Simon Melov

Title(s)Professor
SchoolSchool of Gerontology
Address3715 McClintock Avenue, GER 102
University Park Campus
Los Angeles CA 90089
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Judith Campisi (1948-2024). Nat Cell Biol. 2024 Apr 08. Melov S, Schilling B, Ellerby LM, Kapahi P. PMID: 38589533.
      View in: PubMed   Mentions:
    2. Aging impairs the osteocytic regulation of collagen integrity and bone quality. Bone Res. 2024 Feb 26; 12(1):13. Schurman CA, Kaya S, Dole N, Luna NMM, Castillo N, Potter R, Rose JP, Bons J, King CD, Burton JB, Schilling B, Melov S, Tang S, Schaible E, Alliston T. PMID: 38409111; PMCID: PMC10897167.
      View in: PubMed   Mentions: Translation:HumansAnimalsCells
    3. Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence. Aging Cell. 2023 Dec 07; e14060. Mahoney SA, Venkatasubramanian R, Darrah MA, Ludwig KR, VanDongen NS, Greenberg NT, Longtine AG, Hutton DA, Brunt VE, Campisi J, Melov S, Seals DR, Rossman MJ, Clayton ZS. PMID: 38062873.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    4. Senescent and disease-associated microglia are modifiable features of aged brain white matter. Res Sq. 2023 Oct 30. Carver CM, Gomez PT, Rodriguez SL, Kachergus JM, Liu Y, Shi J, Tran T, Wang L, Melov S, Thompson EA, Schafer MJ. PMID: 37961365; PMCID: PMC10635389.
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    5. Role of the Senescence-Associated Factor Dipeptidyl Peptidase 4 in the Pathogenesis of SARS-CoV-2 Infection. Aging Dis. 2023 Sep 03. Deinhardt-Emmer S, Deshpande S, Kitazawa K, Herman AB, Bons J, Rose JP, Kumar PA, Anerillas C, Neri F, Ciotlos S, Perez K, Köse-Vogel N, Häder A, Abdelmohsen K, Löffler B, Gorospe M, Desprez PY, Melov S, Furman D, Schilling B, Campisi J. PMID: 37728586.
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    6. Cellular Senescence Contributes to Large Elastic Artery Stiffening and Endothelial Dysfunction With Aging: Amelioration With Senolytic Treatment. Hypertension. 2023 10; 80(10):2072-2087. Clayton ZS, Rossman MJ, Mahoney SA, Venkatasubramanian R, Maurer GS, Hutton DA, VanDongen NS, Greenberg NT, Longtine AG, Ludwig KR, Brunt VE, LaRocca TJ, Campisi J, Melov S, Seals DR. PMID: 37593877; PMCID: PMC10530538.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    7. Organ Mapping Antibody Panels: a community resource for standardized multiplexed tissue imaging. Nat Methods. 2023 08; 20(8):1174-1178. Quardokus EM, Saunders DC, McDonough E, Hickey JW, Werlein C, Surrette C, Rajbhandari P, Casals AM, Tian H, Lowery L, Neumann EK, Björklund F, Neelakantan TV, Croteau J, Wiblin AE, Fisher J, Livengood AJ, Dowell KG, Silverstein JC, Spraggins JM, Pryhuber GS, Deutsch G, Ginty F, Nolan GP, Melov S, Jonigk D, Caldwell MA, Vlachos IS, Muller W, Gehlenborg N, Stockwell BR, Lundberg E, Snyder MP, Germain RN, Camarillo JM, Kelleher NL, Börner K, Radtke AJ. PMID: 37468619; PMCID: PMC10406602.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    8. The D3 -creatine dilution method non-invasively measures muscle mass in mice. Aging Cell. 2023 08; 22(8):e13897. Wimer L, Goncharova E, Galkina S, Nyangau E, Shankaran M, Davis A, Prado L, Munoz MC, Epstein S, Patterson C, Shaum N, Hellerstein M, Evans W, Melov S. PMID: 37272263; PMCID: PMC10410001.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    9. Antiretroviral protease inhibitors induce features of cellular senescence that are reversible upon drug removal. Aging Cell. 2023 01; 22(1):e13750. Kuehnemann C, Hughes JB, Desprez PY, Melov S, Wiley CD, Campisi J. PMID: 36539941; PMCID: PMC9835573.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    10. Single nuclei profiling identifies cell specific markers of skeletal muscle aging, frailty, and senescence. Aging (Albany NY). 2022 12 13; 14(23):9393-9422. Perez K, Ciotlos S, McGirr J, Limbad C, Doi R, Nederveen JP, Nilsson MI, Winer DA, Evans W, Tarnopolsky M, Campisi J, Melov S. PMID: 36516485; PMCID: PMC9792217.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    11. Dietary restriction and the transcription factor clock delay eye aging to extend lifespan in Drosophila Melanogaster. Nat Commun. 2022 06 07; 13(1):3156. Hodge BA, Meyerhof GT, Katewa SD, Lian T, Lau C, Bar S, Leung NY, Li M, Li-Kroeger D, Melov S, Schilling B, Montell C, Kapahi P. PMID: 35672419; PMCID: PMC9174495.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    12. Senolysis induced by 25-hydroxycholesterol targets CRYAB in multiple cell types. iScience. 2022 Feb 18; 25(2):103848. Limbad C, Doi R, McGirr J, Ciotlos S, Perez K, Clayton ZS, Daya R, Seals DR, Campisi J, Melov S. PMID: 35198901; PMCID: PMC8851282.
      View in: PubMed   Mentions: 13  
    13. Accelerated aging of the brain transcriptome by the common chemotherapeutic doxorubicin. Exp Gerontol. 2021 09; 152:111451. Cavalier AN, Clayton ZS, Hutton DA, Wahl D, Lark DS, Reisz JA, Melov S, Campisi J, Seals DR, LaRocca TJ. PMID: 34147619; PMCID: PMC8319121.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    14. Apigenin restores endothelial function by ameliorating oxidative stress, reverses aortic stiffening, and mitigates vascular inflammation with aging. Am J Physiol Heart Circ Physiol. 2021 07 01; 321(1):H185-H196. Clayton ZS, Hutton DA, Brunt VE, VanDongen NS, Ziemba BP, Casso AG, Greenberg NT, Mercer AN, Rossman MJ, Campisi J, Melov S, Seals DR. PMID: 34114892; PMCID: PMC8321807.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    15. Tumor Necrosis Factor Alpha-Mediated Inflammation and Remodeling of the Extracellular Matrix Underlies Aortic Stiffening Induced by the Common Chemotherapeutic Agent Doxorubicin. Hypertension. 2021 05 05; 77(5):1581-1590. Clayton ZS, Brunt VE, Hutton DA, Casso AG, Ziemba BP, Melov S, Campisi J, Seals DR. PMID: 33719511; PMCID: PMC8035245.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    16. Longitudinal Functional Study of Murine Aging: A Resource for Future Study Designs. JBMR Plus. 2021 Mar; 5(3):e10466. Evans DS, O'Leary MN, Murphy R, Schmidt M, Koenig K, Presley M, Garrett B, Kim HN, Han L, Academia EC, Laye MJ, Edgar D, Zambataro CA, Barhydt T, Dewey CM, Mayfield J, Wilson J, Alavez S, Lucanic M, Kennedy BK, Almeida M, Andersen JK, Kapahi P, Lithgow GJ, Melov S. PMID: 33778327; PMCID: PMC7990142.
      View in: PubMed   Mentions: 6  
    17. Superoxide produced by mitochondrial site IQ inactivates cardiac succinate dehydrogenase and induces hepatic steatosis in Sod2 knockout mice. Free Radic Biol Med. 2021 02 20; 164:223-232. Wong HS, Mezera V, Dighe P, Melov S, Gerencser AA, Sweis RF, Pliushchev M, Wang Z, Esbenshade T, McKibben B, Riedmaier S, Brand MD. PMID: 33421588.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    18. From discoveries in ageing research to therapeutics for healthy ageing. Nature. 2019 07; 571(7764):183-192. Campisi J, Kapahi P, Lithgow GJ, Melov S, Newman JC, Verdin E. PMID: 31292558; PMCID: PMC7205183.
      View in: PubMed   Mentions: 375     Fields:    Translation:HumansCells
    19. mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance. Cell Stem Cell. 2017 Dec 07; 21(6):806-818.e5. Haller S, Kapuria S, Riley RR, O'Leary MN, Schreiber KH, Andersen JK, Melov S, Que J, Rando TA, Rock J, Kennedy BK, Rodgers JT, Jasper H. PMID: 29220665; PMCID: PMC5823264.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    20. Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. Nat Commun. 2017 11 07; 8(1):1414. Zillikens MC, Demissie S, Hsu YH, Yerges-Armstrong LM, Chou WC, Stolk L, Livshits G, Broer L, Johnson T, Koller DL, Kutalik Z, Luan J, Malkin I, Ried JS, Smith AV, Thorleifsson G, Vandenput L, Hua Zhao J, Zhang W, Aghdassi A, Åkesson K, Amin N, Baier LJ, Barroso I, Bennett DA, Bertram L, Biffar R, Bochud M, Boehnke M, Borecki IB, Buchman AS, Byberg L, Campbell H, Campos Obanda N, Cauley JA, Cawthon PM, Cederberg H, Chen Z, Cho NH, Jin Choi H, Claussnitzer M, Collins F, Cummings SR, De Jager PL, Demuth I, Dhonukshe-Rutten RAM, Diatchenko L, Eiriksdottir G, Enneman AW, Erdos M, Eriksson JG, Eriksson J, Estrada K, Evans DS, Feitosa MF, Fu M, Garcia M, Gieger C, Girke T, Glazer NL, Grallert H, Grewal J, Han BG, Hanson RL, Hayward C, Hofman A, Hoffman EP, Homuth G, Hsueh WC, Hubal MJ, Hubbard A, Huffman KM, Husted LB, Illig T, Ingelsson E, Ittermann T, Jansson JO, Jordan JM, Jula A, Karlsson M, Khaw KT, Kilpeläinen TO, Klopp N, Kloth JSL, Koistinen HA, Kraus WE, Kritchevsky S, Kuulasmaa T, Kuusisto J, Laakso M, Lahti J, Lang T, Langdahl BL, Launer LJ, Lee JY, Lerch MM, Lewis JR, Lind L, Lindgren C, Liu Y, Liu T, Liu Y, Ljunggren Ö, Lorentzon M, Luben RN, Maixner W, McGuigan FE, Medina-Gomez C, Meitinger T, Melhus H, Mellström D, Melov S, Michaëlsson K, Mitchell BD, Morris AP, Mosekilde L, Newman A, Nielson CM, O'Connell JR, Oostra BA, Orwoll ES, Palotie A, Parker SCJ, Peacock M, Perola M, Peters A, Polasek O, Prince RL, Räikkönen K, Ralston SH, Ripatti S, Robbins JA, Rotter JI, Rudan I, Salomaa V, Satterfield S, Schadt EE, Schipf S, Scott L, Sehmi J, Shen J, Soo Shin C, Sigurdsson G, Smith S, Soranzo N, Stancáková A, Steinhagen-Thiessen E, Streeten EA, Styrkarsdottir U, Swart KMA, Tan ST, Tarnopolsky MA, Thompson P, Thomson CA, Thorsteinsdottir U, Tikkanen E, Tranah GJ, Tuomilehto J, van Schoor NM, Verma A, Vollenweider P, Völzke H, Wactawski-Wende J, Walker M, Weedon MN, Welch R, Wichmann HE, Widen E, Williams FMK, Wilson JF, Wright NC, Xie W, Yu L, Zhou Y, Chambers JC, Döring A, van Duijn CM, Econs MJ, Gudnason V, Kooner JS, Psaty BM, Spector TD, Stefansson K, Rivadeneira F, Uitterlinden AG, Wareham NJ, Ossowski V, Waterworth D, Loos RJF, Karasik D, Harris TB, Ohlsson C, Kiel DP. PMID: 29116125; PMCID: PMC5676783.
      View in: PubMed   Mentions: 3     Fields:    
    21. Unmasking Transcriptional Heterogeneity in Senescent Cells. Curr Biol. 2017 Sep 11; 27(17):2652-2660.e4. Hernandez-Segura A, de Jong TV, Melov S, Guryev V, Campisi J, Demaria M. PMID: 28844647; PMCID: PMC5788810.
      View in: PubMed   Mentions: 334     Fields:    Translation:HumansAnimalsCells
    22. Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. Nat Commun. 2017 07 19; 8(1):80. Zillikens MC, Demissie S, Hsu YH, Yerges-Armstrong LM, Chou WC, Stolk L, Livshits G, Broer L, Johnson T, Koller DL, Kutalik Z, Luan J, Malkin I, Ried JS, Smith AV, Thorleifsson G, Vandenput L, Hua Zhao J, Zhang W, Aghdassi A, Åkesson K, Amin N, Baier LJ, Barroso I, Bennett DA, Bertram L, Biffar R, Bochud M, Boehnke M, Borecki IB, Buchman AS, Byberg L, Campbell H, Campos Obanda N, Cauley JA, Cawthon PM, Cederberg H, Chen Z, Cho NH, Jin Choi H, Claussnitzer M, Collins F, Cummings SR, De Jager PL, Demuth I, Dhonukshe-Rutten RAM, Diatchenko L, Eiriksdottir G, Enneman AW, Erdos M, Eriksson JG, Eriksson J, Estrada K, Evans DS, Feitosa MF, Fu M, Garcia M, Gieger C, Girke T, Glazer NL, Grallert H, Grewal J, Han BG, Hanson RL, Hayward C, Hofman A, Hoffman EP, Homuth G, Hsueh WC, Hubal MJ, Hubbard A, Huffman KM, Husted LB, Illig T, Ingelsson E, Ittermann T, Jansson JO, Jordan JM, Jula A, Karlsson M, Khaw KT, Kilpeläinen TO, Klopp N, Kloth JSL, Koistinen HA, Kraus WE, Kritchevsky S, Kuulasmaa T, Kuusisto J, Laakso M, Lahti J, Lang T, Langdahl BL, Launer LJ, Lee JY, Lerch MM, Lewis JR, Lind L, Lindgren C, Liu Y, Liu T, Liu Y, Ljunggren Ö, Lorentzon M, Luben RN, Maixner W, McGuigan FE, Medina-Gomez C, Meitinger T, Melhus H, Mellström D, Melov S, Michaëlsson K, Mitchell BD, Morris AP, Mosekilde L, Newman A, Nielson CM, O'Connell JR, Oostra BA, Orwoll ES, Palotie A, Parker SCJ, Peacock M, Perola M, Peters A, Polasek O, Prince RL, Räikkönen K, Ralston SH, Ripatti S, Robbins JA, Rotter JI, Rudan I, Salomaa V, Satterfield S, Schadt EE, Schipf S, Scott L, Sehmi J, Shen J, Soo Shin C, Sigurdsson G, Smith S, Soranzo N, Stancáková A, Steinhagen-Thiessen E, Streeten EA, Styrkarsdottir U, Swart KMA, Tan ST, Tarnopolsky MA, Thompson P, Thomson CA, Thorsteinsdottir U, Tikkanen E, Tranah GJ, Tuomilehto J, van Schoor NM, Verma A, Vollenweider P, Völzke H, Wactawski-Wende J, Walker M, Weedon MN, Welch R, Wichmann HE, Widen E, Williams FMK, Wilson JF, Wright NC, Xie W, Yu L, Zhou Y, Chambers JC, Döring A, van Duijn CM, Econs MJ, Gudnason V, Kooner JS, Psaty BM, Spector TD, Stefansson K, Rivadeneira F, Uitterlinden AG, Wareham NJ, Ossowski V, Waterworth D, Loos RJF, Karasik D, Harris TB, Ohlsson C, Kiel DP. PMID: 28724990; PMCID: PMC5517526.
      View in: PubMed   Mentions: 86     Fields:    Translation:Humans
    23. Analysis of individual cells identifies cell-to-cell variability following induction of cellular senescence. Aging Cell. 2017 10; 16(5):1043-1050. Wiley CD, Flynn JM, Morrissey C, Lebofsky R, Shuga J, Dong X, Unger MA, Vijg J, Melov S, Campisi J. PMID: 28699239; PMCID: PMC5595671.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansCells
    24. Response by Simpson et al to Letter Regarding Article, "Adrenergic Receptors in Individual Ventricular Myocytes: the Beta-1 and Alpha-1B Are in All Cells, the Alpha-1A Is in a Subpopulation, and the Beta-2 and Beta-3 Are Mostly Absent". Circ Res. 2017 06 09; 120(12):e56-e57. Simpson PC, Myagmar BE, Swigart PM, Melov S, Baker AJ. PMID: 28596177; PMCID: PMC5501172.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    25. Long-term calorie restriction in humans is not associated with indices of delayed immunologic aging: A descriptive study. Nutr Healthy Aging. 2017 Mar 31; 4(2):147-156. Tomiyama AJ, Milush JM, Lin J, Flynn JM, Kapahi P, Verdin E, Sinclair E, Melov S, Epel ES. PMID: 28447069; PMCID: PMC5389018.
      View in: PubMed   Mentions: 6  
    26. Adrenergic Receptors in Individual Ventricular Myocytes: The Beta-1 and Alpha-1B Are in All Cells, the Alpha-1A Is in a Subpopulation, and the Beta-2 and Beta-3 Are Mostly Absent. Circ Res. 2017 Mar 31; 120(7):1103-1115. Myagmar BE, Flynn JM, Cowley PM, Swigart PM, Montgomery MD, Thai K, Nair D, Gupta R, Deng DX, Hosoda C, Melov S, Baker AJ, Simpson PC. PMID: 28219977; PMCID: PMC5376223.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    27. Expression patterns of cardiac aging in Drosophila. Aging Cell. 2017 Feb; 16(1):82-92. Cannon L, Zambon AC, Cammarato A, Zhang Z, Vogler G, Munoz M, Taylor E, Cartry J, Bernstein SI, Melov S, Bodmer R. PMID: 28090760; PMCID: PMC5242310.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    28. Ribosomal Proteins Rpl22 and Rpl22l1 Control Morphogenesis by Regulating Pre-mRNA Splicing. Cell Rep. 2017 01 10; 18(2):545-556. Zhang Y, O'Leary MN, Peri S, Wang M, Zha J, Melov S, Kappes DJ, Feng Q, Rhodes J, Amieux PS, Morris DR, Kennedy BK, Wiest DL. PMID: 28076796; PMCID: PMC5234864.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    29. Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse. Cancer Discov. 2017 02; 7(2):165-176. Demaria M, O'Leary MN, Chang J, Shao L, Liu S, Alimirah F, Koenig K, Le C, Mitin N, Deal AM, Alston S, Academia EC, Kilmarx S, Valdovinos A, Wang B, de Bruin A, Kennedy BK, Melov S, Zhou D, Sharpless NE, Muss H, Campisi J. PMID: 27979832; PMCID: PMC5296251.
      View in: PubMed   Mentions: 537     Fields:    Translation:HumansAnimals
    30. Uncovering the Dark Energy of Aging. Cell Syst. 2016 10 26; 3(4):328-330. Melov S. PMID: 27788357.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    31. Vitamin D Promotes Protein Homeostasis and Longevity via the Stress Response Pathway Genes skn-1, ire-1, and xbp-1. Cell Rep. 2016 10 25; 17(5):1227-1237. Mark KA, Dumas KJ, Bhaumik D, Schilling B, Davis S, Oron TR, Sorensen DJ, Lucanic M, Brem RB, Melov S, Ramanathan A, Gibson BW, Lithgow GJ. PMID: 27783938; PMCID: PMC5689451.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    32. Suppressors of Superoxide-H2O2 Production at Site IQ of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury. Cell Metab. 2016 10 11; 24(4):582-592. Brand MD, Goncalves RL, Orr AL, Vargas L, Gerencser AA, Borch Jensen M, Wang YT, Melov S, Turk CN, Matzen JT, Dardov VJ, Petrassi HM, Meeusen SL, Perevoshchikova IV, Jasper H, Brookes PS, Ainscow EK. PMID: 27667666; PMCID: PMC5061631.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    33. Geroscience approaches to increase healthspan and slow aging. F1000Res. 2016; 5. Melov S. PMID: 27158475; PMCID: PMC4856109.
      View in: PubMed   Mentions: 9     Fields:    
    34. Genomic Analysis Reveals Disruption of Striatal Neuronal Development and Therapeutic Targets in Human Huntington's Disease Neural Stem Cells. Stem Cell Reports. 2015 Dec 08; 5(6):1023-1038. Ring KL, An MC, Zhang N, O'Brien RN, Ramos EM, Gao F, Atwood R, Bailus BJ, Melov S, Mooney SD, Coppola G, Ellerby LM. PMID: 26651603; PMCID: PMC4682390.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    35. Pleiotropic age-dependent effects of mitochondrial dysfunction on epidermal stem cells. Proc Natl Acad Sci U S A. 2015 Aug 18; 112(33):10407-12. Velarde MC, Demaria M, Melov S, Campisi J. PMID: 26240345; PMCID: PMC4547253.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    36. Translational geroscience: emphasizing function to achieve optimal longevity. Aging (Albany NY). 2014 Sep; 6(9):718-30. Seals DR, Melov S. PMID: 25324468; PMCID: PMC4221919.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimals
    37. Medical research: treat ageing. Nature. 2014 Jul 24; 511(7510):405-7. Fontana L, Kennedy BK, Longo VD, Seals D, Melov S. PMID: 25056047.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansAnimals
    38. Germline signaling mediates the synergistically prolonged longevity produced by double mutations in daf-2 and rsks-1 in C. elegans. Cell Rep. 2013 Dec 26; 5(6):1600-10. Chen D, Li PW, Goldstein BA, Cai W, Thomas EL, Chen F, Hubbard AE, Melov S, Kapahi P. PMID: 24332851; PMCID: PMC3904953.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    39. Genome-wide DNA methylation changes with age in disease-free human skeletal muscle. Aging Cell. 2014 Apr; 13(2):360-6. Zykovich A, Hubbard A, Flynn JM, Tarnopolsky M, Fraga MF, Kerksick C, Ogborn D, MacNeil L, Mooney SD, Melov S. PMID: 24304487; PMCID: PMC3954952.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansCells
    40. Late-life rapamycin treatment reverses age-related heart dysfunction. Aging Cell. 2013 Oct; 12(5):851-62. Flynn JM, O'Leary MN, Zambataro CA, Academia EC, Presley MP, Garrett BJ, Zykovich A, Mooney SD, Strong R, Rosen CJ, Kapahi P, Nelson MD, Kennedy BK, Melov S. PMID: 23734717; PMCID: PMC4098908.
      View in: PubMed   Mentions: 169     Fields:    Translation:AnimalsCells
    41. Age-related micro-RNA abundance in individual C. elegans. Aging (Albany NY). 2013 Jun; 5(6):394-411. Lucanic M, Graham J, Scott G, Bhaumik D, Benz CC, Hubbard A, Lithgow GJ, Melov S. PMID: 23793570; PMCID: PMC3824409.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    42. SOD2 in mitochondrial dysfunction and neurodegeneration. Free Radic Biol Med. 2013 Sep; 62:4-12. Flynn JM, Melov S. PMID: 23727323; PMCID: PMC3811078.
      View in: PubMed   Mentions: 136     Fields:    Translation:HumansCells
    43. Single cell gene expression profiling of cortical osteoblast lineage cells. Bone. 2013 Mar; 53(1):174-81. Flynn JM, Spusta SC, Rosen CJ, Melov S. PMID: 23238121; PMCID: PMC3589579.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    44. No consistent bioenergetic defects in presynaptic nerve terminals isolated from mouse models of Alzheimer's disease. J Neurosci. 2012 Nov 21; 32(47):16775-84. Choi SW, Gerencser AA, Ng R, Flynn JM, Melov S, Danielson SR, Gibson BW, Nicholls DG, Bredesen DE, Brand MD. PMID: 23175831; PMCID: PMC3736741.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    45. Proteogenomics of synaptosomal mitochondrial oxidative stress. Free Radic Biol Med. 2012 Sep 01; 53(5):1048-60. Flynn JM, Czerwieniec GA, Choi SW, Day NU, Gibson BW, Hubbard A, Melov S. PMID: 22796328; PMCID: PMC3436120.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    46. Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster. Cell Metab. 2012 Jul 03; 16(1):97-103. Katewa SD, Demontis F, Kolipinski M, Hubbard A, Gill MS, Perrimon N, Melov S, Kapahi P. PMID: 22768842; PMCID: PMC3400463.
      View in: PubMed   Mentions: 91     Fields:    Translation:AnimalsCells
    47. Genetic correction of Huntington's disease phenotypes in induced pluripotent stem cells. Cell Stem Cell. 2012 Aug 03; 11(2):253-63. An MC, Zhang N, Scott G, Montoro D, Wittkop T, Mooney S, Melov S, Ellerby LM. PMID: 22748967; PMCID: PMC3608272.
      View in: PubMed   Mentions: 179     Fields:    Translation:HumansCells
    48. Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: implications for Parkinson's disease. Free Radic Biol Med. 2012 Aug 15; 53(4):993-1003. Siddiqui A, Chinta SJ, Mallajosyula JK, Rajagopolan S, Hanson I, Rane A, Melov S, Andersen JK. PMID: 22705949; PMCID: PMC3418424.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    49. Premature expression of a muscle fibrosis axis in chronic HIV infection. Skelet Muscle. 2012 Jun 07; 2(1):10. Kusko RL, Banerjee C, Long KK, Darcy A, Otis J, Sebastiani P, Melov S, Tarnopolsky M, Bhasin S, Montano M. PMID: 22676806; PMCID: PMC3407733.
      View in: PubMed   Mentions: 21     Fields:    
    50. cep-1/p53-dependent dysplastic pathology of the aging C. elegans gonad. Aging (Albany NY). 2012 Apr; 4(4):256-69. McGee MD, Day N, Graham J, Melov S. PMID: 22562940; PMCID: PMC3378273.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    51. Massage therapy attenuates inflammatory signaling after exercise-induced muscle damage. Sci Transl Med. 2012 Feb 01; 4(119):119ra13. Crane JD, Ogborn DI, Cupido C, Melov S, Hubbard A, Bourgeois JM, Tarnopolsky MA. PMID: 22301554.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansCells
    52. Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin. Aging (Albany NY). 2012 Jan; 4(1):3-12. Velarde MC, Flynn JM, Day NU, Melov S, Campisi J. PMID: 22278880; PMCID: PMC3292901.
      View in: PubMed   Mentions: 123     Fields:    Translation:HumansAnimalsCells
    53. Single cell transcriptional profiling of adult mouse cardiomyocytes. J Vis Exp. 2011 Dec 28; (58):e3302. Flynn JM, Santana LF, Melov S. PMID: 22231655; PMCID: PMC3369660.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    54. Human embryonic stem cells express elevated levels of multiple pro-apoptotic BCL-2 family members. PLoS One. 2011; 6(12):e28530. Madden DT, Davila-Kruger D, Melov S, Bredesen DE. PMID: 22174832; PMCID: PMC3235131.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    55. On the programmed/non-programmed nature of ageing within the life history. Curr Biol. 2011 Sep 27; 21(18):R701-7. Kirkwood TB, Melov S. PMID: 21959160.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimals
    56. Cellular senescence: a link between cancer and age-related degenerative disease? Semin Cancer Biol. 2011 Dec; 21(6):354-9. Campisi J, Andersen JK, Kapahi P, Melov S. PMID: 21925603; PMCID: PMC3230665.
      View in: PubMed   Mentions: 200     Fields:    Translation:Humans
    57. Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans. Cell Metab. 2011 Jul 06; 14(1):55-66. Rogers AN, Chen D, McColl G, Czerwieniec G, Felkey K, Gibson BW, Hubbard A, Melov S, Lithgow GJ, Kapahi P. PMID: 21723504; PMCID: PMC3220185.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    58. Loss of intestinal nuclei and intestinal integrity in aging C. elegans. Aging Cell. 2011 Aug; 10(4):699-710. McGee MD, Weber D, Day N, Vitelli C, Crippen D, Herndon LA, Hall DH, Melov S. PMID: 21501374; PMCID: PMC3135675.
      View in: PubMed   Mentions: 85     Fields:    Translation:AnimalsCells
    59. Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice. Proc Natl Acad Sci U S A. 2011 03 08; 108(10):4135-40. Safdar A, Bourgeois JM, Ogborn DI, Little JP, Hettinga BP, Akhtar M, Thompson JE, Melov S, Mocellin NJ, Kujoth GC, Prolla TA, Tarnopolsky MA. PMID: 21368114; PMCID: PMC3053975.
      View in: PubMed   Mentions: 157     Fields:    Translation:AnimalsCells
    60. The garlic constituent diallyl trisulfide increases the lifespan of C. elegans via skn-1 activation. Exp Gerontol. 2011 Jun; 46(6):441-52. Powolny AA, Singh SV, Melov S, Hubbard A, Fisher AL. PMID: 21296648; PMCID: PMC3104016.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    61. Impaired spare respiratory capacity in cortical synaptosomes from Sod2 null mice. Free Radic Biol Med. 2011 Apr 01; 50(7):866-73. Flynn JM, Choi SW, Day NU, Gerencser AA, Hubbard A, Melov S. PMID: 21215798; PMCID: PMC3061438.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    62. Insulin-like signaling determines survival during stress via posttranscriptional mechanisms in C. elegans. Cell Metab. 2010 Sep 08; 12(3):260-72. McColl G, Rogers AN, Alavez S, Hubbard AE, Melov S, Link CD, Bush AI, Kapahi P, Lithgow GJ. PMID: 20816092; PMCID: PMC2945254.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    63. Eccentric exercise activates novel transcriptional regulation of hypertrophic signaling pathways not affected by hormone changes. PLoS One. 2010 May 18; 5(5):e10695. MacNeil LG, Melov S, Hubbard AE, Baker SK, Tarnopolsky MA. PMID: 20502695; PMCID: PMC2872670.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    64. Limb immobilization induces a coordinate down-regulation of mitochondrial and other metabolic pathways in men and women. PLoS One. 2009 Aug 05; 4(8):e6518. Abadi A, Glover EI, Isfort RJ, Raha S, Safdar A, Yasuda N, Kaczor JJ, Melov S, Hubbard A, Qu X, Phillips SM, Tarnopolsky M. PMID: 19654872; PMCID: PMC2716517.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansCells
    65. A human protein interaction network shows conservation of aging processes between human and invertebrate species. PLoS Genet. 2009 Mar; 5(3):e1000414. Bell R, Hubbard A, Chettier R, Chen D, Miller JP, Kapahi P, Tarnopolsky M, Sahasrabuhde S, Melov S, Hughes RE. PMID: 19293945; PMCID: PMC2657003.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    66. Age-related behaviors have distinct transcriptional profiles in Caenorhabditis elegans. Aging Cell. 2008 Dec; 7(6):850-65. Golden TR, Hubbard A, Dando C, Herren MA, Melov S. PMID: 18778409; PMCID: PMC2613281.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    67. Increase in mitochondrial biogenesis, oxidative stress, and glycolysis in murine lymphomas. Free Radic Biol Med. 2009 Feb 01; 46(3):387-96. Samper E, Morgado L, Estrada JC, Bernad A, Hubbard A, Cadenas S, Melov S. PMID: 19038329; PMCID: PMC2665299.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    68. Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans. J Biol Chem. 2008 Jan 04; 283(1):350-357. McColl G, Killilea DW, Hubbard AE, Vantipalli MC, Melov S, Lithgow GJ. PMID: 17959600; PMCID: PMC2739662.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansAnimalsCells
    69. Global and targeted gene expression and protein content in skeletal muscle of young men following short-term creatine monohydrate supplementation. Physiol Genomics. 2008 Jan 17; 32(2):219-28. Safdar A, Yardley NJ, Snow R, Melov S, Tarnopolsky MA. PMID: 17957000.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    70. Mitochondrial oxidative stress causes hyperphosphorylation of tau. PLoS One. 2007 Jun 20; 2(6):e536. Melov S, Adlard PA, Morten K, Johnson F, Golden TR, Hinerfeld D, Schilling B, Mavros C, Masters CL, Volitakis I, Li QX, Laughton K, Hubbard A, Cherny RA, Gibson B, Bush AI. PMID: 17579710; PMCID: PMC1888726.
      View in: PubMed   Mentions: 158     Fields:    Translation:AnimalsCells
    71. Resistance exercise reverses aging in human skeletal muscle. PLoS One. 2007 May 23; 2(5):e465. Melov S, Tarnopolsky MA, Beckman K, Felkey K, Hubbard A. PMID: 17520024; PMCID: PMC1866181.
      View in: PubMed   Mentions: 129     Fields:    Translation:Humans
    72. Gene expression changes associated with aging in C. elegans. WormBook. 2007 Feb 12; 1-12. Golden TR, Melov S. PMID: 18050504; PMCID: PMC4781587.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    73. Dramatic age-related changes in nuclear and genome copy number in the nematode Caenorhabditis elegans. Aging Cell. 2007 Apr; 6(2):179-88. Golden TR, Beckman KB, Lee AH, Dudek N, Hubbard A, Samper E, Melov S. PMID: 17286610; PMCID: PMC2049047.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    74. Nigrostriatal dopaminergic neurodegeneration in the weaver mouse is mediated via neuroinflammation and alleviated by minocycline administration. J Neurosci. 2006 Nov 08; 26(45):11644-51. Peng J, Xie L, Stevenson FF, Melov S, Di Monte DA, Andersen JK. PMID: 17093086; PMCID: PMC6674792.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    75. Pol II-expressed shRNA knocks down Sod2 gene expression and causes phenotypes of the gene knockout in mice. PLoS Genet. 2006 Jan; 2(1):e10. Xia XG, Zhou H, Samper E, Melov S, Xu Z. PMID: 16450009; PMCID: PMC1358942.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    76. Mitochondrial reactive oxygen species in mice lacking superoxide dismutase 2: attenuation via antioxidant treatment. J Biol Chem. 2006 Feb 10; 281(6):3354-9. Morten KJ, Ackrell BA, Melov S. PMID: 16326710.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    77. Science fact and the SENS agenda. What can we reasonably expect from ageing research? EMBO Rep. 2005 Nov; 6(11):1006-8. Warner H, Anderson J, Austad S, Bergamini E, Bredesen D, Butler R, Carnes BA, Clark BF, Cristofalo V, Faulkner J, Guarente L, Harrison DE, Kirkwood T, Lithgow G, Martin G, Masoro E, Melov S, Miller RA, Olshansky SJ, Partridge L, Pereira-Smith O, Perls T, Richardson A, Smith J, von Zglinicki T, Wang E, Wei JY, Williams TF. PMID: 16264422; PMCID: PMC1371037.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    78. Biomarker discovery and analysis platform: application to Alzheimer's disease. Biotechniques. 2005 Oct; 39(4):606-7. Kuzdzal S, Lopez M, Mikulskis A, Golenko E, DiCesare J, Denoyer E, Patton W, Ediger R, Sapp L, Ziegert T, Ackloo S, Wall MR, Mannion DP, della Cioppa G, Wolfe G, Bennett D, Melov S. PMID: 16235574.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    79. Alzheimer disease beta-amyloid activity mimics cholesterol oxidase. J Clin Invest. 2005 Sep; 115(9):2556-63. Puglielli L, Friedlich AL, Setchell KD, Nagano S, Opazo C, Cherny RA, Barnham KJ, Wade JD, Melov S, Kovacs DM, Bush AI. PMID: 16127459; PMCID: PMC1190368.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    80. Hyperplasia, reduced E-cadherin expression, and developmental arrest in mammary glands oxidatively stressed by loss of mitochondrial superoxide dismutase. Breast. 2005 Aug; 14(4):256-63. Parmar H, Melov S, Samper E, Ljung BM, Cunha GR, Benz CC. PMID: 16085231.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    81. Pharmacogenomic profiling of an oxidative stress-mediated spongiform encephalopathy. Free Radic Biol Med. 2005 Jul 15; 39(2):152-63. Golden TR, Hubbard A, Morten KJ, Hinerfeld D, Melov S. PMID: 15964507.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    82. Mice transgenic for Alzheimer disease beta-amyloid develop lens cataracts that are rescued by antioxidant treatment. Free Radic Biol Med. 2005 Jan 15; 38(2):258-61. Melov S, Wolf N, Strozyk D, Doctrow SR, Bush AI. PMID: 15607908.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimals
    83. Microarrays as a tool to investigate the biology of aging: a retrospective and a look to the future. Sci Aging Knowledge Environ. 2004 Oct 20; 2004(42):re7. Melov S, Hubbard A. PMID: 15498758.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    84. Modeling mitochondrial function in aging neurons. Trends Neurosci. 2004 Oct; 27(10):601-6. Melov S. PMID: 15374671.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    85. Gene expression profiling in mitochondrial disease: assessment of microarray accuracy by high-throughput Q-PCR. Mitochondrion. 2004 Sep; 4(5-6):453-70. Beckman KB, Lee KY, Golden T, Melov S. PMID: 16120406.
      View in: PubMed   Mentions: 11     Fields:    
    86. Microscale fractionation facilitates detection of differentially expressed proteins in Alzheimer's disease brain samples. Electrophoresis. 2004 Aug; 25(15):2557-63. Lopez MF, Mikulskis A, Golenko E, Melov S, Bennett D, Cherkasskiy A, Kuzdzal S, Kramer S, Sissors D. PMID: 15300776.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    87. Microarray analysis of gene expression with age in individual nematodes. Aging Cell. 2004 Jun; 3(3):111-24. Golden TR, Melov S. PMID: 15153179.
      View in: PubMed   Mentions: 46     Fields:    Translation:Animals
    88. Endogenous mitochondrial oxidative stress: neurodegeneration, proteomic analysis, specific respiratory chain defects, and efficacious antioxidant therapy in superoxide dismutase 2 null mice. J Neurochem. 2004 Feb; 88(3):657-67. Hinerfeld D, Traini MD, Weinberger RP, Cochran B, Doctrow SR, Harry J, Melov S. PMID: 14720215.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    89. Proteomic analysis of mitochondrial proteins. Int Rev Neurobiol. 2004; 61:31-48. Lopez MF, Melov S, Johnson F, Nagulko N, Golenko E, Kuzdzal S, Ackloo S, Mikulskis A. PMID: 15482810.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    90. Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat Cell Biol. 2003 Aug; 5(8):741-7. Parrinello S, Samper E, Krtolica A, Goldstein J, Melov S, Campisi J. PMID: 12855956; PMCID: PMC4940195.
      View in: PubMed   Mentions: 480     Fields:    Translation:HumansAnimalsCells
    91. Microarray workshop on aging. Mech Ageing Dev. 2003 Jan; 124(1):133-8. Nair PN, Golden T, Melov S. PMID: 12618016.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    92. Oxidative stress and aging: beyond correlation. Aging Cell. 2002 Dec; 1(2):117-23. Golden TR, Hinerfeld DA, Melov S. PMID: 12882341.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansAnimalsCells
    93. Spotlight on nematode mitochondria in RNAi mega-screen. Sci Aging Knowledge Environ. 2002 Nov 27; 2002(47):pe18. Melov S. PMID: 14603016.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    94. Applied proteomics: mitochondrial proteins and effect on function. Circ Res. 2002 Mar 08; 90(4):380-9. Lopez MF, Melov S. PMID: 11884366.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    95. '...and C is for Clioquinol' - the AbetaCs of Alzheimer's disease. Trends Neurosci. 2002 Mar; 25(3):121-3; discussion 123-4. Melov S. PMID: 11852134.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
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