Lucas J Osborn, PhD

Title(s)Assistant Professor Of Clinical Pathology
SchoolKeck School of Medicine of Usc
Address1200 N. State Street
University Park Campus
Los Angeles CA 90033
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    Collapse Biography 
    Collapse Education and Training
    Children's Hospital Los Angeles, Los Angeles, CA, USAMedical and Public Health Microbiology Fellowship
    Cleveland Clinic Lerner College of Medicine | Case Western Reserve University, Cleveland, OH, USAPhDMolecular Medicine
    Michigan State University, East Lansing, MI, USABSBiomedical Laboratory Science

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    Collapse Overview
    Dr. Osborn is the Director of Microbiology at Keck Medical Center of USC and an Assistant Professor of Clinical Pathology at Keck School of Medicine of USC in Los Angeles, California, USA. Dr. Osborn earned his PhD in Molecular Medicine at Cleveland Clinic Lerner College of Medicine of Case Western Reserve University and completed a postdoctoral fellowship in Medical and Public Health Microbiology at Children's Hospital Los Angeles. Dr. Osborn’s research interests include applications of machine learning in clinical microbiology, reducing the turnaround time of infectious disease diagnostics, next generation sequencing, and diagnostic stewardship. Dr. Osborn is a Diplomate of the American Board of Medical Microbiology.

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Development of an automated amplicon-based next-generation sequencing pipeline for rapid detection of bacteria and fungi directly from clinical specimens. J Clin Microbiol. 2024 May 08; 62(5):e0174923. Osborn LJ, Fissel J, Gomez S, Mestas J, Flores-Vazquez J, Lee J, Hakimjavadi H, Costales C, Dien Bard J. PMID: 38624235; PMCID: PMC11077995.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Metaorganismal choline metabolism shapes olfactory perception. J Biol Chem. 2023 11; 299(11):105299. Massey WJ, Kay KE, Jaramillo TC, Horak AJ, Cao S, Osborn LJ, Banerjee R, Mrdjen M, Hamoudi MK, Silver DJ, Burrows AC, Brown AL, Reizes O, Lathia JD, Wang Z, Hazen SL, Brown JM. PMID: 37777156; PMCID: PMC10630631.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    3. Strain dropouts reveal interactions that govern the metabolic output of the gut microbiome. Cell. 2023 06 22; 186(13):2839-2852.e21. Wang M, Osborn LJ, Jain S, Meng X, Weakley A, Yan J, Massey WJ, Varadharajan V, Horak A, Banerjee R, Allende DS, Chan ER, Hajjar AM, Wang Z, Dimas A, Zhao A, Nagashima K, Cheng AG, Higginbottom S, Hazen SL, Brown JM, Fischbach MA. PMID: 37352836; PMCID: PMC10299816.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    4. Clinical utility of SARS-CoV-2 subgenomic RT-PCR in a pediatric quaternary care setting. J Clin Virol. 2023 07; 164:105494. Osborn LJ, Chen PY, Flores-Vazquez J, Mestas J, Salas E, Glucoft M, Smit MA, Costales C, Dien Bard J. PMID: 37210881; PMCID: PMC10191725.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    5. A gut microbial metabolite of dietary polyphenols reverses obesity-driven hepatic steatosis. Proc Natl Acad Sci U S A. 2022 11 29; 119(48):e2202934119. Osborn LJ, Schultz K, Massey W, DeLucia B, Choucair I, Varadharajan V, Banerjee R, Fung K, Horak AJ, Orabi D, Nemet I, Nagy LE, Wang Z, Allende DS, Willard BB, Sangwan N, Hajjar AM, McDonald C, Ahern PP, Hazen SL, Brown JM, Claesen J. PMID: 36417437; PMCID: PMC9860326.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    6. Monkeypox: Clinical Considerations, Epidemiology, and Laboratory Diagnostics. Clin Microbiol Newsl. 2022 Nov 15; 44(22):199-208. Osborn LJ, Villarreal D, Wald-Dickler N, Bard JD. PMID: 36438980; PMCID: PMC9674185.
      View in: PubMed   Mentions: 3  
    7. Flavin-Containing Monooxygenase 3 (FMO3) Is Critical for Dioxin-Induced Reorganization of the Gut Microbiome and Host Insulin Sensitivity. Metabolites. 2022 Apr 18; 12(4). Massey W, Osborn LJ, Banerjee R, Horak A, Fung KK, Orabi D, Chan ER, Sangwan N, Wang Z, Brown JM. PMID: 35448550; PMCID: PMC9029240.
      View in: PubMed   Mentions: 4  
    8. A 3D-printable device allowing fast and reproducible longitudinal preparation of mouse intestines. Animal Model Exp Med. 2022 04; 5(2):189-196. DeLucia B, Samorezov S, Zangara MT, Markley RL, Osborn LJ, Schultz KB, McDonald C, Claesen J. PMID: 35415968; PMCID: PMC9043725.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    9. Multicenter Evaluation of a Gradient Diffusion Method for Antimicrobial Susceptibility Testing of Helicobacter pylori. Microbiol Spectr. 2022 04 27; 10(2):e0211121. Shakir SM, Otiso J, Keller G, Heule HV, Osborn LJ, Cole N, Schuetz AN, Richter SS, Couturier MR. PMID: 35254119; PMCID: PMC9045198.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    10. Gut microbial trimethylamine is elevated in alcohol-associated hepatitis and contributes to ethanol-induced liver injury in mice. Elife. 2022 01 27; 11. Helsley RN, Miyata T, Kadam A, Varadharajan V, Sangwan N, Huang EC, Banerjee R, Brown AL, Fung KK, Massey WJ, Neumann C, Orabi D, Osborn LJ, Schugar RC, McMullen MR, Bellar A, Poulsen KL, Kim A, Pathak V, Mrdjen M, Anderson JT, Willard B, McClain CJ, Mitchell M, McCullough AJ, Radaeva S, Barton B, Szabo G, Dasarathy S, Garcia-Garcia JC, Rotroff DM, Allende DS, Wang Z, Hazen SL, Nagy LE, Brown JM. PMID: 35084335; PMCID: PMC8853661.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    11. Gut microbe-targeted choline trimethylamine lyase inhibition improves obesity via rewiring of host circadian rhythms. Elife. 2022 01 24; 11. Schugar RC, Gliniak CM, Osborn LJ, Massey W, Sangwan N, Horak A, Banerjee R, Orabi D, Helsley RN, Brown AL, Burrows A, Finney C, Fung KK, Allen FM, Ferguson D, Gromovsky AD, Neumann C, Cook K, McMillan A, Buffa JA, Anderson JT, Mehrabian M, Goudarzi M, Willard B, Mak TD, Armstrong AR, Swanson G, Keshavarzian A, Garcia-Garcia JC, Wang Z, Lusis AJ, Hazen SL, Brown JM. PMID: 35072627; PMCID: PMC8813054.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    12. The Nutritional Supplement L-Alpha Glycerylphosphorylcholine Promotes Atherosclerosis. Int J Mol Sci. 2021 Dec 15; 22(24). Wang Z, Hazen J, Jia X, Org E, Zhao Y, Osborn LJ, Nimer N, Buffa J, Culley MK, Krajcik D, van den Born BH, Zwinderman K, Levison BS, Nieuwdorp M, Lusis AJ, DiDonato JA, Hazen SL. PMID: 34948275; PMCID: PMC8708068.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    13. Microbial Flavonoid Metabolism: A Cardiometabolic Disease Perspective. Annu Rev Nutr. 2021 10 11; 41:433-454. Osborn LJ, Claesen J, Brown JM. PMID: 34633856.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    14. A Single Human-Relevant Fast Food Meal Rapidly Reorganizes Metabolomic and Transcriptomic Signatures in a Gut Microbiota-Dependent Manner. Immunometabolism. 2021; 3(4). Osborn LJ, Orabi D, Goudzari M, Sangwan N, Banerjee R, Brown AL, Kadam A, Gromovsky AD, Linga P, Cresci GAM, Mak TD, Willard BB, Claesen J, Brown JM. PMID: 34804604; PMCID: PMC8601658.
      View in: PubMed   Mentions: 2  
    15. Identification of essential genes for Escherichia coli aryl polyene biosynthesis and function in biofilm formation. NPJ Biofilms Microbiomes. 2021 07 02; 7(1):56. Johnston I, Osborn LJ, Markley RL, McManus EA, Kadam A, Schultz KB, Nagajothi N, Ahern PP, Brown JM, Claesen J. PMID: 34215744; PMCID: PMC8253772.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    16. A surgical method for continuous intraportal infusion of gut microbial metabolites in mice. JCI Insight. 2021 05 10; 6(9). Orabi D, Osborn LJ, Fung K, Massey W, Horak AJ, Aucejo F, Choucair I, DeLucia B, Wang Z, Claesen J, Brown JM. PMID: 33986195; PMCID: PMC8262340.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    17. Simultaneous Measurement of Urinary Trimethylamine (TMA) and Trimethylamine N-Oxide (TMAO) by Liquid Chromatography-Mass Spectrometry. Molecules. 2020 Apr 17; 25(8). Jia X, Osborn LJ, Wang Z. PMID: 32316639; PMCID: PMC7222018.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    18. Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease. Elife. 2019 10 17; 8. Helsley RN, Varadharajan V, Brown AL, Gromovsky AD, Schugar RC, Ramachandiran I, Fung K, Kabbany MN, Banerjee R, Neumann CK, Finney C, Pathak P, Orabi D, Osborn LJ, Massey W, Zhang R, Kadam A, Sansbury BE, Pan C, Sacks J, Lee RG, Crooke RM, Graham MJ, Lemieux ME, Gogonea V, Kirwan JP, Allende DS, Civelek M, Fox PL, Rudel LL, Lusis AJ, Spite M, Brown JM. PMID: 31621579; PMCID: PMC6850774.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
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    NIH Funding Acknowledgment: Important - All publications resulting from the utilization of SC CTSI resources are required to credit the SC CTSI grant by including the NIH funding acknowledgment and must comply with the NIH Public Access Policy.

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