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Leprosy-Insufficient Evidence for Monthly Multidrug Therapy. JAMA Dermatol. 2024 Jul 01; 160(7):785.
Adler BL, Harnisch JP, Ochoa MT. PMID: 38809538.
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PubMed Mentions: Fields:
Translation:
Humans
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Shared decision-making in psoriasis care: Evaluation of how patients' perception of clinicians' delivery of care changes by age and sex. PLoS One. 2024; 19(5):e0303058.
Kikuchi R, Kingston P, Hao A, Sadrolashrafi K, Yamamoto RK, Tolson H, Bilimoria SN, Guo L, Yee D, Ochoa MT, Armstrong AW. PMID: 38728289; PMCID: PMC11086864.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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More on Autochthonous Leprosy in the United States. Reply. N Engl J Med. 2023 Sep 07; 389(10):963-964.
Adler BL, Ochoa MT. PMID: 37672709.
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PubMed Mentions: Fields:
Translation:
Humans
-
Mpox (Monkeypox) Clinical Pearls. Cutis. 2023 04; 111(4):170-171.
Peterson H, Adler BL, Ochoa MT. PMID: 37289689.
View in:
PubMed Mentions:
1 Fields:
Translation:
Humans
-
Impact of Mycobacterium leprae and Mycobacterium lepromatosis on immune reactions and clinical outcomes in Hansen's disease: A single-center retrospective analysis. J Am Acad Dermatol. 2023 Mar; 88(3):722-724.
Khan S, Adler BL, Armstrong AW, Lahiri R, Ochoa MT. PMID: 36156303.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Editorial: Strategies Played by Immune Cells and Mycobacteria in the Battle Between Antimicrobial Activity and Bacterial Survival. Front Immunol. 2022; 13:869692.
Schmitz V, Jo EK, Ochoa MT, Teles RMB. PMID: 35309365; PMCID: PMC8924064.
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PubMed Mentions: Fields:
Translation:
HumansCells
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The cellular architecture of the antimicrobial response network in human leprosy granulomas. Nat Immunol. 2021 07; 22(7):839-850.
Ma F, Hughes TK, Teles RMB, Andrade PR, de Andrade Silva BJ, Plazyo O, Tsoi LC, Do T, Wadsworth MH, Oulee A, Ochoa MT, Sarno EN, Iruela-Arispe ML, Klechevsky E, Bryson B, Shalek AK, Bloom BR, Gudjonsson JE, Pellegrini M, Modlin RL. PMID: 34168371; PMCID: PMC8579511.
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PubMed Mentions:
45 Fields:
Translation:
HumansCells
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Diffuse cutaneous leishmaniasis and HIV co-infection: A case report and review of the literature. J Cutan Pathol. 2021 Jun; 48(6):802-806.
Kassardjian AA, Yim KM, Rabi S, Liang TZ, Kim GH, Ochoa MT, Sattah MV, Ahronowitz IZ. PMID: 33611800.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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Characterization and Outcomes of Patients With Hansen Disease Treated at the Los Angeles County Hospital. JAMA Dermatol. 2019 Oct 01; 155(10):1190-1192.
Chow M, Shue L, Sierro T, Tran K, Vaccaro S, Ochoa MT. PMID: 31389979; PMCID: PMC6686763.
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PubMed Mentions:
1 Fields:
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The cell fate regulator NUPR1 is induced by Mycobacterium leprae via type I interferon in human leprosy. PLoS Negl Trop Dis. 2019 07; 13(7):e0007589.
R Andrade P, Mehta M, Lu J, M B Teles R, Montoya D, O Scumpia P, Nunes Sarno E, Ochoa MT, Ma F, Pellegrini M, Modlin RL. PMID: 31344041; PMCID: PMC6684084.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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IL-1β Induces the Rapid Secretion of the Antimicrobial Protein IL-26 from Th17 Cells. J Immunol. 2019 08 15; 203(4):911-921.
Weiss DI, Ma F, Merleev AA, Maverakis E, Gilliet M, Balin SJ, Bryson BD, Ochoa MT, Pellegrini M, Bloom BR, Modlin RL. PMID: 31235553; PMCID: PMC6684376.
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PubMed Mentions:
14 Fields:
Translation:
HumansCells
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Human antimicrobial cytotoxic T lymphocytes, defined by NK receptors and antimicrobial proteins, kill intracellular bacteria. Sci Immunol. 2018 08 31; 3(26).
Balin SJ, Pellegrini M, Klechevsky E, Won ST, Weiss DI, Choi AW, Hakimian J, Lu J, Ochoa MT, Bloom BR, Lanier LL, Stenger S, Modlin RL. PMID: 30171080; PMCID: PMC6431239.
View in:
PubMed Mentions:
33 Fields:
Translation:
HumansCells
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IL-27 Suppresses Antimicrobial Activity in Human Leprosy. J Invest Dermatol. 2015 Oct; 135(10):2410-2417.
Teles RMB, Kelly-Scumpia KM, Sarno EN, Rea TH, Ochoa MT, Cheng G, Modlin RL. PMID: 26030183; PMCID: PMC4567935.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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T lymphocyte density and distribution in human colorectal mucosa, and inefficiency of current cell isolation protocols. PLoS One. 2015; 10(4):e0122723.
Preza GC, Yang OO, Elliott J, Anton PA, Ochoa MT. PMID: 25856343; PMCID: PMC4391713.
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PubMed Mentions:
22 Fields:
Translation:
HumansCells
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Recognizing and managing the immunologic reactions in leprosy. J Am Acad Dermatol. 2014 Oct; 71(4):795-803.
Kamath S, Vaccaro SA, Rea TH, Ochoa MT. PMID: 24767732.
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PubMed Mentions:
36 Fields:
Translation:
Humans
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Antigen-presenting cell candidates for HIV-1 transmission in human distal colonic mucosa defined by CD207 dendritic cells and CD209 macrophages. AIDS Res Hum Retroviruses. 2014 Mar; 30(3):241-9.
Preza GC, Tanner K, Elliott J, Yang OO, Anton PA, Ochoa MT. PMID: 24134315; PMCID: PMC3938918.
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PubMed Mentions:
27 Fields:
Translation:
HumansCells
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NOD2 triggers an interleukin-32-dependent human dendritic cell program in leprosy. Nat Med. 2012 Mar 25; 18(4):555-63.
Schenk M, Krutzik SR, Sieling PA, Lee DJ, Teles RM, Ochoa MT, Komisopoulou E, Sarno EN, Rea TH, Graeber TG, Kim S, Cheng G, Modlin RL. PMID: 22447076; PMCID: PMC3348859.
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PubMed Mentions:
64 Fields:
Translation:
HumansCells
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Mobile teledermatology: As doctors and patients are increasingly mobile, technology keeps us connected. Skinmed. 2011 Jul-Aug; 9(4):231-8.
Farshidi D, Craft N, Ochoa MT. PMID: 21980708.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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A role for interleukin-5 in promoting increased immunoglobulin M at the site of disease in leprosy. Immunology. 2010 Nov; 131(3):405-14.
Ochoa MT, Teles R, Haas BE, Zaghi D, Li H, Sarno EN, Rea TH, Modlin RL, Lee DJ. PMID: 20561085; PMCID: PMC2996561.
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PubMed Mentions:
7 Fields:
Translation:
HumansCells
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Human immunodeficiency virus and leishmaniasis. J Glob Infect Dis. 2010 Sep; 2(3):248-57.
Ezra N, Ochoa MT, Craft N. PMID: 20927287; PMCID: PMC2946682.
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PubMed Mentions:
24
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Interleukin-4 regulates the expression of CD209 and subsequent uptake of Mycobacterium leprae by Schwann cells in human leprosy. Infect Immun. 2010 Nov; 78(11):4634-43.
Teles RM, Krutzik SR, Ochoa MT, Oliveira RB, Sarno EN, Modlin RL. PMID: 20713631; PMCID: PMC2976321.
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PubMed Mentions:
11 Fields:
Translation:
HumansCells
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New World cutaneous leishmaniasis: current challenges in diagnosis and parenteral treatment. J Am Acad Dermatol. 2011 Mar; 64(3):587-92.
Zaghi D, Panosian C, Gutierrez MA, Gregson A, Taylor E, Ochoa MT. PMID: 20494480.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Integrated pathways for neutrophil recruitment and inflammation in leprosy. J Infect Dis. 2010 Feb 15; 201(4):558-69.
Lee DJ, Li H, Ochoa MT, Tanaka M, Carbone RJ, Damoiseaux R, Burdick A, Sarno EN, Rea TH, Modlin RL. PMID: 20070238; PMCID: PMC2811231.
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PubMed Mentions:
28 Fields:
Translation:
HumansCells
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Divergence of macrophage phagocytic and antimicrobial programs in leprosy. Cell Host Microbe. 2009 Oct 22; 6(4):343-53.
Montoya D, Cruz D, Teles RM, Lee DJ, Ochoa MT, Krutzik SR, Chun R, Schenk M, Zhang X, Ferguson BG, Burdick AE, Sarno EN, Rea TH, Hewison M, Adams JS, Cheng G, Modlin RL. PMID: 19837374; PMCID: PMC2764558.
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PubMed Mentions:
89 Fields:
Translation:
HumansCells
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Dendritic cell vaccination combined with CTLA4 blockade in patients with metastatic melanoma. Clin Cancer Res. 2009 Oct 01; 15(19):6267-76.
Ribas A, Comin-Anduix B, Chmielowski B, Jalil J, de la Rocha P, McCannel TA, Ochoa MT, Seja E, Villanueva A, Oseguera DK, Straatsma BR, Cochran AJ, Glaspy JA, Hui L, Marincola FM, Wang E, Economou JS, Gomez-Navarro J. PMID: 19789309; PMCID: PMC2765061.
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PubMed Mentions:
95 Fields:
Translation:
HumansCellsCTClinical Trials
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Host-derived oxidized phospholipids and HDL regulate innate immunity in human leprosy. J Clin Invest. 2008 Aug; 118(8):2917-28.
Cruz D, Watson AD, Miller CS, Montoya D, Ochoa MT, Sieling PA, Gutierrez MA, Navab M, Reddy ST, Witztum JL, Fogelman AM, Rea TH, Eisenberg D, Berliner J, Modlin RL. PMID: 18636118; PMCID: PMC2467381.
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PubMed Mentions:
82 Fields:
Translation:
HumansCells
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"Dermal dendritic cells" comprise two distinct populations: CD1+ dendritic cells and CD209+ macrophages. J Invest Dermatol. 2008 Sep; 128(9):2225-31.
Ochoa MT, Loncaric A, Krutzik SR, Becker TC, Modlin RL. PMID: 18337829; PMCID: PMC2682223.
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PubMed Mentions:
50 Fields:
Translation:
HumansCells
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LILRA2 activation inhibits dendritic cell differentiation and antigen presentation to T cells. J Immunol. 2007 Dec 15; 179(12):8128-36.
Lee DJ, Sieling PA, Ochoa MT, Krutzik SR, Guo B, Hernandez M, Rea TH, Cheng G, Colonna M, Modlin RL. PMID: 18056355; PMCID: PMC2650749.
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PubMed Mentions:
30 Fields:
Translation:
HumansCells
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Activation of human CD4+ T cells by targeting MHC class II epitopes to endosomal compartments using human CD1 tail sequences. Immunology. 2007 Dec; 122(4):522-31.
Niazi KR, Ochoa MT, Sieling PA, Rooke NE, Peter AK, Mollahan P, Dickey M, Rabizadeh S, Rea TH, Modlin RL. PMID: 17635609; PMCID: PMC2266034.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Regulation of human T-cell homing receptor expression in cutaneous bacterial infection. Immunology. 2007 Apr; 120(4):518-25.
Sieling PA, Legaspi A, Ochoa MT, Rea TH, Modlin RL. PMID: 17343614; PMCID: PMC2265905.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Functional characterization of a T-cell receptor BV6+ T-cell clone derived from a leprosy lesion. Immunology. 2007 Mar; 120(3):354-61.
Sabet S, Ochoa MT, Sieling PA, Rea TH, Modlin RL. PMID: 17140401; PMCID: PMC2265884.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Macrophages acquire neutrophil granules for antimicrobial activity against intracellular pathogens. J Immunol. 2006 Aug 01; 177(3):1864-71.
Tan BH, Meinken C, Bastian M, Bruns H, Legaspi A, Ochoa MT, Krutzik SR, Bloom BR, Ganz T, Modlin RL, Stenger S. PMID: 16849498.
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PubMed Mentions:
97 Fields:
Translation:
HumansCells
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TLR activation of Langerhans cell-like dendritic cells triggers an antiviral immune response. J Immunol. 2006 Jul 01; 177(1):298-305.
Renn CN, Sanchez DJ, Ochoa MT, Legaspi AJ, Oh CK, Liu PT, Krutzik SR, Sieling PA, Cheng G, Modlin RL. PMID: 16785525.
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PubMed Mentions:
41 Fields:
Translation:
HumansCells
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Human dendritic cell expression of HLA-DO is subset specific and regulated by maturation. J Immunol. 2006 Mar 15; 176(6):3536-47.
Hornell TM, Burster T, Jahnsen FL, Pashine A, Ochoa MT, Harding JJ, Macaubas C, Lee AW, Modlin RL, Mellins ED. PMID: 16517722.
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PubMed Mentions:
32 Fields:
Translation:
HumansCells
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Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science. 2006 Mar 24; 311(5768):1770-3.
Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, Ochoa MT, Schauber J, Wu K, Meinken C, Kamen DL, Wagner M, Bals R, Steinmeyer A, Zügel U, Gallo RL, Eisenberg D, Hewison M, Hollis BW, Adams JS, Bloom BR, Modlin RL. PMID: 16497887.
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PubMed Mentions:
1451 Fields:
Translation:
HumansCells
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TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells. Nat Med. 2005 Jun; 11(6):653-60.
Krutzik SR, Tan B, Li H, Ochoa MT, Liu PT, Sharfstein SE, Graeber TG, Sieling PA, Liu YJ, Rea TH, Bloom BR, Modlin RL. PMID: 15880118; PMCID: PMC1409736.
View in:
PubMed Mentions:
154 Fields:
Translation:
HumansCells
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Mohs' micrographic surgery of a proliferating trichilemmal tumor in a young black man. Dermatol Surg. 2005 Mar; 31(3):359-63.
Tierney E, Ochoa MT, Rudkin G, Soriano TT. PMID: 15841643.
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PubMed Mentions:
8 Fields:
Translation:
Humans
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Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells. J Clin Invest. 2004 Mar; 113(5):701-8.
Hunger RE, Sieling PA, Ochoa MT, Sugaya M, Burdick AE, Rea TH, Brennan PJ, Belisle JT, Blauvelt A, Porcelli SA, Modlin RL. PMID: 14991068; PMCID: PMC351318.
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PubMed Mentions:
102 Fields:
Translation:
HumansCells
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Use of genetic profiling in leprosy to discriminate clinical forms of the disease. Science. 2003 Sep 12; 301(5639):1527-30.
Bleharski JR, Li H, Meinken C, Graeber TG, Ochoa MT, Yamamura M, Burdick A, Sarno EN, Wagner M, Röllinghoff M, Rea TH, Colonna M, Stenger S, Bloom BR, Eisenberg D, Modlin RL. PMID: 12970564.
View in:
PubMed Mentions:
72 Fields:
Translation:
HumansCells
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Activation and regulation of Toll-like receptors 2 and 1 in human leprosy. Nat Med. 2003 May; 9(5):525-32.
Krutzik SR, Ochoa MT, Sieling PA, Uematsu S, Ng YW, Legaspi A, Liu PT, Cole ST, Godowski PJ, Maeda Y, Sarno EN, Norgard MV, Brennan PJ, Akira S, Rea TH, Modlin RL. PMID: 12692544.
View in:
PubMed Mentions:
103 Fields:
Translation:
HumansAnimals
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Expression of Toll-like receptor 2 on human Schwann cells: a mechanism of nerve damage in leprosy. Infect Immun. 2003 Mar; 71(3):1427-33.
Oliveira RB, Ochoa MT, Sieling PA, Rea TH, Rambukkana A, Sarno EN, Modlin RL. PMID: 12595460; PMCID: PMC148832.
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PubMed Mentions:
42 Fields:
Translation:
HumansCells
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Distribution of Toll-like receptor 1 and Toll-like receptor 2 in human lymphoid tissue. Immunology. 2003 Jan; 108(1):10-5.
Ochoa MT, Legaspi AJ, Hatziris Z, Godowski PJ, Modlin RL, Sieling PA. PMID: 12519297; PMCID: PMC1782859.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses. J Immunol. 2002 Aug 01; 169(3):1535-41.
Kim J, Ochoa MT, Krutzik SR, Takeuchi O, Uematsu S, Legaspi AJ, Brightbill HD, Holland D, Cunliffe WJ, Akira S, Sieling PA, Godowski PJ, Modlin RL. PMID: 12133981; PMCID: PMC4636337.
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PubMed Mentions:
167 Fields:
Translation:
HumansAnimalsCells
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Signaling lymphocytic activation molecule expression and regulation in human intracellular infection correlate with Th1 cytokine patterns. J Immunol. 2001 Nov 15; 167(10):5719-24.
García VE, Quiroga MF, Ochoa MT, Ochoa L, Pasquinelli V, Fainboim L, Olivares LM, Valdez R, Sordelli DO, Aversa G, Modlin RL, Sieling PA. PMID: 11698444.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Treatment failure in children in a randomized clinical trial with 10 and 20 days of meglumine antimonate for cutaneous leishmaniasis due to Leishmania viannia species. Am J Trop Med Hyg. 2001 Mar-Apr; 64(3-4):187-93.
Palacios R, Osorio LE, Grajalew LF, Ochoa MT. PMID: 11442216.
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PubMed Mentions:
40 Fields:
Translation:
HumansAnimalsCTClinical Trials
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Induction of direct antimicrobial activity through mammalian toll-like receptors. Science. 2001 Feb 23; 291(5508):1544-7.
Thoma-Uszynski S, Stenger S, Takeuchi O, Ochoa MT, Engele M, Sieling PA, Barnes PF, Rollinghoff M, Bolcskei PL, Wagner M, Akira S, Norgard MV, Belisle JT, Godowski PJ, Bloom BR, Modlin RL. PMID: 11222859.
View in:
PubMed Mentions:
234 Fields:
Translation:
HumansAnimalsCells
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T-cell release of granulysin contributes to host defense in leprosy. Nat Med. 2001 Feb; 7(2):174-9.
Ochoa MT, Stenger S, Sieling PA, Thoma-Uszynski S, Sabet S, Cho S, Krensky AM, Rollinghoff M, Nunes Sarno E, Burdick AE, Rea TH, Modlin RL. PMID: 11175847.
View in:
PubMed Mentions:
52 Fields:
Translation:
HumansCells
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Role of granulysin in immunity to leprosy. Lepr Rev. 2000 Dec; 71 Suppl:S115; discussion S115-6.
Ochoa MT, Thoma-Uszynski S, Sieling PA, Sabet S, Cho S, Krensky AM, Burdick A, Rea TH, Modlin RL. PMID: 11201866.
View in:
PubMed Mentions:
3 Fields:
Translation:
Humans
-
Activation of toll-like receptor 2 on human dendritic cells triggers induction of IL-12, but not IL-10. J Immunol. 2000 Oct 01; 165(7):3804-10.
Thoma-Uszynski S, Kiertscher SM, Ochoa MT, Bouis DA, Norgard MV, Miyake K, Godowski PJ, Roth MD, Modlin RL. PMID: 11034386.
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PubMed Mentions:
55 Fields:
Translation:
HumansCells
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Evidence for human CD4+ T cells in the CD1-restricted repertoire: derivation of mycobacteria-reactive T cells from leprosy lesions. J Immunol. 2000 May 01; 164(9):4790-6.
Sieling PA, Ochoa MT, Jullien D, Leslie DS, Sabet S, Rosat JP, Burdick AE, Rea TH, Brenner MB, Porcelli SA, Modlin RL. PMID: 10779786.
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PubMed Mentions:
26 Fields:
Translation:
HumansCells
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Positive IgG Western blot for Borrelia burgdorferi in Colombia. Mem Inst Oswaldo Cruz. 1999 Jul-Aug; 94(4):499-503.
Palacios R, Osorio LE, Giraldo LE, Torres AJ, Philipp MT, Ochoa MT. PMID: 10446009.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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IL-18 promotes type 1 cytokine production from NK cells and T cells in human intracellular infection. J Immunol. 1999 May 15; 162(10):6114-21.
García VE, Uyemura K, Sieling PA, Ochoa MT, Morita CT, Okamura H, Kurimoto M, Rea TH, Modlin RL. PMID: 10229854.
View in:
PubMed Mentions:
36 Fields:
Translation:
HumansCells
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Mucosal leishmaniasis due to Leishmania (Viannia) panamensis in Colombia: clinical characteristics. Am J Trop Med Hyg. 1998 Jul; 59(1):49-52.
Osorio LE, Castillo CM, Ochoa MT. PMID: 9684627.
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PubMed Mentions:
35 Fields:
Translation:
HumansAnimals
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Treatment of cutaneous leishmaniasis in Colombia with dapsone. Lancet. 1998 Feb 14; 351(9101):498-9.
Osorio LE, Palacios R, Chica ME, Ochoa MT. PMID: 9482449.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansCTClinical Trials
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Changes in expression of signal transduction proteins in T lymphocytes of patients with leprosy. Infect Immun. 1998 Feb; 66(2):499-504.
Zea AH, Ochoa MT, Ghosh P, Longo DL, Alvord WG, Valderrama L, Falabella R, Harvey LK, Saravia N, Moreno LH, Ochoa AC. PMID: 9453602; PMCID: PMC107934.
View in:
PubMed Mentions:
25 Fields:
Translation:
HumansCells
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Lepromatous and tuberculoid leprosy: clinical presentation and cytokine responses. Int J Dermatol. 1996 Nov; 35(11):786-90.
Ochoa MT, Valderrama L, Ochoa A, Zea A, Escobar CE, Moreno LH, Falabella R. PMID: 8915730.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansCells
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A yeast-derived antigen from Paracoccidioides brasiliensis useful for serologic testing. Sabouraudia. 1985 Feb; 23(1):23-9.
Restrepo A, Cano LE, Ochoa MT. PMID: 3922069.
View in:
PubMed Mentions:
4 Fields:
Translation:
Animals