Vijay Kumar Kalra, PhD

Title(s)Professor of Biochemistry & Molecular Medicine
SchoolKeck School of Medicine of Usc
AddressHMR 611, 613, 2011 Zonal Avenue
Health Sciences Campus
Los Angeles CA 90089
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    PlGF-HIF1a-miRNA Axis in Sickle Pulmonary Hypertension
    NIH R01HL111372Jan 1, 2012 - Dec 31, 2018
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Nattokinase atherothrombotic prevention study: A randomized controlled trial. Clin Hemorheol Microcirc. 2021; 78(4):339-353. Hodis HN, Mack WJ, Meiselman HJ, Kalra V, Liebman H, Hwang-Levine J, Dustin L, Kono N, Mert M, Wenby RB, Huesca E, Rochanda L, Li Y, Yan M, St John JA, Whitfield L. PMID: 33843667.
      View in: PubMed   Mentions:    Fields:    
    2. Thyroglossal Duct Remnants: A Comparison in the Presentation and Management Between Children and Adults. Indian J Otolaryngol Head Neck Surg. 2020 Jun; 72(2):184-186. Rattan KN, Kalra VK, Yadav SPS, Vashist A, Vashisth S. PMID: 32551275; PMCID: PMC7276452.
      View in: PubMed   Mentions:
    3. Aural Polyp is not Always Due to Chronic Otitis Media (COM): Preoperative Computed Tomographic Scan is Good Pointer for Sinister Lesions. Indian J Otolaryngol Head Neck Surg. 2018 Dec; 70(4):505-509. Kalra VK. PMID: 30464906; PMCID: PMC6224824.
      View in: PubMed   Mentions: 1  
    4. Treatment of Tympanic Membrane Retraction Pockets by Excision and Cartilage Tympanoplasty: A Prospective Study. Indian J Otolaryngol Head Neck Surg. 2018 Sep; 70(3):392-394. Kalra VK, Yadav SPS, Verma M, Singh B, Goel A. PMID: 30211095; PMCID: PMC6127044.
      View in: PubMed   Mentions:
    5. A controlled comparison of auditory steady-state responses and pure-tone audiometry in patients with hearing loss. Ear Nose Throat J. 2017 Oct-Nov; 96(10-11):E47-E52. Wadhera R, Hernot S, Gulati SP, Kalra V. PMID: 29121385.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    6. Second Branchial Anomalies: A Study of 94 Cases. Indian J Otolaryngol Head Neck Surg. 2017 Dec; 69(4):540-543. Kalra VK, Rattan KN, Yadav SPS, Bhukar S, Dheeraj S. PMID: 29238688; PMCID: PMC5714904.
      View in: PubMed   Mentions: 1  
    7. Placenta growth factor mediated gene regulation in sickle cell disease. Blood Rev. 2018 01; 32(1):61-70. Kalra VK, Zhang S, Malik P, Tahara SM. PMID: 28823762; PMCID: PMC5815962.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    8. Results of endonasal dacryocystorhinostomy in pediatric patients. Ear Nose Throat J. 2017 Jun; 96(6):E41-E45. Gulati SP, Wadhera R, Khurana AK, Singh N, Kalra V, Ghai A. PMID: 28636742.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    9. Activated Transcription Factor 3 in Association with Histone Deacetylase 6 Negatively Regulates MicroRNA 199a2 Transcription by Chromatin Remodeling and Reduces Endothelin-1 Expression. Mol Cell Biol. 2016 11 15; 36(22):2838-2854. Li C, Zhou Y, Loberg A, Tahara SM, Malik P, Kalra VK. PMID: 27573019; PMCID: PMC5086524.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    10. Placenta growth factor augments airway hyperresponsiveness via leukotrienes and IL-13. J Clin Invest. 2016 Feb; 126(2):571-84. Eiymo Mwa Mpollo MS, Brandt EB, Shanmukhappa SK, Arumugam PI, Tiwari S, Loberg A, Pillis D, Rizvi T, Lindsey M, Jonck B, Carmeliet P, Kalra VK, Le Cras TD, Ratner N, Wills-Karp M, Hershey GK, Malik P. PMID: 26690703; PMCID: PMC4731175.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    11. Peroxisome proliferator-activated receptor-α-mediated transcription of miR-301a and miR-454 and their host gene SKA2 regulates endothelin-1 and PAI-1 expression in sickle cell disease. Biosci Rep. 2015 Oct 12; 35(6). Gonsalves CS, Li C, Malik P, Tahara SM, Kalra VK. PMID: 26460070; PMCID: PMC4672349.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    12. Sharp 3-Ended Metallic Foreign Body in an Infant Hypopharynx. Indian J Otolaryngol Head Neck Surg. 2019 Oct; 71(Suppl 1):14-17. Hernot S, Kalra V, Wadhera R, Kaintura M. PMID: 31741920; PMCID: PMC6848338.
      View in: PubMed   Mentions:
    13. Erythropoietin-mediated expression of placenta growth factor is regulated via activation of hypoxia-inducible factor-1α and post-transcriptionally by miR-214 in sickle cell disease. Biochem J. 2015 Jun 15; 468(3):409-23. Gonsalves CS, Li C, Mpollo MS, Pullarkat V, Malik P, Tahara SM, Kalra VK. PMID: 25876995; PMCID: PMC4643367.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    14. MicroRNA 648 Targets ET-1 mRNA and is cotranscriptionally regulated with MICAL3 by PAX5. Mol Cell Biol. 2015 Feb; 35(3):514-28. Li C, Gonsalves CS, Eiymo Mwa Mpollo MS, Malik P, Tahara SM, Kalra VK. PMID: 25403488; PMCID: PMC4285416.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    15. Peroxisome proliferator-activated receptor-α-mediated transcription of miR-199a2 attenuates endothelin-1 expression via hypoxia-inducible factor-1α. J Biol Chem. 2014 Dec 26; 289(52):36031-47. Li C, Mpollo MS, Gonsalves CS, Tahara SM, Malik P, Kalra VK. PMID: 25389292; PMCID: PMC4276869.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    16. Comparative study of intranasal septal splints and nasal packs in patients undergoing nasal septal surgery. Ear Nose Throat J. 2014 Sep; 93(9):396-408. Wadhera R, Zafar N, Gulati SP, Kalra V, Ghai A. PMID: 25255346.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    17. Proteasome inhibition induces both antioxidant and hb f responses in sickle cell disease via the nrf2 pathway. Hemoglobin. 2014; 38(3):188-95. Pullarkat V, Meng Z, Tahara SM, Johnson CS, Kalra VK. PMID: 24670032.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCellsCTClinical Trials
    18. Angiogenic growth factors augment K-Cl cotransporter expression in erythroid cells via hypoxia-inducible factor-1α. Am J Hematol. 2014 Mar; 89(3):273-81. Gonsalves CS, Crable S, Chandra S, Li W, Kalra VK, Joiner CH. PMID: 24227191; PMCID: PMC4223994.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    19. Child abuse: multiple foreign bodies in gastrointestinal tract. Int J Pediatr Otorhinolaryngol. 2013 Feb; 77(2):287-9. Wadhera R, Kalra V, Gulati SP, Ghai A. PMID: 23164499.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    20. Migrating foreign body in the bronchus. Otolaryngol Head Neck Surg. 2011 Oct; 145(4):701-2. Wadhera R, Gulati SP, Kalra V, Ghai A. PMID: 21521890.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    21. 15th International Symposium on Cells of the Hepatic Sinusoid, 2010. Liver Int. 2011 Jul; 31(6):762-72. DeLeve LD, Jaeschke H, Kalra VK, Asahina K, Brenner DA, Tsukamoto H. PMID: 21645207; PMCID: PMC4388239.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    22. Involvement of miR-30c and miR-301a in immediate induction of plasminogen activator inhibitor-1 by placental growth factor in human pulmonary endothelial cells. Biochem J. 2011 Mar 15; 434(3):473-82. Patel N, Tahara SM, Malik P, Kalra VK. PMID: 21175428; PMCID: PMC3078570.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    23. Endothelin-1-induced macrophage inflammatory protein-1beta expression in monocytic cells involves hypoxia-inducible factor-1alpha and AP-1 and is negatively regulated by microRNA-195. J Immunol. 2010 Nov 15; 185(10):6253-64. Gonsalves C, Kalra VK. PMID: 20952681.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    24. Ethanol-induced HO-1 and NQO1 are differentially regulated by HIF-1alpha and Nrf2 to attenuate inflammatory cytokine expression. J Biol Chem. 2010 Nov 12; 285(46):35359-73. Yeligar SM, Machida K, Kalra VK. PMID: 20833713; PMCID: PMC2975160.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    25. Placenta growth factor-induced early growth response 1 (Egr-1) regulates hypoxia-inducible factor-1alpha (HIF-1alpha) in endothelial cells. J Biol Chem. 2010 Jul 02; 285(27):20570-9. Patel N, Kalra VK. PMID: 20448047; PMCID: PMC2898343.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    26. A large postauricular cutaneous mastoid fistula caused by a cholesteatoma. Ear Nose Throat J. 2010 Apr; 89(4):E33-4. Wadhera R, Gulati SP, Kalra V, Ghai A, Garg A. PMID: 20397135.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    27. Placenta growth factor (PlGF), a novel inducer of plasminogen activator inhibitor-1 (PAI-1) in sickle cell disease (SCD). J Biol Chem. 2010 May 28; 285(22):16713-22. Patel N, Sundaram N, Yang M, Madigan C, Kalra VK, Malik P. PMID: 20351105; PMCID: PMC2878021.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    28. High levels of placenta growth factor in sickle cell disease promote pulmonary hypertension. Blood. 2010 Jul 08; 116(1):109-12. Sundaram N, Tailor A, Mendelsohn L, Wansapura J, Wang X, Higashimoto T, Pauciulo MW, Gottliebson W, Kalra VK, Nichols WC, Kato GJ, Malik P. PMID: 20335221; PMCID: PMC2904575.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    29. Hypoxia-mediated expression of 5-lipoxygenase-activating protein involves HIF-1alpha and NF-kappaB and microRNAs 135a and 199a-5p. J Immunol. 2010 Apr 01; 184(7):3878-88. Gonsalves CS, Kalra VK. PMID: 20194722.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    30. Ethanol augments RANTES/CCL5 expression in rat liver sinusoidal endothelial cells and human endothelial cells via activation of NF-kappa B, HIF-1 alpha, and AP-1. J Immunol. 2009 Nov 01; 183(9):5964-76. Yeligar SM, Machida K, Tsukamoto H, Kalra VK. PMID: 19828633; PMCID: PMC3633447.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    31. Ethanol-induced expression of ET-1 and ET-BR in liver sinusoidal endothelial cells and human endothelial cells involves hypoxia-inducible factor-1alpha and microrNA-199. J Immunol. 2009 Oct 15; 183(8):5232-43. Yeligar S, Tsukamoto H, Kalra VK. PMID: 19783678; PMCID: PMC3622549.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    32. Clinical experience of removing dentures from aerodigestive tract. J Bronchology Interv Pulmonol. 2009 Jul; 16(3):180-2. Wadhera R, Gulati SP, Garg A, Ghai A, Kalra V. PMID: 23168548.
      View in: PubMed   Mentions: 1     Fields:    
    33. Overlooked foreign body: eighteen years inside the bronchus. J Bronchology Interv Pulmonol. 2009 Jan; 16(1):66-7. Wadhera R, Gulati SP, Gupta R, Kalra V, Ghai A, Garg A. PMID: 23168476.
      View in: PubMed   Mentions:    Fields:    
    34. Phosphate-buffered saline-based nucleofection of primary endothelial cells. Anal Biochem. 2009 Mar 15; 386(2):251-5. Kang J, Ramu S, Lee S, Aguilar B, Ganesan SK, Yoo J, Kalra VK, Koh CJ, Hong YK. PMID: 19150324; PMCID: PMC2677097.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    35. Placenta growth factor induces 5-lipoxygenase-activating protein to increase leukotriene formation in sickle cell disease. Blood. 2009 Jan 29; 113(5):1129-38. Patel N, Gonsalves CS, Yang M, Malik P, Kalra VK. PMID: 18945963; PMCID: PMC2635078.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    36. The role of functional endoscopic sinus surgery (FESS) in patients with asthma with chronic sinusitis. Indian J Otolaryngol Head Neck Surg. 2008 Jun; 60(2):152-5. Gulati SP, Chaudhry D, Kalra V, Wadhera R, Garg A. PMID: 23120525; PMCID: PMC3450514.
      View in: PubMed   Mentions: 2  
    37. Placenta growth factor augments endothelin-1 and endothelin-B receptor expression via hypoxia-inducible factor-1 alpha. Blood. 2008 Aug 01; 112(3):856-65. Patel N, Gonsalves CS, Malik P, Kalra VK. PMID: 18411415; PMCID: PMC2481529.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    38. A novel role of hypoxia-inducible factor in cobalt chloride- and hypoxia-mediated expression of IL-8 chemokine in human endothelial cells. J Immunol. 2006 Nov 15; 177(10):7211-24. Kim KS, Rajagopal V, Gonsalves C, Johnson C, Kalra VK. PMID: 17082639.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansCells
    39. L-glutamine therapy reduces endothelial adhesion of sickle red blood cells to human umbilical vein endothelial cells. BMC Blood Disord. 2005 Jul 25; 5:4. Niihara Y, Matsui NM, Shen YM, Akiyama DA, Johnson CS, Sunga MA, Magpayo J, Embury SH, Kalra VK, Cho SH, Tanaka KR. PMID: 16042803; PMCID: PMC1198219.
      View in: PubMed   Mentions: 20  
    40. Mechanism of amyloid peptide induced CCR5 expression in monocytes and its inhibition by siRNA for Egr-1. Am J Physiol Cell Physiol. 2005 Aug; 289(2):C264-76. Giri RK, Rajagopal V, Shahi S, Zlokovic BV, Kalra VK. PMID: 15743889.
      View in: PubMed   Mentions: 10  Translation:HumansCells
    41. Curcumin, the active constituent of turmeric, inhibits amyloid peptide-induced cytochemokine gene expression and CCR5-mediated chemotaxis of THP-1 monocytes by modulating early growth response-1 transcription factor. J Neurochem. 2004 Dec; 91(5):1199-210. Giri RK, Rajagopal V, Kalra VK. PMID: 15569263.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    42. Amyloid peptide-induced cytokine and chemokine expression in THP-1 monocytes is blocked by small inhibitory RNA duplexes for early growth response-1 messenger RNA. J Immunol. 2003 May 15; 170(10):5281-94. Giri RK, Selvaraj SK, Kalra VK. PMID: 12734378.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    43. Placenta growth factor activates monocytes and correlates with sickle cell disease severity. Blood. 2003 Aug 15; 102(4):1506-14. Perelman N, Selvaraj SK, Batra S, Luck LR, Erdreich-Epstein A, Coates TD, Kalra VK, Malik P. PMID: 12714517.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    44. Mechanism of monocyte activation and expression of proinflammatory cytochemokines by placenta growth factor. Blood. 2003 Aug 15; 102(4):1515-24. Selvaraj SK, Giri RK, Perelman N, Johnson C, Malik P, Kalra VK. PMID: 12689930.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansCells
    45. Absorption of intact albumin across rat alveolar epithelial cell monolayers. Am J Physiol Lung Cell Mol Physiol. 2003 Mar; 284(3):L458-65. Kim KJ, Matsukawa Y, Yamahara H, Kalra VK, Lee VH, Crandall ED. PMID: 12573985.
      View in: PubMed   Mentions: 7  Translation:AnimalsCells
    46. Effect of endothelial cell polarity on beta-amyloid-induced migration of monocytes across normal and AD endothelium. Am J Physiol Cell Physiol. 2002 Sep; 283(3):C895-904. Giri R, Selvaraj S, Miller CA, Hofman F, Yan SD, Stern D, Zlokovic BV, Kalra VK. PMID: 12176746.
      View in: PubMed   Mentions: 27  Translation:HumansCells
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