Jason T Shafrin

Title(s)Adjunct Assistant Professor of Pharmaceutical and Health Economics
SchoolUSC School of Pharmacy
Address635 Downey Way
University Park Campus
Los Angeles CA 90089
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    1. Economic Value of Bronchoscopy Technologies that Improves Sensitivity for Malignancy for Peripheral Pulmonary Lesions. Ann Am Thorac Soc. 2024 Dec; 21(12):1759-1769. Ost DE, Maldonado F, Shafrin J, Kim J, Marin MA, Amos TB, Hertz DS, Kalsekar I, Vachani A. PMID: 39178335; PMCID: PMC11622820.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    2. Impact of delayed adoption of novel atrial fibrillation treatments. Am J Manag Care. 2024 Dec; 30(12):674-680. Kim J, Nighohossian J, Daifotis AG, He J, Shafrin J. PMID: 39745511.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Health economic value of postacute oral nutritional supplementation in older adult medical patients at risk for malnutrition: a US-based modelling approach. BMJ Open. 2024 Nov 17; 14(11):e086787. Wang S, Shafrin J, Kerr KW, Schuetz P. PMID: 39551592; PMCID: PMC11574475.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. A Retrospective Claims Analysis of the Rate of Complications in Patients Undergoing Treatment for Paroxysmal Nocturnal Hemoglobinuria. Adv Ther. 2025 Jan; 42(1):500-509. Clayton D, Shafrin J, Yen GP, Geevarghese L, Shi Y, Waheed A. PMID: 39499488; PMCID: PMC11782294.
      View in: PubMed   Mentions:    Fields:    
    5. Will the Institute for Clinical and Economic Review's Shared Savings Approach Decrease Value-Based Prices Most for the Most Severe Diseases? Value Health. 2025 Jan; 28(1):25-30. Shafrin J, Wang S, Sharma K, Spurrier K, Nordyke RJ. PMID: 39357669.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Healthcare Stakeholder Perspectives on a Value Assessment Approach for Duchenne Muscular Dystrophy Therapies. J Multidiscip Healthc. 2024; 17:4199-4212. Fischer R, Furlong P, Kennedy A, Maynard K, Penrod M, Miller D, Laverty CG, Lowes LP, Kuntz NL, Shieh PB, Kondejewski J, Neumann PJ, Shafrin J, Willke RJ. PMID: 39224484; PMCID: PMC11368110.
      View in: PubMed   Mentions:
    7. How adoption of new pharmaceuticals can impact US health system reimbursement under alternative payment models: An economic model measuring the impact of sotagliflozin among patients with heart failure and diabetes. J Manag Care Spec Pharm. 2024 Aug; 30(8):843-853. Shafrin J, Wang S, Kim J, Sikirica S, Sandhu AT. PMID: 38989709; PMCID: PMC11293769.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Quantifying the insurance value for rare diseases: Duchenne muscular dystrophy. Am J Manag Care. 2024 07 01; 30(7):e217-e222. Shafrin J, Thahir S, Klimchak AC, Audhya I, Sedita LE, Romley JA. PMID: 38995826.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    9. Valuing the Societal Impact of Medicines and Other Health Technologies: A User Guide to Current Best Practices. Forum Health Econ Policy. 2024 Jun 01; 27(1):29-116. Shafrin J, Kim J, Cohen JT, Garrison LP, Goldman DA, Doshi JA, Krieger J, Lakdawalla DN, Neumann PJ, Phelps CE, Whittington MD, Willke R. PMID: 39512185; PMCID: PMC11567015.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. Cost-effectiveness of sotagliflozin for the treatment of patients with diabetes and recent worsening heart failure. J Comp Eff Res. 2024 06; 13(6):e230190. Kim J, Wang S, Sikirica S, Shafrin J. PMID: 38771012; PMCID: PMC11145521.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. Quantifying the Value of Reduced Health Disparities: Low-Dose Computed Tomography Lung Cancer Screening of High-Risk Individuals Within the United States. Value Health. 2024 03; 27(3):313-321. Shafrin J, Kim J, Marin M, Ramsagar S, Davies ML, Stewart K, Kalsekar I, Vachani A. PMID: 38191024.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    12. Treatment Patterns and Healthcare Resource Utilization of Patients With Paroxysmal Nocturnal Hemoglobinuria: A Retrospective Claims Data Analysis. Clin Appl Thromb Hemost. 2024 Jan-Dec; 30:10760296231213073. Clayton D, Shafrin J, Yen G, Lee S, Geevarghese L, Shi Y, He L, Shen Y, Waheed A. PMID: 38173351; PMCID: PMC10768575.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. Use of Conditionally Essential Amino Acids and the Economic Burden of Postoperative Complications After Fracture Fixation: Results from a Cost Utility Analysis. Clinicoecon Outcomes Res. 2023; 15:753-764. Shafrin J, Than KS, Kanotra A, Kerr KW, Robinson KN, Willey MC. PMID: 37904809; PMCID: PMC10613425.
      View in: PubMed   Mentions: 1  
    14. A Decade of Health Innovation: The Impact of New Medicines on Patient Health and the Implications for NICE's Size of Benefit Multiplier. Value Health. 2023 10; 26(10):1435-1439. Shafrin J, Quddus S, Marin M, Scanlon D. PMID: 37391164.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    15. Impact of suboptimal or inappropriate treatment on healthcare resource use and cost among patients with uncomplicated urinary tract infection: an analysis of integrated delivery network electronic health records. Antimicrob Resist Infect Control. 2022 11 04; 11(1):133. Shafrin J, Marijam A, Joshi AV, Mitrani-Gold FS, Everson K, Tuly R, Rosenquist P, Gillam M, Ruiz ME. PMID: 36333740; PMCID: PMC9636777.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    16. Health care utilization and costs associated with functional status in patients with psoriatic arthritis. J Manag Care Spec Pharm. 2022 Sep; 28(9):997-1007. Ogdie A, Hwang M, Veeranki P, Portelli A, Sison S, Shafrin J, Pedro S, Hass S, Hur P, Kim N, Yi E, Michaud K. PMID: 36001101; PMCID: PMC10372953.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    17. Association of health care utilization and costs with patient-reported outcomes in patients with ankylosing spondylitis. J Manag Care Spec Pharm. 2022 Sep; 28(9):1008-1020. Ogdie A, Hwang M, Veeranki P, Portelli A, Sison S, Shafrin J, Pedro S, Kim N, Yi E, Michaud K. PMID: 36001102; PMCID: PMC10373008.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    18. Economic burden of antibiotic-not-susceptible isolates in uncomplicated urinary tract infection: Analysis of a US integrated delivery network database. Antimicrob Resist Infect Control. 2022 06 14; 11(1):84. Shafrin J, Marijam A, Joshi AV, Mitrani-Gold FS, Everson K, Tuly R, Rosenquist P, Gillam M, Ruiz ME. PMID: 35701853; PMCID: PMC9195273.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    19. Are caregivers ready for digital? Caregiver preferences for health technology tools to monitor medication adherence among patients with serious mental illness. Digit Health. 2022 Jan-Dec; 8:20552076221084472. Forma F, Chiu K, Shafrin J, Boskovic DH, Veeranki SP. PMID: 35295765; PMCID: PMC8918958.
      View in: PubMed   Mentions: 5  
    20. White Paper on the Value of Time Savings for Patients and Healthcare Providers of Breast Cancer Therapy: The Fixed-Dose Combination of Pertuzumab and Trastuzumab for Subcutaneous Injection as an Example. Adv Ther. 2022 02; 39(2):833-844. Jackisch C, Manevy F, Frank S, Roberts N, Shafrin J. PMID: 34988876; PMCID: PMC8730478.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    21. Estimating the impact of biosimilar entry on prices and expenditures in rheumatoid arthritis: a case study of targeted immune modulators. J Med Econ. 2022 Jan-Dec; 25(1):1118-1126. Maksabedian Hernandez EJ, Graf M, Portelli A, Shafrin J. PMID: 35965481.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    22. When Should You Trust Your Doctor? Establishing a Theoretical Model to Evaluate the Value of Second Opinion Visits. Mayo Clin Proc Innov Qual Outcomes. 2021 Apr; 5(2):502-510. Halasy M, Shafrin J. PMID: 33997646; PMCID: PMC8105538.
      View in: PubMed   Mentions: 1  
    23. Measuring the Value Healthy Individuals Place on Generous Insurance Coverage of Severe Diseases: A Stated Preference Survey of Adults Diagnosed With and Without Lung Cancer. Value Health. 2021 06; 24(6):855-861. Shafrin J, May SG, Zhao LM, Bognar K, Yuan Y, Penrod JR, Romley JA. PMID: 34119084.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    24. For which diseases do broader value elements matter most? An evaluation across 20 ICER evidence reports. J Manag Care Spec Pharm. 2021 May; 27(5):650-659. Shafrin J, Dennen S, Pednekar P, Birch K, Bhor M, Kanter J, Neumann P. PMID: 33779245; PMCID: PMC10394200.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    25. The impact of vaso-occlusive crises and disease severity on quality of life and productivity among patients with sickle cell disease in the US. Curr Med Res Opin. 2021 05; 37(5):761-768. Shafrin J, Thom HHZ, Keeney E, Gaunt DM, Zhao LM, Bhor M, Rizio AA, Bronté-Hall L, Shah N. PMID: 33686891.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    26. Adoption of Digital Health Technologies in the Practice of Behavioral Health: Qualitative Case Study of Glucose Monitoring Technology. J Med Internet Res. 2021 02 03; 23(2):e18119. May SG, Huber C, Roach M, Shafrin J, Aubry W, Lakdawalla D, Kane JM, Forma F. PMID: 33533725; PMCID: PMC7889421.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    27. Quantifying spillover benefits in value assessment: a case study of increased graft survival on the US kidney transplant waitlist. J Med Econ. 2021 Jan-Dec; 24(1):918-928. Dennen S, Díaz Espinosa O, Birch K, Cai J, Sung JC, Machado PGP, Shafrin J. PMID: 34275421.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    28. Changes in mortality associated with cancer drug approvals in the United States from 2000 to 2016. J Med Econ. 2020 Dec; 23(12):1558-1569. MacEwan JP, Dennen S, Kee R, Ali F, Shafrin J, Batt K. PMID: 33161782.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    29. Alternative payment models and innovation: a case study of US health system adoption of a sacubitril/valsartan to treat acute decompensated heart failure. J Med Econ. 2020 Dec; 23(12):1450-1460. Shafrin J, Aliyev ER, Brauer M, Park S, Shen X. PMID: 32945737.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    30. Crizanlizumab and comparators for adults with sickle cell disease: a systematic review and network meta-analysis. BMJ Open. 2020 09 17; 10(9):e034147. Thom H, Jansen J, Shafrin J, Zhao L, Joseph G, Cheng HY, Gupta S, Shah N. PMID: 32948541; PMCID: PMC7500297.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    31. Modeling the impact of patient treatment preference on health outcomes in relapsing-remitting multiple sclerosis. J Med Econ. 2020 May; 23(5):474-483. van Eijndhoven E, Brauer M, Kee R, MacEwan J, Mucha L, Wong SL, Durand A, Shafrin J. PMID: 31903813.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    32. A Flexible Open-Source Decision Model for Value Assessment of Biologic Treatment for Rheumatoid Arthritis. Pharmacoeconomics. 2019 06; 37(6):829-843. Incerti D, Curtis JR, Shafrin J, Lakdawalla DN, Jansen JP. PMID: 30737711.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    33. Using Information on Patient Adherence to Antipsychotic Medication to Understand Their Adherence to Other Medications. P T. 2019 Jun; 44(6):350-357. Shafrin J, Silverstein AR, MacEwan JP, Lakdawalla DN, Hatch A, Forma FM. PMID: 31160870; PMCID: PMC6534179.
      View in: PubMed   Mentions: 2  
    34. The economic burden of switching targeted disease-modifying anti-rheumatic drugs among rheumatoid arthritis patients. J Med Econ. 2019 Apr; 22(4):350-358. Shahabi A, Shafrin J, Zhao L, Green S, Curtice T, Marshall A, Paul D. PMID: 30653389.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    35. Does knowledge of patient non-compliance change prescribing behavior in the real world? A claims-based analysis of patients with serious mental illness. Clinicoecon Outcomes Res. 2018; 10:573-585. Shafrin J, Bognar K, Everson K, Brauer M, Lakdawalla DN, Forma FM. PMID: 30323635; PMCID: PMC6173173.
      View in: PubMed   Mentions: 6  
    36. The potential value of rapid, cloud-enabled onsite testing for the diagnosis of rheumatoid arthritis in the United States. J Med Econ. 2018 Nov; 21(11):1057-1066. Bognar K, Shafrin J, Brauer M, Zhao L, Hockett R, O'Neil M, Jena A. PMID: 30019600.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    37. Medication Adherence Patterns Among Patients with Multiple Serious Mental and Physical Illnesses. Adv Ther. 2018 May; 35(5):671-685. MacEwan JP, Silverstein AR, Shafrin J, Lakdawalla DN, Hatch A, Forma FM. PMID: 29725982; PMCID: PMC5960492.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    38. An exploratory case study of the impact of expanding cost-effectiveness analysis for second-line nivolumab for patients with squamous non-small cell lung cancer in Canada: Does it make a difference? Health Policy. 2018 06; 122(6):607-613. Shafrin J, Skornicki M, Brauer M, Villeneuve J, Lees M, Hertel N, Penrod JR, Jansen J. PMID: 29731176.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    39. Estimated prevalence of undiagnosed atrial fibrillation in the United States. PLoS One. 2018; 13(4):e0195088. Turakhia MP, Shafrin J, Bognar K, Trocio J, Abdulsattar Y, Wiederkehr D, Goldman DP. PMID: 29649277; PMCID: PMC5896911.
      View in: PubMed   Mentions: 73     Fields:    Translation:Humans
    40. Long-Term Health and Economic Value of Improved Mobility among Older Adults in the United States. Value Health. 2018 07; 21(7):792-798. Kabiri M, Brauer M, Shafrin J, Sullivan J, Gill TM, Goldman DP. PMID: 30005751; PMCID: PMC6078098.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    41. The effect of medication nonadherence on progression-free survival among patients with renal cell carcinoma. Cancer Manag Res. 2017; 9:731-739. Shafrin J, Sullivan J, Chou JW, Neely MN, Doan JF, Maclean JR. PMID: 29238223; PMCID: PMC5713701.
      View in: PubMed   Mentions: 7  
    42. The association between observed mobility and quality of life in the near elderly. PLoS One. 2017; 12(8):e0182920. Shafrin J, Sullivan J, Goldman DP, Gill TM. PMID: 28827806; PMCID: PMC5572211.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    43. The Economic Burden of ACPA-Positive Status Among Patients with Rheumatoid Arthritis. J Manag Care Spec Pharm. 2018 Jan; 24(1):4-11. Shafrin J, Tebeka MG, Price K, Patel C, Michaud K. PMID: 29290168; PMCID: PMC10398189.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    44. Access to credible information on schizophrenia patients' medication adherence by prescribers can change their treatment strategies: evidence from an online survey of providers. Patient Prefer Adherence. 2017; 11:1071-1081. Shafrin J, May SG, Shrestha A, Ruetsch C, Gerlanc N, Forma F, Hatch A, Lakdawalla DN, Lindenmayer JP. PMID: 28721020; PMCID: PMC5499864.
      View in: PubMed   Mentions: 8  
    45. Value-Based Payments and Incentives to Improve Care: A Case Study of Patients with Type 2 Diabetes in Medicare Advantage. Value Health. 2017 09; 20(8):1216-1220. Sussell J, Bognar K, Schwartz TT, Shafrin J, Sheehan JJ, Aubry W, Scanlon D. PMID: 28964455.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    46. Value Tools in Managed Care Decision Making: Current Hurdles and Future Opportunities. J Manag Care Spec Pharm. 2017 Jun; 23(6-a Suppl):S21-S27. Schafer J, Galante D, Shafrin J. PMID: 28535106; PMCID: PMC10408398.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    47. Predicting Real-World Effectiveness of Cancer Therapies Using Overall Survival and Progression-Free Survival from Clinical Trials: Empirical Evidence for the ASCO Value Framework. Value Health. 2017 Jul - Aug; 20(7):866-875. Lakdawalla DN, Shafrin J, Hou N, Peneva D, Vine S, Park J, Zhang J, Brookmeyer R, Figlin RA. PMID: 28712615.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    48. The cost of adherence mismeasurement in serious mental illness: a claims-based analysis. Am J Manag Care. 2017 May 01; 23(5):e156-e163. Shafrin J, Forma F, Scherer E, Hatch A, Vytlacil E, Lakdawalla D. PMID: 28810130.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    49. Patient Versus Physician Valuation of Durable Survival Gains: Implications for Value Framework Assessments. Value Health. 2017 02; 20(2):217-223. Shafrin J, Schwartz TT, Okoro T, Romley JA. PMID: 28237198.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    50. Geographic Variation in Diagnostic Ability and Quality of Care Metrics: A Case Study of Ankylosing Spondylitis and Low Back Pain. Inquiry. 2017 01 01; 54:46958017707873. Shafrin J, Griffith J, Shim JJ, Huber C, Ganguli A, Aubry W. PMID: 28548005; PMCID: PMC5798677.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    51. Geographic Variation in the Quality and Cost of Care for Patients with Rheumatoid Arthritis. J Manag Care Spec Pharm. 2016 Dec; 22(12):1472-1481. Shafrin J, Ganguli A, Gonzalez YS, Shim JJ, Seabury SA. PMID: 27882832; PMCID: PMC10398269.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    52. Estimating the Value of New Technologies That Provide More Accurate Drug Adherence Information to Providers for Their Patients with Schizophrenia. J Manag Care Spec Pharm. 2016 Nov; 22(11):1285-1291. Shafrin J, Schwartz TT, Lakdawalla DN, Forma FM. PMID: 27783545; PMCID: PMC10397938.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    53. Patterns of Adherence to Oral Atypical Antipsychotics Among Patients Diagnosed with Schizophrenia. J Manag Care Spec Pharm. 2016 Nov; 22(11):1349-1361. MacEwan JP, Forma FM, Shafrin J, Hatch A, Lakdawalla DN, Lindenmayer JP. PMID: 27783548; PMCID: PMC10397601.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    54. Evaluating Matching-Adjusted Indirect Comparisons in Practice: A Case Study of Patients with Attention-Deficit/Hyperactivity Disorder. Health Econ. 2017 11; 26(11):1459-1466. Shafrin J, Shrestha A, Chandra A, Erder MH, Sikirica V. PMID: 27620206.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    55. Utility of Cancer Value Frameworks for Patients, Payers, and Physicians. JAMA. 2016 May 17; 315(19):2069-70. Chandra A, Shafrin J, Dhawan R. PMID: 27187295.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    56. Physician and Patient Preferences for Nonvalvular Atrial Fibrillation Therapies. Value Health. 2016 06; 19(4):451-9. Shafrin J, Bruno A, MacEwan JP, Campinha-Bacote A, Trocio J, Shah M, Tan W, Romley JA. PMID: 27325337.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    57. The value of surrogate endpoints for predicting real-world survival across five cancer types. Curr Med Res Opin. 2016; 32(4):731-9. Shafrin J, Brookmeyer R, Peneva D, Park J, Zhang J, Figlin RA, Lakdawalla DN. PMID: 26743800.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    58. Economic Burden of Undiagnosed Nonvalvular Atrial Fibrillation in the United States. Am J Cardiol. 2015 Sep 01; 116(5):733-9. Turakhia MP, Shafrin J, Bognar K, Goldman DP, Mendys PM, Abdulsattar Y, Wiederkehr D, Trocio J. PMID: 26138378.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    59. Quality-adjusted cost of care: a meaningful way to measure growth in innovation cost versus the value of health gains. Health Aff (Millwood). 2015 Apr; 34(4):555-61. Lakdawalla D, Shafrin J, Lucarelli C, Nicholson S, Khan ZM, Philipson TJ. PMID: 25847636; PMCID: PMC4406284.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    60. Regional Growth in Medicare Spending, 1992-2010. Health Serv Res. 2015 Oct; 50(5):1574-88. Chicklis C, MaCurdy T, Bhattacharya J, Shafrin J, Zaidi S, Rogers D. PMID: 25676603; PMCID: PMC4600362.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    61. Methodological Assessment of Matching-Adjusted Indirect Comparisons: Case Study Application To Attention Deficit/Hyperactivity Disorder (Adhd). Value Health. 2014 Nov; 17(7):A579. Shafrin J, Sikirica V, Shrestha A, Henkhaus LE, Erder MH, Chandra A. PMID: 27201950.
      View in: PubMed   Mentions:    Fields:    
    62. Operating on commission: analyzing how physician financial incentives affect surgery rates. Health Econ. 2010 May; 19(5):562-80. Shafrin J. PMID: 19399752.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    63. Delivering vaccines: a case study of the distribution system of Vaccines for Children. Am J Manag Care. 2009 Oct; 15(10):751-4. Shafrin JT, Fontanesi JM. PMID: 19845427.
      View in: PubMed   Mentions:    Fields:    
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