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Constanza Cortes

Title(s)Assistant Professor of Gerontology
SchoolSchool of Gerontology
AddressGER 346B
University Park Campus
Los Angeles CA 90089
Phone+1 213 764 8823
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. From dark horse to front-runner: vascular contributions to brain health : Proceedings of the 2022 annual workshop of the Albert research institute for white matter and cognition. Geroscience. 2025 Aug 30. Gupta A, Pires PW, Billinger SA, Carmichael ST, Cortes CJ, Daneman R, Hu X, Kaufer D, Levendovszky SR, Sorond FA, Stillman CM, Tarantini S, Wilcock DM, Williamson JD, Yabluchanskiy A, Elahi F, Zuloaga KL. PMID: 40883628.
      View in: PubMed   Mentions:    Fields:    
    2. Convergent skeletal muscle cytokine responses to TFEB overexpression and voluntary wheel running reflect sex-based variability to exercise adaptations in mice. Physiol Rep. 2025 Aug; 13(16):e70519. Patterson DC, Birnbaum A, Matthews I, Cortes CJ. PMID: 40834288; PMCID: PMC12367098.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    3. Convergent Skeletal Muscle Cytokine Responses to TFEB Overexpression and Voluntary Wheel Running Reflect Sex-Based Variability in Exercise Adaptations. bioRxiv. 2025 May 28. Patterson DC, Birnbaum A, Matthews I, Cortes CJ. PMID: 40502167; PMCID: PMC12154895.
      View in: PubMed   Mentions:
    4. Skeletal muscle TFEB overexpression does not increase neurogenesis markers in the young female hippocampus. MicroPubl Biol. 2025; 2025. Hakian M, Matthews I, Cortes CJ. PMID: 40401150; PMCID: PMC12093156.
      View in: PubMed   Mentions:
    5. Evaluation of altered cell-cell communication between glia and neurons in the hippocampus of 3xTg-AD mice at two time points. J Cell Commun Signal. 2025 Mar; 19(1):e70006. Soelter TM, Howton TC, Wilk EJ, Whitlock JH, Clark AD, Birnbaum A, Patterson DC, Cortes CJ, Lasseigne BN. PMID: 40026671; PMCID: PMC11870853.
      View in: PubMed   Mentions:
    6. Evaluation of altered cell-cell communication between glia and neurons in the hippocampus of 3xTg-AD mice at two time points. bioRxiv. 2024 Sep 19. Soelter TM, Howton TC, Wilk EJ, Whitlock JH, Clark AD, Birnbaum A, Patterson DC, Cortes CJ, Lasseigne BN. PMID: 38826305; PMCID: PMC11142088.
      View in: PubMed   Mentions:
    7. Activation of the muscle-to-brain axis ameliorates neurocognitive deficits in an Alzheimer's disease mouse model via enhancing neurotrophic and synaptic signaling. Geroscience. 2025 Apr; 47(2):1593-1613. Taha HB, Birnbaum A, Matthews I, Aceituno K, Leon J, Thorwald M, Godoy-Lugo J, Cortes CJ. PMID: 39269584; PMCID: PMC11978596.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    8. Skeletal muscle TFEB signaling promotes central nervous system function and reduces neuroinflammation during aging and neurodegenerative disease. Cell Rep. 2023 11 28; 42(11):113436. Matthews I, Birnbaum A, Gromova A, Huang AW, Liu K, Liu EA, Coutinho K, McGraw M, Patterson DC, Banks MT, Nobles AC, Nguyen N, Merrihew GE, Wang L, Baeuerle E, Fernandez E, Musi N, MacCoss MJ, Miranda HC, La Spada AR, Cortes CJ. PMID: 37952157; PMCID: PMC10841857.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    9. X-linked SBMA model mice display relevant non-neurological phenotypes and their expression of mutant androgen receptor protein in motor neurons is not required for neuromuscular disease. Acta Neuropathol Commun. 2023 06 02; 11(1):90. Gromova A, Cha B, Robinson EM, Strickland LM, Nguyen N, ElMallah MK, Cortes CJ, La Spada AR. PMID: 37269008; PMCID: PMC10239133.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    10. Editorial: Systemic implications of Alzheimer's disease. Front Aging Neurosci. 2023; 15:1219987. Cortes CJ, Thyfault JP, Wilkins HM. PMID: 37287872; PMCID: PMC10242176.
      View in: PubMed   Mentions:
    11. Precision Exercise Medicine: Sex Specific Differences in Immune and CNS Responses to Physical Activity. Brain Plast. 2022; 8(1):65-77. Cortes CJ, De Miguel Z. PMID: 36448044; PMCID: PMC9661359.
      View in: PubMed   Mentions: 15  
    12. Reuniting the Body "Neck Up and Neck Down" to Understand Cognitive Aging: The Nexus of Geroscience and Neuroscience. J Gerontol A Biol Sci Med Sci. 2022 01 07; 77(1):e1-e9. Hernandez AR, Hoffman JM, Hernandez CM, Cortes CJ, Jumbo-Lucioni P, Baxter MG, Esser KA, Liu AC, McMahon LL, Bizon JL, Burke SN, Buford TW, Carter CS. PMID: 34309630; PMCID: PMC8751793.
      View in: PubMed   Mentions: 5     Fields:    
    13. Gene therapy with AR isoform 2 rescues spinal and bulbar muscular atrophy phenotype by modulating AR transcriptional activity. Sci Adv. 2021 08; 7(34). Lim WF, Forouhan M, Roberts TC, Dabney J, Ellerington R, Speciale AA, Manzano R, Lieto M, Sangha G, Banerjee S, Conceição M, Cravo L, Biscans A, Roux L, Pourshafie N, Grunseich C, Duguez S, Khvorova A, Pennuto M, Cortes CJ, La Spada AR, Fischbeck KH, Wood MJA, Rinaldi C. PMID: 34417184; PMCID: PMC8378820.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    14. Forgot to Exercise? Exercise Derived Circulating Myokines in Alzheimer's Disease: A Perspective. Front Neurol. 2021; 12:649452. Gupta R, Khan R, Cortes CJ. PMID: 34276532; PMCID: PMC8278015.
      View in: PubMed   Mentions: 19  
    15. Women in neuroscience special issue: Pandemic edition. J Neurosci Res. 2021 01; 99(1):5-6. Cortes CJ. PMID: 32924227.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    16. Interactions with PDZ proteins diversify voltage-gated calcium channel signaling. J Neurosci Res. 2021 01; 99(1):332-348. Wang S, Cortes CJ. PMID: 32476168.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    17. Low-Cost Gait Analysis for Behavioral Phenotyping of Mouse Models of Neuromuscular Disease. J Vis Exp. 2019 07 18; (149). Wertman V, Gromova A, La Spada AR, Cortes CJ. PMID: 31380846; PMCID: PMC7553151.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    18. Challenges in IBD Research: Preclinical Human IBD Mechanisms. Inflamm Bowel Dis. 2019 05 16; 25(Suppl 2):S5-S12. Pizarro TT, Stappenbeck TS, Rieder F, Rosen MJ, Colombel JF, Donowitz M, Towne J, Mazmanian SK, Faith JJ, Hodin RA, Garrett WS, Fichera A, Poritz LS, Cortes CJ, Shtraizent N, Honig G, Snapper SB, Hurtado-Lorenzo A, Salzman NH, Chang EB. PMID: 31095706.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimals
    19. TFEB dysregulation as a driver of autophagy dysfunction in neurodegenerative disease: Molecular mechanisms, cellular processes, and emerging therapeutic opportunities. Neurobiol Dis. 2019 02; 122:83-93. Cortes CJ, La Spada AR. PMID: 29852219; PMCID: PMC6291370.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimals
    20. X-Linked Spinal and Bulbar Muscular Atrophy: From Clinical Genetic Features and Molecular Pathology to Mechanisms Underlying Disease Toxicity. Adv Exp Med Biol. 2018; 1049:103-133. Cortes CJ, La Spada AR. PMID: 29427100.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    21. Transcriptional regulation of core autophagy and lysosomal genes by the androgen receptor promotes prostate cancer progression. Autophagy. 2017 Mar 04; 13(3):506-521. Blessing AM, Rajapakshe K, Reddy Bollu L, Shi Y, White MA, Pham AH, Lin C, Jonsson P, Cortes CJ, Cheung E, La Spada AR, Bast RC, Merchant FA, Coarfa C, Frigo DE. PMID: 27977328; PMCID: PMC5361609.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    22. Nemo-like kinase is a novel regulator of spinal and bulbar muscular atrophy. Elife. 2015 Aug 26; 4:e08493. Todd TW, Kokubu H, Miranda HC, Cortes CJ, La Spada AR, Lim J. PMID: 26308581; PMCID: PMC4577982.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    23. Autophagy in polyglutamine disease: Imposing order on disorder or contributing to the chaos? Mol Cell Neurosci. 2015 May; 66(Pt A):53-61. Cortes CJ, La Spada AR. PMID: 25771431; PMCID: PMC4449833.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    24. Motor neuron degeneration in spinal and Bulbar Muscular Atrophy is a skeletal muscle-driven process: Relevance to therapy development and implications for related motor neuron diseases. Rare Dis. 2014; 2(1):e962402. Cortes CJ, La Spada AR. PMID: 26942099; PMCID: PMC4755247.
      View in: PubMed   Mentions: 4  
    25. Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA. Nat Neurosci. 2014 Sep; 17(9):1180-9. Cortes CJ, Miranda HC, Frankowski H, Batlevi Y, Young JE, Le A, Ivanov N, Sopher BL, Carromeu C, Muotri AR, Garden GA, La Spada AR. PMID: 25108912; PMCID: PMC4180729.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansAnimalsCells
    26. Peripheral androgen receptor gene suppression rescues disease in mouse models of spinal and bulbar muscular atrophy. Cell Rep. 2014 May 08; 7(3):774-84. Lieberman AP, Yu Z, Murray S, Peralta R, Low A, Guo S, Yu XX, Cortes CJ, Bennett CF, Monia BP, La Spada AR, Hung G. PMID: 24746732; PMCID: PMC4356525.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansAnimalsCells
    27. Muscle expression of mutant androgen receptor accounts for systemic and motor neuron disease phenotypes in spinal and bulbar muscular atrophy. Neuron. 2014 Apr 16; 82(2):295-307. Cortes CJ, Ling SC, Guo LT, Hung G, Tsunemi T, Ly L, Tokunaga S, Lopez E, Sopher BL, Bennett CF, Shelton GD, Cleveland DW, La Spada AR. PMID: 24742458; PMCID: PMC4096235.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansAnimalsCells
    28. The many faces of autophagy dysfunction in Huntington's disease: from mechanism to therapy. Drug Discov Today. 2014 Jul; 19(7):963-71. Cortes CJ, La Spada AR. PMID: 24632005; PMCID: PMC4096219.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimals
    29. Rapamycin delays disease onset and prevents PrP plaque deposition in a mouse model of Gerstmann-Sträussler-Scheinker disease. J Neurosci. 2012 Sep 05; 32(36):12396-405. Cortes CJ, Qin K, Cook J, Solanki A, Mastrianni JA. PMID: 22956830; PMCID: PMC3752082.
      View in: PubMed   Mentions: 56     Fields:    Translation:Animals
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    NIH Funding Acknowledgment: Important - All publications resulting from the utilization of SC CTSI resources are required to credit the SC CTSI grant by including the NIH funding acknowledgment and must comply with the NIH Public Access Policy.

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