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Karen Ting Chang, PhD

TitleAssociate Professor of Physiology and Neuroscience
InstitutionUniversity of Southern California
DepartmentZilkha Neurogenetic Institute
AddressZNI 219, 1501 San Pablo Street
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 1871
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    Collapse Research 
    Collapse Research Activities and Funding
    (PQ#9): Altered mitochondrial transport and chemotherapy-induced peripheral neuropathy
    NIH/NCI R21CA215985Apr 1, 2017 - Mar 31, 2019
    Role: Principal Investigator
    Role of DYRK1A/MNB in Synaptic growth and function
    NIH/NINDS R01NS080946Jul 16, 2013 - Jun 30, 2018
    Role: Principal Investigator
    Role of nebula/DSCR1 in mitochondria
    NIH/NINDS R00NS052524Sep 19, 2007 - Aug 31, 2013
    Role: Principal Investigator
    Role of nebula/DSCR1 in mitochondria
    NIH/NINDS K99NS052524Sep 19, 2007 - Aug 31, 2009
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Lee JY, Geng J, Lee J, Wang AR, Chang K. Activity-Induced Synaptic Structural Modifications by an Activator of Integrin Signaling at the Drosophila Neuromuscular Junction. J Neurosci. 2017 Mar 22; 37(12):3246-3263. PMID: 28219985.
      View in: PubMed
    2. Geng J, Wang L, Lee JY, Chen CK, Chang K. Phosphorylation of Synaptojanin Differentially Regulates Endocytosis of Functionally Distinct Synaptic Vesicle Pools. J Neurosci. 2016 08 24; 36(34):8882-94. PMID: 27559170; PMCID: PMC4995302 [Available on 02/24/17].
      View in: PubMed, PubMed Central
    3. Lee JY, Chen JY, Shaw JL, Chang K. Maintenance of Stem Cell Niche Integrity by a Novel Activator of Integrin Signaling. PLoS Genet. 2016 May; 12(5):e1006043. PMID: 27191715; PMCID: PMC4871447.
      View in: PubMed, PubMed Central
    4. Wang W, Rai A, Hur EM, Smilansky Z, Chang K, Min KT. DSCR1 is required for both axonal growth cone extension and steering. J Cell Biol. 2016 05 23; 213(4):451-62. PMID: 27185837.
      View in: PubMed
    5. Niescier RF, Kwak SK, Joo SH, Chang K, Min KT. Dynamics of Mitochondrial Transport in Axons. Front Cell Neurosci. 2016; 10:123. PMID: 27242435; PMCID: PMC4865487.
      View in: PubMed, PubMed Central
    6. Shaw JL, Zhang S, Chang K. Bidirectional Regulation of Amyloid Precursor Protein-Induced Memory Defects by Nebula/DSCR1: A Protein Upregulated in Alzheimer's Disease and Down Syndrome. J Neurosci. 2015 Aug 12; 35(32):11374-83. PMID: 26269644; PMCID: PMC4532765.
      View in: PubMed, PubMed Central
    7. Chen CK, Bregere C, Paluch J, Lu JF, Dickman DK, Chang K. Activity-dependent facilitation of Synaptojanin and synaptic vesicle recycling by the Minibrain kinase. Nat Commun. 2014 Jun 30; 5:4246. PMID: 24977345; PMCID: PMC4183159.
      View in: PubMed, PubMed Central
    8. Shaw JL, Chang K. Nebula/DSCR1 upregulation delays neurodegeneration and protects against APP-induced axonal transport defects by restoring calcineurin and GSK-3ß signaling. PLoS Genet. 2013; 9(9):e1003792. PMID: 24086147; PMCID: PMC3784514.
      View in: PubMed, PubMed Central
    9. Chang K, Ro H, Wang W, Min KT. Meeting at the crossroads: common mechanisms in Fragile X and Down syndrome. Trends Neurosci. 2013 Dec; 36(12):685-94. PMID: 24075449; PMCID: PMC4090020.
      View in: PubMed, PubMed Central
    10. Niescier RF, Chang K, Min KT. Miro, MCU, and calcium: bridging our understanding of mitochondrial movement in axons. Front Cell Neurosci. 2013 Sep 10; 7:148. PMID: 24058334; PMCID: PMC3767916.
      View in: PubMed, PubMed Central
    11. Wang W, Zhu JZ, Chang K, Min KT. DSCR1 interacts with FMRP and is required for spine morphogenesis and local protein synthesis. EMBO J. 2012 Sep 12; 31(18):3655-66. PMID: 22863780; PMCID: PMC3442268.
      View in: PubMed, PubMed Central
    12. Chang K, Niescier RF, Min KT. Mitochondrial matrix Ca2+ as an intrinsic signal regulating mitochondrial motility in axons. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15456-61. PMID: 21876166; PMCID: PMC3174631.
      View in: PubMed, PubMed Central
    13. Chang K, Min KT. Progress in molecular biology and translational science. Animal models of human disease. Preface. Prog Mol Biol Transl Sci. 2011; 100:xv. PMID: 21377622.
      View in: PubMed
    14. Chang K, Min KT. Upregulation of three Drosophila homologs of human chromosome 21 genes alters synaptic function: implications for Down syndrome. Proc Natl Acad Sci U S A. 2009 Oct 06; 106(40):17117-22. PMID: 19805187; PMCID: PMC2761307.
      View in: PubMed, PubMed Central
    15. Griswold AJ, Chang K, Runko AP, Knight MA, Min KT. Sir2 mediates apoptosis through JNK-dependent pathways in Drosophila. Proc Natl Acad Sci U S A. 2008 Jun 24; 105(25):8673-8. PMID: 18562277; PMCID: PMC2438412.
      View in: PubMed, PubMed Central
    16. Chang K, Min KT. Drosophila melanogaster homolog of Down syndrome critical region 1 is critical for mitochondrial function. Nat Neurosci. 2005 Nov; 8(11):1577-85. PMID: 16222229.
      View in: PubMed
    17. Chang K, Shi YJ, Min KT. The Drosophila homolog of Down's syndrome critical region 1 gene regulates learning: implications for mental retardation. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15794-9. PMID: 14668437; PMCID: PMC307647.
      View in: PubMed, PubMed Central
    18. Hu M, Liu QS, Chang K, Berg DK. Nicotinic regulation of CREB activation in hippocampal neurons by glutamatergic and nonglutamatergic pathways. Mol Cell Neurosci. 2002 Dec; 21(4):616-25. PMID: 12504594.
      View in: PubMed
    19. Chang K, Min KT. Regulation of lifespan by histone deacetylase. Ageing Res Rev. 2002 Jun; 1(3):313-26. PMID: 12067588.
      View in: PubMed
    20. Chang K, Berg DK. Voltage-gated channels block nicotinic regulation of CREB phosphorylation and gene expression in neurons. Neuron. 2001 Dec 06; 32(5):855-65. PMID: 11738031.
      View in: PubMed
    21. Shoop RD, Chang K, Ellisman MH, Berg DK. Synaptically driven calcium transients via nicotinic receptors on somatic spines. J Neurosci. 2001 Feb 01; 21(3):771-81. PMID: 11157063.
      View in: PubMed
    22. Chang K, Berg DK. Nicotinic acetylcholine receptors containing alpha7 subunits are required for reliable synaptic transmission in situ. J Neurosci. 1999 May 15; 19(10):3701-10. PMID: 10234002.
      View in: PubMed
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