Constanza Cortes

Title(s)Assistant Professor of Gerontology
SchoolSchool of Gerontology
AddressGER 346B
University Park Campus
Los Angeles CA 90089
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Activation of the muscle-to-brain axis ameliorates neurocognitive deficits in an Alzheimer's disease mouse model via enhancing neurotrophic and synaptic signaling. Geroscience. 2024 Sep 13. Taha HB, Birnbaum A, Matthews I, Aceituno K, Leon J, Thorwald M, Godoy-Lugo J, Cortes CJ. PMID: 39269584.
      View in: PubMed   Mentions:    Fields:    
    2. Evaluation of altered cell-cell communication between glia and neurons in the hippocampus of 3xTg-AD mice at two time points. bioRxiv. 2024 May 23. Soelter TM, Howton TC, Wilk EJ, Whitlock JH, Clark AD, Birnbaum A, Patterson DC, Cortes CJ, Lasseigne BN. PMID: 38826305; PMCID: PMC11142088.
      View in: PubMed   Mentions:
    3. Skeletal muscle TFEB signaling promotes central nervous system function and reduces neuroinflammation during aging and neurodegenerative disease. Cell Rep. 2023 11 28; 42(11):113436. Matthews I, Birnbaum A, Gromova A, Huang AW, Liu K, Liu EA, Coutinho K, McGraw M, Patterson DC, Banks MT, Nobles AC, Nguyen N, Merrihew GE, Wang L, Baeuerle E, Fernandez E, Musi N, MacCoss MJ, Miranda HC, La Spada AR, Cortes CJ. PMID: 37952157; PMCID: PMC10841857.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    4. X-linked SBMA model mice display relevant non-neurological phenotypes and their expression of mutant androgen receptor protein in motor neurons is not required for neuromuscular disease. Acta Neuropathol Commun. 2023 06 02; 11(1):90. Gromova A, Cha B, Robinson EM, Strickland LM, Nguyen N, ElMallah MK, Cortes CJ, La Spada AR. PMID: 37269008; PMCID: PMC10239133.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Editorial: Systemic implications of Alzheimer's disease. Front Aging Neurosci. 2023; 15:1219987. Cortes CJ, Thyfault JP, Wilkins HM. PMID: 37287872; PMCID: PMC10242176.
      View in: PubMed   Mentions:
    6. Gene therapy with AR isoform 2 rescues spinal and bulbar muscular atrophy phenotype by modulating AR transcriptional activity. Sci Adv. 2021 08; 7(34). Lim WF, Forouhan M, Roberts TC, Dabney J, Ellerington R, Speciale AA, Manzano R, Lieto M, Sangha G, Banerjee S, Conceição M, Cravo L, Biscans A, Roux L, Pourshafie N, Grunseich C, Duguez S, Khvorova A, Pennuto M, Cortes CJ, La Spada AR, Fischbeck KH, Wood MJA, Rinaldi C. PMID: 34417184; PMCID: PMC8378820.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    7. Low-Cost Gait Analysis for Behavioral Phenotyping of Mouse Models of Neuromuscular Disease. J Vis Exp. 2019 07 18; (149). Wertman V, Gromova A, La Spada AR, Cortes CJ. PMID: 31380846; PMCID: PMC7553151.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    8. TFEB dysregulation as a driver of autophagy dysfunction in neurodegenerative disease: Molecular mechanisms, cellular processes, and emerging therapeutic opportunities. Neurobiol Dis. 2019 02; 122:83-93. Cortes CJ, La Spada AR. PMID: 29852219; PMCID: PMC6291370.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimals
    9. X-Linked Spinal and Bulbar Muscular Atrophy: From Clinical Genetic Features and Molecular Pathology to Mechanisms Underlying Disease Toxicity. Adv Exp Med Biol. 2018; 1049:103-133. Cortes CJ, La Spada AR. PMID: 29427100.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    10. Transcriptional regulation of core autophagy and lysosomal genes by the androgen receptor promotes prostate cancer progression. Autophagy. 2017 Mar 04; 13(3):506-521. Blessing AM, Rajapakshe K, Reddy Bollu L, Shi Y, White MA, Pham AH, Lin C, Jonsson P, Cortes CJ, Cheung E, La Spada AR, Bast RC, Merchant FA, Coarfa C, Frigo DE. PMID: 27977328; PMCID: PMC5361609.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    11. Nemo-like kinase is a novel regulator of spinal and bulbar muscular atrophy. Elife. 2015 Aug 26; 4:e08493. Todd TW, Kokubu H, Miranda HC, Cortes CJ, La Spada AR, Lim J. PMID: 26308581; PMCID: PMC4577982.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    12. Autophagy in polyglutamine disease: Imposing order on disorder or contributing to the chaos? Mol Cell Neurosci. 2015 May; 66(Pt A):53-61. Cortes CJ, La Spada AR. PMID: 25771431; PMCID: PMC4449833.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    13. Motor neuron degeneration in spinal and Bulbar Muscular Atrophy is a skeletal muscle-driven process: Relevance to therapy development and implications for related motor neuron diseases. Rare Dis. 2014; 2(1):e962402. Cortes CJ, La Spada AR. PMID: 26942099; PMCID: PMC4755247.
      View in: PubMed   Mentions: 4  
    14. Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA. Nat Neurosci. 2014 Sep; 17(9):1180-9. Cortes CJ, Miranda HC, Frankowski H, Batlevi Y, Young JE, Le A, Ivanov N, Sopher BL, Carromeu C, Muotri AR, Garden GA, La Spada AR. PMID: 25108912; PMCID: PMC4180729.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansAnimalsCells
    15. Muscle expression of mutant androgen receptor accounts for systemic and motor neuron disease phenotypes in spinal and bulbar muscular atrophy. Neuron. 2014 Apr 16; 82(2):295-307. Cortes CJ, Ling SC, Guo LT, Hung G, Tsunemi T, Ly L, Tokunaga S, Lopez E, Sopher BL, Bennett CF, Shelton GD, Cleveland DW, La Spada AR. PMID: 24742458; PMCID: PMC4096235.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansAnimalsCells
    16. Peripheral androgen receptor gene suppression rescues disease in mouse models of spinal and bulbar muscular atrophy. Cell Rep. 2014 May 08; 7(3):774-84. Lieberman AP, Yu Z, Murray S, Peralta R, Low A, Guo S, Yu XX, Cortes CJ, Bennett CF, Monia BP, La Spada AR, Hung G. PMID: 24746732; PMCID: PMC4356525.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimalsCells
    17. The many faces of autophagy dysfunction in Huntington's disease: from mechanism to therapy. Drug Discov Today. 2014 Jul; 19(7):963-71. Cortes CJ, La Spada AR. PMID: 24632005; PMCID: PMC4096219.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimals
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