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Derek S. Sieburth, PhD

Title(s)Associate Professor of Physiology & Neuroscience
Phone+1 323 442 2013
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    Collapse Overview 
    Collapse Overview
    The Sieburth lab studies synaptic signaling pathways that regulate synaptic function, with the goal of understanding how these pathways contribute to the function of neuronal circuits controlling behavioral programs in the nervous system. My laboratory uses C. elegans as a model organism for studying synaptic biology, because of its simple neuronal circuitry, the ability to visualize synapses by fluorescent imaging in live animals, and its powerful genetics. We combine state of-the-art behavioral, genetic, cell biological, and in vivo neuronal imaging techniques in to study the cellular molecular mechanisms underlying secretion of synaptic vesicles and dense core vesicles. My lab is interested in three major areas: 1) How does localized sphingolipid signaling at presynaptic terminals regulate synaptic transmission at neuromuscular junctions, 2) The mechanisms by which oxidative stress regulates synaptic transmission and behavior, and 3) How does a neuropeptide signaling pathway deliver timing information from a pacemaker to activate a rhythmic behavioral circuit.

    Collapse Research 
    Collapse Research Activities and Funding
    Sphingolipid signaling in mitochondrial surveillance
    NIH/NINDS R01NS110730Sep 15, 2019 - Aug 31, 2024
    Role: Principal Investigator
    Stress Regulation of Synaptic Transmission
    NIH/NINDS R01NS099414Apr 1, 2017 - Mar 31, 2021
    Role: Principal Investigator
    Stress Regulation of Synaptic Transmission
    NIH/NINDS R56NS071085Jul 1, 2010 - Mar 31, 2017
    Role: Principal Investigator
    Stress Regulation of Synaptic Transmission
    NIH/NINDS R01NS071085Jul 1, 2010 - Jun 30, 2015
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Kim S, Sieburth D. A Receptor Tyrosine Kinase Network Regulates Neuromuscular Function in Response to Oxidative Stress in Caenorhabditis elegans. Genetics. 2019 04; 211(4):1283-1295. PMID: 30782598.
      View in: PubMed
    2. Kim S, Sieburth D. Sphingosine Kinase Activates the Mitochondrial Unfolded Protein Response and Is Targeted to Mitochondria by Stress. Cell Rep. 2018 Sep 11; 24(11):2932-2945.e4. PMID: 30208318.
      View in: PubMed
    3. Kim S, Sieburth D. Sphingosine Kinase Regulates Neuropeptide Secretion During the Oxidative Stress-Response Through Intertissue Signaling. J Neurosci. 2018 09 19; 38(38):8160-8176. PMID: 30082417.
      View in: PubMed
    4. Raynes R, Juarez C, Pomatto LC, Sieburth D, Davies KJ. Aging and SKN-1-dependent Loss of 20S Proteasome Adaptation to Oxidative Stress in C. elegans. J Gerontol A Biol Sci Med Sci. 2017 02; 72(2):143-151. PMID: 27341854.
      View in: PubMed
    5. Shen H, Giordano F, Wu Y, Chan J, Zhu C, Milosevic I, Wu X, Yao K, Chen B, Baumgart T, Sieburth D, De Camilli P. Coupling between endocytosis and sphingosine kinase 1 recruitment. Nat Cell Biol. 2014 Jul; 16(7):652-62. PMID: 24929359.
      View in: PubMed
    6. Staab TA, Evgrafov O, Egrafov O, Knowles JA, Sieburth D. Regulation of synaptic nlg-1/neuroligin abundance by the skn-1/Nrf stress response pathway protects against oxidative stress. PLoS Genet. 2014 Jan; 10(1):e1004100. PMID: 24453991.
      View in: PubMed
    7. Wang H, Sieburth D. PKA controls calcium influx into motor neurons during a rhythmic behavior. PLoS Genet. 2013; 9(9):e1003831. PMID: 24086161.
      View in: PubMed
    8. Chan JP, Staab TA, Wang H, Mazzasette C, Butte Z, Sieburth D. Extrasynaptic muscarinic acetylcholine receptors on neuronal cell bodies regulate presynaptic function in Caenorhabditis elegans. J Neurosci. 2013 Aug 28; 33(35):14146-59. PMID: 23986249.
      View in: PubMed
    9. Wang H, Girskis K, Janssen T, Chan JP, Dasgupta K, Knowles JA, Schoofs L, Sieburth D. Neuropeptide secreted from a pacemaker activates neurons to control a rhythmic behavior. Curr Biol. 2013 May 06; 23(9):746-54. PMID: 23583549.
      View in: PubMed
    10. Staab TA, Griffen TC, Corcoran C, Evgrafov O, Knowles JA, Sieburth D. The conserved SKN-1/Nrf2 stress response pathway regulates synaptic function in Caenorhabditis elegans. PLoS Genet. 2013 Mar; 9(3):e1003354. PMID: 23555279.
      View in: PubMed
    11. Chan JP, Sieburth D. Localized sphingolipid signaling at presynaptic terminals is regulated by calcium influx and promotes recruitment of priming factors. J Neurosci. 2012 Dec 05; 32(49):17909-20. PMID: 23223309.
      View in: PubMed
    12. Pickering AM, Staab TA, Tower J, Sieburth D, Davies KJ. A conserved role for the 20S proteasome and Nrf2 transcription factor in oxidative stress adaptation in mammals, Caenorhabditis elegans and Drosophila melanogaster. J Exp Biol. 2013 Feb 15; 216(Pt 4):543-53. PMID: 23038734.
      View in: PubMed
    13. Chan JP, Hu Z, Sieburth D. Recruitment of sphingosine kinase to presynaptic terminals by a conserved muscarinic signaling pathway promotes neurotransmitter release. Genes Dev. 2012 May 15; 26(10):1070-85. PMID: 22588719.
      View in: PubMed
    14. Hao Y, Hu Z, Sieburth D, Kaplan JM. RIC-7 promotes neuropeptide secretion. PLoS Genet. 2012 Jan; 8(1):e1002464. PMID: 22275875.
      View in: PubMed
    15. Bedrood S, Jayasinghe S, Sieburth D, Chen M, Erbel S, Butler PC, Langen R, Ritzel RA. Annexin A5 directly interacts with amyloidogenic proteins and reduces their toxicity. Biochemistry. 2009 Nov 10; 48(44):10568-76. PMID: 19810772.
      View in: PubMed
    16. Ch'ng Q, Sieburth D, Kaplan JM. Profiling synaptic proteins identifies regulators of insulin secretion and lifespan. PLoS Genet. 2008 Nov; 4(11):e1000283. PMID: 19043554.
      View in: PubMed
    17. Vashlishan AB, Madison JM, Dybbs M, Bai J, Sieburth D, Ch'ng Q, Tavazoie M, Kaplan JM. An RNAi screen identifies genes that regulate GABA synapses. Neuron. 2008 May 08; 58(3):346-61. PMID: 18466746.
      View in: PubMed
    18. Sieburth D, Madison JM, Kaplan JM. PKC-1 regulates secretion of neuropeptides. Nat Neurosci. 2007 Jan; 10(1):49-57. PMID: 17128266.
      View in: PubMed
    19. Sieburth D, Ch'ng Q, Dybbs M, Tavazoie M, Kennedy S, Wang D, Dupuy D, Rual JF, Hill DE, Vidal M, Ruvkun G, Kaplan JM. Systematic analysis of genes required for synapse structure and function. Nature. 2005 Jul 28; 436(7050):510-7. PMID: 16049479.
      View in: PubMed
    20. Sieburth DS, Sundaram M, Howard RM, Han M. A PP2A regulatory subunit positively regulates Ras-mediated signaling during Caenorhabditis elegans vulval induction. Genes Dev. 1999 Oct 01; 13(19):2562-9. PMID: 10521400.
      View in: PubMed
    21. Sieburth DS, Sun Q, Han M. SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans. Cell. 1998 Jul 10; 94(1):119-30. PMID: 9674433.
      View in: PubMed
    22. Fulton SA, Johnsen JM, Wolf SF, Sieburth DS, Boom WH. Interleukin-12 production by human monocytes infected with Mycobacterium tuberculosis: role of phagocytosis. Infect Immun. 1996 Jul; 64(7):2523-31. PMID: 8698475.
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    23. Sypek JP, Chung CL, Mayor SE, Subramanyam JM, Goldman SJ, Sieburth DS, Wolf SF, Schaub RG. Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response. J Exp Med. 1993 Jun 01; 177(6):1797-802. PMID: 8098733.
      View in: PubMed