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Michael E. Harris

Title(s)Professor of the Practice of Health Services Administration and Policy
AddressRGL 315
University Park Campus
Los Angeles CA 90089-0626
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    Collapse Overview 
    Collapse Overview
    Mr. Harris joined the University of Southern California as an adjunct faculty member and is now a Professor of the Practice of Health Services Administration and Policy at the Sol Price School of Public Policy at USC.

    Mr. Harris’s focus center on health care issues related to prevention, wellness, and access to care for all populations. He is well versed in the areas of health care reform and the Affordable Care Act. With over 30 years of experience, he is focused on the development of future healthcare delivery models, healthcare innovation and its impact on quality of care concepts.

    Mr. Harris is also a nationally recognized speaker with over 30 years of healthcare experience in the areas of managed care payer and provider contracting, Independent Physician Associations, Management Service Organizations, medical group operations, and management of ancillary services. As one of the nation’s leading authorities on healthcare reform, he advises numerous healthcare organizations on the impact of reform and delivery system adaptability.

    Prior to becoming a leading healthcare consultant, Mr. Harris served in several executive positions responsible for the operational efficiency and performance of healthcare delivery systems.

    His civic involvement includes:

    Commissioner of Sustainability
    City of Palm Springs
    Clinton Health Initiative
    City of Palm Springs
    Regional Access Project Foundation
    Healthy Eating Active Living Network (HEALNet)
    City of Palm Springs

    Collapse Research 
    Collapse Research Activities and Funding
    Specificity in Substrate Recognition and Catalysis by RNA Processing Enzymes
    NIH R35GM127100Jul 5, 2018 - Jun 30, 2023
    Role: Principal Investigator
    Mechanistic Enzymology of Phosphoryl Transfer Enzymes
    NIH R01GM096000Sep 15, 2011 - Feb 28, 2019
    Role: Principal Investigator
    Determination of enzyme isotope effects by tandem ESI-Q/TOF mass spectrometry
    NIH R21GM079647Feb 1, 2007 - Jan 31, 2010
    Role: Principal Investigator
    STOPPED-FLOW CD AND FLUORESCENCE SPECTROMETER
    NIH S10RR014923Mar 1, 2000 - Feb 28, 2001
    Role: Principal Investigator
    Structure and function of RNase P
    NIH R01GM056740Jan 1, 1998 - Dec 31, 2015
    Role: Principal Investigator
    Bridges to Success in the Sciences
    NIH R25GM049010Sep 1, 1993 - Aug 31, 2020
    Role: Co-Principal Investigator
    EUKARYOTIC RIBONUCLEASE P RNA
    NIH F32GM015979Aug 1, 1993
    Role: Principal Investigator
    Graduate Training in Cell and Molecular Biology
    NIH T32GM008056Sep 22, 1983 - Apr 30, 2021
    Role: Co-Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Structure-guided design of anti-cancer ribonucleotide reductase inhibitors. J Enzyme Inhib Med Chem. 2019 Dec; 34(1):438-450. Misko TA, Liu YT, Harris ME, Oleinick NL, Pink J, Lee HY, Dealwis CG. PMID: 30734609.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    2. An Ontology for Facilitating Discussion of Catalytic Strategies of RNA-Cleaving Enzymes. ACS Chem Biol. 2019 06 21; 14(6):1068-1076. Bevilacqua PC, Harris ME, Piccirilli JA, Gaines C, Ganguly A, Kostenbader K, Ekesan S, York DM. PMID: 31095369.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    3. Distributive enzyme binding controlled by local RNA context results in 3' to 5' directional processing of dicistronic tRNA precursors by Escherichia coli ribonuclease P. Nucleic Acids Res. 2019 02 20; 47(3):1451-1467. Zhao J, Harris ME. PMID: 30496557.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    4. Evidence That Nucleophile Deprotonation Exceeds Bond Formation in the HDV Ribozyme Transition State. Biochemistry. 2018 06 26; 57(25):3465-3472. Lu J, Koo SC, Weissman BP, Harris ME, Li NS, Piccirilli JA. PMID: 29733591.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Structure-Guided Synthesis and Mechanistic Studies Reveal Sweetspots on Naphthyl Salicyl Hydrazone Scaffold as Non-Nucleosidic Competitive, Reversible Inhibitors of Human Ribonucleotide Reductase. J Med Chem. 2018 02 08; 61(3):666-680. Huff SE, Mohammed FA, Yang M, Agrawal P, Pink J, Harris ME, Dealwis CG, Viswanathan R. PMID: 29253340.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. Kinetic Isotope Effect Analysis of RNA 2'-O-Transphosphorylation. Methods Enzymol. 2017; 596:433-457. Harris ME, York DM, Piccirilli JA, Anderson VE. PMID: 28911780.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    7. Phylogenetic sequence analysis and functional studies reveal compensatory amino acid substitutions in loop 2 of human ribonucleotide reductase. J Biol Chem. 2017 10 06; 292(40):16463-16476. Knappenberger AJ, Grandhi S, Sheth R, Ahmad MF, Viswanathan R, Harris ME. PMID: 28808063.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    8. Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule. Proc Natl Acad Sci U S A. 2017 08 01; 114(31):8241-8246. Ahmad MF, Alam I, Huff SE, Pink J, Flanagan SA, Shewach D, Misko TA, Oleinick NL, Harte WE, Viswanathan R, Harris ME, Dealwis CG. PMID: 28716944.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    9. The contribution of the C5 protein subunit of Escherichia coli ribonuclease P to specificity for precursor tRNA is modulated by proximal 5' leader sequences. RNA. 2017 10; 23(10):1502-1511. Niland CN, Anderson DR, Jankowsky E, Harris ME. PMID: 28694328.
      View in: PubMed   Mentions: 3     Fields:    
    10. Mapping specificity landscapes of RNA-protein interactions by high throughput sequencing. Methods. 2017 04 15; 118-119:111-118. Jankowsky E, Harris ME. PMID: 28263887.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    11. Rules of RNA specificity of hnRNP A1 revealed by global and quantitative analysis of its affinity distribution. Proc Natl Acad Sci U S A. 2017 02 28; 114(9):2206-2211. Jain N, Lin HC, Morgan CE, Harris ME, Tolbert BS. PMID: 28193894.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    12. Preface. Methods Enzymol. 2017; 596:xv-xviii. Harris ME, Anderson VE. PMID: 28911786.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    13. Inhibition of soluble guanylyl cyclase by small molecules targeting the catalytic domain. FEBS Lett. 2016 Oct; 590(20):3669-3680. Vijayaraghavan J, Kramp K, Harris ME, van den Akker F. PMID: 27654641.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    14. Nucleoside Analogue Triphosphates Allosterically Regulate Human Ribonucleotide Reductase and Identify Chemical Determinants That Drive Substrate Specificity. Biochemistry. 2016 10 18; 55(41):5884-5896. Knappenberger AJ, Ahmad MF, Viswanathan R, Dealwis CG, Harris ME. PMID: 27634056.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    15. Analysis of the RNA Binding Specificity Landscape of C5 Protein Reveals Structure and Sequence Preferences that Direct RNase P Specificity. Cell Chem Biol. 2016 Oct 20; 23(10):1271-1281. Lin HC, Zhao J, Niland CN, Tran B, Jankowsky E, Harris ME. PMID: 27693057.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    16. Determination of the Specificity Landscape for Ribonuclease P Processing of Precursor tRNA 5' Leader Sequences. ACS Chem Biol. 2016 08 19; 11(8):2285-92. Niland CN, Zhao J, Lin HC, Anderson DR, Jankowsky E, Harris ME. PMID: 27336323.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    17. Optimization of high-throughput sequencing kinetics for determining enzymatic rate constants of thousands of RNA substrates. Anal Biochem. 2016 10 01; 510:1-10. Niland CN, Jankowsky E, Harris ME. PMID: 27296633.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    18. Inhibition of yeast ribonucleotide reductase by Sml1 depends on the allosteric state of the enzyme. FEBS Lett. 2016 06; 590(12):1704-12. Misko TA, Wijerathna SR, Radivoyevitch T, Berdis AJ, Ahmad MF, Harris ME, Dealwis CG. PMID: 27155231.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    19. POT1-TPP1 Binding and Unfolding of Telomere DNA Discriminates against Structural Polymorphism. J Mol Biol. 2016 07 03; 428(13):2695-708. Mullins MR, Rajavel M, Hernandez-Sanchez W, de la Fuente M, Biendarra SM, Harris ME, Taylor DJ. PMID: 27173378.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    20. Isotope effect analyses provide evidence for an altered transition state for RNA 2'-O-transphosphorylation catalyzed by Zn(2+). Chem Commun (Camb). 2016 Mar 25; 52(24):4462-5. Zhang S, Gu H, Chen H, Strong E, Ollie EW, Kellerman D, Liang D, Miyagi M, Anderson VE, Piccirilli JA, York DM, Harris ME. PMID: 26859380.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    21. A Two-Metal-Ion-Mediated Conformational Switching Pathway for HDV Ribozyme Activation. ACS Catal. 2016; 6(3):1853-1869. Lee TS, Radak BK, Harris ME, York DM. PMID: 27774349.
      View in: PubMed   Mentions:
    22. Identification of Non-nucleoside Human Ribonucleotide Reductase Modulators. J Med Chem. 2015 Dec 24; 58(24):9498-509. Ahmad MF, Huff SE, Pink J, Alam I, Zhang A, Perry K, Harris ME, Misko T, Porwal SK, Oleinick NL, Miyagi M, Viswanathan R, Dealwis CG. PMID: 26488902.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    23. Theme and Variation in tRNA 5' End Processing Enzymes: Comparative Analysis of Protein versus Ribonucleoprotein RNase P. J Mol Biol. 2016 Jan 16; 428(1):5-9. Harris ME. PMID: 26655024.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    24. Specificity and nonspecificity in RNA-protein interactions. Nat Rev Mol Cell Biol. 2015 Sep; 16(9):533-44. Jankowsky E, Harris ME. PMID: 26285679.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    25. Transition State Features in the Hepatitis Delta Virus Ribozyme Reaction Revealed by Atomic Perturbations. J Am Chem Soc. 2015 Jul 22; 137(28):8973-82. Koo SC, Lu J, Li NS, Leung E, Das SR, Harris ME, Piccirilli JA. PMID: 26125657.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    26. Assessment of metal-assisted nucleophile activation in the hepatitis delta virus ribozyme from molecular simulation and 3D-RISM. RNA. 2015 Sep; 21(9):1566-77. Radak BK, Lee TS, Harris ME, York DM. PMID: 26170378.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    27. Exploring the Role of Residue 228 in Substrate and Inhibitor Recognition by VIM Metallo-ß-lactamases. Biochemistry. 2015 May 26; 54(20):3183-96. Mojica MF, Mahler SG, Bethel CR, Taracila MA, Kosmopoulou M, Papp-Wallace KM, Llarrull LI, Wilson BM, Marshall SH, Wallace CJ, Villegas MV, Harris ME, Vila AJ, Spencer J, Bonomo RA. PMID: 25915520.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    28. Determination of hepatitis delta virus ribozyme N(-1) nucleobase and functional group specificity using internal competition kinetics. Anal Biochem. 2015 Aug 15; 483:12-20. Kellerman DL, Simmons KS, Pedraza M, Piccirilli JA, York DM, Harris ME. PMID: 25937290.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    29. Integration of kinetic isotope effect analyses to elucidate ribonuclease mechanism. Biochim Biophys Acta. 2015 Nov; 1854(11):1801-8. Harris ME, Piccirilli JA, York DM. PMID: 25936517.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    30. Effect of Zn2+ binding and enzyme active site on the transition state for RNA 2'-O-transphosphorylation interpreted through kinetic isotope effects. Biochim Biophys Acta. 2015 Nov; 1854(11):1795-800. Chen H, Piccirilli JA, Harris ME, York DM. PMID: 25812974.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    31. Interpretation of pH-activity profiles for acid-base catalysis from molecular simulations. Biochemistry. 2015 Feb 17; 54(6):1307-13. Dissanayake T, Swails JM, Harris ME, Roitberg AE, York DM. PMID: 25615525.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    32. Synthetic, potentiometric and spectroscopic studies of chelation between Fe(III) and 2,5-DHBA supports salicylate-mode of siderophore binding interactions. J Inorg Biochem. 2015 Apr; 145:1-10. Porwal SK, Furia E, Harris ME, Viswanathan R, Devireddy L. PMID: 25589161.
      View in: PubMed   Mentions: 2     Fields:    
    33. Mechanistic insights into RNA transphosphorylation from kinetic isotope effects and linear free energy relationships of model reactions. Chemistry. 2014 Oct 27; 20(44):14336-43. Chen H, Giese TJ, Huang M, Wong KY, Harris ME, York DM. PMID: 25223953.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    34. Determination of relative rate constants for in vitro RNA processing reactions by internal competition. Anal Biochem. 2014 Dec 15; 467:54-61. Lin HC, Yandek LE, Gjermeni I, Harris ME. PMID: 25173512.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    35. Altered (transition) states: mechanisms of solution and enzyme catalyzed RNA 2'-O-transphosphorylation. Curr Opin Chem Biol. 2014 Aug; 21:96-102. Kellerman DL, York DM, Piccirilli JA, Harris ME. PMID: 25023967.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    36. Control not at initiation? Bah, humbug! EMBO J. 2014 Jan 07; 33(1):3-4. Merrick WC, Harris ME. PMID: 24363142.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    37. Hidden specificity in an apparently nonspecific RNA-binding protein. Nature. 2013 Oct 17; 502(7471):385-8. Guenther UP, Yandek LE, Niland CN, Campbell FE, Anderson D, Anderson VE, Harris ME, Jankowsky E. PMID: 24056935.
      View in: PubMed   Mentions: 34     Fields:    Translation:Cells
    38. Experimental and computational analysis of the transition state for ribonuclease A-catalyzed RNA 2'-O-transphosphorylation. Proc Natl Acad Sci U S A. 2013 Aug 06; 110(32):13002-7. Gu H, Zhang S, Wong KY, Radak BK, Dissanayake T, Kellerman DL, Dai Q, Miyagi M, Anderson VE, York DM, Piccirilli JA, Harris ME. PMID: 23878223.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    39. Coordinated interactions of multiple POT1-TPP1 proteins with telomere DNA. J Biol Chem. 2013 Jun 07; 288(23):16361-16370. Corriveau M, Mullins MR, Baus D, Harris ME, Taylor DJ. PMID: 23616058.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    40. Alternative substrate kinetics of Escherichia coli ribonuclease P: determination of relative rate constants by internal competition. J Biol Chem. 2013 Mar 22; 288(12):8342-8354. Yandek LE, Lin HC, Harris ME. PMID: 23362254.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    41. Molecular simulations of RNA 2'-O-transesterification reaction models in solution. J Phys Chem B. 2013 Jan 10; 117(1):94-103. Radak BK, Harris ME, York DM. PMID: 23214417.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    42. Early insights into the interactions of different ß-lactam antibiotics and ß-lactamase inhibitors against soluble forms of Acinetobacter baumannii PBP1a and Acinetobacter sp. PBP3. Antimicrob Agents Chemother. 2012 Nov; 56(11):5687-92. Papp-Wallace KM, Senkfor B, Gatta J, Chai W, Taracila MA, Shanmugasundaram V, Han S, Zaniewski RP, Lacey BM, Tomaras AP, Skalweit MJ, Harris ME, Rice LB, Buynak JD, Bonomo RA. PMID: 22908165.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    43. Exploring the role of a conserved class A residue in the O-Loop of KPC-2 ß-lactamase: a mechanism for ceftazidime hydrolysis. J Biol Chem. 2012 Sep 14; 287(38):31783-93. Levitt PS, Papp-Wallace KM, Taracila MA, Hujer AM, Winkler ML, Smith KM, Xu Y, Harris ME, Bonomo RA. PMID: 22843686.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    44. Characterization of the reaction path and transition states for RNA transphosphorylation models from theory and experiment. Angew Chem Int Ed Engl. 2012 Jan 16; 51(3):647-51. Wong KY, Gu H, Zhang S, Piccirilli JA, Harris ME, York DM. PMID: 22076983.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    45. Characterization of the Structure and Dynamics of the HDV Ribozyme at Different Stages Along the Reaction Path. J Phys Chem Lett. 2011 Oct 20; 2(20):2538-2543. Lee TS, Giambasu G, Harris ME, York DM. PMID: 22200005.
      View in: PubMed   Mentions: 16     Fields:    
    46. Deconvolution of Raman spectroscopic signals for electrostatic, H-bonding, and inner-sphere interactions between ions and dimethyl phosphate in solution. J Inorg Biochem. 2011 Apr; 105(4):538-47. Christian EL, Anderson VE, Harris ME. PMID: 21334281.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    47. Kinetic isotope effects for RNA cleavage by 2'-O- transphosphorylation: nucleophilic activation by specific base. J Am Chem Soc. 2010 Aug 25; 132(33):11613-21. Harris ME, Dai Q, Gu H, Kellerman DL, Piccirilli JA, Anderson VE. PMID: 20669950.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    48. A quantitative Raman spectroscopic signal for metal-phosphodiester interactions in solution. Biochemistry. 2010 Apr 06; 49(13):2869-79. Christian EL, Anderson VE, Carey PR, Harris ME. PMID: 20180599.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    49. Protein-precursor tRNA contact leads to sequence-specific recognition of 5' leaders by bacterial ribonuclease P. J Mol Biol. 2010 Feb 12; 396(1):195-208. Koutmou KS, Zahler NH, Kurz JC, Campbell FE, Harris ME, Fierke CA. PMID: 19932118.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    50. Binding of C5 protein to P RNA enhances the rate constant for catalysis for P RNA processing of pre-tRNAs lacking a consensus (+ 1)/C(+ 72) pair. J Mol Biol. 2010 Feb 05; 395(5):1019-37. Sun L, Campbell FE, Yandek LE, Harris ME. PMID: 19917291.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    51. RNA crosslinking methods. Methods Enzymol. 2009; 468:127-46. Harris ME, Christian EL. PMID: 20946768.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    52. Experimental analyses of the chemical dynamics of ribozyme catalysis. Curr Opin Chem Biol. 2008 Dec; 12(6):626-39. Harris ME, Cassano AG. PMID: 18952193.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    53. Evidence for a tyrosine-adenine stacking interaction and for a short-lived open intermediate subsequent to initial binding of Escherichia coli RNA polymerase to promoter DNA. J Mol Biol. 2009 Jan 16; 385(2):339-49. Schroeder LA, Gries TJ, Saecker RM, Record MT, Harris ME, DeHaseth PL. PMID: 18976666.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    54. Efficient synthesis of [2'-18O]uridine and its incorporation into oligonucleotides: a new tool for mechanistic study of nucleotidyl transfer reactions by isotope effect analysis. J Org Chem. 2008 Jan 04; 73(1):309-11. Dai Q, Frederiksen JK, Anderson VE, Harris ME, Piccirilli JA. PMID: 18052189.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    55. Evidence that binding of C5 protein to P RNA enhances ribozyme catalysis by influencing active site metal ion affinity. RNA. 2007 Sep; 13(9):1505-15. Sun L, Harris ME. PMID: 17652407.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    56. Inaccuracies in selected ion monitoring determination of isotope ratios obviated by profile acquisition: nucleotide 18O/16O measurements. Anal Biochem. 2007 Aug 01; 367(1):28-39. Cassano AG, Wang B, Anderson DR, Previs S, Harris ME, Anderson VE. PMID: 17560863.
      View in: PubMed   Mentions: 9     Fields:    
    57. Evidence that substrate-specific effects of C5 protein lead to uniformity in binding and catalysis by RNase P. EMBO J. 2006 Sep 06; 25(17):3998-4007. Sun L, Campbell FE, Zahler NH, Harris ME. PMID: 16932744.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
    58. Activation of oxygen nucleophiles in enzyme catalysis. Chem Rev. 2006 Aug; 106(8):3236-51. Anderson VE, Ruszczycky MW, Harris ME. PMID: 16895326.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    59. The P4 metal binding site in RNase P RNA affects active site metal affinity through substrate positioning. RNA. 2006 Aug; 12(8):1463-7. Christian EL, Smith KM, Perera N, Harris ME. PMID: 16822954.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    60. RNA-dependent folding and stabilization of C5 protein during assembly of the E. coli RNase P holoenzyme. J Mol Biol. 2006 Jun 30; 360(1):190-203. Guo X, Campbell FE, Sun L, Christian EL, Anderson VE, Harris ME. PMID: 16750220.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    61. The pre-tRNA nucleotide base and 2'-hydroxyl at N(-1) contribute to fidelity in tRNA processing by RNase P. J Mol Biol. 2005 Feb 04; 345(5):969-85. Zahler NH, Sun L, Christian EL, Harris ME. PMID: 15644198.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    62. Analysis of solvent nucleophile isotope effects: evidence for concerted mechanisms and nucleophilic activation by metal coordination in nonenzymatic and ribozyme-catalyzed phosphodiester hydrolysis. Biochemistry. 2004 Aug 17; 43(32):10547-59. Cassano AG, Anderson VE, Harris ME. PMID: 15301552.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    63. Understanding the transition states of phosphodiester bond cleavage: insights from heavy atom isotope effects. Biopolymers. 2004 Jan; 73(1):110-29. Cassano AG, Anderson VE, Harris ME. PMID: 14691944.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    64. Recent insights into the structure and function of the ribonucleoprotein enzyme ribonuclease P. Curr Opin Struct Biol. 2003 Jun; 13(3):325-33. Harris ME, Christian EL. PMID: 12831883.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    65. Recognition of the 5' leader of pre-tRNA substrates by the active site of ribonuclease P. RNA. 2003 Jun; 9(6):734-45. Zahler NH, Christian EL, Harris ME. PMID: 12756331.
      View in: PubMed   Mentions: 32     Fields:    Translation:Cells
    66. Conservation of helical structure contributes to functional metal ion interactions in the catalytic domain of ribonuclease P RNA. J Mol Biol. 2002 Nov 29; 324(3):429-42. Kaye NM, Zahler NH, Christian EL, Harris ME. PMID: 12445779.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    67. Analysis of substrate recognition by the ribonucleoprotein endonuclease RNase P. Methods. 2002 Nov; 28(3):307-22. Christian EL, Zahler NH, Kaye NM, Harris ME. PMID: 12431435.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    68. Evidence for direct attack by hydroxide in phosphodiester hydrolysis. J Am Chem Soc. 2002 Sep 18; 124(37):10964-5. Cassano AG, Anderson VE, Harris ME. PMID: 12224928.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    69. Evidence for a polynuclear metal ion binding site in the catalytic domain of ribonuclease P RNA. EMBO J. 2002 May 01; 21(9):2253-62. Christian EL, Kaye NM, Harris ME. PMID: 11980722.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    70. NAIM and site-specific functional group modification analysis of RNase P RNA: magnesium dependent structure within the conserved P1-P4 multihelix junction contributes to catalysis. Biochemistry. 2002 Apr 09; 41(14):4533-45. Kaye NM, Christian EL, Harris ME. PMID: 11926814.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    71. Pre-steady-state and stopped-flow fluorescence analysis of Escherichia coli ribonuclease III: insights into mechanism and conformational changes associated with binding and catalysis. J Mol Biol. 2002 Mar 15; 317(1):21-40. Campbell FE, Cassano AG, Anderson VE, Harris ME. PMID: 11916377.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    72. Helix P4 is a divalent metal ion binding site in the conserved core of the ribonuclease P ribozyme. RNA. 2000 Apr; 6(4):511-9. Christian EL, Kaye NM, Harris ME. PMID: 10786842.
      View in: PubMed   Mentions: 25     Fields:    Translation:Cells
    73. The track of the pre-tRNA 5' leader in the ribonuclease P ribozyme-substrate complex. Biochemistry. 1999 Sep 28; 38(39):12629-38. Christian EL, Harris ME. PMID: 10504232.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    74. Use of circular permutation and end modification to position photoaffinity probes for analysis of RNA structure. Methods. 1999 May; 18(1):51-9. Harris ME, Christian EL. PMID: 10208816.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    75. Identification of adenosine functional groups involved in substrate binding by the ribonuclease P ribozyme. Biochemistry. 1999 Feb 09; 38(6):1873-83. Siew D, Zahler NH, Cassano AG, Strobel SA, Harris ME. PMID: 10026268.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    76. Identification of individual nucleotides in the bacterial ribonuclease P ribozyme adjacent to the pre-tRNA cleavage site by short-range photo-cross-linking. Biochemistry. 1998 Dec 15; 37(50):17618-28. Christian EL, McPheeters DS, Harris ME. PMID: 9860878.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    77. Comparative photocross-linking analysis of the tertiary structures of Escherichia coli and Bacillus subtilis RNase P RNAs. EMBO J. 1998 Mar 02; 17(5):1515-25. Chen JL, Nolan JM, Harris ME, Pace NR. PMID: 9482748.
      View in: PubMed   Mentions: 42     Fields:    Translation:Cells
    78. Analysis of the tertiary structure of the ribonuclease P ribozyme-substrate complex by site-specific photoaffinity crosslinking. RNA. 1997 Jun; 3(6):561-76. Harris ME, Kazantsev AV, Chen JL, Pace NR. PMID: 9174092.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
    79. Identification of phosphates involved in catalysis by the ribozyme RNase P RNA. RNA. 1995 Apr; 1(2):210-8. Harris ME, Pace NR. PMID: 7585250.
      View in: PubMed   Mentions: 38     Fields:    Translation:Cells
    80. Analysis of the tertiary structure of bacterial RNase P RNA. Mol Biol Rep. 1995-1996; 22(2-3):115-23. Harris ME, Pace NR. PMID: 8901497.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    81. Rational design of self-cleaving pre-tRNA-ribonuclease P RNA conjugates. Biochemistry. 1994 Sep 06; 33(35):10800-8. Frank DN, Harris ME, Pace NR. PMID: 8075082.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    82. Use of photoaffinity crosslinking and molecular modeling to analyze the global architecture of ribonuclease P RNA. EMBO J. 1994 Sep 01; 13(17):3953-63. Harris ME, Nolan JM, Malhotra A, Brown JW, Harvey SC, Pace NR. PMID: 7521297.
      View in: PubMed   Mentions: 55     Fields:    Translation:Cells
    83. Molecular modeling to predict the structural and biological effects of mutations in a highly conserved histone mRNA loop sequence. J Biomol Struct Dyn. 1992 Jun; 9(6):1119-30. Gabb HA, Harris ME, Pandey NB, Marzluff WF, Harvey SC. PMID: 1637506.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    84. Kinetoplastid RNA editing: in vitro formation of cytochrome b gRNA-mRNA chimeras from synthetic substrate RNAs. Cell. 1992 Mar 20; 68(6):1091-9. Harris ME, Hajduk SL. PMID: 1547505.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
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