Derek S. Sieburth, PhD

Title(s)Associate Professor of Physiology & Neuroscience
SchoolKeck School of Medicine of Usc
AddressZNI 213, 1501 San Pablo Street
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 2013
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    The Sieburth lab studies signaling pathways that regulate neuronal function, with the goal of understanding how these pathways contribute to the function of neuronal circuits controlling behavioral programs in the nervous system. My laboratory uses C. elegans as a model organism for studying neuronal function, because of its simple neuronal circuitry, the ability to visualize synapses and neurotransmitters by fluorescent imaging in live animals, and its powerful genetics. We combine state of-the-art behavioral, genetic, cell biological, and in vivo neuronal imaging techniques in to study the cellular molecular mechanisms underlying secretion of synaptic vesicles and dense core vesicles. The lab is interested in three major areas: 1) What are the molecular mechanisms underlying the regulation of neuropeptide storage and secretion from dense core vesicles? 2) What are the mechanisms by which oxidative stress regulates neurotransmitter secretion and stress responses, and 3) How does sphingolipid signaling control mitochondrial homeostasis in response to neuronal stress? Many of the genes we study are conserved in mammals, so our studies provide novel insight into the mechanisms by which neurotransmitter secretion may be regulated in humans.
    To visit the Sieburth lab website go here:
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    Sphingolipid signaling in mitochondrial surveillance
    NIH R01NS110730Sep 15, 2019 - Aug 31, 2024
    Role: Principal Investigator
    Stress Regulation of Synaptic Transmission
    NIH R01NS099414Apr 1, 2017 - Mar 31, 2021
    Role: Principal Investigator
    Stress Regulation of Synaptic Transmission
    NIH R56NS071085Jul 1, 2010 - Mar 31, 2018
    Role: Principal Investigator
    Stress Regulation of Synaptic Transmission
    NIH R01NS071085Jul 1, 2010 - Jun 30, 2016
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The head mesodermal cell couples FMRFamide neuropeptide signaling with rhythmic muscle contraction in C. elegans. Nat Commun. 2023 07 14; 14(1):4218. Choi U, Hu M, Zhang Q, Sieburth D. PMID: 37452027; PMCID: PMC10349088.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    2. Presynaptic coupling by electrical synapses coordinates a rhythmic behavior by synchronizing the activities of a neuron pair. Proc Natl Acad Sci U S A. 2021 05 18; 118(20). Choi U, Wang H, Hu M, Kim S, Sieburth D. PMID: 33972428; PMCID: PMC8157971.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    3. Mitochondrial hydrogen peroxide positively regulates neuropeptide secretion during diet-induced activation of the oxidative stress response. Nat Commun. 2021 04 16; 12(1):2304. Jia Q, Sieburth D. PMID: 33863916; PMCID: PMC8052458.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    4. FSHR-1/GPCR Regulates the Mitochondrial Unfolded Protein Response in Caenorhabditis elegans. Genetics. 2020 02; 214(2):409-418. Kim S, Sieburth D. PMID: 31801834; PMCID: PMC7017012.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    5. A Receptor Tyrosine Kinase Network Regulates Neuromuscular Function in Response to Oxidative Stress in Caenorhabditis elegans. Genetics. 2019 04; 211(4):1283-1295. Kim S, Sieburth D. PMID: 30782598; PMCID: PMC6456306.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    6. Sphingosine Kinase Activates the Mitochondrial Unfolded Protein Response and Is Targeted to Mitochondria by Stress. Cell Rep. 2018 09 11; 24(11):2932-2945.e4. Kim S, Sieburth D. PMID: 30208318; PMCID: PMC6206875.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    7. Sphingosine Kinase Regulates Neuropeptide Secretion During the Oxidative Stress-Response Through Intertissue Signaling. J Neurosci. 2018 09 19; 38(38):8160-8176. Kim S, Sieburth D. PMID: 30082417; PMCID: PMC6146497.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    8. nu444 is a novel allele of pkc-1 in C. elegans. MicroPubl Biol. 2017 May 18; 2017. Wang H, Sieburth D. PMID: 32550344; PMCID: PMC7255862.
      View in: PubMed   Mentions:
    9. Aging and SKN-1-dependent Loss of 20S Proteasome Adaptation to Oxidative Stress in C. elegans. J Gerontol A Biol Sci Med Sci. 2017 02; 72(2):143-151. Raynes R, Juarez C, Pomatto LC, Sieburth D, Davies KJ. PMID: 27341854; PMCID: PMC5233911.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    10. Coupling between endocytosis and sphingosine kinase 1 recruitment. Nat Cell Biol. 2014 Jul; 16(7):652-62. Shen H, Giordano F, Wu Y, Chan J, Zhu C, Milosevic I, Wu X, Yao K, Chen B, Baumgart T, Sieburth D, De Camilli P. PMID: 24929359; PMCID: PMC4230894.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    11. Regulation of synaptic nlg-1/neuroligin abundance by the skn-1/Nrf stress response pathway protects against oxidative stress. PLoS Genet. 2014 Jan; 10(1):e1004100. Staab TA, Evgrafov O, Egrafov O, Knowles JA, Sieburth D. PMID: 24453991; PMCID: PMC3894169.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    12. PKA controls calcium influx into motor neurons during a rhythmic behavior. PLoS Genet. 2013; 9(9):e1003831. Wang H, Sieburth D. PMID: 24086161; PMCID: PMC3784516.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    13. Extrasynaptic muscarinic acetylcholine receptors on neuronal cell bodies regulate presynaptic function in Caenorhabditis elegans. J Neurosci. 2013 Aug 28; 33(35):14146-59. Chan JP, Staab TA, Wang H, Mazzasette C, Butte Z, Sieburth D. PMID: 23986249; PMCID: PMC3756759.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    14. Neuropeptide secreted from a pacemaker activates neurons to control a rhythmic behavior. Curr Biol. 2013 May 06; 23(9):746-54. Wang H, Girskis K, Janssen T, Chan JP, Dasgupta K, Knowles JA, Schoofs L, Sieburth D. PMID: 23583549; PMCID: PMC3651789.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    15. The conserved SKN-1/Nrf2 stress response pathway regulates synaptic function in Caenorhabditis elegans. PLoS Genet. 2013 Mar; 9(3):e1003354. Staab TA, Griffen TC, Corcoran C, Evgrafov O, Knowles JA, Sieburth D. PMID: 23555279; PMCID: PMC3605294.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    16. Localized sphingolipid signaling at presynaptic terminals is regulated by calcium influx and promotes recruitment of priming factors. J Neurosci. 2012 Dec 05; 32(49):17909-20. Chan JP, Sieburth D. PMID: 23223309; PMCID: PMC3545516.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    17. A conserved role for the 20S proteasome and Nrf2 transcription factor in oxidative stress adaptation in mammals, Caenorhabditis elegans and Drosophila melanogaster. J Exp Biol. 2013 Feb 15; 216(Pt 4):543-53. Pickering AM, Staab TA, Tower J, Sieburth D, Davies KJ. PMID: 23038734; PMCID: PMC3561776.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    18. Recruitment of sphingosine kinase to presynaptic terminals by a conserved muscarinic signaling pathway promotes neurotransmitter release. Genes Dev. 2012 May 15; 26(10):1070-85. Chan JP, Hu Z, Sieburth D. PMID: 22588719; PMCID: PMC3360562.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    19. RIC-7 promotes neuropeptide secretion. PLoS Genet. 2012 Jan; 8(1):e1002464. Hao Y, Hu Z, Sieburth D, Kaplan JM. PMID: 22275875; PMCID: PMC3261915.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    20. Annexin A5 directly interacts with amyloidogenic proteins and reduces their toxicity. Biochemistry. 2009 Nov 10; 48(44):10568-76. Bedrood S, Jayasinghe S, Sieburth D, Chen M, Erbel S, Butler PC, Langen R, Ritzel RA. PMID: 19810772; PMCID: PMC4394648.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    21. Profiling synaptic proteins identifies regulators of insulin secretion and lifespan. PLoS Genet. 2008 Nov; 4(11):e1000283. Ch'ng Q, Sieburth D, Kaplan JM. PMID: 19043554; PMCID: PMC2582949.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    22. An RNAi screen identifies genes that regulate GABA synapses. Neuron. 2008 May 08; 58(3):346-61. Vashlishan AB, Madison JM, Dybbs M, Bai J, Sieburth D, Ch'ng Q, Tavazoie M, Kaplan JM. PMID: 18466746.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    23. PKC-1 regulates secretion of neuropeptides. Nat Neurosci. 2007 Jan; 10(1):49-57. Sieburth D, Madison JM, Kaplan JM. PMID: 17128266.
      View in: PubMed   Mentions: 148     Fields:    Translation:AnimalsCells
    24. Systematic analysis of genes required for synapse structure and function. Nature. 2005 Jul 28; 436(7050):510-7. Sieburth D, Ch'ng Q, Dybbs M, Tavazoie M, Kennedy S, Wang D, Dupuy D, Rual JF, Hill DE, Vidal M, Ruvkun G, Kaplan JM. PMID: 16049479.
      View in: PubMed   Mentions: 199     Fields:    Translation:AnimalsCells
    25. A PP2A regulatory subunit positively regulates Ras-mediated signaling during Caenorhabditis elegans vulval induction. Genes Dev. 1999 Oct 01; 13(19):2562-9. Sieburth DS, Sundaram M, Howard RM, Han M. PMID: 10521400; PMCID: PMC317062.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    26. SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans. Cell. 1998 Jul 10; 94(1):119-30. Sieburth DS, Sun Q, Han M. PMID: 9674433.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    27. Interleukin-12 production by human monocytes infected with Mycobacterium tuberculosis: role of phagocytosis. Infect Immun. 1996 Jul; 64(7):2523-31. Fulton SA, Johnsen JM, Wolf SF, Sieburth DS, Boom WH. PMID: 8698475; PMCID: PMC174106.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    28. Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response. J Exp Med. 1993 Jun 01; 177(6):1797-802. Sypek JP, Chung CL, Mayor SE, Subramanyam JM, Goldman SJ, Sieburth DS, Wolf SF, Schaub RG. PMID: 8098733; PMCID: PMC2191036.
      View in: PubMed   Mentions: 183     Fields:    Translation:AnimalsCells
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