Jason T Shafrin

Title(s)Adjunct Assistant Professor of Pharmaceutical and Health Economics
SchoolUSC School of Pharmacy
Address635 Downey Way
University Park Campus
Los Angeles CA 90089
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    1. Will the Institute for Clinical and Economic Review's Shared Savings Approach Decrease Value-Based Prices Most for the Most Severe Diseases? Value Health. 2024 Sep 30. Shafrin J, Wang S, Sharma K, Spurrier K, Nordyke RJ. PMID: 39357669.
      View in: PubMed   Mentions:    Fields:    
    2. Healthcare Stakeholder Perspectives on a Value Assessment Approach for Duchenne Muscular Dystrophy Therapies. J Multidiscip Healthc. 2024; 17:4199-4212. Fischer R, Furlong P, Kennedy A, Maynard K, Penrod M, Miller D, Laverty CG, Lowes LP, Kuntz NL, Shieh PB, Kondejewski J, Neumann PJ, Shafrin J, Willke RJ. PMID: 39224484; PMCID: PMC11368110.
      View in: PubMed   Mentions:
    3. Economic Value of Bronchoscopy Technologies that Improves Sensitivity for Malignancy for Peripheral Pulmonary Lesions. Ann Am Thorac Soc. 2024 Aug 23. Ost DE, Maldonado F, Shafrin J, Kim J, Marin MA, Amos TB, Hertz DS, Kalsekar I, Vachani A. PMID: 39178335.
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    4. How adoption of new pharmaceuticals can impact US health system reimbursement under alternative payment models: An economic model measuring the impact of sotagliflozin among patients with heart failure and diabetes. J Manag Care Spec Pharm. 2024 Aug; 30(8):843-853. Shafrin J, Wang S, Kim J, Sikirica S, Sandhu AT. PMID: 38989709; PMCID: PMC11293769.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Quantifying the insurance value for rare diseases: Duchenne muscular dystrophy. Am J Manag Care. 2024 07 01; 30(7):e217-e222. Shafrin J, Thahir S, Klimchak AC, Audhya I, Sedita LE, Romley JA. PMID: 38995826.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Cost-effectiveness of sotagliflozin for the treatment of patients with diabetes and recent worsening heart failure. J Comp Eff Res. 2024 Jun; 13(6):e230190. Kim J, Wang S, Sikirica S, Shafrin J. PMID: 38771012; PMCID: PMC11145521.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Quantifying the Value of Reduced Health Disparities: Low-Dose Computed Tomography Lung Cancer Screening of High-Risk Individuals Within the United States. Value Health. 2024 03; 27(3):313-321. Shafrin J, Kim J, Marin M, Ramsagar S, Davies ML, Stewart K, Kalsekar I, Vachani A. PMID: 38191024.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    8. Treatment Patterns and Healthcare Resource Utilization of Patients With Paroxysmal Nocturnal Hemoglobinuria: A Retrospective Claims Data Analysis. Clin Appl Thromb Hemost. 2024 Jan-Dec; 30:10760296231213073. Clayton D, Shafrin J, Yen G, Lee S, Geevarghese L, Shi Y, He L, Shen Y, Waheed A. PMID: 38173351; PMCID: PMC10768575.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Use of Conditionally Essential Amino Acids and the Economic Burden of Postoperative Complications After Fracture Fixation: Results from a Cost Utility Analysis. Clinicoecon Outcomes Res. 2023; 15:753-764. Shafrin J, Than KS, Kanotra A, Kerr KW, Robinson KN, Willey MC. PMID: 37904809; PMCID: PMC10613425.
      View in: PubMed   Mentions: 1  
    10. A Decade of Health Innovation: The Impact of New Medicines on Patient Health and the Implications for NICE's Size of Benefit Multiplier. Value Health. 2023 10; 26(10):1435-1439. Shafrin J, Quddus S, Marin M, Scanlon D. PMID: 37391164.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. Impact of suboptimal or inappropriate treatment on healthcare resource use and cost among patients with uncomplicated urinary tract infection: an analysis of integrated delivery network electronic health records. Antimicrob Resist Infect Control. 2022 11 04; 11(1):133. Shafrin J, Marijam A, Joshi AV, Mitrani-Gold FS, Everson K, Tuly R, Rosenquist P, Gillam M, Ruiz ME. PMID: 36333740; PMCID: PMC9636777.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    12. Health care utilization and costs associated with functional status in patients with psoriatic arthritis. J Manag Care Spec Pharm. 2022 Sep; 28(9):997-1007. Ogdie A, Hwang M, Veeranki P, Portelli A, Sison S, Shafrin J, Pedro S, Hass S, Hur P, Kim N, Yi E, Michaud K. PMID: 36001101; PMCID: PMC10372953.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    13. Association of health care utilization and costs with patient-reported outcomes in patients with ankylosing spondylitis. J Manag Care Spec Pharm. 2022 Sep; 28(9):1008-1020. Ogdie A, Hwang M, Veeranki P, Portelli A, Sison S, Shafrin J, Pedro S, Kim N, Yi E, Michaud K. PMID: 36001102; PMCID: PMC10373008.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    14. Economic burden of antibiotic-not-susceptible isolates in uncomplicated urinary tract infection: Analysis of a US integrated delivery network database. Antimicrob Resist Infect Control. 2022 06 14; 11(1):84. Shafrin J, Marijam A, Joshi AV, Mitrani-Gold FS, Everson K, Tuly R, Rosenquist P, Gillam M, Ruiz ME. PMID: 35701853; PMCID: PMC9195273.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    15. Are caregivers ready for digital? Caregiver preferences for health technology tools to monitor medication adherence among patients with serious mental illness. Digit Health. 2022 Jan-Dec; 8:20552076221084472. Forma F, Chiu K, Shafrin J, Boskovic DH, Veeranki SP. PMID: 35295765; PMCID: PMC8918958.
      View in: PubMed   Mentions: 6  
    16. White Paper on the Value of Time Savings for Patients and Healthcare Providers of Breast Cancer Therapy: The Fixed-Dose Combination of Pertuzumab and Trastuzumab for Subcutaneous Injection as an Example. Adv Ther. 2022 02; 39(2):833-844. Jackisch C, Manevy F, Frank S, Roberts N, Shafrin J. PMID: 34988876; PMCID: PMC8730478.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. Estimating the impact of biosimilar entry on prices and expenditures in rheumatoid arthritis: a case study of targeted immune modulators. J Med Econ. 2022 Jan-Dec; 25(1):1118-1126. Maksabedian Hernandez EJ, Graf M, Portelli A, Shafrin J. PMID: 35965481.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    18. When Should You Trust Your Doctor? Establishing a Theoretical Model to Evaluate the Value of Second Opinion Visits. Mayo Clin Proc Innov Qual Outcomes. 2021 Apr; 5(2):502-510. Halasy M, Shafrin J. PMID: 33997646; PMCID: PMC8105538.
      View in: PubMed   Mentions: 1  
    19. Measuring the Value Healthy Individuals Place on Generous Insurance Coverage of Severe Diseases: A Stated Preference Survey of Adults Diagnosed With and Without Lung Cancer. Value Health. 2021 06; 24(6):855-861. Shafrin J, May SG, Zhao LM, Bognar K, Yuan Y, Penrod JR, Romley JA. PMID: 34119084.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    20. For which diseases do broader value elements matter most? An evaluation across 20 ICER evidence reports. J Manag Care Spec Pharm. 2021 May; 27(5):650-659. Shafrin J, Dennen S, Pednekar P, Birch K, Bhor M, Kanter J, Neumann P. PMID: 33779245; PMCID: PMC10394200.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    21. The impact of vaso-occlusive crises and disease severity on quality of life and productivity among patients with sickle cell disease in the US. Curr Med Res Opin. 2021 05; 37(5):761-768. Shafrin J, Thom HHZ, Keeney E, Gaunt DM, Zhao LM, Bhor M, Rizio AA, Bronté-Hall L, Shah N. PMID: 33686891.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    22. Adoption of Digital Health Technologies in the Practice of Behavioral Health: Qualitative Case Study of Glucose Monitoring Technology. J Med Internet Res. 2021 02 03; 23(2):e18119. May SG, Huber C, Roach M, Shafrin J, Aubry W, Lakdawalla D, Kane JM, Forma F. PMID: 33533725; PMCID: PMC7889421.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    23. Quantifying spillover benefits in value assessment: a case study of increased graft survival on the US kidney transplant waitlist. J Med Econ. 2021 Jan-Dec; 24(1):918-928. Dennen S, Díaz Espinosa O, Birch K, Cai J, Sung JC, Machado PGP, Shafrin J. PMID: 34275421.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    24. Changes in mortality associated with cancer drug approvals in the United States from 2000 to 2016. J Med Econ. 2020 Dec; 23(12):1558-1569. MacEwan JP, Dennen S, Kee R, Ali F, Shafrin J, Batt K. PMID: 33161782.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    25. Alternative payment models and innovation: a case study of US health system adoption of a sacubitril/valsartan to treat acute decompensated heart failure. J Med Econ. 2020 Dec; 23(12):1450-1460. Shafrin J, Aliyev ER, Brauer M, Park S, Shen X. PMID: 32945737.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    26. Crizanlizumab and comparators for adults with sickle cell disease: a systematic review and network meta-analysis. BMJ Open. 2020 09 17; 10(9):e034147. Thom H, Jansen J, Shafrin J, Zhao L, Joseph G, Cheng HY, Gupta S, Shah N. PMID: 32948541; PMCID: PMC7500297.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    27. Modeling the impact of patient treatment preference on health outcomes in relapsing-remitting multiple sclerosis. J Med Econ. 2020 May; 23(5):474-483. van Eijndhoven E, Brauer M, Kee R, MacEwan J, Mucha L, Wong SL, Durand A, Shafrin J. PMID: 31903813.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    28. A Flexible Open-Source Decision Model for Value Assessment of Biologic Treatment for Rheumatoid Arthritis. Pharmacoeconomics. 2019 06; 37(6):829-843. Incerti D, Curtis JR, Shafrin J, Lakdawalla DN, Jansen JP. PMID: 30737711.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    29. Using Information on Patient Adherence to Antipsychotic Medication to Understand Their Adherence to Other Medications. P T. 2019 Jun; 44(6):350-357. Shafrin J, Silverstein AR, MacEwan JP, Lakdawalla DN, Hatch A, Forma FM. PMID: 31160870; PMCID: PMC6534179.
      View in: PubMed   Mentions: 2  
    30. The economic burden of switching targeted disease-modifying anti-rheumatic drugs among rheumatoid arthritis patients. J Med Econ. 2019 Apr; 22(4):350-358. Shahabi A, Shafrin J, Zhao L, Green S, Curtice T, Marshall A, Paul D. PMID: 30653389.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    31. Does knowledge of patient non-compliance change prescribing behavior in the real world? A claims-based analysis of patients with serious mental illness. Clinicoecon Outcomes Res. 2018; 10:573-585. Shafrin J, Bognar K, Everson K, Brauer M, Lakdawalla DN, Forma FM. PMID: 30323635; PMCID: PMC6173173.
      View in: PubMed   Mentions: 5  
    32. The potential value of rapid, cloud-enabled onsite testing for the diagnosis of rheumatoid arthritis in the United States. J Med Econ. 2018 Nov; 21(11):1057-1066. Bognar K, Shafrin J, Brauer M, Zhao L, Hockett R, O'Neil M, Jena A. PMID: 30019600.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    33. Medication Adherence Patterns Among Patients with Multiple Serious Mental and Physical Illnesses. Adv Ther. 2018 May; 35(5):671-685. MacEwan JP, Silverstein AR, Shafrin J, Lakdawalla DN, Hatch A, Forma FM. PMID: 29725982; PMCID: PMC5960492.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    34. An exploratory case study of the impact of expanding cost-effectiveness analysis for second-line nivolumab for patients with squamous non-small cell lung cancer in Canada: Does it make a difference? Health Policy. 2018 06; 122(6):607-613. Shafrin J, Skornicki M, Brauer M, Villeneuve J, Lees M, Hertel N, Penrod JR, Jansen J. PMID: 29731176.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    35. Estimated prevalence of undiagnosed atrial fibrillation in the United States. PLoS One. 2018; 13(4):e0195088. Turakhia MP, Shafrin J, Bognar K, Trocio J, Abdulsattar Y, Wiederkehr D, Goldman DP. PMID: 29649277; PMCID: PMC5896911.
      View in: PubMed   Mentions: 68     Fields:    Translation:Humans
    36. Long-Term Health and Economic Value of Improved Mobility among Older Adults in the United States. Value Health. 2018 07; 21(7):792-798. Kabiri M, Brauer M, Shafrin J, Sullivan J, Gill TM, Goldman DP. PMID: 30005751; PMCID: PMC6078098.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    37. The effect of medication nonadherence on progression-free survival among patients with renal cell carcinoma. Cancer Manag Res. 2017; 9:731-739. Shafrin J, Sullivan J, Chou JW, Neely MN, Doan JF, Maclean JR. PMID: 29238223; PMCID: PMC5713701.
      View in: PubMed   Mentions: 7  
    38. The association between observed mobility and quality of life in the near elderly. PLoS One. 2017; 12(8):e0182920. Shafrin J, Sullivan J, Goldman DP, Gill TM. PMID: 28827806; PMCID: PMC5572211.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    39. The Economic Burden of ACPA-Positive Status Among Patients with Rheumatoid Arthritis. J Manag Care Spec Pharm. 2018 Jan; 24(1):4-11. Shafrin J, Tebeka MG, Price K, Patel C, Michaud K. PMID: 29290168; PMCID: PMC10398189.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    40. Access to credible information on schizophrenia patients' medication adherence by prescribers can change their treatment strategies: evidence from an online survey of providers. Patient Prefer Adherence. 2017; 11:1071-1081. Shafrin J, May SG, Shrestha A, Ruetsch C, Gerlanc N, Forma F, Hatch A, Lakdawalla DN, Lindenmayer JP. PMID: 28721020; PMCID: PMC5499864.
      View in: PubMed   Mentions: 8  
    41. Value-Based Payments and Incentives to Improve Care: A Case Study of Patients with Type 2 Diabetes in Medicare Advantage. Value Health. 2017 09; 20(8):1216-1220. Sussell J, Bognar K, Schwartz TT, Shafrin J, Sheehan JJ, Aubry W, Scanlon D. PMID: 28964455.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    42. Value Tools in Managed Care Decision Making: Current Hurdles and Future Opportunities. J Manag Care Spec Pharm. 2017 Jun; 23(6-a Suppl):S21-S27. Schafer J, Galante D, Shafrin J. PMID: 28535106; PMCID: PMC10408398.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    43. Predicting Real-World Effectiveness of Cancer Therapies Using Overall Survival and Progression-Free Survival from Clinical Trials: Empirical Evidence for the ASCO Value Framework. Value Health. 2017 Jul - Aug; 20(7):866-875. Lakdawalla DN, Shafrin J, Hou N, Peneva D, Vine S, Park J, Zhang J, Brookmeyer R, Figlin RA. PMID: 28712615.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    44. The cost of adherence mismeasurement in serious mental illness: a claims-based analysis. Am J Manag Care. 2017 May 01; 23(5):e156-e163. Shafrin J, Forma F, Scherer E, Hatch A, Vytlacil E, Lakdawalla D. PMID: 28810130.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    45. Patient Versus Physician Valuation of Durable Survival Gains: Implications for Value Framework Assessments. Value Health. 2017 02; 20(2):217-223. Shafrin J, Schwartz TT, Okoro T, Romley JA. PMID: 28237198.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    46. Geographic Variation in Diagnostic Ability and Quality of Care Metrics: A Case Study of Ankylosing Spondylitis and Low Back Pain. Inquiry. 2017 01 01; 54:46958017707873. Shafrin J, Griffith J, Shim JJ, Huber C, Ganguli A, Aubry W. PMID: 28548005; PMCID: PMC5798677.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    47. Geographic Variation in the Quality and Cost of Care for Patients with Rheumatoid Arthritis. J Manag Care Spec Pharm. 2016 Dec; 22(12):1472-1481. Shafrin J, Ganguli A, Gonzalez YS, Shim JJ, Seabury SA. PMID: 27882832; PMCID: PMC10398269.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    48. Estimating the Value of New Technologies That Provide More Accurate Drug Adherence Information to Providers for Their Patients with Schizophrenia. J Manag Care Spec Pharm. 2016 Nov; 22(11):1285-1291. Shafrin J, Schwartz TT, Lakdawalla DN, Forma FM. PMID: 27783545; PMCID: PMC10397938.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    49. Patterns of Adherence to Oral Atypical Antipsychotics Among Patients Diagnosed with Schizophrenia. J Manag Care Spec Pharm. 2016 Nov; 22(11):1349-1361. MacEwan JP, Forma FM, Shafrin J, Hatch A, Lakdawalla DN, Lindenmayer JP. PMID: 27783548; PMCID: PMC10397601.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    50. Evaluating Matching-Adjusted Indirect Comparisons in Practice: A Case Study of Patients with Attention-Deficit/Hyperactivity Disorder. Health Econ. 2017 11; 26(11):1459-1466. Shafrin J, Shrestha A, Chandra A, Erder MH, Sikirica V. PMID: 27620206.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    51. Utility of Cancer Value Frameworks for Patients, Payers, and Physicians. JAMA. 2016 May 17; 315(19):2069-70. Chandra A, Shafrin J, Dhawan R. PMID: 27187295.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    52. Physician and Patient Preferences for Nonvalvular Atrial Fibrillation Therapies. Value Health. 2016 06; 19(4):451-9. Shafrin J, Bruno A, MacEwan JP, Campinha-Bacote A, Trocio J, Shah M, Tan W, Romley JA. PMID: 27325337.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    53. The value of surrogate endpoints for predicting real-world survival across five cancer types. Curr Med Res Opin. 2016; 32(4):731-9. Shafrin J, Brookmeyer R, Peneva D, Park J, Zhang J, Figlin RA, Lakdawalla DN. PMID: 26743800.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    54. Economic Burden of Undiagnosed Nonvalvular Atrial Fibrillation in the United States. Am J Cardiol. 2015 Sep 01; 116(5):733-9. Turakhia MP, Shafrin J, Bognar K, Goldman DP, Mendys PM, Abdulsattar Y, Wiederkehr D, Trocio J. PMID: 26138378.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    55. Quality-adjusted cost of care: a meaningful way to measure growth in innovation cost versus the value of health gains. Health Aff (Millwood). 2015 Apr; 34(4):555-61. Lakdawalla D, Shafrin J, Lucarelli C, Nicholson S, Khan ZM, Philipson TJ. PMID: 25847636; PMCID: PMC4406284.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    56. Regional Growth in Medicare Spending, 1992-2010. Health Serv Res. 2015 Oct; 50(5):1574-88. Chicklis C, MaCurdy T, Bhattacharya J, Shafrin J, Zaidi S, Rogers D. PMID: 25676603; PMCID: PMC4600362.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    57. Methodological Assessment of Matching-Adjusted Indirect Comparisons: Case Study Application To Attention Deficit/Hyperactivity Disorder (Adhd). Value Health. 2014 Nov; 17(7):A579. Shafrin J, Sikirica V, Shrestha A, Henkhaus LE, Erder MH, Chandra A. PMID: 27201950.
      View in: PubMed   Mentions:    Fields:    
    58. Operating on commission: analyzing how physician financial incentives affect surgery rates. Health Econ. 2010 May; 19(5):562-80. Shafrin J. PMID: 19399752.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    59. Delivering vaccines: a case study of the distribution system of Vaccines for Children. Am J Manag Care. 2009 Oct; 15(10):751-4. Shafrin JT, Fontanesi JM. PMID: 19845427.
      View in: PubMed   Mentions:    Fields:    
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