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Cumulative Laxation Response with Methylnaltrexone: Implications for Hospitalized Patients with Advanced Illness and Opioid-Induced Constipation. Curr Ther Res Clin Exp. 2023; 98:100694.
Farchadi D, Slatkin NE, Stambler N, Israel RJ, Matus M. PMID: 36875317; PMCID: PMC9981808.
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A Randomized, Double-Blind, Parallel Design Thorough QT Study With a Nested Crossover to Compare the Cardiac Safety of Amiselimod With Placebo and Positive Control in Healthy Volunteers. Clin Pharmacol Drug Dev. 2023 Jan 28.
Lee J, Lester R, O'Reilly T, Lowe ER, Slatkin NE, Franklin H, Israel RJ. PMID: 36708138.
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Reductions in All-Cause Mortality Associated with the Use of Methylnaltrexone for Opioid-Induced Bowel Disorders: A Pooled Analysis. Pain Med. 2022 Sep 14.
Webster LR, Brenner D, Israel RJ, Stambler N, Slatkin NE. PMID: 36102822.
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A randomized, placebo-controlled study to evaluate safety and pharmacokinetics of inhaled ribavirin. Clin Transl Sci. 2022 09; 15(9):2159-2171.
Couroux P, Brkovic A, Vittitow JL, Israel RJ, Pamidi C, Patel J, Barakat M. PMID: 35677972; PMCID: PMC9468560.
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2 Fields:
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First-Dose Efficacy of Methylnaltrexone in Patients with Severe Medical Illness and Opioid-Induced Constipation: A Pooled Analysis. J Emerg Med. 2022 02; 62(2):231-239.
Peacock WF, Slatkin NE, Israel RJ, Stambler N. PMID: 34893381.
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Humans
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Attrition of methylnaltrexone treatment-emergent adverse events in patients with chronic noncancer pain and opioid-induced constipation: a post hoc pooled analysis of two clinical trials. F1000Res. 2021; 10:891.
Mehta N, Slatkin NE, Israel RJ, Stambler N. PMID: 34631030; PMCID: PMC8485099.
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1 Fields:
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Humans
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Subcutaneous Methylnaltrexone for Treatment of Opioid-Induced Constipation in Cancer versus Noncancer Patients: An Analysis of Efficacy and Safety Variables from Two Studies. J Pain Res. 2021; 14:2687-2697.
Chamberlain BH, Rhiner M, Slatkin NE, Stambler N, Israel RJ. PMID: 34512008; PMCID: PMC8420564.
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1
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The influence of brain metastases on the central nervous system effects of methylnaltrexone: a post hoc analysis of 3 randomized, double-blind studies. Support Care Cancer. 2021 Sep; 29(9):5209-5218.
Brenner DM, Slatkin NE, Stambler N, Israel RJ, Coluzzi PH. PMID: 33629189; PMCID: PMC8295095.
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Subcutaneous methylnaltrexone for opioid-induced constipation in advanced-illness patients with or without active cancer. Pain Manag. 2020 Mar; 10(2):73-84.
Chamberlain BH, Rhiner M, Slatkin NE, Stambler N, Israel RJ. PMID: 31951150.
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3 Fields:
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HumansCTClinical Trials
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Safety of oral methylnaltrexone for opioid-induced constipation in patients with chronic noncancer pain. J Pain Res. 2019; 12:139-150.
Rauck RL, Slatkin NE, Stambler N, Israel RJ. PMID: 30613162; PMCID: PMC6307492.
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2
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Randomized, Double-Blind Trial of Oral Methylnaltrexone for the Treatment of Opioid-Induced Constipation in Patients with Chronic Noncancer Pain. Pain Pract. 2017 07; 17(6):820-828.
Rauck R, Slatkin NE, Stambler N, Harper JR, Israel RJ. PMID: 27860208.
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26 Fields:
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HumansCTClinical Trials
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Fixed-Dose Subcutaneous Methylnaltrexone in Patients with Advanced Illness and Opioid-Induced Constipation: Results of a Randomized, Placebo-Controlled Study and Open-Label Extension. J Palliat Med. 2015 Jul; 18(7):593-600.
Bull J, Wellman CV, Israel RJ, Barrett AC, Paterson C, Forbes WP. PMID: 25973526; PMCID: PMC4492709.
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20 Fields:
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Characterization of abdominal pain during methylnaltrexone treatment of opioid-induced constipation in advanced illness: a post hoc analysis of two clinical trials. J Pain Symptom Manage. 2011 Nov; 42(5):754-60.
Slatkin NE, Lynn R, Su C, Wang W, Israel RJ. PMID: 22045373.
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12 Fields:
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Methylnaltrexone for treatment of opioid-induced constipation in advanced illness patients. J Support Oncol. 2009 Jan-Feb; 7(1):39-46.
Slatkin N, Thomas J, Lipman AG, Wilson G, Boatwright ML, Wellman C, Zhukovsky DS, Stephenson R, Portenoy R, Stambler N, Israel R. PMID: 19278178.
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55 Fields:
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Methylnaltrexone for opioid-induced constipation in advanced illness. N Engl J Med. 2008 May 29; 358(22):2332-43.
Thomas J, Karver S, Cooney GA, Chamberlain BH, Watt CK, Slatkin NE, Stambler N, Kremer AB, Israel RJ. PMID: 18509120.
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124 Fields:
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HumansCTClinical Trials
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Subcutaneous methylnaltrexone for the treatment of opioid-induced constipation in patients with advanced illness: a double-blind, randomized, parallel group, dose-ranging study. J Pain Symptom Manage. 2008 May; 35(5):458-68.
Portenoy RK, Thomas J, Moehl Boatwright ML, Tran D, Galasso FL, Stambler N, Von Gunten CF, Israel RJ. PMID: 18440447.
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39 Fields:
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The relationship between physicians and industry: Faustian or symbiotic? Am J Obstet Gynecol. 2003 Jun; 188(6):1530-40.
Israel R. PMID: 12824990.
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Evaluation of a large cohort of men presenting for a screening semen analysis. Fertil Steril. 2000 Mar; 73(3):595-7.
Acacio BD, Gottfried T, Israel R, Sokol RZ. PMID: 10689019.
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15 Fields:
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HumansCells