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Wensha Yang, PhD

Title(s)Associate Professor Of Clinical Radiation Oncology
Phone+1 323 865 3089
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    Collapse Biography 
    Collapse Education and Training
    University of Virginia, Charlottesville, VAclinical training01/2010Medical Physics
    University of Wisconsin-Madison, Madison, WIPh.D.05/2005Material Chemistry
    University of Science and Technology of China, Hefei, ChinaB.A.07/2001Material Chemistry

    Collapse Overview 
    Collapse Overview
    Dr. Wensha Yang is an Associate Professor of Clinical Radiation Oncology-Medical Physics at USC Norris Cancer Hospital and USC + Los Angeles County Medical Center. She joined USC in March 2019.

    Dr. Wensha Yang graduated from University of Science and Technology of China with a Bachelor of Arts degree in material chemistry. She received her doctorate degree from the University of Wisconsin-Madison, and completed her clinical training in medical physics at University of Virginia in 2010.

    After completing her clinical training, Dr. Yang became a medical physicist on the faculty at Cedars Sinai Medical Center. Dr. Yang has published in multiple areas including material chemistry, medical physics, medical dosimetry and imaging guided radiation therapy. She had received NIH funding for her research in the area of MRI guided radiation therapy.

    Medical Physics Expertise: SBRT, IGRT, DIBH, 4DCT, TBI, TSET, HDR

    Languages Spoken: English and Chinese (Mandarin)

    Collapse Research 
    Collapse Research Activities and Funding
    Novel four dimensional magnetic resonance imaging to monitor pancreatic tumor infiltrating blood vessels and tumor response to chemoradiation therapy
    NIH/NCI R21CA234637Jul 17, 2019 - Jun 30, 2021
    Role: Principal Investigator
    Multi-parametric MRI Guided Liver Stereotactic Body Radiation Therapy
    NIH, CTSI May 1, 2015 - May 1, 2016
    Role: Principal Investigator
    Improving Pancreas RT Plans using Respiration-driven Anatomic Deformation
    NIH R03CA173273Feb 1, 2013 - Jan 31, 2015
    Role: Principal Investigator
    Use of Quantum Dot Semiconductor nanoparticle to mediate energy transfer from mega-voltage X-ray to Photofrin for enhancement in radiation therapy treatment
    Virginia Commonwealth Health Research Board Award Jul 1, 2008 - Jul 1, 2010
    Role: Multiple Principal Investigator
    Modification of Semiconductor nanoparticle surface with Photofrin for radiosensitization in radiation therapy Description: To develop a conjugation protocol to modify semiconductor nanoparticle surface with Photofrin
    Coulter Foundation Jul 1, 2007 - Jul 1, 2008
    Role: Co-Investigator
    Role Description: Synthesis of nanoparticle.
    Use of Quantum Dot Semiconductor nanoparticle to mediate energy transfer from mega-voltage X-ray to Photofrin for enhancement in radiation therapy treatment
    University of Virginia, Cancer Center Grant Jan 1, 2007 - Dec 1, 2009
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Deng Z, Pang J, Lao Y, Bi X, Wang G, Chen Y, Fenchel M, Tuli R, Li D, Yang W, Fan Z. A post-processing method based on interphase motion correction and averaging to improve image quality of 4D magnetic resonance imaging: a clinical feasibility study. Br J Radiol. 2019 Mar; 92(1095):20180424. PMID: 30604622.
      View in: PubMed
    2. Lao Y, David J, Torossian A, Placencio V, Wang Y, Hendifar A, Yang W, Tuli R.Combined morphologic and metabolic pipeline for radiation therapy response evaluation in locally advanced pancreatic adenocarcinoma. Physics and Imaging in Radiation Oncology. 2019; 9:28-34.
    3. Lao Y, David J, Mirhadi A, Lepore N, Sandler H, Wang Y, Tuli R, Yang W. Discriminating lung adenocarcinoma from lung squamous cell carcinoma using respiration-induced tumor shape changes. Phys Med Biol. 2018 11 07; 63(21):215027. PMID: 30403196.
      View in: PubMed
    4. Yang W, Fan Z, Deng Z, Pang J, Bi X, Fraass BA, Sandler H, Li D, Tuli R. Novel 4D-MRI of tumor infiltrating vasculature: characterizing tumor and vessel volume motion for selective boost volume definition in pancreatic radiotherapy. Radiat Oncol. 2018 Oct 01; 13(1):191. PMID: 30285889.
      View in: PubMed
    5. Deng Z, Yang W, Pang J, Bi X, Tuli R, Li D, Fan Z. Improved vessel-tissue contrast and image quality in 3D radial sampling-based 4D-MRI. J Appl Clin Med Phys. 2017 Nov; 18(6):250-257. PMID: 28980395.
      View in: PubMed
    6. Hendifar A, Osipov A, Khanuja J, Nissen N, Naziri J, Yang W, Li Q, Tuli R. Influence of Body Mass Index and Albumin on Perioperative Morbidity and Clinical Outcomes in Resected Pancreatic Adenocarcinoma. PLoS One. 2016; 11(3):e0152172. PMID: 27015568.
      View in: PubMed
    7. Jin J, McKenzie E, Fan Z, Tuli R, Deng Z, Pang J, Fraass B, Li D, Sandler H, Yang G, Sheng K, Gou S, Yang W. Nonlocal Means Denoising of Self-Gated and k-Space Sorted 4-Dimensional Magnetic Resonance Imaging Using Block-Matching and 3-Dimensional Filtering: Implications for Pancreatic Tumor Registration and Segmentation. Int J Radiat Oncol Biol Phys. 2016 07 01; 95(3):1058-1066. PMID: 27302516.
      View in: PubMed
    8. Yue Y, Fan Z, Yang W, Pang J, Deng Z, McKenzie E, Tuli R, Wallace R, Li D, Fraass B. Geometric validation of self-gating k-space-sorted 4D-MRI vs 4D-CT using a respiratory motion phantom. Med Phys. 2015 Oct; 42(10):5787-97. PMID: 26429253.
      View in: PubMed
    9. Yang W, Fan Z, Tuli R, Deng Z, Pang J, Wachsman A, Reznik R, Sandler H, Li D, Fraass BA. Four-Dimensional Magnetic Resonance Imaging With 3-Dimensional Radial Sampling and Self-Gating-Based K-Space Sorting: Early Clinical Experience on Pancreatic Cancer Patients. Int J Radiat Oncol Biol Phys. 2015 Dec 01; 93(5):1136-43. PMID: 26452571.
      View in: PubMed
    10. Deng Z, Pang J, Yang W, Yue Y, Sharif B, Tuli R, Li D, Fraass B, Fan Z. Four-dimensional MRI using three-dimensional radial sampling with respiratory self-gating to characterize temporal phase-resolved respiratory motion in the abdomen. Magn Reson Med. 2016 Apr; 75(4):1574-85. PMID: 25981762.
      View in: PubMed
    11. Yang W, McKenzie EM, Burnison M, Shiao S, Mirhadi A, Hakimian B, Reznik R, Tuli R, Sandler H, Fraass BA. Clinical experience using a video-guided spirometry system for deep inhalation breath-hold radiotherapy of left-sided breast cancer. J Appl Clin Med Phys. 2015 Mar 08; 16(2):5218. PMID: 26103193.
      View in: PubMed
    12. Yang W, Reznik R, Fraass BA, Nissen N, Hendifar A, Wachsman A, Sandler H, Tuli R. Dosimetric evaluation of simultaneous integrated boost during stereotactic body radiation therapy for pancreatic cancer. Med Dosim. 2015; 40(1):47-52. PMID: 25445989.
      View in: PubMed
    13. Yang W, Fraass BA, Reznik R, Nissen N, Lo S, Jamil LH, Gupta K, Sandler H, Tuli R. Adequacy of inhale/exhale breathhold CT based ITV margins and image-guided registration for free-breathing pancreas and liver SBRT. Radiat Oncol. 2014 Jan 09; 9:11. PMID: 24401365.
      View in: PubMed
    14. Dunlap NE, Yang W, McIntosh A, Sheng K, Benedict SH, Read PW, Larner JM. Computed tomography-based anatomic assessment overestimates local tumor recurrence in patients with mass-like consolidation after stereotactic body radiotherapy for early-stage non-small cell lung cancer. Int J Radiat Oncol Biol Phys. 2012 Dec 01; 84(5):1071-7. PMID: 22898383.
      View in: PubMed
    15. Yang W, Jones R, Lu W, Geesey C, Benedict S, Read P, Larner J, Sheng K. Feasibility of non-coplanar tomotherapy for lung cancer stereotactic body radiation therapy. Technol Cancer Res Treat. 2011 Aug; 10(4):307-15. PMID: 21728387.
      View in: PubMed
    16. Jones R, Yang W, Read P, Sheng K. Radiation therapy of post-mastectomy patients with positive nodes using fixed beam tomotherapy. Radiother Oncol. 2011 Aug; 100(2):247-52. PMID: 21641066.
      View in: PubMed
    17. Sheng K, Jones R, Yang W, Saraiya S, Schneider B, Chen Q, Sobering G, Olivera G, Read P. 3D dose verification using tomotherapy CT detector array. Int J Radiat Oncol Biol Phys. 2012 Feb 01; 82(2):1013-20. PMID: 21362580.
      View in: PubMed
    18. Yang W, Jones R, Read P, Benedict S, Sheng K. Standardized evaluation of simultaneous integrated boost plans on volumetric modulated arc therapy. Phys Med Biol. 2011 Jan 21; 56(2):327-39. PMID: 21160109.
      View in: PubMed
    19. Wang L, Yang W, Read P, Larner J, Sheng K. Tumor cell apoptosis induced by nanoparticle conjugate in combination with radiation therapy. Nanotechnology. 2010 Nov 26; 21(47):475103. PMID: 21030759.
      View in: PubMed
    20. Cai J, Yue J, McLawhorn R, Yang W, Wijesooriya K, Dunlap NE, Sheng K, Yin FF, Benedict SH. Dosimetric comparison of 6 MV and 15 MV single arc rapidarc to helical TomoTherapy for the treatment of pancreatic cancer. Med Dosim. 2011; 36(3):317-20. PMID: 20846850.
      View in: PubMed
    21. Rao M, Yang W, Chen F, Sheng K, Ye J, Mehta V, Shepard D, Cao D. Comparison of Elekta VMAT with helical tomotherapy and fixed field IMRT: plan quality, delivery efficiency and accuracy. Med Phys. 2010 Mar; 37(3):1350-9. PMID: 20384272.
      View in: PubMed
    22. Dunlap N, McIntosh A, Sheng K, Yang W, Turner B, Shoushtari A, Sheehan J, Jones DR, Lu W, Ruchala K, Olivera G, Parnell D, Larner JL, Benedict SH, Read PW. Helical tomotherapy-based STAT stereotactic body radiation therapy: Dosimetric evaluation for a real-time SBRT treatment planning and delivery program. Med Dosim. 2010; 35(4):312-9. PMID: 21055611.
      View in: PubMed
    23. Yang W, Wang L, Larner J, Read P, Benedict S, Sheng K. Tumor cell survival dependence on helical tomotherapy, continuous arc and segmented dose delivery. Phys Med Biol. 2009 Nov 07; 54(21):6635-43. PMID: 19826199.
      View in: PubMed
    24. Varanasi KK, Hsu M, Bhate N, Yang W, Deng T.Spatial control in the heterogeneous nucleation of water. Applied Physics Letters. 2009; 95(9):4101 .
    25. Dunlap NE, Cai J, Biedermann GB, Yang W, Benedict SH, Sheng K, Schefter TE, Kavanagh BD, Larner JM. Chest wall volume receiving >30 Gy predicts risk of severe pain and/or rib fracture after lung stereotactic body radiotherapy. Int J Radiat Oncol Biol Phys. 2010 Mar 01; 76(3):796-801. PMID: 19427740.
      View in: PubMed
    26. Yang W, Van Ausdal R, Read P, Larner J, Benedict S, Sheng K. The implication of non-cyclic intrafractional longitudinal motion in SBRT by TomoTherapy. Phys Med Biol. 2009 May 07; 54(9):2875-84. PMID: 19384001.
      View in: PubMed
    27. Yang W, Read PW, Mi J, Baisden JM, Reardon KA, Larner JM, Helmke BP, Sheng K. Semiconductor nanoparticles as energy mediators for photosensitizer-enhanced radiotherapy. Int J Radiat Oncol Biol Phys. 2008 Nov 01; 72(3):633-5. PMID: 19014777.
      View in: PubMed
    28. Sun B., Baker S.E, Butler J.E, Kim H., Russell J.N, Shang L., Tse K.Y, Yang W, Hamers R.J.Covalent molecular functionalization of diamond thin-film transistors. Diamond and Related Materials. 2007; 16(8):1608-1615.
    29. Yang W, Butler JE, Russell JN, Hamers RJ. Direct electrical detection of antigen-antibody binding on diamond and silicon substrates using electrical impedance spectroscopy. Analyst. 2007 Apr; 132(4):296-306. PMID: 17554408.
      View in: PubMed
    30. Tse KY, Nichols BM, Yang W, Butler JE, Russell JN, Hamers RJ. Electrical properties of diamond surfaces functionalized with molecular monolayers. J Phys Chem B. 2005 May 05; 109(17):8523-32. PMID: 16852003.
      View in: PubMed
    31. Wensha Yang, Sarah E. Baker, James E. Bulter, Chang-soo Lee, John N. Russell, Lu Shang, Bin Sun and Robert J. Hamers.Electrically Addressable Biomolecular Functionalization of Conductive Nanocrystalline Diamond Thin Films. Chemistry of Materials. 2005; 5(17):938-940.
    32. Robert J. Hamers, James E. Butler, Tami Lasseter, Beth M. Nichols, John N. Russell Jr., Kiu-Yuen Tse, Wensha Yang.. Molecular and biomolecular monolayers on diamond as an interface to biology. Diamond and Related Materials . 2005; 14(3-7):661-668.
    33. Wensha Yang and Robert J. Hamers.. Fabrication and characterization of a biologically sensitive field-effect transistor using a nanocrystalline diamond thin film. Applied Physics Letters. 2004; 85:3626.
    34. Lee CS, Baker S, Marcus M, Yang W, Hamers RJ.Electrically Addressable Biomolecular Functionalization of Carbon Nanotube and Carbon Nanofiber Electrodes. Nano Letters. 2004; 9(4):1713-1716.
    35. Yang W, Butler JE, Russell JN, Hamers RJ. Interfacial electrical properties of DNA-modified diamond thin films: intrinsic response and hybridization-induced field effects. Langmuir. 2004 Aug 03; 20(16):6778-87. PMID: 15274585.
      View in: PubMed
    36. Lu M, Knickerbocker T, Cai W, Yang W, Hamers RJ, Smith LM. Invasive cleavage reactions on DNA-modified diamond surfaces. Biopolymers. 2004 Apr 05; 73(5):606-13. PMID: 15048784.
      View in: PubMed
    37. Yang W, Auciello O, Butler JE, Cai W, Carlisle JA, Gerbi JE, Gruen DM, Knickerbocker T, Lasseter TL, Russell JN, Smith LM, Hamers RJ. DNA-modified nanocrystalline diamond thin-films as stable, biologically active substrates. Nat Mater. 2002 Dec; 1(4):253-7. PMID: 12618788.
      View in: PubMed