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Wei Shi, MD

TitleAssociate Professor of Surgery
InstitutionUniversity of Southern California
DepartmentPediatrics
AddressCHL 4650 Sunset Blvd
Off Campus
Los Angeles CA 90027
Phone+1 323 361 5430
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    Collapse Research 
    Collapse Research Activities and Funding
    Molecular mechanisms of pulmonary disease in Birt-Hogg-Dube syndrome
    NIH/NHLBI R01HL141352Feb 1, 2018 - Jan 31, 2022
    Role: Principal Investigator
    Vascular development during lung organogenesis
    NIH/NICHD R03HD090309Jul 15, 2017 - Jun 30, 2019
    Role: Principal Investigator
    Development of a novel genetic approach to study lung mesenchymal cell signaling
    NIH/NHLBI R21HL109932Aug 1, 2011 - Jul 31, 2014
    Role: Principal Investigator
    Molecular mechanisms of lung branching morphogenesis
    NIH/NHLBI R01HL068597Jan 1, 2002 - Dec 31, 2015
    Role: Principal Investigator
    SMAD MEDIATED SIGNALING DURING LUNG MORPHOGENESIS
    NIH/NHLBI R01HL061286Aug 1, 1999 - Jul 31, 2005
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Required Scholarly Project Mentor

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Turcatel G, Millette K, Thornton M, Leguizamon S, Grubbs B, Shi W, Warburton D. Cartilage rings contribute to the proper embryonic tracheal epithelial differentiation, metabolism, and expression of inflammatory genes. Am J Physiol Lung Cell Mol Physiol. 2017 Feb 01; 312(2):L196-L207. PMID: 27941074.
      View in: PubMed
    2. Luo Y, Chen H, Ren S, Li N, Mishina Y, Shi W. BMP signaling is essential in neonatal surfactant production during respiratory adaptation. Am J Physiol Lung Cell Mol Physiol. 2016 07 01; 311(1):L29-38. PMID: 27190064.
      View in: PubMed
    3. Qian BP, Ji ML, Qiu Y, Wang B, Yu Y, Shi W, Luo YF. Identification of Serum miR-146a and miR-155 as Novel Noninvasive Complementary Biomarkers for Ankylosing Spondylitis. Spine (Phila Pa 1976). 2016 May; 41(9):735-42. PMID: 27128253.
      View in: PubMed
    4. Qian BP, Ji ML, Qiu Y, Pan T, Wang B, Mao SH, Jiang J, Shi W, Luo YF. Is There any Correlation Between Pathological Profile of Facet Joints and Clinical Feature in Patients With Thoracolumbar Kyphosis Secondary to Ankylosing Spondylitis?: An Immunohistochemical Investigation. Spine (Phila Pa 1976). 2016 May; 41(9):E512-8. PMID: 26630414.
      View in: PubMed
    5. Im D, Shi W, Driscoll B. Pediatric Acute Respiratory Distress Syndrome: Fibrosis versus Repair. Front Pediatr. 2016; 4:28. PMID: 27066462; PMCID: PMC4811965.
    6. Schumacher FR, Schmit SL, Jiao S, Edlund CK, Wang H, Zhang B, Hsu L, Huang SC, Fischer CP, Harju JF, Idos GE, Lejbkowicz F, Manion FJ, McDonnell K, McNeil CE, Melas M, Rennert HS, Shi W, Thomas DC, Van Den Berg DJ, Hutter CM, Aragaki AK, Butterbach K, Caan BJ, Carlson CS, Chanock SJ, Curtis KR, Fuchs CS, Gala M, Giovannucc EL, Giocannucci EL, Gogarten SM, Hayes RB, Henderson B, Hunter DJ, Jackson RD, Kolonel LN, Kooperberg C, Küry S, Kury S, LaCroix A, Laurie CC, Laurie CA, Lemire M, Lemire M, Levine D, Ma J, Makar KW, Qu C, Taverna D, Ulrich CM, Wu K, Kono S, West DW, Berndt SI, Bezieau S, Brenner H, Campbell PT, Chan AT, Chang-Claude J, Coetzee GA, Conti DV, Duggan D, Figueiredo JC, Fortini BK, Gallinger SJ, Gauderman WJ, Giles G, Green R, Haile R, Harrison TA, Hoffmeister M, Hopper JL, Hudson TJ, Jacobs E, Iwasaki M, Jee SH, Jenkins M, Jia WH, Joshi A, Li L, Lindor NM, Matsuo K, Moreno V, Mukherjee B, Newcomb PA, Potter JD, Raskin L, Rennert G, Rosse S, Severi G, Schoen RE, Seminara D, Shu XO, Slattery ML, Tsugane S, White E, Xiang YB, Zanke BW, Zheng W, Le Marchand L, Casey G, Gruber SB, Peters U. Genome-wide association study of colorectal cancer identifies six new susceptibility loci. Nat Commun. 2015 Jul 07; 6:7138. PMID: 26151821; PMCID: PMC4967357.
    7. Zhang W, Menke DB, Jiang M, Chen H, Warburton D, Turcatel G, Lu CH, Xu W, Luo Y, Shi W. Spatial-temporal targeting of lung-specific mesenchyme by a Tbx4 enhancer. BMC Biol. 2013 Nov 13; 11:111. PMID: 24225400; PMCID: PMC3907025.
    8. Xu W, Liu C, Kaartinen V, Chen H, Lu CH, Zhang W, Luo Y, Shi W. TACE in perinatal mouse lung epithelial cells promotes lung saccular formation. Am J Physiol Lung Cell Mol Physiol. 2013 Dec; 305(12):L953-63. PMID: 24142516; PMCID: PMC3882534.
    9. Warburton D, Shi W, Xu B. TGF-ß-Smad3 signaling in emphysema and pulmonary fibrosis: an epigenetic aberration of normal development? Am J Physiol Lung Cell Mol Physiol. 2013 Jan 15; 304(2):L83-5. PMID: 23161884; PMCID: PMC4073936.
    10. Kong N, Lan Q, Chen M, Wang J, Shi W, Horwitz DA, Quesniaux V, Ryffel B, Liu Z, Brand D, Zou H, Zheng SG. Antigen-specific transforming growth factor ß-induced Treg cells, but not natural Treg cells, ameliorate autoimmune arthritis in mice by shifting the Th17/Treg cell balance from Th17 predominance to Treg cell predominance. Arthritis Rheum. 2012 Aug; 64(8):2548-58. PMID: 22605463; PMCID: PMC4364395.
    11. Chi F, Wang L, Zheng X, Wu CH, Jong A, Sheard MA, Shi W, Huang SH. Meningitic Escherichia coli K1 penetration and neutrophil transmigration across the blood-brain barrier are modulated by alpha7 nicotinic receptor. PLoS One. 2011; 6(9):e25016. PMID: 21966399; PMCID: PMC3178609.
    12. Lu L, Ma J, Li Z, Lan Q, Chen M, Liu Y, Xia Z, Wang J, Han Y, Shi W, Quesniaux V, Ryffel B, Brand D, Li B, Liu Z, Zheng SG. All-trans retinoic acid promotes TGF-ß-induced Tregs via histone modification but not DNA demethylation on Foxp3 gene locus. PLoS One. 2011; 6(9):e24590. PMID: 21931768; PMCID: PMC3172235.
    13. Xu B, Chen C, Chen H, Zheng SG, Bringas P, Xu M, Zhou X, Chen D, Umans L, Zwijsen A, Shi W. Smad1 and its target gene Wif1 coordinate BMP and Wnt signaling activities to regulate fetal lung development. Development. 2011 Mar; 138(5):925-35. PMID: 21270055; PMCID: PMC3035095.
    14. Wilson AR, Zhou XT, Shi W, Rodin H, Bargman EP, Garrett NA, Sandberg TJ. Retail clinic versus office setting: do patients choose appropriate providers? Am J Manag Care. 2010 Oct; 16(10):753-9. PMID: 20964471.
      View in: PubMed
    15. Zhou X, Wang J, Shi W, Brand DD, Liu Z, Fan H, Zheng SG. Isolation of purified and live Foxp3+ regulatory T cells using FACS sorting on scatter plot. J Mol Cell Biol. 2010 Jun; 2(3):164-9. PMID: 20430855; PMCID: PMC2905066.
    16. Lu L, Wang J, Zhang F, Chai Y, Brand D, Wang X, Horwitz DA, Shi W, Zheng SG. Role of SMAD and non-SMAD signals in the development of Th17 and regulatory T cells. J Immunol. 2010 Apr 15; 184(8):4295-306. PMID: 20304828; PMCID: PMC3087811.
    17. Lu L, Ma J, Wang X, Wang J, Zhang F, Yu J, He G, Xu B, Brand DD, Horwitz DA, Shi W, Zheng SG. Synergistic effect of TGF-beta superfamily members on the induction of Foxp3+ Treg. Eur J Immunol. 2010 Jan; 40(1):142-52. PMID: 19943263; PMCID: PMC2837277.
    18. Shi W, Xu J, Warburton D. Development, repair and fibrosis: what is common and why it matters. Respirology. 2009 Jul; 14(5):656-65. PMID: 19659647; PMCID: PMC2747658.
    19. Carraro G, El-Hashash A, Guidolin D, Tiozzo C, Turcatel G, Young BM, De Langhe SP, Bellusci S, Shi W, Parnigotto PP, Warburton D. miR-17 family of microRNAs controls FGF10-mediated embryonic lung epithelial branching morphogenesis through MAPK14 and STAT3 regulation of E-Cadherin distribution. Dev Biol. 2009 Sep 15; 333(2):238-50. PMID: 19559694; PMCID: PMC2735610.
    20. Warburton D, Perin L, Defilippo R, Bellusci S, Shi W, Driscoll B. Stem/progenitor cells in lung development, injury repair, and regeneration. Proc Am Thorac Soc. 2008 Aug 15; 5(6):703-6. PMID: 18684721; PMCID: PMC2645263.
    21. Ding W, Shi W, Bellusci S, Groffen J, Heisterkamp N, Minoo P, Warburton D. Sprouty2 downregulation plays a pivotal role in mediating crosstalk between TGF-beta1 signaling and EGF as well as FGF receptor tyrosine kinase-ERK pathways in mesenchymal cells. J Cell Physiol. 2007 Sep; 212(3):796-806. PMID: 17516543.
      View in: PubMed
    22. Liao CP, Zhong C, Saribekyan G, Bading J, Park R, Conti PS, Moats R, Berns A, Shi W, Zhou Z, Nikitin AY, Roy-Burman P. Mouse models of prostate adenocarcinoma with the capacity to monitor spontaneous carcinogenesis by bioluminescence or fluorescence. Cancer Res. 2007 Aug 01; 67(15):7525-33. PMID: 17671224.
      View in: PubMed
    23. Warburton D, Gauldie J, Bellusci S, Shi W. Lung development and susceptibility to chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2006 Nov; 3(8):668-72. PMID: 17065371.
      View in: PubMed
    24. Raju R, Rakocevic G, Chen Z, Hoehn G, Semino-Mora C, Shi W, Olsen R, Dalakas MC. Autoimmunity to GABAA-receptor-associated protein in stiff-person syndrome. Brain. 2006 Dec; 129(Pt 12):3270-6. PMID: 16984900.
      View in: PubMed
    25. Del Moral PM, Sala FG, Tefft D, Shi W, Keshet E, Bellusci S, Warburton D. VEGF-A signaling through Flk-1 is a critical facilitator of early embryonic lung epithelial to endothelial crosstalk and branching morphogenesis. Dev Biol. 2006 Feb 01; 290(1):177-88. PMID: 16375885.
      View in: PubMed
    26. Warburton D, Shi W. Lo, and the niche is knit: lysyl oxidase activity and maintenance of lung, aorta, and skin integrity. Am J Pathol. 2005 Oct; 167(4):921-2. PMID: 16192627; PMCID: PMC1603670.
    27. Tefft D, De Langhe SP, Del Moral PM, Sala F, Shi W, Bellusci S, Warburton D. A novel function for the protein tyrosine phosphatase Shp2 during lung branching morphogenesis. Dev Biol. 2005 Jun 15; 282(2):422-31. PMID: 15950607.
      View in: PubMed
    28. Warburton D, Bellusci S, De Langhe S, Del Moral PM, Fleury V, Mailleux A, Tefft D, Unbekandt M, Wang K, Shi W. Molecular mechanisms of early lung specification and branching morphogenesis. Pediatr Res. 2005 May; 57(5 Pt 2):26R-37R. PMID: 15817505.
      View in: PubMed
    29. Chen H, Sun J, Buckley S, Chen C, Warburton D, Wang XF, Shi W. Abnormal mouse lung alveolarization caused by Smad3 deficiency is a developmental antecedent of centrilobular emphysema. Am J Physiol Lung Cell Mol Physiol. 2005 Apr; 288(4):L683-91. PMID: 15591413.
      View in: PubMed
    30. Hormi-Carver KK, Shi W, Liu CW, Berndt N. Protein phosphatase 1alpha is required for murine lung growth and morphogenesis. Dev Dyn. 2004 Apr; 229(4):791-801. PMID: 15042703.
      View in: PubMed
    31. Ding W, Bellusci S, Shi W, Warburton D. Genomic structure and promoter characterization of the human Sprouty4 gene, a novel regulator of lung morphogenesis. Am J Physiol Lung Cell Mol Physiol. 2004 Jul; 287(1):L52-9. PMID: 14977631.
      View in: PubMed
    32. Shi W, Chen H, Sun J, Chen C, Zhao J, Wang YL, Anderson KD, Warburton D. Overexpression of Smurf1 negatively regulates mouse embryonic lung branching morphogenesis by specifically reducing Smad1 and Smad5 proteins. Am J Physiol Lung Cell Mol Physiol. 2004 Feb; 286(2):L293-300. PMID: 14711801.
      View in: PubMed
    33. Ding W, Bellusci S, Shi W, Warburton D. Functional analysis of the human Sprouty2 gene promoter. Gene. 2003 Dec 11; 322:175-85. PMID: 14644509.
      View in: PubMed
    34. Shi W, Chen H, Sun J, Buckley S, Zhao J, Anderson KD, Williams RG, Warburton D. TACE is required for fetal murine cardiac development and modeling. Dev Biol. 2003 Sep 15; 261(2):371-80. PMID: 14499647.
      View in: PubMed
    35. Warburton D, Bellusci S, Del Moral PM, Kaartinen V, Lee M, Tefft D, Shi W. Growth factor signaling in lung morphogenetic centers: automaticity, stereotypy and symmetry. Respir Res. 2003; 4:5. PMID: 12818006; PMCID: PMC185249.
    36. Zhao J, Shi W, Wang YL, Chen H, Bringas P, Datto MB, Frederick JP, Wang XF, Warburton D. Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice. Am J Physiol Lung Cell Mol Physiol. 2002 Mar; 282(3):L585-93. PMID: 11839555.
      View in: PubMed