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Vijay Kumar Kalra, PhD

TitleProfessor of Biochemistry & Molecular Medicine
InstitutionUniversity of Southern California
DepartmentMedicine
Phone+1 323 442 1526
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    Collapse Research 
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    PlGF-HIF1a-miRNA Axis in Sickle Pulmonary Hypertension
    NIH/NHLBI R01HL111372Jan 1, 2012 - Dec 31, 2016
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kalra VK. Aural Polyp is not Always Due to Chronic Otitis Media (COM): Preoperative Computed Tomographic Scan is Good Pointer for Sinister Lesions. Indian J Otolaryngol Head Neck Surg. 2018 Dec; 70(4):505-509. PMID: 30464906.
      View in: PubMed
    2. Kalra VK, Yadav SPS, Verma M, Singh B, Goel A. Treatment of Tympanic Membrane Retraction Pockets by Excision and Cartilage Tympanoplasty: A Prospective Study. Indian J Otolaryngol Head Neck Surg. 2018 Sep; 70(3):392-394. PMID: 30211095.
      View in: PubMed
    3. Wadhera R, Hernot S, Gulati SP, Kalra V. A controlled comparison of auditory steady-state responses and pure-tone audiometry in patients with hearing loss. Ear Nose Throat J. 2017 Oct-Nov; 96(10-11):E47-E52. PMID: 29121385.
      View in: PubMed
    4. Kalra VK, Rattan KN, Yadav SPS, Bhukar S, Dheeraj S. Second Branchial Anomalies: A Study of 94 Cases. Indian J Otolaryngol Head Neck Surg. 2017 Dec; 69(4):540-543. PMID: 29238688.
      View in: PubMed
    5. Kalra VK, Zhang S, Malik P, Tahara SM. Placenta growth factor mediated gene regulation in sickle cell disease. Blood Rev. 2018 Jan; 32(1):61-70. PMID: 28823762.
      View in: PubMed
    6. Gulati SP, Wadhera R, Khurana AK, Singh N, Kalra V, Ghai A. Results of endonasal dacryocystorhinostomy in pediatric patients. Ear Nose Throat J. 2017 Jun; 96(6):E41-E45. PMID: 28636742.
      View in: PubMed
    7. Li C, Zhou Y, Loberg A, Tahara SM, Malik P, Kalra VK. Activated Transcription Factor 3 in Association with Histone Deacetylase 6 Negatively Regulates MicroRNA 199a2 Transcription by Chromatin Remodeling and Reduces Endothelin-1 Expression. Mol Cell Biol. 2016 Nov 15; 36(22):2838-2854. PMID: 27573019.
      View in: PubMed
    8. Eiymo Mwa Mpollo MS, Brandt EB, Shanmukhappa SK, Arumugam PI, Tiwari S, Loberg A, Pillis D, Rizvi T, Lindsey M, Jonck B, Carmeliet P, Kalra VK, Le Cras TD, Ratner N, Wills-Karp M, Hershey GK, Malik P. Placenta growth factor augments airway hyperresponsiveness via leukotrienes and IL-13. J Clin Invest. 2016 Feb; 126(2):571-84. PMID: 26690703; PMCID: PMC4731175.
    9. Gonsalves CS, Li C, Malik P, Tahara SM, Kalra VK. Peroxisome proliferator-activated receptor-a-mediated transcription of miR-301a and miR-454 and their host gene SKA2 regulates endothelin-1 and PAI-1 expression in sickle cell disease. Biosci Rep. 2015 Oct 12; 35(6). PMID: 26460070.
      View in: PubMed
    10. Gonsalves CS, Li C, Mpollo MS, Pullarkat V, Malik P, Tahara SM, Kalra VK. Erythropoietin-mediated expression of placenta growth factor is regulated via activation of hypoxia-inducible factor-1a and post-transcriptionally by miR-214 in sickle cell disease. Biochem J. 2015 Jun 15; 468(3):409-23. PMID: 25876995; PMCID: PMC4643367.
    11. Li C, Gonsalves CS, Eiymo Mwa Mpollo MS, Malik P, Tahara SM, Kalra VK. MicroRNA 648 Targets ET-1 mRNA and is cotranscriptionally regulated with MICAL3 by PAX5. Mol Cell Biol. 2015 Feb; 35(3):514-28. PMID: 25403488; PMCID: PMC4285416.
    12. Li C, Mpollo MS, Gonsalves CS, Tahara SM, Malik P, Kalra VK. Peroxisome proliferator-activated receptor-a-mediated transcription of miR-199a2 attenuates endothelin-1 expression via hypoxia-inducible factor-1a. J Biol Chem. 2014 Dec 26; 289(52):36031-47. PMID: 25389292; PMCID: PMC4276869.
    13. Wadhera R, Zafar N, Gulati SP, Kalra V, Ghai A. Comparative study of intranasal septal splints and nasal packs in patients undergoing nasal septal surgery. Ear Nose Throat J. 2014 Sep; 93(9):396-408. PMID: 25255346.
      View in: PubMed
    14. Pullarkat V, Meng Z, Tahara SM, Johnson CS, Kalra VK. Proteasome inhibition induces both antioxidant and hb f responses in sickle cell disease via the nrf2 pathway. Hemoglobin. 2014; 38(3):188-95. PMID: 24670032.
      View in: PubMed
    15. Gonsalves CS, Crable S, Chandra S, Li W, Kalra VK, Joiner CH. Angiogenic growth factors augment K-Cl cotransporter expression in erythroid cells via hypoxia-inducible factor-1a. Am J Hematol. 2014 Mar; 89(3):273-81. PMID: 24227191; PMCID: PMC4223994.
    16. Wadhera R, Kalra V, Gulati SP, Ghai A. Child abuse: multiple foreign bodies in gastrointestinal tract. Int J Pediatr Otorhinolaryngol. 2013 Feb; 77(2):287-9. PMID: 23164499.
      View in: PubMed
    17. Wadhera R, Gulati SP, Kalra V, Ghai A. Migrating foreign body in the bronchus. Otolaryngol Head Neck Surg. 2011 Oct; 145(4):701-2. PMID: 21521890.
      View in: PubMed
    18. DeLeve LD, Jaeschke H, Kalra VK, Asahina K, Brenner DA, Tsukamoto H. 15th International Symposium on Cells of the Hepatic Sinusoid, 2010. Liver Int. 2011 Jul; 31(6):762-72. PMID: 21645207; PMCID: PMC4388239.
    19. Patel N, Tahara SM, Malik P, Kalra VK. Involvement of miR-30c and miR-301a in immediate induction of plasminogen activator inhibitor-1 by placental growth factor in human pulmonary endothelial cells. Biochem J. 2011 Mar 15; 434(3):473-82. PMID: 21175428; PMCID: PMC3078570.
    20. Gonsalves C, Kalra VK. Endothelin-1-induced macrophage inflammatory protein-1beta expression in monocytic cells involves hypoxia-inducible factor-1alpha and AP-1 and is negatively regulated by microRNA-195. J Immunol. 2010 Nov 15; 185(10):6253-64. PMID: 20952681.
      View in: PubMed
    21. Yeligar SM, Machida K, Kalra VK. Ethanol-induced HO-1 and NQO1 are differentially regulated by HIF-1alpha and Nrf2 to attenuate inflammatory cytokine expression. J Biol Chem. 2010 Nov 12; 285(46):35359-73. PMID: 20833713; PMCID: PMC2975160.
    22. Patel N, Kalra VK. Placenta growth factor-induced early growth response 1 (Egr-1) regulates hypoxia-inducible factor-1alpha (HIF-1alpha) in endothelial cells. J Biol Chem. 2010 Jul 02; 285(27):20570-9. PMID: 20448047; PMCID: PMC2898343.
    23. Wadhera R, Gulati SP, Kalra V, Ghai A, Garg A. A large postauricular cutaneous mastoid fistula caused by a cholesteatoma. Ear Nose Throat J. 2010 Apr; 89(4):E33-4. PMID: 20397135.
      View in: PubMed
    24. Patel N, Sundaram N, Yang M, Madigan C, Kalra VK, Malik P. Placenta growth factor (PlGF), a novel inducer of plasminogen activator inhibitor-1 (PAI-1) in sickle cell disease (SCD). J Biol Chem. 2010 May 28; 285(22):16713-22. PMID: 20351105; PMCID: PMC2878021.
    25. Sundaram N, Tailor A, Mendelsohn L, Wansapura J, Wang X, Higashimoto T, Pauciulo MW, Gottliebson W, Kalra VK, Nichols WC, Kato GJ, Malik P. High levels of placenta growth factor in sickle cell disease promote pulmonary hypertension. Blood. 2010 Jul 08; 116(1):109-12. PMID: 20335221.
      View in: PubMed
    26. Gonsalves CS, Kalra VK. Hypoxia-mediated expression of 5-lipoxygenase-activating protein involves HIF-1alpha and NF-kappaB and microRNAs 135a and 199a-5p. J Immunol. 2010 Apr 01; 184(7):3878-88. PMID: 20194722.
      View in: PubMed
    27. Yeligar SM, Machida K, Tsukamoto H, Kalra VK. Ethanol augments RANTES/CCL5 expression in rat liver sinusoidal endothelial cells and human endothelial cells via activation of NF-kappa B, HIF-1 alpha, and AP-1. J Immunol. 2009 Nov 01; 183(9):5964-76. PMID: 19828633; PMCID: PMC3633447.
    28. Yeligar S, Tsukamoto H, Kalra VK. Ethanol-induced expression of ET-1 and ET-BR in liver sinusoidal endothelial cells and human endothelial cells involves hypoxia-inducible factor-1alpha and microrNA-199. J Immunol. 2009 Oct 15; 183(8):5232-43. PMID: 19783678; PMCID: PMC3622549.
    29. Wadhera R, Gulati SP, Garg A, Ghai A, Kalra V. Clinical experience of removing dentures from aerodigestive tract. J Bronchology Interv Pulmonol. 2009 Jul; 16(3):180-2. PMID: 23168548.
      View in: PubMed
    30. Wadhera R, Gulati SP, Gupta R, Kalra V, Ghai A, Garg A. Overlooked foreign body: eighteen years inside the bronchus. J Bronchology Interv Pulmonol. 2009 Jan; 16(1):66-7. PMID: 23168476.
      View in: PubMed
    31. Kang J, Ramu S, Lee S, Aguilar B, Ganesan SK, Yoo J, Kalra VK, Koh CJ, Hong YK. Phosphate-buffered saline-based nucleofection of primary endothelial cells. Anal Biochem. 2009 Mar 15; 386(2):251-5. PMID: 19150324; PMCID: PMC2677097.
    32. Patel N, Gonsalves CS, Yang M, Malik P, Kalra VK. Placenta growth factor induces 5-lipoxygenase-activating protein to increase leukotriene formation in sickle cell disease. Blood. 2009 Jan 29; 113(5):1129-38. PMID: 18945963; PMCID: PMC2635078.
    33. Gulati SP, Chaudhry D, Kalra V, Wadhera R, Garg A. The role of functional endoscopic sinus surgery (FESS) in patients with asthma with chronic sinusitis. Indian J Otolaryngol Head Neck Surg. 2008 Jun; 60(2):152-5. PMID: 23120525; PMCID: PMC3450514.
    34. Patel N, Gonsalves CS, Malik P, Kalra VK. Placenta growth factor augments endothelin-1 and endothelin-B receptor expression via hypoxia-inducible factor-1 alpha. Blood. 2008 Aug 01; 112(3):856-65. PMID: 18411415; PMCID: PMC2481529.
    35. Kim KS, Rajagopal V, Gonsalves C, Johnson C, Kalra VK. A novel role of hypoxia-inducible factor in cobalt chloride- and hypoxia-mediated expression of IL-8 chemokine in human endothelial cells. J Immunol. 2006 Nov 15; 177(10):7211-24. PMID: 17082639.
      View in: PubMed
    36. Niihara Y, Matsui NM, Shen YM, Akiyama DA, Johnson CS, Sunga MA, Magpayo J, Embury SH, Kalra VK, Cho SH, Tanaka KR. L-glutamine therapy reduces endothelial adhesion of sickle red blood cells to human umbilical vein endothelial cells. BMC Blood Disord. 2005 Jul 25; 5:4. PMID: 16042803; PMCID: PMC1198219.
    37. Giri RK, Rajagopal V, Shahi S, Zlokovic BV, Kalra VK. Mechanism of amyloid peptide induced CCR5 expression in monocytes and its inhibition by siRNA for Egr-1. Am J Physiol Cell Physiol. 2005 Aug; 289(2):C264-76. PMID: 15743889.
      View in: PubMed
    38. Giri RK, Rajagopal V, Kalra VK. Curcumin, the active constituent of turmeric, inhibits amyloid peptide-induced cytochemokine gene expression and CCR5-mediated chemotaxis of THP-1 monocytes by modulating early growth response-1 transcription factor. J Neurochem. 2004 Dec; 91(5):1199-210. PMID: 15569263.
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    39. Giri RK, Selvaraj SK, Kalra VK. Amyloid peptide-induced cytokine and chemokine expression in THP-1 monocytes is blocked by small inhibitory RNA duplexes for early growth response-1 messenger RNA. J Immunol. 2003 May 15; 170(10):5281-94. PMID: 12734378.
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    40. Perelman N, Selvaraj SK, Batra S, Luck LR, Erdreich-Epstein A, Coates TD, Kalra VK, Malik P. Placenta growth factor activates monocytes and correlates with sickle cell disease severity. Blood. 2003 Aug 15; 102(4):1506-14. PMID: 12714517.
      View in: PubMed
    41. Selvaraj SK, Giri RK, Perelman N, Johnson C, Malik P, Kalra VK. Mechanism of monocyte activation and expression of proinflammatory cytochemokines by placenta growth factor. Blood. 2003 Aug 15; 102(4):1515-24. PMID: 12689930.
      View in: PubMed
    42. Kim KJ, Matsukawa Y, Yamahara H, Kalra VK, Lee VH, Crandall ED. Absorption of intact albumin across rat alveolar epithelial cell monolayers. Am J Physiol Lung Cell Mol Physiol. 2003 Mar; 284(3):L458-65. PMID: 12573985.
      View in: PubMed
    43. Giri R, Selvaraj S, Miller CA, Hofman F, Yan SD, Stern D, Zlokovic BV, Kalra VK. Effect of endothelial cell polarity on beta-amyloid-induced migration of monocytes across normal and AD endothelium. Am J Physiol Cell Physiol. 2002 Sep; 283(3):C895-904. PMID: 12176746.
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