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Anisa Shaker, MD

Title(s)Assistant Professor of Medicine
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    Collapse Biography 
    Collapse Awards and Honors
    Association of American Medical Colleges2011Early Career Women Faculty Professional Development Seminar
    American Gastroenterology Association2015Women's Leadership Conference

    Collapse Overview 
    Collapse Overview
    Dr. Shaker is a physician-scientist with a clinical and research interest in esophageal disorders. Her research program is focused on understanding the mechanisms of esophageal injury, repair, and inflammation. Her work is supported by both federal and private funding. Dr. Shaker has authored several articles in peer-reviewed journals and serves as a mentor to physicians in training interested in gastrointestinal research.

    Dr. Shaker earned her medical degree from Medical College of Wisconsin. She then performed her internship and residency at Brown University- Rhode Island Hospital, followed by a Gastroenterology Fellowship at Washington University School of Medicine- Barnes Jewish Hospital.

    Collapse Research 
    Collapse Research Activities and Funding
    The role of human esophageal myofibroblasts in regulating the epithelial response in GERD
    NIH/NIDDK R01DK118065Sep 12, 2019 - May 31, 2024
    Role: Principal Investigator
    Epithelial-stromal cross-talk in esophageal inflammation and carcinogenesis.
    NIH/NCI R03CA198692Aug 1, 2015 - Jul 31, 2017
    Role: Principal Investigator
    EPIMORPHIN DELETION ALTERS STEM CELL NICHE MYOFIBROBLAST SECRETION
    NIH/NCI K08CA153036Jul 1, 2011 - Jan 31, 2017
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Required Scholarly Project Mentor

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Zhang C, Niu C, Yang K, Shaker A. Human esophageal myofibroblast secretion of bone morphogenetic proteins and GREMLIN1 and paracrine regulation of squamous epithelial growth. Sci Rep. 2018 08 17; 8(1):12354. PMID: 30120338.
      View in: PubMed
    2. Farmer AD, Franchina M, Gregersen H, Penagini R, Shaker A, Soffer E. Provocative testing of the esophagus and its future. Ann N Y Acad Sci. 2016 09; 1380(1):33-47. PMID: 27311061.
      View in: PubMed
    3. Niu C, Chauhan U, Gargus M, Shaker A. Generation and Characterization of an Immortalized Human Esophageal Myofibroblast Line. PLoS One. 2016; 11(4):e0153185. PMID: 27055018.
      View in: PubMed
    4. Gargus M, Niu C, Vallone JG, Binkley J, Rubin DC, Shaker A. Human esophageal myofibroblasts secrete proinflammatory cytokines in response to acid and Toll-like receptor 4 ligands. Am J Physiol Gastrointest Liver Physiol. 2015 Jun 01; 308(11):G904-23. PMID: 25882613.
      View in: PubMed
    5. Gargus M, Niu C, Shaker A. Isolation of myofibroblasts from mouse and human esophagus. J Vis Exp. 2015 Jan 18; (95):52215. PMID: 25650889.
      View in: PubMed
    6. Shaker A, Gargus M, Fink J, Binkley J, Darwech I, Swietlicki E, Levin MS, Rubin DC. Epimorphin(-/-) mice are protected, in part, from acute colitis via decreased interleukin 6 signaling. Transl Res. 2014 Jul; 164(1):70-83. PMID: 24731292.
      View in: PubMed
    7. Shaker A, Stoikes N, Drapekin J, Kushnir V, Brunt LM, Gyawali CP. Multiple rapid swallow responses during esophageal high-resolution manometry reflect esophageal body peristaltic reserve. Am J Gastroenterol. 2013 Nov; 108(11):1706-12. PMID: 24019081.
      View in: PubMed
    8. Swietlicki EA, Bala S, Lu J, Shaker A, Kularatna G, Levin MS, Rubin DC. Epimorphin deletion inhibits polyposis in the Apcmin/+ mouse model of colon carcinogenesis via decreased myofibroblast HGF secretion. Am J Physiol Gastrointest Liver Physiol. 2013 Oct 15; 305(8):G564-72. PMID: 23886856.
      View in: PubMed
    9. Shaker A, Binkley J, Darwech I, Swietlicki E, McDonald K, Newberry R, Rubin DC. Stromal cells participate in the murine esophageal mucosal injury response. Am J Physiol Gastrointest Liver Physiol. 2013 Apr 01; 304(7):G662-72. PMID: 23370675.
      View in: PubMed
    10. Thaker AI, Shaker A, Rao MS, Ciorba MA. Modeling colitis-associated cancer with azoxymethane (AOM) and dextran sulfate sodium (DSS). J Vis Exp. 2012 Sep 11; (67). PMID: 22990604.
      View in: PubMed
    11. Stoikes N, Drapekin J, Kushnir V, Shaker A, Brunt LM, Gyawali CP. The value of multiple rapid swallows during preoperative esophageal manometry before laparoscopic antireflux surgery. Surg Endosc. 2012 Dec; 26(12):3401-7. PMID: 22648115.
      View in: PubMed
    12. Shaker A, Rubin DC. Stem cells: One step closer to gut repair. Nature. 2012 May 09; 485(7397):181-2. PMID: 22575955.
      View in: PubMed
    13. Rubin DC, Shaker A, Levin MS. Chronic intestinal inflammation: inflammatory bowel disease and colitis-associated colon cancer. Front Immunol. 2012; 3:107. PMID: 22586430.
      View in: PubMed
    14. Shaker A, Rubin DC. Intestinal stem cells and epithelial-mesenchymal interactions in the crypt and stem cell niche. Transl Res. 2010 Sep; 156(3):180-7. PMID: 20801415.
      View in: PubMed
    15. Shaker A, Swietlicki EA, Wang L, Jiang S, Onal B, Bala S, DeSchryver K, Newberry R, Levin MS, Rubin DC. Epimorphin deletion protects mice from inflammation-induced colon carcinogenesis and alters stem cell niche myofibroblast secretion. J Clin Invest. 2010 Jun; 120(6):2081-93. PMID: 20458144.
      View in: PubMed
    16. Shaker A, Snyder JE. Miriam Hospital morbidity and mortality conference, a case of chronic headaches. Med Health R I. 2004 Sep; 87(9):280-3. PMID: 15503887.
      View in: PubMed
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