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    Toshio Miki, PhD

    TitleAssistant Professor of Research Surgery
    SchoolKeck School of Medicine of USC
    DepartmentSurgery
    AddressHMR 509A 2011 Zonal Ave
    Health Sciences Campus
    Los Angeles California 90033-9141
    Phone+1 323 442 7703
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      Toshio Miki, Assistant Professor at the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at University of Southern California, received his MD and PhD from Nihon University School of Medicine, Tokyo, Japan. Prior to his move to USC, Miki had conducted various medical research projects at the University of Pittsburgh, Pennsylvania. In 2005, he discovered stem cell-like cell populations in the human amnion and, since then, Miki is best known for his studies of placental stem cells and clinical applications. He has authored more than 30 scientific articles, books and chapters.


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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Shao Y, Taniguchi K, Townshend RF, Miki T, Gumucio DL, Fu J. A pluripotent stem cell-based model for post-implantation human amniotic sac development. Nat Commun. 2017 Aug 08; 8(1):208. PMID: 28785084.
        View in: PubMed
      2. Rodriguez NS, Yanuaria L, Parducho KMR, Garcia IM, Varghese BA, Grubbs BH, Miki T. Liver-Directed Human Amniotic Epithelial Cell Transplantation Improves Systemic Disease Phenotype in Hurler Syndrome Mouse Model. Stem Cells Transl Med. 2017 Jul; 6(7):1583-1594. PMID: 28585336.
        View in: PubMed
      3. Sakiyama R, Blau BJ, Miki T. Clinical translation of bioartificial liver support systems with human pluripotent stem cell-derived hepatic cells. World J Gastroenterol. 2017 Mar 21; 23(11):1974-1979. PMID: 28373763.
        View in: PubMed
      4. Miki T. A Rational Strategy for the Use of Amniotic Epithelial Stem Cell Therapy for Liver Diseases. Stem Cells Transl Med. 2016 Apr; 5(4):405-9. PMID: 26941361; PMCID: PMC4798744 [Available on 04/01/17].
      5. Miki T, Wong W, Zhou E, Gonzalez A, Garcia I, Grubbs BH. Biological impact of xeno-free chemically defined cryopreservation medium on amniotic epithelial cells. Stem Cell Res Ther. 2016 Jan 12; 7:8. PMID: 26758986; PMCID: PMC4711023.
      6. Moeini A, Machida H, Takiuchi T, Blake EA, Hom MS, Miki T, Matsuo O, Matsuo K. Association of Nonalcoholic Fatty Liver Disease and Venous Thromboembolism in Women With Endometrial Cancer. Clin Appl Thromb Hemost. 2016 Jan 01; 1076029616665925. PMID: 27582024.
        View in: PubMed
      7. Strom SC, Skvorak K, Gramignoli R, Marongiu F, Miki T. Translation of amnion stem cells to the clinic. Stem Cells Dev. 2013 Dec; 22 Suppl 1:96-102. PMID: 24304085.
        View in: PubMed
      8. Miki T, Grubbs B. Therapeutic potential of placenta-derived stem cells for liver diseases: current status and perspectives. J Obstet Gynaecol Res. 2014 Feb; 40(2):360-8. PMID: 24245961.
        View in: PubMed
      9. D'Aiuto L, Di Maio R, Heath B, Raimondi G, Milosevic J, Watson AM, Bamne M, Parks WT, Yang L, Lin B, Miki T, Mich-Basso JD, Arav-Boger R, Sibille E, Sabunciyan S, Yolken R, Nimgaonkar V. Human induced pluripotent stem cell-derived models to investigate human cytomegalovirus infection in neural cells. PLoS One. 2012; 7(11):e49700. PMID: 23209593; PMCID: PMC3507916.
      10. Easley CA, Phillips BT, McGuire MM, Barringer JM, Valli H, Hermann BP, Simerly CR, Rajkovic A, Miki T, Orwig KE, Schatten GP. Direct differentiation of human pluripotent stem cells into haploid spermatogenic cells. Cell Rep. 2012 Sep 27; 2(3):440-6. PMID: 22921399; PMCID: PMC3698576.
      11. Easley CA, Miki T, Castro CA, Ozolek JA, Minervini CF, Ben-Yehudah A, Schatten GP. Human amniotic epithelial cells are reprogrammed more efficiently by induced pluripotency than adult fibroblasts. Cell Reprogram. 2012 Jun; 14(3):193-203. PMID: 22686477; PMCID: PMC4361010.
      12. Gridelli B, Vizzini G, Pietrosi G, Luca A, Spada M, Gruttadauria S, Cintorino D, Amico G, Chinnici C, Miki T, Schmelzer E, Conaldi PG, Triolo F, Gerlach JC. Efficient human fetal liver cell isolation protocol based on vascular perfusion for liver cell-based therapy and case report on cell transplantation. Liver Transpl. 2012 Feb; 18(2):226-37. PMID: 22034152.
        View in: PubMed
      13. Housler GJ, Miki T, Schmelzer E, Pekor C, Zhang X, Kang L, Voskinarian-Berse V, Abbot S, Zeilinger K, Gerlach JC. Compartmental hollow fiber capillary membrane-based bioreactor technology for in vitro studies on red blood cell lineage direction of hematopoietic stem cells. Tissue Eng Part C Methods. 2012 Feb; 18(2):133-42. PMID: 21933020; PMCID: PMC3262978.
      14. Miki T, Yasuda SY, Kahn M. Wnt/ß-catenin signaling in embryonic stem cell self-renewal and somatic cell reprogramming. Stem Cell Rev. 2011 Nov; 7(4):836-46. PMID: 21603945.
        View in: PubMed
      15. Miki T. Amnion-derived stem cells: in quest of clinical applications. Stem Cell Res Ther. 2011 May 19; 2(3):25. PMID: 21596003; PMCID: PMC3152995.
      16. Marongiu F, Gramignoli R, Dorko K, Miki T, Ranade AR, Paola Serra M, Doratiotto S, Sini M, Sharma S, Mitamura K, Sellaro TL, Tahan V, Skvorak KJ, Ellis EC, Badylak SF, Davila JC, Hines R, Laconi E, Strom SC. Hepatic differentiation of amniotic epithelial cells. Hepatology. 2011 May; 53(5):1719-29. PMID: 21374689; PMCID: PMC3103747.
      17. Miki T, Ring A, Gerlach J. Hepatic differentiation of human embryonic stem cells is promoted by three-dimensional dynamic perfusion culture conditions. Tissue Eng Part C Methods. 2011 May; 17(5):557-68. PMID: 21210720.
        View in: PubMed
      18. Ring A, Gerlach J, Peters G, Pazin BJ, Minervini CF, Turner ME, Thompson RL, Triolo F, Gridelli B, Miki T. Hepatic maturation of human fetal hepatocytes in four-compartment three-dimensional perfusion culture. Tissue Eng Part C Methods. 2010 Oct; 16(5):835-45. PMID: 19883207.
        View in: PubMed
      19. Marongiu F, Gramignoli R, Sun Q, Tahan V, Miki T, Dorko K, Ellis E, Strom SC. Isolation of amniotic mesenchymal stem cells. Curr Protoc Stem Cell Biol. 2010 Mar; Chapter 1:Unit 1E.5. PMID: 20200854.
        View in: PubMed
      20. Gerlach JC, Lübberstedt M, Edsbagge J, Ring A, Hout M, Baun M, Rossberg I, Knöspel F, Peters G, Eckert K, Wulf-Goldenberg A, Björquist P, Stachelscheid H, Urbaniak T, Schatten G, Miki T, Schmelzer E, Zeilinger K. Interwoven four-compartment capillary membrane technology for three-dimensional perfusion with decentralized mass exchange to scale up embryonic stem cell culture. Cells Tissues Organs. 2010; 192(1):39-49. PMID: 20197653; PMCID: PMC2895759.
      21. Hashizume R, Fujimoto KL, Hong Y, Amoroso NJ, Tobita K, Miki T, Keller BB, Sacks MS, Wagner WR. Morphological and mechanical characteristics of the reconstructed rat abdominal wall following use of a wet electrospun biodegradable polyurethane elastomer scaffold. Biomaterials. 2010 Apr; 31(12):3253-65. PMID: 20138661; PMCID: PMC3182828.
      22. Gerlach JC, Hout M, Edsbagge J, Björquist P, Lübberstedt M, Miki T, Stachelscheid H, Schmelzer E, Schatten G, Zeilinger K. Dynamic 3D culture promotes spontaneous embryonic stem cell differentiation in vitro. Tissue Eng Part C Methods. 2010 Feb; 16(1):115-21. PMID: 19382830; PMCID: PMC2819805.
      23. Miki T, Marongiu F, Dorko K, Ellis EC, Strom SC. Isolation of amniotic epithelial stem cells. Curr Protoc Stem Cell Biol. 2010 Jan; Chapter 1:Unit 1E.3. PMID: 20049689.
        View in: PubMed
      24. Izumi M, Pazin BJ, Minervini CF, Gerlach J, Ross MA, Stolz DB, Turner ME, Thompson RL, Miki T. Quantitative comparison of stem cell marker-positive cells in fetal and term human amnion. J Reprod Immunol. 2009 Jul; 81(1):39-43. PMID: 19501410.
        View in: PubMed
      25. Minervini CF, Izumi M, Miki T. Effect of Culture Conditions on Reference Genes Expression in Placenta-derived Stem Cells. Int J Stem Cells. 2009 May; 2(1):69-75. PMID: 24855522; PMCID: PMC4021796.
      26. Fujimoto KL, Miki T, Liu LJ, Hashizume R, Strom SC, Wagner WR, Keller BB, Tobita K. Naive rat amnion-derived cell transplantation improved left ventricular function and reduced myocardial scar of postinfarcted heart. Cell Transplant. 2009; 18(4):477-86. PMID: 19622235.
        View in: PubMed
      27. Miki T, Marongiu F, Ellis EC, Dorko K, Mitamura K, Ranade A, Gramignoli R, Davila J, Strom SC. Production of hepatocyte-like cells from human amnion. Methods Mol Biol. 2009; 481:155-68. PMID: 19096803.
        View in: PubMed
      28. Parolini O, Alviano F, Bagnara GP, Bilic G, Bühring HJ, Evangelista M, Hennerbichler S, Liu B, Magatti M, Mao N, Miki T, Marongiu F, Nakajima H, Nikaido T, Portmann-Lanz CB, Sankar V, Soncini M, Stadler G, Surbek D, Takahashi TA, Redl H, Sakuragawa N, Wolbank S, Zeisberger S, Zisch A, Strom SC. Concise review: isolation and characterization of cells from human term placenta: outcome of the first international Workshop on Placenta Derived Stem Cells. Stem Cells. 2008 Feb; 26(2):300-11. PMID: 17975221.
        View in: PubMed
      29. Miki T, Marongiu F, Ellis E, C Strom S. Isolation of amniotic epithelial stem cells. Curr Protoc Stem Cell Biol. 2007 Nov; Chapter 1:Unit 1E.3. PMID: 18785168.
        View in: PubMed
      30. Miki T, Mitamura K, Ross MA, Stolz DB, Strom SC. Identification of stem cell marker-positive cells by immunofluorescence in term human amnion. J Reprod Immunol. 2007 Oct; 75(2):91-6. PMID: 17493686.
        View in: PubMed
      31. Strom SC, Bruzzone P, Cai H, Ellis E, Lehmann T, Mitamura K, Miki T. Hepatocyte transplantation: clinical experience and potential for future use. Cell Transplant. 2006; 15 Suppl 1:S105-10. PMID: 16826802.
        View in: PubMed
      32. Miki T, Strom SC. Amnion-derived pluripotent/multipotent stem cells. Stem Cell Rev. 2006; 2(2):133-42. PMID: 17237552.
        View in: PubMed
      33. Strom SC, Cai H, Ellis E, Mitamura K, Miki T. Bigger may not be better when it comes to hepatocytes. Liver Transpl. 2006 Jan; 12(1):16-8. PMID: 16382453.
        View in: PubMed
      34. Miki T, Lehmann T, Cai H, Stolz DB, Strom SC. Stem cell characteristics of amniotic epithelial cells. Stem Cells. 2005 Nov-Dec; 23(10):1549-59. PMID: 16081662.
        View in: PubMed
      35. Davila JC, Cezar GG, Thiede M, Strom S, Miki T, Trosko J. Use and application of stem cells in toxicology. Toxicol Sci. 2004 Jun; 79(2):214-23. PMID: 15014205.
        View in: PubMed
      36. Wakizaka Y, Miki T, Rao AS, Wang X, Goller AL, Demetris AJ, Fung JJ, Starzl TE, Valdivia LA. Correction of congenital hyperbilirubinemia in homozygous Gunn rats by xenotransplantation of hamster livers. Xenotransplantation. 1997 Nov 01; 4(4):262-266. PMID: 21318077.
        View in: PubMed