Loading...

Zorica Buser, PhD

TitleAssistant Professor of Research Orthopaedic Surgery
InstitutionUniversity of Southern California
DepartmentOrthopaedic Surgery
Address1450 Biggy Street, NRT-2509N
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 0206
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    University of Belgrade , SerbiaBachelor of Science2002Molecular Biology & Physiology
    University of California, San Francisco , San Francisco, CAPostdoctoral Fellow2011Orthopaedics
    Institute of Orthopaedic Research & Biomechanics, University of Ulm, GermanyPostdoctoral Fellow2007Orthopaedic Research & Biomechanics
    Department of Human Genetics, University of Ulm, GermanyPh.D.2005Human Genetics

    Collapse Overview 
    Collapse Overview
    The Spine laboratory studies the biology and mechanisms of various spine pathologies using basic science models and clinical research. Our projects cover in vitro and in vivo research on vertebral fusion, bone formation, and intervertebral discs. Our clinical studies utilize a multidisciplinary approach to investigate the causation of degenerative spinal conditions and their current treatments, including outcomes and cost. We are also investigating new diagnostic and treatment approaches in tissue engineering, biomarkers and mechanobiology, and the potential of progenitor and stem cells to drive disc regeneration. On the cellular level we are interested in the changes within mitochondria, the cell’s power plants, during disc degeneration.


    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Sessumpun K, Paholpak P, Hindoyan KN, Tamai K, Sangkomkamhang T, Buser Z, Wang JC. Characteristics of Cervical Spine Motion in Different Types of Cervical Alignment: Kinematic MRI Study. Clin Spine Surg. 2018 May; 31(4):E239-E244. PMID: 29315118.
      View in: PubMed
    2. Hegde V, Arshi A, Wang C, Buser Z, Wang JC, Jensen AR, Adams JS, Zeegen EN, Bernthal NM. Preoperative Vitamin D Deficiency Is Associated With Higher Postoperative Complication Rates in Total Knee Arthroplasty. Orthopedics. 2018 Apr 27; 1-7. PMID: 29708568.
      View in: PubMed
    3. Morishita Y, Buser Z, D'Oro A, Shiba K, Wang JC. Clinical Relationship of Degenerative Changes between the Cervical and Lumbar Spine. Asian Spine J. 2018 Apr; 12(2):343-348. PMID: 29713417.
      View in: PubMed
    4. Arshi A, Leong NL, Wang C, Buser Z, Wang JC, Vezeridis PS, McAllister DR, Petrigliano FA. Relative Complications and Trends of Outpatient Total Shoulder Arthroplasty. Orthopedics. 2018 May 01; 41(3):e400-e409. PMID: 29658980.
      View in: PubMed
    5. Arshi A, Park HY, Blumstein GW, Wang C, Buser Z, Wang JC, Shamie AN, Park DY. Outpatient Posterior Lumbar Fusion: A Population-Based Analysis of Trends and Complication Rates. Spine (Phila Pa 1976). 2018 Apr 10. PMID: 29642137.
      View in: PubMed
    6. Tamai K, Buser Z, Paholpak P, Sessumpun K, Nakamura H, Wang JC. Can C7 Slope Substitute the T1 slope?: An Analysis Using Cervical Radiographs and Kinematic MRIs. Spine (Phila Pa 1976). 2018 04 01; 43(7):520-525. PMID: 28767624.
      View in: PubMed
    7. Tamai K, Chen J, Stone M, Arakelyan A, Paholpak P, Nakamura H, Buser Z, Wang JC. The evaluation of lumbar paraspinal muscle quantity and quality using the Goutallier classification and lumbar indentation value. Eur Spine J. 2018 Feb 02. PMID: 29396765.
      View in: PubMed
    8. Tamai K, Romanu J, Grisdela P, Paholpak P, Zheng P, Nakamura H, Buser Z, Wang JC. Small C7-T1 lordotic angle and muscle degeneration at C7 level were independent radiological characteristics of patients with cervical imbalance: a propensity score-matched analysis. Spine J. 2018 Jan 31. PMID: 29355790.
      View in: PubMed
    9. Devana SK, Jensen AR, Yamaguchi KT, D'Oro A, Buser Z, Wang JC, Petrigliano FA, Dowd C. Trends and Complications in Open Versus Endoscopic Carpal Tunnel Release in Private Payer and Medicare Patient Populations. Hand (N Y). 2018 Jan 01; 1558944717751196. PMID: 29322873.
      View in: PubMed
    10. Arshi A, Leong NL, D'Oro A, Wang C, Buser Z, Wang JC, Jones KJ, Petrigliano FA, SooHoo NF. Outpatient Total Knee Arthroplasty Is Associated with Higher Risk of Perioperative Complications. J Bone Joint Surg Am. 2017 Dec 06; 99(23):1978-1986. PMID: 29206787.
      View in: PubMed
    11. Ajiboye RM, Park HY, Cohen JR, Vellios EE, Lord EL, Ashana AO, Buser Z, Wang JC. Demographic Trends in the Use of Intraoperative Neuromonitoring for Scoliosis Surgery in the United States. Int J Spine Surg. 2017; 11:33. PMID: 29372137.
      View in: PubMed
    12. Paholpak P, Dedeogullari E, Lee C, Tamai K, Barkoh K, Sessumpun K, Wang JC, Buser Z. Do modic changes, disc degeneration, translation and angular motion affect facet osteoarthritis of the lumbar spine. Eur J Radiol. 2018 Jan; 98:193-199. PMID: 29279162.
      View in: PubMed
    13. Arshi A, Wang C, Park HY, Blumstein GW, Buser Z, Wang JC, Shamie AN, Park DY. Ambulatory anterior cervical discectomy and fusion is associated with a higher risk of revision surgery and perioperative complications: an analysis of a large nationwide database. Spine J. 2017 Nov 16. PMID: 29155340.
      View in: PubMed
    14. Paholpak P, Shah I, Acevedo-Moreno LA, Tamai K, Wang JC, Buser Z. Kinematic analysis of the space available for cord and disc bulging of the thoracic spine using kinematic magnetic resonance imaging (kMRI). Spine J. 2017 Nov 14. PMID: 29154999.
      View in: PubMed
    15. Tamai K, Buser Z, Paholpak P, Sessumpun K, Hsieh PC, Nakamura H, Wang JC. MRI kinematic analysis of T1 sagittal motion between cervical flexion and extension positions in 145 patients. Eur Spine J. 2018 May; 27(5):1034-1041. PMID: 29128915.
      View in: PubMed
    16. Takahashi S, Buser Z, Cohen JR, Roe A, Myhre SL, Meisel HJ, Brodke DS, Yoon ST, Park JB, Wang JC, Youssef JA. Complications Related to the Recombinant Human Bone Morphogenetic Protein 2 Use in Posterior Cervical Fusion. Clin Spine Surg. 2017 Nov; 30(9):E1269-E1273. PMID: 27632774.
      View in: PubMed
    17. Tamai K, Buser Z, Wang C, Paholpak P, Nakamura H, Wang JC, Hsieh PC. The primary diagnosis and the coexisting anxiety disorders have no impact on the additional surgical procedure after spinal cord stimulators implantation: An analysis of 11,029 patients. J Clin Neurosci. 2018 Jan; 47:208-213. PMID: 29037934.
      View in: PubMed
    18. Paholpak P, Tamai K, Shoell K, Sessumpun K, Buser Z, Wang JC. Can multi-positional magnetic resonance imaging be used to evaluate angular parameters in cervical spine? A comparison of multi-positional MRI to dynamic plain radiograph. Eur Spine J. 2017 Sep 25. PMID: 28948406.
      View in: PubMed
    19. Lord EL, Cohen JR, Buser Z, Meisel HJ, Brodke DS, Yoon ST, Youssef JA, Wang JC, Park JB. Trends, Costs, and Complications of Anterior Cervical Discectomy and Fusion With and Without Bone Morphogenetic Protein in the United States Medicare Population. Global Spine J. 2017 Oct; 7(7):603-608. PMID: 28989837.
      View in: PubMed
    20. Dedeogullari E, Paholpak P, Barkoh K, Lucas J, Lee L, Wang C, Hsieh PC, Wang JC, Buser Z. Effect of mental health on post-operative infection rates following cervical spine fusion procedures. J Orthop. 2017 Dec; 14(4):501-506. PMID: 28855766.
      View in: PubMed
    21. Paholpak P, Nazareth A, Barkoh K, Lee LV, Lucas J, Buser Z, Wang JC. Space Available for Cord, Motion, and disc degeneration at the adjacent segments level of degenerative cervical spondylolisthesis using kinematic MRI. J Clin Neurosci. 2017 Nov; 45:89-99. PMID: 28797605.
      View in: PubMed
    22. Wang D, Yuan H, Liu A, Li C, Yang K, Zheng S, Wang L, Wang JC, Buser Z. Analysis of the relationship between the facet fluid sign and lumbar spine motion of degenerative spondylolytic segment using Kinematic MRI. Eur J Radiol. 2017 Sep; 94:6-12. PMID: 28941762.
      View in: PubMed
    23. Ajiboye RM, Zoller SD, D'Oro A, Burke ZD, Sheppard W, Wang C, Buser Z, Wang JC, Pourtaheri S. Utility of Intraoperative Neuromonitoring for Lumbar Pedicle Screw Placement Is Questionable: A Review of 9957 Cases. Spine (Phila Pa 1976). 2017 Jul 01; 42(13):1006-1010. PMID: 27851660.
      View in: PubMed
    24. Lao L, Cohen JR, Buser Z, Brodke DS, Youssef JA, Park JB, Yoon ST, Wang JC, Meisel HJ. Trends Analysis of rhBMP Utilization in Single-Level Posterior Lumbar Interbody Fusion in the United States. Global Spine J. 2017 Oct; 7(7):624-628. PMID: 28989840.
      View in: PubMed
    25. Jakoi AM, Pannu G, D'Oro A, Buser Z, Pham MH, Patel NN, Hsieh PC, Liu JC, Acosta FL, Hah R, Wang JC. The Clinical Correlations between Diabetes, Cigarette Smoking and Obesity on Intervertebral Degenerative Disc Disease of the Lumbar Spine. Asian Spine J. 2017 Jun; 11(3):337-347. PMID: 28670401.
      View in: PubMed
    26. Buser Z, Drapeau S, Stappenbeck F, Pereira RC, Parhami F, Wang JC. Effect of Oxy133, an osteogenic oxysterol, on new bone formation in rat two-level posterolateral fusion model. Eur Spine J. 2017 Nov; 26(11):2763-2772. PMID: 28547574.
      View in: PubMed
    27. Lao L, Cohen JR, Buser Z, Brodke DS, Yoon ST, Youssef JA, Park JB, Meisel HJ, Wang JC. Trends Analysis of rhBMP2 Utilization in Single-Level Anterior Lumbar Interbody Fusion in the United States. Global Spine J. 2018 Apr; 8(2):137-141. PMID: 29662743.
      View in: PubMed
    28. Alobaidaan R, Cohen JR, Lord EL, Buser Z, Yoon ST, Youssef JA, Park JB, Brodke DS, Wang JC, Meisel HJ. Complication Rates in Posterior Lumbar Interbody Fusion (PLIF) Surgery With Human Bone Morphogenetic Protein 2: Medicare Population. Global Spine J. 2017 Dec; 7(8):770-773. PMID: 29238641.
      View in: PubMed
    29. Grisdela P, Buser Z, D'Oro A, Paholpak P, Liu JC, Wang JC. Trends analysis of surgical procedures for cervical degenerative disc disease and myelopathy in patients with tobacco use disorder. Eur Spine J. 2017 Sep; 26(9):2386-2392. PMID: 28488093.
      View in: PubMed
    30. Paholpak P, Nazareth A, Hsieh PC, Buser Z, Wang JC. Kinematic evaluation of cervical sagittal balance and thoracic inlet alignment in degenerative cervical spondylolisthesis using kinematic magnetic resonance imaging. Spine J. 2017 09; 17(9):1272-1284. PMID: 28456677.
      View in: PubMed
    31. Esmail N, Buser Z, Cohen JR, Brodke DS, Meisel HJ, Park JB, Youssef JA, Wang JC, Yoon ST. Postoperative Complications Associated With rhBMP2 Use in Posterior/Posterolateral Lumbar Fusion. Global Spine J. 2018 Apr; 8(2):142-148. PMID: 29662744.
      View in: PubMed
    32. Heindel P, Tuchman A, Hsieh PC, Pham MH, D'Oro A, Patel NN, Jakoi AM, Hah R, Liu JC, Buser Z, Wang JC. Reoperation Rates After Single-level Lumbar Discectomy. Spine (Phila Pa 1976). 2017 Apr 15; 42(8):E496-E501. PMID: 27548580.
      View in: PubMed
    33. Myhre SL, Buser Z, Meisel HJ, Brodke DS, Yoon ST, Wang JC, Park JB, Youssef JA. Trends and Cost of Posterior Cervical Fusions With and Without Recombinant Human Bone Morphogenetic Protein-2 in the US Medicare Population. Global Spine J. 2017 Jun; 7(4):334-342. PMID: 28815161.
      View in: PubMed
    34. Buser Z, Ortega B, D'Oro A, Pannell W, Cohen JR, Wang J, Golish R, Reed M, Wang JC. Spine Degenerative Conditions and Their Treatments: National Trends in the United States of America. Global Spine J. 2018 Feb; 8(1):57-67. PMID: 29456916.
      View in: PubMed
    35. Hindoyan K, Tilan J, Buser Z, Cohen JR, Brodke DS, Youssef JA, Park JB, Yoon ST, Meisel HJ, Wang JC. A Retrospective Analysis of Complications Associated With Bone Morphogenetic Protein 2 in Anterior Lumbar Interbody Fusion. Global Spine J. 2017 Apr; 7(2):148-153. PMID: 28507884.
      View in: PubMed
    36. Sayari AJ, Tuchman A, Cohen JR, Hsieh PC, Buser Z, Wang JC. Risk and Cost of Reoperation After Single-Level Posterior Cervical Foraminotomy: A Large Database Study. Global Spine J. 2017 Apr; 7(2):116-122. PMID: 28507880.
      View in: PubMed
    37. Ren Z, Liu A, Yang K, Wang D, Buser Z, Wang JC. Evaluation of changes in lumbar neuroforaminal dimensions in symptomatic young adults using positional MRI. Eur Spine J. 2017 08; 26(8):1999-2006. PMID: 28116511.
      View in: PubMed
    38. Liu A, Yang K, Wang D, Li C, Ren Z, Yan S, Buser Z, Wang JC. Level of conus medullaris termination in adult population analyzed by kinetic magnetic resonance imaging. Surg Radiol Anat. 2017 Jul; 39(7):759-765. PMID: 28091734.
      View in: PubMed
    39. Pham MH, Buser Z, Wang JC, Acosta FL. Low-magnitude mechanical signals and the spine: A review of current and future applications. J Clin Neurosci. 2017 Jun; 40:18-23. PMID: 28089422.
      View in: PubMed
    40. Ajiboye RM, D'Oro A, Ashana AO, Buerba RA, Lord EL, Buser Z, Wang JC, Pourtaheri S. Routine Use of Intraoperative Neuromonitoring During ACDFs for the Treatment of Spondylotic Myelopathy and Radiculopathy Is Questionable: A Review of 15,395 Cases. Spine (Phila Pa 1976). 2017 Jan 01; 42(1):14-19. PMID: 27120059.
      View in: PubMed
    41. Yuan H, Ding H, Hu L, Buser Z, Zhao H, Li X. Treatment for early postoperative esophageal fistula complicated with anterior cervical surgery. J Orthop Surg (Hong Kong). 2017 Jan; 25(1):2309499016684418. PMID: 28117633.
      View in: PubMed
    42. Schoell K, Buser Z, Jakoi A, Pham M, Patel NN, Hsieh PC, Liu JC, Wang JC. Postoperative complications in patients undergoing minimally invasive sacroiliac fusion. Spine J. 2016 11; 16(11):1324-1332. PMID: 27349627.
      View in: PubMed
    43. Buser Z, Brodke DS, Youssef JA, Meisel HJ, Myhre SL, Hashimoto R, Park JB, Tim Yoon S, Wang JC. Synthetic bone graft versus autograft or allograft for spinal fusion: a systematic review. J Neurosurg Spine. 2016 Oct; 25(4):509-516. PMID: 27231812.
      View in: PubMed
    44. Yao Q, Cohen JR, Buser Z, Park JB, Brodke DS, Meisel HJ, Youssef JA, Wang JC, Yoon ST. Analysis of Recombinant Human Bone Morphogenetic Protein-2 Use in the Treatment of Lumbar Degenerative Spondylolisthesis. Global Spine J. 2016 Dec; 6(8):749-755. PMID: 27853658.
      View in: PubMed
    45. Buser Z, Acosta FL. Stem cells and spinal fusion--are we there yet? Spine J. 2016 Mar; 16(3):400-1. PMID: 27063500.
      View in: PubMed
    46. Weng C, Wang J, Tuchman A, Wang J, Fu C, Hsieh PC, Buser Z, Wang JC. Influence of T1 Slope on the Cervical Sagittal Balance in Degenerative Cervical Spine: An Analysis Using Kinematic MRI. Spine (Phila Pa 1976). 2016 Feb; 41(3):185-90. PMID: 26650871.
      View in: PubMed
    47. D'Oro A, Spoonamore MJ, Cohen JR, Acosta FL, Hsieh PC, Liu JC, Chen TC, Buser Z, Wang JC. Effects of fusion and conservative treatment on disc degeneration and rates of subsequent surgery after thoracolumbar fracture. J Neurosurg Spine. 2016 Mar; 24(3):476-82. PMID: 26637065.
      View in: PubMed
    48. Sayari AJ, Liu Y, Cohen JR, Van Halm-Lutterodt NI, Hai Y, Buser Z, Wang JC. Trends in vertebroplasty and kyphoplasty after thoracolumbar osteoporotic fracture: A large database study from 2005 to 2012. J Orthop. 2015 Dec; 12(Suppl 2):S217-22. PMID: 27047226; PMCID: PMC4796529 [Available on 12/01/16].
    49. Ruofeng Y, Cohen JR, Buser Z, Yoon ST, Meisel HJ, Youssef JA, Park JB, Wang JC, Brodke DS. Trends of Posterior Long Segment Fusion with and without Recombinant Human Bone Morphogenetic Protein 2 in Patients with Scoliosis. Global Spine J. 2016 Aug; 6(5):422-31. PMID: 27433425; PMCID: PMC4947408.
    50. Lao L, Cohen JR, Lord EL, Buser Z, Wang JC. Erratum to: Trends analysis of rhBMP utilization in single-level posterior lumbar fusion (PLF) in the United States. Eur Spine J. 2015 Sep; 24(9):2099. PMID: 26108390.
      View in: PubMed
    51. Zhong G, Buser Z, Lao L, Yin R, Wang JC. Kinematic relationship between missed ligamentum flavum bulge and degenerative factors in the cervical spine. Spine J. 2015 Oct 01; 15(10):2216-21. PMID: 26096477.
      View in: PubMed
    52. Lao L, Cohen JR, Lord EL, Buser Z, Wang JC. Trends analysis of rhBMP utilization in single-level posterior lumbar fusion (PLF) in the United States. Eur Spine J. 2016 Mar; 25(3):783-8. PMID: 26003814.
      View in: PubMed
    53. Yin R, Lord EL, Cohen JR, Buser Z, Lao L, Zhong G, Wang JC. Distribution of Schmorl nodes in the lumbar spine and their relationship with lumbar disk degeneration and range of motion. Spine (Phila Pa 1976). 2015 Jan 01; 40(1):E49-53. PMID: 25341975.
      View in: PubMed
    54. Buser Z, Liu J, Thorne KJ, Coughlin D, Lotz JC. Inflammatory response of intervertebral disc cells is reduced by fibrin sealant scaffold in vitro. J Tissue Eng Regen Med. 2014 Jan; 8(1):77-84. PMID: 22610998.
      View in: PubMed
    55. Buser Z, Kuelling F, Liu J, Liebenberg E, Thorne KJ, Coughlin D, Lotz JC. Biological and biomechanical effects of fibrin injection into porcine intervertebral discs. Spine (Phila Pa 1976). 2011 Aug 15; 36(18):E1201-9. PMID: 21325992.
      View in: PubMed
    56. Allon AA, Aurouer N, Yoo BB, Liebenberg EC, Buser Z, Lotz JC. Structured coculture of stem cells and disc cells prevent disc degeneration in a rat model. Spine J. 2010 Dec; 10(12):1089-97. PMID: 20971687; PMCID: PMC2991542.
    57. Neidlinger-Wilke C, Liedert A, Wuertz K, Buser Z, Rinkler C, Käfer W, Ignatius A, Claes L, Roberts S, Johnson WE. Mechanical stimulation alters pleiotrophin and aggrecan expression by human intervertebral disc cells and influences their capacity to stimulate endothelial migration. Spine (Phila Pa 1976). 2009 Apr 01; 34(7):663-9. PMID: 19333097.
      View in: PubMed