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Thomas H. Mc Neill, PhD

Title(s)Professor of Cell & Neurobiology
Phone+1 323 442 1625
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    Research Overview
    The overall goal of Dr. McNeill's research program is to define the cellular mechanisms that regulate the ability of the brain to repair itself in response to injury (i.e. neuroplasticity) and the effect of aging on these processes. In particular, we wish to further our understanding of the cellular events underlying the synergism between neural plasticity and treatment strategies that promote the recovery of function after brain damage. Understanding the cellular mechanisms that promote neuroplasticity after brain injury is critical for determining the limits of functional recovery that can be expected in brain injured patients, and the first step in developing novel treatment strategies to facilitate the recovery of function after brain injury. Likewise, the ability to manipulate neurotrophrin and neurotransmitters pathways that are activated in response to injury offers a unique opportunity for the development of novel therapies that target a specific cellular mechanisms by translating the fundemental principles of neuroplasticty into effective clinical interventions. The knowledge gained from our studies has relevance for the treatment of neuropsychiatric disorders commonly associated with brain injury as well as in the treatment of neurological deficits associated with Parkinson's disease, Alzheimer's disease, schizophrenia and stroke

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Gopalakrishna R, Gundimeda U, Zhou S, Bui H, Davis A, McNeill T, Mack W. Laminin-1 induces endocytosis of 67KDa laminin receptor and protects Neuroscreen-1 cells against death induced by serum withdrawal. Biochem Biophys Res Commun. 2018 01 01; 495(1):230-237. PMID: 29108990.
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    2. Gundimeda U, McNeill TH, Barseghian BA, Tzeng WS, Rayudu DV, Cadenas E, Gopalakrishna R. Polyphenols from green tea prevent antineuritogenic action of Nogo-A via 67-kDa laminin receptor and hydrogen peroxide. J Neurochem. 2015 Jan; 132(1):70-84. PMID: 25314656.
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    3. Gundimeda U, McNeill TH, Fan TK, Deng R, Rayudu D, Chen Z, Cadenas E, Gopalakrishna R. Green tea catechins potentiate the neuritogenic action of brain-derived neurotrophic factor: role of 67-kDa laminin receptor and hydrogen peroxide. Biochem Biophys Res Commun. 2014 Feb 28; 445(1):218-24. PMID: 24508265.
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    4. Kent K, Deng Q, McNeill TH. Unilateral skill acquisition induces bilateral NMDA receptor subunit composition shifts in the rat sensorimotor striatum. Brain Res. 2013 Jun 23; 1517:77-86. PMID: 23603403.
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    5. Gopalakrishna R, McNeill TH, Elhiani AA, Gundimeda U. Methods for studying oxidative regulation of protein kinase C. Methods Enzymol. 2013; 528:79-98. PMID: 23849860.
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    6. Gundimeda U, McNeill TH, Elhiani AA, Schiffman JE, Hinton DR, Gopalakrishna R. Green tea polyphenols precondition against cell death induced by oxygen-glucose deprivation via stimulation of laminin receptor, generation of reactive oxygen species, and activation of protein kinase Ce. J Biol Chem. 2012 Oct 05; 287(41):34694-708. PMID: 22879598.
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    7. Gundimeda U, McNeill TH, Schiffman JE, Hinton DR, Gopalakrishna R. Green tea polyphenols potentiate the action of nerve growth factor to induce neuritogenesis: possible role of reactive oxygen species. J Neurosci Res. 2010 Dec; 88(16):3644-55. PMID: 20936703.
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    8. Kong S, Lorenzana A, Deng Q, McNeill TH, Schauwecker PE. Variation in Galr1 expression determines susceptibility to exocitotoxin-induced cell death in mice. Genes Brain Behav. 2008 Jul; 7(5):587-98. PMID: 18363852.
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    9. Gopalakrishna R, Gundimeda U, Schiffman JE, McNeill TH. A direct redox regulation of protein kinase C isoenzymes mediates oxidant-induced neuritogenesis in PC12 cells. J Biol Chem. 2008 May 23; 283(21):14430-44. PMID: 18375950.
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    10. Davis EJ, Coyne C, McNeill TH. Intrastriatal dopamine D1 antagonism dampens neural plasticity in response to motor cortex lesion. Neuroscience. 2007 May 11; 146(2):784-91. PMID: 17331653.
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    11. Hughes-Davis EJ, Cogen JP, Jakowec MW, Cheng HW, Grenningloh G, Meshul CK, McNeill TH. Differential regulation of the growth-associated proteins GAP-43 and superior cervical ganglion 10 in response to lesions of the cortex and substantia nigra in the adult rat. Neuroscience. 2005; 135(4):1231-9. PMID: 16165289.
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    12. McNeill TH, Brown SA, Hogg E, Cheng HW, Meshul CK. Synapse replacement in the striatum of the adult rat following unilateral cortex ablation. J Comp Neurol. 2003 Dec 01; 467(1):32-43. PMID: 14574678.
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    13. Meshul CK, Cogen JP, Cheng HW, Moore C, Krentz L, McNeill TH. Alterations in rat striatal glutamate synapses following a lesion of the cortico- and/or nigrostriatal pathway. Exp Neurol. 2000 Sep; 165(1):191-206. PMID: 10964498.
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    14. McNeill TH, Mori N, Cheng HW. Differential regulation of the growth-associated proteins, GAP-43 and SCG-10, in response to unilateral cortical ablation in adult rats. Neuroscience. 1999; 90(4):1349-60. PMID: 10338302.
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    15. Cheng HW, Tong J, McNeill TH. Lesion-induced axon sprouting in the deafferented striatum of adult rat. Neurosci Lett. 1998 Feb 13; 242(2):69-72. PMID: 9533396.
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    16. Snyder SE, Cheng HW, Murray KD, Isackson PJ, McNeill TH, Salton SR. The messenger RNA encoding VGF, a neuronal peptide precursor, is rapidly regulated in the rat central nervous system by neuronal activity, seizure and lesion. Neuroscience. 1998 Jan; 82(1):7-19. PMID: 9483499.
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    17. Schauwecker PE, Cogen JP, Jiang T, Cheng HW, Collier TJ, McNeill TH. Differential regulation of astrocytic mRNAs in the rat striatum after lesions of the cortex or substantia nigra. Exp Neurol. 1998 Jan; 149(1):87-96. PMID: 9454618.
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    18. Cheng HW, Jiang T, Mori N, McNeill TH. Upregulation of stathmin (p19) gene expression in adult rat brain during injury-induced synapse formation. Neuroreport. 1997 Dec 01; 8(17):3691-5. PMID: 9427352.
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    19. Cheng HW, Rafols JA, Goshgarian HG, Anavi Y, Tong J, McNeill TH. Differential spine loss and regrowth of striatal neurons following multiple forms of deafferentation: a Golgi study. Exp Neurol. 1997 Oct; 147(2):287-98. PMID: 9344554.
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    20. Ou X, Buckwalter G, McNeill TH, Walsh JP. Age-related change in short-term synaptic plasticity intrinsic to excitatory striatal synapses. Synapse. 1997 Sep; 27(1):57-68. PMID: 9268065.
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    21. Andersen JK, Mo JQ, Hom DG, Lee FY, Harnish P, Hamill RW, McNeill TH. Effect of buthionine sulfoximine, a synthesis inhibitor of the antioxidant glutathione, on the murine nigrostriatal neurons. J Neurochem. 1996 Nov; 67(5):2164-71. PMID: 8863527.
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    22. Dunia R, Buckwalter G, Defazio T, Villar FD, McNeill TH, Walsh JP. Decreased duration of Ca(2+)-mediated plateau potentials in striatal neurons from aged rats. J Neurophysiol. 1996 Oct; 76(4):2353-63. PMID: 8899609.
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    23. Schauwecker PE, McNeill TH. Dendritic remodeling of dentate granule cells following a combined entorhinal cortex/fimbria fornix lesion. Exp Neurol. 1996 Sep; 141(1):145-53. PMID: 8797677.
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    24. Schauwecker PE, Cheng HW, Serquinia RM, Mori N, McNeill TH. Lesion-induced sprouting of commissural/associational axons and induction of GAP-43 mRNA in hilar and CA3 pyramidal neurons in the hippocampus are diminished in aged rats. J Neurosci. 1995 Mar; 15(3 Pt 2):2462-70. PMID: 7891181.
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    25. Schauwecker PE, McNeill TH. Enhanced but delayed axonal sprouting of the commissural/associational pathway following a combined entorhinal cortex/fimbria fornix lesion. J Comp Neurol. 1995 Jan 16; 351(3):453-64. PMID: 7535807.
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    26. Kohama SG, Goss JR, Finch CE, McNeill TH. Increases of glial fibrillary acidic protein in the aging female mouse brain. Neurobiol Aging. 1995 Jan-Feb; 16(1):59-67. PMID: 7723937.
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    27. Cheng HW, Jiang T, Brown SA, Pasinetti GM, Finch CE, McNeill TH. Response of striatal astrocytes to neuronal deafferentation: an immunocytochemical and ultrastructural study. Neuroscience. 1994 Sep; 62(2):425-39. PMID: 7830889.
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    28. Himi T, Okazaki T, Wang H, McNeill TH, Mori N. Differential localization of SCG10 and p19/stathmin messenger RNAs in adult rat brain indicates distinct roles for these growth-associated proteins. Neuroscience. 1994 Jun; 60(4):907-26. PMID: 7936211.
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    29. Beck KD, Lamballe F, Klein R, Barbacid M, Schauwecker PE, McNeill TH, Finch CE, Hefti F, Day JR. Induction of noncatalytic TrkB neurotrophin receptors during axonal sprouting in the adult hippocampus. J Neurosci. 1993 Sep; 13(9):4001-14. PMID: 8396171.
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    30. Day JR, Laping NJ, Lampert-Etchells M, Brown SA, O'Callaghan JP, McNeill TH, Finch CE. Gonadal steroids regulate the expression of glial fibrillary acidic protein in the adult male rat hippocampus. Neuroscience. 1993 Jul; 55(2):435-43. PMID: 8377935.
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    31. Pasinetti GM, Cheng HW, Morgan DG, Lampert-Etchells M, McNeill TH, Finch CE. Astrocytic messenger RNA responses to striatal deafferentation in male rat. Neuroscience. 1993 Mar; 53(1):199-211. PMID: 8469307.
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    32. Kohama SG, Brown SA, Finch CE, McNeill TH. Chronic estradiol administration did not cause loss of hypothalamic LHRH or TIDA neurons in young or middle-aged C57BL/6J mice. Brain Res. 1992 Mar 06; 574(1-2):341-4. PMID: 1638407.
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    33. Pasinetti GM, Kohama S, Reinhard JF, Cheng HW, McNeill TH, Finch CE. Striatal responses to decortication. I. Dopaminergic and astrocytic activities. Brain Res. 1991 Dec 20; 567(2):253-9. PMID: 1687807.
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    34. Lampert-Etchells M, McNeill TH, Laping NJ, Zarow C, Finch CE, May PC. Sulfated glycoprotein-2 is increased in rat hippocampus following entorhinal cortex lesioning. Brain Res. 1991 Nov 01; 563(1-2):101-6. PMID: 1723918.
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    35. Pasinetti GM, Cheng HW, Reinhard JF, Finch CE, McNeill TH. Molecular and morphological correlates following neuronal deafferentation: a cortico-striatal model. Adv Exp Med Biol. 1991; 296:249-55. PMID: 1781331.
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    36. McNeill TH, Masters JN, Finch CE. Effect of chronic adrenalectomy on neuron loss and distribution of sulfated glycoprotein-2 in the dentate gyrus of prepubertal rats. Exp Neurol. 1991 Jan; 111(1):140-4. PMID: 1984431.
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    37. Day JR, Laping NJ, McNeill TH, Schreiber SS, Pasinetti G, Finch CE. Castration enhances expression of glial fibrillary acidic protein and sulfated glycoprotein-2 in the intact and lesion-altered hippocampus of the adult male rat. Mol Endocrinol. 1990 Dec; 4(12):1995-2002. PMID: 2082194.
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    38. McNeill TH, Koek LL, Brown SA, Rafols JA. Quantitative analysis of age-related dendritic changes in medium spiny I (MSI) striatal neurons of C57BL/6N mice. Neurobiol Aging. 1990 Sep-Oct; 11(5):537-50. PMID: 2234285.
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    39. McNeill TH, Koek LL. Differential effects of advancing age on neurotransmitter cell loss in the substantia nigra and striatum of C57BL/6N mice. Brain Res. 1990 Jun 25; 521(1-2):107-17. PMID: 1976411.
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    40. Johnson SA, McNeill T, Cordell B, Finch CE. Relation of neuronal APP-751/APP-695 mRNA ratio and neuritic plaque density in Alzheimer's disease. Science. 1990 May 18; 248(4957):854-7. PMID: 2111579.
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    41. Rafols JA, Cheng HW, McNeill TH. Golgi study of the mouse striatum: age-related dendritic changes in different neuronal populations. J Comp Neurol. 1989 Jan 08; 279(2):212-27. PMID: 2464010.
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    42. McNeill TH, Brown SA, Rafols JA, Shoulson I. Atrophy of medium spiny I striatal dendrites in advanced Parkinson's disease. Brain Res. 1988 Jul 05; 455(1):148-52. PMID: 3416180.
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    43. McNeill TH, Koek LL, Brown SA, Rafols JA. Age-related changes in the nigrostriatal system. Ann N Y Acad Sci. 1988; 515:239-48. PMID: 3364886.
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    44. McNeill TH, Koek LL, Brown SA, Hamill RW, Wu JY. Effect of misonidazole on neurotransmitter systems. Int J Radiat Oncol Biol Phys. 1986 Jul; 12(7):1067-70. PMID: 2875048.
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    45. Armstrong WE, Schöler J, McNeill TH. Immunocytochemical, Golgi and electron microscopic characterization of putative dendrites in the ventral glial lamina of the rat supraoptic nucleus. Neuroscience. 1982 Mar; 7(3):679-94. PMID: 6175923.
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    46. McNeill TH, Sladek JR. Simultaneous monoamine histofluorescence and neuropeptide immunocytochemistry: II. Correlative distribution of catecholamine varicosities and magnocellular neurosecretory neurons in the rat supraoptic and paraventricular nuclei. J Comp Neurol. 1980 Oct 15; 193(4):1023-33. PMID: 7000861.
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    47. Armstrong WE, Warach S, Hatton GI, McNeill TH. Subnuclei in the rat hypothalamic paraventricular nucleus: a cytoarchitectural, horseradish peroxidase and immunocytochemical analysis. Neuroscience. 1980; 5(11):1931-58. PMID: 7432630.
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