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Michael E. Harris

Title(s)Professor of the Practice of Health Services Administration and Policy
Phone+1 213 821 0467
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    Collapse Overview 
    Collapse Overview
    Mr. Harris joined the University of Southern California as an adjunct faculty member and is now a Professor of the Practice of Health Services Administration and Policy at the Sol Price School of Public Policy at USC.

    Mr. Harris’s focus center on health care issues related to prevention, wellness, and access to care for all populations. He is well versed in the areas of health care reform and the Affordable Care Act. With over 30 years of experience, he is focused on the development of future healthcare delivery models, healthcare innovation and its impact on quality of care concepts.

    Mr. Harris is also a nationally recognized speaker with over 30 years of healthcare experience in the areas of managed care payer and provider contracting, Independent Physician Associations, Management Service Organizations, medical group operations, and management of ancillary services. As one of the nation’s leading authorities on healthcare reform, he advises numerous healthcare organizations on the impact of reform and delivery system adaptability.

    Prior to becoming a leading healthcare consultant, Mr. Harris served in several executive positions responsible for the operational efficiency and performance of healthcare delivery systems.

    His civic involvement includes:

    Commissioner of Sustainability
    City of Palm Springs
    Clinton Health Initiative
    City of Palm Springs
    Regional Access Project Foundation
    Healthy Eating Active Living Network (HEALNet)
    City of Palm Springs

    Collapse Research 
    Collapse Research Activities and Funding
    Specificity in Substrate Recognition and Catalysis by RNA Processing Enzymes
    NIH/NIGMS R35GM127100Jul 5, 2018 - Jun 30, 2023
    Role: Principal Investigator
    Mechanistic Enzymology of Phosphoryl Transfer Enzymes
    NIH/NIGMS R01GM096000Sep 15, 2011 - Feb 28, 2018
    Role: Principal Investigator
    Determination of enzyme isotope effects by tandem ESI-Q/TOF mass spectrometry
    NIH/NIGMS R21GM079647Feb 1, 2007 - Jan 31, 2010
    Role: Principal Investigator
    STOPPED-FLOW CD AND FLUORESCENCE SPECTROMETER
    NIH/NCRR S10RR014923Mar 1, 2000 - Feb 28, 2001
    Role: Principal Investigator
    Structure and function of RNase P
    NIH/NIGMS R01GM056740Jan 1, 1998 - Dec 31, 2015
    Role: Principal Investigator
    Bridges to Success in the Sciences
    NIH/NIGMS R25GM049010Sep 1, 1993 - Aug 31, 2019
    Role: Co-Principal Investigator
    EUKARYOTIC RIBONUCLEASE P RNA
    NIH/NIGMS F32GM015979Aug 1, 1993
    Role: Principal Investigator
    Graduate Training in Cell and Molecular Biology
    NIH/NIGMS T32GM008056Sep 22, 1983 - Jun 30, 2020
    Role: Co-Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Misko TA, Liu YT, Harris ME, Oleinick NL, Pink J, Lee HY, Dealwis CG. Structure-guided design of anti-cancer ribonucleotide reductase inhibitors. J Enzyme Inhib Med Chem. 2019 Dec; 34(1):438-450. PMID: 30734609.
      View in: PubMed
    2. Bevilacqua PC, Harris ME, Piccirilli JA, Gaines C, Ganguly A, Kostenbader K, Ekesan S, York DM. An Ontology for Facilitating Discussion of Catalytic Strategies of RNA-Cleaving Enzymes. ACS Chem Biol. 2019 Jun 21; 14(6):1068-1076. PMID: 31095369.
      View in: PubMed
    3. Zhao J, Harris ME. Distributive enzyme binding controlled by local RNA context results in 3' to 5' directional processing of dicistronic tRNA precursors by Escherichia coli ribonuclease P. Nucleic Acids Res. 2018 Nov 28. PMID: 30496557.
      View in: PubMed
    4. Lu J, Koo SC, Weissman BP, Harris ME, Li NS, Piccirilli JA. Evidence That Nucleophile Deprotonation Exceeds Bond Formation in the HDV Ribozyme Transition State. Biochemistry. 2018 06 26; 57(25):3465-3472. PMID: 29733591.
      View in: PubMed
    5. Huff SE, Mohammed FA, Yang M, Agrawal P, Pink J, Harris ME, Dealwis CG, Viswanathan R. Structure-Guided Synthesis and Mechanistic Studies Reveal Sweetspots on Naphthyl Salicyl Hydrazone Scaffold as Non-Nucleosidic Competitive, Reversible Inhibitors of Human Ribonucleotide Reductase. J Med Chem. 2018 02 08; 61(3):666-680. PMID: 29253340.
      View in: PubMed
    6. Harris ME, York DM, Piccirilli JA, Anderson VE. Kinetic Isotope Effect Analysis of RNA 2'-O-Transphosphorylation. Methods Enzymol. 2017; 596:433-457. PMID: 28911780.
      View in: PubMed
    7. Knappenberger AJ, Grandhi S, Sheth R, Ahmad MF, Viswanathan R, Harris ME. Phylogenetic sequence analysis and functional studies reveal compensatory amino acid substitutions in loop 2 of human ribonucleotide reductase. J Biol Chem. 2017 10 06; 292(40):16463-16476. PMID: 28808063.
      View in: PubMed
    8. Ahmad MF, Alam I, Huff SE, Pink J, Flanagan SA, Shewach D, Misko TA, Oleinick NL, Harte WE, Viswanathan R, Harris ME, Dealwis CG. Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule. Proc Natl Acad Sci U S A. 2017 08 01; 114(31):8241-8246. PMID: 28716944.
      View in: PubMed
    9. Niland CN, Anderson DR, Jankowsky E, Harris ME. The contribution of the C5 protein subunit of Escherichia coli ribonuclease P to specificity for precursor tRNA is modulated by proximal 5' leader sequences. RNA. 2017 10; 23(10):1502-1511. PMID: 28694328.
      View in: PubMed
    10. Jankowsky E, Harris ME. Mapping specificity landscapes of RNA-protein interactions by high throughput sequencing. Methods. 2017 04 15; 118-119:111-118. PMID: 28263887.
      View in: PubMed
    11. Jain N, Lin HC, Morgan CE, Harris ME, Tolbert BS. Rules of RNA specificity of hnRNP A1 revealed by global and quantitative analysis of its affinity distribution. Proc Natl Acad Sci U S A. 2017 02 28; 114(9):2206-2211. PMID: 28193894.
      View in: PubMed
    12. Harris ME, Anderson VE. Preface. Methods Enzymol. 2017; 596:xv-xviii. PMID: 28911786.
      View in: PubMed
    13. Vijayaraghavan J, Kramp K, Harris ME, van den Akker F. Inhibition of soluble guanylyl cyclase by small molecules targeting the catalytic domain. FEBS Lett. 2016 Oct; 590(20):3669-3680. PMID: 27654641.
      View in: PubMed
    14. Knappenberger AJ, Ahmad MF, Viswanathan R, Dealwis CG, Harris ME. Nucleoside Analogue Triphosphates Allosterically Regulate Human Ribonucleotide Reductase and Identify Chemical Determinants That Drive Substrate Specificity. Biochemistry. 2016 10 18; 55(41):5884-5896. PMID: 27634056.
      View in: PubMed
    15. Lin HC, Zhao J, Niland CN, Tran B, Jankowsky E, Harris ME. Analysis of the RNA Binding Specificity Landscape of C5 Protein Reveals Structure and Sequence Preferences that Direct RNase P Specificity. Cell Chem Biol. 2016 Oct 20; 23(10):1271-1281. PMID: 27693057.
      View in: PubMed
    16. Niland CN, Zhao J, Lin HC, Anderson DR, Jankowsky E, Harris ME. Determination of the Specificity Landscape for Ribonuclease P Processing of Precursor tRNA 5' Leader Sequences. ACS Chem Biol. 2016 08 19; 11(8):2285-92. PMID: 27336323.
      View in: PubMed
    17. Niland CN, Jankowsky E, Harris ME. Optimization of high-throughput sequencing kinetics for determining enzymatic rate constants of thousands of RNA substrates. Anal Biochem. 2016 10 01; 510:1-10. PMID: 27296633.
      View in: PubMed
    18. Misko TA, Wijerathna SR, Radivoyevitch T, Berdis AJ, Ahmad MF, Harris ME, Dealwis CG. Inhibition of yeast ribonucleotide reductase by Sml1 depends on the allosteric state of the enzyme. FEBS Lett. 2016 06; 590(12):1704-12. PMID: 27155231.
      View in: PubMed
    19. Mullins MR, Rajavel M, Hernandez-Sanchez W, de la Fuente M, Biendarra SM, Harris ME, Taylor DJ. POT1-TPP1 Binding and Unfolding of Telomere DNA Discriminates against Structural Polymorphism. J Mol Biol. 2016 07 03; 428(13):2695-708. PMID: 27173378.
      View in: PubMed
    20. Zhang S, Gu H, Chen H, Strong E, Ollie EW, Kellerman D, Liang D, Miyagi M, Anderson VE, Piccirilli JA, York DM, Harris ME. Isotope effect analyses provide evidence for an altered transition state for RNA 2'-O-transphosphorylation catalyzed by Zn(2+). Chem Commun (Camb). 2016 Mar 25; 52(24):4462-5. PMID: 26859380.
      View in: PubMed
    21. Lee TS, Radak BK, Harris ME, York DM. A Two-Metal-Ion-Mediated Conformational Switching Pathway for HDV Ribozyme Activation. ACS Catal. 2016; 6(3):1853-1869. PMID: 27774349.
      View in: PubMed
    22. Ahmad MF, Huff SE, Pink J, Alam I, Zhang A, Perry K, Harris ME, Misko T, Porwal SK, Oleinick NL, Miyagi M, Viswanathan R, Dealwis CG. Identification of Non-nucleoside Human Ribonucleotide Reductase Modulators. J Med Chem. 2015 Dec 24; 58(24):9498-509. PMID: 26488902; PMCID: PMC4751996.
      View in: PubMed, PubMed Central
    23. Harris ME. Theme and Variation in tRNA 5' End Processing Enzymes: Comparative Analysis of Protein versus Ribonucleoprotein RNase P. J Mol Biol. 2016 Jan 16; 428(1):5-9. PMID: 26655024.
      View in: PubMed
    24. Jankowsky E, Harris ME. Specificity and nonspecificity in RNA-protein interactions. Nat Rev Mol Cell Biol. 2015 Sep; 16(9):533-44. PMID: 26285679.
      View in: PubMed
    25. Koo SC, Lu J, Li NS, Leung E, Das SR, Harris ME, Piccirilli JA. Transition State Features in the Hepatitis Delta Virus Ribozyme Reaction Revealed by Atomic Perturbations. J Am Chem Soc. 2015 Jul 22; 137(28):8973-82. PMID: 26125657.
      View in: PubMed
    26. Radak BK, Lee TS, Harris ME, York DM. Assessment of metal-assisted nucleophile activation in the hepatitis delta virus ribozyme from molecular simulation and 3D-RISM. RNA. 2015 Sep; 21(9):1566-77. PMID: 26170378.
      View in: PubMed
    27. Mojica MF, Mahler SG, Bethel CR, Taracila MA, Kosmopoulou M, Papp-Wallace KM, Llarrull LI, Wilson BM, Marshall SH, Wallace CJ, Villegas MV, Harris ME, Vila AJ, Spencer J, Bonomo RA. Exploring the Role of Residue 228 in Substrate and Inhibitor Recognition by VIM Metallo-ß-lactamases. Biochemistry. 2015 May 26; 54(20):3183-96. PMID: 25915520.
      View in: PubMed
    28. Kellerman DL, Simmons KS, Pedraza M, Piccirilli JA, York DM, Harris ME. Determination of hepatitis delta virus ribozyme N(-1) nucleobase and functional group specificity using internal competition kinetics. Anal Biochem. 2015 Aug 15; 483:12-20. PMID: 25937290.
      View in: PubMed
    29. Harris ME, Piccirilli JA, York DM. Integration of kinetic isotope effect analyses to elucidate ribonuclease mechanism. Biochim Biophys Acta. 2015 Nov; 1854(11):1801-8. PMID: 25936517.
      View in: PubMed
    30. Chen H, Piccirilli JA, Harris ME, York DM. Effect of Zn2+ binding and enzyme active site on the transition state for RNA 2'-O-transphosphorylation interpreted through kinetic isotope effects. Biochim Biophys Acta. 2015 Nov; 1854(11):1795-800. PMID: 25812974.
      View in: PubMed
    31. Dissanayake T, Swails JM, Harris ME, Roitberg AE, York DM. Interpretation of pH-activity profiles for acid-base catalysis from molecular simulations. Biochemistry. 2015 Feb 17; 54(6):1307-13. PMID: 25615525.
      View in: PubMed
    32. Porwal SK, Furia E, Harris ME, Viswanathan R, Devireddy L. Synthetic, potentiometric and spectroscopic studies of chelation between Fe(III) and 2,5-DHBA supports salicylate-mode of siderophore binding interactions. J Inorg Biochem. 2015 Apr; 145:1-10. PMID: 25589161.
      View in: PubMed
    33. Chen H, Giese TJ, Huang M, Wong KY, Harris ME, York DM. Mechanistic insights into RNA transphosphorylation from kinetic isotope effects and linear free energy relationships of model reactions. Chemistry. 2014 Oct 27; 20(44):14336-43. PMID: 25223953.
      View in: PubMed
    34. Lin HC, Yandek LE, Gjermeni I, Harris ME. Determination of relative rate constants for in vitro RNA processing reactions by internal competition. Anal Biochem. 2014 Dec 15; 467:54-61. PMID: 25173512.
      View in: PubMed
    35. Kellerman DL, York DM, Piccirilli JA, Harris ME. Altered (transition) states: mechanisms of solution and enzyme catalyzed RNA 2'-O-transphosphorylation. Curr Opin Chem Biol. 2014 Aug; 21:96-102. PMID: 25023967.
      View in: PubMed
    36. Merrick WC, Harris ME. Control not at initiation? Bah, humbug! EMBO J. 2014 Jan 07; 33(1):3-4. PMID: 24363142.
      View in: PubMed
    37. Guenther UP, Yandek LE, Niland CN, Campbell FE, Anderson D, Anderson VE, Harris ME, Jankowsky E. Hidden specificity in an apparently nonspecific RNA-binding protein. Nature. 2013 Oct 17; 502(7471):385-8. PMID: 24056935.
      View in: PubMed
    38. Gu H, Zhang S, Wong KY, Radak BK, Dissanayake T, Kellerman DL, Dai Q, Miyagi M, Anderson VE, York DM, Piccirilli JA, Harris ME. Experimental and computational analysis of the transition state for ribonuclease A-catalyzed RNA 2'-O-transphosphorylation. Proc Natl Acad Sci U S A. 2013 Aug 06; 110(32):13002-7. PMID: 23878223.
      View in: PubMed
    39. Corriveau M, Mullins MR, Baus D, Harris ME, Taylor DJ. Coordinated interactions of multiple POT1-TPP1 proteins with telomere DNA. J Biol Chem. 2013 Jun 07; 288(23):16361-70. PMID: 23616058.
      View in: PubMed
    40. Yandek LE, Lin HC, Harris ME. Alternative substrate kinetics of Escherichia coli ribonuclease P: determination of relative rate constants by internal competition. J Biol Chem. 2013 Mar 22; 288(12):8342-54. PMID: 23362254.
      View in: PubMed
    41. Radak BK, Harris ME, York DM. Molecular simulations of RNA 2'-O-transesterification reaction models in solution. J Phys Chem B. 2013 Jan 10; 117(1):94-103. PMID: 23214417.
      View in: PubMed
    42. Papp-Wallace KM, Senkfor B, Gatta J, Chai W, Taracila MA, Shanmugasundaram V, Han S, Zaniewski RP, Lacey BM, Tomaras AP, Skalweit MJ, Harris ME, Rice LB, Buynak JD, Bonomo RA. Early insights into the interactions of different ß-lactam antibiotics and ß-lactamase inhibitors against soluble forms of Acinetobacter baumannii PBP1a and Acinetobacter sp. PBP3. Antimicrob Agents Chemother. 2012 Nov; 56(11):5687-92. PMID: 22908165.
      View in: PubMed
    43. Levitt PS, Papp-Wallace KM, Taracila MA, Hujer AM, Winkler ML, Smith KM, Xu Y, Harris ME, Bonomo RA. Exploring the role of a conserved class A residue in the O-Loop of KPC-2 ß-lactamase: a mechanism for ceftazidime hydrolysis. J Biol Chem. 2012 Sep 14; 287(38):31783-93. PMID: 22843686.
      View in: PubMed
    44. Wong KY, Gu H, Zhang S, Piccirilli JA, Harris ME, York DM. Characterization of the reaction path and transition states for RNA transphosphorylation models from theory and experiment. Angew Chem Int Ed Engl. 2012 Jan 16; 51(3):647-51. PMID: 22076983.
      View in: PubMed
    45. Lee TS, Giambasu G, Harris ME, York DM. Characterization of the Structure and Dynamics of the HDV Ribozyme at Different Stages Along the Reaction Path. J Phys Chem Lett. 2011 Oct 20; 2(20):2538-2543. PMID: 22200005.
      View in: PubMed
    46. Christian EL, Anderson VE, Harris ME. Deconvolution of Raman spectroscopic signals for electrostatic, H-bonding, and inner-sphere interactions between ions and dimethyl phosphate in solution. J Inorg Biochem. 2011 Apr; 105(4):538-47. PMID: 21334281.
      View in: PubMed
    47. Harris ME, Dai Q, Gu H, Kellerman DL, Piccirilli JA, Anderson VE. Kinetic isotope effects for RNA cleavage by 2'-O- transphosphorylation: nucleophilic activation by specific base. J Am Chem Soc. 2010 Aug 25; 132(33):11613-21. PMID: 20669950.
      View in: PubMed
    48. Christian EL, Anderson VE, Carey PR, Harris ME. A quantitative Raman spectroscopic signal for metal-phosphodiester interactions in solution. Biochemistry. 2010 Apr 06; 49(13):2869-79. PMID: 20180599.
      View in: PubMed
    49. Koutmou KS, Zahler NH, Kurz JC, Campbell FE, Harris ME, Fierke CA. Protein-precursor tRNA contact leads to sequence-specific recognition of 5' leaders by bacterial ribonuclease P. J Mol Biol. 2010 Feb 12; 396(1):195-208. PMID: 19932118.
      View in: PubMed
    50. Sun L, Campbell FE, Yandek LE, Harris ME. Binding of C5 protein to P RNA enhances the rate constant for catalysis for P RNA processing of pre-tRNAs lacking a consensus (+ 1)/C(+ 72) pair. J Mol Biol. 2010 Feb 05; 395(5):1019-37. PMID: 19917291.
      View in: PubMed
    51. Harris ME, Christian EL. RNA crosslinking methods. Methods Enzymol. 2009; 468:127-46. PMID: 20946768.
      View in: PubMed
    52. Harris ME, Cassano AG. Experimental analyses of the chemical dynamics of ribozyme catalysis. Curr Opin Chem Biol. 2008 Dec; 12(6):626-39. PMID: 18952193.
      View in: PubMed
    53. Schroeder LA, Gries TJ, Saecker RM, Record MT, Harris ME, DeHaseth PL. Evidence for a tyrosine-adenine stacking interaction and for a short-lived open intermediate subsequent to initial binding of Escherichia coli RNA polymerase to promoter DNA. J Mol Biol. 2009 Jan 16; 385(2):339-49. PMID: 18976666.
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    54. Dai Q, Frederiksen JK, Anderson VE, Harris ME, Piccirilli JA. Efficient synthesis of [2'-18O]uridine and its incorporation into oligonucleotides: a new tool for mechanistic study of nucleotidyl transfer reactions by isotope effect analysis. J Org Chem. 2008 Jan 04; 73(1):309-11. PMID: 18052189.
      View in: PubMed
    55. Sun L, Harris ME. Evidence that binding of C5 protein to P RNA enhances ribozyme catalysis by influencing active site metal ion affinity. RNA. 2007 Sep; 13(9):1505-15. PMID: 17652407.
      View in: PubMed
    56. Cassano AG, Wang B, Anderson DR, Previs S, Harris ME, Anderson VE. Inaccuracies in selected ion monitoring determination of isotope ratios obviated by profile acquisition: nucleotide 18O/16O measurements. Anal Biochem. 2007 Aug 01; 367(1):28-39. PMID: 17560863.
      View in: PubMed
    57. Sun L, Campbell FE, Zahler NH, Harris ME. Evidence that substrate-specific effects of C5 protein lead to uniformity in binding and catalysis by RNase P. EMBO J. 2006 Sep 06; 25(17):3998-4007. PMID: 16932744.
      View in: PubMed
    58. Anderson VE, Ruszczycky MW, Harris ME. Activation of oxygen nucleophiles in enzyme catalysis. Chem Rev. 2006 Aug; 106(8):3236-51. PMID: 16895326.
      View in: PubMed
    59. Christian EL, Smith KM, Perera N, Harris ME. The P4 metal binding site in RNase P RNA affects active site metal affinity through substrate positioning. RNA. 2006 Aug; 12(8):1463-7. PMID: 16822954.
      View in: PubMed
    60. Guo X, Campbell FE, Sun L, Christian EL, Anderson VE, Harris ME. RNA-dependent folding and stabilization of C5 protein during assembly of the E. coli RNase P holoenzyme. J Mol Biol. 2006 Jun 30; 360(1):190-203. PMID: 16750220.
      View in: PubMed
    61. Zahler NH, Sun L, Christian EL, Harris ME. The pre-tRNA nucleotide base and 2'-hydroxyl at N(-1) contribute to fidelity in tRNA processing by RNase P. J Mol Biol. 2005 Feb 04; 345(5):969-85. PMID: 15644198.
      View in: PubMed
    62. Cassano AG, Anderson VE, Harris ME. Analysis of solvent nucleophile isotope effects: evidence for concerted mechanisms and nucleophilic activation by metal coordination in nonenzymatic and ribozyme-catalyzed phosphodiester hydrolysis. Biochemistry. 2004 Aug 17; 43(32):10547-59. PMID: 15301552.
      View in: PubMed
    63. Cassano AG, Anderson VE, Harris ME. Understanding the transition states of phosphodiester bond cleavage: insights from heavy atom isotope effects. Biopolymers. 2004 Jan; 73(1):110-29. PMID: 14691944.
      View in: PubMed
    64. Harris ME, Christian EL. Recent insights into the structure and function of the ribonucleoprotein enzyme ribonuclease P. Curr Opin Struct Biol. 2003 Jun; 13(3):325-33. PMID: 12831883.
      View in: PubMed
    65. Zahler NH, Christian EL, Harris ME. Recognition of the 5' leader of pre-tRNA substrates by the active site of ribonuclease P. RNA. 2003 Jun; 9(6):734-45. PMID: 12756331; PMCID: PMC1370440.
      View in: PubMed, PubMed Central
    66. Kaye NM, Zahler NH, Christian EL, Harris ME. Conservation of helical structure contributes to functional metal ion interactions in the catalytic domain of ribonuclease P RNA. J Mol Biol. 2002 Nov 29; 324(3):429-42. PMID: 12445779.
      View in: PubMed
    67. Christian EL, Zahler NH, Kaye NM, Harris ME. Analysis of substrate recognition by the ribonucleoprotein endonuclease RNase P. Methods. 2002 Nov; 28(3):307-22. PMID: 12431435.
      View in: PubMed
    68. Cassano AG, Anderson VE, Harris ME. Evidence for direct attack by hydroxide in phosphodiester hydrolysis. J Am Chem Soc. 2002 Sep 18; 124(37):10964-5. PMID: 12224928.
      View in: PubMed
    69. Christian EL, Kaye NM, Harris ME. Evidence for a polynuclear metal ion binding site in the catalytic domain of ribonuclease P RNA. EMBO J. 2002 May 01; 21(9):2253-62. PMID: 11980722; PMCID: PMC125996.
      View in: PubMed, PubMed Central
    70. Kaye NM, Christian EL, Harris ME. NAIM and site-specific functional group modification analysis of RNase P RNA: magnesium dependent structure within the conserved P1-P4 multihelix junction contributes to catalysis. Biochemistry. 2002 Apr 09; 41(14):4533-45. PMID: 11926814.
      View in: PubMed
    71. Campbell FE, Cassano AG, Anderson VE, Harris ME. Pre-steady-state and stopped-flow fluorescence analysis of Escherichia coli ribonuclease III: insights into mechanism and conformational changes associated with binding and catalysis. J Mol Biol. 2002 Mar 15; 317(1):21-40. PMID: 11916377.
      View in: PubMed
    72. Christian EL, Kaye NM, Harris ME. Helix P4 is a divalent metal ion binding site in the conserved core of the ribonuclease P ribozyme. RNA. 2000 Apr; 6(4):511-9. PMID: 10786842.
      View in: PubMed
    73. Christian EL, Harris ME. The track of the pre-tRNA 5' leader in the ribonuclease P ribozyme-substrate complex. Biochemistry. 1999 Sep 28; 38(39):12629-38. PMID: 10504232.
      View in: PubMed
    74. Harris ME, Christian EL. Use of circular permutation and end modification to position photoaffinity probes for analysis of RNA structure. Methods. 1999 May; 18(1):51-9. PMID: 10208816.
      View in: PubMed
    75. Siew D, Zahler NH, Cassano AG, Strobel SA, Harris ME. Identification of adenosine functional groups involved in substrate binding by the ribonuclease P ribozyme. Biochemistry. 1999 Feb 09; 38(6):1873-83. PMID: 10026268.
      View in: PubMed
    76. Christian EL, McPheeters DS, Harris ME. Identification of individual nucleotides in the bacterial ribonuclease P ribozyme adjacent to the pre-tRNA cleavage site by short-range photo-cross-linking. Biochemistry. 1998 Dec 15; 37(50):17618-28. PMID: 9860878.
      View in: PubMed
    77. Chen JL, Nolan JM, Harris ME, Pace NR. Comparative photocross-linking analysis of the tertiary structures of Escherichia coli and Bacillus subtilis RNase P RNAs. EMBO J. 1998 Mar 02; 17(5):1515-25. PMID: 9482748.
      View in: PubMed
    78. Harris ME, Kazantsev AV, Chen JL, Pace NR. Analysis of the tertiary structure of the ribonuclease P ribozyme-substrate complex by site-specific photoaffinity crosslinking. RNA. 1997 Jun; 3(6):561-76. PMID: 9174092.
      View in: PubMed
    79. Harris ME, Pace NR. Identification of phosphates involved in catalysis by the ribozyme RNase P RNA. RNA. 1995 Apr; 1(2):210-8. PMID: 7585250.
      View in: PubMed
    80. Harris ME, Pace NR. Analysis of the tertiary structure of bacterial RNase P RNA. Mol Biol Rep. 1995-1996; 22(2-3):115-23. PMID: 8901497.
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    81. Frank DN, Harris ME, Pace NR. Rational design of self-cleaving pre-tRNA-ribonuclease P RNA conjugates. Biochemistry. 1994 Sep 06; 33(35):10800-8. PMID: 8075082.
      View in: PubMed
    82. Harris ME, Nolan JM, Malhotra A, Brown JW, Harvey SC, Pace NR. Use of photoaffinity crosslinking and molecular modeling to analyze the global architecture of ribonuclease P RNA. EMBO J. 1994 Sep 01; 13(17):3953-63. PMID: 7521297.
      View in: PubMed
    83. Gabb HA, Harris ME, Pandey NB, Marzluff WF, Harvey SC. Molecular modeling to predict the structural and biological effects of mutations in a highly conserved histone mRNA loop sequence. J Biomol Struct Dyn. 1992 Jun; 9(6):1119-30. PMID: 1637506.
      View in: PubMed
    84. Harris ME, Hajduk SL. Kinetoplastid RNA editing: in vitro formation of cytochrome b gRNA-mRNA chimeras from synthetic substrate RNAs. Cell. 1992 Mar 20; 68(6):1091-9. PMID: 1547505.
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