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Todd E. Morgan, PhD

Title(s)Research Professor Of Gerontology
Phone+1 213 740 4083
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    Todd Morgan, Ph.D. is a Research Associate Professor of Gerontology at the University of Southern California. In 1984, he received his B.S. in Chemistry at Dana College in Blair, Nebraska. He then studied at Colorado State University for his Ph.D. in Biochemistry and at USC for his Post-Doctorate in Neurobiology.

    Professor Morgan has been awarded the “Glial Aging & Inflammatory Mechanisms in AD” Pilot Award at USC’s Alzheimer’s Disease Research Center and the “CR & Inflammatory Mechanisms in AD” Temple Award, the “Regulation of Complement Expression” Turken Award, and the “Clusterin Regulation & Activity During Neurodegeneration” Faculty Scholar Award at the Alzheimer’s Association.

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    Dietary Restriction, GH/IGF-1 & Mechanisms of Cellular Protection and Regeneration
    NIH/NIA P01AG055369Feb 15, 2018 - Jan 31, 2023
    Role: Co-Principal Investigator
    TGF-B1 AND THE HIPPOCAMPAL RESPONSE TO LESIONS
    NIH/NIA F32AG005589Sep 25, 1992
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Zhang H, Haghani A, Mousavi AH, Cacciottolo M, D'Agostino C, Safi N, Sowlat MH, Sioutas C, Morgan TE, Finch CE, Forman HJ. Cell-based assays that predict in vivo neurotoxicity of urban ambient nano-sized particulate matter. Free Radic Biol Med. 2019 Sep 19; 145:33-41. PMID: 31542466.
      View in: PubMed
    2. Breton CV, Song AY, Xiao J, Kim SJ, Mehta HH, Wan J, Yen K, Sioutas C, Lurmann F, Xue S, Morgan TE, Zhang J, Cohen P. Effects of air pollution on mitochondrial function, mitochondrial DNA methylation, and mitochondrial peptide expression. Mitochondrion. 2019 05; 46:22-29. PMID: 30980914.
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    3. Haghani A, Dalton HM, Safi N, Shirmohammadi F, Sioutas C, Morgan TE, Finch CE, Curran SP. Air pollution alters Caenorhabditis elegans development and lifespan: responses to traffic-related nanoparticulate matter (nPM). J Gerontol A Biol Sci Med Sci. 2019 Mar 04. PMID: 30828708.
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    4. Woodward NC, Crow AL, Zhang Y, Epstein S, Hartiala J, Johnson R, Kocalis H, Saffari A, Sankaranarayanan I, Akbari O, Ramanathan G, Araujo JA, Finch CE, Bouret SG, Sioutas C, Morgan TE, Allayee H. Exposure to Nanoscale Particulate Matter from Gestation to Adulthood Impairs Metabolic Homeostasis in Mice. Sci Rep. 2019 Feb 12; 9(1):1816. PMID: 30755631.
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    5. Babadjouni R, Patel A, Liu Q, Shkirkova K, Lamorie-Foote K, Connor M, Hodis DM, Cheng H, Sioutas C, Morgan TE, Finch CE, Mack WJ. Nanoparticulate matter exposure results in neuroinflammatory changes in the corpus callosum. PLoS One. 2018; 13(11):e0206934. PMID: 30395590.
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    6. Lovett C, Cacciottolo M, Shirmohammadi F, Haghani A, Morgan TE, Sioutas C, Finch CE. Diurnal variation in the proinflammatory activity of urban fine particulate matter (PM 2.5) by in vitro assays. F1000Res. 2018; 7:596. PMID: 30345019.
      View in: PubMed
    7. Pomatto LCD, Cline M, Woodward N, Pakbin P, Sioutas C, Morgan TE, Finch CE, Forman HJ, Davies KJA. Aging attenuates redox adaptive homeostasis and proteostasis in female mice exposed to traffic-derived nanoparticles ('vehicular smog'). Free Radic Biol Med. 2018 06; 121:86-97. PMID: 29709705.
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    8. Giri VN, Knudsen KE, Kelly WK, Abida W, Andriole GL, Bangma CH, Bekelman JE, Benson MC, Blanco A, Burnett A, Catalona WJ, Cooney KA, Cooperberg M, Crawford DE, Den RB, Dicker AP, Eggener S, Fleshner N, Freedman ML, Hamdy FC, Hoffman-Censits J, Hurwitz MD, Hyatt C, Isaacs WB, Kane CJ, Kantoff P, Karnes RJ, Karsh LI, Klein EA, Lin DW, Loughlin KR, Lu-Yao G, Malkowicz SB, Mann MJ, Mark JR, McCue PA, Miner MM, Morgan T, Moul JW, Myers RE, Nielsen SM, Obeid E, Pavlovich CP, Peiper SC, Penson DF, Petrylak D, Pettaway CA, Pilarski R, Pinto PA, Poage W, Raj GV, Rebbeck TR, Robson ME, Rosenberg MT, Sandler H, Sartor O, Schaeffer E, Schwartz GF, Shahin MS, Shore ND, Shuch B, Soule HR, Tomlins SA, Trabulsi EJ, Uzzo R, Vander Griend DJ, Walsh PC, Weil CJ, Wender R, Gomella LG. Role of Genetic Testing for Inherited Prostate Cancer Risk: Philadelphia Prostate Cancer Consensus Conference 2017. J Clin Oncol. 2018 02 01; 36(4):414-424. PMID: 29236593.
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    9. Woodward NC, Levine MC, Haghani A, Shirmohammadi F, Saffari A, Sioutas C, Morgan TE, Finch CE. Toll-like receptor 4 in glial inflammatory responses to air pollution in vitro and in vivo. J Neuroinflammation. 2017 04 14; 14(1):84. PMID: 28410596.
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    10. Wei M, Brandhorst S, Shelehchi M, Mirzaei H, Cheng CW, Budniak J, Groshen S, Mack WJ, Guen E, Di Biase S, Cohen P, Morgan TE, Dorff T, Hong K, Michalsen A, Laviano A, Longo VD. Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease. Sci Transl Med. 2017 02 15; 9(377). PMID: 28202779.
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    11. Lee AS, Brandhorst S, Rangel DF, Navarrete G, Cohen P, Longo VD, Chen J, Groshen S, Morgan TE, Dubeau L. Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice. Sci Rep. 2017 02 01; 7:40919. PMID: 28145503.
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    12. Woodward NC, Pakbin P, Saffari A, Shirmohammadi F, Haghani A, Sioutas C, Cacciottolo M, Morgan TE, Finch CE. Traffic-related air pollution impact on mouse brain accelerates myelin and neuritic aging changes with specificity for CA1 neurons. Neurobiol Aging. 2017 05; 53:48-58. PMID: 28212893.
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    13. Di Biase S, Lee C, Brandhorst S, Manes B, Buono R, Cheng CW, Cacciottolo M, Martin-Montalvo A, de Cabo R, Wei M, Morgan TE, Longo VD. Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity. Cancer Cell. 2016 07 11; 30(1):136-146. PMID: 27411588.
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    14. Choi IY, Piccio L, Childress P, Bollman B, Ghosh A, Brandhorst S, Suarez J, Michalsen A, Cross AH, Morgan TE, Wei M, Paul F, Bock M, Longo VD. A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms. Cell Rep. 2016 06 07; 15(10):2136-2146. PMID: 27239035.
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    15. Cheng H, Saffari A, Sioutas C, Forman HJ, Morgan TE, Finch CE. Nanoscale Particulate Matter from Urban Traffic Rapidly Induces Oxidative Stress and Inflammation in Olfactory Epithelium with Concomitant Effects on Brain. Environ Health Perspect. 2016 Oct; 124(10):1537-1546. PMID: 27187980.
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    16. Liu Q, Babadjouni R, Radwanski R, Cheng H, Patel A, Hodis DM, He S, Baumbacher P, Russin JJ, Morgan TE, Sioutas C, Finch CE, Mack WJ. Stroke Damage Is Exacerbated by Nano-Size Particulate Matter in a Mouse Model. PLoS One. 2016; 11(4):e0153376. PMID: 27071057.
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    17. Cheng H, Davis DA, Hasheminassab S, Sioutas C, Morgan TE, Finch CE. Urban traffic-derived nanoparticulate matter reduces neurite outgrowth via TNFa in vitro. J Neuroinflammation. 2016 Jan 26; 13:19. PMID: 26810976.
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    18. Cacciottolo M, Christensen A, Moser A, Liu J, Pike CJ, Smith C, LaDu MJ, Sullivan PM, Morgan TE, Dolzhenko E, Charidimou A, Wahlund LO, Wiberg MK, Shams S, Chiang GC, Finch CE. The APOE4 allele shows opposite sex bias in microbleeds and Alzheimer's disease of humans and mice. Neurobiol Aging. 2016 Jan; 37:47-57. PMID: 26686669.
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    19. Morgan TE, Finch CE. Astrocytic estrogen receptors and impaired neurotrophic responses in a rat model of perimenopause. Front Aging Neurosci. 2015; 7:179. PMID: 26483679.
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    20. Wright TT, Jimenez RV, Morgan TE, Bali N, Hou X, McCrory MA, Finch CE, Szalai AJ. Hepatic but Not CNS-Expressed Human C-Reactive Protein Inhibits Experimental Autoimmune Encephalomyelitis in Transgenic Mice. Autoimmune Dis. 2015; 2015:640171. PMID: 26421184.
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    21. Brandhorst S, Choi IY, Wei M, Cheng CW, Sedrakyan S, Navarrete G, Dubeau L, Yap LP, Park R, Vinciguerra M, Di Biase S, Mirzaei H, Mirisola MG, Childress P, Ji L, Groshen S, Penna F, Odetti P, Perin L, Conti PS, Ikeno Y, Kennedy BK, Cohen P, Morgan TE, Dorff TB, Longo VD. A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. Cell Metab. 2015 Jul 07; 22(1):86-99. PMID: 26094889.
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    22. Woodward N, Finch CE, Morgan TE. Traffic-related air pollution and brain development. AIMS Environ Sci. 2015; 2(2):353-373. PMID: 27099868.
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    23. Yin F, Yao J, Sancheti H, Feng T, Melcangi RC, Morgan TE, Finch CE, Pike CJ, Mack WJ, Cadenas E, Brinton RD. The perimenopausal aging transition in the female rat brain: decline in bioenergetic systems and synaptic plasticity. Neurobiol Aging. 2015 Jul; 36(7):2282-2295. PMID: 25921624.
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    24. Barron AM, Brown MA, Morgan TE, Pike CJ. Impact of continuous versus discontinuous progesterone on estradiol regulation of neuron viability and sprouting after entorhinal cortex lesion in female rats. Endocrinology. 2015 Mar; 156(3):1091-9. PMID: 25514084.
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    25. Davis DA, Akopian G, Walsh JP, Sioutas C, Morgan TE, Finch CE. Urban air pollutants reduce synaptic function of CA1 neurons via an NMDA/N? pathway in vitro. J Neurochem. 2013 Nov; 127(4):509-19. PMID: 23927064.
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    26. Davis DA, Bortolato M, Godar SC, Sander TK, Iwata N, Pakbin P, Shih JC, Berhane K, McConnell R, Sioutas C, Finch CE, Morgan TE. Prenatal exposure to urban air nanoparticles in mice causes altered neuronal differentiation and depression-like responses. PLoS One. 2013; 8(5):e64128. PMID: 23734187.
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    27. Li R, Navab M, Pakbin P, Ning Z, Navab K, Hough G, Morgan TE, Finch CE, Araujo JA, Fogelman AM, Sioutas C, Hsiai T. Ambient ultrafine particles alter lipid metabolism and HDL anti-oxidant capacity in LDLR-null mice. J Lipid Res. 2013 Jun; 54(6):1608-15. PMID: 23564731.
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    28. Arimoto JM, Wong A, Rozovsky I, Lin SW, Morgan TE, Finch CE. Age increase of estrogen receptor-a (ERa) in cortical astrocytes impairs neurotrophic support in male and female rats. Endocrinology. 2013 Jun; 154(6):2101-13. PMID: 23515288.
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    29. Brandhorst S, Wei M, Hwang S, Morgan TE, Longo VD. Short-term calorie and protein restriction provide partial protection from chemotoxicity but do not delay glioma progression. Exp Gerontol. 2013 Oct; 48(10):1120-8. PMID: 23454633.
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    30. Chepelev NL, Zhang H, Liu H, McBride S, Seal AJ, Morgan TE, Finch CE, Willmore WG, Davies KJ, Forman HJ. Competition of nuclear factor-erythroid 2 factors related transcription factor isoforms, Nrf1 and Nrf2, in antioxidant enzyme induction. Redox Biol. 2013; 1:183-9. PMID: 24024152.
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    31. Pfaffenbach KT, Pong M, Morgan TE, Wang H, Ott K, Zhou B, Longo VD, Lee AS. GRP78/BiP is a novel downstream target of IGF-1 receptor mediated signaling. J Cell Physiol. 2012 Dec; 227(12):3803-11. PMID: 22422508.
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    32. Jayaraman A, Carroll JC, Morgan TE, Lin S, Zhao L, Arimoto JM, Murphy MP, Beckett TL, Finch CE, Brinton RD, Pike CJ. 17ß-estradiol and progesterone regulate expression of ß-amyloid clearance factors in primary neuron cultures and female rat brain. Endocrinology. 2012 Nov; 153(11):5467-79. PMID: 22962256.
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    33. Zhang H, Liu H, Davies KJ, Sioutas C, Finch CE, Morgan TE, Forman HJ. Nrf2-regulated phase II enzymes are induced by chronic ambient nanoparticle exposure in young mice with age-related impairments. Free Radic Biol Med. 2012 May 01; 52(9):2038-46. PMID: 22401859.
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    34. Zhao L, Morgan TE, Mao Z, Lin S, Cadenas E, Finch CE, Pike CJ, Mack WJ, Brinton RD. Continuous versus cyclic progesterone exposure differentially regulates hippocampal gene expression and functional profiles. PLoS One. 2012; 7(2):e31267. PMID: 22393359.
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    35. Simmons MS, Artal R, Burch MA, Cain RP, Campano R, Cohen HG, Mann CA, Morgan T, Owens JA, Pullinger A, Relle R, Roesler JM, Sotos J, Yagiela JA, Ziman RB, Simmons JH. Dentistry-based approaches to sleep-disordered breathing, algorithms, and multidisciplinary perspectives. J Calif Dent Assoc. 2012 Feb; 40(2):168-81. PMID: 22416636.
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    36. Kremsky I, Morgan TE, Hou X, Li L, Finch CE. Age-changes in gene expression in primary mixed glia cultures from young vs. old rat cerebral cortex are modified by interactions with neurons. Brain Behav Immun. 2012 Jul; 26(5):797-802. PMID: 22226781.
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    37. Bali N, Arimoto JM, Iwata N, Lin SW, Zhao L, Brinton RD, Morgan TE, Finch CE. Differential responses of progesterone receptor membrane component-1 (Pgrmc1) and the classical progesterone receptor (Pgr) to 17ß-estradiol and progesterone in hippocampal subregions that support synaptic remodeling and neurogenesis. Endocrinology. 2012 Feb; 153(2):759-69. PMID: 22147012.
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    38. Morgan TE, Davis DA, Iwata N, Tanner JA, Snyder D, Ning Z, Kam W, Hsu YT, Winkler JW, Chen JC, Petasis NA, Baudry M, Sioutas C, Finch CE. Glutamatergic neurons in rodent models respond to nanoscale particulate urban air pollutants in vivo and in vitro. Environ Health Perspect. 2011 Jul; 119(7):1003-9. PMID: 21724521.
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    39. Finch CE, Morgan TE, Longo VD, de Magalhaes JP. Cell resilience in species life spans: a link to inflammation? Aging Cell. 2010 Aug; 9(4):519-26. PMID: 20415721.
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    40. Nunez-Iglesias J, Liu CC, Morgan TE, Finch CE, Zhou XJ. Joint genome-wide profiling of miRNA and mRNA expression in Alzheimer's disease cortex reveals altered miRNA regulation. PLoS One. 2010 Feb 01; 5(2):e8898. PMID: 20126538.
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    41. Wong AM, Rozovsky I, Arimoto JM, Du Y, Wei M, Morgan TE, Finch CE. Progesterone influence on neurite outgrowth involves microglia. Endocrinology. 2009 Jan; 150(1):324-32. PMID: 18772232.
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    42. Faghihi MA, Modarresi F, Khalil AM, Wood DE, Sahagan BG, Morgan TE, Finch CE, St Laurent G, Kenny PJ, Wahlestedt C. Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase. Nat Med. 2008 Jul; 14(7):723-30. PMID: 18587408.
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    43. Brinton RD, Thompson RF, Foy MR, Baudry M, Wang J, Finch CE, Morgan TE, Pike CJ, Mack WJ, Stanczyk FZ, Nilsen J. Progesterone receptors: form and function in brain. Front Neuroendocrinol. 2008 May; 29(2):313-39. PMID: 18374402.
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    44. Finch CE, Morgan TE. Systemic inflammation, infection, ApoE alleles, and Alzheimer disease: a position paper. Curr Alzheimer Res. 2007 Apr; 4(2):185-9. PMID: 17430245.
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    45. Morgan TE, Wong AM, Finch CE. Anti-inflammatory mechanisms of dietary restriction in slowing aging processes. Interdiscip Top Gerontol. 2007; 35:83-97. PMID: 17063034.
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    46. Wong AM, Patel NV, Patel NK, Wei M, Morgan TE, de Beer MC, de Villiers WJ, Finch CE. Macrosialin increases during normal brain aging are attenuated by caloric restriction. Neurosci Lett. 2005 Dec 23; 390(2):76-80. PMID: 16157452.
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    47. Rozovsky I, Wei M, Morgan TE, Finch CE. Reversible age impairments in neurite outgrowth by manipulations of astrocytic GFAP. Neurobiol Aging. 2005 May; 26(5):705-15. PMID: 15708446.
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    48. Zhou XJ, Kao MC, Huang H, Wong A, Nunez-Iglesias J, Primig M, Aparicio OM, Finch CE, Morgan TE, Wong WH. Functional annotation and network reconstruction through cross-platform integration of microarray data. Nat Biotechnol. 2005 Feb; 23(2):238-43. PMID: 15654329.
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    49. Patel NV, Gordon MN, Connor KE, Good RA, Engelman RW, Mason J, Morgan DG, Morgan TE, Finch CE. Caloric restriction attenuates Abeta-deposition in Alzheimer transgenic models. Neurobiol Aging. 2005 Jul; 26(7):995-1000. PMID: 15748777.
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    50. Patel NV, Wei M, Wong A, Finch CE, Morgan TE. Progressive changes in regulation of apolipoproteins E and J in glial cultures during postnatal development and aging. Neurosci Lett. 2004 Nov 23; 371(2-3):199-204. PMID: 15519757.
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    51. Wilhelmsson U, Li L, Pekna M, Berthold CH, Blom S, Eliasson C, Renner O, Bushong E, Ellisman M, Morgan TE, Pekny M. Absence of glial fibrillary acidic protein and vimentin prevents hypertrophy of astrocytic processes and improves post-traumatic regeneration. J Neurosci. 2004 May 26; 24(21):5016-21. PMID: 15163694.
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    52. Xie Z, Morgan TE, Rozovsky I, Finch CE. Aging and glial responses to lipopolysaccharide in vitro: greater induction of IL-1 and IL-6, but smaller induction of neurotoxicity. Exp Neurol. 2003 Jul; 182(1):135-41. PMID: 12821383.
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    53. Xie Z, Wei M, Morgan TE, Fabrizio P, Han D, Finch CE, Longo VD. Peroxynitrite mediates neurotoxicity of amyloid beta-peptide1-42- and lipopolysaccharide-activated microglia. J Neurosci. 2002 May 01; 22(9):3484-92. PMID: 11978825.
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    54. Rozovsky I, Wei M, Stone DJ, Zanjani H, Anderson CP, Morgan TE, Finch CE. Estradiol (E2) enhances neurite outgrowth by repressing glial fibrillary acidic protein expression and reorganizing laminin. Endocrinology. 2002 Feb; 143(2):636-46. PMID: 11796520.
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    55. Morgan TE, Rozovsky I, Sarkar DK, Young-Chan CS, Nichols NR, Laping NJ, Finch CE. Transforming growth factor-beta1 induces transforming growth factor-beta1 and transforming growth factor-beta receptor messenger RNAs and reduces complement C1qB messenger RNA in rat brain microglia. Neuroscience. 2000; 101(2):313-21. PMID: 11074155.
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