Troy A. McEachron

Title(s)Assistant Professor Of Research Translational Genomics
Address1450 Biggy St.
Health Sciences Campus
Los Angeles CA 90089-9601
Phone+1 323 442 6049
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    Collapse Biography 
    Collapse Awards and Honors
    Translational Genomics Research Institute (TGen)2014Honorary Delegate, Society for Adolescent and Young Adult Oncology Annual Meeting
    Translational Genomics Research Institute (TGen)2012  - 2014UNCF/Merck Postdoctoral Science Research Fellowship
    University of North Carolina at Chapel Hill2009  - 2011Ruth L. Kirschstein National Research Service Award for Individual Pre-Doctoral Fellowships (F31)
    University of North Carolina at Chapel Hill2008Carl Storm Minority Fellowship Award
    University of North Carolina at Chapel Hill2009AACR Minority Scholar in Cancer Research

    Collapse Overview 
    Collapse Overview
    My research focuses on two separate yet complimentary areas: (1) the utilization of next generation genomic, transcriptomic, and proteomic technologies to profile recurrent and/or refractory pediatric, adolescent, and young adult (AYA) cancer patients for clinical decision making; (2) the use of functional genomics to identify and interrogate the developmental and therapeutic aspects of sarcomas that predominantly arise in the pediatric and AYA populations. My overall research interests are a reflection of my diverse training history. My training background in basic science includes the molecular dissection of autocrine and paracrine signaling mechanisms between tumor and host using in vitro and in vivo models and the characterization of genetically engineered mouse models of pediatric brain tumors. Additionally, my translational science training includes the interpretation and functional validation next generation sequencing data from recurrent/refractory pediatric cancer patients.

    Over time I have gained an immense interest in rhabdomyosarcomas (RMS), desmoplastic small round cell tumors (DSRCT), Ewing sarcomas (EWS), and clear cell sarcomas (CCS). The relatively low mutation burden in numerous different types of sarcomas suggests that there are transcriptional and/or epigenetic mechanisms that drive these diseases. This is inline with recent studies suggesting that epigenetic dysregulation and altered developmental programing drive many pediatric malignancies. Moreover, the mechanisms by which sarcoma-specific oncogenic fusion genes initiate and/or sustain disease remains elusive. My laboratory is dedicated to developing new biological tools and approaches to enable a functional genomics inquiry into these mechanisms as to reveal insight into the underlying biology of these sarcomas. Additionally, we will interrogate patient derived material to better define the molecular characteristics of different sarcoma subtypes to enable more precise treatment strategies for these difficult diseases.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Transcriptome analysis of desmoplastic small round cell tumors identifies actionable therapeutic targets: a report from the Children's Oncology Group. Sci Rep. 2020 Jul 23; 10(1):12318. Hingorani P, Dinu V, Zhang X, Lei H, Shern JF, Park J, Steel J, Rauf F, Parham D, Gastier-Foster J, Hall D, Hawkins DS, Skapek SX, Labaer J, McEachron TA. PMID: 32703985.
      View in: PubMed   Mentions:    Fields:    
    2. Targeted transcriptional profiling of the tumor microenvironment reveals lymphocyte exclusion and vascular dysfunction in metastatic osteosarcoma. Oncoimmunology. 2019; 8(9):e1629779. Sorenson L, Fu Y, Hood T, Warren S, McEachron TA. PMID: 31428529.
      View in: PubMed   Mentions:
    3. Profiling targetable immune checkpoints in osteosarcoma. Oncoimmunology. 2018; 7(12):e1475873. McEachron TA, Triche TJ, Sorenson L, Parham DM, Carpten JD. PMID: 30524885.
      View in: PubMed   Mentions:
    4. Molecular Genetic Profiling of Adolescent Glassy Cell Carcinoma of the Cervix Reveals Targetable EGFR Amplification with Potential Therapeutic Implications. J Adolesc Young Adult Oncol. 2016 09; 5(3):297-302. McEachron TA, Sender LS, Zabokrtsky KB, Kaltenecker B, Holmes WN, Cherni I, Manojlovic Z, Liao SY, Craig DW, Carpten JD, Torno LR. PMID: 26974246.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Successful Treatment of Genetically Profiled Pediatric Extranodal NK/T-Cell Lymphoma Targeting Oncogenic STAT3 Mutation. Pediatr Blood Cancer. 2016 Apr; 63(4):727-30. McEachron TA, Kirov I, Wungwattana M, Cortes D, Zabokrtsky KB, Sassoon A, Craig D, Carpten JD, Sender LS. PMID: 26727971.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Histone H3 mutations in pediatric brain tumors. Cold Spring Harb Perspect Biol. 2014 Apr 01; 6(4):a018689. Liu X, McEachron TA, Schwartzentruber J, Wu G. PMID: 24691963.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    7. Small cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4. Nat Genet. 2014 May; 46(5):427-9. Ramos P, Karnezis AN, Craig DW, Sekulic A, Russell ML, Hendricks WP, Corneveaux JJ, Barrett MT, Shumansky K, Yang Y, Shah SP, Prentice LM, Marra MA, Kiefer J, Zismann VL, McEachron TA, Salhia B, Prat J, D'Angelo E, Clarke BA, Pressey JG, Farley JH, Anthony SP, Roden RB, Cunliffe HE, Huntsman DG, Trent JM. PMID: 24658001.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    8. An integrated approach to identifying clinically relevant targets in pediatric gliomas. CNS Oncol. 2013 Jul; 2(4):303-6. McEachron TA, Tomboc P, Tran NL. PMID: 25054574.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. PF4/heparin-antibody complex induces monocyte tissue factor expression and release of tissue factor positive microparticles by activation of Fc?RI. Blood. 2012 May 31; 119(22):5285-93. Kasthuri RS, Glover SL, Jonas W, McEachron T, Pawlinski R, Arepally GM, Key NS, Mackman N. PMID: 22394597.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCellsCTClinical Trials
    10. Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas. Nat Genet. 2012 Jan 29; 44(3):251-3. Wu G, Broniscer A, McEachron TA, Lu C, Paugh BS, Becksfort J, Qu C, Ding L, Huether R, Parker M, Zhang J, Gajjar A, Dyer MA, Mullighan CG, Gilbertson RJ, Mardis ER, Wilson RK, Downing JR, Ellison DW, Zhang J, Baker SJ. PMID: 22286216.
      View in: PubMed   Mentions: 453     Fields:    Translation:HumansCells
    11. Regulation of thrombin-induced plasminogen activator inhibitor-1 in 4T1 murine breast cancer cells. Blood Coagul Fibrinolysis. 2011 Oct; 22(7):576-82. McEachron TA, Church FC, Mackman N. PMID: 21799402.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    12. Protease-activated receptors mediate crosstalk between coagulation and fibrinolysis. Blood. 2010 Dec 02; 116(23):5037-44. McEachron TA, Pawlinski R, Richards KL, Church FC, Mackman N. PMID: 20736455.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    13. Tumors, ticks and tissue factor. J Thromb Haemost. 2009 Nov; 7(11):1852-4. McEachron T, Mackman N. PMID: 19694942.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells