Anisa Shaker, MD

Title(s)Associate Professor of Medicine
SchoolKeck School of Medicine of Usc
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    Other Positions
    Title(s)Director of the Swallowing and Esophageal Disorders Center

    Collapse Biography 
    Collapse Awards and Honors
    Association of American Medical Colleges2011Early Career Women Faculty Professional Development Seminar
    American Gastroenterology Association2015Women's Leadership Conference

    Collapse Overview 
    Collapse Overview
    Dr. Shaker is a physician-scientist with a clinical and research interest in esophageal disorders. Her research program is focused on understanding the mechanisms of esophageal injury, repair, and inflammation. Her work is supported by both federal and private funding. Dr. Shaker has authored several articles in peer-reviewed journals and serves as a mentor to physicians in training interested in gastrointestinal research.

    Dr. Shaker earned her medical degree from Medical College of Wisconsin. She then performed her internship and residency at Brown University- Rhode Island Hospital, followed by a Gastroenterology Fellowship at Washington University School of Medicine- Barnes Jewish Hospital.

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    Collapse Research 
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    The role of esophageal myofibroblasts in alcohol related esophageal squamous cell carcinoma.
    NIH R21AA028891Mar 15, 2021 - Feb 28, 2023
    Role: Principal Investigator
    The role of human esophageal myofibroblasts in regulating the epithelial response in GERD
    NIH R01DK118065Sep 12, 2019 - May 31, 2024
    Role: Principal Investigator
    Epithelial-stromal cross-talk in esophageal inflammation and carcinogenesis.
    NIH R03CA198692Aug 1, 2015 - Jul 31, 2018
    Role: Principal Investigator
    NIH K08CA153036Jul 1, 2011 - Jan 31, 2018
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The Travels of Signet-Ring Cell Carcinoma: From Colon to Stomach and Duodenum. ACG Case Rep J. 2023 Dec; 10(12):e01239. Tom CK, Placone N, Yung E, Shaker A. PMID: 38130481; PMCID: PMC10735161.
      View in: PubMed   Mentions:
    2. Direct and indirect effects of alcohol and its toxic metabolite acetaldehyde on human esophageal myofibroblasts and epithelial cells. Alcohol Clin Exp Res (Hoboken). 2023 Jul; 47(7):1297-1311. Khalatbari A, Castle JD, Li T, Shaker A. PMID: 37128647; PMCID: PMC10524176.
      View in: PubMed   Mentions:
    3. Inflammatory and Proliferative Pathway Activation in Human Esophageal Myofibroblasts Treated with Acidic Bile Salts. Int J Mol Sci. 2022 Sep 08; 23(18). Patankar M, Li M, Khalatbari A, Castle JD, Hu L, Zhang C, Shaker A. PMID: 36142285; PMCID: PMC9498994.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    4. Pattern of methane levels with lactulose breath testing; can we shorten the test duration? JGH Open. 2021 Jul; 5(7):809-812. Shaker A, Peng B, Soffer E. PMID: 34263076; PMCID: PMC8264240.
      View in: PubMed   Mentions:
    5. Is Avoiding Stem Cell Exhaustion the New Therapeutic Approach in Colitis? Cell Mol Gastroenterol Hepatol. 2021; 11(4):1204-1206. Shaker A. PMID: 33373602; PMCID: PMC8053613.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    6. Human esophageal myofibroblasts increase squamous epithelial thickness via paracrine mechanisms in an in vitro model of gastroesophageal reflux disease. PLoS One. 2020; 15(9):e0238852. Hu L, Zhang C, Yang K, Li M, Shaker A. PMID: 32925965; PMCID: PMC7489504.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    7. Gender-Specific Risk Factors for Reflux Esophagitis in a Predominantly Hispanic Population of a Large Safety-Net Hospital. Dig Dis Sci. 2021 06; 66(6):1940-1948. Haghighat S, Park C, Horwich B, Liu Y, Soffer E, Idos G, Shaker A. PMID: 32691385; PMCID: PMC8163663.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Human esophageal myofibroblast secretion of bone morphogenetic proteins and GREMLIN1 and paracrine regulation of squamous epithelial growth. Sci Rep. 2018 08 17; 8(1):12354. Zhang C, Niu C, Yang K, Shaker A. PMID: 30120338; PMCID: PMC6098060.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    9. Provocative testing of the esophagus and its future. Ann N Y Acad Sci. 2016 09; 1380(1):33-47. Farmer AD, Franchina M, Gregersen H, Penagini R, Shaker A, Soffer E. PMID: 27311061.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. Generation and Characterization of an Immortalized Human Esophageal Myofibroblast Line. PLoS One. 2016; 11(4):e0153185. Niu C, Chauhan U, Gargus M, Shaker A. PMID: 27055018; PMCID: PMC4824353.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    11. Human esophageal myofibroblasts secrete proinflammatory cytokines in response to acid and Toll-like receptor 4 ligands. Am J Physiol Gastrointest Liver Physiol. 2015 Jun 01; 308(11):G904-23. Gargus M, Niu C, Vallone JG, Binkley J, Rubin DC, Shaker A. PMID: 25882613; PMCID: PMC4451324.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    12. Isolation of myofibroblasts from mouse and human esophagus. J Vis Exp. 2015 Jan 18; (95):52215. Gargus M, Niu C, Shaker A. PMID: 25650889; PMCID: PMC4354535.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    13. Epimorphin(-/-) mice are protected, in part, from acute colitis via decreased interleukin 6 signaling. Transl Res. 2014 Jul; 164(1):70-83. Shaker A, Gargus M, Fink J, Binkley J, Darwech I, Swietlicki E, Levin MS, Rubin DC. PMID: 24731292; PMCID: PMC4278761.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    14. Multiple rapid swallow responses during esophageal high-resolution manometry reflect esophageal body peristaltic reserve. Am J Gastroenterol. 2013 Nov; 108(11):1706-12. Shaker A, Stoikes N, Drapekin J, Kushnir V, Brunt LM, Gyawali CP. PMID: 24019081; PMCID: PMC4091619.
      View in: PubMed   Mentions: 85     Fields:    Translation:Humans
    15. Epimorphin deletion inhibits polyposis in the Apcmin/+ mouse model of colon carcinogenesis via decreased myofibroblast HGF secretion. Am J Physiol Gastrointest Liver Physiol. 2013 Oct 15; 305(8):G564-72. Swietlicki EA, Bala S, Lu J, Shaker A, Kularatna G, Levin MS, Rubin DC. PMID: 23886856; PMCID: PMC3798733.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    16. Stromal cells participate in the murine esophageal mucosal injury response. Am J Physiol Gastrointest Liver Physiol. 2013 Apr 01; 304(7):G662-72. Shaker A, Binkley J, Darwech I, Swietlicki E, McDonald K, Newberry R, Rubin DC. PMID: 23370675; PMCID: PMC3625876.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    17. Modeling colitis-associated cancer with azoxymethane (AOM) and dextran sulfate sodium (DSS). J Vis Exp. 2012 Sep 11; (67). Thaker AI, Shaker A, Rao MS, Ciorba MA. PMID: 22990604; PMCID: PMC3490277.
      View in: PubMed   Mentions: 85     Fields:    Translation:Animals
    18. The value of multiple rapid swallows during preoperative esophageal manometry before laparoscopic antireflux surgery. Surg Endosc. 2012 Dec; 26(12):3401-7. Stoikes N, Drapekin J, Kushnir V, Shaker A, Brunt LM, Gyawali CP. PMID: 22648115; PMCID: PMC4098863.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    19. Stem cells: One step closer to gut repair. Nature. 2012 May 09; 485(7397):181-2. Shaker A, Rubin DC. PMID: 22575955; PMCID: PMC4034543.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    20. Chronic intestinal inflammation: inflammatory bowel disease and colitis-associated colon cancer. Front Immunol. 2012; 3:107. Rubin DC, Shaker A, Levin MS. PMID: 22586430; PMCID: PMC3347037.
      View in: PubMed   Mentions: 173     Fields:    
    21. Intestinal stem cells and epithelial-mesenchymal interactions in the crypt and stem cell niche. Transl Res. 2010 Sep; 156(3):180-7. Shaker A, Rubin DC. PMID: 20801415; PMCID: PMC3019104.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    22. Epimorphin deletion protects mice from inflammation-induced colon carcinogenesis and alters stem cell niche myofibroblast secretion. J Clin Invest. 2010 Jun; 120(6):2081-93. Shaker A, Swietlicki EA, Wang L, Jiang S, Onal B, Bala S, DeSchryver K, Newberry R, Levin MS, Rubin DC. PMID: 20458144; PMCID: PMC2877942.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    23. Miriam Hospital morbidity and mortality conference, a case of chronic headaches. Med Health R I. 2004 Sep; 87(9):280-3. Shaker A, Snyder JE. PMID: 15503887.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
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