Karen Ting Chang, PhD

Title(s)Associate Professor of Physiology and Neuroscience
SchoolKeck School of Medicine of Usc
AddressZNI 219, 1501 San Pablo Street
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 1871
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    Collapse Research 
    Collapse research activities and funding
    Molecular mechanisms underlying activity-induced synaptic remodeling
    NIH R01NS102260Jul 1, 2018 - Jun 30, 2023
    Role: Principal Investigator
    Innate Immune IL-10/STAT3 Signaling in Alzheimer's Disease
    NIH RF1AG053982Sep 1, 2017 - Mar 31, 2022
    Role: Co-Principal Investigator
    (PQ#9): Altered mitochondrial transport and chemotherapy-induced peripheral neuropathy
    NIH R21CA215985Apr 1, 2017 - Mar 31, 2020
    Role: Principal Investigator
    Role of DYRK1A/MNB in synaptic growth and function
    NIH R01NS080946Jul 16, 2013 - May 31, 2023
    Role: Principal Investigator
    Peripheral TGF-beta Pathway Inhibitor Therapy in Alzheimer's Rats
    NIH R01NS076794Jun 1, 2011 - May 31, 2022
    Role: Co-Principal Investigator
    Role of nebula/DSCR1 in mitochondria
    NIH R00NS052524Sep 19, 2007 - Aug 31, 2013
    Role: Principal Investigator
    Role of nebula/DSCR1 in mitochondria
    NIH K99NS052524Sep 19, 2007 - Aug 31, 2009
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Peripheral glia and neurons jointly regulate activity-induced synaptic remodeling at the Drosophila neuromuscular junction. bioRxiv. 2024 Sep 13. Chang YC, Peng YJ, Lee JY, Chang KT. PMID: 39005352; PMCID: PMC11244886.
      View in: PubMed   Mentions:
    2. Secretory autophagy - a new paradigm regulating synaptic plasticity. Autophagy. 2024 10; 20(10):2354-2356. Chang YC, Chang KT. PMID: 38899624; PMCID: PMC11423689.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Identification of secretory autophagy as a mechanism modulating activity-induced synaptic remodeling. Proc Natl Acad Sci U S A. 2024 Apr 16; 121(16):e2315958121. Chang YC, Gao Y, Lee JY, Peng YJ, Langen J, Chang KT. PMID: 38588427; PMCID: PMC11032469.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    4. Identification of secretory autophagy as a novel mechanism modulating activity-induced synaptic remodeling. bioRxiv. 2023 Oct 06. Chang YC, Gao Y, Lee JY, Langen J, Chang KT. PMID: 38328055; PMCID: PMC10849665.
      View in: PubMed   Mentions: 3  
    5. Minibrain kinase and calcineurin coordinate activity-dependent bulk endocytosis through synaptojanin. J Cell Biol. 2021; 12(220):e202011028. Yi-Jheng Peng, Junhua Geng, Ying Wu, Cristian Pinales, Jennifer Langen, Yen-Ching Chang, Christopher Buser, Karen T Chang. .
    6. Minibrain kinase and calcineurin coordinate activity-dependent bulk endocytosis through synaptojanin. J Cell Biol. 2021 12 06; 220(12). Peng YJ, Geng J, Wu Y, Pinales C, Langen J, Chang YC, Buser C, Chang KT. PMID: 34596663; PMCID: PMC8491876.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    7. DSCR1 upregulation enhances dural meningeal lymphatic drainage to attenuate amyloid pathology of Alzheimer's disease. J Pathol. 2021 11; 255(3):296-310. Choi C, Park J, Kim H, Chang KT, Park J, Min KT. PMID: 34312845.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    8. DSCR1‐mediated TET1 splicing regulates miR‐124 expression to control adult hippocampal neurogenesis. EMBO J. 2019; 14(38):e101293. Chiyeol Choi, Taehoon Kim, Karen T Chang, Kyung-Tai Min. View Publication.
    9. Activity-Induced Synaptic Structural Modifications by an Activator of Integrin Signaling at the Drosophila Neuromuscular Junction. J Neurosci. 2017 03 22; 37(12):3246-3263. Lee JY, Geng J, Lee J, Wang AR, Chang KT. PMID: 28219985; PMCID: PMC5373117.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    10. Phosphorylation of Synaptojanin Differentially Regulates Endocytosis of Functionally Distinct Synaptic Vesicle Pools. J Neurosci. 2016 08 24; 36(34):8882-94. Geng J, Wang L, Lee JY, Chen CK, Chang KT. PMID: 27559170; PMCID: PMC4995302.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    11. Maintenance of Stem Cell Niche Integrity by a Novel Activator of Integrin Signaling. PLoS Genet. 2016 05; 12(5):e1006043. Lee JY, Chen JY, Shaw JL, Chang KT. PMID: 27191715; PMCID: PMC4871447.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    12. DSCR1 is required for both axonal growth cone extension and steering. J Cell Biol. 2016 05 23; 213(4):451-62. Wang W, Rai A, Hur EM, Smilansky Z, Chang KT, Min KT. PMID: 27185837; PMCID: PMC4878092.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    13. Dynamics of Mitochondrial Transport in Axons. Front Cell Neurosci. 2016; 10:123. Niescier RF, Kwak SK, Joo SH, Chang KT, Min KT. PMID: 27242435; PMCID: PMC4865487.
      View in: PubMed   Mentions: 17  
    14. Bidirectional Regulation of Amyloid Precursor Protein-Induced Memory Defects by Nebula/DSCR1: A Protein Upregulated in Alzheimer's Disease and Down Syndrome. J Neurosci. 2015 Aug 12; 35(32):11374-83. Shaw JL, Zhang S, Chang KT. PMID: 26269644; PMCID: PMC4532765.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    15. Activity-dependent facilitation of Synaptojanin and synaptic vesicle recycling by the Minibrain kinase. Nat Commun. 2014 Jun 30; 5:4246. Chen CK, Bregere C, Paluch J, Lu JF, Dickman DK, Chang KT. PMID: 24977345; PMCID: PMC4183159.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    16. Nebula/DSCR1 upregulation delays neurodegeneration and protects against APP-induced axonal transport defects by restoring calcineurin and GSK-3β signaling. PLoS Genet. 2013; 9(9):e1003792. Shaw JL, Chang KT. PMID: 24086147; PMCID: PMC3784514.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    17. Meeting at the crossroads: common mechanisms in Fragile X and Down syndrome. Trends Neurosci. 2013 Dec; 36(12):685-94. Chang KT, Ro H, Wang W, Min KT. PMID: 24075449; PMCID: PMC4090020.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    18. Miro, MCU, and calcium: bridging our understanding of mitochondrial movement in axons. Front Cell Neurosci. 2013 Sep 10; 7:148. Niescier RF, Chang KT, Min KT. PMID: 24058334; PMCID: PMC3767916.
      View in: PubMed   Mentions: 12  
    19. DSCR1 interacts with FMRP and is required for spine morphogenesis and local protein synthesis. EMBO J. 2012 Sep 12; 31(18):3655-66. Wang W, Zhu JZ, Chang KT, Min KT. PMID: 22863780; PMCID: PMC3442268.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    20. Mitochondrial matrix Ca2+ as an intrinsic signal regulating mitochondrial motility in axons. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15456-61. Chang KT, Niescier RF, Min KT. PMID: 21876166; PMCID: PMC3174631.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    21. Progress in molecular biology and translational science. Animal models of human disease. Preface. Prog Mol Biol Transl Sci. 2011; 100:xv. Chang KT, Min KT. PMID: 21377622.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    22. Upregulation of three Drosophila homologs of human chromosome 21 genes alters synaptic function: implications for Down syndrome. Proc Natl Acad Sci U S A. 2009 Oct 06; 106(40):17117-22. Chang KT, Min KT. PMID: 19805187; PMCID: PMC2761307.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    23. Sir2 mediates apoptosis through JNK-dependent pathways in Drosophila. Proc Natl Acad Sci U S A. 2008 Jun 24; 105(25):8673-8. Griswold AJ, Chang KT, Runko AP, Knight MA, Min KT. PMID: 18562277; PMCID: PMC2438412.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    24. Drosophila melanogaster homolog of Down syndrome critical region 1 is critical for mitochondrial function. Nat Neurosci. 2005 Nov; 8(11):1577-85. Chang KT, Min KT. PMID: 16222229.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    25. The Drosophila homolog of Down's syndrome critical region 1 gene regulates learning: implications for mental retardation. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15794-9. Chang KT, Shi YJ, Min KT. PMID: 14668437; PMCID: PMC307647.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    26. Nicotinic regulation of CREB activation in hippocampal neurons by glutamatergic and nonglutamatergic pathways. Mol Cell Neurosci. 2002 Dec; 21(4):616-25. Hu M, Liu QS, Chang KT, Berg DK. PMID: 12504594.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    27. Regulation of lifespan by histone deacetylase. Ageing Res Rev. 2002 Jun; 1(3):313-26. Chang KT, Min KT. PMID: 12067588.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    28. Voltage-gated channels block nicotinic regulation of CREB phosphorylation and gene expression in neurons. Neuron. 2001 Dec 06; 32(5):855-65. Chang KT, Berg DK. PMID: 11738031.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    29. Synaptically driven calcium transients via nicotinic receptors on somatic spines. J Neurosci. 2001 Feb 01; 21(3):771-81. Shoop RD, Chang KT, Ellisman MH, Berg DK. PMID: 11157063; PMCID: PMC6762332.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    30. Nicotinic acetylcholine receptors containing alpha7 subunits are required for reliable synaptic transmission in situ. J Neurosci. 1999 May 15; 19(10):3701-10. Chang KT, Berg DK. PMID: 10234002; PMCID: PMC6782692.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
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    NIH Funding Acknowledgment: Important - All publications resulting from the utilization of SC CTSI resources are required to credit the SC CTSI grant by including the NIH funding acknowledgment and must comply with the NIH Public Access Policy.

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