Anisa Shaker, MD

Title(s)Assistant Professor of Medicine
AddressHMR 810
Health Sciences Campus
Los Angeles CA 90089-9091
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    Collapse Biography 
    Collapse Awards and Honors
    Association of American Medical Colleges2011Early Career Women Faculty Professional Development Seminar
    American Gastroenterology Association2015Women's Leadership Conference

    Collapse Overview 
    Collapse Overview
    Dr. Shaker is a physician-scientist with a clinical and research interest in esophageal disorders. Her research program is focused on understanding the mechanisms of esophageal injury, repair, and inflammation. Her work is supported by both federal and private funding. Dr. Shaker has authored several articles in peer-reviewed journals and serves as a mentor to physicians in training interested in gastrointestinal research.

    Dr. Shaker earned her medical degree from Medical College of Wisconsin. She then performed her internship and residency at Brown University- Rhode Island Hospital, followed by a Gastroenterology Fellowship at Washington University School of Medicine- Barnes Jewish Hospital.

    Lab site: https://sites.usc.edu/shakerlab/

    Collapse Research 
    Collapse Research Activities and Funding
    The role of human esophageal myofibroblasts in regulating the epithelial response in GERD
    NIH/NIDDK R01DK118065Sep 12, 2019 - May 31, 2024
    Role: Principal Investigator
    Epithelial-stromal cross-talk in esophageal inflammation and carcinogenesis.
    NIH/NCI R03CA198692Aug 1, 2015 - Jul 31, 2017
    Role: Principal Investigator
    NIH/NCI K08CA153036Jul 1, 2011 - Jun 30, 2016
    Role: Principal Investigator

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    Collapse Required Scholarly Project Mentor

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Gender-Specific Risk Factors for Reflux Esophagitis in a Predominantly Hispanic Population of a Large Safety-Net Hospital. Dig Dis Sci. 2020 Jul 20. Haghighat S, Park C, Horwich B, Liu Y, Soffer E, Idos G, Shaker A. PMID: 32691385.
      View in: PubMed   Mentions:    Fields:    
    2. Human esophageal myofibroblast secretion of bone morphogenetic proteins and GREMLIN1 and paracrine regulation of squamous epithelial growth. Sci Rep. 2018 08 17; 8(1):12354. Zhang C, Niu C, Yang K, Shaker A. PMID: 30120338.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    3. Provocative testing of the esophagus and its future. Ann N Y Acad Sci. 2016 09; 1380(1):33-47. Farmer AD, Franchina M, Gregersen H, Penagini R, Shaker A, Soffer E. PMID: 27311061.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    4. Generation and Characterization of an Immortalized Human Esophageal Myofibroblast Line. PLoS One. 2016; 11(4):e0153185. Niu C, Chauhan U, Gargus M, Shaker A. PMID: 27055018.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    5. Human esophageal myofibroblasts secrete proinflammatory cytokines in response to acid and Toll-like receptor 4 ligands. Am J Physiol Gastrointest Liver Physiol. 2015 Jun 01; 308(11):G904-23. Gargus M, Niu C, Vallone JG, Binkley J, Rubin DC, Shaker A. PMID: 25882613.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    6. Isolation of myofibroblasts from mouse and human esophagus. J Vis Exp. 2015 Jan 18; (95):52215. Gargus M, Niu C, Shaker A. PMID: 25650889.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    7. Epimorphin(-/-) mice are protected, in part, from acute colitis via decreased interleukin 6 signaling. Transl Res. 2014 Jul; 164(1):70-83. Shaker A, Gargus M, Fink J, Binkley J, Darwech I, Swietlicki E, Levin MS, Rubin DC. PMID: 24731292.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    8. Multiple rapid swallow responses during esophageal high-resolution manometry reflect esophageal body peristaltic reserve. Am J Gastroenterol. 2013 Nov; 108(11):1706-12. Shaker A, Stoikes N, Drapekin J, Kushnir V, Brunt LM, Gyawali CP. PMID: 24019081.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    9. Epimorphin deletion inhibits polyposis in the Apcmin/+ mouse model of colon carcinogenesis via decreased myofibroblast HGF secretion. Am J Physiol Gastrointest Liver Physiol. 2013 Oct 15; 305(8):G564-72. Swietlicki EA, Bala S, Lu J, Shaker A, Kularatna G, Levin MS, Rubin DC. PMID: 23886856.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    10. Stromal cells participate in the murine esophageal mucosal injury response. Am J Physiol Gastrointest Liver Physiol. 2013 Apr 01; 304(7):G662-72. Shaker A, Binkley J, Darwech I, Swietlicki E, McDonald K, Newberry R, Rubin DC. PMID: 23370675.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    11. Modeling colitis-associated cancer with azoxymethane (AOM) and dextran sulfate sodium (DSS). J Vis Exp. 2012 Sep 11; (67). Thaker AI, Shaker A, Rao MS, Ciorba MA. PMID: 22990604.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    12. The value of multiple rapid swallows during preoperative esophageal manometry before laparoscopic antireflux surgery. Surg Endosc. 2012 Dec; 26(12):3401-7. Stoikes N, Drapekin J, Kushnir V, Shaker A, Brunt LM, Gyawali CP. PMID: 22648115.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    13. Stem cells: One step closer to gut repair. Nature. 2012 May 09; 485(7397):181-2. Shaker A, Rubin DC. PMID: 22575955.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    14. Chronic intestinal inflammation: inflammatory bowel disease and colitis-associated colon cancer. Front Immunol. 2012; 3:107. Rubin DC, Shaker A, Levin MS. PMID: 22586430.
      View in: PubMed   Mentions: 90     Fields:    
    15. Intestinal stem cells and epithelial-mesenchymal interactions in the crypt and stem cell niche. Transl Res. 2010 Sep; 156(3):180-7. Shaker A, Rubin DC. PMID: 20801415.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    16. Epimorphin deletion protects mice from inflammation-induced colon carcinogenesis and alters stem cell niche myofibroblast secretion. J Clin Invest. 2010 Jun; 120(6):2081-93. Shaker A, Swietlicki EA, Wang L, Jiang S, Onal B, Bala S, DeSchryver K, Newberry R, Levin MS, Rubin DC. PMID: 20458144.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    17. Miriam Hospital morbidity and mortality conference, a case of chronic headaches. Med Health R I. 2004 Sep; 87(9):280-3. Shaker A, Snyder JE. PMID: 15503887.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
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