7):1177-82.
Konno Y, Kamino H, Moore R, Lih F, Tomer KB, Zeldin DC, Goldstein JA, Negishi M. PMID: 20371638; PMCID: PMC2908984.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Hepatocyte nuclear factor 4{alpha} regulates rifampicin-mediated induction of CYP2C genes in primary cultures of human hepatocytes. Drug Metab Dispos. 2010 Apr; 38(4):591-9.
Rana R, Chen Y, Ferguson SS, Kissling GE, Surapureddi S, Goldstein JA. PMID: 20086032; PMCID: PMC2845933.
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PubMed Mentions:
16 Fields:
Translation:
HumansCells
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CYP2C9 genotype and pharmacodynamic responses to losartan in patients with primary and secondary kidney diseases. Eur J Clin Pharmacol. 2009 Sep; 65(9):947-53.
Joy MS, Dornbrook-Lavender K, Blaisdell J, Hilliard T, Boyette T, Hu Y, Hogan SL, Candiani C, Falk RJ, Goldstein JA. PMID: 19669737; PMCID: PMC2901912.
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PubMed Mentions:
14 Fields:
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Humans
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The transcriptional regulation of the human CYP2C genes. Curr Drug Metab. 2009 Jul; 10(6):567-78.
Chen Y, Goldstein JA. PMID: 19702536; PMCID: PMC2808111.
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41 Fields:
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Humans
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Kidney function influences warfarin responsiveness and hemorrhagic complications. J Am Soc Nephrol. 2009 Apr; 20(4):912-21.
Limdi NA, Beasley TM, Baird MF, Goldstein JA, McGwin G, Arnett DK, Acton RT, Allon M. PMID: 19225037; PMCID: PMC2663833.
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PubMed Mentions:
91 Fields:
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Humans
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Identification of human CYP2C8 as a retinoid-related orphan nuclear receptor target gene. J Pharmacol Exp Ther. 2009 Apr; 329(1):192-201.
Chen Y, Coulter S, Jetten AM, Goldstein JA. PMID: 19164466; PMCID: PMC2670598.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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VKORC1 polymorphisms, haplotypes and haplotype groups on warfarin dose among African-Americans and European-Americans. Pharmacogenomics. 2008 Oct; 9(10):1445-58.
Limdi NA, Beasley TM, Crowley MR, Goldstein JA, Rieder MJ, Flockhart DA, Arnett DK, Acton RT, Liu N. PMID: 18855533; PMCID: PMC2586955.
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PubMed Mentions:
65 Fields:
Translation:
Humans
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Nuclear receptor coactivator 6 mediates the synergistic activation of human cytochrome P-450 2C9 by the constitutive androstane receptor and hepatic nuclear factor-4alpha. Mol Pharmacol. 2008 Sep; 74(3):913-23.
Surapureddi S, Rana R, Reddy JK, Goldstein JA. PMID: 18552123; PMCID: PMC3815599.
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17 Fields:
Translation:
HumansCells
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Influence of CYP2C9 and VKORC1 on warfarin dose, anticoagulation attainment and maintenance among European-Americans and African-Americans. Pharmacogenomics. 2008 May; 9(5):511-26.
Limdi NA, Arnett DK, Goldstein JA, Beasley TM, McGwin G, Adler BK, Acton RT. PMID: 18466099; PMCID: PMC2757655.
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PubMed Mentions:
81 Fields:
Translation:
Humans
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Midazolam metabolism in cytochrome P450 3A knockout mice can be attributed to up-regulated CYP2C enzymes. Mol Pharmacol. 2008 Mar; 73(3):1029-36.
van Waterschoot RA, van Herwaarden AE, Lagas JS, Sparidans RW, Wagenaar E, van der Kruijssen CM, Goldstein JA, Zeldin DC, Beijnen JH, Schinkel AH. PMID: 18156313; PMCID: PMC2391091.
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PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
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The discovery of new coding alleles of human CYP26A1 that are potentially defective in the metabolism of all-trans retinoic acid and their assessment in a recombinant cDNA expression system. Pharmacogenet Genomics. 2007 Mar; 17(3):169-80.
Lee SJ, Perera L, Coulter SJ, Mohrenweiser HW, Jetten A, Goldstein JA. PMID: 17460545; PMCID: PMC2393551.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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Detection of human CYP2C8, CYP2C9, and CYP2J2 in cardiovascular tissues. Drug Metab Dispos. 2007 Apr; 35(4):682-8.
Delozier TC, Kissling GE, Coulter SJ, Dai D, Foley JF, Bradbury JA, Murphy E, Steenbergen C, Zeldin DC, Goldstein JA. PMID: 17220242; PMCID: PMC2747652.
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PubMed Mentions:
56 Fields:
Translation:
Humans
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A new CYP3A5 variant, CYP3A5*11, is shown to be defective in nifedipine metabolism in a recombinant cDNA expression system. Drug Metab Dispos. 2007 Jan; 35(1):67-71.
Lee SJ, van der Heiden IP, Goldstein JA, van Schaik RH. PMID: 17035598; PMCID: PMC3302370.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Phenytoin induction of the cyp2c37 gene is mediated by the constitutive androstane receptor. Drug Metab Dispos. 2006 Dec; 34(12):2003-10.
Jackson JP, Ferguson SS, Negishi M, Goldstein JA. PMID: 16936065; PMCID: PMC1676033.
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PubMed Mentions:
21 Fields:
Translation:
Animals
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Enzyme-mediated protein haptenation of dapsone and sulfamethoxazole in human keratinocytes: I. Expression and role of cytochromes P450. J Pharmacol Exp Ther. 2006 Oct; 319(1):488-96.
Vyas PM, Roychowdhury S, Khan FD, Prisinzano TE, Lamba J, Schuetz EG, Blaisdell J, Goldstein JA, Munson KL, Hines RN, Svensson CK. PMID: 16857728.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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Reduced methylprednisolone clearance causing prolonged pharmacodynamics in a healthy subject was not associated with CYP3A5*3 allele or a change in diet composition. J Clin Pharmacol. 2006 May; 46(5):515-26.
Lee SJ, Jusko WJ, Salaita CG, Calis KA, Jann MW, Spratlin VE, Goldstein JA, Hon YY. PMID: 16638735; PMCID: PMC4182867.
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PubMed Mentions:
6 Fields:
Translation:
Humans
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Functional characterization of novel allelic variants of CYP2C9 recently discovered in southeast Asians. J Pharmacol Exp Ther. 2005 Dec; 315(3):1085-90.
DeLozier TC, Lee SC, Coulter SJ, Goh BC, Goldstein JA. PMID: 16099926.
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PubMed Mentions:
23 Fields:
Translation:
HumansCells
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Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha. Mol Pharmacol. 2005 Sep; 68(3):747-57.
Ferguson SS, Chen Y, LeCluyse EL, Negishi M, Goldstein JA. PMID: 15933212.
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PubMed Mentions:
50 Fields:
Translation:
HumansCells
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Functionally defective or altered CYP3A4 and CYP3A5 single nucleotide polymorphisms and their detection with genotyping tests. Pharmacogenomics. 2005 Jun; 6(4):357-71.
Lee SJ, Goldstein JA. PMID: 16004554.
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PubMed Mentions:
40 Fields:
Translation:
Humans
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The nuclear receptors constitutive androstane receptor and pregnane X receptor cross-talk with hepatic nuclear factor 4alpha to synergistically activate the human CYP2C9 promoter. J Pharmacol Exp Ther. 2005 Sep; 314(3):1125-33.
Chen Y, Kissling G, Negishi M, Goldstein JA. PMID: 15919766.
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PubMed Mentions:
34 Fields:
Translation:
HumansCells
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Recombinant CYP3A4*17 is defective in metabolizing the hypertensive drug nifedipine, and the CYP3A4*17 allele may occur on the same chromosome as CYP3A5*3, representing a new putative defective CYP3A haplotype. J Pharmacol Exp Ther. 2005 Apr; 313(1):302-9.
Lee SJ, Bell DA, Coulter SJ, Ghanayem B, Goldstein JA. PMID: 15634941.
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PubMed Mentions:
17 Fields:
Translation:
HumansCells
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Single nucleotide polymorphisms in the CYP2J2 and CYP2C8 genes and the risk of hypertension. Pharmacogenet Genomics. 2005 Jan; 15(1):7-13.
King LM, Gainer JV, David GL, Dai D, Goldstein JA, Brown NJ, Zeldin DC. PMID: 15864120.
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PubMed Mentions:
41 Fields:
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Humans
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Discovery of new potentially defective alleles of human CYP2C9. Pharmacogenetics. 2004 Aug; 14(8):527-37.
Blaisdell J, Jorge-Nebert LF, Coulter S, Ferguson SS, Lee SJ, Chanas B, Xi T, Mohrenweiser H, Ghanayem B, Goldstein JA. PMID: 15284535.
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PubMed Mentions:
50 Fields:
Translation:
Humans
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The constitutive active/androstane receptor regulates phenytoin induction of Cyp2c29. Mol Pharmacol. 2004 Jun; 65(6):1397-404.
Jackson JP, Ferguson SS, Moore R, Negishi M, Goldstein JA. PMID: 15155833.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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Cloning, expression, and characterization of three new mouse cytochrome p450 enzymes and partial characterization of their fatty acid oxidation activities. Mol Pharmacol. 2004 May; 65(5):1148-58.
Wang H, Zhao Y, Bradbury JA, Graves JP, Foley J, Blaisdell JA, Goldstein JA, Zeldin DC. PMID: 15102943.
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PubMed Mentions:
37 Fields:
Translation:
AnimalsCells
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CYP2C44, a new murine CYP2C that metabolizes arachidonic acid to unique stereospecific products. J Pharmacol Exp Ther. 2004 Sep; 310(3):845-54.
DeLozier TC, Tsao CC, Coulter SJ, Foley J, Bradbury JA, Zeldin DC, Goldstein JA. PMID: 15084647.
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PubMed Mentions:
41 Fields:
Translation:
AnimalsCells
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CYP2C9 genetic polymorphisms and warfarin. Clin Appl Thromb Hemost. 2004 Apr; 10(2):149-54.
Redman AR, Dickmann LJ, Kidd RS, Goldstein JA, Ritchie DM, Hon YY. PMID: 15094935.
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PubMed Mentions:
8 Fields:
Translation:
Humans
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Mouse liver CYP2C39 is a novel retinoic acid 4-hydroxylase. Its down-regulation offers a molecular basis for liver retinoid accumulation and fibrosis in aryl hydrocarbon receptor-null mice. J Biol Chem. 2004 Jan 30; 279(5):3434-8.
Andreola F, Hayhurst GP, Luo G, Ferguson SS, Gonzalez FJ, Goldstein JA, De Luca LM. PMID: 14623888.
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PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
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Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor. J Pharmacol Exp Ther. 2004 Feb; 308(2):495-501.
Chen Y, Ferguson SS, Negishi M, Goldstein JA. PMID: 14600250.
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PubMed Mentions:
60 Fields:
Translation:
HumansCells
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Identification of constitutive androstane receptor and glucocorticoid receptor binding sites in the CYP2C19 promoter. Mol Pharmacol. 2003 Aug; 64(2):316-24.
Chen Y, Ferguson SS, Negishi M, Goldstein JA. PMID: 12869636.
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PubMed Mentions:
50 Fields:
Translation:
HumansCells
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Genetic findings and functional studies of human CYP3A5 single nucleotide polymorphisms in different ethnic groups. Pharmacogenetics. 2003 Aug; 13(8):461-72.
Lee SJ, Usmani KA, Chanas B, Ghanayem B, Xi T, Hodgson E, Mohrenweiser HW, Goldstein JA. PMID: 12893984.
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PubMed Mentions:
42 Fields:
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HumansCells
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Losartan and E3174 pharmacokinetics in cytochrome P450 2C9*1/*1, *1/*2, and *1/*3 individuals. Pharmacotherapy. 2003 Jun; 23(6):720-5.
Lee CR, Pieper JA, Hinderliter AL, Blaisdell JA, Goldstein JA. PMID: 12820813.
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PubMed Mentions:
6 Fields:
Translation:
Humans
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Differences in flurbiprofen pharmacokinetics between CYP2C9*1/*1, *1/*2, and *1/*3 genotypes. Eur J Clin Pharmacol. 2003 Apr; 58(12):791-4.
Lee CR, Pieper JA, Frye RF, Hinderliter AL, Blaisdell JA, Goldstein JA. PMID: 12698304.
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PubMed Mentions:
20 Fields:
Translation:
HumansCTClinical Trials
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Tolbutamide, flurbiprofen, and losartan as probes of CYP2C9 activity in humans. J Clin Pharmacol. 2003 Jan; 43(1):84-91.
Lee CR, Pieper JA, Frye RF, Hinderliter AL, Blaisdell JA, Goldstein JA. PMID: 12520632.
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PubMed Mentions:
27 Fields:
Translation:
HumansCTClinical Trials
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Identification and functional characterization of new potentially defective alleles of human CYP2C19. Pharmacogenetics. 2002 Dec; 12(9):703-11.
Blaisdell J, Mohrenweiser H, Jackson J, Ferguson S, Coulter S, Chanas B, Xi T, Ghanayem B, Goldstein JA. PMID: 12464799.
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PubMed Mentions:
30 Fields:
Translation:
HumansCells
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Evaluation of potential losartan-phenytoin drug interactions in healthy volunteers. Clin Pharmacol Ther. 2002 Sep; 72(3):238-46.
Fischer TL, Pieper JA, Graff DW, Rodgers JE, Fischer JD, Parnell KJ, Goldstein JA, Greenwood R, Patterson JH. PMID: 12235444.
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PubMed Mentions:
8 Fields:
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HumansCTClinical Trials
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Cytochrome P450 2C9 polymorphisms: a comprehensive review of the in-vitro and human data. Pharmacogenetics. 2002 Apr; 12(3):251-63.
Lee CR, Goldstein JA, Pieper JA. PMID: 11927841.
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PubMed Mentions:
187 Fields:
Translation:
Humans
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Analysis of the CYP2C19 polymorphism in a North-eastern Thai population. Pharmacogenetics. 2002 Apr; 12(3):221-5.
Tassaneeyakul W, Tawalee A, Tassaneeyakul W, Kukongviriyapan V, Blaisdell J, Goldstein JA, Gaysornsiri D. PMID: 11927837.
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PubMed Mentions:
13 Fields:
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Humans
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In vitro human metabolism and interactions of repellent N,N-diethyl-m-toluamide. Drug Metab Dispos. 2002 Mar; 30(3):289-94.
Usmani KA, Rose RL, Goldstein JA, Taylor WG, Brimfield AA, Hodgson E. PMID: 11854147.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells