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Unmesh Jadhav

Photo of Unmesh Jadhav
Title(s)Assistant Professor of Stem Cell Biology and Regenerative Medicine
SchoolKeck School of Medicine of Usc
Address1425 San Pablo St.
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 2563
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    Collapse Research 
    Collapse research activities and funding
    High resolution characterization of epigenetic dynamics in gastrointestinal cell plasticity
    NIH R03DK134799Feb 1, 2023 - Jan 31, 2025
    Role: Principal Investigator
    Coordinate roles of histone H3K27me3 and DNA methylation in intestinal homeostasis and tumorigenesis
    NIH K01DK113067Jan 1, 2018 - Nov 30, 2022
    Role: Principal Investigator
    Role of histone H3K27me3 mark in intestinal homeostasis
    NIH F32DK103453Jul 1, 2014 - Jun 30, 2017
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Epigenetic Gatekeeping of Intestinal Stem Cell Transformation. bioRxiv. 2026 Feb 03. Lorzadeh A, Sharma S, Ye G, Rabaya S, Kang YJ, Shivdasani RA, Jadhav U. PMID: 41676680; PMCID: PMC12889513.
      View in: PubMed   Mentions:
    2. A niche-dependent redox rheostat regulates epithelial stem cell fate. Nat Commun. 2025 Nov 28; 16(1):11713. Chen X, Raghunathan K, Bao B, Ngwa E, Kwong A, Wu Z, Babcock S, Baek C, Ye G, Muppirala A, Peng Q, Rutlin M, Bhaumik M, Yang D, Kotlarz D, Jadhav U, Rao M, Weerapana E, Zhou X, Ordovas-Montanes J, Snapper SB, Thiagarajah JR. PMID: 41315209; PMCID: PMC12754055.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Motif distribution and DNA methylation underlie distinct Cdx2 binding during development and homeostasis. Nat Commun. 2025 Jan 22; 16(1):929. Lorzadeh A, Ye G, Sharma S, Jadhav U. PMID: 39843425; PMCID: PMC11754732.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    4. Crypt density and recruited enhancers underlie intestinal tumour initiation. Nature. 2025 04; 640(8057):231-239. Gaynor L, Singh H, Tie G, Badarinath K, Madha S, Mancini A, Bhattacharya S, Hoshino M, de Sauvage FJ, Murata K, Jadhav U, Shivdasani RA. PMID: 39778708; PMCID: PMC12166968.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    5. DNA methylation-dependent and -independent binding of CDX2 directs activation of distinct developmental and homeostatic genes. bioRxiv. 2024 Mar 07. Lorzadeh A, Ye G, Sharma S, Jadhav U. PMID: 38405700; PMCID: PMC10888781.
      View in: PubMed   Mentions:
    6. Ornithine aminotransferase supports polyamine synthesis in pancreatic cancer. Nature. 2023 04; 616(7956):339-347. Lee MS, Dennis C, Naqvi I, Dailey L, Lorzadeh A, Ye G, Zaytouni T, Adler A, Hitchcock DS, Lin L, Hoffman MT, Bhuiyan AM, Barth JL, Machacek ME, Mino-Kenudson M, Dougan SK, Jadhav U, Clish CB, Kalaany NY. PMID: 36991126; PMCID: PMC10929664.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimals
    7. Epigenetic Regulation of Intestinal Stem Cells and Disease: A Balancing Act of DNA and Histone Methylation. Gastroenterology. 2021 06; 160(7):2267-2282. Lorzadeh A, Romero-Wolf M, Goel A, Jadhav U. PMID: 33775639; PMCID: PMC8169626.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    8. Creb5 establishes the competence for Prg4 expression in articular cartilage. Commun Biol. 2021 03 12; 4(1):332. Zhang CH, Gao Y, Jadhav U, Hung HH, Holton KM, Grodzinsky AJ, Shivdasani RA, Lassar AB. PMID: 33712729; PMCID: PMC7955038.
      View in: PubMed   Mentions: 34  Translation:AnimalsCells
    9. Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1. Proc Natl Acad Sci U S A. 2021 03 09; 118(10). Tsai PY, Lee MS, Jadhav U, Naqvi I, Madha S, Adler A, Mistry M, Naumenko S, Lewis CA, Hitchcock DS, Roberts FR, DelNero P, Hank T, Honselmann KC, Morales Oyarvide V, Mino-Kenudson M, Clish CB, Shivdasani RA, Kalaany NY. PMID: 33653947; PMCID: PMC7958225.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    10. Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells. Cell Stem Cell. 2020 03 05; 26(3):377-390.e6. Murata K, Jadhav U, Madha S, van Es J, Dean J, Cavazza A, Wucherpfennig K, Michor F, Clevers H, Shivdasani RA. PMID: 32084390; PMCID: PMC7147146.
      View in: PubMed   Mentions: 140     Fields:    Translation:Cells
    11. Replicational Dilution of H3K27me3 in Mammalian Cells and the Role of Poised Promoters. Mol Cell. 2020 04 02; 78(1):141-151.e5. Jadhav U, Manieri E, Nalapareddy K, Madha S, Chakrabarti S, Wucherpfennig K, Barefoot M, Shivdasani RA. PMID: 32027840; PMCID: PMC7376365.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    12. Extensive Recovery of Embryonic Enhancer and Gene Memory Stored in Hypomethylated Enhancer DNA. Mol Cell. 2019 05 02; 74(3):542-554.e5. Jadhav U, Cavazza A, Banerjee KK, Xie H, O'Neill NK, Saenz-Vash V, Herbert Z, Madha S, Orkin SH, Zhai H, Shivdasani RA. PMID: 30905509; PMCID: PMC6499659.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    13. Dissecting Cell Lineages: From Microscope to Kaleidoscope. Cell. 2019 02 21; 176(5):949-951. Jadhav U, Shivdasani RA. PMID: 30794779.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    14. Enhancer, transcriptional, and cell fate plasticity precedes intestinal determination during endoderm development. Genes Dev. 2018 11 01; 32(21-22):1430-1442. Banerjee KK, Saxena M, Kumar N, Chen L, Cavazza A, Toke NH, O'Neill NK, Madha S, Jadhav U, Verzi MP, Shivdasani RA. PMID: 30366903; PMCID: PMC6217732.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    15. RORα-expressing T regulatory cells restrain allergic skin inflammation. Sci Immunol. 2018 03 02; 3(21). Malhotra N, Leyva-Castillo JM, Jadhav U, Barreiro O, Kam C, O'Neill NK, Meylan F, Chambon P, von Andrian UH, Siegel RM, Wang EC, Shivdasani R, Geha RS. PMID: 29500225; PMCID: PMC5912895.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    16. Transcription factor-dependent 'anti-repressive' mammalian enhancers exclude H3K27me3 from extended genomic domains. Genes Dev. 2017 12 01; 31(23-24):2391-2404. Saxena M, Roman AKS, O'Neill NK, Sulahian R, Jadhav U, Shivdasani RA. PMID: 29321178; PMCID: PMC5795785.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    17. Dynamic Reorganization of Chromatin Accessibility Signatures during Dedifferentiation of Secretory Precursors into Lgr5+ Intestinal Stem Cells. Cell Stem Cell. 2017 07 06; 21(1):65-77.e5. Jadhav U, Saxena M, O'Neill NK, Saadatpour A, Yuan GC, Herbert Z, Murata K, Shivdasani RA. PMID: 28648363; PMCID: PMC5505276.
      View in: PubMed   Mentions: 152     Fields:    Translation:AnimalsCells
    18. Natural Selection, Crypt Fitness, and Pol III Dependency in the Intestine. Cell Mol Gastroenterol Hepatol. 2016 Nov; 2(6):714-715. Jadhav U, Shivdasani RA. PMID: 28174745; PMCID: PMC5247341.
      View in: PubMed   Mentions:    Fields:    
    19. Single-Cell Transcript Profiles Reveal Multilineage Priming in Early Progenitors Derived from Lgr5(+) Intestinal Stem Cells. Cell Rep. 2016 08 23; 16(8):2053-2060. Kim TH, Saadatpour A, Guo G, Saxena M, Cavazza A, Desai N, Jadhav U, Jiang L, Rivera MN, Orkin SH, Yuan GC, Shivdasani RA. PMID: 27524622; PMCID: PMC5001892.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    20. Acquired Tissue-Specific Promoter Bivalency Is a Basis for PRC2 Necessity in Adult Cells. Cell. 2016 Jun 02; 165(6):1389-1400. Jadhav U, Nalapareddy K, Saxena M, O'Neill NK, Pinello L, Yuan GC, Orkin SH, Shivdasani RA. PMID: 27212235; PMCID: PMC4893000.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    21. SOX15 governs transcription in human stratified epithelia and a subset of esophageal adenocarcinomas. Cell Mol Gastroenterol Hepatol. 2015 Nov 01; 1(6):598-609.e6. Sulahian R, Chen J, Arany Z, Jadhav U, Peng S, Rustgi AK, Bass AJ, Srivastava A, Hornick JL, Shivdasani RA. PMID: 26516633; PMCID: PMC4620585.
      View in: PubMed   Mentions: 9     Fields:    
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    NIH Funding Acknowledgment: Important - All publications resulting from the utilization of SC CTSI resources are required to credit the SC CTSI grant by including the NIH funding acknowledgment and must comply with the NIH Public Access Policy.

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