Loading...

Lori Walker

Title(s)Clinical Assistant Professor of Family Medicine (Practitioner)
SchoolKeck School of Medicine of USC
Phone+1 213 740 9355
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Biochemical Markers of Progressive Heart Disease
    NIH/NHLBI R21HL104352Apr 1, 2011 - Dec 31, 2012
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Chi C, Leonard A, Knight WE, Beussman KM, Zhao Y, Cao Y, Londono P, Aune E, Trembley MA, Small EM, Jeong MY, Walker LA, Xu H, Sniadecki NJ, Taylor MR, Buttrick PM, Song K. LAMP-2B regulates human cardiomyocyte function by mediating autophagosome-lysosome fusion. Proc Natl Acad Sci U S A. 2018 Dec 24. PMID: 30584088.
      View in: PubMed
    2. Johnson-Sasso CP, Tompkins C, Kao DP, Walker LA. Marijuana use and short-term outcomes in patients hospitalized for acute myocardial infarction. PLoS One. 2018; 13(7):e0199705. PMID: 29995914.
      View in: PubMed
    3. Scalzo RL, Knaub LA, Hull SE, Keller AC, Hunter K, Walker LA, Reusch JEB. Glucagon-like peptide-1 receptor antagonism impairs basal exercise capacity and vascular adaptation to aerobic exercise training in rats. Physiol Rep. 2018 Jul; 6(13):e13754. PMID: 29984491.
      View in: PubMed
    4. Bruns DR, Walker LA. Exercise and Pharmacology as Medicine for Cardiovascular Diseases: From Bench to Bedside and Back. Exerc Sport Sci Rev. 2018 01; 46(1):2-3. PMID: 28902725.
      View in: PubMed
    5. Tyagi S, Beqollari D, Lee CS, Walker LA, Bannister RA. Semi-automated Analysis of Mouse Skeletal Muscle Morphology and Fiber-type Composition. J Vis Exp. 2017 08 31; (126). PMID: 28892032.
      View in: PubMed
    6. Bruns DR, Ghincea AR, Ghincea CV, Azuma YT, Watson PA, Autieri MV, Walker LA. Interleukin-19 is cardioprotective in dominant negative cyclic adenosine monophosphate response-element binding protein-mediated heart failure in a sex-specific manner. World J Cardiol. 2017 Aug 26; 9(8):673-684. PMID: 28932356.
      View in: PubMed
    7. Bartman CM, Oyama Y, Brodsky K, Khailova L, Walker L, Koeppen M, Eckle T. Intense light-elicited upregulation of miR-21 facilitates glycolysis and cardioprotection through Per2-dependent mechanisms. PLoS One. 2017; 12(4):e0176243. PMID: 28448534.
      View in: PubMed
    8. Horita H, Wysoczynski CL, Walker LA, Moulton KS, Li M, Ostriker A, Tucker R, McKinsey TA, Churchill ME, Nemenoff RA, Weiser-Evans MC. Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation. Nat Commun. 2016 Mar 04; 7:10830. PMID: 26940659.
      View in: PubMed
    9. Keller AC, Knaub LA, McClatchey PM, Connon CA, Bouchard R, Miller MW, Geary KE, Walker LA, Klemm DJ, Reusch JE. Differential Mitochondrial Adaptation in Primary Vascular Smooth Muscle Cells from a Diabetic Rat Model. Oxid Med Cell Longev. 2016; 2016:8524267. PMID: 27034743.
      View in: PubMed
    10. Bruns DR, Buttrick PM, Walker LA. Genetic ablation of interleukin-18 does not attenuate hypobaric hypoxia-induced right ventricular hypertrophy. Am J Physiol Lung Cell Mol Physiol. 2016 Mar 15; 310(6):L542-50. PMID: 26747780; PMCID: PMC4796262 [Available on 03/15/17].
    11. Zhao Y, Londono P, Cao Y, Sharpe EJ, Proenza C, O'Rourke R, Jones KL, Jeong MY, Walker LA, Buttrick PM, McKinsey TA, Song K. High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling. Nat Commun. 2015 Sep 10; 6:8243. PMID: 26354680; PMCID: PMC4579788.
    12. Seo SW, Koeppen M, Bonney S, Gobel M, Thayer M, Harter PN, Ravid K, Eltzschig HK, Mittelbronn M, Walker L, Eckle T. Differential Tissue-Specific Function of Adora2b in Cardioprotection. J Immunol. 2015 Aug 15; 195(4):1732-43. PMID: 26136425; PMCID: PMC4576932.
    13. Bruns DR, Brown RD, Stenmark KR, Buttrick PM, Walker LA. Mitochondrial integrity in a neonatal bovine model of right ventricular dysfunction. Am J Physiol Lung Cell Mol Physiol. 2015 Jan 15; 308(2):L158-67. PMID: 25416385; PMCID: PMC4338944.
    14. Sutliff RL, Walp ER, Kim YH, Walker LA, El-Ali AM, Ma J, Bonsall R, Ramosevac S, Eaton DC, Verlander JW, Hansen L, Gleason RL, Pham TD, Hong S, Pech V, Wall SM. Contractile force is enhanced in Aortas from pendrin null mice due to stimulation of angiotensin II-dependent signaling. PLoS One. 2014; 9(8):e105101. PMID: 25148130.
      View in: PubMed
    15. Kwartler CS, Chen J, Thakur D, Li S, Baskin K, Wang S, Wang ZV, Walker L, Hill JA, Epstein HF, Taegtmeyer H, Milewicz DM. Overexpression of smooth muscle myosin heavy chain leads to activation of the unfolded protein response and autophagic turnover of thick filament-associated proteins in vascular smooth muscle cells. J Biol Chem. 2014 May 16; 289(20):14075-88. PMID: 24711452; PMCID: PMC4022877.
    16. Thoemmes SF, Stutzke CA, Du Y, Browning MD, Buttrick PM, Walker LA. Characterization and validation of new tools for measuring site-specific cardiac troponin I phosphorylation. J Immunol Methods. 2014 Jan 31; 403(1-2):66-71. PMID: 24291343; PMCID: PMC3945064.
    17. Bonney S, Kominsky D, Brodsky K, Eltzschig H, Walker L, Eckle T. Cardiac Per2 functions as novel link between fatty acid metabolism and myocardial inflammation during ischemia and reperfusion injury of the heart. PLoS One. 2013; 8(8):e71493. PMID: 23977055.
      View in: PubMed
    18. Walker LA, Fullerton DA, Buttrick PM. Contractile protein phosphorylation predicts human heart disease phenotypes. Am J Physiol Heart Circ Physiol. 2013 Jun 15; 304(12):H1644-50. PMID: 23564307; PMCID: PMC3680767.
    19. Walker LA, Buttrick PM. The right ventricle: biologic insights and response to disease: updated. Curr Cardiol Rev. 2013 Feb 01; 9(1):73-81. PMID: 23092273; PMCID: PMC3584309.
    20. Bonney S, Hughes K, Harter PN, Mittelbronn M, Walker L, Eckle T. Cardiac period 2 in myocardial ischemia: clinical implications of a light dependent protein. Int J Biochem Cell Biol. 2013 Mar; 45(3):667-71. PMID: 23291353; PMCID: PMC3761885.
    21. Lewandowski ED, Fischer SK, Fasano M, Banke NH, Walker LA, Huqi A, Wang X, Lopaschuk GD, O'Donnell JM. Acute liver carnitine palmitoyltransferase I overexpression recapitulates reduced palmitate oxidation of cardiac hypertrophy. Circ Res. 2013 Jan 04; 112(1):57-65. PMID: 22982985; PMCID: PMC3537878.
    22. Eckle T, Hartmann K, Bonney S, Reithel S, Mittelbronn M, Walker LA, Lowes BD, Han J, Borchers CH, Buttrick PM, Kominsky DJ, Colgan SP, Eltzschig HK. Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia. Nat Med. 2012 Apr 15; 18(5):774-82. PMID: 22504483; PMCID: PMC3378044.
    23. Vitello AM, Du Y, Buttrick PM, Walker LA. Serendipitous discovery of a novel protein signaling mechanism in heart failure. Biochem Biophys Res Commun. 2012 May 11; 421(3):431-5. PMID: 22503978; PMCID: PMC3351564.
    24. Cavasin MA, Demos-Davies K, Horn TR, Walker LA, Lemon DD, Birdsey N, Weiser-Evans MC, Harral J, Irwin DC, Anwar A, Yeager ME, Li M, Watson PA, Nemenoff RA, Buttrick PM, Stenmark KR, McKinsey TA. Selective class I histone deacetylase inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an antiproliferative mechanism. Circ Res. 2012 Mar 02; 110(5):739-48. PMID: 22282194; PMCID: PMC3682822.
    25. Port JD, Walker LA, Polk J, Nunley K, Buttrick PM, Sucharov CC. Temporal expression of miRNAs and mRNAs in a mouse model of myocardial infarction. Physiol Genomics. 2011 Oct 06; 43(19):1087-95. PMID: 21771878; PMCID: PMC3217325.
    26. Walker LA, Walker JS, Glazier A, Brown DR, Stenmark KR, Buttrick PM. Biochemical and myofilament responses of the right ventricle to severe pulmonary hypertension. Am J Physiol Heart Circ Physiol. 2011 Sep; 301(3):H832-40. PMID: 21622821; PMCID: PMC3191097.
    27. Ambardekar AV, Walker JS, Walker LA, Cleveland JC, Lowes BD, Buttrick PM. Incomplete recovery of myocyte contractile function despite improvement of myocardial architecture with left ventricular assist device support. Circ Heart Fail. 2011 Jul; 4(4):425-32. PMID: 21540356; PMCID: PMC3407673.
    28. Walker JS, Walker LA, Margulies K, Buttrick P, de Tombe P. Protein kinase A changes calcium sensitivity but not crossbridge kinetics in human cardiac myofibrils. Am J Physiol Heart Circ Physiol. 2011 Jul; 301(1):H138-46. PMID: 21498779; PMCID: PMC3129926.
    29. Walker LA, Medway AM, Walker JS, Cleveland JC, Buttrick PM. Tissue procurement strategies affect the protein biochemistry of human heart samples. J Muscle Res Cell Motil. 2011 Mar; 31(5-6):309-14. PMID: 21184256.
      View in: PubMed
    30. Boontje NM, Merkus D, Zaremba R, Versteilen A, de Waard MC, Mearini G, de Beer VJ, Carrier L, Walker LA, Niessen HW, Dobrev D, Stienen GJ, Duncker DJ, van der Velden J. Enhanced myofilament responsiveness upon ß-adrenergic stimulation in post-infarct remodeled myocardium. J Mol Cell Cardiol. 2011 Mar; 50(3):487-99. PMID: 21156182.
      View in: PubMed
    31. Walker LA, Walker JS, Ambler SK, Buttrick PM. Stage-specific changes in myofilament protein phosphorylation following myocardial infarction in mice. J Mol Cell Cardiol. 2010 Jun; 48(6):1180-6. PMID: 19799909; PMCID: PMC4447307.
    32. Duncker DJ, Boontje NM, Merkus D, Versteilen A, Krysiak J, Mearini G, El-Armouche A, de Beer VJ, Lamers JM, Carrier L, Walker LA, Linke WA, Stienen GJ, van der Velden J. Prevention of myofilament dysfunction by beta-blocker therapy in postinfarct remodeling. Circ Heart Fail. 2009 May; 2(3):233-42. PMID: 19808345.
      View in: PubMed
    33. Luckey SW, Walker LA, Smyth T, Mansoori J, Messmer-Kratzsch A, Rosenzweig A, Olson EN, Leinwand LA. The role of Akt/GSK-3beta signaling in familial hypertrophic cardiomyopathy. J Mol Cell Cardiol. 2009 May; 46(5):739-47. PMID: 19233194; PMCID: PMC2701230.
    34. Walker LA, Buttrick PM. The right ventricle: biologic insights and response to disease. Curr Cardiol Rev. 2009 Jan; 5(1):22-8. PMID: 20066144; PMCID: PMC2803284.
    35. Scruggs SB, Hinken AC, Thawornkaiwong A, Robbins J, Walker LA, de Tombe PP, Geenen DL, Buttrick PM, Solaro RJ. Ablation of ventricular myosin regulatory light chain phosphorylation in mice causes cardiac dysfunction in situ and affects neighboring myofilament protein phosphorylation. J Biol Chem. 2009 Feb 20; 284(8):5097-106. PMID: 19106098; PMCID: PMC2643522.
    36. Koshman YE, Waters SB, Walker LA, Los T, de Tombe P, Goldspink PH, Russell B. Delivery and visualization of proteins conjugated to quantum dots in cardiac myocytes. J Mol Cell Cardiol. 2008 Dec; 45(6):853-6. PMID: 18835396; PMCID: PMC2639397.
    37. Homma N, Nagaoka T, Karoor V, Imamura M, Taraseviciene-Stewart L, Walker LA, Fagan KA, McMurtry IF, Oka M. Involvement of RhoA/Rho kinase signaling in protection against monocrotaline-induced pulmonary hypertension in pneumonectomized rats by dehydroepiandrosterone. Am J Physiol Lung Cell Mol Physiol. 2008 Jul; 295(1):L71-8. PMID: 18469113; PMCID: PMC2494797.
    38. Lamberts RR, Hamdani N, Soekhoe TW, Boontje NM, Zaremba R, Walker LA, de Tombe PP, van der Velden J, Stienen GJ. Frequency-dependent myofilament Ca2+ desensitization in failing rat myocardium. J Physiol. 2007 Jul 15; 582(Pt 2):695-709. PMID: 17478529; PMCID: PMC2075316.
    39. Martin AF, Bhatti S, Pyne-Geithman GJ, Farjah M, Manaves V, Walker L, Franks R, Strauch AR, Paul RJ. Expression and function of COOH-terminal myosin heavy chain isoforms in mouse smooth muscle. Am J Physiol Cell Physiol. 2007 Jul; 293(1):C238-45. PMID: 17392380.
      View in: PubMed
    40. Dias FA, Walker LA, Arteaga GM, Walker JS, Vijayan K, Peña JR, Ke Y, Fogaca RT, Sanbe A, Robbins J, Wolska BM. The effect of myosin regulatory light chain phosphorylation on the frequency-dependent regulation of cardiac function. J Mol Cell Cardiol. 2006 Aug; 41(2):330-9. PMID: 16806259.
      View in: PubMed
    41. Belin RJ, Sumandea MP, Kobayashi T, Walker LA, Rundell VL, Urboniene D, Yuzhakova M, Ruch SH, Geenen DL, Solaro RJ, de Tombe PP. Left ventricular myofilament dysfunction in rat experimental hypertrophy and congestive heart failure. Am J Physiol Heart Circ Physiol. 2006 Nov; 291(5):H2344-53. PMID: 16815982.
      View in: PubMed
    42. Scruggs SB, Walker LA, Lyu T, Geenen DL, Solaro RJ, Buttrick PM, Goldspink PH. Partial replacement of cardiac troponin I with a non-phosphorylatable mutant at serines 43/45 attenuates the contractile dysfunction associated with PKCepsilon phosphorylation. J Mol Cell Cardiol. 2006 Apr; 40(4):465-73. PMID: 16445938.
      View in: PubMed
    43. Jweied EE, McKinney RD, Walker LA, Brodsky I, Geha AS, Massad MG, Buttrick PM, de Tombe PP. Depressed cardiac myofilament function in human diabetes mellitus. Am J Physiol Heart Circ Physiol. 2005 Dec; 289(6):H2478-83. PMID: 16085678.
      View in: PubMed
    44. Urboniene D, Dias FA, Peña JR, Walker LA, Solaro RJ, Wolska BM. Expression of slow skeletal troponin I in adult mouse heart helps to maintain the left ventricular systolic function during respiratory hypercapnia. Circ Res. 2005 Jul 08; 97(1):70-7. PMID: 15961720.
      View in: PubMed
    45. Kobayashi T, Yang X, Walker LA, Van Breemen RB, Solaro RJ. A non-equilibrium isoelectric focusing method to determine states of phosphorylation of cardiac troponin I: identification of Ser-23 and Ser-24 as significant sites of phosphorylation by protein kinase C. J Mol Cell Cardiol. 2005 Jan; 38(1):213-8. PMID: 15623438.
      View in: PubMed
    46. Goldspink PH, Montgomery DE, Walker LA, Urboniene D, McKinney RD, Geenen DL, Solaro RJ, Buttrick PM. Protein kinase Cepsilon overexpression alters myofilament properties and composition during the progression of heart failure. Circ Res. 2004 Aug 20; 95(4):424-32. PMID: 15242976.
      View in: PubMed
    Lori's Networks
    Concepts
    Derived automatically from this person's publications.
    _
    Co-Authors
    People in Profiles who have published with this person.
    _
    Similar People
    People who share similar concepts with this person.
    _
    Same Department