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    Vijay Kumar Kalra, PhD

    TitleProfessor of Biochemistry & Molecular Medicine
    SchoolKeck School of Medicine of USC
    DepartmentMedicine
    AddressHMR 611 2011 Zonal Avenue
    Health Sciences Campus
    Los Angeles California 90089
    Phone+1 323 442 1526
    vCardDownload vCard

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Kalra V, Zhang S, Malik P, Tahara SM. Placenta growth factor mediated gene regulation in sickle cell disease. Blood Rev. 2017 Aug 16. PMID: 28823762.
        View in: PubMed
      2. Li C, Zhou Y, Loberg A, Tahara SM, Malik P, Kalra V. Activated Transcription Factor 3 in Association with Histone Deacetylase 6 Negatively Regulates MicroRNA 199a2 Transcription by Chromatin Remodeling and Reduces Endothelin-1 Expression. Mol Cell Biol. 2016 Nov 15; 36(22):2838-2854. PMID: 27573019.
        View in: PubMed
      3. Eiymo Mwa Mpollo MS, Brandt EB, Shanmukhappa SK, Arumugam PI, Tiwari S, Loberg A, Pillis D, Rizvi T, Lindsey M, Jonck B, Carmeliet P, Kalra V, Le Cras TD, Ratner N, Wills-Karp M, Hershey GK, Malik P. Placenta growth factor augments airway hyperresponsiveness via leukotrienes and IL-13. J Clin Invest. 2016 Feb; 126(2):571-84. PMID: 26690703; PMCID: PMC4731175.
      4. Gonsalves CS, Li C, Malik P, Tahara SM, Kalra V. Peroxisome proliferator-activated receptor-a-mediated transcription of miR-301a and miR-454 and their host gene SKA2 regulates endothelin-1 and PAI-1 expression in sickle cell disease. Biosci Rep. 2015 Oct 12; 35(6). PMID: 26460070.
        View in: PubMed
      5. Gonsalves CS, Li C, Mpollo MS, Pullarkat V, Malik P, Tahara SM, Kalra V. Erythropoietin-mediated expression of placenta growth factor is regulated via activation of hypoxia-inducible factor-1a and post-transcriptionally by miR-214 in sickle cell disease. Biochem J. 2015 Jun 15; 468(3):409-23. PMID: 25876995; PMCID: PMC4643367.
      6. Li C, Gonsalves CS, Eiymo Mwa Mpollo MS, Malik P, Tahara SM, Kalra V. MicroRNA 648 Targets ET-1 mRNA and is cotranscriptionally regulated with MICAL3 by PAX5. Mol Cell Biol. 2015 Feb; 35(3):514-28. PMID: 25403488; PMCID: PMC4285416.
      7. Li C, Mpollo MS, Gonsalves CS, Tahara SM, Malik P, Kalra V. Peroxisome proliferator-activated receptor-a-mediated transcription of miR-199a2 attenuates endothelin-1 expression via hypoxia-inducible factor-1a. J Biol Chem. 2014 Dec 26; 289(52):36031-47. PMID: 25389292; PMCID: PMC4276869.
      8. Pullarkat V, Meng Z, Tahara SM, Johnson CS, Kalra V. Proteasome inhibition induces both antioxidant and hb f responses in sickle cell disease via the nrf2 pathway. Hemoglobin. 2014; 38(3):188-95. PMID: 24670032.
        View in: PubMed
      9. Gonsalves CS, Crable S, Chandra S, Li W, Kalra V, Joiner CH. Angiogenic growth factors augment K-Cl cotransporter expression in erythroid cells via hypoxia-inducible factor-1a. Am J Hematol. 2014 Mar; 89(3):273-81. PMID: 24227191; PMCID: PMC4223994.
      10. DeLeve LD, Jaeschke H, Kalra V, Asahina K, Brenner DA, Tsukamoto H. 15th International Symposium on Cells of the Hepatic Sinusoid, 2010. Liver Int. 2011 Jul; 31(6):762-72. PMID: 21645207; PMCID: PMC4388239.
      11. Patel N, Tahara SM, Malik P, Kalra V. Involvement of miR-30c and miR-301a in immediate induction of plasminogen activator inhibitor-1 by placental growth factor in human pulmonary endothelial cells. Biochem J. 2011 Mar 15; 434(3):473-82. PMID: 21175428; PMCID: PMC3078570.
      12. Gonsalves C, Kalra V. Endothelin-1-induced macrophage inflammatory protein-1beta expression in monocytic cells involves hypoxia-inducible factor-1alpha and AP-1 and is negatively regulated by microRNA-195. J Immunol. 2010 Nov 15; 185(10):6253-64. PMID: 20952681.
        View in: PubMed
      13. Yeligar SM, Machida K, Kalra V. Ethanol-induced HO-1 and NQO1 are differentially regulated by HIF-1alpha and Nrf2 to attenuate inflammatory cytokine expression. J Biol Chem. 2010 Nov 12; 285(46):35359-73. PMID: 20833713; PMCID: PMC2975160.
      14. Patel N, Kalra V. Placenta growth factor-induced early growth response 1 (Egr-1) regulates hypoxia-inducible factor-1alpha (HIF-1alpha) in endothelial cells. J Biol Chem. 2010 Jul 02; 285(27):20570-9. PMID: 20448047; PMCID: PMC2898343.
      15. Patel N, Sundaram N, Yang M, Madigan C, Kalra V, Malik P. Placenta growth factor (PlGF), a novel inducer of plasminogen activator inhibitor-1 (PAI-1) in sickle cell disease (SCD). J Biol Chem. 2010 May 28; 285(22):16713-22. PMID: 20351105; PMCID: PMC2878021.
      16. Sundaram N, Tailor A, Mendelsohn L, Wansapura J, Wang X, Higashimoto T, Pauciulo MW, Gottliebson W, Kalra V, Nichols WC, Kato GJ, Malik P. High levels of placenta growth factor in sickle cell disease promote pulmonary hypertension. Blood. 2010 Jul 08; 116(1):109-12. PMID: 20335221; PMCID: PMC2904575.
      17. Gonsalves CS, Kalra V. Hypoxia-mediated expression of 5-lipoxygenase-activating protein involves HIF-1alpha and NF-kappaB and microRNAs 135a and 199a-5p. J Immunol. 2010 Apr 01; 184(7):3878-88. PMID: 20194722.
        View in: PubMed
      18. Yeligar SM, Machida K, Tsukamoto H, Kalra V. Ethanol augments RANTES/CCL5 expression in rat liver sinusoidal endothelial cells and human endothelial cells via activation of NF-kappa B, HIF-1 alpha, and AP-1. J Immunol. 2009 Nov 01; 183(9):5964-76. PMID: 19828633; PMCID: PMC3633447.
      19. Yeligar S, Tsukamoto H, Kalra V. Ethanol-induced expression of ET-1 and ET-BR in liver sinusoidal endothelial cells and human endothelial cells involves hypoxia-inducible factor-1alpha and microrNA-199. J Immunol. 2009 Oct 15; 183(8):5232-43. PMID: 19783678; PMCID: PMC3622549.
      20. Kang J, Ramu S, Lee S, Aguilar B, Ganesan SK, Yoo J, Kalra V, Koh CJ, Hong YK. Phosphate-buffered saline-based nucleofection of primary endothelial cells. Anal Biochem. 2009 Mar 15; 386(2):251-5. PMID: 19150324; PMCID: PMC2677097.
      21. Patel N, Gonsalves CS, Yang M, Malik P, Kalra V. Placenta growth factor induces 5-lipoxygenase-activating protein to increase leukotriene formation in sickle cell disease. Blood. 2009 Jan 29; 113(5):1129-38. PMID: 18945963; PMCID: PMC2635078.
      22. Patel N, Gonsalves CS, Malik P, Kalra V. Placenta growth factor augments endothelin-1 and endothelin-B receptor expression via hypoxia-inducible factor-1 alpha. Blood. 2008 Aug 01; 112(3):856-65. PMID: 18411415; PMCID: PMC2481529.
      23. Kim KS, Rajagopal V, Gonsalves C, Johnson C, Kalra V. A novel role of hypoxia-inducible factor in cobalt chloride- and hypoxia-mediated expression of IL-8 chemokine in human endothelial cells. J Immunol. 2006 Nov 15; 177(10):7211-24. PMID: 17082639.
        View in: PubMed
      24. Niihara Y, Matsui NM, Shen YM, Akiyama DA, Johnson CS, Sunga MA, Magpayo J, Embury SH, Kalra V, Cho SH, Tanaka KR. L-glutamine therapy reduces endothelial adhesion of sickle red blood cells to human umbilical vein endothelial cells. BMC Blood Disord. 2005 Jul 25; 5:4. PMID: 16042803; PMCID: PMC1198219.
      25. Giri RK, Rajagopal V, Shahi S, Zlokovic BV, Kalra V. Mechanism of amyloid peptide induced CCR5 expression in monocytes and its inhibition by siRNA for Egr-1. Am J Physiol Cell Physiol. 2005 Aug; 289(2):C264-76. PMID: 15743889.
        View in: PubMed
      26. Giri RK, Rajagopal V, Kalra V. Curcumin, the active constituent of turmeric, inhibits amyloid peptide-induced cytochemokine gene expression and CCR5-mediated chemotaxis of THP-1 monocytes by modulating early growth response-1 transcription factor. J Neurochem. 2004 Dec; 91(5):1199-210. PMID: 15569263.
        View in: PubMed
      27. Giri RK, Selvaraj SK, Kalra V. Amyloid peptide-induced cytokine and chemokine expression in THP-1 monocytes is blocked by small inhibitory RNA duplexes for early growth response-1 messenger RNA. J Immunol. 2003 May 15; 170(10):5281-94. PMID: 12734378.
        View in: PubMed
      28. Perelman N, Selvaraj SK, Batra S, Luck LR, Erdreich-Epstein A, Coates TD, Kalra V, Malik P. Placenta growth factor activates monocytes and correlates with sickle cell disease severity. Blood. 2003 Aug 15; 102(4):1506-14. PMID: 12714517.
        View in: PubMed
      29. Selvaraj SK, Giri RK, Perelman N, Johnson C, Malik P, Kalra V. Mechanism of monocyte activation and expression of proinflammatory cytochemokines by placenta growth factor. Blood. 2003 Aug 15; 102(4):1515-24. PMID: 12689930.
        View in: PubMed
      30. Kim KJ, Matsukawa Y, Yamahara H, Kalra V, Lee VH, Crandall ED. Absorption of intact albumin across rat alveolar epithelial cell monolayers. Am J Physiol Lung Cell Mol Physiol. 2003 Mar; 284(3):L458-65. PMID: 12573985.
        View in: PubMed
      31. Giri R, Selvaraj S, Miller CA, Hofman F, Yan SD, Stern D, Zlokovic BV, Kalra V. Effect of endothelial cell polarity on beta-amyloid-induced migration of monocytes across normal and AD endothelium. Am J Physiol Cell Physiol. 2002 Sep; 283(3):C895-904. PMID: 12176746.
        View in: PubMed