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Christopher P. Gayer, MD, PhD

TitleAssistant Professor of Clinical Surgery
InstitutionUniversity of Southern California
DepartmentPediatrics
AddressCHL 4650 W Sunset Blvd
Off Campus
Los Angeles CA 90027
Phone+1 323 361 2104
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    Collapse Overview 
    Collapse Overview
    I am interested in bile acid metabolism and how specific bile acid receptors, such as FXR, influence the intestinal epithelial barrier in injury models


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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Golden JM, Escobar OH, Nguyen MV, Mallicote MU, Kavarian P, Frey MR, Gayer C. Ursodeoxycholic acid protects against intestinal barrier breakdown by promoting enterocyte migration via EGFR- and COX-2-dependent mechanisms. Am J Physiol Gastrointest Liver Physiol. 2018 Apr 19. PMID: 29672156.
      View in: PubMed
    2. Isani M, Illingworth L, Herman E, Schmidt M, Barron L, Bowling J, Elizee M, Bai I, Gayer C, Grishin A, Erwin CR, Ford HR, Warner BW. Soybean-derived recombinant human epidermal growth factor protects against experimental necrotizing enterocolitis. J Pediatr Surg. 2018 Mar 08. PMID: 29636182.
      View in: PubMed
    3. Mallicote MU, Isani MA, Roberts AS, Jones NE, Bowen-Jallow KA, Burke RV, Stein JE, Gayer C. Discussion of: "Hospital admission unnecessary for successful uncomplicated radiographic reduction of pediatric intussusception". Am J Surg. 2017 Dec; 214(6):1208-1209. PMID: 29037420.
      View in: PubMed
    4. Mallicote MU, Isani MA, Roberts AS, Jones NE, Bowen-Jallow KA, Burke RV, Stein JE, Gayer C. Hospital admission unnecessary for successful uncomplicated radiographic reduction of pediatric intussusception. Am J Surg. 2017 Dec; 214(6):1203-1207. PMID: 28969892.
      View in: PubMed
    5. Tam PKH, Chung PHY, St Peter SD, Gayer C, Ford HR, Tam GCH, Wong KKY, Pakarinen MP, Davenport M. Advances in paediatric gastroenterology. Lancet. 2017 Sep 09; 390(10099):1072-1082. PMID: 28901937.
      View in: PubMed
    6. Golden J, Demeter NE, C Lim J, Ford HR, Upperman JS, Gayer C. Routine post-operative esophagram Is not necessary after repair of esophageal atresia. Am J Surg. 2017 Apr; 213(4):640-644. PMID: 28057296.
      View in: PubMed
    7. Zagory JA, Dossa A, Golden J, Jensen AR, Goodhue CJ, Upperman JS, Gayer C. Re-evaluation of liver transaminase cutoff for CT after pediatric blunt abdominal trauma. Pediatr Surg Int. 2017 Mar; 33(3):311-316. PMID: 27878593.
      View in: PubMed
    8. Barron LK, Gayer C, Roberts A, Golden JM, Aladegbami BG, Guo J, Erwin CR, Warner BW. Liver steatosis induced by small bowel resection is prevented by oral vancomycin. Surgery. 2016 12; 160(6):1485-1495. PMID: 27592213.
      View in: PubMed
    9. Golden J, Isani M, Bowling J, Zagory J, Goodhue CJ, Burke RV, Upperman JS, Gayer C. Limiting chest computed tomography in the evaluation of pediatric thoracic trauma. J Trauma Acute Care Surg. 2016 08; 81(2):271-7. PMID: 27192472.
      View in: PubMed
    10. Nguyen M, Dossa A, Zagory J, Golden J, Roberts A, Fu X, Wang K, Gayer C. Liquid chromatography-mass spectroscopy as a tool in the rapid diagnosis of biliary atresia: a pilot study. J Pediatr Surg. 2016 Jun; 51(6):923-6. PMID: 26995515.
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    11. Kaslow AM, Riquier-Brison A, Peti-Peterdi J, Shillingford N, HaDuong J, Venkatramani R, Gayer C. An ectopic renin-secreting adrenal corticoadenoma in a child with malignant hypertension. Physiol Rep. 2016 Mar; 4(5). PMID: 26997629; PMCID: PMC4823597.
    12. Dossa AY, Escobar O, Golden J, Frey MR, Ford HR, Gayer C. Bile acids regulate intestinal cell proliferation by modulating EGFR and FXR signaling. Am J Physiol Gastrointest Liver Physiol. 2016 Jan 15; 310(2):G81-92. PMID: 26608185; PMCID: PMC4719061 [Available on 01/15/17].
    13. Golden J, Dossa A, Goodhue CJ, Upperman JS, Gayer C. Admission hematocrit predicts the need for transfusion secondary to hemorrhage in pediatric blunt trauma patients. J Trauma Acute Care Surg. 2015 Oct; 79(4):555-62. PMID: 26402528.
      View in: PubMed
    14. Garza U, Gayer C. Images in clinical medicine. Gastric emphysema. N Engl J Med. 2014 May 29; 370(22):e33. PMID: 24869741.
      View in: PubMed
    15. Pontarelli EM, Ford HR, Gayer C. Recent developments in Hirschsprung's-associated enterocolitis. Curr Gastroenterol Rep. 2013 Aug; 15(8):340. PMID: 23857117.
      View in: PubMed
    16. Papillon S, Castle SL, Gayer C, Ford HR. Necrotizing enterocolitis: contemporary management and outcomes. Adv Pediatr. 2013; 60(1):263-79. PMID: 24007848.
      View in: PubMed
    17. Kalra VK, Natarajan G, Poulik J, Arora P, Gayer C, Altaany D, Stockman P. Isolated ruptured appendicitis presenting as pneumatosis intestinalis in a premature neonate. Pediatr Surg Int. 2012 Apr; 28(4):439-41. PMID: 22186823.
      View in: PubMed
    18. Gayer C, Edelman DA, Curtis B, Laker S, Webber J. Combined endoscopic and laparoscopic approach to a gastroesophageal tumor. JSLS. 2011 Apr-Jun; 15(2):228-31. PMID: 21902981; PMCID: PMC3148877.
    19. Gayer C, Craig DH, Flanigan TL, Reed TD, Cress DE, Basson MD. ERK regulates strain-induced migration and proliferation from different subcellular locations. J Cell Biochem. 2010 Mar 01; 109(4):711-25. PMID: 20069571.
      View in: PubMed
    20. Gayer C, Chino A, Lucas C, Tokioka S, Yamasaki T, Edelman DA, Sugawa C. Acute lower gastrointestinal bleeding in 1,112 patients admitted to an urban emergency medical center. Surgery. 2009 Oct; 146(4):600-6; discussion 606-7. PMID: 19789018.
      View in: PubMed
    21. Flanigan TL, Craig DH, Gayer C, Basson MD. The effects of increased extracellular deformation, pressure, and integrin phosphorylation on fibroblast migration. J Surg Res. 2009 Sep; 156(1):103-9. PMID: 19555977; PMCID: PMC2730954.
    22. Gayer C, Basson MD. The effects of mechanical forces on intestinal physiology and pathology. Cell Signal. 2009 Aug; 21(8):1237-44. PMID: 19249356; PMCID: PMC2715958.
    23. Gayer C, Chaturvedi LS, Wang S, Alston B, Flanigan TL, Basson MD. Delineating the signals by which repetitive deformation stimulates intestinal epithelial migration across fibronectin. Am J Physiol Gastrointest Liver Physiol. 2009 Apr; 296(4):G876-85. PMID: 19179620; PMCID: PMC2670672.
    24. Gayer C, Chaturvedi LS, Wang S, Craig DH, Flanigan T, Basson MD. Strain-induced proliferation requires the phosphatidylinositol 3-kinase/AKT/glycogen synthase kinase pathway. J Biol Chem. 2009 Jan 23; 284(4):2001-11. PMID: 19047055; PMCID: PMC2629112.
    25. Craig DH, Gayer C, Schaubert KL, Wei Y, Li J, Laouar Y, Basson MD. Increased extracellular pressure enhances cancer cell integrin-binding affinity through phosphorylation of beta1-integrin at threonine 788/789. Am J Physiol Cell Physiol. 2009 Jan; 296(1):C193-204. PMID: 19005162; PMCID: PMC2637001.
    26. Flanigan TL, Owen CR, Gayer C, Basson MD. Supraphysiologic extracellular pressure inhibits intestinal epithelial wound healing independently of luminal nutrient flow. Am J Surg. 2008 Nov; 196(5):683-9. PMID: 18954600; PMCID: PMC2583260.
    27. Chaturvedi LS, Gayer C, Marsh HM, Basson MD. Repetitive deformation activates Src-independent FAK-dependent ERK motogenic signals in human Caco-2 intestinal epithelial cells. Am J Physiol Cell Physiol. 2008 Jun; 294(6):C1350-61. PMID: 18400991; PMCID: PMC3971650.
    28. Tohda G, Sugawa C, Gayer C, Chino A, McGuire TW, Lucas CE. Clinical evaluation and management of caustic injury in the upper gastrointestinal tract in 95 adult patients in an urban medical center. Surg Endosc. 2008 Apr; 22(4):1119-25. PMID: 17965918.
      View in: PubMed