Zhang-Xu Liu, MD, PhD

Title(s)Assistant Professor of Research Medicine
SchoolKeck School of Medicine of USC
Phone+1 323 442 3233
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    Collapse Biography 
    Collapse Awards and Honors
    Japanese Government (Mobusho)1992  - 1997Fellowship
    Japanese Society of Gastroenterology1997Award
    American Digestive Health Foundation1999Travel Award

    Collapse Overview 
    Collapse Overview
    Dr. Liu's research interests include fucnation of liver NK and NKT cells, liver immunology and diseases, innate immunity in drug-induced hepatotoxicity, and immunity in alcoholic hepatitis. He is currently an Associate Editor of World Journal of Gastroenterology.

    Dr. Liu earned his medical degree from Chongqing Medical University. He then went on to complete his master's degree at Sichuan University West China Medical School, followed by a PhD from Tohoku University School of Medicine.

    Collapse Research 
    Collapse Research Activities and Funding
    Immunity in alcoholic hepatitis.
    NIH/NIAAA U01AA021857Sep 20, 2013 - Aug 31, 2018
    Role: Principal Investigator
    Liver innate immunity in drug-induced liver disease.
    NIH/NIDDK R01DK078586Jul 1, 2008 - Jun 30, 2014
    Role: Principal Investigator
    Liver innate immunity in drug-induced liver disease
    NIH/NIDDK K01DK067149Jul 1, 2004 - Jun 30, 2007
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Dara L, Liu ZX, Kaplowitz N. Mechanisms of adaptation and progression in idiosyncratic drug induced liver injury, clinical implications. Liver Int. 2016 Feb; 36(2):158-65. PMID: 26484420; PMCID: PMC4718752 [Available on 02/01/17].
    2. Kaplowitz N, Win S, Than TA, Liu ZX, Dara L. Targeting signal transduction pathways which regulate necrosis in acetaminophen hepatotoxicity. J Hepatol. 2015 Jul; 63(1):5-7. PMID: 25770661.
      View in: PubMed
    3. Wen SL, Gao JH, Yang WJ, Lu YY, Tong H, Huang ZY, Liu ZX, Tang CW. Celecoxib attenuates hepatic cirrhosis through inhibition of epithelial-to-mesenchymal transition of hepatocytes. J Gastroenterol Hepatol. 2014 Nov; 29(11):1932-42. PMID: 24909904.
      View in: PubMed
    4. Gao JH, Wen SL, Yang WJ, Lu YY, Tong H, Huang ZY, Liu ZX, Tang CW. Celecoxib ameliorates portal hypertension of the cirrhotic rats through the dual inhibitory effects on the intrahepatic fibrosis and angiogenesis. PLoS One. 2013; 8(7):e69309. PMID: 23922700; PMCID: PMC3724827.
    5. Han D, Dara L, Win S, Than TA, Yuan L, Abbasi SQ, Liu ZX, Kaplowitz N. Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria. Trends Pharmacol Sci. 2013 Apr; 34(4):243-53. PMID: 23453390; PMCID: PMC3622802.
    6. Inokuchi S, Tsukamoto H, Park E, Liu ZX, Brenner DA, Seki E. Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. Alcohol Clin Exp Res. 2011 Aug; 35(8):1509-18. PMID: 21463341; PMCID: PMC3131439.
    7. Kaplowitz N, Shinohara M, Liu ZX, Han D. How to protect against acetaminophen: don't ask for JUNK. Gastroenterology. 2008 Oct; 135(4):1047-51. PMID: 18782575.
      View in: PubMed
    8. Liu ZX, Kaplowitz N. Role of innate immunity in acetaminophen-induced hepatotoxicity. Expert Opin Drug Metab Toxicol. 2006 Aug; 2(4):493-503. PMID: 16859400.
      View in: PubMed
    9. Gunawan BK, Liu ZX, Han D, Hanawa N, Gaarde WA, Kaplowitz N. c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity. Gastroenterology. 2006 Jul; 131(1):165-78. PMID: 16831600.
      View in: PubMed
    10. Liu ZX, Han D, Gunawan B, Kaplowitz N. Neutrophil depletion protects against murine acetaminophen hepatotoxicity. Hepatology. 2006 Jun; 43(6):1220-30. PMID: 16729305.
      View in: PubMed
    11. Liu ZX, Govindarajan S, Kaplowitz N. Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity. Gastroenterology. 2004 Dec; 127(6):1760-74. PMID: 15578514.
      View in: PubMed
    12. Minagawa M, Deng Q, Liu ZX, Tsukamoto H, Dennert G. Activated natural killer T cells induce liver injury by Fas and tumor necrosis factor-alpha during alcohol consumption. Gastroenterology. 2004 May; 126(5):1387-99. PMID: 15131799.
      View in: PubMed
    13. Arai K, Liu ZX, Lane T, Dennert G. IP-10 and Mig facilitate accumulation of T cells in the virus-infected liver. Cell Immunol. 2002 Sep; 219(1):48-56. PMID: 12473267.
      View in: PubMed
    14. Liu ZX, Kaplowitz N. Immune-mediated drug-induced liver disease. Clin Liver Dis. 2002 Aug; 6(3):755-74. PMID: 12362579.
      View in: PubMed
    15. Liu ZX, Nishida H, He JW, Lai MM, Feng N, Dennert G. Hepatitis C virus genotype 1b core protein does not exert immunomodulatory effects on virus-induced cellular immunity. J Virol. 2002 Feb; 76(3):990-7. PMID: 11773374; PMCID: PMC135789.