Bingfei Yu

Title(s)Assistant Professor of Molecular Microbiology and Immunology
SchoolKeck School of Medicine of Usc
Address2011 Zonal Ave.
Health Sciences Campus
Los Angeles CA 90033
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    University of California, San DiegoPh.D.06/2018Immunology

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    The Yu Lab at USC is devoted to decoding intercellular immune recognition and intracellular molecular programming to advance immunotherapies for cancer, autoimmunity and infectious diseases.

    We employ single-cell genomics, synthetic biology, and systems immunology to study the fundamental principles of how immune cells integrate antigen specificity and environmental cues to mount effective immune responses.

    We ask
    (1) How do immune cells "see" foreign antigens to evoke immune responses?
    (2) How do immune cells "talk" to other cells to control their fate decisions?
    (3) How can we "write" molecular circuits to modify immune cell behavior?

    Lab website: https://bingfeiyulab.org/
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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. DNA architectural protein CTCF facilitates subset-specific chromatin interactions to limit the formation of memory CD8+ T cells. Immunity. 2023 05 09; 56(5):959-978.e10. Quon S, Yu B, Russ BE, Tsyganov K, Nguyen H, Toma C, Heeg M, Hocker JD, Milner JJ, Crotty S, Pipkin ME, Turner SJ, Goldrath AW. PMID: 37040762; PMCID: PMC10265493.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    2. Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells. bioRxiv. 2023 Mar 22. Tsuchida CA, Brandes N, Bueno R, Trinidad M, Mazumder T, Yu B, Hwang B, Chang C, Liu J, Sun Y, Hopkins CR, Parker KR, Qi Y, Satpathy AT, Stadtmauer EA, Cate JHD, Eyquem J, Fraietta JA, June CH, Chang HY, Ye CJ, Doudna JA. PMID: 36993359; PMCID: PMC10055432.
      View in: PubMed   Mentions:
    3. Engineered cell entry links receptor biology with single-cell genomics. Cell. 2022 12 22; 185(26):4904-4920.e22. Yu B, Shi Q, Belk JA, Yost KE, Parker KR, Li R, Liu BB, Huang H, Lingwood D, Greenleaf WJ, Davis MM, Satpathy AT, Chang HY. PMID: 36516854; PMCID: PMC9789208.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    4. A microRNA expression and regulatory element activity atlas of the mouse immune system. Nat Immunol. 2021 07; 22(7):914-927. Rose SA, Wroblewska A, Dhainaut M, Yoshida H, Shaffer JM, Bektesevic A, Ben-Zvi B, Rhoads A, Kim EY, Yu B, Lavin Y, Merad M, Buenrostro JD, Brown BD, Immunological Genome Consortium. PMID: 34099919; PMCID: PMC8480231.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    5. Bromodomain protein BRD4 directs and sustains CD8 T cell differentiation during infection. J Exp Med. 2021 08 02; 218(8). Milner JJ, Toma C, Quon S, Omilusik K, Scharping NE, Dey A, Reina-Campos M, Nguyen H, Getzler AJ, Diao H, Yu B, Delpoux A, Yoshida TM, Li D, Qi J, Vincek A, Hedrick SM, Egawa T, Zhou MM, Crotty S, Ozato K, Pipkin ME, Goldrath AW. PMID: 34037670; PMCID: PMC8160575.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    6. B cell-specific XIST complex enforces X-inactivation and restrains atypical B cells. Cell. 2021 04 01; 184(7):1790-1803.e17. Yu B, Qi Y, Li R, Shi Q, Satpathy AT, Chang HY. PMID: 33735607; PMCID: PMC9196326.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    7. Heterogeneity and clonal relationships of adaptive immune cells in ulcerative colitis revealed by single-cell analyses. Sci Immunol. 2020 08 21; 5(50). Boland BS, He Z, Tsai MS, Olvera JG, Omilusik KD, Duong HG, Kim ES, Limary AE, Jin W, Milner JJ, Yu B, Patel SA, Louis TL, Tysl T, Kurd NS, Bortnick A, Quezada LK, Kanbar JN, Miralles A, Huylebroeck D, Valasek MA, Dulai PS, Singh S, Lu LF, Bui JD, Murre C, Sandborn WJ, Goldrath AW, Yeo GW, Chang JT. PMID: 32826341; PMCID: PMC7733868.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    8. Bcl-6 is the nexus transcription factor of T follicular helper cells via repressor-of-repressor circuits. Nat Immunol. 2020 07; 21(7):777-789. Choi J, Diao H, Faliti CE, Truong J, Rossi M, Bélanger S, Yu B, Goldrath AW, Pipkin ME, Crotty S. PMID: 32572238; PMCID: PMC7449381.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    9. T-bet Transcription Factor Promotes Antibody-Secreting Cell Differentiation by Limiting the Inflammatory Effects of IFN-γ on B Cells. Immunity. 2019 05 21; 50(5):1172-1187.e7. Stone SL, Peel JN, Scharer CD, Risley CA, Chisolm DA, Schultz MD, Yu B, Ballesteros-Tato A, Wojciechowski W, Mousseau B, Misra RS, Hanidu A, Jiang H, Qi Z, Boss JM, Randall TD, Brodeur SR, Goldrath AW, Weinmann AS, Rosenberg AF, Lund FE. PMID: 31076359; PMCID: PMC6929688.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    10. The cis-Regulatory Atlas of the Mouse Immune System. Cell. 2019 02 07; 176(4):897-912.e20. Yoshida H, Lareau CA, Ramirez RN, Rose SA, Maier B, Wroblewska A, Desland F, Chudnovskiy A, Mortha A, Dominguez C, Tellier J, Kim E, Dwyer D, Shinton S, Nabekura T, Qi Y, Yu B, Robinette M, Kim KW, Wagers A, Rhoads A, Nutt SL, Brown BD, Mostafavi S, Buenrostro JD, Benoist C, Immunological Genome Project. PMID: 30686579; PMCID: PMC6785993.
      View in: PubMed   Mentions: 173     Fields:    Translation:AnimalsCells
    11. The Transcription Factor Runx3 Establishes Chromatin Accessibility of cis-Regulatory Landscapes that Drive Memory Cytotoxic T Lymphocyte Formation. Immunity. 2018 04 17; 48(4):659-674.e6. Wang D, Diao H, Getzler AJ, Rogal W, Frederick MA, Milner J, Yu B, Crotty S, Goldrath AW, Pipkin ME. PMID: 29669249; PMCID: PMC6750808.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    12. Sustained Id2 regulation of E proteins is required for terminal differentiation of effector CD8+ T cells. J Exp Med. 2018 03 05; 215(3):773-783. Omilusik KD, Nadjsombati MS, Shaw LA, Yu B, Milner JJ, Goldrath AW. PMID: 29440362; PMCID: PMC5839762.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    13. Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours. Nature. 2017 12 14; 552(7684):253-257. Milner JJ, Toma C, Yu B, Zhang K, Omilusik K, Phan AT, Wang D, Getzler AJ, Nguyen T, Crotty S, Wang W, Pipkin ME, Goldrath AW. PMID: 29211713; PMCID: PMC5747964.
      View in: PubMed   Mentions: 305     Fields:    Translation:HumansAnimalsCells
    14. Apolipoprotein O expression in mouse liver enhances hepatic lipid accumulation by impairing mitochondrial function. Biochem Biophys Res Commun. 2017 09 09; 491(1):8-14. Tian F, Wu CL, Yu BL, Liu L, Hu JR. PMID: 28647361.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    15. Epigenetic landscapes reveal transcription factors that regulate CD8+ T cell differentiation. Nat Immunol. 2017 05; 18(5):573-582. Yu B, Zhang K, Milner JJ, Toma C, Chen R, Scott-Browne JP, Pereira RM, Crotty S, Chang JT, Pipkin ME, Wang W, Goldrath AW. PMID: 28288100; PMCID: PMC5395420.
      View in: PubMed   Mentions: 113     Fields:    Translation:AnimalsCells
    16. Early transcriptional and epigenetic regulation of CD8+ T cell differentiation revealed by single-cell RNA sequencing. Nat Immunol. 2017 04; 18(4):422-432. Kakaradov B, Arsenio J, Widjaja CE, He Z, Aigner S, Metz PJ, Yu B, Wehrens EJ, Lopez J, Kim SH, Zuniga EI, Goldrath AW, Chang JT, Yeo GW. PMID: 28218746; PMCID: PMC5360497.
      View in: PubMed   Mentions: 111     Fields:    Translation:AnimalsCells
    17. Transcriptional repressor ZEB2 promotes terminal differentiation of CD8+ effector and memory T cell populations during infection. J Exp Med. 2015 Nov 16; 212(12):2027-39. Omilusik KD, Best JA, Yu B, Goossens S, Weidemann A, Nguyen JV, Seuntjens E, Stryjewska A, Zweier C, Roychoudhuri R, Gattinoni L, Bird LM, Higashi Y, Kondoh H, Huylebroeck D, Haigh J, Goldrath AW. PMID: 26503445; PMCID: PMC4647262.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansAnimalsCells
    18. Signal-induced Brd4 release from chromatin is essential for its role transition from chromatin targeting to transcriptional regulation. Nucleic Acids Res. 2011 Dec; 39(22):9592-604. Ai N, Hu X, Ding F, Yu B, Wang H, Lu X, Zhang K, Li Y, Han A, Lin W, Liu R, Chen R. PMID: 21890894; PMCID: PMC3239188.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
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