Andrew Mellor

Title(s)Research Coordinator II
SchoolKeck School of Medicine of Usc
Address10182 Telesis Court, 3rd Floor
Off Campus
San Diego CA 92121
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. NUDCD3 deficiency disrupts V(D)J recombination to cause SCID and Omenn syndrome. Sci Immunol. 2024 May 24; 9(95):eade5705. Chen R, Lukianova E, van der Loeff IS, Spegarova JS, Willet JDP, James KD, Ryder EJ, Griffin H, IJspeert H, Gajbhiye A, Lamoliatte F, Marin-Rubio JL, Woodbine L, Lemos H, Swan DJ, Pintar V, Sayes K, Ruiz-Morales ER, Eastham S, Dixon D, Prete M, Prigmore E, Jeggo P, Boyes J, Mellor A, Huang L, van der Burg M, Engelhardt KR, Stray-Pedersen A, Erichsen HC, Gennery AR, Trost M, Adams DJ, Anderson G, Lorenc A, Trynka G, Hambleton S. PMID: 38787962.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Meningeal dendritic cells drive neuropathic pain through elevation of the kynurenine metabolic pathway in mice. J Clin Invest. 2022 12 01; 132(23). Maganin AG, Souza GR, Fonseca MD, Lopes AH, Guimarães RM, Dagostin A, Cecilio NT, Mendes AS, Gonçalves WA, Silva CE, Fernandes Gomes FI, Mauriz Marques LM, Silva RL, Arruda LM, Santana DA, Lemos H, Huang L, Davoli-Ferreira M, Santana-Coelho D, Sant'Anna MB, Kusuda R, Talbot J, Pacholczyk G, Buqui GA, Lopes NP, Alves-Filho JC, Leão RM, O'Connor JC, Cunha FQ, Mellor A, Cunha TM. PMID: 36227694; PMCID: PMC9711882.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    3. The immunotherapeutic role of indoleamine 2,3-dioxygenase in head and neck squamous cell carcinoma: A systematic review. Clin Otolaryngol. 2021 09; 46(5):919-934. Lin DJ, Ng JCK, Huang L, Robinson M, O'Hara J, Wilson JA, Mellor AL. PMID: 34053179; PMCID: PMC8600953.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    4. Indoleamine 2,3 dioxygenase, age, and immune activation in people living with HIV. J Investig Med. 2021 08; 69(6):1238-1244. Baer SL, Colombo RE, Johnson MH, Wakade S, Pacholczyk G, Newman-Whitlow C, Thompson SA, Saag MS, Martin JN, Floris-Moore M, Huang L, Mellor AL. PMID: 33875612; PMCID: PMC8319090.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    5. STING negatively regulates allogeneic T-cell responses by constraining antigen-presenting cell function. Cell Mol Immunol. 2021 03; 18(3):632-643. Wu Y, Tang CA, Mealer C, Bastian D, Hanief Sofi M, Tian L, Schutt S, Choi HJ, Ticer T, Zhang M, Sui X, Huang L, Mellor AL, Hu CA, Yu XZ. PMID: 33500563; PMCID: PMC8027033.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    6. Exosome-derived miR-142-5p remodels lymphatic vessels and induces IDO to promote immune privilege in the tumour microenvironment. Cell Death Differ. 2021 02; 28(2):715-729. Zhou C, Zhang Y, Yan R, Huang L, Mellor AL, Yang Y, Chen X, Wei W, Wu X, Yu L, Liang L, Zhang D, Wu S, Wang W. PMID: 32929219; PMCID: PMC7862304.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    7. Overcoming resistance to STING agonist therapy to incite durable protective antitumor immunity. J Immunother Cancer. 2020 08; 8(2). Lemos H, Ou R, McCardle C, Lin Y, Calver J, Minett J, Chadli A, Huang L, Mellor AL. PMID: 32847988; PMCID: PMC7451475.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    8. Co-treatments to Boost IDO Activity and Inhibit Production of Downstream Catabolites Induce Durable Suppression of Experimental Autoimmune Encephalomyelitis. Front Immunol. 2020; 11:1256. Lemos H, Mohamed E, Ou R, McCardle C, Zheng X, McGuire K, Homer NZM, Mole DJ, Huang L, Mellor AL. PMID: 32625215; PMCID: PMC7311583.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    9. CD40 Accelerates the Antigen-Specific Stem-Like Memory CD8+ T Cells Formation and Human Papilloma Virus (HPV)-Positive Tumor Eradication. Front Immunol. 2020; 11:1012. Zhang Y, Wang N, Ding M, Yang Y, Wang Z, Huang L, Zhu W, Mellor AL, Hou X, Zhou C, Yan R, Wang W, Wu S. PMID: 32536922; PMCID: PMC7267052.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    10. CD73 on cancer-associated fibroblasts enhanced by the A2B-mediated feedforward circuit enforces an immune checkpoint. Nat Commun. 2020 01 24; 11(1):515. Yu M, Guo G, Huang L, Deng L, Chang CS, Achyut BR, Canning M, Xu N, Arbab AS, Bollag RJ, Rodriguez PC, Mellor AL, Shi H, Munn DH, Cui Y. PMID: 31980601; PMCID: PMC6981126.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    11. Stimulator of interferon genes agonists attenuate type I diabetes progression in NOD mice. Immunology. 2019 12; 158(4):353-361. Lemos H, Mohamed E, Huang L, Chandler PR, Ou R, Pacholczyk R, Mellor AL. PMID: 31557322; PMCID: PMC6856934.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    12. A Validation Study on IDO Immune Biomarkers for Survival Prediction in Non-Small Cell Lung Cancer: Radiation Dose Fractionation Effect in Early-Stage Disease. Clin Cancer Res. 2020 01 01; 26(1):282-289. Wang W, Huang L, Jin JY, Pi W, Ellsworth SG, Jolly S, Mellor AL, Machtay M, Kong FS. PMID: 31471311.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    13. Limited Effect of Indolamine 2,3-Dioxygenase Expression and Enzymatic Activity on Lupus-Like Disease in B6.Nba2 Mice. Front Immunol. 2019; 10:2017. Davison LM, Liu JC, Huang L, Carroll TM, Mellor AL, Jørgensen TN. PMID: 31555267; PMCID: PMC6727869.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    14. Adoptive CD8+ T cell therapy against cancer:Challenges and opportunities. Cancer Lett. 2019 Oct 10; 462:23-32. Jiang X, Xu J, Liu M, Xing H, Wang Z, Huang L, Mellor AL, Wang W, Wu S. PMID: 31356845.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    15. Immune control by amino acid catabolism during tumorigenesis and therapy. Nat Rev Cancer. 2019 03; 19(3):162-175. Lemos H, Huang L, Prendergast GC, Mellor AL. PMID: 30696923.
      View in: PubMed   Mentions: 110     Fields:    Translation:HumansAnimals
    16. Metabolic requirements for expanding and arming a clone army. Nat Immunol. 2019 02; 20(2):118-120. Mellor AL, Huang L. PMID: 30664763.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    17. IDO Immune Status after Chemoradiation May Predict Survival in Lung Cancer Patients. Cancer Res. 2018 02 01; 78(3):809-816. Wang W, Huang L, Jin JY, Jolly S, Zang Y, Wu H, Yan L, Pi W, Li L, Mellor AL, Kong FS. PMID: 29118088; PMCID: PMC5811356.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    18. Indoleamine 2,3-Dioxygenase and Tolerance: Where Are We Now? Front Immunol. 2017; 8:1360. Mellor AL, Lemos H, Huang L. PMID: 29163470; PMCID: PMC5663846.
      View in: PubMed   Mentions: 95     Fields:    
    19. Carbidopa, a drug in use for management of Parkinson disease inhibits T cell activation and autoimmunity. PLoS One. 2017; 12(9):e0183484. Zhu H, Lemos H, Bhatt B, Islam BN, Singh A, Gurav A, Huang L, Browning DD, Mellor A, Fulzele S, Singh N. PMID: 28898256; PMCID: PMC5595290.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    20. Virus Infections Incite Pain Hypersensitivity by Inducing Indoleamine 2,3 Dioxygenase. PLoS Pathog. 2016 05; 12(5):e1005615. Huang L, Ou R, Rabelo de Souza G, Cunha TM, Lemos H, Mohamed E, Li L, Pacholczyk G, Randall J, Munn DH, Mellor AL. PMID: 27168185; PMCID: PMC4863962.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    21. STING Promotes the Growth of Tumors Characterized by Low Antigenicity via IDO Activation. Cancer Res. 2016 04 15; 76(8):2076-81. Lemos H, Mohamed E, Huang L, Ou R, Pacholczyk G, Arbab AS, Munn D, Mellor AL. PMID: 26964621; PMCID: PMC4873329.
      View in: PubMed   Mentions: 147     Fields:    Translation:AnimalsCells
    22. The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment. Sci Adv. 2015 Nov; 1(10):e1500845. Sharma MD, Shinde R, McGaha TL, Huang L, Holmgaard RB, Wolchok JD, Mautino MR, Celis E, Sharpe AH, Francisco LM, Powell JD, Yagita H, Mellor AL, Blazar BR, Munn DH. PMID: 26601142; PMCID: PMC4640592.
      View in: PubMed   Mentions: 96     Fields:    
    23. Amino acid metabolism inhibits antibody-driven kidney injury by inducing autophagy. J Immunol. 2015 Jun 15; 194(12):5713-24. Chaudhary K, Shinde R, Liu H, Gnana-Prakasam JP, Veeranan-Karmegam R, Huang L, Ravishankar B, Bradley J, Kvirkvelia N, McMenamin M, Xiao W, Kleven D, Mellor AL, Madaio MP, McGaha TL. PMID: 25980011; PMCID: PMC4458436.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    24. STING, nanoparticles, autoimmune disease and cancer: a novel paradigm for immunotherapy? Expert Rev Clin Immunol. 2015 Jan; 11(1):155-65. Lemos H, Huang L, McGaha T, Mellor AL. PMID: 25521938; PMCID: PMC4387570.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    25. Cytosolic DNA sensing via the stimulator of interferon genes adaptor: Yin and Yang of immune responses to DNA. Eur J Immunol. 2014 Oct; 44(10):2847-53. Lemos H, Huang L, McGaha TL, Mellor AL. PMID: 25143264; PMCID: PMC4197080.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    26. Activation of the STING adaptor attenuates experimental autoimmune encephalitis. J Immunol. 2014 Jun 15; 192(12):5571-8. Lemos H, Huang L, Chandler PR, Mohamed E, Souza GR, Li L, Pacholczyk G, Barber GN, Hayakawa Y, Munn DH, Mellor AL. PMID: 24799564; PMCID: PMC4086255.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    27. Immunosuppressive myeloid cells induced by chemotherapy attenuate antitumor CD4+ T-cell responses through the PD-1-PD-L1 axis. Cancer Res. 2014 Jul 01; 74(13):3441-53. Ding ZC, Lu X, Yu M, Lemos H, Huang L, Chandler P, Liu K, Walters M, Krasinski A, Mack M, Blazar BR, Mellor AL, Munn DH, Zhou G. PMID: 24780756; PMCID: PMC4079842.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    28. Indoleamine 2,3-dioxygenase (IDO) activity during the primary immune response to influenza infection modifies the memory T cell response to influenza challenge. Viral Immunol. 2014 Apr; 27(3):112-23. Sage LK, Fox JM, Mellor AL, Tompkins SM, Tripp RA. PMID: 24702331; PMCID: PMC3995207.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    29. Marginal zone CD169+ macrophages coordinate apoptotic cell-driven cellular recruitment and tolerance. Proc Natl Acad Sci U S A. 2014 Mar 18; 111(11):4215-20. Ravishankar B, Shinde R, Liu H, Chaudhary K, Bradley J, Lemos HP, Chandler P, Tanaka M, Munn DH, Mellor AL, McGaha TL. PMID: 24591636; PMCID: PMC3964059.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    30. Metabolic control of tumour progression and antitumour immunity. Curr Opin Oncol. 2014 Jan; 26(1):92-9. Huang L, Mellor AL. PMID: 24305570; PMCID: PMC4017202.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    31. GCN2-dependent metabolic stress is essential for endotoxemic cytokine induction and pathology. Mol Cell Biol. 2014 Feb; 34(3):428-38. Liu H, Huang L, Bradley J, Liu K, Bardhan K, Ron D, Mellor AL, Munn DH, McGaha TL. PMID: 24248597; PMCID: PMC3911502.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    32. Cutting edge: DNA sensing via the STING adaptor in myeloid dendritic cells induces potent tolerogenic responses. J Immunol. 2013 Oct 01; 191(7):3509-13. Huang L, Li L, Lemos H, Chandler PR, Pacholczyk G, Baban B, Barber GN, Hayakawa Y, McGaha TL, Ravishankar B, Munn DH, Mellor AL. PMID: 23986532; PMCID: PMC3788571.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    33. Induction and role of indoleamine 2,3 dioxygenase in mouse models of influenza a virus infection. PLoS One. 2013; 8(6):e66546. Huang L, Li L, Klonowski KD, Tompkins SM, Tripp RA, Mellor AL. PMID: 23785507; PMCID: PMC3681773.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    34. An inherently bifunctional subset of Foxp3+ T helper cells is controlled by the transcription factor eos. Immunity. 2013 May 23; 38(5):998-1012. Sharma MD, Huang L, Choi JH, Lee EJ, Wilson JM, Lemos H, Pan F, Blazar BR, Pardoll DM, Mellor AL, Shi H, Munn DH. PMID: 23684987; PMCID: PMC3681093.
      View in: PubMed   Mentions: 95     Fields:    Translation:AnimalsCells
    35. Local administration of TLR ligands rescues the function of tumor-infiltrating CD8 T cells and enhances the antitumor effect of lentivector immunization. J Immunol. 2013 Jun 01; 190(11):5866-73. Xiao H, Peng Y, Hong Y, Huang L, Guo ZS, Bartlett DL, Fu N, Munn DH, Mellor A, He Y. PMID: 23610140; PMCID: PMC3660440.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    36. Inhibition of indoleamine 2,3-dioxygenase enhances the T-cell response to influenza virus infection. J Gen Virol. 2013 Jul; 94(Pt 7):1451-1461. Fox JM, Sage LK, Huang L, Barber J, Klonowski KD, Mellor AL, Tompkins SM, Tripp RA. PMID: 23580425; PMCID: PMC3709631.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    37. B7h (ICOS-L) maintains tolerance at the fetomaternal interface. Am J Pathol. 2013 Jun; 182(6):2204-13. Riella LV, Dada S, Chabtini L, Smith B, Huang L, Dakle P, Mfarrej B, D'Addio F, Adams LT, Kochupurakkal N, Vergani A, Fiorina P, Mellor AL, Sharpe AH, Yagita H, Guleria I. PMID: 23578385; PMCID: PMC3668017.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    38. Constitutively CD40-activated B cells regulate CD8 T cell inflammatory response by IL-10 induction. J Immunol. 2013 Apr 01; 190(7):3189-96. Koni PA, Bolduc A, Takezaki M, Ametani Y, Huang L, Lee JR, Nutt SL, Kamanaka M, Flavell RA, Mellor AL, Tsubata T, Shimoda M. PMID: 23440421; PMCID: PMC3608804.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    39. Amino acid catabolism: a pivotal regulator of innate and adaptive immunity. Immunol Rev. 2012 Sep; 249(1):135-57. McGaha TL, Huang L, Lemos H, Metz R, Mautino M, Prendergast GC, Mellor AL. PMID: 22889220; PMCID: PMC4384693.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansAnimals
    40. Polyfunctional CD4⁺ T cells are essential for eradicating advanced B-cell lymphoma after chemotherapy. Blood. 2012 Sep 13; 120(11):2229-39. Ding ZC, Huang L, Blazar BR, Yagita H, Mellor AL, Munn DH, Zhou G. PMID: 22859605; PMCID: PMC3447781.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCellsPHPublic Health
    41. Altered tryptophan metabolism as a paradigm for good and bad aspects of immune privilege in chronic inflammatory diseases. Front Immunol. 2012; 3:109. Li L, Huang L, Lemos HP, Mautino M, Mellor AL. PMID: 22593757; PMCID: PMC3350084.
      View in: PubMed   Mentions: 7     Fields:    
    42. Engineering DNA nanoparticles as immunomodulatory reagents that activate regulatory T cells. J Immunol. 2012 May 15; 188(10):4913-20. Huang L, Lemos HP, Li L, Li M, Chandler PR, Baban B, McGaha TL, Ravishankar B, Lee JR, Munn DH, Mellor AL. PMID: 22516958; PMCID: PMC3349160.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    43. Physiologic control of IDO competence in splenic dendritic cells. J Immunol. 2011 Sep 01; 187(5):2329-35. Baban B, Chandler PR, Johnson BA, Huang L, Li M, Sharpe ML, Francisco LM, Sharpe AH, Blazar BR, Munn DH, Mellor AL. PMID: 21813777; PMCID: PMC3556270.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    44. Dendritic cells, indoleamine 2,3 dioxygenase and acquired immune privilege. Int Rev Immunol. 2010 Apr; 29(2):133-55. Huang L, Baban B, Johnson BA, Mellor AL. PMID: 20367139; PMCID: PMC3671384.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    45. CD4(+)CD25(+) regulatory T cells resist a novel form of CD28- and Fas-dependent p53-induced T cell apoptosis. J Immunol. 2010 Jan 01; 184(1):94-104. Singh N, Yamamoto M, Takami M, Seki Y, Takezaki M, Mellor AL, Iwashima M. PMID: 19949106; PMCID: PMC4436589.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    46. Inducing the tryptophan catabolic pathway, indoleamine 2,3-dioxygenase (IDO), for suppression of graft-versus-host disease (GVHD) lethality. Blood. 2009 Dec 03; 114(24):5062-70. Jasperson LK, Bucher C, Panoskaltsis-Mortari A, Mellor AL, Munn DH, Blazar BR. PMID: 19828695; PMCID: PMC2788979.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    47. IFN-gamma-indoleamine-2,3 dioxygenase acts as a major suppressive factor in 4-1BB-mediated immune suppression in vivo. J Leukoc Biol. 2009 May; 85(5):817-25. Kim YH, Choi BK, Kang WJ, Kim KH, Kang SW, Mellor AL, Munn DH, Kwon BS. PMID: 19218483; PMCID: PMC2669405.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    48. Indoleamine 2,3-dioxygenase is a critical regulator of acute graft-versus-host disease lethality. Blood. 2008 Mar 15; 111(6):3257-65. Jasperson LK, Bucher C, Panoskaltsis-Mortari A, Taylor PA, Mellor AL, Munn DH, Blazar BR. PMID: 18077788; PMCID: PMC2265461.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    49. Role of CD28 in fatal autoimmune disorder in scurfy mice. Blood. 2007 Aug 15; 110(4):1199-206. Singh N, Chandler PR, Seki Y, Baban B, Takezaki M, Kahler DJ, Munn DH, Larsen CP, Mellor AL, Iwashima M. PMID: 17463170; PMCID: PMC1939901.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    50. Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes. J Clin Invest. 2004 Jul; 114(2):280-90. Munn DH, Sharma MD, Hou D, Baban B, Lee JR, Antonia SJ, Messina JL, Chandler P, Koni PA, Mellor AL. PMID: 15254595; PMCID: PMC449750.
      View in: PubMed   Mentions: 346     Fields:    Translation:HumansAnimalsCells
    51. Cutting edge: induced indoleamine 2,3 dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansion. J Immunol. 2003 Aug 15; 171(4):1652-5. Mellor AL, Baban B, Chandler P, Marshall B, Jhaver K, Hansen A, Koni PA, Iwashima M, Munn DH. PMID: 12902462.
      View in: PubMed   Mentions: 155     Fields:    Translation:AnimalsCells
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