Richard Castriotta, MD

Title(s)Professor of Clinical Medicine
SchoolKeck School of Medicine of Usc
Address2020 Zonal Ave.
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 9454
ORCID ORCID Icon0000-0003-3502-4558 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Boston College High School, Boston, MA6/1963Science
    Holy Cross College, Worcester, MAA.B.06/1967pre-medical
    University of Bologna, Bologna, ItalyM.D.03/1974Medicine
    Yale University / St. Raphael Hosp, New Haven, CT6/1978Internal Medicine
    University of Connecticut, Farmington, CT6/1980Pulmonary Disease
    University of Connecticut, Farmington, CT12/1980Immunology
    University of Freiburg, Freiburg, Germany8/1964German
    University of Houston, Clear Lake, TX6/2001Busines Administration
    Collapse Awards and Honors
    Marquis Who's Who2018Albert Nelson Marquis Lifetime Achievement Award
    American College of Chest Physicians2017Distinguished CHEST Educator
    Castle Connolly2016  - 2023Top Doctors - Pulmonary Disease
    Houstonia Magazine2014  - 2019Houston's Top Doctors

    Collapse Overview 
    Collapse Overview
    Richard J. Castriotta, M.D., FCCP, FAASM is a Professor of Clinical Medicine at the University of Southern California Keck School of Medicine in Los Angeles and Professor Emeritus at the University of Texas Health Science Center at Houston McGovern Medical School (UTHealth). He has served as Professor of Internal Medicine, and Director of the Division of Pulmonary, Critical Care and Sleep Medicine at UTHealth as well as Chief of Pulmonary Medicine, Chairman of the Institutional Ethics Committee and Medical Director of the Sleep Disorders Center and Pulmonary Diagnostic Services at Memorial Hermann Hospital - Texas Medical Center in Houston. He has served as President of the Southern Sleep Society, Chair of the Connecticut Thoracic Society Section on Sleep Medicine, Chair of the American College of Chest Physicians (ACCP) Sleep NetWork Steering Committee, Chair of the ACCP Palliative and End-of-Life Care NetWork, a member of the ACCP SEEK Editorial Board and Vice Chair of the Southern Medical Association Chest Disease Section. He is now President of the Southern Sleep Foundation Board of Directors. He is a Distinguished Educator and Fellow of the American College of Chest Physicians and a fellow of the American Academy of Sleep Medicine. His research interests involve REM sleep behavior disorder and Parkinson’s disease, sleep-related hypoventilation, complex sleep apnea and adaptive servo-ventilation, control of breathing in obesity, sleep architecture in agenesis of the corpus callosum and sleep-disordered breathing in heart and lung transplant patients, ventricular assist devices, and atrial fibrillation.

    Dr. Castriotta is currently Director of the Keck/USC Sleep Disorders Center. He is an internationally-recognized leader in pulmonary, critical care and sleep medicine as a clinician, teacher and researcher. He has been a pioneer in the field of sleep medicine, establishing a sleep laboratory in 1981 and a formal sleep medicine fellowship program in 1999. He was the senior author on the papers establishing the safety and efficacy in using helium to treat acute severe asthma with consequent reduction in asthma mortality. He was instrumental in establishing the definitive diagnosis of sarcoidosis by imaging studies. He was the first author on the definitive study of sleep disorders after traumatic brain injury and he remains one of the world’s experts in this field.

    Collapse Research 
    Collapse Research Activities and Funding
    Electrophysiologi Biomarkers of Atrial Fibrillation inPatients with Obstructive Sleep Apnea
    SC CTSI Pilot Funding SC CTSIJul 1, 2019 - Jun 30, 2020
    Role: Co-Investigator
    National Registry of patients with interstitial lung disease
    Pulmonary Fibrosis Foundation IRB 16-079012303Jan 1, 2016 - Jan 31, 2019
    Role: Site director for Houston

    Collapse ORNG Applications 
    Collapse Featured Publications

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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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      Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
      1. Recommended timing of medications that impact sleep and wakefulness: A review of the American Prescribers' Digital Reference. Sleep Med Rev. 2023 02; 67:101714. Khoshnevis S, Smolensky MH, Haghayegh S, Castriotta RJ, Hermida RC, Diller KR. PMID: 36509029.
        View in: PubMed   Mentions:    Fields:    Translation:Humans
      2. Novel temperature-controlled sleep system to improve sleep: a proof-of-concept study. J Sleep Res. 2022 Dec; 31(6):e13662. Haghayegh S, Khoshnevis S, Smolensky MH, Hermida RC, Castriotta RJ, Schernhammer E, Diller KR. PMID: 35852479.
        View in: PubMed   Mentions: 3     Fields:    Translation:Humans
      3. Circadian rhythms of risk factors and management in atherosclerotic and hypertensive vascular disease: Modern chronobiological perspectives of an ancient disease. Chronobiol Int. 2023 01; 40(1):33-62. Geng YJ, Smolensky MH, Sum-Ping O, Hermida R, Castriotta RJ. PMID: 35758140; PMCID: PMC10355310.
        View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
      4. Duration of positive airway pressure adherence: how much PAP is enough? J Clin Sleep Med. 2022 04 01; 18(4):969-970. Paz Y Mar H, Castriotta RJ. PMID: 35105437; PMCID: PMC8974384.
        View in: PubMed   Mentions:    Fields:    Translation:Humans
      5. The Circadian Rhythm of Thermoregulation Modulates both the Sleep/Wake Cycle and 24 h Pattern of Arterial Blood Pressure. Compr Physiol. 2021 10 12; 11(4):2645-2658. Haghayegh S, Smolensky MH, Khoshnevis S, Hermida RC, Castriotta RJ, Diller KR. PMID: 34636410.
        View in: PubMed   Mentions: 5     Fields:    Translation:Humans
      6. Deep Neural Network Sleep Scoring Using Combined Motion and Heart Rate Variability Data. Sensors (Basel). 2020 Dec 23; 21(1). Haghayegh S, Khoshnevis S, Smolensky MH, Diller KR, Castriotta RJ. PMID: 33374527; PMCID: PMC7793092.
        View in: PubMed   Mentions: 4     Fields:    Translation:Humans
      7. Guidelines for the design and conduct of human clinical trials on ingestion-time differences - chronopharmacology and chronotherapy - of hypertension medications. Chronobiol Int. 2021 01; 38(1):1-26. Hermida RC, Smolensky MH, Balan H, Castriotta RJ, Crespo JJ, Dagan Y, El-Toukhy S, Fernández JR, FitzGerald GA, Fujimura A, Geng YJ, Hermida-Ayala RG, Machado AP, Menna-Barreto L, Mojón A, Otero A, Rudic RD, Schernhammer E, Skarke C, Steen TY, Young ME, Zhao X. PMID: 33342316; PMCID: PMC8112296.
        View in: PubMed   Mentions: 2     Fields:    Translation:Humans
      8. A Study of the Relationship Between Uric Acid and Substantia Nigra Brain Connectivity in Patients With REM Sleep Behavior Disorder and Parkinson's Disease. Front Neurol. 2020; 11:815. Ellmore TM, Suescun J, Castriotta RJ, Schiess MC. PMID: 32849245; PMCID: PMC7419698.
        View in: PubMed   Mentions: 9  
      9. Resolution of sexsomnia with paroxetine. J Clin Sleep Med. 2020 07 15; 16(7):1213-1214. Kumar V, Grbach VX, Castriotta RJ. PMID: 32672534; PMCID: PMC7954066.
        View in: PubMed   Mentions:    Fields:    Translation:Humans
      10. Pathophysiological characteristics and therapeutic approaches for pulmonary injury and cardiovascular complications of coronavirus disease 2019. Cardiovasc Pathol. 2020 Jul - Aug; 47:107228. Geng YJ, Wei ZY, Qian HY, Huang J, Lodato R, Castriotta RJ. PMID: 32375085; PMCID: PMC7162778.
        View in: PubMed   Mentions: 60     Fields:    Translation:HumansCellsPHPublic Health
      11. Accuracy of Wristband Fitbit Models in Assessing Sleep: Systematic Review and Meta-Analysis. J Med Internet Res. 2019 11 28; 21(11):e16273. Haghayegh S, Khoshnevis S, Smolensky MH, Diller KR, Castriotta RJ. PMID: 31778122; PMCID: PMC6908975.
        View in: PubMed   Mentions: 104     Fields:    Translation:Humans
      12. Performance assessment of new-generation Fitbit technology in deriving sleep parameters and stages. Chronobiol Int. 2020 01; 37(1):47-59. Haghayegh S, Khoshnevis S, Smolensky MH, Diller KR, Castriotta RJ. PMID: 31718308.
        View in: PubMed   Mentions: 19     Fields:    Translation:Humans
      13. Performance comparison of different interpretative algorithms utilized to derive sleep parameters from wrist actigraphy data. Chronobiol Int. 2019 12; 36(12):1752-1760. Haghayegh S, Khoshnevis S, Smolensky MH, Diller KR, Castriotta RJ. PMID: 31658822.
        View in: PubMed   Mentions: 14     Fields:    Translation:Humans
      14. Cutting for Cures: Bariatric Surgery and Obstructive Sleep Apnea. J Clin Sleep Med. 2019 10 15; 15(10):1391-1392. Castriotta RJ, Chung P. PMID: 31596201; PMCID: PMC6778347.
        View in: PubMed   Mentions: 1     Fields:    Translation:Humans
      15. Before-bedtime passive body heating by warm shower or bath to improve sleep: A systematic review and meta-analysis. Sleep Med Rev. 2019 08; 46:124-135. Haghayegh S, Khoshnevis S, Smolensky MH, Diller KR, Castriotta RJ. PMID: 31102877.
        View in: PubMed   Mentions: 21     Fields:    Translation:Humans
      16. Irwin and Rippe's Intensive Care Medicine (edited by Richard S. Irwin, Craig M Lilly, Paul H. Mayo and James M. Rippe). Managing Non-Pain Symptoms in Critically Ill Patients. 2018; 318-329. Castriotta RJ, Reidy JE, McKelvy BJ, Barreda-Garcia J, Mak G.
      17. Sense and Sensitivity: Obstructive Sleep Apnea, Morning Blood Pressure, and Occult Hypertension. J Clin Sleep Med. 2017 07 15; 13(7):861-862. Castriotta RJ. PMID: 28633716; PMCID: PMC5482576.
        View in: PubMed   Mentions: 1     Fields:    Translation:Humans
      18. Sleep-disordered breathing in heart failure patients after ventricular assist device implantation and heart transplantation. Panminerva Med. 2017 Sep; 59(3):221-229. Chowdhury A, Mathew R, Castriotta RJ. PMID: 28488842.
        View in: PubMed   Mentions:    Fields:    Translation:Humans
      19. Ventricular assist devices and sleep-disordered breathing. Sleep Med Rev. 2017 10; 35:51-61. Akkanti B, Castriotta RJ, Sayana P, Nunez E, Rajapreyar I, Kumar S, Nathan S, Majid R. PMID: 27641662.
        View in: PubMed   Mentions: 2     Fields:    Translation:Humans
      20. Screening for sleep apnea in the perioperative setting: looking for the right compromise. Minerva Anestesiol. 2016 08; 82(8):914-5. Sparkle T, Sridhar S, Corso RM, Castriotta R, Courtney S, Mullaly A, Hagberg CA, Cattano D. PMID: 26744266.
        View in: PubMed   Mentions:    Fields:    Translation:Humans
      21. Assessing risk of obstructive sleep apnea by STOP-BANG questionnaire in an adult surgical population screened in the preoperative anesthesia clinic. Minerva Anestesiol. 2016 05; 82(5):605-6. Cattano D, Sridhar S, Cai C, Mullaly A, Kainer L, Sparkle T, Castriotta RJ, Courtney S, Hagberg CA. PMID: 26449776.
        View in: PubMed   Mentions: 3     Fields:    Translation:Humans
      22. Return to Lonesome Dove: when the patient wants to go home without surgery. Am J Bioeth. 2015; 15(1):68. Castriotta RJ. PMID: 25562240.
        View in: PubMed   Mentions:    Fields:    Translation:Humans
      23. Sleep Medicine: Comprehensive Guide to Its Development, Clinical Milestones and Advances in Treatment. Ed by S. Chokroverty and M. Billiard. Springer. Sleep Disorders after Traumatic Brain Injury: Milestones in Perspective. 2015. Castriotta RJ, Wilde MC.
      24. Averaging of diffusion tensor imaging direction-encoded color maps for localizing substantia nigra. Comput Biol Med. 2014 Aug; 51:104-10. Ellmore TM, Murphy SM, Cruz K, Castriotta RJ, Schiess MC. PMID: 24905890.
        View in: PubMed   Mentions: 1     Fields:    Translation:Humans
      25. High hypopnea/apnea ratio (HAR) in extreme obesity. J Clin Sleep Med. 2014 Apr 15; 10(4):391-6. Mathew R, Castriotta RJ. PMID: 24733984; PMCID: PMC3960381.
        View in: PubMed   Mentions: 14     Fields:    Translation:Humans
      26. Complex Sleep Apnea. Sleep Medicine Clinics. 2013; 8(4):463-475. Castriotta RJ, Majid R. View Publication.
      27. Altered nigrostriatal and nigrocortical functional connectivity in rapid eye movement sleep behavior disorder. Sleep. 2013 Dec 01; 36(12):1885-92. Ellmore TM, Castriotta RJ, Hendley KL, Aalbers BM, Furr-Stimming E, Hood AJ, Suescun J, Beurlot MR, Hendley RT, Schiess MC. PMID: 24293763; PMCID: PMC3825438.
        View in: PubMed   Mentions: 47     Fields:    Translation:Humans
      28. (Mis) perceptions and interactions of sleep specialists and generalists: obstacles to referrals to sleep specialists and the multidisciplinary team management of sleep disorders. J Clin Sleep Med. 2012 Dec 15; 8(6):633-42. Hayes SM, Murray S, Castriotta RJ, Landrigan CP, Malhotra A. PMID: 23243396; PMCID: PMC3501659.
        View in: PubMed   Mentions: 15     Fields:    Translation:Humans
      29. Sleep Disorders in Spinal Cord Injury. Sleep Medicine Clinics. 2012; 7(4):643-653. Castriotta RJ, Wilde MC, Sahay S. View Publication.
      30. Sleep disorders in patients with traumatic brain injury: a review. CNS Drugs. 2011 Mar; 25(3):175-85. Castriotta RJ, Murthy JN. PMID: 21062105.
        View in: PubMed   Mentions: 37     Fields:    Translation:Humans
      31. Reduced volume of the putamen in REM sleep behavior disorder patients. Parkinsonism Relat Disord. 2010 Dec; 16(10):645-9. Ellmore TM, Hood AJ, Castriotta RJ, Stimming EF, Bick RJ, Schiess MC. PMID: 20846895.
        View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
      32. Workshop on idiopathic pulmonary fibrosis in older adults. Chest. 2010 Sep; 138(3):693-703. Castriotta RJ, Eldadah BA, Foster WM, Halter JB, Hazzard WR, Kiley JP, King TE, Horne FM, Nayfield SG, Reynolds HY, Schmader KE, Toews GB, High KP. PMID: 20822991; PMCID: PMC4694103.
        View in: PubMed   Mentions: 19     Fields:    Translation:Humans
      33. Thermal infrared imaging: a novel method to monitor airflow during polysomnography. Sleep. 2009 Nov; 32(11):1521-7. Murthy JN, van Jaarsveld J, Fei J, Pavlidis I, Harrykissoon RI, Lucke JF, Faiz S, Castriotta RJ. PMID: 19928392; PMCID: PMC2768959.
        View in: PubMed   Mentions: 20     Fields:    Translation:Humans
      34. The utility of delayed-enhancement magnetic resonance imaging for identifying nonischemic myocardial fibrosis in asymptomatic patients with biopsy-proven systemic sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 2009 Jul; 26(1):39-46. Cheong BY, Muthupillai R, Nemeth M, Lambert B, Dees D, Huber S, Castriotta R, Flamm SD. PMID: 19960787.
        View in: PubMed   Mentions: 22     Fields:    Translation:Humans
      35. Hypoventilation after spinal cord injury. Semin Respir Crit Care Med. 2009 Jun; 30(3):330-8. Castriotta RJ, Murthy JN. PMID: 19452393.
        View in: PubMed   Mentions: 5     Fields:    Translation:Humans
      36. Treatment of sleep disorders after traumatic brain injury. J Clin Sleep Med. 2009 Apr 15; 5(2):137-44. Castriotta RJ, Atanasov S, Wilde MC, Masel BE, Lai JM, Kuna ST. PMID: 19968047; PMCID: PMC2670333.
        View in: PubMed   Mentions: 19     Fields:    Translation:HumansCTClinical Trials
      37. Withdrawal of life sustaining treatment in children in the first year of life. J Perinatol. 2008 Sep; 28(9):641-5. Eason EB, Castriotta RJ, Gremillion V, Sparks JW. PMID: 18596715.
        View in: PubMed   Mentions: 1     Fields:    Translation:Humans
      38. Body position and obstructive sleep apnea in 8-12-month-old infants. Int J Pediatr Otorhinolaryngol. 2008 Jun; 72(6):897-900. Pereira KD, Rathi NK, Fatakia A, Haque SA, Castriotta RJ. PMID: 18423893.
        View in: PubMed   Mentions: 7     Fields:    Translation:Humans
      39. Cognitive impairment in patients with traumatic brain injury and obstructive sleep apnea. Arch Phys Med Rehabil. 2007 Oct; 88(10):1284-8. Wilde MC, Castriotta RJ, Lai JM, Atanasov S, Masel BE, Kuna ST. PMID: 17908570.
        View in: PubMed   Mentions: 33     Fields:    Translation:Humans
      40. Prevalence and consequences of sleep disorders in traumatic brain injury. J Clin Sleep Med. 2007 Jun 15; 3(4):349-56. Castriotta RJ, Wilde MC, Lai JM, Atanasov S, Masel BE, Kuna ST. PMID: 17694722; PMCID: PMC1978308.
        View in: PubMed   Mentions: 90     Fields:    Translation:Humans
      41. Role of sleep-wake cycle on blood pressure circadian rhythms and hypertension. Sleep Med. 2007 Sep; 8(6):668-80. Smolensky MH, Hermida RC, Castriotta RJ, Portaluppi F. PMID: 17383936.
        View in: PubMed   Mentions: 59     Fields:    Translation:Humans
      42. Sleep disorders associated with traumatic brain injury. Arch Phys Med Rehabil. 2001 Oct; 82(10):1403-6. Castriotta RJ, Lai JM. PMID: 11588744.
        View in: PubMed   Mentions: 21     Fields:    Translation:Humans
      43. The effect of polysomnography on sleep position: possible implications on the diagnosis of positional obstructive sleep apnea. Respiration. 1996; 63(5):283-7. Metersky ML, Castriotta RJ. PMID: 8885000.
        View in: PubMed   Mentions: 29     Fields:    Translation:Humans
      44. Heliox therapy in acute severe asthma. Chest. 1995 Mar; 107(3):757-60. Kass JE, Castriotta RJ. PMID: 7874949.
        View in: PubMed   Mentions: 18     Fields:    Translation:Humans
      45. Obstructive sleep apnea due to a carotid body paraganglioma. Sleep. 1995 Jan; 18(1):53-4. Metersky ML, Castriotta RJ, Elnaggar A. PMID: 7761743.
        View in: PubMed   Mentions: 4     Fields:    Translation:Humans
      46. Alpha-delta sleep in patients with a chief complaint of chronic fatigue. South Med J. 1994 Apr; 87(4):465-70. Manu P, Lane TJ, Matthews DA, Castriotta RJ, Watson RK, Abeles M. PMID: 8153772.
        View in: PubMed   Mentions: 16     Fields:    Translation:Humans
      47. The effect of circuit weight training on cardiovascular function in healthy sedentary males. Journal of Cardiopulmonary Rehabilitation. 1994; 14:378-383. Kass JE, Castriotta RJ.
      48. A critical technico-ethical dilemma of current medicine. HEC Forum. 1993 Mar; 5(2):77-82. Castriotta RJ. PMID: 10145798.
        View in: PubMed   Mentions:    Fields:    Translation:Humans
      49. Intensive care unit outcome in the very elderly. Crit Care Med. 1992 Dec; 20(12):1666-71. Kass JE, Castriotta RJ, Malakoff F. PMID: 1458943.
        View in: PubMed   Mentions: 22     Fields:    Translation:Humans
      50. Panda sign--avid and symmetrical radiogallium accumulation in the lacrimal and parotid glands. Semin Nucl Med. 1991 Oct; 21(4):339-40. Sulavik SB, Spencer RP, Castriotta RJ. PMID: 1754897.
        View in: PubMed   Mentions: 1     Fields:    Translation:Humans
      51. Recognition of distinctive patterns of gallium-67 distribution in sarcoidosis. J Nucl Med. 1990 Dec; 31(12):1909-14. Sulavik SB, Spencer RP, Weed DA, Shapiro HR, Shiue ST, Castriotta RJ. PMID: 2266386.
        View in: PubMed   Mentions: 16     Fields:    Translation:Humans
      52. Adjustment of DLCO for varying COHb, and alveolar PO2 using a theoretical adjustment equation. Respir Physiol. 1990 Sep; 81(3):303-11. Frey TM, Crapo RO, Jensen RL, Kanner RE, Kass JE, Castriotta RJ, Mohsenifar Z. PMID: 2259790.
        View in: PubMed   Mentions: 1     Fields:    Translation:Humans
      53. Helium-oxygen mixtures in intubated patients with status asthmaticus and respiratory acidosis. Chest. 1990 Sep; 98(3):693-8. Gluck EH, Onorato DJ, Castriotta R. PMID: 2118449.
        View in: PubMed   Mentions: 20     Fields:    Translation:Humans
      54. Effect of inhaled triamcinolone on bronchial hyperreactivity and airways obstruction in asthma. Ann Allergy. 1990 Feb; 64(2 Pt 2):207-12. Zu Wallack RL, Kass J, Shiue ST, Godar TJ, Lahiri B, Schatz PL, Castriotta RJ, Glenn BR. PMID: 2301782.
        View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
      55. Treatment of acute serum sickness by plasma ultrafiltration. Am J Med Sci. 1987 Feb; 293(2):75-84. Kilpatrick JM, Pitt A, Allen S, Ainsworth SK, Castriotta RJ, Virella G. PMID: 3565456.
        View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
      56. Strain variation of bacillus Calmette-Guerin-induced pulmonary granuloma formation is correlated with anergy and the local production of migration inhibition factor and interleukin 1. Am J Pathol. 1985 May; 119(2):223-35. Kobayashi K, Allred C, Castriotta R, Yoshida T. PMID: 3887931; PMCID: PMC1887892.
        View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
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