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    Francisco Valero-Cuevas, PhD

    TitleProfessor
    SchoolViterbi School of Engineering, BME
    DepartmentBiomedical Engineering
    AddressRTH 404
    University Park Campus
    Los Angeles California 90089-2905
    Phone+1 213 821 2084
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      Collapse Overview 
      Collapse Overview
      I attended Swarthmore College from 1984-88 where I obtained a BS degree in Engineering. After spending a year in the Indian subcontinent as a Thomas J Watson Fellow, I joined Queen's University in Ontario and worked with Dr. Carolyn Small. The research for my Masters Degree in Mechanical Engineering at Queen's focused on developing non-invasive methods to estimate the kinematic integrity of the wrist joint.

      In 1991, I joined the doctoral program in the Design Division of the Mechanical Engineering Department at Stanford University. I worked with Dr. Felix Zajac developing a realistic biomechanical model of the human digits. This research, done at the Rehabilitation R & D Center in Palo Alto, focused on predicting optimal coordination patterns of finger musculature during static force production.
      After completing my doctoral degree in 1997, I joined the core faculty of the Biomechanical Engineering Division at Stanford University as a Research Associate and Lecturer. In 1999, I joined the faculty of the Sibley School of Mechanical and Aerospace Engineering at Cornell University as Assistant Professor, and was tenured in 2005. In 2007, I joined the faculty at the Department of Biomedical Engineering, and the Division of Biokinesiology & Physical Therapy at the University of Southern California as Associate Professor; where I was promoted to Full Professor in 2011. In 2013 I was elected Senior Member of the IEEE, and in 2014 to the College of Fellows of the American Institute for Medical and Biological Engineers.


      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Lawrence EL, Peppoloni L, Valero-Cuevas F. Sex differences in leg dexterity are not present in elite athletes. J Biomech. 2017 Sep 14. PMID: 28943154.
        View in: PubMed
      2. Laine CM, Valero-Cuevas F. Intermuscular coherence reflects functional coordination. J Neurophysiol. 2017 Sep 01; 118(3):1775-1783. PMID: 28659460.
        View in: PubMed
      3. von Walden F, Jalaleddini K, Evertsson B, Friberg J, Valero-Cuevas F, Pontén E. Forearm Flexor Muscles in Children with Cerebral Palsy Are Weak, Thin and Stiff. Front Comput Neurosci. 2017; 11:30. PMID: 28487645.
        View in: PubMed
      4. Reyes A, Laine CM, Kutch JJ, Valero-Cuevas F. Beta Band Corticomuscular Drive Reflects Muscle Coordination Strategies. Front Comput Neurosci. 2017; 11:17. PMID: 28420975.
        View in: PubMed
      5. Jalaleddini K, Minos Niu C, Chakravarthi Raja S, Joon Sohn W, Loeb GE, Sanger TD, Valero-Cuevas F. Neuromorphic meets neuromechanics, part II: the role of fusimotor drive. J Neural Eng. 2017 Apr; 14(2):025002. PMID: 28094764.
        View in: PubMed
      6. Valero-Cuevas F, Klamroth-Marganska V, Winstein CJ, Riener R. Erratum to: Robot-assisted and conventional therapies produce distinct rehabilitative trends in stroke survivors. J Neuroeng Rehabil. 2016 Dec 06; 13(1):101. PMID: 27923391.
        View in: PubMed
      7. Nagamori A, Valero-Cuevas F, Finley JM. Unilateral Eccentric Contraction of the Plantarflexors Leads to Bilateral Alterations in Leg Dexterity. Front Physiol. 2016; 7:582. PMID: 27965588.
        View in: PubMed
      8. Valero-Cuevas F, Klamroth-Marganska V, Winstein CJ, Riener R. Robot-assisted and conventional therapies produce distinct rehabilitative trends in stroke survivors. J Neuroeng Rehabil. 2016 Oct 11; 13(1):92. PMID: 27724916.
        View in: PubMed
      9. Laine CM, Nagamori A, Valero-Cuevas F. The Dynamics of Voluntary Force Production in Afferented Muscle Influence Involuntary Tremor. Front Comput Neurosci. 2016; 10:86. PMID: 27594832; PMCID: PMC4990560.
      10. Brock O, Valero-Cuevas F. Transferring synergies from neuroscience to robotics: Comment on "Hand synergies: Integration of robotics and neuroscience for understanding the control of biological and artificial hands" by M. Santello et al. Phys Life Rev. 2016 Jul; 17:27-32. PMID: 27212396.
        View in: PubMed
      11. Inouye JM, Valero-Cuevas F. Muscle Synergies Heavily Influence the Neural Control of Arm Endpoint Stiffness and Energy Consumption. PLoS Comput Biol. 2016 Feb; 12(2):e1004737. PMID: 26867014; PMCID: PMC4750997.
      12. Lawrence EL, Cesar GM, Bromfield MR, Peterson R, Valero-Cuevas F, Sigward SM. Strength, Multijoint Coordination, and Sensorimotor Processing Are Independent Contributors to Overall Balance Ability. Biomed Res Int. 2015; 2015:561243. PMID: 26665007.
        View in: PubMed
      13. Ko NH, Laine CM, Fisher BE, Valero-Cuevas F. Force Variability during Dexterous Manipulation in Individuals with Mild to Moderate Parkinson's Disease. Front Aging Neurosci. 2015; 7:151. PMID: 26321947; PMCID: PMC4530309.
      14. Lawrence EL, Dayanidhi S, Fassola I, Requejo P, Leclercq C, Winstein CJ, Valero-Cuevas F. Outcome measures for hand function naturally reveal three latent domains in older adults: strength, coordinated upper extremity function, and sensorimotor processing. Front Aging Neurosci. 2015; 7:108. PMID: 26097455; PMCID: PMC4456581.
      15. Pavlova E, Hedberg Å, Ponten E, Gantelius S, Valero-Cuevas F, Forssberg H. Activity in the brain network for dynamic manipulation of unstable objects is robust to acute tactile nerve block: An fMRI study. Brain Res. 2015 Sep 16; 1620:98-106. PMID: 25998541.
        View in: PubMed
      16. Duff SV, Aaron DH, Gogola GR, Valero-Cuevas F. Innovative evaluation of dexterity in pediatrics. J Hand Ther. 2015 Apr-Jun; 28(2):144-9; quiz 150. PMID: 25835255; PMCID: PMC4424153.
      17. Lightdale-Miric N, Mueske NM, Lawrence EL, Loiselle J, Berggren J, Dayanidhi S, Stevanovic M, Valero-Cuevas F, Wren TA. Long term functional outcomes after early childhood pollicization. J Hand Ther. 2015 Apr-Jun; 28(2):158-65; quiz 166. PMID: 25835252; PMCID: PMC4424177.
      18. Lightdale-Miric N, Mueske NM, Dayanidhi S, Loiselle J, Berggren J, Lawrence EL, Stevanovic M, Valero-Cuevas F, Wren TA. Quantitative assessment of dynamic control of fingertip forces after pollicization. Gait Posture. 2015 Jan; 41(1):1-6. PMID: 25262333; PMCID: PMC4267977.
      19. Lawrence EL, Fassola I, Werner I, Leclercq C, Valero-Cuevas F. Quantification of dexterity as the dynamical regulation of instabilities: comparisons across gender, age, and disease. Front Neurol. 2014; 5:53. PMID: 24782824; PMCID: PMC3995042.
      20. Dayanidhi S, Valero-Cuevas F. Dexterous manipulation is poorer at older ages and is dissociated from decline of hand strength. J Gerontol A Biol Sci Med Sci. 2014 Sep; 69(9):1139-45. PMID: 24610868; PMCID: PMC4202259.
      21. Lyle MA, Valero-Cuevas F, Gregor RJ, Powers CM. Lower extremity dexterity is associated with agility in adolescent soccer athletes. Scand J Med Sci Sports. 2015 Feb; 25(1):81-8. PMID: 24325628; PMCID: PMC4053489.
      22. Rácz K, Valero-Cuevas F. Spatio-temporal analysis reveals active control of both task-relevant and task-irrelevant variables. Front Comput Neurosci. 2013; 7:155. PMID: 24312045; PMCID: PMC3826108.
      23. Lyle MA, Valero-Cuevas F, Gregor RJ, Powers CM. Control of dynamic foot-ground interactions in male and female soccer athletes: females exhibit reduced dexterity and higher limb stiffness during landing. J Biomech. 2014 Jan 22; 47(2):512-7. PMID: 24275440; PMCID: PMC3947591.
      24. Dayanidhi S, Kutch JJ, Valero-Cuevas F. Decrease in muscle contraction time complements neural maturation in the development of dynamic manipulation. J Neurosci. 2013 Sep 18; 33(38):15050-5. PMID: 24048835; PMCID: PMC3776057.
      25. Dayanidhi S, Hedberg A, Valero-Cuevas F, Forssberg H. Developmental improvements in dynamic control of fingertip forces last throughout childhood and into adolescence. J Neurophysiol. 2013 Oct; 110(7):1583-92. PMID: 23864371; PMCID: PMC4042419.
      26. Lyle MA, Valero-Cuevas F, Gregor RJ, Powers CM. The lower extremity dexterity test as a measure of lower extremity dynamical capability. J Biomech. 2013 Mar 15; 46(5):998-1002. PMID: 23357699.
        View in: PubMed
      27. Towles JD, Valero-Cuevas F, Hentz VR. Capacity of small groups of muscles to accomplish precision grasping tasks. Conf Proc IEEE Eng Med Biol Soc. 2013; 2013:6583-6. PMID: 24111251.
        View in: PubMed
      28. Saxena A, Lipson H, Valero-Cuevas F. Functional inference of complex anatomical tendinous networks at a macroscopic scale via sparse experimentation. PLoS Comput Biol. 2012; 8(11):e1002751. PMID: 23144601; PMCID: PMC3493461.
      29. Rácz K, Brown D, Valero-Cuevas F. An involuntary stereotypical grasp tendency pervades voluntary dynamic multifinger manipulation. J Neurophysiol. 2012 Dec; 108(11):2896-911. PMID: 22956798; PMCID: PMC3544870.
      30. Inouye JM, Kutch JJ, Valero-Cuevas F. A Novel Synthesis of Computational Approaches Enables Optimization of Grasp Quality of Tendon-Driven Hands. IEEE Trans Robot. 2012 Aug; 28(4):958-966. PMID: 23335864.
        View in: PubMed
      31. Kutch JJ, Valero-Cuevas F. Challenges and new approaches to proving the existence of muscle synergies of neural origin. PLoS Comput Biol. 2012; 8(5):e1002434. PMID: 22570602; PMCID: PMC3342930.
      32. Kurse MU, Lipson H, Valero-Cuevas F. Extrapolatable analytical functions for tendon excursions and moment arms from sparse datasets. IEEE Trans Biomed Eng. 2012 Jun; 59(6):1572-82. PMID: 22410321; PMCID: PMC3549398.
      33. Holmström L, de Manzano O, Vollmer B, Forsman L, Valero-Cuevas F, Ullén F, Forssberg H. Dissociation of brain areas associated with force production and stabilization during manipulation of unstable objects. Exp Brain Res. 2011 Dec; 215(3-4):359-67. PMID: 22038714; PMCID: PMC3950331.
      34. Kutch JJ, Valero-Cuevas F. Muscle redundancy does not imply robustness to muscle dysfunction. J Biomech. 2011 Apr 29; 44(7):1264-70. PMID: 21420091; PMCID: PMC3090003.
      35. Mosier K, Lau C, Wang Y, Venkadesan M, Valero-Cuevas F. Controlling instabilities in manipulation requires specific cortical-striatal-cerebellar networks. J Neurophysiol. 2011 Mar; 105(3):1295-305. PMID: 21228301; PMCID: PMC3074419.
      36. Sanger TD, Chen D, Fehlings DL, Hallett M, Lang AE, Mink JW, Singer HS, Alter K, Ben-Pazi H, Butler EE, Chen R, Collins A, Dayanidhi S, Forssberg H, Fowler E, Gilbert DL, Gorman SL, Gormley ME, Jinnah HA, Kornblau B, Krosschell KJ, Lehman RK, MacKinnon C, Malanga CJ, Mesterman R, Michaels MB, Pearson TS, Rose J, Russman BS, Sternad D, Swoboda KJ, Valero-Cuevas F. Definition and classification of hyperkinetic movements in childhood. Mov Disord. 2010 Aug 15; 25(11):1538-49. PMID: 20589866; PMCID: PMC2929378.
      37. Vollmer B, Holmström L, Forsman L, Krumlinde-Sundholm L, Valero-Cuevas F, Forssberg H, Ullén F. Evidence of validity in a new method for measurement of dexterity in children and adolescents. Dev Med Child Neurol. 2010 Oct; 52(10):948-54. PMID: 20497459; PMCID: PMC3080099.
      38. Lange BS, Requejo P, Flynn SM, Rizzo AA, Valero-Cuevas F, Baker L, Winstein C. The potential of virtual reality and gaming to assist successful aging with disability. Phys Med Rehabil Clin N Am. 2010 May; 21(2):339-56. PMID: 20494281.
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      39. Sherback M, Valero-Cuevas F, D'Andrea R. Slower visuomotor corrections with unchanged latency are consistent with optimal adaptation to increased endogenous noise in the elderly. PLoS Comput Biol. 2010 Mar 12; 6(3):e1000708. PMID: 20300648; PMCID: PMC2837393.
      40. Theodorou E, Valero-Cuevas F. Optimality in neuromuscular systems. Conf Proc IEEE Eng Med Biol Soc. 2010; 2010:4510-6. PMID: 21095783.
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      41. Kutch JJ, Valero-Cuevas F. Computational hypothesis testing for neuromuscular systems. Conf Proc IEEE Eng Med Biol Soc. 2010; 2010:5436-9. PMID: 21096278.
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      42. Cianchetti FA, Valero-Cuevas F. Anticipatory control of motion-to-force transitions with the fingertips adapts optimally to task difficulty. J Neurophysiol. 2010 Jan; 103(1):108-16. PMID: 19889857; PMCID: PMC2807214.
      43. Rieffel JA, Valero-Cuevas F, Lipson H. Morphological communication: exploiting coupled dynamics in a complex mechanical structure to achieve locomotion. J R Soc Interface. 2010 Apr 06; 7(45):613-21. PMID: 19776146; PMCID: PMC2842775.
      44. Keenan KG, Santos VJ, Venkadesan M, Valero-Cuevas F. Maximal voluntary fingertip force production is not limited by movement speed in combined motion and force tasks. J Neurosci. 2009 Jul 08; 29(27):8784-9. PMID: 19587285; PMCID: PMC2763542.
      45. Valero-Cuevas F, Venkadesan M, Todorov E. Structured variability of muscle activations supports the minimal intervention principle of motor control. J Neurophysiol. 2009 Jul; 102(1):59-68. PMID: 19369362; PMCID: PMC2712269.
      46. Venkadesan M, Valero-Cuevas F. Effects of neuromuscular lags on controlling contact transitions. Philos Trans A Math Phys Eng Sci. 2009 Mar 28; 367(1891):1163-79. PMID: 19218157; PMCID: PMC2635488.
      47. Valero-Cuevas F. A mathematical approach to the mechanical capabilities of limbs and fingers. Adv Exp Med Biol. 2009; 629:619-33. PMID: 19227524; PMCID: PMC2839389.
      48. Valero-Cuevas F. Why the hand? Adv Exp Med Biol. 2009; 629:553-7. PMID: 19227520.
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      49. Valero-Cuevas F, Hoffmann H, Kurse MU, Kutch JJ, Theodorou EA. Computational Models for Neuromuscular Function. IEEE Rev Biomed Eng. 2009; 2:110-135. PMID: 21687779.
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      50. Santos VJ, Bustamante CD, Valero-Cuevas F. Improving the fitness of high-dimensional biomechanical models via data-driven stochastic exploration. IEEE Trans Biomed Eng. 2009 Mar; 56(3):552-64. PMID: 19272906; PMCID: PMC2841988.
      51. Keenan KG, Valero-Cuevas F. Epoch length to accurately estimate the amplitude of interference EMG is likely the result of unavoidable amplitude cancellation. Biomed Signal Process Control. 2008 Apr; 3(2):154-162. PMID: 19081815.
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      52. Venkadesan M, Valero-Cuevas F. Neural control of motion-to-force transitions with the fingertip. J Neurosci. 2008 Feb 06; 28(6):1366-73. PMID: 18256256; PMCID: PMC2840633.
      53. Clewley RH, Guckenheimer JM, Valero-Cuevas F. Estimating effective degrees of freedom in motor systems. IEEE Trans Biomed Eng. 2008 Feb; 55(2 Pt 1):430-42. PMID: 18269978.
        View in: PubMed
      54. Valero-Cuevas F, Anand VV, Saxena A, Lipson H. Beyond parameter estimation: extending biomechanical modeling by the explicit exploration of model topology. IEEE Trans Biomed Eng. 2007 Nov; 54(11):1951-64. PMID: 18018690.
        View in: PubMed
      55. Keenan KG, Valero-Cuevas F. Experimentally valid predictions of muscle force and EMG in models of motor-unit function are most sensitive to neural properties. J Neurophysiol. 2007 Sep; 98(3):1581-90. PMID: 17615125.
        View in: PubMed
      56. Valero-Cuevas F, Yi JW, Brown D, McNamara RV, Paul C, Lipson H. The tendon network of the fingers performs anatomical computation at a macroscopic scale. IEEE Trans Biomed Eng. 2007 Jun; 54(6 Pt 2):1161-6. PMID: 17549909.
        View in: PubMed
      57. Venkadesan M, Guckenheimer J, Valero-Cuevas F. Manipulating the edge of instability. J Biomech. 2007; 40(8):1653-61. PMID: 17400231; PMCID: PMC2666355.
      58. Santos VJ, Valero-Cuevas F. Reported anatomical variability naturally leads to multimodal distributions of Denavit-Hartenberg parameters for the human thumb. IEEE Trans Biomed Eng. 2006 Feb; 53(2):155-63. PMID: 16485744.
        View in: PubMed
      59. Talati A, Valero-Cuevas F, Hirsch J. Visual and tactile guidance of dexterous manipulation tasks: an fMRI study. Percept Mot Skills. 2005 Aug; 101(1):317-34. PMID: 16353365.
        View in: PubMed
      60. Kuxhaus L, Roach SS, Valero-Cuevas F. Quantifying deficits in the 3D force capabilities of a digit caused by selective paralysis: application to the thumb with simulated low ulnar nerve palsy. J Biomech. 2005 Apr; 38(4):725-36. PMID: 15713293.
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      61. Valero-Cuevas F. An integrative approach to the biomechanical function and neuromuscular control of the fingers. J Biomech. 2005 Apr; 38(4):673-84. PMID: 15713287.
        View in: PubMed
      62. Pearlman JL, Roach SS, Valero-Cuevas F. The fundamental thumb-tip force vectors produced by the muscles of the thumb. J Orthop Res. 2004 Mar; 22(2):306-12. PMID: 15013089.
        View in: PubMed
      63. Valero-Cuevas F, Lipson H. A computational environment to simulate complex tendinous topologies. Conf Proc IEEE Eng Med Biol Soc. 2004; 6:4653-6. PMID: 17271345.
        View in: PubMed
      64. Santos VJ, Valero-Cuevas F. A Bayesian approach to biomechanical modeling to optimize over large parameter spaces while considering anatomical variability. Conf Proc IEEE Eng Med Biol Soc. 2004; 6:4626-9. PMID: 17271338.
        View in: PubMed
      65. Valero-Cuevas F, Johanson ME, Towles JD. Towards a realistic biomechanical model of the thumb: the choice of kinematic description may be more critical than the solution method or the variability/uncertainty of musculoskeletal parameters. J Biomech. 2003 Jul; 36(7):1019-30. PMID: 12757811.
        View in: PubMed
      66. Valero-Cuevas F, Smaby N, Venkadesan M, Peterson M, Wright T. The strength-dexterity test as a measure of dynamic pinch performance. J Biomech. 2003 Feb; 36(2):265-70. PMID: 12547365.
        View in: PubMed
      67. Valero-Cuevas F, Hentz VR. Releasing the A3 pulley and leaving flexor superficialis intact increases pinch force following the Zancolli lasso procedures to prevent claw deformity in the intrinsic palsied finger. J Orthop Res. 2002 Sep; 20(5):902-9. PMID: 12382952.
        View in: PubMed
      68. Johanson ME, Valero-Cuevas F, Hentz VR. Activation patterns of the thumb muscles during stable and unstable pinch tasks. J Hand Surg Am. 2001 Jul; 26(4):698-705. PMID: 11466647.
        View in: PubMed
      69. Valero-Cuevas F, Towles JD, Hentz VR. Quantification of fingertip force reduction in the forefinger following simulated paralysis of extensor and intrinsic muscles. J Biomech. 2000 Dec; 33(12):1601-9. PMID: 11006384.
        View in: PubMed
      70. Valero-Cuevas F. Predictive modulation of muscle coordination pattern magnitude scales fingertip force magnitude over the voluntary range. J Neurophysiol. 2000 Mar; 83(3):1469-79. PMID: 10712473.
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      71. Valero-Cuevas F, Zajac FE, Burgar CG. Large index-fingertip forces are produced by subject-independent patterns of muscle excitation. J Biomech. 1998 Aug; 31(8):693-703. PMID: 9796669.
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      72. Burgar CG, Valero-Cuevas F, Hentz VR. Fine-wire electromyographic recording during force generation. Application to index finger kinesiologic studies. Am J Phys Med Rehabil. 1997 Nov-Dec; 76(6):494-501. PMID: 9431269.
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