Christopher P. Gayer, MD, PhD

Title(s)Associate Professor of Clinical Surgery
SchoolKeck School of Medicine of Usc
AddressCHL 4650 W Sunset Blvd
Off Campus
Los Angeles CA 90027
Phone+1 323 361 4974
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    I am interested in bile acid metabolism and how specific bile acid receptors, such as FXR, influence the intestinal epithelial barrier in injury models

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Children with large primary spontaneous pneumothoraxes may benefit from early operative intervention. Pediatr Surg Int. 2022 Mar; 38(3):423-429. Short C, Maselli KM, Mallicote MU, Delaplain P, Gayer C. PMID: 35076755.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. The Pathophysiology of Farnesoid X Receptor (FXR) in the GI Tract: Inflammation, Barrier Function and Innate Immunity. Cells. 2021 11 17; 10(11). Anderson KM, Gayer CP. PMID: 34831429; PMCID: PMC8624027.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    3. Decreased secondary faecal bile acids in children with ulcerative colitis and Clostridioides difficile infection. Aliment Pharmacol Ther. 2021 09; 54(6):792-804. Rotondo-Trivette S, Wang B, Gayer C, Parsana R, Luan Y, Sun F, Michail S. PMID: 34218431; PMCID: PMC8384671.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    4. Primary Adrenal Malignant Rhabdoid Tumor in a 14-Year-Old Female: A Case Report and Literature Review. Int J Surg Pathol. 2022 Apr; 30(2):172-176. Alturkustani M, Schmidt R, Gayer C, Warren M, Navid F, Raca G, Biegel JA, Pawel B, Zhou S. PMID: 34106024.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. EP2 Receptor Blockade Attenuates COX-2 Upregulation During Intestinal Inflammation. Shock. 2020 09; 54(3):394-401. Golden J, Illingworth L, Kavarian P, Escobar O, Delaplain P, Isani M, Wang J, Lim J, Bowling J, Bell B, Gayer CP, Grishin A, Ford HR. PMID: 31490357; PMCID: PMC7051888.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    6. Differences in Serum Alkaline Phosphatase Levels in Infants with Spontaneous Intestinal Perforation versus Necrotizing Enterocolitis with Perforation. Neonatology. 2020; 117(3):349-357. Barseghyan K, Gayer C, Azhibekov T. PMID: 32750698.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    7. The value of prophylactic chest tubes in tracheoesophageal fistula repair. Pediatr Surg Int. 2020 Jun; 36(6):687-696. Nguyen MVL, Delaplain PT, Lim JC, Golden JM, Gayer CP. PMID: 32377785.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    8. Serum bile acids profiling by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and its application on pediatric liver and intestinal diseases. Clin Chem Lab Med. 2020 04 28; 58(5):787-797. Fu X, Xiao Y, Golden J, Niu S, Gayer CP. PMID: 31639099.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    9. Effects of artificially introduced Enterococcus faecalis strains in experimental necrotizing enterocolitis. PLoS One. 2019; 14(11):e0216762. Delaplain PT, Bell BA, Wang J, Isani M, Zhang E, Gayer CP, Grishin AV, Ford HR. PMID: 31675374; PMCID: PMC6824573.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    10. Screening for blunt cerebrovascular injuries in pediatric trauma patients. J Pediatr Surg. 2019 Sep; 54(9):1861-1865. Mallicote MU, Isani MA, Golden J, Ford HR, Upperman JS, Gayer CP. PMID: 31101425.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. Variability in perioperative evaluation and resource utilization in pediatric patients with suspected biliary dyskinesia: A multi-institutional retrospective cohort study. J Pediatr Surg. 2019 Jun; 54(6):1118-1122. Cairo SB, Aranda A, Bartz-Kurycki M, Baxter KJ, Bonasso P, Dassinger M, Deans KJ, Dorey D, Emengo P, Fialkowski E, Gayer C, Gonzales B, Gusman N, Hawkins RB, Herzing K, Huang E, Islam S, Jancelewicz T, Landman MP, Lally KP, Lesher A, Minneci PC, Raval MV, Russell R, Shah S, Slater B, Schoel LJ, Peter SS, Sujka J, Waterhouse J, Rothstein DH, Pediatric Surgery Research Collaborative (PedSRC). PMID: 30885555; PMCID: PMC6822378.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    12. Pilot Study of the Effect of Plant-Based Enteral Nutrition on the Gut Microbiota in Chronically Ill Tube-Fed Children. JPEN J Parenter Enteral Nutr. 2019 09; 43(7):899-911. McClanahan D, Yeh A, Firek B, Zettle S, Rogers M, Cheek R, Nguyen MVL, Gayer CP, Wendell SG, Mullett SJ, Morowitz MJ. PMID: 30644566.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    13. Closing gastroschisis: The good, the bad, and the not-so ugly. J Pediatr Surg. 2019 Jan; 54(1):60-64. Perrone EE, Olson J, Golden JM, Besner GE, Gayer CP, Islam S, Gollin G. PMID: 30482541.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    14. Lactobacillus murinus HF12 colonizes neonatal gut and protects rats from necrotizing enterocolitis. PLoS One. 2018; 13(6):e0196710. Isani M, Bell BA, Delaplain PT, Bowling JD, Golden JM, Elizee M, Illingworth L, Wang J, Gayer CP, Grishin AV, Ford HR. PMID: 29933378; PMCID: PMC6014650.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    15. Ursodeoxycholic acid protects against intestinal barrier breakdown by promoting enterocyte migration via EGFR- and COX-2-dependent mechanisms. Am J Physiol Gastrointest Liver Physiol. 2018 08 01; 315(2):G259-G271. Golden JM, Escobar OH, Nguyen MVL, Mallicote MU, Kavarian P, Frey MR, Gayer CP. PMID: 29672156; PMCID: PMC6139640.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    16. Liquid chromatography-mass spectroscopy in the diagnosis of biliary atresia in children with hyperbilirubinemia. J Surg Res. 2018 08; 228:228-237. Golden J, Zagory JA, Fenlon M, Goodhue CJ, Xiao Y, Fu X, Wang KS, Gayer CP. PMID: 29907216.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    17. Soybean-derived recombinant human epidermal growth factor protects against experimental necrotizing enterocolitis. J Pediatr Surg. 2018 Jun; 53(6):1203-1207. Isani M, Illingworth L, Herman E, Schmidt M, Barron L, Bowling J, Elizee M, Bai I, Gayer C, Grishin A, Erwin CR, Ford HR, Warner BW. PMID: 29636182.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    18. Discussion of: "Hospital admission unnecessary for successful uncomplicated radiographic reduction of pediatric intussusception". Am J Surg. 2017 12; 214(6):1208-1209. Mallicote MU, Isani MA, Roberts AS, Jones NE, Bowen-Jallow KA, Burke RV, Stein JE, Gayer CP. PMID: 29037420.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    19. Hospital admission unnecessary for successful uncomplicated radiographic reduction of pediatric intussusception. Am J Surg. 2017 Dec; 214(6):1203-1207. Mallicote MU, Isani MA, Roberts AS, Jones NE, Bowen-Jallow KA, Burke RV, Stein JE, Gayer CP. PMID: 28969892.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    20. Advances in paediatric gastroenterology. Lancet. 2017 Sep 09; 390(10099):1072-1082. Tam PKH, Chung PHY, St Peter SD, Gayer CP, Ford HR, Tam GCH, Wong KKY, Pakarinen MP, Davenport M. PMID: 28901937.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    21. Routine post-operative esophagram Is not necessary after repair of esophageal atresia. Am J Surg. 2017 Apr; 213(4):640-644. Golden J, Demeter NE, C Lim J, Ford HR, Upperman JS, Gayer CP. PMID: 28057296.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    22. Re-evaluation of liver transaminase cutoff for CT after pediatric blunt abdominal trauma. Pediatr Surg Int. 2017 Mar; 33(3):311-316. Zagory JA, Dossa A, Golden J, Jensen AR, Goodhue CJ, Upperman JS, Gayer CP. PMID: 27878593.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    23. Liver steatosis induced by small bowel resection is prevented by oral vancomycin. Surgery. 2016 12; 160(6):1485-1495. Barron LK, Gayer CP, Roberts A, Golden JM, Aladegbami BG, Guo J, Erwin CR, Warner BW. PMID: 27592213; PMCID: PMC5409838.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    24. Limiting chest computed tomography in the evaluation of pediatric thoracic trauma. J Trauma Acute Care Surg. 2016 08; 81(2):271-7. Golden J, Isani M, Bowling J, Zagory J, Goodhue CJ, Burke RV, Upperman JS, Gayer CP. PMID: 27192472.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    25. Liquid chromatography-mass spectroscopy as a tool in the rapid diagnosis of biliary atresia: a pilot study. J Pediatr Surg. 2016 Jun; 51(6):923-6. Nguyen M, Dossa A, Zagory J, Golden J, Roberts A, Fu X, Wang K, Gayer CP. PMID: 26995515.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    26. An ectopic renin-secreting adrenal corticoadenoma in a child with malignant hypertension. Physiol Rep. 2016 Mar; 4(5). Kaslow AM, Riquier-Brison A, Peti-Peterdi J, Shillingford N, HaDuong J, Venkatramani R, Gayer CP. PMID: 26997629; PMCID: PMC4823597.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    27. Bile acids regulate intestinal cell proliferation by modulating EGFR and FXR signaling. Am J Physiol Gastrointest Liver Physiol. 2016 Jan 15; 310(2):G81-92. Dossa AY, Escobar O, Golden J, Frey MR, Ford HR, Gayer CP. PMID: 26608185; PMCID: PMC4719061.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    28. Admission hematocrit predicts the need for transfusion secondary to hemorrhage in pediatric blunt trauma patients. J Trauma Acute Care Surg. 2015 Oct; 79(4):555-62. Golden J, Dossa A, Goodhue CJ, Upperman JS, Gayer CP. PMID: 26402528.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    29. Images in clinical medicine. Gastric emphysema. N Engl J Med. 2014 May 29; 370(22):e33. Garza U, Gayer C. PMID: 24869741.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    30. Recent developments in Hirschsprung's-associated enterocolitis. Curr Gastroenterol Rep. 2013 Aug; 15(8):340. Pontarelli EM, Ford HR, Gayer CP. PMID: 23857117.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    31. Necrotizing enterocolitis: contemporary management and outcomes. Adv Pediatr. 2013; 60(1):263-79. Papillon S, Castle SL, Gayer CP, Ford HR. PMID: 24007848.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    32. Isolated ruptured appendicitis presenting as pneumatosis intestinalis in a premature neonate. Pediatr Surg Int. 2012 Apr; 28(4):439-41. Kalra VK, Natarajan G, Poulik J, Arora P, Gayer C, Altaany D, Stockman P. PMID: 22186823.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    33. Combined endoscopic and laparoscopic approach to a gastroesophageal tumor. JSLS. 2011 Apr-Jun; 15(2):228-31. Gayer CP, Edelman DA, Curtis B, Laker S, Webber J. PMID: 21902981; PMCID: PMC3148877.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    34. ERK regulates strain-induced migration and proliferation from different subcellular locations. J Cell Biochem. 2010 Mar 01; 109(4):711-25. Gayer CP, Craig DH, Flanigan TL, Reed TD, Cress DE, Basson MD. PMID: 20069571.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    35. Acute lower gastrointestinal bleeding in 1,112 patients admitted to an urban emergency medical center. Surgery. 2009 Oct; 146(4):600-6; discussion 606-7. Gayer C, Chino A, Lucas C, Tokioka S, Yamasaki T, Edelman DA, Sugawa C. PMID: 19789018.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansPHPublic Health
    36. The effects of increased extracellular deformation, pressure, and integrin phosphorylation on fibroblast migration. J Surg Res. 2009 Sep; 156(1):103-9. Flanigan TL, Craig DH, Gayer CP, Basson MD. PMID: 19555977; PMCID: PMC2730954.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    37. The effects of mechanical forces on intestinal physiology and pathology. Cell Signal. 2009 Aug; 21(8):1237-44. Gayer CP, Basson MD. PMID: 19249356; PMCID: PMC2715958.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansCells
    38. Delineating the signals by which repetitive deformation stimulates intestinal epithelial migration across fibronectin. Am J Physiol Gastrointest Liver Physiol. 2009 Apr; 296(4):G876-85. Gayer CP, Chaturvedi LS, Wang S, Alston B, Flanigan TL, Basson MD. PMID: 19179620; PMCID: PMC2670672.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    39. Strain-induced proliferation requires the phosphatidylinositol 3-kinase/AKT/glycogen synthase kinase pathway. J Biol Chem. 2009 Jan 23; 284(4):2001-11. Gayer CP, Chaturvedi LS, Wang S, Craig DH, Flanigan T, Basson MD. PMID: 19047055; PMCID: PMC2629112.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    40. Increased extracellular pressure enhances cancer cell integrin-binding affinity through phosphorylation of beta1-integrin at threonine 788/789. Am J Physiol Cell Physiol. 2009 Jan; 296(1):C193-204. Craig DH, Gayer CP, Schaubert KL, Wei Y, Li J, Laouar Y, Basson MD. PMID: 19005162; PMCID: PMC2637001.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    41. Supraphysiologic extracellular pressure inhibits intestinal epithelial wound healing independently of luminal nutrient flow. Am J Surg. 2008 Nov; 196(5):683-9. Flanigan TL, Owen CR, Gayer C, Basson MD. PMID: 18954600; PMCID: PMC2583260.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    42. Repetitive deformation activates Src-independent FAK-dependent ERK motogenic signals in human Caco-2 intestinal epithelial cells. Am J Physiol Cell Physiol. 2008 Jun; 294(6):C1350-61. Chaturvedi LS, Gayer CP, Marsh HM, Basson MD. PMID: 18400991; PMCID: PMC3971650.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    43. Clinical evaluation and management of caustic injury in the upper gastrointestinal tract in 95 adult patients in an urban medical center. Surg Endosc. 2008 Apr; 22(4):1119-25. Tohda G, Sugawa C, Gayer C, Chino A, McGuire TW, Lucas CE. PMID: 17965918.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
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