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Michael E. Harris

TitleProfessor of The Practice of Health Services Administration and Policy
InstitutionUniversity of Southern California
DepartmentPublic Policy
AddressRGL 315
University Park Campus
Los Angeles CA 90089-0626
Phone+1 213 821 0467
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    Collapse Overview 
    Collapse Overview
    Mr. Harris joined the University of Southern California as an adjunct faculty member and is now a Professor of the Practice of Health Services Administration and Policy at the Sol Price School of Public Policy at USC.

    Mr. Harris’s focus center on health care issues related to prevention, wellness, and access to care for all populations. He is well versed in the areas of health care reform and the Affordable Care Act. With over 30 years of experience, he is focused on the development of future healthcare delivery models, healthcare innovation and its impact on quality of care concepts.

    Mr. Harris is also a nationally recognized speaker with over 30 years of healthcare experience in the areas of managed care payer and provider contracting, Independent Physician Associations, Management Service Organizations, medical group operations, and management of ancillary services. As one of the nation’s leading authorities on healthcare reform, he advises numerous healthcare organizations on the impact of reform and delivery system adaptability.

    Prior to becoming a leading healthcare consultant, Mr. Harris served in several executive positions responsible for the operational efficiency and performance of healthcare delivery systems.

    His civic involvement includes:

    Commissioner of Sustainability
    City of Palm Springs
    Clinton Health Initiative
    City of Palm Springs
    Regional Access Project Foundation
    Healthy Eating Active Living Network (HEALNet)
    City of Palm Springs


    Collapse Research 
    Collapse Research Activities and Funding
    Specificity in Substrate Recognition and Catalysis by RNA Processing Enzymes
    NIH/NIGMS R35GM127100Jul 5, 2018 - Jun 30, 2023
    Role: Principal Investigator
    Mechanistic Enzymology of Phosphoryl Transfer Enzymes
    NIH/NIGMS R01GM096000Sep 15, 2011 - Feb 28, 2018
    Role: Principal Investigator
    Determination of enzyme isotope effects by tandem ESI-Q/TOF mass spectrometry
    NIH/NIGMS R21GM079647Feb 1, 2007 - Jan 31, 2010
    Role: Principal Investigator
    STOPPED-FLOW CD AND FLUORESCENCE SPECTROMETER
    NIH/NCRR S10RR014923Mar 1, 2000 - Feb 28, 2001
    Role: Principal Investigator
    Structure and function of RNase P
    NIH/NIGMS R01GM056740Jan 1, 1998 - Dec 31, 2015
    Role: Principal Investigator
    Bridges to Success in the Sciences
    NIH/NIGMS R25GM049010Sep 1, 1993 - Aug 31, 2019
    Role: Co-Principal Investigator
    EUKARYOTIC RIBONUCLEASE P RNA
    NIH/NIGMS F32GM015979Aug 1, 1993
    Role: Principal Investigator
    Graduate Training in Cell and Molecular Biology
    NIH/NIGMS T32GM008056Sep 22, 1983 - Jun 30, 2020
    Role: Co-Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Zhao J, Harris ME. Distributive enzyme binding controlled by local RNA context results in 3' to 5' directional processing of dicistronic tRNA precursors by Escherichia coli ribonuclease P. Nucleic Acids Res. 2018 Nov 28. PMID: 30496557.
      View in: PubMed
    2. Lu J, Koo SC, Weissman BP, Harris ME, Li NS, Piccirilli JA. Evidence That Nucleophile Deprotonation Exceeds Bond Formation in the HDV Ribozyme Transition State. Biochemistry. 2018 May 17. PMID: 29733591.
      View in: PubMed
    3. Huff SE, Mohammed FA, Yang M, Agrawal P, Pink J, Harris ME, Dealwis CG, Viswanathan R. Structure-Guided Synthesis and Mechanistic Studies Reveal Sweetspots on Naphthyl Salicyl Hydrazone Scaffold as Non-Nucleosidic Competitive, Reversible Inhibitors of Human Ribonucleotide Reductase. J Med Chem. 2018 Feb 08; 61(3):666-680. PMID: 29253340.
      View in: PubMed
    4. Harris ME, York DM, Piccirilli JA, Anderson VE. Kinetic Isotope Effect Analysis of RNA 2'-O-Transphosphorylation. Methods Enzymol. 2017; 596:433-457. PMID: 28911780.
      View in: PubMed
    5. Knappenberger AJ, Grandhi S, Sheth R, Ahmad MF, Viswanathan R, Harris ME. Phylogenetic sequence analysis and functional studies reveal compensatory amino acid substitutions in loop 2 of human ribonucleotide reductase. J Biol Chem. 2017 10 06; 292(40):16463-16476. PMID: 28808063.
      View in: PubMed
    6. Ahmad MF, Alam I, Huff SE, Pink J, Flanagan SA, Shewach D, Misko TA, Oleinick NL, Harte WE, Viswanathan R, Harris ME, Dealwis CG. Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule. Proc Natl Acad Sci U S A. 2017 Aug 01; 114(31):8241-8246. PMID: 28716944.
      View in: PubMed
    7. Niland CN, Anderson DR, Jankowsky E, Harris ME. The contribution of the C5 protein subunit of Escherichia coli ribonuclease P to specificity for precursor tRNA is modulated by proximal 5' leader sequences. RNA. 2017 10; 23(10):1502-1511. PMID: 28694328.
      View in: PubMed
    8. Jankowsky E, Harris ME. Mapping specificity landscapes of RNA-protein interactions by high throughput sequencing. Methods. 2017 Apr 15; 118-119:111-118. PMID: 28263887.
      View in: PubMed
    9. Jain N, Lin HC, Morgan CE, Harris ME, Tolbert BS. Rules of RNA specificity of hnRNP A1 revealed by global and quantitative analysis of its affinity distribution. Proc Natl Acad Sci U S A. 2017 02 28; 114(9):2206-2211. PMID: 28193894.
      View in: PubMed
    10. Harris ME, Anderson VE. Preface. Methods Enzymol. 2017; 596:xv-xviii. PMID: 28911786.
      View in: PubMed
    11. Vijayaraghavan J, Kramp K, Harris ME, van den Akker F. Inhibition of soluble guanylyl cyclase by small molecules targeting the catalytic domain. FEBS Lett. 2016 Oct; 590(20):3669-3680. PMID: 27654641.
      View in: PubMed
    12. Knappenberger AJ, Ahmad MF, Viswanathan R, Dealwis CG, Harris ME. Nucleoside Analogue Triphosphates Allosterically Regulate Human Ribonucleotide Reductase and Identify Chemical Determinants That Drive Substrate Specificity. Biochemistry. 2016 Oct 18; 55(41):5884-5896. PMID: 27634056.
      View in: PubMed
    13. Lin HC, Zhao J, Niland CN, Tran B, Jankowsky E, Harris ME. Analysis of the RNA Binding Specificity Landscape of C5 Protein Reveals Structure and Sequence Preferences that Direct RNase P Specificity. Cell Chem Biol. 2016 Oct 20; 23(10):1271-1281. PMID: 27693057.
      View in: PubMed
    14. Niland CN, Zhao J, Lin HC, Anderson DR, Jankowsky E, Harris ME. Determination of the Specificity Landscape for Ribonuclease P Processing of Precursor tRNA 5' Leader Sequences. ACS Chem Biol. 2016 08 19; 11(8):2285-92. PMID: 27336323.
      View in: PubMed
    15. Niland CN, Jankowsky E, Harris ME. Optimization of high-throughput sequencing kinetics for determining enzymatic rate constants of thousands of RNA substrates. Anal Biochem. 2016 10 01; 510:1-10. PMID: 27296633; PMCID: PMC4980219 [Available on 10/01/17].
      View in: PubMed, PubMed Central
    16. Misko TA, Wijerathna SR, Radivoyevitch T, Berdis AJ, Ahmad MF, Harris ME, Dealwis CG. Inhibition of yeast ribonucleotide reductase by Sml1 depends on the allosteric state of the enzyme. FEBS Lett. 2016 06; 590(12):1704-12. PMID: 27155231; PMCID: PMC4925217 [Available on 06/01/17].
      View in: PubMed, PubMed Central
    17. Mullins MR, Rajavel M, Hernandez-Sanchez W, de la Fuente M, Biendarra SM, Harris ME, Taylor DJ. POT1-TPP1 Binding and Unfolding of Telomere DNA Discriminates against Structural Polymorphism. J Mol Biol. 2016 07 03; 428(13):2695-708. PMID: 27173378; PMCID: PMC4905795 [Available on 07/03/17].
      View in: PubMed, PubMed Central
    18. Zhang S, Gu H, Chen H, Strong E, Ollie EW, Kellerman D, Liang D, Miyagi M, Anderson VE, Piccirilli JA, York DM, Harris ME. Isotope effect analyses provide evidence for an altered transition state for RNA 2'-O-transphosphorylation catalyzed by Zn(2+). Chem Commun (Camb). 2016 Mar 25; 52(24):4462-5. PMID: 26859380; PMCID: PMC4916458.
      View in: PubMed, PubMed Central
    19. Lee TS, Radak BK, Harris ME, York DM. A Two-Metal-Ion-Mediated Conformational Switching Pathway for HDV Ribozyme Activation. ACS Catal. 2016; 6(3):1853-1869. PMID: 27774349.
      View in: PubMed
    20. Ahmad MF, Huff SE, Pink J, Alam I, Zhang A, Perry K, Harris ME, Misko T, Porwal SK, Oleinick NL, Miyagi M, Viswanathan R, Dealwis CG. Identification of Non-nucleoside Human Ribonucleotide Reductase Modulators. J Med Chem. 2015 Dec 24; 58(24):9498-509. PMID: 26488902; PMCID: PMC4751996.
      View in: PubMed, PubMed Central
    21. Harris ME. Theme and Variation in tRNA 5' End Processing Enzymes: Comparative Analysis of Protein versus Ribonucleoprotein RNase P. J Mol Biol. 2016 Jan 16; 428(1):5-9. PMID: 26655024.
      View in: PubMed
    22. Jankowsky E, Harris ME. Specificity and nonspecificity in RNA-protein interactions. Nat Rev Mol Cell Biol. 2015 Sep; 16(9):533-44. PMID: 26285679; PMCID: PMC4744649.
      View in: PubMed, PubMed Central
    23. Koo SC, Lu J, Li NS, Leung E, Das SR, Harris ME, Piccirilli JA. Transition State Features in the Hepatitis Delta Virus Ribozyme Reaction Revealed by Atomic Perturbations. J Am Chem Soc. 2015 Jul 22; 137(28):8973-82. PMID: 26125657; PMCID: PMC4758122.
      View in: PubMed, PubMed Central
    24. Radak BK, Lee TS, Harris ME, York DM. Assessment of metal-assisted nucleophile activation in the hepatitis delta virus ribozyme from molecular simulation and 3D-RISM. RNA. 2015 Sep; 21(9):1566-77. PMID: 26170378; PMCID: PMC4536318.
      View in: PubMed, PubMed Central
    25. Mojica MF, Mahler SG, Bethel CR, Taracila MA, Kosmopoulou M, Papp-Wallace KM, Llarrull LI, Wilson BM, Marshall SH, Wallace CJ, Villegas MV, Harris ME, Vila AJ, Spencer J, Bonomo RA. Exploring the Role of Residue 228 in Substrate and Inhibitor Recognition by VIM Metallo-ß-lactamases. Biochemistry. 2015 May 26; 54(20):3183-96. PMID: 25915520; PMCID: PMC4700511.
      View in: PubMed, PubMed Central
    26. Kellerman DL, Simmons KS, Pedraza M, Piccirilli JA, York DM, Harris ME. Determination of hepatitis delta virus ribozyme N(-1) nucleobase and functional group specificity using internal competition kinetics. Anal Biochem. 2015 Aug 15; 483:12-20. PMID: 25937290; PMCID: PMC4461535.
      View in: PubMed, PubMed Central
    27. Harris ME, Piccirilli JA, York DM. Integration of kinetic isotope effect analyses to elucidate ribonuclease mechanism. Biochim Biophys Acta. 2015 Nov; 1854(11):1801-8. PMID: 25936517; PMCID: PMC4604014 [Available on 11/01/16].
      View in: PubMed, PubMed Central
    28. Chen H, Piccirilli JA, Harris ME, York DM. Effect of Zn2+ binding and enzyme active site on the transition state for RNA 2'-O-transphosphorylation interpreted through kinetic isotope effects. Biochim Biophys Acta. 2015 Nov; 1854(11):1795-800. PMID: 25812974; PMCID: PMC4743498.
      View in: PubMed, PubMed Central
    29. Dissanayake T, Swails JM, Harris ME, Roitberg AE, York DM. Interpretation of pH-activity profiles for acid-base catalysis from molecular simulations. Biochemistry. 2015 Feb 17; 54(6):1307-13. PMID: 25615525; PMCID: PMC4441796.
      View in: PubMed, PubMed Central
    30. Porwal SK, Furia E, Harris ME, Viswanathan R, Devireddy L. Synthetic, potentiometric and spectroscopic studies of chelation between Fe(III) and 2,5-DHBA supports salicylate-mode of siderophore binding interactions. J Inorg Biochem. 2015 Apr; 145:1-10. PMID: 25589161.
      View in: PubMed
    31. Chen H, Giese TJ, Huang M, Wong KY, Harris ME, York DM. Mechanistic insights into RNA transphosphorylation from kinetic isotope effects and linear free energy relationships of model reactions. Chemistry. 2014 Oct 27; 20(44):14336-43. PMID: 25223953; PMCID: PMC4432475.
      View in: PubMed, PubMed Central
    32. Lin HC, Yandek LE, Gjermeni I, Harris ME. Determination of relative rate constants for in vitro RNA processing reactions by internal competition. Anal Biochem. 2014 Dec 15; 467:54-61. PMID: 25173512; PMCID: PMC4252809.
      View in: PubMed, PubMed Central
    33. Kellerman DL, York DM, Piccirilli JA, Harris ME. Altered (transition) states: mechanisms of solution and enzyme catalyzed RNA 2'-O-transphosphorylation. Curr Opin Chem Biol. 2014 Aug; 21:96-102. PMID: 25023967; PMCID: PMC4149925.
      View in: PubMed, PubMed Central
    34. Merrick WC, Harris ME. Control not at initiation? Bah, humbug! EMBO J. 2014 Jan 07; 33(1):3-4. PMID: 24363142; PMCID: PMC3990677.
      View in: PubMed, PubMed Central
    35. Guenther UP, Yandek LE, Niland CN, Campbell FE, Anderson D, Anderson VE, Harris ME, Jankowsky E. Hidden specificity in an apparently nonspecific RNA-binding protein. Nature. 2013 Oct 17; 502(7471):385-8. PMID: 24056935; PMCID: PMC3800043.
      View in: PubMed, PubMed Central
    36. Gu H, Zhang S, Wong KY, Radak BK, Dissanayake T, Kellerman DL, Dai Q, Miyagi M, Anderson VE, York DM, Piccirilli JA, Harris ME. Experimental and computational analysis of the transition state for ribonuclease A-catalyzed RNA 2'-O-transphosphorylation. Proc Natl Acad Sci U S A. 2013 Aug 06; 110(32):13002-7. PMID: 23878223; PMCID: PMC3740856.
      View in: PubMed, PubMed Central
    37. Corriveau M, Mullins MR, Baus D, Harris ME, Taylor DJ. Coordinated interactions of multiple POT1-TPP1 proteins with telomere DNA. J Biol Chem. 2013 Jun 07; 288(23):16361-70. PMID: 23616058; PMCID: PMC3675573.
      View in: PubMed, PubMed Central
    38. Yandek LE, Lin HC, Harris ME. Alternative substrate kinetics of Escherichia coli ribonuclease P: determination of relative rate constants by internal competition. J Biol Chem. 2013 Mar 22; 288(12):8342-54. PMID: 23362254; PMCID: PMC3605652.
      View in: PubMed, PubMed Central
    39. Radak BK, Harris ME, York DM. Molecular simulations of RNA 2'-O-transesterification reaction models in solution. J Phys Chem B. 2013 Jan 10; 117(1):94-103. PMID: 23214417; PMCID: PMC3574632.
      View in: PubMed, PubMed Central
    40. Papp-Wallace KM, Senkfor B, Gatta J, Chai W, Taracila MA, Shanmugasundaram V, Han S, Zaniewski RP, Lacey BM, Tomaras AP, Skalweit MJ, Harris ME, Rice LB, Buynak JD, Bonomo RA. Early insights into the interactions of different ß-lactam antibiotics and ß-lactamase inhibitors against soluble forms of Acinetobacter baumannii PBP1a and Acinetobacter sp. PBP3. Antimicrob Agents Chemother. 2012 Nov; 56(11):5687-92. PMID: 22908165; PMCID: PMC3486531.
      View in: PubMed, PubMed Central
    41. Levitt PS, Papp-Wallace KM, Taracila MA, Hujer AM, Winkler ML, Smith KM, Xu Y, Harris ME, Bonomo RA. Exploring the role of a conserved class A residue in the O-Loop of KPC-2 ß-lactamase: a mechanism for ceftazidime hydrolysis. J Biol Chem. 2012 Sep 14; 287(38):31783-93. PMID: 22843686; PMCID: PMC3442512.
      View in: PubMed, PubMed Central
    42. Wong KY, Gu H, Zhang S, Piccirilli JA, Harris ME, York DM. Characterization of the reaction path and transition states for RNA transphosphorylation models from theory and experiment. Angew Chem Int Ed Engl. 2012 Jan 16; 51(3):647-51. PMID: 22076983; PMCID: PMC3448066.
      View in: PubMed, PubMed Central
    43. Lee TS, Giambasu G, Harris ME, York DM. Characterization of the Structure and Dynamics of the HDV Ribozyme at Different Stages Along the Reaction Path. J Phys Chem Lett. 2011 Oct 20; 2(20):2538-2543. PMID: 22200005.
      View in: PubMed
    44. Christian EL, Anderson VE, Harris ME. Deconvolution of Raman spectroscopic signals for electrostatic, H-bonding, and inner-sphere interactions between ions and dimethyl phosphate in solution. J Inorg Biochem. 2011 Apr; 105(4):538-47. PMID: 21334281; PMCID: PMC3268073.
      View in: PubMed, PubMed Central
    45. Harris ME, Dai Q, Gu H, Kellerman DL, Piccirilli JA, Anderson VE. Kinetic isotope effects for RNA cleavage by 2'-O- transphosphorylation: nucleophilic activation by specific base. J Am Chem Soc. 2010 Aug 25; 132(33):11613-21. PMID: 20669950; PMCID: PMC2946848.
      View in: PubMed, PubMed Central
    46. Christian EL, Anderson VE, Carey PR, Harris ME. A quantitative Raman spectroscopic signal for metal-phosphodiester interactions in solution. Biochemistry. 2010 Apr 06; 49(13):2869-79. PMID: 20180599; PMCID: PMC3246276.
      View in: PubMed, PubMed Central
    47. Koutmou KS, Zahler NH, Kurz JC, Campbell FE, Harris ME, Fierke CA. Protein-precursor tRNA contact leads to sequence-specific recognition of 5' leaders by bacterial ribonuclease P. J Mol Biol. 2010 Feb 12; 396(1):195-208. PMID: 19932118; PMCID: PMC2829246.
      View in: PubMed, PubMed Central
    48. Sun L, Campbell FE, Yandek LE, Harris ME. Binding of C5 protein to P RNA enhances the rate constant for catalysis for P RNA processing of pre-tRNAs lacking a consensus (+ 1)/C(+ 72) pair. J Mol Biol. 2010 Feb 05; 395(5):1019-37. PMID: 19917291; PMCID: PMC3410724.
      View in: PubMed, PubMed Central
    49. Harris ME, Christian EL. RNA crosslinking methods. Methods Enzymol. 2009; 468:127-46. PMID: 20946768; PMCID: PMC3246272.
      View in: PubMed, PubMed Central
    50. Harris ME, Cassano AG. Experimental analyses of the chemical dynamics of ribozyme catalysis. Curr Opin Chem Biol. 2008 Dec; 12(6):626-39. PMID: 18952193; PMCID: PMC2770263.
      View in: PubMed, PubMed Central
    51. Schroeder LA, Gries TJ, Saecker RM, Record MT, Harris ME, DeHaseth PL. Evidence for a tyrosine-adenine stacking interaction and for a short-lived open intermediate subsequent to initial binding of Escherichia coli RNA polymerase to promoter DNA. J Mol Biol. 2009 Jan 16; 385(2):339-49. PMID: 18976666; PMCID: PMC2677906.
      View in: PubMed, PubMed Central
    52. Dai Q, Frederiksen JK, Anderson VE, Harris ME, Piccirilli JA. Efficient synthesis of [2'-18O]uridine and its incorporation into oligonucleotides: a new tool for mechanistic study of nucleotidyl transfer reactions by isotope effect analysis. J Org Chem. 2008 Jan 04; 73(1):309-11. PMID: 18052189.
      View in: PubMed
    53. Sun L, Harris ME. Evidence that binding of C5 protein to P RNA enhances ribozyme catalysis by influencing active site metal ion affinity. RNA. 2007 Sep; 13(9):1505-15. PMID: 17652407; PMCID: PMC1950769.
      View in: PubMed, PubMed Central
    54. Cassano AG, Wang B, Anderson DR, Previs S, Harris ME, Anderson VE. Inaccuracies in selected ion monitoring determination of isotope ratios obviated by profile acquisition: nucleotide 18O/16O measurements. Anal Biochem. 2007 Aug 01; 367(1):28-39. PMID: 17560863; PMCID: PMC2045637.
      View in: PubMed, PubMed Central
    55. Sun L, Campbell FE, Zahler NH, Harris ME. Evidence that substrate-specific effects of C5 protein lead to uniformity in binding and catalysis by RNase P. EMBO J. 2006 Sep 06; 25(17):3998-4007. PMID: 16932744; PMCID: PMC1560353.
      View in: PubMed, PubMed Central
    56. Anderson VE, Ruszczycky MW, Harris ME. Activation of oxygen nucleophiles in enzyme catalysis. Chem Rev. 2006 Aug; 106(8):3236-51. PMID: 16895326.
      View in: PubMed
    57. Christian EL, Smith KM, Perera N, Harris ME. The P4 metal binding site in RNase P RNA affects active site metal affinity through substrate positioning. RNA. 2006 Aug; 12(8):1463-7. PMID: 16822954; PMCID: PMC1524898.
      View in: PubMed, PubMed Central
    58. Guo X, Campbell FE, Sun L, Christian EL, Anderson VE, Harris ME. RNA-dependent folding and stabilization of C5 protein during assembly of the E. coli RNase P holoenzyme. J Mol Biol. 2006 Jun 30; 360(1):190-203. PMID: 16750220.
      View in: PubMed
    59. Zahler NH, Sun L, Christian EL, Harris ME. The pre-tRNA nucleotide base and 2'-hydroxyl at N(-1) contribute to fidelity in tRNA processing by RNase P. J Mol Biol. 2005 Feb 04; 345(5):969-85. PMID: 15644198.
      View in: PubMed
    60. Cassano AG, Anderson VE, Harris ME. Analysis of solvent nucleophile isotope effects: evidence for concerted mechanisms and nucleophilic activation by metal coordination in nonenzymatic and ribozyme-catalyzed phosphodiester hydrolysis. Biochemistry. 2004 Aug 17; 43(32):10547-59. PMID: 15301552.
      View in: PubMed
    61. Cassano AG, Anderson VE, Harris ME. Understanding the transition states of phosphodiester bond cleavage: insights from heavy atom isotope effects. Biopolymers. 2004 Jan; 73(1):110-29. PMID: 14691944.
      View in: PubMed
    62. Harris ME, Christian EL. Recent insights into the structure and function of the ribonucleoprotein enzyme ribonuclease P. Curr Opin Struct Biol. 2003 Jun; 13(3):325-33. PMID: 12831883.
      View in: PubMed
    63. Zahler NH, Christian EL, Harris ME. Recognition of the 5' leader of pre-tRNA substrates by the active site of ribonuclease P. RNA. 2003 Jun; 9(6):734-45. PMID: 12756331; PMCID: PMC1370440.
      View in: PubMed, PubMed Central
    64. Kaye NM, Zahler NH, Christian EL, Harris ME. Conservation of helical structure contributes to functional metal ion interactions in the catalytic domain of ribonuclease P RNA. J Mol Biol. 2002 Nov 29; 324(3):429-42. PMID: 12445779.
      View in: PubMed
    65. Christian EL, Zahler NH, Kaye NM, Harris ME. Analysis of substrate recognition by the ribonucleoprotein endonuclease RNase P. Methods. 2002 Nov; 28(3):307-22. PMID: 12431435.
      View in: PubMed
    66. Cassano AG, Anderson VE, Harris ME. Evidence for direct attack by hydroxide in phosphodiester hydrolysis. J Am Chem Soc. 2002 Sep 18; 124(37):10964-5. PMID: 12224928.
      View in: PubMed
    67. Christian EL, Kaye NM, Harris ME. Evidence for a polynuclear metal ion binding site in the catalytic domain of ribonuclease P RNA. EMBO J. 2002 May 01; 21(9):2253-62. PMID: 11980722; PMCID: PMC125996.
      View in: PubMed, PubMed Central
    68. Kaye NM, Christian EL, Harris ME. NAIM and site-specific functional group modification analysis of RNase P RNA: magnesium dependent structure within the conserved P1-P4 multihelix junction contributes to catalysis. Biochemistry. 2002 Apr 09; 41(14):4533-45. PMID: 11926814.
      View in: PubMed
    69. Campbell FE, Cassano AG, Anderson VE, Harris ME. Pre-steady-state and stopped-flow fluorescence analysis of Escherichia coli ribonuclease III: insights into mechanism and conformational changes associated with binding and catalysis. J Mol Biol. 2002 Mar 15; 317(1):21-40. PMID: 11916377.
      View in: PubMed
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