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    Venkatesh Natarajan, PhD

    TitleAssistant Professor of Research Medicine
    SchoolKeck School of Medicine of USC
    DepartmentMedicine
    AddressNOR 1441 Eastlake Ave
    Health Sciences Campus
    Los Angeles California 90033
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      Collapse Overview 
      Collapse Overview
      Dr. Natarajan's major areas of research interest include cancer biology, functional genomic screens, drug discovery, biologics development and targeted therapy. His current research involves performing a functional genetic screen, combining bar-coded lentiviral shRNA library with HT-sequencing to identify modulators of TLR5 signaling. This study identified several candidates which differentially affect NF-kB activation by IL1, TNF and flagellin.

      Dr. Natarajan earned his Masters in Biotechnology at The Indian Institute of Technology. He then went on to complete his PhD in Bioechemistry, followed by three research fellowships; the first at The Weizmann Institute of Science, the second at Harvard Medical School, and the third at The Council of Scientific and Industrial Research.


      Collapse Biography 
      Collapse Awards and Honors
      India1989 - 1992National Merit Scholarship
      India1992 - 1994National Scholarship from Department of Biotechnology

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      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Natarajan V, Komarov AP, Ippolito T, Bonneau K, Chenchik AA, Gudkov AV. Peptides genetically selected for NF-?B activation cooperate with oncogene Ras and model carcinogenic role of inflammation. Proc Natl Acad Sci U S A. 2014 Jan 28; 111(4):E474-83. PMID: 24474797.
        View in: PubMed
      2. Mannava S, Moparthy KC, Wheeler LJ, Natarajan V, Zucker SN, Fink EE, Im M, Flanagan S, Burhans WC, Zeitouni NC, Shewach DS, Mathews CK, Nikiforov MA. Depletion of deoxyribonucleotide pools is an endogenous source of DNA damage in cells undergoing oncogene-induced senescence. Am J Pathol. 2013 Jan; 182(1):142-51. PMID: 23245831.
        View in: PubMed
      3. Berman AE, Leontieva OV, Natarajan V, McCubrey JA, Demidenko ZN, Nikiforov MA. Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes. Oncotarget. 2012 Dec; 3(12):1522-32. PMID: 23455653.
        View in: PubMed
      4. Leontieva OV, Natarajan V, Demidenko ZN, Burdelya LG, Gudkov AV, Blagosklonny MV. Hypoxia suppresses conversion from proliferative arrest to cellular senescence. Proc Natl Acad Sci U S A. 2012 Aug 14; 109(33):13314-8. PMID: 22847439.
        View in: PubMed
      5. Yoon SI, Kurnasov O, Natarajan V, Hong M, Gudkov AV, Osterman AL, Wilson IA. Structural basis of TLR5-flagellin recognition and signaling. Science. 2012 Feb 17; 335(6070):859-64. PMID: 22344444.
        View in: PubMed
      6. Venkatesh N, Feng Y, DeDecker B, Yacono P, Golan D, Mitchison T, McKeon F. Chemical genetics to identify NFAT inhibitors: potential of targeting calcium mobilization in immunosuppression. Proc Natl Acad Sci U S A. 2004 Jun 15; 101(24):8969-74. PMID: 15184684.
        View in: PubMed
      7. Kasher R, Gayer B, Kulik T, Somjen D, Venkatesh N, Fridkin M, Katchalski-Katzir E, Kohen F. Design, synthesis, and evaluation of peptides with estrogen-like activity. Biopolymers. 2004; 76(5):404-20. PMID: 15468062.
        View in: PubMed
      8. Im SH, Kim SH, Azam T, Venkatesh N, Dinarello CA, Fuchs S, Souroujon MC. Rat interleukin-18 binding protein: cloning, expression, and characterization. J Interferon Cytokine Res. 2002 Mar; 22(3):321-8. PMID: 12034039.
        View in: PubMed
      9. Venkatesh N, Zaltsman Y, Somjen D, Gayer B, Boopathi E, Kasher R, Kulik T, Katchalski-Katzir E, Kohen F. A synthetic peptide with estrogen-like activity derived from a phage-display peptide library. Peptides. 2002 Mar; 23(3):573-80. PMID: 11836009.
        View in: PubMed
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