Bodour Salhia, PhD

Title(s)Associate Professor of Translational Genomics
SchoolKeck School of Medicine of Usc
Address1450 Biggy Street
Health Sciences Campus
Los Angeles CA 90089-9601
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    Other Positions
    Title(s)Interim Chair of the Department of Translational Genomics


    Collapse Biography 
    Collapse Education and Training
    University of Toronto, Toronto, CanadaPhD11/2006Cell and Molecular Biology
    University of Toronto, Toronto, CanadaMHSC11/2001Cell and Molecular Biology
    University of Toronto, Toronto, CanadaBS06/1998Biology, Psychology, Spanish

    Collapse Overview 
    Collapse Overview
    Dr. Salhia is a translational genomics scientist with extensive knowledge and expertise in mechanisms that underlie tumorigenesis and tumor biology. She merges cutting edge genomics/epigenomics analyses with cell biological and functional studies towards the investigation of clinically relevant problems in human cancer. During her graduate training, she focused on understanding the molecular and cellular determinants of glioma invasion. Her post-doctoral work focused on the genomics and epigenomics of breast cancer metastasis and multiple myeloma. She also characterized the function of AKT1(E17K) in breast cancer and performed immunophenotypic analysis of breast cancer in North Africa. She has led and continues to lead numerous DNA methylation studies using a plethora of both array and sequencing based technologies to measure whole genome and targeted CpG methylation changes in a variety of cancer types. Dr. Salhia utilizes these data to develop DNA methylation liquid biopsies. Her lab is in the process of validating a DNA methylation liquid biopsy for breast cancer recurrence which would indicate patients with evidence of micrometastatic residual disease that are therefore likely to experience a recurrence. Dr. Salhia’s lab also has research efforts in experimental therapeutics of brain metastasis by utilizing patient-derived xenografts and cell lines to identify novel treatment methods for this dismal disease.

    Dr. Salhia finds it extremely important to connect with the people her research is attempting to serve. She has volunteered with the Arizona Myeloma Network, The Wellness Community, and Susan G. Komen affiliate in Phoenix. She has travelled to Egypt as a US Delegate with the Susan G. Komen for the Cure to raise awareness about breast cancer and she has worked with underserved minorities on the Navajo Nation in Arizona. She served as a Community Outreach Ambassador and was a member of the Board of Directors for the Susan G. Komen for the Cure Arizona between 2012-2016. She has received numerous community awards including a service award by the Arizona Myeloma Network. She was also named one of 20 Faces of Komen in 2012 and 2013 and in June 2014 was the recipient of the Phoenix Business Journal’s Top 40 under 40 award.

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Integrated genomic analysis of survival outliers in glioblastoma. Neuro Oncol. 2017 06 01; 19(6):833-844. Peng S, Dhruv H, Armstrong B, Salhia B, Legendre C, Kiefer J, Parks J, Virk S, Sloan AE, Ostrom QT, Barnholtz-Sloan JS, Tran NL, Berens ME. PMID: 27932423; PMCID: PMC5464466.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    2. Pathway Implications of Aberrant Global Methylation in Adrenocortical Cancer. PLoS One. 2016; 11(3):e0150629. Legendre CR, Demeure MJ, Whitsett TG, Gooden GC, Bussey KJ, Jung S, Waibhav T, Kim S, Salhia B. PMID: 26963385; PMCID: PMC4786116.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    3. Androgen receptor status is highly conserved during tumor progression of breast cancer. BMC Cancer. 2015 Nov 09; 15:872. Grogg A, Trippel M, Pfaltz K, Lädrach C, Droeser RA, Cihoric N, Salhia B, Zweifel M, Tapia C. PMID: 26552477; PMCID: PMC4640208.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    4. Whole-genome bisulfite sequencing of cell-free DNA identifies signature associated with metastatic breast cancer. Clin Epigenetics. 2015; 7:100. Legendre C, Gooden GC, Johnson K, Martinez RA, Liang WS, Salhia B. PMID: 26380585; PMCID: PMC4573288.
      View in: PubMed   Mentions: 43     Fields:    
    5. High tumor budding stratifies breast cancer with metastatic properties. Breast Cancer Res Treat. 2015 Apr; 150(2):363-71. Salhia B, Trippel M, Pfaltz K, Cihoric N, Grogg A, Lädrach C, Zlobec I, Tapia C. PMID: 25779101; PMCID: PMC4368849.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    6. Breast cancer in adolescent and young adult women. Clin Breast Cancer. 2014 Dec; 14(6):390-5. Gewefel H, Salhia B. PMID: 25034440.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    7. Molecular biology of brain metastasis. Int J Mol Sci. 2014 May 28; 15(6):9519-30. Svokos KA, Salhia B, Toms SA. PMID: 24879524; PMCID: PMC4100107.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    8. Small cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4. Nat Genet. 2014 May; 46(5):427-9. Ramos P, Karnezis AN, Craig DW, Sekulic A, Russell ML, Hendricks WP, Corneveaux JJ, Barrett MT, Shumansky K, Yang Y, Shah SP, Prentice LM, Marra MA, Kiefer J, Zismann VL, McEachron TA, Salhia B, Prat J, D'Angelo E, Clarke BA, Pressey JG, Farley JH, Anthony SP, Roden RB, Cunliffe HE, Huntsman DG, Trent JM. PMID: 24658001; PMCID: PMC4332808.
      View in: PubMed   Mentions: 136     Fields:    Translation:HumansCells
    9. Current approaches to the treatment of metastatic brain tumours. Nat Rev Clin Oncol. 2014 Apr; 11(4):203-22. Owonikoko TK, Arbiser J, Zelnak A, Shu HK, Shim H, Robin AM, Kalkanis SN, Whitsett TG, Salhia B, Tran NL, Ryken T, Moore MK, Egan KM, Olson JJ. PMID: 24569448; PMCID: PMC4041037.
      View in: PubMed   Mentions: 119     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    10. Integrated genomic and epigenomic analysis of breast cancer brain metastasis. PLoS One. 2014; 9(1):e85448. Salhia B, Kiefer J, Ross JT, Metapally R, Martinez RA, Johnson KN, DiPerna DM, Paquette KM, Jung S, Nasser S, Wallstrom G, Tembe W, Baker A, Carpten J, Resau J, Ryken T, Sibenaller Z, Petricoin EF, Liotta LA, Ramanathan RK, Berens ME, Tran NL. PMID: 24489661; PMCID: PMC3906004.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    11. In vitro-differentiated neural cell cultures progress towards donor-identical brain tissue. Hum Mol Genet. 2013 Sep 01; 22(17):3534-46. Hjelm BE, Salhia B, Kurdoglu A, Szelinger S, Reiman RA, Sue LI, Beach TG, Huentelman MJ, Craig DW. PMID: 23666530; PMCID: PMC3736871.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    12. DNA methylation in multiple myeloma is weakly associated with gene transcription. PLoS One. 2012; 7(12):e52626. Jung S, Kim S, Gale M, Cherni I, Fonseca R, Carpten J, Salhia B. PMID: 23285118; PMCID: PMC3527579.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    13. Genome and transcriptome sequencing in prospective metastatic triple-negative breast cancer uncovers therapeutic vulnerabilities. Mol Cancer Ther. 2013 Jan; 12(1):104-16. Craig DW, O'Shaughnessy JA, Kiefer JA, Aldrich J, Sinari S, Moses TM, Wong S, Dinh J, Christoforides A, Blum JL, Aitelli CL, Osborne CR, Izatt T, Kurdoglu A, Baker A, Koeman J, Barbacioru C, Sakarya O, De La Vega FM, Siddiqui A, Hoang L, Billings PR, Salhia B, Tolcher AW, Trent JM, Mousses S, Von Hoff D, Carpten JD. PMID: 23171949.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansCells
    14. Differential effects of AKT1(p.E17K) expression on human mammary luminal epithelial and myoepithelial cells. Hum Mutat. 2012 Aug; 33(8):1216-27. Salhia B, Van Cott C, Tegeler T, Polpitiya A, Duquette RA, Gale M, Hostteter G, Petritis K, Carpten J. PMID: 22505016.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    15. Molecular subtype analysis determines the association of advanced breast cancer in Egypt with favorable biology. BMC Womens Health. 2011 Sep 30; 11:44. Salhia B, Tapia C, Ishak EA, Gaber S, Berghuis B, Hussain KH, DuQuette RA, Resau J, Carpten J. PMID: 21961708; PMCID: PMC3204283.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    16. DNA methylation analysis determines the high frequency of genic hypomethylation and low frequency of hypermethylation events in plasma cell tumors. Cancer Res. 2010 Sep 01; 70(17):6934-44. Salhia B, Baker A, Ahmann G, Auclair D, Fonseca R, Carpten J. PMID: 20736376.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    17. The Guanine Nucleotide Exchange Factor SWAP-70 Modulates the Migration and Invasiveness of Human Malignant Glioma Cells. Transl Oncol. 2009 Dec; 2(4):300-9. Seol HJ, Smith CA, Salhia B, Rutka JT. PMID: 19956392; PMCID: PMC2781081.
      View in: PubMed   Mentions: 11  
    18. The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma. Am J Pathol. 2008 Dec; 173(6):1828-38. Salhia B, Tran NL, Chan A, Wolf A, Nakada M, Rutka F, Ennis M, McDonough WS, Berens ME, Symons M, Rutka JT. PMID: 19008376; PMCID: PMC2626393.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansAnimalsCells
    19. The role of fascin in the migration and invasiveness of malignant glioma cells. Neoplasia. 2008 Feb; 10(2):149-59. Hwang JH, Smith CA, Salhia B, Rutka JT. PMID: 18283337; PMCID: PMC2244690.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    20. Role of myosin II activity and the regulation of myosin light chain phosphorylation in astrocytomas. Cell Motil Cytoskeleton. 2008 Jan; 65(1):12-24. Salhia B, Hwang JH, Smith CA, Nakada M, Rutka F, Symons M, Rutka JT. PMID: 17896341.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    21. Current concepts in the molecular genetics of pediatric brain tumors: implications for emerging therapies. Childs Nerv Syst. 2006 Nov; 22(11):1379-94. Tamber MS, Bansal K, Liang ML, Mainprize TG, Salhia B, Northcott P, Taylor M, Rutka JT. PMID: 16951964.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    22. Molecular pathways triggering glioma cell invasion. Expert Rev Mol Diagn. 2006 Jul; 6(4):613-26. Salhia B, Tran NL, Symons M, Winkles JA, Rutka JT, Berens ME. PMID: 16824034.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    23. Inhibition of Rho-kinase affects astrocytoma morphology, motility, and invasion through activation of Rac1. Cancer Res. 2005 Oct 01; 65(19):8792-800. Salhia B, Rutten F, Nakada M, Beaudry C, Berens M, Kwan A, Rutka JT. PMID: 16204049.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansCells
    24. Analysis of mammalian septin expression in human malignant brain tumors. Neoplasia. 2004 Mar-Apr; 6(2):168-78. Kim DS, Hubbard SL, Peraud A, Salhia B, Sakai K, Rutka JT. PMID: 15140406; PMCID: PMC1502092.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    25. Imaging of murine brain tumors using a 1.5 Tesla clinical MRI system. Can J Neurol Sci. 2003 Nov; 30(4):326-32. van Furth WR, Laughlin S, Taylor MD, Salhia B, Mainprize T, Henkelman M, Cusimano MD, Ackerley C, Rutka JT. PMID: 14672264.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    26. The treatment of malignant meningioma with verotoxin. Neoplasia. 2002 Jul-Aug; 4(4):304-11. Salhia B, Rutka JT, Lingwood C, Nutikka A, Van Furth WR. PMID: 12082546; PMCID: PMC1531702.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    27. Evaluation of proliferative index and cell cycle protein expression in choroid plexus tumors in children. Acta Neuropathol. 2002 Jan; 103(1):1-10. Carlotti CG, Salhia B, Weitzman S, Greenberg M, Dirks PB, Mason W, Becker LE, Rutka JT. PMID: 11837741.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    28. Hyaluronate receptors mediating glioma cell migration and proliferation. J Neurooncol. 2001 Jun; 53(2):115-27. Akiyama Y, Jung S, Salhia B, Lee S, Hubbard S, Taylor M, Mainprize T, Akaishi K, van Furth W, Rutka JT. PMID: 11716065.
      View in: PubMed   Mentions: 47     Fields:    Translation:Cells
    29. Expression of vascular endothelial growth factor by reactive astrocytes and associated neoangiogenesis. Brain Res. 2000 Nov 10; 883(1):87-97. Salhia B, Angelov L, Roncari L, Wu X, Shannon P, Guha A. PMID: 11063991.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    30. Adenoviral vector-mediated gene transfer: timing of wild-type p53 gene expression in vivo and effect of tumor transduction on survival in a rat glioma brachytherapy model. J Neurooncol. 2000 Aug; 49(1):27-39. Bampoe J, Glen J, Hubbard SL, Salhia B, Shannon P, Rutka J, Bernstein M. PMID: 11131984.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    31. Inhibition of angiogenesis by blocking activation of the vascular endothelial growth factor receptor 2 leads to decreased growth of neurogenic sarcomas. Cancer Res. 1999 Nov 01; 59(21):5536-41. Angelov L, Salhia B, Roncari L, McMahon G, Guha A. PMID: 10554031.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    32. Elective neurosurgical office consultations: how well are patients informed? Can J Public Health. 1998 Jul-Aug; 89(4):280-3. Bampoe J, Salhia B, Micallef J, Glen J, Bernstein M. PMID: 9735526; PMCID: PMC6990200.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
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    NIH Funding Acknowledgment: Important - All publications resulting from the utilization of SC CTSI resources are required to credit the SC CTSI grant by including the NIH funding acknowledgment and must comply with the NIH Public Access Policy.

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