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    Josh Neman-Ebrahim, PhD

    TitleAssistant Professor of Neurological Surgery
    SchoolKeck School of Medicine of USC
    DepartmentNeurological Surgery
    AddressHMR 2011 Zonal Ave Bldg HMR
    University Park Campus
    Los Angeles California 90089
    Phone+1 323 442 2928
    Emailyebrahim@usc.edu
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      Dr. Neman is an Assistant Professor of Neurosurgery and member of the Norris Comprehensive Cancer Center at the Keck School of Medicine of USC. Dr. Neman received his doctoral degree at the UCLA David Geffen School of Medicine in neurobiology. He then went on to complete his cancer biology fellowship at the City of Hope’s Beckman Research Institute where he was a California Institute for Regenerative Medicine (CIRM) Fellow. Dr. Neman’s research at USC investigates the biology of breast to brain metastases and medulloblastoma (the most aggressive pediatric brain tumor).

      His expertise and strengths in stem cell biology and neuroscience have allowed him to develop novel molecular, cellular, and systems approach to study the interaction between the brain and cancer cells (termed the tumor microenvironment)–a bidirectional interplay poorly understood. As a neuroscientist, Dr. Neman’s goal is to raise awareness that transdisciplinary research between neurobiology and cancer foundations can advance our current understanding of how the nervous system contributes to primary and metastatic brain tumors. This will ultimately result in development of improved strategies for cancer prevention and treatment of patients with these devastating diseases.


      Collapse Biography 
      Collapse Awards and Honors
      UCLAGonda/Goldschmeid Neuroscience Award
      City of Hope and Beckman Research InstituteOutstanding Postdoctoral Research Project Award

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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Jandial R, Neman J, Lim PP, Tamae D, Kowolik CM, Wuenschell GE, Shuck SC, Ciminera AK, De Jesus LR, Ouyang C, Chen MY, Termini J. Inhibition of GLO1 in Glioblastoma Multiforme Increases DNA-AGEs, Stimulates RAGE Expression, and Inhibits Brain Tumor Growth in Orthotopic Mouse Models. Int J Mol Sci. 2018 Jan 30; 19(2). PMID: 29385725.
        View in: PubMed
      2. Priceman SJ, Tilakawardane D, Jeang B, Aguilar B, Murad JP, Park AK, Chang WC, Ostberg JR, Neman J, Jandial R, Portnow J, Forman SJ, Brown CE. Regional Delivery of Chimeric Antigen Receptor-Engineered T Cells Effectively Targets HER2+Breast Cancer Metastasis to the Brain. Clin Cancer Res. 2018 Jan 01; 24(1):95-105. PMID: 29061641.
        View in: PubMed
      3. Choy C, Ansari KI, Neman J, Hsu S, Duenas MJ, Li H, Vaidehi N, Jandial R. Cooperation of neurotrophin receptor TrkB and Her2 in breast cancer cells facilitates brain metastases. Breast Cancer Res. 2017 Apr 26; 19(1):51. PMID: 28446206.
        View in: PubMed
      4. Bankaitis K, Borriello L, Cox T, Lynch C, Zijlstra A, Fingleton B, Gužvić M, Anderson R, Neman J. Meeting report: Metastasis Research Society-Chinese Tumor Metastasis Society joint conference on metastasis. Clin Exp Metastasis. 2017 Apr; 34(3-4):203-213. PMID: 28260197.
        View in: PubMed
      5. Martirosian V, Chen TC, Lin M, Neman J. Medulloblastoma initiation and spread: Where neurodevelopment, microenvironment and cancer cross pathways. J Neurosci Res. 2016 Dec; 94(12):1511-1519. PMID: 27629382.
        View in: PubMed
      6. Choy C, Raytis JL, Smith DD, Duenas M, Neman J, Jandial R, Lew MW. Inhibition of β2-adrenergic receptor reduces triple-negative breast cancer brain metastases: The potential benefit of perioperative β-blockade. Oncol Rep. 2016 Jun; 35(6):3135-42. PMID: 27035124.
        View in: PubMed
      7. Termini J, Neman J, Jandial R. Role of the neural niche in brain metastatic cancer. Cancer Res. 2014 Aug 01; 74(15):4011-5. PMID: 25035392; PMCID: PMC4122250.
      8. Jandial R, Neman J, Chen MY. Therapeutic disruption of the blood brain barrier in metastasis. Neurosurgery. 2014 Apr; 74(4):N11-2. PMID: 24642987.
        View in: PubMed
      9. Neman J, Termini J, Wilczynski S, Vaidehi N, Choy C, Kowolik CM, Li H, Hambrecht AC, Roberts E, Jandial R. Human breast cancer metastases to the brain display GABAergic properties in the neural niche. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):984-9. PMID: 24395782; PMCID: PMC3903266.
      10. Li G, Warden C, Zou Z, Neman J, Krueger JS, Jain A, Jandial R, Chen M. Altered expression of polycomb group genes in glioblastoma multiforme. PLoS One. 2013; 8(11):e80970. PMID: 24260522; PMCID: PMC3829908.
      11. Neman J, Choy C, Kowolik CM, Anderson A, Duenas VJ, Waliany S, Chen BT, Chen MY, Jandial R. Co-evolution of breast-to-brain metastasis and neural progenitor cells. Clin Exp Metastasis. 2013 Aug; 30(6):753-68. PMID: 23456474; PMCID: PMC3808473.
      12. Neman J, Duenas V, Kowolik C, Hambrecht A, Chen M, Jandial R. Lineage mapping and characterization of the native progenitor population in cellular allograft. Spine J. 2013 Feb; 13(2):162-174. PMID: 23305812; PMCID: PMC3893135.
      13. Neman J, de Vellis J. A method for deriving homogenous population of oligodendrocytes from mouse embryonic stem cells. Dev Neurobiol. 2012 Jun; 72(6):777-88. PMID: 22234971.
        View in: PubMed
      14. Jandial R, Neman J, Termini J. Genetic mutations and tissue type lead to heterogeneous metabolic profiles in tumors. Neurosurgery. 2012 Jun; 70(6):N20-1. PMID: 22596009.
        View in: PubMed
      15. Zou Z, Denny E, Brown CE, Jensen MC, Li G, Fujii T, Neman J, Jandial R, Chen M. Cytotoxic T lymphocyte trafficking and survival in an augmented fibrin matrix carrier. PLoS One. 2012; 7(4):e34652. PMID: 22496835; PMCID: PMC3319597.
      16. Neman J, Hambrecht A, Cadry C, Jandial R. Stem cell-mediated osteogenesis: therapeutic potential for bone tissue engineering. Biologics. 2012; 6:47-57. PMID: 22500114; PMCID: PMC3324839.
      17. Neman J, Hambrecht A, Cadry C, Goodarzi A, Youssefzadeh J, Chen MY, Jandial R. Clinical efficacy of stem cell mediated osteogenesis and bioceramics for bone tissue engineering. Adv Exp Med Biol. 2012; 760:174-87. PMID: 23281520.
        View in: PubMed
      18. Hambrecht A, Jandial R, Neman J. Emerging role of brain metastases in the prognosis of breast cancer patients. Breast Cancer (Dove Med Press). 2011 Aug 10; 3:79-91. PMID: 24367178; PMCID: PMC3846823.
      19. Neman J, Somlo G, Jandial R. Classification of genomic changes in breast cancer brain metastasis. Neurosurgery. 2010 Aug; 67(2):N18-9. PMID: 20644404.
        View in: PubMed
      20. Neman J, Jandial R. Decreasing glioma recurrence through adjuvant cancer stem cell inhibition. Biologics. 2010 Jun 24; 4:157-62. PMID: 20631819; PMCID: PMC2898103.
      21. Neman J, Jandial R. Translational emphasis: hypoxia and vasculogenesis in glioma recurrence. Neurosurgery. 2010 Jun; 66(6):N20-1. PMID: 20495415.
        View in: PubMed
      22. Kateb B, Chiu K, Black KL, Yamamoto V, Khalsa B, Ljubimova JY, Ding H, Patil R, Portilla-Arias JA, Modo M, Moore DF, Farahani K, Okun MS, Prakash N, Neman J, Ahdoot D, Grundfest W, Nikzad S, Heiss JD. Nanoplatforms for constructing new approaches to cancer treatment, imaging, and drug delivery: what should be the policy? Neuroimage. 2011 Jan; 54 Suppl 1:S106-24. PMID: 20149882; PMCID: PMC3524337.
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