Biraj Mahato, PhD

Title(s)Assistant Professor of Research Ophthalmology
SchoolKeck School of Medicine of Usc
Address4640 West Sunset Blvd
Off Campus
Los Angeles CA 90027
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    Collapse Biography 
    Collapse Education and Training
    CSIR-Indian Institute of Chemical Biology (Jadavpur University), Kolkata, IndiaPhD2012
    University of Kansas Medical Center, Kansas City, KSPostdoctoral fellowship2014
    University of Pennsylvania, Philadelphia, PAPostdoctoral fellowship2015
    UNT Health Science Center, Fort Worth, TXPostdoctoral fellowship 2020
    Collapse Awards and Honors
    IIT2006Graduate Aptitude Test in Engineering (GATE)
    CSIR, Govt. of India2006CSIR-Junior Research Fellowship
    CSIR, Govt. of India 2008CSIR-Senior Research Fellowship
    CSIR-IICB2010Travel award to Gordon Research Conference
    2018Cell Symposium Support Award
    Glaucoma Research Foundation2019Grant award

    Collapse Overview 
    Collapse Overview
    Dr. Biraj Mahato earned his PhD in Molecular and Cellular Biology from the CSIR-Indian Institute of Chemical Biology (Jadavpur University), India. He completed his postdoctoral training in Stem cell biology and Regenerative medicine from KU Medical Center, UPenn and UNT Health Science Center. Dr. Mahato has extensive expertise in diverse biological fields such as cellular reprogramming, stem cell biology, retinal regeneration, and mitochondrial biology. Dr. Mahato’s prior research demonstrated a facile small molecule-based method to obtain retinal photoreceptor like cells from skin fibroblasts. Strikingly, these chemically induced photoreceptors were shown to restore vision in blind animal models (rd1). Moreover, his research showed how mitochondrial function and cellular energy metabolism balances pluripotency in embryonic stem cells.

    Dr. Mahato’s laboratory currently focused on the following areas: (i) Development of novel regenerative cell-based therapies for ophthalmic neurodegenerative diseases. (ii) Molecular and functional analysis of photoreceptors (rod and cone) and retinal ganglion cells for their therapeutic application to cure blindness. (iii) In vivo retinal regeneration for visual function improvement. (iii) Translation of clinically observed correlations into a mechanistic understanding of the physical and biological underpinning of neurological disorders that affect both the retina and optic nerve.

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pharmacologic fibroblast reprogramming into photoreceptors restores vision. Nature. 2020 05; 581(7806):83-88. Mahato B, Kaya KD, Fan Y, Sumien N, Shetty RA, Zhang W, Davis D, Mock T, Batabyal S, Ni A, Mohanty S, Han Z, Farjo R, Forster MJ, Swaroop A, Chavala SH. PMID: 32376950; PMCID: PMC7469946.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    2. Inhibition of Noncanonical Murine Double Minute 2 Homolog Abrogates Ocular Inflammation through NF-κB Suppression. Am J Pathol. 2018 09; 188(9):2087-2096. Fan Y, Zhang W, Ni A, Mahato B, Chavala SH. PMID: 30126549; PMCID: PMC6854436.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    3. Regulation of mitochondrial function and cellular energy metabolism by protein kinase C-λ/ι: a novel mode of balancing pluripotency. Stem Cells. 2014 Nov; 32(11):2880-92. Mahato B, Home P, Rajendran G, Paul A, Saha B, Ganguly A, Ray S, Roy N, Swerdlow RH, Paul S. PMID: 25142417; PMCID: PMC4198455.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    4. Vesicular transport of a ribonucleoprotein to mitochondria. Biol Open. 2014 Oct 17; 3(11):1083-91. Mukherjee J, Mahato B, Adhya S. PMID: 25326515; PMCID: PMC4232766.
      View in: PubMed   Mentions:    Fields:    
    5. Inhibition of protein kinase C signaling maintains rat embryonic stem cell pluripotency. J Biol Chem. 2013 Aug 23; 288(34):24351-62. Rajendran G, Dutta D, Hong J, Paul A, Saha B, Mahato B, Ray S, Home P, Ganguly A, Weiss ML, Paul S. PMID: 23846691; PMCID: PMC3750137.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    6. Mitochondrial gene therapy: The tortuous path from bench to bedside. Mitochondrion. 2011 Nov; 11(6):839-44. Adhya S, Mahato B, Jash S, Koley S, Dhar G, Chowdhury T. PMID: 21704735.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    7. RNA-mediated restoration of mitochondrial function in cells harboring a Kearns Sayre Syndrome mutation. Mitochondrion. 2011 Jul; 11(4):564-74. Mahato B, Jash S, Adhya S. PMID: 21406250.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    8. Targeted mRNA degradation by complex-mediated delivery of antisense RNAs to intracellular human mitochondria. Hum Mol Genet. 2008 May 01; 17(9):1292-8. Mukherjee S, Mahata B, Mahato B, Adhya S. PMID: 18203752.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
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