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    Duke Han, PhD

    TitleAssociate Professor Family Medicine (Clinical Scholar)
    SchoolKeck School of Medicine of USC
    DepartmentFamily Medicine
    AddressHSA Unit22 A-7 7423 1000 S. Fremont Avenue
    Off Campus
    Alhambra California 91803
    Phone+1 626 457 5858
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      Collapse Overview 
      Collapse Overview
      Dr. Duke Han is a diplomate of the American Board of Professional Psychology in clinical neuropsychology, Director of Neuropsychology in the Department of Family Medicine, and an Associate Professor of Family Medicine, Neurology, Psychology, and Gerontology at the Keck School of Medicine of the University of Southern California. Dr. Han is interested in the factors that impact cognition and decision making in aging. He also has special interests in using novel neuroimaging and statistical approaches to better understand these factors. Dr. Han maintains an active research collaboration with the Rush Alzheimer's Disease Center of Rush University Medical Center in Chicago, where he was most recently a tenured faculty member. He is the recipient of the Paul B. Beeson Career Development Award in Aging Research, which is supported by the National Institute on Aging, the American Federation of Aging Research (AFAR), and the John A. Hartford Foundation. Dr. Han is actively involved in peer-review of research grants for the National Institute on Aging (NIA) and manuscripts for over 30 scientific journals. He is on the editorial board for the Journal of Alzheimer’s Disease and Archives of Clinical Neuropsychology, and is a member of the Governance Committee of the Global Council for Brain Health, an independent science collaborative convened by the AARP and AgeUK. At the Keck School of Medicine of USC, he was awarded the distinction of Clinical Scholar, which is an honor given by the President of the University. Dr. Han currently holds leadership or mentorship roles in the International Neuropsychological Society (INS), the National Academy of Neuropsychology (NAN), the American Academy of Clinical Neuropsychology (AACN), and the Society of Clinical Neuropsychology (Division 40) of the American Psychological Association.


      Collapse Biography 
      Collapse Education and Training
      Duke University, Durham, NCBS05/1998Psychology/Neuroscience
      University of Massachusetts Boston, Boston, MAPhD12/2004Clinical Psychology/Neuropsychology
      Collapse Awards and Honors
      International Neuropsychological Society2006Nelson Butters Award
      American Psychological Association2012Division 40 Blue Ribbon Award
      National Institutes of Aging/AFAR2012  - 2017Paul B. Beason Award for Aging Research
      AARP and AgeUK2015  - 2018Global Council on Brain Health Governance Member

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      Collapse Featured Publications
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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Duke Han S, Nguyen CP, Stricker NH, Nation DA. Detectable Neuropsychological Differences in Early Preclinical Alzheimer's Disease: A Meta-Analysis. Neuropsychol Rev. 2017 May 11. PMID: 28497179.
        View in: PubMed
      2. Duke Han S, Boyle PA, Yu L, Arfanakis K, James BD, Fleischman DA, Bennett DA. Grey matter correlates of susceptibility to scams in community-dwelling older adults. Brain Imaging Behav. 2016 Jun; 10(2):524-32. PMID: 26100658; PMCID: PMC4689662 [Available on 06/01/17].
      3. Han D, Boyle PA, Arfanakis K, Fleischman D, Yu L, James BD, Bennett DA. Financial literacy is associated with white matter integrity in old age. Neuroimage. 2016 Apr 15; 130:223-9. PMID: 26899784; PMCID: PMC4808430 [Available on 04/15/17].
      4. Han D, Boyle PA, James BD, Yu L, Bennett DA. Mild Cognitive Impairment and Susceptibility to Scams in Old Age. J Alzheimers Dis. 2016; 49(3):845-51. PMID: 26519434; PMCID: PMC4708889.
      5. Lachs MS, Han D. Age-Associated Financial Vulnerability: An Emerging Public Health Issue. Ann Intern Med. 2015 Dec 01; 163(11):877-8. PMID: 26458261; PMCID: PMC4769872.
      6. Han D, Boyle PA, James BD, Yu L, Barnes LL, Bennett DA. Discrepancies between cognition and decision making in older adults. Aging Clin Exp Res. 2016 Feb; 28(1):99-108. PMID: 25995167; PMCID: PMC4654982 [Available on 02/01/17].
      7. Nation DA, Edmonds EC, Bangen KJ, Delano-Wood L, Scanlon BK, Han D, Edland SD, Salmon DP, Galasko DR, Bondi MW. Pulse pressure in relation to tau-mediated neurodegeneration, cerebral amyloidosis, and progression to dementia in very old adults. JAMA Neurol. 2015 May; 72(5):546-53. PMID: 25822631; PMCID: PMC4428938.
      8. Han D, Boyle PA, James BD, Yu L, Bennett DA. Poorer Financial and Health Literacy Among Community-Dwelling Older Adults With Mild Cognitive Impairment. J Aging Health. 2015 Sep; 27(6):1105-17. PMID: 25903976; PMCID: PMC4520748.
      9. Han D, Boyle PA, James BD, Yu L, Bennett DA. Mild cognitive impairment is associated with poorer decision-making in community-based older persons. J Am Geriatr Soc. 2015 Apr; 63(4):676-83. PMID: 25850350; PMCID: PMC4406791.
      10. James BD, Boyle PA, Yu L, Han D, Bennett DA. Cognitive decline is associated with risk aversion and temporal discounting in older adults without dementia. PLoS One. 2015; 10(4):e0121900. PMID: 25838074; PMCID: PMC4383618.
      11. Han D, Boyle PA, Yu L, Fleischman DA, Arfanakis K, Leurgans S, Bennett DA. Financial literacy is associated with medial brain region functional connectivity in old age. Arch Gerontol Geriatr. 2014 Sep-Oct; 59(2):429-38. PMID: 24893911; PMCID: PMC4130771.
      12. Han D, Boyle PA, Yu L, Fleischman DA, Arfanakis K, Bennett DA. Ventromedial PFC, parahippocampal, and cerebellar connectivity are associated with temporal discounting in old age. Exp Gerontol. 2013 Dec; 48(12):1489-98. PMID: 24135750; PMCID: PMC3855854.
      13. Fleischman DA, Leurgans S, Arfanakis K, Arvanitakis Z, Barnes LL, Boyle PA, Han D, Bennett DA. Gray-matter macrostructure in cognitively healthy older persons: associations with age and cognition. Brain Struct Funct. 2014 Nov; 219(6):2029-49. PMID: 23955313; PMCID: PMC3926914.
      14. Fleischman DA, Yu L, Arfanakis K, Han D, Barnes LL, Arvanitakis Z, Boyle PA, Bennett DA. Faster cognitive decline in the years prior to MR imaging is associated with smaller hippocampal volumes in cognitively healthy older persons. Front Aging Neurosci. 2013; 5:21. PMID: 23760360; PMCID: PMC3672675.
      15. Wingo J, Kalkut E, Tuminello E, Asconape J, Han D. Executive functions, depressive symptoms, and college adjustment in women. Appl Neuropsychol Adult. 2013; 20(2):136-44. PMID: 23397999.
        View in: PubMed
      16. Han D, Gruhl J, Beckett L, Dodge HH, Stricker NH, Farias S, Mungas D. Beta amyloid, tau, neuroimaging, and cognition: sequence modeling of biomarkers for Alzheimer's Disease. Brain Imaging Behav. 2012 Dec; 6(4):610-20. PMID: 22648764; PMCID: PMC3582336.
      17. Stricker NH, Dodge HH, Dowling NM, Han D, Erosheva EA, Jagust WJ. CSF biomarker associations with change in hippocampal volume and precuneus thickness: implications for the Alzheimer's pathological cascade. Brain Imaging Behav. 2012 Dec; 6(4):599-609. PMID: 22614327; PMCID: PMC3656503.
      18. Duke Han S, Buchman AS, Arfanakis K, Fleischman DA, Bennett DA. Functional connectivity networks associated with chronic musculoskeletal pain in old age. Int J Geriatr Psychiatry. 2013 Aug; 28(8):858-67. PMID: 23124844; PMCID: PMC3594549.
      19. Ruppert P, Edmonds EC, Brook M, Musil S, Han D. Neuropsychological assessment in a case of adult-onset hemophagocytic lymphohistiocytosis (HLH). Clin Neuropsychol. 2012; 26(6):1038-52. PMID: 22784400.
        View in: PubMed
      20. Guidotti Breting LM, Tuminello ER, Duke Han S. Functional neuroimaging studies in normal aging. Curr Top Behav Neurosci. 2012; 10:91-111. PMID: 21751096.
        View in: PubMed
      21. Han D, Boyle PA, Arfanakis K, Fleischman DA, Yu L, Edmonds EC, Bennett DA. Neural intrinsic connectivity networks associated with risk aversion in old age. Behav Brain Res. 2012 Feb 01; 227(1):233-40. PMID: 22044475; PMCID: PMC3242855.
      22. Han D, Arfanakis K, Fleischman DA, Leurgans SE, Tuminello ER, Edmonds EC, Bennett DA. Functional connectivity variations in mild cognitive impairment: associations with cognitive function. J Int Neuropsychol Soc. 2012 Jan; 18(1):39-48. PMID: 22005016; PMCID: PMC3368801.
      23. Schiehser DM, Delis DC, Filoteo JV, Delano-Wood L, Han D, Jak AJ, Drake AI, Bondi MW. Are self-reported symptoms of executive dysfunction associated with objective executive function performance following mild to moderate traumatic brain injury? J Clin Exp Neuropsychol. 2011 Jul; 33(6):704-14. PMID: 21958432; PMCID: PMC3325052.
      24. Tuminello ER, Han D. The apolipoprotein e antagonistic pleiotropy hypothesis: review and recommendations. Int J Alzheimers Dis. 2011 Feb 24; 2011:726197. PMID: 21423560; PMCID: PMC3056453.
      25. Han D, Suzuki H, Jak AJ, Chang YL, Salmon DP, Bondi MW. Hierarchical cognitive and psychosocial predictors of amnestic mild cognitive impairment. J Int Neuropsychol Soc. 2010 Jul; 16(4):721-9. PMID: 20561399; PMCID: PMC3005198.
      26. Suzuki H, Han D, Lucas LR. Increased 5-HT1B receptor density in the basolateral amygdala of passive observer rats exposed to aggression. Brain Res Bull. 2010 Aug 30; 83(1-2):38-43. PMID: 20599596.
        View in: PubMed
      27. Bangen KJ, Jak AJ, Schiehser DM, Delano-Wood L, Tuminello E, Han D, Delis DC, Bondi MW. Complex activities of daily living vary by mild cognitive impairment subtype. J Int Neuropsychol Soc. 2010 Jul; 16(4):630-9. PMID: 20374675; PMCID: PMC2891154.
      28. Suzuki H, Han D, Lucas LR. Chronic passive exposure to aggression decreases D2 and 5-HT 1B receptor densities. Physiol Behav. 2010 Apr 19; 99(5):562-70. PMID: 20114057.
        View in: PubMed
      29. Schiehser DM, Han D, Lessig S, Song DD, Zizak V, Filoteo JV. Predictors of health status in nondepressed and nondemented individuals with Parkinson's disease. Arch Clin Neuropsychol. 2009 Nov; 24(7):699-709. PMID: 19767296; PMCID: PMC2770862.
      30. Han D, Wible CG. Neuroimaging of semantic processing in schizophrenia: a parametric priming approach. Int J Psychophysiol. 2010 Feb; 75(2):100-6. PMID: 19765623; PMCID: PMC2827622.
      31. Kalkut EL, Han D, Lansing AE, Holdnack JA, Delis DC. Development of set-shifting ability from late childhood through early adulthood. Arch Clin Neuropsychol. 2009 Sep; 24(6):565-74. PMID: 19679594.
        View in: PubMed
      32. Han D, Suzuki H, Drake AI, Jak AJ, Houston WS, Bondi MW. Clinical, cognitive, and genetic predictors of change in job status following traumatic brain injury in a military population. J Head Trauma Rehabil. 2009 Jan-Feb; 24(1):57-64. PMID: 19158597; PMCID: PMC3319716.
      33. Han D, Bangen KJ, Bondi MW. Functional magnetic resonance imaging of compensatory neural recruitment in aging and risk for Alzheimer's disease: review and recommendations. Dement Geriatr Cogn Disord. 2009; 27(1):1-10. PMID: 19088472; PMCID: PMC2820574.
      34. Han D, Bondi MW. Revision of the apolipoprotein E compensatory mechanism recruitment hypothesis. Alzheimers Dement. 2008 Jul; 4(4):251-4. PMID: 18631975.
        View in: PubMed
      35. Han D, Drake AI, Cessante LM, Jak AJ, Houston WS, Delis DC, Filoteo JV, Bondi MW. Apolipoprotein E and traumatic brain injury in a military population: evidence of a neuropsychological compensatory mechanism?. Journal of Neurology, Neurosurgery, and Psychiatry. 2007; 78(10):1103-1108.
      36. Han D, Drake AI, Cessante LM, Jak AJ, Houston WS, Delis DC, Filoteo JV, Bondi MW. Apolipoprotein E and traumatic brain injury in a military population: evidence of a neuropsychological compensatory mechanism? J Neurol Neurosurg Psychiatry. 2007 Oct; 78(10):1103-8. PMID: 17287237; PMCID: PMC2117544.
      37. Han D, Nestor PG, Hale-Spencer M, Cohen A, Niznikiewicz M, McCarley RW, Wible CG. Functional neuroimaging of word priming in males with chronic schizophrenia. Neuroimage. 2007 Mar; 35(1):273-82. PMID: 17215145; PMCID: PMC1852450.
      38. Delis, Dean C.; Lansing, Amy; Houston, Wes S.; Wetter, Spencer; Han, S. Duke; Jacobson, Mark; Holdnack, James; Kramer, Joel. Creativity Lost: The Importance of Testing Higher-Level Executive Functions in School-Age Children and Adolescents. Journal of Psychoeducational Assessment. 2007; 25:29-40.
      39. Han D, Houston WS, Jak AJ, Eyler LT, Nagel BJ, Fleisher AS, Brown GG, Corey-Bloom J, Salmon DP, Thal LJ, Bondi MW. Verbal paired-associate learning by APOE genotype in non-demented older adults: fMRI evidence of a right hemispheric compensatory response. Neurobiol Aging. 2007 Feb; 28(2):238-47. PMID: 16434125; PMCID: PMC1705815.
      40. Wible CG, Han D, Spencer MH, Kubicki M, Niznikiewicz MH, Jolesz FA, McCarley RW, Nestor P. Connectivity among semantic associates: an fMRI study of semantic priming. Brain Lang. 2006 Jun; 97(3):294-305. PMID: 16413049.
        View in: PubMed
      41. Han D, Nestor PG, Wible CG. fMRI of lexical-semantic priming in a chronic schizophrenia patient. Appl Neuropsychol. 2006; 13(1):51-7. PMID: 16594871.
        View in: PubMed
      42. Han D, Nestor PG, Shenton ME, Niznikiewicz M, Hannah G, McCarley RW. Associative memory in chronic schizophrenia: a computational model. Schizophr Res. 2003 Jun 01; 61(2-3):255-63. PMID: 12729877; PMCID: PMC2849103.
      43. Nestor PG, Han D, Niznikiewicz M, Salisbury D, Spencer K, Shenton ME, McCarley RW. Semantic disturbance in schizophrenia and its relationship to the cognitive neuroscience of attention. Biol Psychol. 2001 Jul-Aug; 57(1-3):23-46. PMID: 11454433; PMCID: PMC2849104.