Sarah Richman

Title(s)Assistant Professor of Pediatrics
Address4640 West Sunset Blvd
Off Campus
Los Angeles CA 90027
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    Collapse Education and Training
    Princeton University, Princeton, NJAB06/2001Molecular Biology
    University of Illinois at Urbana-Champaign, Urbana, ILPhD05/2007Biochemistry
    University of Illinois at Urbana-Champaign, Urbana, ILMD05/2010
    Children's Hospital of New York, Columbia University Medical Center, New York, NY06/2013Residency, Pediatrics
    Children's Hospital of Philadelphia, Philadelphia, PA06/2016Fellowship, Hematology-Oncology

    Collapse Overview 
    Collapse Overview
    The lab at Children's Hospital Los Angeles (CHLA) is focused on developing chimeric antigen receptor (CAR) T cells targeting solid tumors.

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ligand-Induced Degradation of a CAR Permits Reversible Remote Control of CAR T Cell Activity In Vitro and In Vivo. Mol Ther. 2020 Aug 05; 28(8):1932. Richman SA, Wang LC, Moon EK, Khire UR, Albelda SM, Milone MC. PMID: 32697941.
      View in: PubMed   Mentions: 1     Fields:    
    2. Enhancing Chimeric Antigen Receptor T Cell Anti-tumor Function through Advanced Media Design. Mol Ther Methods Clin Dev. 2020 Sep 11; 18:595-606. Ghassemi S, Martinez-Becerra FJ, Master AM, Richman SA, Heo D, Leferovich J, Tu Y, García-Cañaveras JC, Ayari A, Lu Y, Wang A, Rabinowitz JD, Milone MC, June CH, O'Connor RS. PMID: 32775494.
      View in: PubMed   Mentions:
    3. Ligand-Induced Degradation of a CAR Permits Reversible Remote Control of CAR T Cell Activity In Vitro and In Vivo. Mol Ther. 2020 07 08; 28(7):1600-1613. Richman SA, Wang LC, Moon EK, Khire UR, Albelda SM, Milone MC. PMID: 32559430.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    4. Imaging CAR T Cell Trafficking with eDHFR as a PET Reporter Gene. Mol Ther. 2020 01 08; 28(1):42-51. Sellmyer MA, Richman SA, Lohith K, Hou C, Weng CC, Mach RH, O'Connor RS, Milone MC, Farwell MD. PMID: 31668558.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    5. ß-synuclein at the "synapse" of encephalitis and neurodegeneration in multiple sclerosis? Immunol Cell Biol. 2019 07; 97(6):523-525. Richman SA, Hunter CA. PMID: 31190448.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    6. Neurotoxicity Associated with a High-Affinity GD2 CAR-Response. Cancer Immunol Res. 2018 04; 6(4):496-497. Richman SA, Milone MC. PMID: 29610424.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    7. High-Affinity GD2-Specific CAR T Cells Induce Fatal Encephalitis in a Preclinical Neuroblastoma Model. Cancer Immunol Res. 2018 01; 6(1):36-46. Richman SA, Nunez-Cruz S, Moghimi B, Li LZ, Gershenson ZT, Mourelatos Z, Barrett DM, Grupp SA, Milone MC. PMID: 29180536.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    8. Enhanced-affinity murine T-cell receptors for tumor/self-antigens can be safe in gene therapy despite surpassing the threshold for thymic selection. Blood. 2013 Jul 18; 122(3):348-56. Schmitt TM, Aggen DH, Stromnes IM, Dossett ML, Richman SA, Kranz DM, Greenberg PD. PMID: 23673862.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    9. Single-chain VaVß T-cell receptors function without mispairing with endogenous TCR chains. Gene Ther. 2012 Apr; 19(4):365-74. Aggen DH, Chervin AS, Schmitt TM, Engels B, Stone JD, Richman SA, Piepenbrink KH, Baker BM, Greenberg PD, Schreiber H, Kranz DM. PMID: 21753797.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    10. Biosensor detection systems: engineering stable, high-affinity bioreceptors by yeast surface display. Methods Mol Biol. 2009; 504:323-50. Richman SA, Kranz DM, Stone JD. PMID: 19159105.
      View in: PubMed   Mentions: 8     Fields:    
    11. Structural features of T cell receptor variable regions that enhance domain stability and enable expression as single-chain ValphaVbeta fragments. Mol Immunol. 2009 Feb; 46(5):902-16. Richman SA, Aggen DH, Dossett ML, Donermeyer DL, Allen PM, Greenberg PD, Kranz DM. PMID: 18962897.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    12. Display, engineering, and applications of antigen-specific T cell receptors. Biomol Eng. 2007 Oct; 24(4):361-73. Richman SA, Kranz DM. PMID: 17409021.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    13. Development of a novel strategy for engineering high-affinity proteins by yeast display. Protein Eng Des Sel. 2006 Jun; 19(6):255-64. Richman SA, Healan SJ, Weber KS, Donermeyer DL, Dossett ML, Greenberg PD, Allen PM, Kranz DM. PMID: 16549400.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
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    NIH Funding Acknowledgment: Important - All publications resulting from the utilization of SC CTSI resources are required to credit the SC CTSI grant by including the NIH funding acknowledgment and must comply with the NIH Public Access Policy.

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