Hui Li, MD

Title(s)Assistant Professor of Research Medicine
SchoolKeck School of Medicine of Usc
AddressMMR 626 1333 San Pablo Street
Off Campus
Los Angeles CA 90033
Phone+1 323 442 1039
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    Dr. Li's main research interests are in epithelial ion transport physiology and the coupling of membrane transport processes to cellular metabolism via the metabolic sensor AMP-activated protein kinase (AMPK). His current research involves mechanisms and relevance of sodium transport regulation by AMPK, and the role of modulating AMPK and other signaling mediators in autosomal dominant polycystic kidney disease and acute kidney injury.

    Dr. Li earned his medical degree from Shenyang Medical College. Prior to joining USC, Dr. Li served as a Research Assistant Professor in the Renal-Electrolyte Division at The University of Pittsburgh.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. β1Pix exchange factor stabilizes the ubiquitin ligase Nedd4-2 and plays a critical role in ENaC regulation by AMPK in kidney epithelial cells. J Biol Chem. 2018 07 20; 293(29):11612-11624. Ho PY, Li H, Pavlov TS, Tuerk RD, Tabares D, Brunisholz R, Neumann D, Staruschenko A, Hallows KR. PMID: 29858246; PMCID: PMC6065188.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    2. Using Ex Vivo Kidney Slices to Study AMPK Effects on Kidney Proteins. Methods Mol Biol. 2018; 1732:449-464. Rao R, Omi K, Rajani R, Li H, Pastor-Soler NM. PMID: 29480492.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Lack of Effects of Metformin and AICAR Chronic Infusion on the Development of Hypertension in Dahl Salt-Sensitive Rats. Front Physiol. 2017; 8:227. Pavlov TS, Levchenko V, Ilatovskaya DV, Li H, Palygin O, Pastor-Soler NM, Hallows KR, Staruschenko A. PMID: 28473772; PMCID: PMC5397526.
      View in: PubMed   Mentions: 13  
    4. Renoprotective Effects of Metformin are Independent of Organic Cation Transporters 1 &2 and AMP-activated Protein Kinase in the Kidney. Sci Rep. 2016 10 26; 6:35952. Christensen M, Jensen JB, Jakobsen S, Jessen N, Frøkiær J, Kemp BE, Marciszyn AL, Li H, Pastor-Soler NM, Hallows KR, Nørregaard R. PMID: 27782167; PMCID: PMC5080611.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    5. Activation of the metabolic sensor AMP-activated protein kinase inhibits aquaporin-2 function in kidney principal cells. Am J Physiol Renal Physiol. 2016 11 01; 311(5):F890-F900. Al-Bataineh MM, Li H, Ohmi K, Gong F, Marciszyn AL, Naveed S, Zhu X, Neumann D, Wu Q, Cheng L, Fenton RA, Pastor-Soler NM, Hallows KR. PMID: 27534994; PMCID: PMC5130465.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    6. Aurora kinase A activates the vacuolar H+-ATPase (V-ATPase) in kidney carcinoma cells. Am J Physiol Renal Physiol. 2016 06 01; 310(11):F1216-28. Al-Bataineh MM, Alzamora R, Ohmi K, Ho PY, Marciszyn AL, Gong F, Li H, Hallows KR, Pastor-Soler NM. PMID: 26911844; PMCID: PMC4935778.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    7. Epithelial morphological reversion drives Profilin-1-induced elevation of p27(kip1) in mesenchymal triple-negative human breast cancer cells through AMP-activated protein kinase activation. Cell Cycle. 2015; 14(18):2914-23. Jiang C, Veon W, Li H, Hallows KR, Roy P. PMID: 26176334; PMCID: PMC4825560.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    8. Interactions between HIF-1α and AMPK in the regulation of cellular hypoxia adaptation in chronic kidney disease. Am J Physiol Renal Physiol. 2015 Sep 01; 309(5):F414-28. Li H, Satriano J, Thomas JL, Miyamoto S, Sharma K, Pastor-Soler NM, Hallows KR, Singh P. PMID: 26136559; PMCID: PMC4556888.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    9. Akt recruits Dab2 to albumin endocytosis in the proximal tubule. Am J Physiol Renal Physiol. 2014 Dec 15; 307(12):F1380-9. Koral K, Li H, Ganesh N, Birnbaum MJ, Hallows KR, Erkan E. PMID: 25253241; PMCID: PMC4269696.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    10. A1 adenosine receptor-stimulated exocytosis in bladder umbrella cells requires phosphorylation of ADAM17 Ser-811 and EGF receptor transactivation. Mol Biol Cell. 2014 Nov 15; 25(23):3798-812. Prakasam HS, Gallo LI, Li H, Ruiz WG, Hallows KR, Apodaca G. PMID: 25232008; PMCID: PMC4230785.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    11. Resveratrol inhibits the epithelial sodium channel via phopshoinositides and AMP-activated protein kinase in kidney collecting duct cells. PLoS One. 2013; 8(10):e78019. Weixel KM, Marciszyn A, Alzamora R, Li H, Fischer O, Edinger RS, Hallows KR, Johnson JP. PMID: 24205069; PMCID: PMC3812018.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    12. AMP-activated protein kinase regulates the vacuolar H+-ATPase via direct phosphorylation of the A subunit (ATP6V1A) in the kidney. Am J Physiol Renal Physiol. 2013 Oct 01; 305(7):F943-56. Alzamora R, Al-Bataineh MM, Liu W, Gong F, Li H, Thali RF, Joho-Auchli Y, Brunisholz RA, Satlin LM, Neumann D, Hallows KR, Pastor-Soler NM. PMID: 23863464; PMCID: PMC3798744.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    13. AMPK couples plasma renin to cellular metabolism by phosphorylation of ACC1. Am J Physiol Renal Physiol. 2013; 305(5):F679-90. Fraser SA, Choy SW, Pastor-Soler NM, Li H, Cook N, Katerelos M, Mount, PF, Gleich K, McRae JL, Dwyer KM, van Denderen BJW, Hallows KR, Kemp BE, and Power DA.
    14. Nedd4-2 Regulation by 14-3-3 Binding at Canonical SGK1 Phosphorylation Sites. J Biol Chem. 2011; 286:37830-40. Chandran S, Li H, Dong W, Krasinska K, Adams C, Alexandrova L, Chien A, Hallows KR, Bhalla V.
    15. Galectin-7 modulates the length of the primary cilia and wound repair in polarized kidney epithelial cells. Am J Physiol Renal Physiol. 2011; 301:F622-33. Rondanino C, Poland PA, Kinlough CL, Li H, Rbaibi Y, Myerburg MM, Al-Bataineh MM, Kashlan OB, Pastor-Soler NM, Hallows KR, Weisz OA, Apodaca G, Hughey RP.
    16. Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis. Proc Natl Acad Sci U S A. 2011; 108:2462-7. Takiar V, Nishio S, Seo-Mayer P, King JD Jr, Li H, Zhang L, Karihaloo A, Hallows KR, Somlo S, Caplan MJ.
    17. PKA regulates vacuolar H+-ATPase localization and activity via direct phosphorylation of the A subunit in kidney cells. J Biol Chem. 2010; 285:24676-85. Alzamora R, Thali RF, Gong F, Smolak C, Li H, Baty CJ, Bertrand CA, Auchli Y, Brunisholz RA, Neumann D, Hallows KR, Pastor-Soler NM.
    18. Phosphopeptide screen uncovers novel Nedd4-2 phosphorylation sites that potentiate its inhibition of the epithelial Na+ channel. J Biol Chem. 2010; 285:21671-8.. Hallows KR, Bhalla V, Oyster NM, Wijngaarden MA, Lee JK, Li H, Chandran S, Xia X, Huang Z, Chalkley RJ, Burlingame AL, Pearce D.
    19. Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells. Am J Physiol Renal Physiol. 2010; 299(1):F167-77. Li H, Thali RF, Smolak C, Gong F, Alzamora R, Wallimann T, Scholz R, Pastor-Soler NM, Neumann D, Hallows KR.
    20. Vacuolar H+-ATPase apical accumulation in kidney intercalated cells is regulated by PKA and AMP-activated protein kinase. Am J Physiol Renal Physiol. 2010; 298(5):F1162-9. Gong F, Alzamora R, Smolak C, Li H, Naveed S, Neumann D, Hallows KR, Pastor-Soler NM.
    21. Specific and slow inhibition of the kir2.1 K+ channel by gambogic acid. J Biol Chem. 2009; 284:15432-8. . Zaks-Makhina E, Li H, Grishin A, Salvador-Recatala V, Levitan ES.
    22. AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells. Am J Physiol Cell Physiol. 2009; 296:C672-81. Hallows KR, Alzamora R, Li H, Gong F, Smolak C, Neumann D, Pastor-Soler NM.
    23. Regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cells. J Biol Chem. 2009; 284:5774-83. Hallows KR, Wang H, Edinger RS, Butterworth MB, Oyster NM, Li H, Buck J, Levin LR, Johnson JP, Pastor-Soler NM.
    24. Functional regulation of the epithelial Na+ channel by IkappaB kinase-beta occurs via phosphorylation of the ubiquitin ligase Nedd4-2. J Biol Chem. 2008; 284:150-7. Edinger RS, Lebowitz J, Li H, Alzamora R, Wang H, Johnson JP, Hallows KR.
    25. Identification of GRIF-1 (TRAK2) as a trafficking factor for the K+ channel Kir2.1. J Biol Chem. 2006; 281:30104-11.. Grishin A, Li H, Levitan ES, Zaks-Makhina E.
    26. Attenuation of apoptosis in enterocytes by blockade of potassium channels. Am J Physiol Gastrointest Liver Physiol. 2005; 289:G815-21. Grishin A, Ford H, Wang J, Li H, Salvador-Recatala V, Levitan ES, Zaks-Makhina E.
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    NIH Funding Acknowledgment: Important - All publications resulting from the utilization of SC CTSI resources are required to credit the SC CTSI grant by including the NIH funding acknowledgment and must comply with the NIH Public Access Policy.

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