Lee Ann Baxter-Lowe, PhD

Title(s)Professor Of Clinical Pathology
SchoolKeck School of Medicine of Usc
Address4640 West Sunset Blvd
Off Campus
Los Angeles CA 90027
Phone+1 323 361 5279
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    Dr Baxter-Lowe's research involves characterizing HLA polymorphism and determining its relevance in transplantation and human disease. In recent years she has been investigating the role of HLA antibodies in transplantation of solid organs and hematopoietic stem cells. Her laboratory has supported numerous single and multicenter clinical trials in transplantation and has been a core laboratory for the NIH Immune Tolerance Network. Her research has been reported in more than 125 scientific publications.

    Dr. Baxter-Lowe has also served as a clinical histocompatibility laboratory director and in this capacity has been involved in advancing histocompatibility testing and its clinical application. She has had a long-standing commitment to policy development and is currently serving as Chair of the Histocompatibility Committee of the United Network for Organ Sharing (UNOS) and is the facilitator for the Histocompatibility Workgroup for the 2012 National Consensus Conference on Kidney Paired Donation (KPD). She has served as a member or chair of numerous national and international committees in this field.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. HLA diversity in ethnic populations can affect detection of donor-specific antibodies by single antigen beads. Front Immunol. 2023; 14:1287028. Quon JC, Kaneta K, Fotiadis N, Menteer J, Lestz RM, Weisert M, Baxter-Lowe LA. PMID: 38077376; PMCID: PMC10701672.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Next generation multiplexing for digital PCR using a novel melt-based hairpin probe design. Front Genet. 2023; 14:1272964. Edwards RL, Takach JE, McAndrew MJ, Menteer J, Lestz RM, Whitman D, Baxter-Lowe LA. PMID: 38028620; PMCID: PMC10667681.
      View in: PubMed   Mentions: 1  
    3. Donor chimerism and immune reconstitution following haploidentical transplantation in sickle cell disease. Front Immunol. 2022; 13:1055497. Chu Y, Talano JA, Baxter-Lowe LA, Verbsky JW, Morris E, Mahanti H, Ayello J, Keever-Taylor C, Johnson B, Weinberg RS, Shi Q, Moore TB, Fabricatore S, Grossman B, van de Ven C, Shenoy S, Cairo MS. PMID: 36569951; PMCID: PMC9780682.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    4. Cell-free DNA as a solid-organ transplant biomarker: technologies and approaches. Biomark Med. 2022 04; 16(5):401-415. Edwards RL, Menteer J, Lestz RM, Baxter-Lowe LA. PMID: 35195028.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    5. Defining and characterizing HLA diversity. Hum Immunol. 2021 07; 82(7):455-456. Baxter-Lowe LA. PMID: 34059370.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. The changing landscape of HLA typing: Understanding how and when HLA typing data can be used with confidence from bench to bedside. Hum Immunol. 2021 Jul; 82(7):466-477. Baxter-Lowe LA. PMID: 34030895.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    7. The discovery of the HLA-B*56:75 allele shows that HLA sequencing is important in all transplant settings. HLA. 2021 05; 97(5):463-464. Quon JC, Lyle WD, Baxter-Lowe LA. PMID: 33369190.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Growing evidence that 2-field high-resolution HLA typing is important for kidney transplantation. Am J Transplant. 2020 12; 20(12):3277-3278. Baxter-Lowe LA. PMID: 32484291.
      View in: PubMed   Mentions: 1     Fields:    
    9. The clinical impact of donor-specific antibodies on antibody-mediated rejection and long-term prognosis after heart transplantation. Curr Opin Organ Transplant. 2019 06; 24(3):245-251. Su JA, Baxter-Lowe LA, Kantor PF, Szmuszkovicz JR, Menteer J. PMID: 31090631.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    10. Human leukocyte antigens antibodies after lung transplantation: Primary results of the HALT study. Am J Transplant. 2018 09; 18(9):2285-2294. Hachem RR, Kamoun M, Budev MM, Askar M, Ahya VN, Lee JC, Levine DJ, Pollack MS, Dhillon GS, Weill D, Schechtman KB, Leard LE, Golden JA, Baxter-Lowe L, Mohanakumar T, Tyan DB, Yusen RD. PMID: 29687961; PMCID: PMC6117197.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    11. CPRA for allocation of kidneys in the US: More candidates ≥98% CPRA, lower positive crossmatch rates and improved transplant rates for sensitized patients. Hum Immunol. 2016 May; 77(5):395-402. Baxter-Lowe LA, Kucheryavaya A, Tyan D, Reinsmoen N. PMID: 27012168.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansPHPublic Health
    12. Impact of allele-level HLA matching on outcomes after myeloablative single unit umbilical cord blood transplantation for hematologic malignancy. Blood. 2014 Jan 02; 123(1):133-40. Eapen M, Klein JP, Ruggeri A, Spellman S, Lee SJ, Anasetti C, Arcese W, Barker JN, Baxter-Lowe LA, Brown M, Fernandez-Vina MA, Freeman J, He W, Iori AP, Horowitz MM, Locatelli F, Marino S, Maiers M, Michel G, Sanz GF, Gluckman E, Rocha V, Center for International Blood and Marrow Transplant Research, Netcord, Eurocord, and the European G. PMID: 24141369; PMCID: PMC3879902.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansCells
    13. Amino acid substitution at peptide-binding pockets of HLA class I molecules increases risk of severe acute GVHD and mortality. Blood. 2013 Nov 21; 122(22):3651-8. Pidala J, Wang T, Haagenson M, Spellman SR, Askar M, Battiwalla M, Baxter-Lowe LA, Bitan M, Fernandez-Viña M, Gandhi M, Jakubowski AA, Maiers M, Marino SR, Marsh SG, Oudshoorn M, Palmer J, Prasad VK, Reddy V, Ringden O, Saber W, Santarone S, Schultz KR, Setterholm M, Trachtenberg E, Turner EV, Woolfrey AE, Lee SJ, Anasetti C. PMID: 23982174; PMCID: PMC3837514.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    14. Effect of HLA-matching recipients to donor noninherited maternal antigens on outcomes after mismatched umbilical cord blood transplantation for hematologic malignancy. Biol Blood Marrow Transplant. 2012 Dec; 18(12):1890-6. Rocha V, Spellman S, Zhang MJ, Ruggeri A, Purtill D, Brady C, Baxter-Lowe LA, Baudoux E, Bergamaschi P, Chow R, Freed B, Koegler G, Kurtzberg J, Larghero J, Lecchi L, Nagler A, Navarrette C, Prasad V, Pouthier F, Price T, Ratanatharathorn V, van Rood JJ, Horowitz MM, Gluckman E, Eapen M, Eurocord-European Blood and Marrow Transplant Group and the Center for International Blood and Marro. PMID: 22814031; PMCID: PMC3826155.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    15. Scoring HLA class I mismatches by HistoCheck does not predict clinical outcome in unrelated hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2012 May; 18(5):739-46. Spellman S, Klein J, Haagenson M, Askar M, Baxter-Lowe LA, He J, Hsu S, Blasczyk R, Hurley C. PMID: 21963622; PMCID: PMC3270214.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    16. Kidney transplantation at UCSF: 8,300 transplants and onward. Clin Transpl. 2010; 161-7. Wojciechowski D, Hirose R, Stock P, Vincenti F, Baxter-Lowe LA, Salvatierra O. PMID: 21696039.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. Advancement and clinical implications of HLA typing in allogeneic hematopoietic stem cell transplantation. Cancer Treat Res. 2009; 144:71-94. Baxter-Lowe LA, Hurley CK. PMID: 19779873.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    18. Results of the Cord Blood Transplantation Study (COBLT): clinical outcomes of unrelated donor umbilical cord blood transplantation in pediatric patients with hematologic malignancies. Blood. 2008 Nov 15; 112(10):4318-27. Kurtzberg J, Prasad VK, Carter SL, Wagner JE, Baxter-Lowe LA, Wall D, Kapoor N, Guinan EC, Feig SA, Wagner EL, Kernan NA, COBLT Steering Committee. PMID: 18723429; PMCID: PMC2581998.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansCTClinical Trials
    19. High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation. Blood. 2007 Dec 15; 110(13):4576-83. Lee SJ, Klein J, Haagenson M, Baxter-Lowe LA, Confer DL, Eapen M, Fernandez-Vina M, Flomenberg N, Horowitz M, Hurley CK, Noreen H, Oudshoorn M, Petersdorf E, Setterholm M, Spellman S, Weisdorf D, Williams TM, Anasetti C. PMID: 17785583.
      View in: PubMed   Mentions: 463     Fields:    Translation:Humans
    20. A high degree of HLA disparity arises from limited allelic diversity: analysis of 1775 unrelated bone marrow transplant donor-recipient pairs. Hum Immunol. 2007 Jan; 68(1):30-40. Hurley CK, Fernandez-Vina M, Hildebrand WH, Noreen HJ, Trachtenberg E, Williams TM, Baxter-Lowe LA, Begovich AB, Petersdorf E, Selvakumar A, Stastny P, Hegland J, Hartzman RJ, Carston M, Gandham S, Kollman C, Nelson G, Spellman S, Setterholm M. PMID: 17207710.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    21. Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome. Blood. 2004 Oct 01; 104(7):1923-30. Flomenberg N, Baxter-Lowe LA, Confer D, Fernandez-Vina M, Filipovich A, Horowitz M, Hurley C, Kollman C, Anasetti C, Noreen H, Begovich A, Hildebrand W, Petersdorf E, Schmeckpeper B, Setterholm M, Trachtenberg E, Williams T, Yunis E, Weisdorf D. PMID: 15191952.
      View in: PubMed   Mentions: 195     Fields:    Translation:HumansCells
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