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Karen Ting Chang, PhD

Title(s)Associate Professor of Physiology and Neuroscience
SchoolKeck School of Medicine of USC
Phone+1 323 442 1871
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    Collapse Research 
    Collapse Research Activities and Funding
    Molecular mechanisms underlying activity-induced synaptic remodeling
    NIH/NINDS R01NS102260Jul 1, 2018 - Jun 30, 2023
    Role: Principal Investigator
    (PQ#9): Altered mitochondrial transport and chemotherapy-induced peripheral neuropathy
    NIH/NCI R21CA215985Apr 1, 2017 - Mar 31, 2019
    Role: Principal Investigator
    Role of DYRK1A/MNB in Synaptic growth and function
    NIH/NINDS R01NS080946Jul 16, 2013 - May 31, 2023
    Role: Principal Investigator
    Role of nebula/DSCR1 in mitochondria
    NIH/NINDS R00NS052524Sep 19, 2007 - Aug 31, 2013
    Role: Principal Investigator
    Role of nebula/DSCR1 in mitochondria
    NIH/NINDS K99NS052524Sep 19, 2007 - Aug 31, 2009
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Chang KT, Mukanu M, Bellows B, Hameed W, Kalamar AM, Grépin KA, Gul X, Chakraborty NM. Evaluating Quality of Contraceptive Counseling: An analysis of the Method Information Index. Stud Fam Plann. 2019 Jan 21. PMID: 30666641.
      View in: PubMed
    2. Chang KT, Mullany LC, Khatry SK, LeClerq SC, Munos MK, Katz J. Why some mothers overestimate birth size and length of pregnancy in rural Nepal. J Glob Health. 2018 Dec; 8(2):020801. PMID: 30206478.
      View in: PubMed
    3. Chang KT, Mullany LC, Khatry SK, LeClerq SC, Munos MK, Katz J. Validation of maternal reports for low birthweight and preterm birth indicators in rural Nepal. J Glob Health. 2018 Jun; 8(1):010604. PMID: 29899981.
      View in: PubMed
    4. Lee JY, Geng J, Lee J, Wang AR, Chang KT. Activity-Induced Synaptic Structural Modifications by an Activator of Integrin Signaling at the Drosophila Neuromuscular Junction. J Neurosci. 2017 03 22; 37(12):3246-3263. PMID: 28219985.
      View in: PubMed
    5. Geng J, Wang L, Lee JY, Chen CK, Chang KT. Phosphorylation of Synaptojanin Differentially Regulates Endocytosis of Functionally Distinct Synaptic Vesicle Pools. J Neurosci. 2016 08 24; 36(34):8882-94. PMID: 27559170; PMCID: PMC4995302 [Available on 02/24/17].
    6. Lee JY, Chen JY, Shaw JL, Chang KT. Maintenance of Stem Cell Niche Integrity by a Novel Activator of Integrin Signaling. PLoS Genet. 2016 05; 12(5):e1006043. PMID: 27191715.
      View in: PubMed
    7. Wang W, Rai A, Hur EM, Smilansky Z, Chang KT, Min KT. DSCR1 is required for both axonal growth cone extension and steering. J Cell Biol. 2016 05 23; 213(4):451-62. PMID: 27185837.
      View in: PubMed
    8. Niescier RF, Kwak SK, Joo SH, Chang KT, Min KT. Dynamics of Mitochondrial Transport in Axons. Front Cell Neurosci. 2016; 10:123. PMID: 27242435; PMCID: PMC4865487.
    9. Shaw JL, Zhang S, Chang KT. Bidirectional Regulation of Amyloid Precursor Protein-Induced Memory Defects by Nebula/DSCR1: A Protein Upregulated in Alzheimer's Disease and Down Syndrome. J Neurosci. 2015 Aug 12; 35(32):11374-83. PMID: 26269644; PMCID: PMC4532765.
    10. Chen CK, Bregere C, Paluch J, Lu JF, Dickman DK, Chang KT. Activity-dependent facilitation of Synaptojanin and synaptic vesicle recycling by the Minibrain kinase. Nat Commun. 2014 Jun 30; 5:4246. PMID: 24977345; PMCID: PMC4183159.
    11. Shaw JL, Chang KT. Nebula/DSCR1 upregulation delays neurodegeneration and protects against APP-induced axonal transport defects by restoring calcineurin and GSK-3ß signaling. PLoS Genet. 2013; 9(9):e1003792. PMID: 24086147; PMCID: PMC3784514.
    12. Chang KT, Ro H, Wang W, Min KT. Meeting at the crossroads: common mechanisms in Fragile X and Down syndrome. Trends Neurosci. 2013 Dec; 36(12):685-94. PMID: 24075449; PMCID: PMC4090020.
    13. Niescier RF, Chang KT, Min KT. Miro, MCU, and calcium: bridging our understanding of mitochondrial movement in axons. Front Cell Neurosci. 2013 Sep 10; 7:148. PMID: 24058334; PMCID: PMC3767916.
    14. Wang W, Zhu JZ, Chang KT, Min KT. DSCR1 interacts with FMRP and is required for spine morphogenesis and local protein synthesis. EMBO J. 2012 Sep 12; 31(18):3655-66. PMID: 22863780; PMCID: PMC3442268.
    15. Chang KT, Niescier RF, Min KT. Mitochondrial matrix Ca2+ as an intrinsic signal regulating mitochondrial motility in axons. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15456-61. PMID: 21876166; PMCID: PMC3174631.
    16. Chang KT, Min KT. Progress in molecular biology and translational science. Animal models of human disease. Preface. Prog Mol Biol Transl Sci. 2011; 100:xv. PMID: 21377622.
      View in: PubMed
    17. Chang KT, Min KT. Upregulation of three Drosophila homologs of human chromosome 21 genes alters synaptic function: implications for Down syndrome. Proc Natl Acad Sci U S A. 2009 Oct 06; 106(40):17117-22. PMID: 19805187; PMCID: PMC2761307.
    18. Griswold AJ, Chang KT, Runko AP, Knight MA, Min KT. Sir2 mediates apoptosis through JNK-dependent pathways in Drosophila. Proc Natl Acad Sci U S A. 2008 Jun 24; 105(25):8673-8. PMID: 18562277; PMCID: PMC2438412.
    19. Chang KT, Min KT. Drosophila melanogaster homolog of Down syndrome critical region 1 is critical for mitochondrial function. Nat Neurosci. 2005 Nov; 8(11):1577-85. PMID: 16222229.
      View in: PubMed
    20. Chang KT, Shi YJ, Min KT. The Drosophila homolog of Down's syndrome critical region 1 gene regulates learning: implications for mental retardation. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15794-9. PMID: 14668437; PMCID: PMC307647.
    21. Hu M, Liu QS, Chang KT, Berg DK. Nicotinic regulation of CREB activation in hippocampal neurons by glutamatergic and nonglutamatergic pathways. Mol Cell Neurosci. 2002 Dec; 21(4):616-25. PMID: 12504594.
      View in: PubMed
    22. Chang KT, Min KT. Regulation of lifespan by histone deacetylase. Ageing Res Rev. 2002 Jun; 1(3):313-26. PMID: 12067588.
      View in: PubMed
    23. Chang KT, Berg DK. Voltage-gated channels block nicotinic regulation of CREB phosphorylation and gene expression in neurons. Neuron. 2001 Dec 06; 32(5):855-65. PMID: 11738031.
      View in: PubMed
    24. Shoop RD, Chang KT, Ellisman MH, Berg DK. Synaptically driven calcium transients via nicotinic receptors on somatic spines. J Neurosci. 2001 Feb 01; 21(3):771-81. PMID: 11157063.
      View in: PubMed
    25. Chang KT, Berg DK. Nicotinic acetylcholine receptors containing alpha7 subunits are required for reliable synaptic transmission in situ. J Neurosci. 1999 May 15; 19(10):3701-10. PMID: 10234002.
      View in: PubMed