Keith Hazleton

Photo of Keith Hazleton
Title(s)Assistant Professor of Clinical Pediatrics
SchoolKeck School of Medicine of Usc
ORCID ORCID Icon0000-0003-4098-3411 Additional info
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    Keith Hazleton, MD, PhD is a pediatric hepatologist in the Division of Gastroenterology, Hepatology and Nutrition at Children's Hospital Los Angeles and Assistant Professor of Clinical Pediatrics at the Keck School of Medicine of USC. His research interests include gut microbiome dysbiosis in pediatric disease, with a focus on diet-microbiome interactions in Clostridioides difficile infection and emerging work on the gut-liver axis in biliary atresia. His PhD training at Albert Einstein College of Medicine focused on purine salvage pathway enzymology and transition state analogue inhibitor development targeting Plasmodium falciparum.

    Dr. Hazleton is dedicated to mentoring medical students, residents, and fellows in pediatric gastroenterology and hepatology. He serves on the NASPGHAN Research Committee, where he previously co-chaired the Grants Subcommittee and currently serves on the Abstracts Subcommittee.

    Collapse Biography 
    Collapse education and training
    Oregon State University , Corvallis, ORBS04/2002Biochemistry/Biophysics
    The Albert Einstein College of Medicine, Bronx, NYMD05/2013Medicine
    The Albert Einstein College of Medicine, Bronx, NYPhD05/2013Biomedical Science
    Children's Hospital Colorado/University of Colorado , Aurora, CO06/2015General Pediatrics
    Children's Hospital Colorado/University of Colorado , Aurora, CO06/2019Pediatric Gastroenterology
    Children's Hospital Colorado/University of Colorado , Aurora, CO06/2020Pediatric Advanced/Transplant Hepatology
    Collapse awards and honors
    American Gastroenterological Association Institute2019Gut Microbiota for Health World Summit Travel Award
    Front Range Microbiome Symposium2019Best Contributed Presentation

    Collapse Research 
    Collapse Featured Publications
    Collapse research activities and funding
    Dietary and synbiotic strategy to limit gut microbiome dysbiosis and protect against Clostridioides difficile infection
    NIH U01AI150589Apr 23, 2021 - Mar 31, 2026
    Role: Co-Investigator

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    Collapse Bibliographic 
    Collapse publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Nudix hydrolase 15 deficiency and azathioprine toxicity in a liver transplant recipient: A case report. JPGN Rep. 2026 Oct 14. Nguyen JQ, Rodriguez N, Chapman KA, Deardorff MA, Hazleton KZ. PMID: 42877613; PMCID: PMC13662887.
      View in: PubMed   Mentions:
    2. An international multicenter analysis of the outcome of pediatric first variceal hemorrhage. Hepatology. 2026 Oct 07. Shneider BL, Gao X, Guo K, Jaramillo C, Molleston JP, Pimenta J, Superina R, Ferreira A, Gumm AJ, Aqul A, Feldman AG, Di Giorgio A, Pai AK, Novak AP, Gardin A, Jimenez-Rivera C, Amaro-Reynoso CU, Desai C, Voroniak D, Aldrian D, Bannister E, Shteyer E, Vogel GF, Indolfi G, van der Doef HPJ, Squires JE, Hartley JL, Gana JC, Quintero-Bernabéu J, Taylor J, Sweeny K, Chew KS, Hazleton KZ, Bass LM, Mercadal-Hally M, Durilova M, Homan M, Martinez M, Kehar M, Kasahara M, Godik O, Waisbourd-Zinman O, Valentino PL, Spector PR, Fawaz R, Vázquez-Frias R, Yuldashev R, Komine R, Kulkarni S, Ibrahim SH, Bedoyan S, Smith SK, Elisofon SA, Lam S, Yokoyama S, Carrera S, Getsuwan S, Treepongkaruna S, Berkenfeld S, Kotsou T, Goldman D, Slowik V, Lee WS, Karnsakul W, Hardikar W, Mozer-Glassberg Y, De Franchis R, Ackermann O, Grammatikopoulos T. PMID: 42842335.
      View in: PubMed   Mentions:
    3. Dietary fiber reduces mortality from secondary sepsis in a murine model of Clostridioides difficile infection. iScience. 2026 Apr 17; 29(4):115258. Apgar M, Wall ES, Midura-Kiela M, Neff CP, Orlicky DJ, Lyon LM, Bernardazzi C, Martin CG, Gordon OM, Jimenez-Espinoza I, Flynn JK, Lozupone CA, Hazleton KZ. PMID: 41907412; PMCID: PMC13018909.
      View in: PubMed   Mentions:
    4. The Impact of Diet on Clostridioides difficile Infection: A Review. J Infect Dis. 2025 Jul 11; 231(6):e1010-e1018. Castro M, Silver HJ, Hazleton K, Lozupone C, Nicholson MR. PMID: 40321029; PMCID: PMC12247793.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    5. A Multimodal Intervention to Reduce C. difficile Infections and Stool Testing. Pediatrics. 2024 Mar 01; 153(3). Cotter JM, Stokes CL, Tong S, Birkholz M, Child J, Cost C, Coughlin R, Cox S, Dolan SA, Dorris K, Hazleton KZ, Lugo V, Norcross M, Pearce K, Dominguez SR. PMID: 38352983; PMCID: PMC11360068.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    6. Dietary fat promotes antibiotic-induced Clostridioides difficile mortality in mice. NPJ Biofilms Microbiomes. 2022 04 01; 8(1):15. Hazleton KZ, Martin CG, Orlicky DJ, Arnolds KL, Nusbacher NM, Moreno-Huizar N, Armstrong M, Reisdorph N, Lozupone CA. PMID: 35365681; PMCID: PMC8975876.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    7. Gastric injury secondary to button battery ingestions: a retrospective multicenter review. Gastrointest Endosc. 2020 Aug; 92(2):276-283. Khalaf RT, Ruan W, Orkin S, Wilsey M, Fishman DS, Mallon D, Pan Z, Hazleton KZ, Kramer RE, Walker T. PMID: 32334020; PMCID: PMC7422336.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    8. Multiple-Ascending-Dose Phase 1 Clinical Study of the Safety, Tolerability, and Pharmacokinetics of CRS3123, a Narrow-Spectrum Agent with Minimal Disruption of Normal Gut Microbiota. Antimicrob Agents Chemother. 2019 12 20; 64(1). Lomeli BK, Galbraith H, Schettler J, Saviolakis GA, El-Amin W, Osborn B, Ravel J, Hazleton K, Lozupone CA, Evans RJ, Bell SJ, Ochsner UA, Jarvis TC, Baqar S, Janjic N. PMID: 31685472; PMCID: PMC7187627.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCellsCTClinical Trials
    9. Low diversity gut microbiota dysbiosis: drivers, functional implications and recovery. Curr Opin Microbiol. 2018 08; 44:34-40. Kriss M, Hazleton KZ, Nusbacher NM, Martin CG, Lozupone CA. PMID: 30036705; PMCID: PMC6435260.
      View in: PubMed   Mentions: 214     Fields:    Translation:HumansAnimalsCells
    10. Transition state analogues of Plasmodium falciparum and human orotate phosphoribosyltransferases. J Biol Chem. 2013 Nov 29; 288(48):34746-54. Zhang Y, Evans GB, Clinch K, Crump DR, Harris LD, Fröhlich RF, Tyler PC, Hazleton KZ, Cassera MB, Schramm VL. PMID: 24158442; PMCID: PMC3843086.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    11. Acyclic phosph(on)ate inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase. Bioorg Med Chem. 2013 Sep 01; 21(17):5629-46. Clinch K, Crump DR, Evans GB, Hazleton KZ, Mason JM, Schramm VL, Tyler PC. PMID: 23810424; PMCID: PMC3740065.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    12. Acyclic immucillin phosphonates: second-generation inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase. Chem Biol. 2012 Jun 22; 19(6):721-30. Hazleton KZ, Ho MC, Cassera MB, Clinch K, Crump DR, Rosario I, Merino EF, Almo SC, Tyler PC, Schramm VL. PMID: 22726686; PMCID: PMC3397391.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    13. Plasmodium falciparum parasites are killed by a transition state analogue of purine nucleoside phosphorylase in a primate animal model. PLoS One. 2011; 6(11):e26916. Cassera MB, Hazleton KZ, Merino EF, Obaldia N, Ho MC, Murkin AS, DePinto R, Gutierrez JA, Almo SC, Evans GB, Babu YS, Schramm VL. PMID: 22096507; PMCID: PMC3214022.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    14. Purine and pyrimidine pathways as targets in Plasmodium falciparum. Curr Top Med Chem. 2011; 11(16):2103-15. Cassera MB, Zhang Y, Hazleton KZ, Schramm VL. PMID: 21619511; PMCID: PMC3319363.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    15. Transport of purines and purine salvage pathway inhibitors by the Plasmodium falciparum equilibrative nucleoside transporter PfENT1. Mol Biochem Parasitol. 2010 Jan; 169(1):40-9. Riegelhaupt PM, Cassera MB, Fröhlich RF, Hazleton KZ, Hefter JJ, Schramm VL, Akabas MH. PMID: 19818813; PMCID: PMC2783484.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    16. Erythrocytic adenosine monophosphate as an alternative purine source in Plasmodium falciparum. J Biol Chem. 2008 Nov 21; 283(47):32889-99. Cassera MB, Hazleton KZ, Riegelhaupt PM, Merino EF, Luo M, Akabas MH, Schramm VL. PMID: 18799466; PMCID: PMC2583302.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    17. Anopheles gambiae purine nucleoside phosphorylase: catalysis, structure, and inhibition. Biochemistry. 2007 Oct 30; 46(43):12405-15. Taylor EA, Rinaldo-Matthis A, Li L, Ghanem M, Hazleton KZ, Cassera MB, Almo SC, Schramm VL. PMID: 17918964.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    18. Structural characterization of the fusion of two pentapeptide repeat proteins, Np275 and Np276, from Nostoc punctiforme: resurrection of an ancestral protein. Protein Sci. 2007 Apr; 16(4):755-60. Vetting MW, Hegde SS, Hazleton KZ, Blanchard JS. PMID: 17384236; PMCID: PMC2203339.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
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