Wensha Yang, PhD

Title(s)Associate Professor Of Clinical Radiation Oncology
SchoolKeck School of Medicine of Usc
Address1441 Eastlake Ave.
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 865 3089
EmailWensha.Yang@med.usc.edu
ORCID ORCID Icon0000-0002-7274-9454 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of Virginia, Charlottesville, VAclinical training01/2010Medical Physics
    University of Wisconsin-Madison, Madison, WIPh.D.05/2005Material Chemistry
    University of Science and Technology of China, Hefei, ChinaB.A.07/2001Material Chemistry

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    Collapse Overview
    Dr. Wensha Yang is an Associate Professor of Clinical Radiation Oncology-Medical Physics at USC Norris Cancer Hospital and USC+Los Angeles County Medical Center. She joined USC in March 2019. Dr. Yang graduated from University of Science and Technology of China with a Bachelor of Arts degree in material chemistry. She received her doctorate degree from the University of Wisconsin-Madison, and completed her clinical training in medical physics at University of Virginia in 2010. After completing her clinical training, Dr. Yang became a medical physicist on the faculty at Cedars Sinai Medical Center. Dr. Yang has published in multiple areas including material chemistry, medical physics, medical dosimetry and imaging guided radiation therapy. She had received NIH funding for her research in the area of MRI guided radiation therapy.

    Medical Physics Expertise: SBRT, IGRT, DIBH, 4DCT, TBI, TSET, HDR, LDR

    Languages Spoken: English and Chinese (Mandarin)
    Collapse Global Health Equity

    Collapse Research 
    Collapse Research Activities and Funding
    Multi-Task MR Simulation for Abdominal Radiation Treatment Planning
    NIH R01EB029088Jul 1, 2020 - Mar 31, 2024
    Role: Co-Principal Investigator (contact PI: Dr. Zhaoyang Fan)
    Novel four dimensional magnetic resonance imaging to monitor pancreatic tumor infiltrating blood vessels and tumor response to chemoradiation therapy
    NIH R21CA234637Jul 17, 2019 - Jun 30, 2021
    Role: Principle Investigator (co-PI: Dr. Zhaoyang Fan)
    Multi-parametric MRI Guided Liver Stereotactic Body Radiation Therapy
    NIH, CTSI May 1, 2015 - May 1, 2016
    Role: Principal Investigator
    Improving Pancreas RT Plans using Respiration-driven Anatomic Deformation
    NIH R03CA173273Feb 1, 2013 - Jan 31, 2015
    Role: Principal Investigator
    Use of Quantum Dot Semiconductor nanoparticle to mediate energy transfer from mega-voltage X-ray to Photofrin for enhancement in radiation therapy treatment
    Virginia Commonwealth Health Research Board Award Jul 1, 2008 - Jul 1, 2010
    Role: Multiple Principal Investigator
    Modification of Semiconductor nanoparticle surface with Photofrin for radiosensitization in radiation therapy Description: To develop a conjugation protocol to modify semiconductor nanoparticle surface with Photofrin
    Coulter Foundation Jul 1, 2007 - Jul 1, 2008
    Role: Co-Investigator
    Description: Synthesis of nanoparticle.
    Use of Quantum Dot Semiconductor nanoparticle to mediate energy transfer from mega-voltage X-ray to Photofrin for enhancement in radiation therapy treatment
    University of Virginia, Cancer Center Grant Jan 1, 2007 - Dec 1, 2009
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Automatic differentiation of Grade I and II meningiomas on magnetic resonance image using an asymmetric convolutional neural network. Sci Rep. 2022 03 09; 12(1):3806. Vassantachart A, Cao Y, Gribble M, Guzman S, Ye JC, Hurth K, Mathew A, Zada G, Fan Z, Chang EL, Yang W. PMID: 35264655; PMCID: PMC8907289.
      View in: PubMed   Mentions:
    2. Automatic segmentation of high-risk clinical target volume for tandem-and-ovoids brachytherapy patients using an asymmetric dual-path convolutional neural network. Med Phys. 2022 Mar; 49(3):1712-1722. Cao Y, Vassantachart A, Ragab O, Bian S, Mitra P, Xu Z, Gallogly AZ, Cui J, Shen ZL, Balik S, Gribble M, Chang EL, Fan Z, Yang W. PMID: 35080018.
      View in: PubMed   Mentions:
    3. Voxelwise Prediction of Recurrent High-Grade Glioma via Proximity Estimation-Coupled Multidimensional Support Vector Machine. Int J Radiat Oncol Biol Phys. 2022 04 01; 112(5):1279-1287. Lao Y, Ruan D, Vassantachart A, Fan Z, Ye JC, Chang EL, Chin R, Kaprealian T, Zada G, Shiroishi MS, Sheng K, Yang W. PMID: 34963559; PMCID: PMC8923952.
      View in: PubMed   Mentions:
    4. Anatomical and topographical variations in the distribution of brain metastases based on primary cancer origin and molecular subtypes: a systematic review. Neurooncol Adv. 2022 Jan-Dec; 4(1):vdab170. Cardinal T, Pangal D, Strickland BA, Newton P, Mahmoodifar S, Mason J, Craig D, Simon T, Tew BY, Yu M, Yang W, Chang E, Cabeen RP, Ruzevick J, Toga AW, Neman J, Salhia B, Zada G. PMID: 35024611; PMCID: PMC8739649.
      View in: PubMed   Mentions:
    5. Bladder surface dose modeling in prostate cancer radiotherapy: An analysis of motion-induced variations and the cumulative dose across the treatment. Med Phys. 2021 Dec; 48(12):8024-8036. Lao Y, Cao M, Yang Y, Kishan AU, Yang W, Wang Y, Sheng K. PMID: 34734414; PMCID: PMC8683601.
      View in: PubMed   Mentions:
    6. Surviving Over a Decade With Glioblastoma: A Clinical Course Characterized by Multiple Recurrences, Numerous Salvage Treatments, and Novel Use of Cesium-131 Tiles. Cureus. 2021 Nov; 13(11):e19573. Mehta S, Vassantachart AK, Fossum CC, Yang W, Shen ZL, Chang KE, Ye JC, Chen TC, Chang EL. PMID: 34926045; PMCID: PMC8671070.
      View in: PubMed   Mentions:
    7. Commensal bacteria and fungi differentially regulate tumor responses to radiation therapy. Cancer Cell. 2021 09 13; 39(9):1202-1213.e6. Shiao SL, Kershaw KM, Limon JJ, You S, Yoon J, Ko EY, Guarnerio J, Potdar AA, McGovern DPB, Bose S, Dar TB, Noe P, Lee J, Kubota Y, Maymi VI, Davis MJ, Henson RM, Choi RY, Yang W, Tang J, Gargus M, Prince AD, Zumsteg ZS, Underhill DM. PMID: 34329585; PMCID: PMC8830498.
      View in: PubMed   Mentions: 1     Fields:    
    8. Quantitative Characterization of Tumor Proximity to Stem Cell Niches: Implications on Recurrence and Survival in GBM Patients. Int J Radiat Oncol Biol Phys. 2021 07 15; 110(4):1180-1188. Lao Y, Yu V, Pham A, Wang T, Cui J, Gallogly A, Chang E, Fan Z, Kaprealian T, Yang W, Sheng K. PMID: 33600888; PMCID: PMC8238898.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Automatic detection and segmentation of multiple brain metastases on magnetic resonance image using asymmetric UNet architecture. Phys Med Biol. 2021 01 13; 66(1):015003. Cao Y, Vassantachart A, Ye JC, Yu C, Ruan D, Sheng K, Lao Y, Shen ZL, Balik S, Bian S, Zada G, Shiu A, Chang EL, Yang W. PMID: 33186927.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Fully automated multiorgan segmentation in abdominal magnetic resonance imaging with deep neural networks. Med Phys. 2020 Oct; 47(10):4971-4982. Chen Y, Ruan D, Xiao J, Wang L, Sun B, Saouaf R, Yang W, Li D, Fan Z. PMID: 32748401; PMCID: PMC7722015.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    11. Quantifying vascular invasion in pancreatic cancer-a contrast CT based method for surgical resectability evaluation. Phys Med Biol. 2020 06 01; 65(10):105012. Lao Y, David J, Fan Z, Bian S, Shiu A, Chang EL, Sheng K, Yang W, Tuli R. PMID: 32187583; PMCID: PMC7316342.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Deformable alignment of longitudinal postoperative brain GBM scans using deep learning. Proc. SPIE 11313, Medical Imaging 2020: Image Processing, 113130O (10 March 2020). 2020. . View Publication.
    13. Six-dimensional quantitative DCE MR Multitasking of the entire abdomen: Method and application to pancreatic ductal adenocarcinoma. Magn Reson Med. 2020 08; 84(2):928-948. Wang N, Gaddam S, Wang L, Xie Y, Fan Z, Yang W, Tuli R, Lo S, Hendifar A, Pandol S, Christodoulou AG, Li D. PMID: 31961967; PMCID: PMC7323577.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    14. Combined morphologic and metabolic pipeline for Positron emission tomography/computed tomography based radiotherapy response evaluation in locally advanced pancreatic adenocarcinoma. Phys Imaging Radiat Oncol. 2019 Jan; 9:28-34. Lao Y, David J, Torosian A, Placencio V, Wang Y, Hendifar A, Yang W, Tuli R. PMID: 32190750; PMCID: PMC7079767.
      View in: PubMed   Mentions: 1  
    15. A post-processing method based on interphase motion correction and averaging to improve image quality of 4D magnetic resonance imaging: a clinical feasibility study. Br J Radiol. 2019 Mar; 92(1095):20180424. Deng Z, Pang J, Lao Y, Bi X, Wang G, Chen Y, Fenchel M, Tuli R, Li D, Yang W, Fan Z. PMID: 30604622; PMCID: PMC6541178.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. Discriminating lung adenocarcinoma from lung squamous cell carcinoma using respiration-induced tumor shape changes. Phys Med Biol. 2018 11 07; 63(21):215027. Lao Y, David J, Mirhadi A, Lepore N, Sandler H, Wang Y, Tuli R, Yang W. PMID: 30403196; PMCID: PMC6310012.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    17. Novel 4D-MRI of tumor infiltrating vasculature: characterizing tumor and vessel volume motion for selective boost volume definition in pancreatic radiotherapy. Radiat Oncol. 2018 Oct 01; 13(1):191. Yang W, Fan Z, Deng Z, Pang J, Bi X, Fraass BA, Sandler H, Li D, Tuli R. PMID: 30285889; PMCID: PMC6167784.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    18. Improved vessel-tissue contrast and image quality in 3D radial sampling-based 4D-MRI. J Appl Clin Med Phys. 2017 Nov; 18(6):250-257. Deng Z, Yang W, Pang J, Bi X, Tuli R, Li D, Fan Z. PMID: 28980395; PMCID: PMC5689937.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    19. Influence of Body Mass Index and Albumin on Perioperative Morbidity and Clinical Outcomes in Resected Pancreatic Adenocarcinoma. PLoS One. 2016; 11(3):e0152172. Hendifar A, Osipov A, Khanuja J, Nissen N, Naziri J, Yang W, Li Q, Tuli R. PMID: 27015568; PMCID: PMC4807776.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    20. Nonlocal Means Denoising of Self-Gated and k-Space Sorted 4-Dimensional Magnetic Resonance Imaging Using Block-Matching and 3-Dimensional Filtering: Implications for Pancreatic Tumor Registration and Segmentation. Int J Radiat Oncol Biol Phys. 2016 07 01; 95(3):1058-1066. Jin J, McKenzie E, Fan Z, Tuli R, Deng Z, Pang J, Fraass B, Li D, Sandler H, Yang G, Sheng K, Gou S, Yang W. PMID: 27302516; PMCID: PMC4911822.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    21. Geometric validation of self-gating k-space-sorted 4D-MRI vs 4D-CT using a respiratory motion phantom. Med Phys. 2015 Oct; 42(10):5787-97. Yue Y, Fan Z, Yang W, Pang J, Deng Z, McKenzie E, Tuli R, Wallace R, Li D, Fraass B. PMID: 26429253; PMCID: PMC4575318.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    22. Four-Dimensional Magnetic Resonance Imaging With 3-Dimensional Radial Sampling and Self-Gating-Based K-Space Sorting: Early Clinical Experience on Pancreatic Cancer Patients. Int J Radiat Oncol Biol Phys. 2015 Dec 01; 93(5):1136-43. Yang W, Fan Z, Tuli R, Deng Z, Pang J, Wachsman A, Reznik R, Sandler H, Li D, Fraass BA. PMID: 26452571; PMCID: PMC4654642.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    23. Four-dimensional MRI using three-dimensional radial sampling with respiratory self-gating to characterize temporal phase-resolved respiratory motion in the abdomen. Magn Reson Med. 2016 Apr; 75(4):1574-85. Deng Z, Pang J, Yang W, Yue Y, Sharif B, Tuli R, Li D, Fraass B, Fan Z. PMID: 25981762; PMCID: PMC4644523.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    24. Clinical experience using a video-guided spirometry system for deep inhalation breath-hold radiotherapy of left-sided breast cancer. J Appl Clin Med Phys. 2015 Mar 08; 16(2):5218. Yang W, McKenzie EM, Burnison M, Shiao S, Mirhadi A, Hakimian B, Reznik R, Tuli R, Sandler H, Fraass BA. PMID: 26103193; PMCID: PMC5690070.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    25. Dosimetric evaluation of simultaneous integrated boost during stereotactic body radiation therapy for pancreatic cancer. Med Dosim. 2015; 40(1):47-52. Yang W, Reznik R, Fraass BA, Nissen N, Hendifar A, Wachsman A, Sandler H, Tuli R. PMID: 25445989.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    26. Adequacy of inhale/exhale breathhold CT based ITV margins and image-guided registration for free-breathing pancreas and liver SBRT. Radiat Oncol. 2014 Jan 09; 9:11. Yang W, Fraass BA, Reznik R, Nissen N, Lo S, Jamil LH, Gupta K, Sandler H, Tuli R. PMID: 24401365; PMCID: PMC3896695.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    27. Computed tomography-based anatomic assessment overestimates local tumor recurrence in patients with mass-like consolidation after stereotactic body radiotherapy for early-stage non-small cell lung cancer. Int J Radiat Oncol Biol Phys. 2012 Dec 01; 84(5):1071-7. Dunlap NE, Yang W, McIntosh A, Sheng K, Benedict SH, Read PW, Larner JM. PMID: 22898383.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    28. Feasibility of non-coplanar tomotherapy for lung cancer stereotactic body radiation therapy. Technol Cancer Res Treat. 2011 Aug; 10(4):307-15. Yang W, Jones R, Lu W, Geesey C, Benedict S, Read P, Larner J, Sheng K. PMID: 21728387.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    29. Radiation therapy of post-mastectomy patients with positive nodes using fixed beam tomotherapy. Radiother Oncol. 2011 Aug; 100(2):247-52. Jones R, Yang W, Read P, Sheng K. PMID: 21641066.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    30. 3D dose verification using tomotherapy CT detector array. Int J Radiat Oncol Biol Phys. 2012 Feb 01; 82(2):1013-20. Sheng K, Jones R, Yang W, Saraiya S, Schneider B, Chen Q, Sobering G, Olivera G, Read P. PMID: 21362580.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansPHPublic Health
    31. Standardized evaluation of simultaneous integrated boost plans on volumetric modulated arc therapy. Phys Med Biol. 2011 Jan 21; 56(2):327-39. Yang W, Jones R, Read P, Benedict S, Sheng K. PMID: 21160109.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    32. Tumor cell apoptosis induced by nanoparticle conjugate in combination with radiation therapy. Nanotechnology. 2010 Nov 26; 21(47):475103. Wang L, Yang W, Read P, Larner J, Sheng K. PMID: 21030759.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    33. Dosimetric comparison of 6 MV and 15 MV single arc rapidarc to helical TomoTherapy for the treatment of pancreatic cancer. Med Dosim. 2011; 36(3):317-20. Cai J, Yue J, McLawhorn R, Yang W, Wijesooriya K, Dunlap NE, Sheng K, Yin FF, Benedict SH. PMID: 20846850.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    34. Comparison of Elekta VMAT with helical tomotherapy and fixed field IMRT: plan quality, delivery efficiency and accuracy. Med Phys. 2010 Mar; 37(3):1350-9. Rao M, Yang W, Chen F, Sheng K, Ye J, Mehta V, Shepard D, Cao D. PMID: 20384272.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansPHPublic Health
    35. Helical tomotherapy-based STAT stereotactic body radiation therapy: Dosimetric evaluation for a real-time SBRT treatment planning and delivery program. Med Dosim. 2010; 35(4):312-9. Dunlap N, McIntosh A, Sheng K, Yang W, Turner B, Shoushtari A, Sheehan J, Jones DR, Lu W, Ruchala K, Olivera G, Parnell D, Larner JL, Benedict SH, Read PW. PMID: 21055611.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    36. Tumor cell survival dependence on helical tomotherapy, continuous arc and segmented dose delivery. Phys Med Biol. 2009 Nov 07; 54(21):6635-43. Yang W, Wang L, Larner J, Read P, Benedict S, Sheng K. PMID: 19826199.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    37. Spatial control in the heterogeneous nucleation of water. Applied Physics Letters. 2009; 95(9):4101 . Varanasi KK, Hsu M, Bhate N, Yang W, Deng T. View Publication.
    38. Chest wall volume receiving >30 Gy predicts risk of severe pain and/or rib fracture after lung stereotactic body radiotherapy. Int J Radiat Oncol Biol Phys. 2010 Mar 01; 76(3):796-801. Dunlap NE, Cai J, Biedermann GB, Yang W, Benedict SH, Sheng K, Schefter TE, Kavanagh BD, Larner JM. PMID: 19427740.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansPHPublic Health
    39. The implication of non-cyclic intrafractional longitudinal motion in SBRT by TomoTherapy. Phys Med Biol. 2009 May 07; 54(9):2875-84. Yang W, Van Ausdal R, Read P, Larner J, Benedict S, Sheng K. PMID: 19384001.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    40. Semiconductor nanoparticles as energy mediators for photosensitizer-enhanced radiotherapy. Int J Radiat Oncol Biol Phys. 2008 Nov 01; 72(3):633-5. Yang W, Read PW, Mi J, Baisden JM, Reardon KA, Larner JM, Helmke BP, Sheng K. PMID: 19014777.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    41. Covalent molecular functionalization of diamond thin-film transistors. Diamond and Related Materials. 2007; 16(8):1608-1615. Sun B., Baker S.E, Butler J.E, Kim H., Russell J.N, Shang L., Tse K.Y, Yang W, Hamers R.J. View Publication.
    42. Direct electrical detection of antigen-antibody binding on diamond and silicon substrates using electrical impedance spectroscopy. Analyst. 2007 Apr; 132(4):296-306. Yang W, Butler JE, Russell JN, Hamers RJ. PMID: 17554408.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    43. Electrical properties of diamond surfaces functionalized with molecular monolayers. J Phys Chem B. 2005 May 05; 109(17):8523-32. Tse KY, Nichols BM, Yang W, Butler JE, Russell JN, Hamers RJ. PMID: 16852003.
      View in: PubMed   Mentions: 3     Fields:    
    44. Electrically Addressable Biomolecular Functionalization of Conductive Nanocrystalline Diamond Thin Films. Chemistry of Materials. 2005; 5(17):938-940. . View Publication.
    45. Molecular and biomolecular monolayers on diamond as an interface to biology. Diamond and Related Materials . 2005; 14(3-7):661-668. . View Publication.
    46. Fabrication and characterization of a biologically sensitive field-effect transistor using a nanocrystalline diamond thin film. Applied Physics Letters. 2004; 85:3626. . View Publication.
    47. Electrically Addressable Biomolecular Functionalization of Carbon Nanotube and Carbon Nanofiber Electrodes. Nano Letters. 2004; 9(4):1713-1716. Lee CS, Baker S, Marcus M, Yang W, Hamers RJ. View Publication.
    48. Interfacial electrical properties of DNA-modified diamond thin films: intrinsic response and hybridization-induced field effects. Langmuir. 2004 Aug 03; 20(16):6778-87. Yang W, Butler JE, Russell JN, Hamers RJ. PMID: 15274585.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    49. Invasive cleavage reactions on DNA-modified diamond surfaces. Biopolymers. 2004 Apr 05; 73(5):606-13. Lu M, Knickerbocker T, Cai W, Yang W, Hamers RJ, Smith LM. PMID: 15048784.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    50. Preparation and Electrochemical Characterization of DNA-modified Nanocrystalline Diamond Films. MRS Online Proceedings Library. 2002; (737):44. . View Publication.
    51. DNA-modified nanocrystalline diamond thin-films as stable, biologically active substrates. Nat Mater. 2002 Dec; 1(4):253-7. Yang W, Auciello O, Butler JE, Cai W, Carlisle JA, Gerbi JE, Gruen DM, Knickerbocker T, Lasseter TL, Russell JN, Smith LM, Hamers RJ. PMID: 12618788.
      View in: PubMed   Mentions: 41     Fields:    Translation:Cells
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