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Thomas G Keens, MD

TitleProfessor of Pediatrics
InstitutionUniversity of Southern California
DepartmentPediatrics
AddressCHL Mail Stop 83
Off Campus
Los Angeles CA 90089
Phone+1 323 361 2101
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    Collapse Biography 
    Collapse Awards and Honors
    Listed in The Best Doctors in America
    Board of Directors, American Board of PediatricsSubspecialist representative member
    Fellow of American Academy of Pediatrics and American College of Chest Physicians
    Chair of California Sudden Infant Death Syndrome Advisory Council

    Collapse Overview 
    Collapse Overview
    An expert on respiratory and pulmonary disorders in children, including sudden infant death syndrome


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    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Maloney MA, Kun SS, Keens T, Perez IA. Congenital central hypoventilation syndrome: diagnosis and management. Expert Rev Respir Med. 2018 Apr; 12(4):283-292. PMID: 29486608.
      View in: PubMed
    2. Wang A, Kun S, Diep B, Davidson Ward SL, Keens T, Perez IA. Obstructive Sleep Apnea in Patients With Congenital Central Hypoventilation Syndrome Ventilated by Diaphragm Pacing Without Tracheostomy. J Clin Sleep Med. 2018 Feb 15; 14(2):261-264. PMID: 29351818.
      View in: PubMed
    3. Kasi AS, Jurgensen TJ, Yen S, Kun SS, Keens T, Perez IA. Three-Generation Family With Congenital Central Hypoventilation Syndrome and Novel PHOX2B Gene Non-Polyalanine Repeat Mutation. J Clin Sleep Med. 2017 Jul 15; 13(7):925-927. PMID: 28633714.
      View in: PubMed
    4. Kun S, Placencia G, Ward SD, Keens T. A System Analysis of Delay in Outpatient Respiratory Equipment Delivery. Care Manag J. 2016 Dec 01; 17(4):161-169. PMID: 28914227.
      View in: PubMed
    5. Kasi AS, Perez IA, Kun SS, Keens T. Congenital central hypoventilation syndrome: diagnostic and management challenges. Pediatric Health Med Ther. 2016; 7:99-107. PMID: 29388615.
      View in: PubMed
    6. Edwards JD, Houtrow AJ, Lucas AR, Miller RL, Keens T, Panitch HB, Dudley RA. Children and Young Adults Who Received Tracheostomies or Were Initiated on Long-Term Ventilation in PICUs. Pediatr Crit Care Med. 2016 Aug; 17(8):e324-34. PMID: 27367044.
      View in: PubMed
    7. Salinas DB, Azen C, Young S, Keens T, Kharrazi M, Parad RB. Phenotypes of California CF Newborn Screen-Positive Children with CFTR 5T Allele by TG Repeat Length. Genet Test Mol Biomarkers. 2016 Sep; 20(9):496-503. PMID: 27447098.
      View in: PubMed
    8. Salinas DB, Sosnay PR, Azen C, Young S, Raraigh KS, Keens T, Kharrazi M. Benign and Deleterious Cystic Fibrosis Transmembrane Conductance Regulator Mutations Identified by Sequencing in Positive Cystic Fibrosis Newborn Screen Children from California. PLoS One. 2016; 11(5):e0155624. PMID: 27214204; PMCID: PMC4877015.
    9. Perez IA, Kun S, Keens T. PATIENT EDUCATION | INFORMATION SERIES. Diaphragm Pacing by Phrenic Nerve Stimulation. Am J Respir Crit Care Med. 2016 Apr 15; 193(8):P13-4. PMID: 27082539.
      View in: PubMed
    10. Ackerman MJ, Andrew TA, Baker AM, Devinsky O, Downs JC, Keens T, Kuntz J, Lin P, Lear-Kaul KC, Reichard R, Robinson DA. An Association of Hippocampal Malformations and Sudden Death? We Need More Data. Forensic Sci Med Pathol. 2016 06; 12(2):229-31. PMID: 27017493.
      View in: PubMed
    11. Stastny PF, Keens T, Alkon A. Supporting SIDS Families: The Public Health Nurse SIDS Home Visit. Public Health Nurs. 2016 05; 33(3):242-8. PMID: 26822270.
      View in: PubMed
    12. De A, Mascarenhas L, Kamath S, LaRiviere A, Goodarzian F, Keens T, Venkatramani R. Pilot Feasibility Study of Comprehensive Pulmonary Evaluation Following Lung Radiation Therapy. J Pediatr Hematol Oncol. 2015 Oct; 37(7):e412-8. PMID: 26241727; PMCID: PMC4573838 [Available on 10/01/16].
    13. Bhatia R, Lesser DJ, Oliveira FG, Tran WH, Keens T, Khoo MC, Davidson Ward SL. Body Fat Composition: A Predictive Factor for Sleep Related Breathing Disorder in Obese Children. J Clin Sleep Med. 2015 Sep 15; 11(9):1039-45. PMID: 26094935; PMCID: PMC4543248.
    14. Chin CI, Kohn SL, Keens T, Margetis MF, Kato RM. A physician survey reveals differences in management of idiopathic pulmonary hemosiderosis. Orphanet J Rare Dis. 2015 Aug 20; 10:98. PMID: 26289251; PMCID: PMC4545926.
    15. Diep B, Wang A, Kun S, McComb JG, Shaul DB, Shin CE, Keens T, Perez IA. Diaphragm Pacing without Tracheostomy in Congenital Central Hypoventilation Syndrome Patients. Respiration. 2015; 89(6):534-8. PMID: 25924848.
      View in: PubMed
    16. Salinas DB, Sosnay PR, Azen C, Young S, Raraigh KS, Keens T, Kharrazi M. Benign outcome among positive cystic fibrosis newborn screen children with non-CF-causing variants. J Cyst Fibros. 2015 Nov; 14(6):714-9. PMID: 25824995; PMCID: PMC4587349 [Available on 11/01/16].
    17. Nicholson KJ, Nosanov LB, Bowen KA, Kun SS, Perez IA, Keens T, Shin CE. Thoracoscopic placement of phrenic nerve pacers for diaphragm pacing in congenital central hypoventilation syndrome. J Pediatr Surg. 2015 Jan; 50(1):78-81. PMID: 25598098.
      View in: PubMed
    18. De A, Guryev I, LaRiviere A, Kato R, Wee CP, Mascarenhas L, Keens T, Venkatramani R. Pulmonary function abnormalities in childhood cancer survivors treated with bleomycin. Pediatr Blood Cancer. 2014 Sep; 61(9):1679-84. PMID: 24789770.
      View in: PubMed
    19. Kun SS, Beas VN, Keens T, Ward SS, Gold JI. Examining pediatric emergency home ventilation practices in home health nurses: Opportunities for improved care. Pediatr Pulmonol. 2015 Jul; 50(7):691-7. PMID: 24706404.
      View in: PubMed
    20. De A, Kamath S, Wong K, Olch AJ, Malvar J, Sposto R, Mascarenhas L, Keens T, Venkatramani R. Correlation of pulmonary function abnormalities with dose volume histograms in children treated with lung irradiation. Pediatr Pulmonol. 2015 Jun; 50(6):596-603. PMID: 24644268.
      View in: PubMed
    21. Venkatramani R, Kamath S, Wong K, Olch AJ, Malvar J, Sposto R, Goodarzian F, Freyer DR, Keens T, Mascarenhas L. Pulmonary outcomes in patients with Hodgkin lymphoma treated with involved field radiation. Pediatr Blood Cancer. 2014 Jul; 61(7):1277-81. PMID: 24482138.
      View in: PubMed
    22. Venkatramani R, Kamath S, Wong K, Olch AJ, Malvar J, Sposto R, Goodarzian F, Freyer DR, Keens T, Mascarenhas L. Correlation of clinical and dosimetric factors with adverse pulmonary outcomes in children after lung irradiation. Int J Radiat Oncol Biol Phys. 2013 Aug 01; 86(5):942-8. PMID: 23726005.
      View in: PubMed
    23. Sohn EY, Kato R, Noetzli LJ, Gera A, Coates T, Harmatz P, Keens T, Wood JC. Exercise performance in thalassemia major: correlation with cardiac iron burden. Am J Hematol. 2013 Mar; 88(3):193-7. PMID: 23339082.
      View in: PubMed
    24. Perez IA, Keens T. Peripheral chemoreceptors in congenital central hypoventilation syndrome. Respir Physiol Neurobiol. 2013 Jan 01; 185(1):186-93. PMID: 23099221.
      View in: PubMed
    25. Jassal MS, Yu AM, Bhatia R, Keens T, Davidson Ward SL. Effect of residential proximity to major roadways on cystic fibrosis exacerbations. Int J Environ Health Res. 2013; 23(2):119-31. PMID: 22838501.
      View in: PubMed
    26. Lesser DJ, Bhatia R, Tran WH, Oliveira F, Ortega R, Keens T, Mittelman SD, Khoo MC, Davidson Ward SL. Sleep fragmentation and intermittent hypoxemia are associated with decreased insulin sensitivity in obese adolescent Latino males. Pediatr Res. 2012 Sep; 72(3):293-8. PMID: 22669298; PMCID: PMC3427473.
    27. Edwards JD, Kun SS, Graham RJ, Keens T. End-of-life discussions and advance care planning for children on long-term assisted ventilation with life-limiting conditions. J Palliat Care. 2012; 28(1):21-7. PMID: 22582468; PMCID: PMC3682656.
    28. Kun SS, Edwards JD, Ward SL, Keens T. Hospital readmissions for newly discharged pediatric home mechanical ventilation patients. Pediatr Pulmonol. 2012 Apr; 47(4):409-14. PMID: 21901855; PMCID: PMC3694986.
    29. Yuan HC, Sohn EY, Abouezzeddine T, Mahrer NE, Barber BA, Keens T, Davidson Ward SL, Gold JI. Neurocognitive functioning in children with obstructive sleep apnea syndrome: a pilot study of positive airway pressure therapy. J Pediatr Nurs. 2012 Dec; 27(6):607-13. PMID: 23101726.
      View in: PubMed
    30. Sangkatumvong S, Khoo MC, Kato R, Detterich JA, Bush A, Keens T, Meiselman HJ, Wood JC, Coates TD. Peripheral vasoconstriction and abnormal parasympathetic response to sighs and transient hypoxia in sickle cell disease. Am J Respir Crit Care Med. 2011 Aug 15; 184(4):474-81. PMID: 21616995; PMCID: PMC3175540.
    31. Sohn EY, Noetzli LJ, Gera A, Kato R, Coates TD, Harmatz P, Keens T, Wood JC. Pulmonary function in thalassaemia major and its correlation with body iron stores. Br J Haematol. 2011 Oct; 155(1):102-5. PMID: 21810090; PMCID: PMC3169737.
    32. Edwards JD, Rivanis C, Kun SS, Caughey AB, Keens T. Costs of hospitalized ventilator-dependent children: differences between a ventilator ward and intensive care unit. Pediatr Pulmonol. 2011 Apr; 46(4):356-61. PMID: 21438169.
      View in: PubMed
    33. Edwards JD, Kun SS, Keens T. Outcomes and causes of death in children on home mechanical ventilation via tracheostomy: an institutional and literature review. J Pediatr. 2010 Dec; 157(6):955-959.e2. PMID: 20713294.
      View in: PubMed
    34. Edwards JD, Kun SS, Keens T, Khemani RG, Moromisato DY. Children with corrected or palliated congenital heart disease on home mechanical ventilation. Pediatr Pulmonol. 2010 Jul; 45(7):645-9. PMID: 20575088.
      View in: PubMed
    35. Weese-Mayer DE, Berry-Kravis EM, Ceccherini I, Keens T, Loghmanee DA, Trang H. An official ATS clinical policy statement: Congenital central hypoventilation syndrome: genetic basis, diagnosis, and management. Am J Respir Crit Care Med. 2010 Mar 15; 181(6):626-44. PMID: 20208042.
      View in: PubMed
    36. Kun SS, Davidson-Ward SL, Hulse LM, Keens T. How much do primary care givers know about tracheostomy and home ventilator emergency care? Pediatr Pulmonol. 2010 Mar; 45(3):270-4. PMID: 20146395.
      View in: PubMed
    37. Lesser DJ, Fleming MM, Maher CA, Kim SB, Woo MS, Keens T. Does the 6-min walk test correlate with the exercise stress test in children? Pediatr Pulmonol. 2010 Feb; 45(2):135-40. PMID: 20082339.
      View in: PubMed
    38. Kun WW, Kun SS, Keens T. Do sequential chest radiographs prompt changes in therapy for home mechanical ventilation children admitted for pneumonia? Care Manag J. 2010; 11(4):217-9. PMID: 21197927.
      View in: PubMed
    39. Keens T. Postdoctoral fellowship training in pediatric pulmonology in the United States of America. Paediatr Respir Rev. 2010 Mar; 11(1):66-7. PMID: 20113996.
      View in: PubMed
    40. Chaicharn J, Lin Z, Chen ML, Ward SL, Keens T, Khoo MC. Model-based assessment of cardiovascular autonomic control in children with obstructive sleep apnea. Sleep. 2009 Jul; 32(7):927-38. PMID: 19639756; PMCID: PMC2706908.
    41. Lesser DJ, Ward SL, Kun SS, Keens T. Congenital hypoventilation syndromes. Semin Respir Crit Care Med. 2009 Jun; 30(3):339-47. PMID: 19452394.
      View in: PubMed
    42. Chang RK, Keens T, Rodriguez S, Chen AY. Sudden infant death syndrome: changing epidemiologic patterns in California 1989-2004. J Pediatr. 2008 Oct; 153(4):498-502. PMID: 18534214.
      View in: PubMed
    43. Tablizo MA, Jacinto P, Parsley D, Chen ML, Ramanathan R, Keens T. Supine sleeping position does not cause clinical aspiration in neonates in hospital newborn nurseries. Arch Pediatr Adolesc Med. 2007 May; 161(5):507-10. PMID: 17485629.
      View in: PubMed
    44. Claudius I, Keens T. Do all infants with apparent life-threatening events need to be admitted? Pediatrics. 2007 Apr; 119(4):679-83. PMID: 17403838.
      View in: PubMed
    45. Chen ML, Turkel SB, Jacobson JR, Keens T. Alcohol use in congenital central hypoventilation syndrome. Pediatr Pulmonol. 2006 Mar; 41(3):283-5. PMID: 16429433.
      View in: PubMed
    46. Yuan N, Skaggs DL, Dorey F, Keens T. Preoperative predictors of prolonged postoperative mechanical ventilation in children following scoliosis repair. Pediatr Pulmonol. 2005 Nov; 40(5):414-9. PMID: 16145695.
      View in: PubMed
    47. Yuan N, Fraire JA, Margetis MM, Skaggs DL, Tolo VT, Keens T. The effect of scoliosis surgery on lung function in the immediate postoperative period. Spine (Phila Pa 1976). 2005 Oct 01; 30(19):2182-5. PMID: 16205344.
      View in: PubMed
    48. Chen ML, Tablizo MA, Kun S, Keens T. Diaphragm pacers as a treatment for congenital central hypoventilation syndrome. Expert Rev Med Devices. 2005 Sep; 2(5):577-85. PMID: 16293069.
      View in: PubMed
    49. Kumar R, Macey PM, Woo MA, Alger JR, Keens T, Harper RM. Neuroanatomic deficits in congenital central hypoventilation syndrome. J Comp Neurol. 2005 Jul 11; 487(4):361-71. PMID: 15906312.
      View in: PubMed
    50. Chen ML, Witmans MB, Tablizo MA, Jubran RF, Turkel SB, Tavaré CJ, Keens T. Disordered respiratory control in children with partial cerebellar resections. Pediatr Pulmonol. 2005 Jul; 40(1):88-91. PMID: 15880401.
      View in: PubMed
    51. Macey PM, Macey KE, Woo MA, Keens T, Harper RM. Aberrant neural responses to cold pressor challenges in congenital central hypoventilation syndrome. Pediatr Res. 2005 Apr; 57(4):500-9. PMID: 15718375.
      View in: PubMed
    52. Woo MA, Macey PM, Macey KE, Keens T, Woo MS, Harper RK, Harper RM. FMRI responses to hyperoxia in congenital central hypoventilation syndrome. Pediatr Res. 2005 Apr; 57(4):510-8. PMID: 15718370.
      View in: PubMed
    53. Lynn Chen M, Davidson Ward SL, Keens T, Lin Z, K Khoo M. Cardio-respiratory Uncoupling in Congenital Central Hypoventilation Syndrome. Conf Proc IEEE Eng Med Biol Soc. 2005; 4:4412-5. PMID: 17281214.
      View in: PubMed
    54. Lin Z, K Khoo M, Chen M, Keens T, Davidson Ward SL. Noninvasive assessment of cardiovascular autonomic control in pediatric obstructive sleep apnea syndrome. Conf Proc IEEE Eng Med Biol Soc. 2005; 1:776-9. PMID: 17282299.
      View in: PubMed
    55. Lin Z, K Khoo M, Chen M, Keens T, Davidson Ward SL. Noninvasive assessment of cardiovascular autonomic control in pediatric obstructive sleep apnea syndrome. Conf Proc IEEE Eng Med Biol Soc. 2005; 4:4416-9. PMID: 17281215.
      View in: PubMed
    56. Hamutcu R, Nield TA, Garg M, Keens T, Platzker AC. Long-term pulmonary sequelae in children who were treated with extracorporeal membrane oxygenation for neonatal respiratory failure. Pediatrics. 2004 Nov; 114(5):1292-6. PMID: 15520110.
      View in: PubMed
    57. Yuan N, Skaggs DL, Davidson Ward SL, Platzker AC, Keens T. Preoperative polysomnograms and infant pulmonary function tests do not predict prolonged postoperative mechanical ventilation in children following scoliosis repair. Pediatr Pulmonol. 2004 Sep; 38(3):256-60. PMID: 15274107.
      View in: PubMed
    58. Chen ML, Keens T. Congenital central hypoventilation syndrome: not just another rare disorder. Paediatr Respir Rev. 2004 Sep; 5(3):182-9. PMID: 15276129.
      View in: PubMed
    59. Krous HF, Beckwith JB, Byard RW, Rognum TO, Bajanowski T, Corey T, Cutz E, Hanzlick R, Keens T, Mitchell EA. Sudden infant death syndrome and unclassified sudden infant deaths: a definitional and diagnostic approach. Pediatrics. 2004 Jul; 114(1):234-8. PMID: 15231934.
      View in: PubMed
    60. Macey PM, Valderama C, Kim AH, Woo MA, Gozal D, Keens T, Harper RK, Harper RM. Temporal trends of cardiac and respiratory responses to ventilatory challenges in congenital central hypoventilation syndrome. Pediatr Res. 2004 Jun; 55(6):953-9. PMID: 15028846.
      View in: PubMed
    61. Stastny PF, Ichinose TY, Thayer SD, Olson RJ, Keens T. Infant sleep positioning by nursery staff and mothers in newborn hospital nurseries. Nurs Res. 2004 Mar-Apr; 53(2):122-9. PMID: 15084997.
      View in: PubMed
    62. Witmans MB, Keens T, Davidson Ward SL, Marcus CL. Obstructive hypopneas in children and adolescents: normal values. Am J Respir Crit Care Med. 2003 Dec 15; 168(12):1540. PMID: 14668259.
      View in: PubMed
    63. Ner Z, Ross LA, Horn MV, Keens T, MacLaughlin EF, Starnes VA, Woo MS. Bordetella bronchiseptica infection in pediatric lung transplant recipients. Pediatr Transplant. 2003 Oct; 7(5):413-7. PMID: 14738306.
      View in: PubMed
    64. Sritippayawan S, Keens T, Horn MV, Starnes VA, Woo MS. What are the best pulmonary function test parameters for early detection of post-lung transplant bronchiolitis obliterans syndrome in children? Pediatr Transplant. 2003 Jun; 7(3):200-3. PMID: 12756044.
      View in: PubMed
    65. Sritippayawan S, Kun SS, Keens T, Davidson Ward SL. Initiation of home mechanical ventilation in children with neuromuscular diseases. J Pediatr. 2003 May; 142(5):481-5. PMID: 12756377.
      View in: PubMed
    66. Sritippayawan S, Keens T, Horn MV, MacLaughlin EF, Barr ML, Starnes VA, Woo MS. Does lung growth occur when mature lobes are transplanted into children? Pediatr Transplant. 2002 Dec; 6(6):500-4. PMID: 12453203.
      View in: PubMed
    67. Sritippayawan S, Hamutcu R, Kun SS, Ner Z, Ponce M, Keens T. Mother-daughter transmission of congenital central hypoventilation syndrome. Am J Respir Crit Care Med. 2002 Aug 01; 166(3):367-9. PMID: 12153972.
      View in: PubMed
    68. Shaul DB, Danielson PD, McComb JG, Keens T. Thoracoscopic placement of phrenic nerve electrodes for diaphragmatic pacing in children. J Pediatr Surg. 2002 Jul; 37(7):974-8; discussion 974-8. PMID: 12077752.
      View in: PubMed
    69. Nakamura CT, Ng GY, Paton JY, Keens T, Witmer JC, Bautista-Bolduc D, Woo MS. Correlation between digital clubbing and pulmonary function in cystic fibrosis. Pediatr Pulmonol. 2002 May; 33(5):332-8. PMID: 11948977.
      View in: PubMed
    70. Keens T, Oki GS, Gilsanz V, Roe TF, Goodman W, Tsang RC, Specker BL, Saenger EL. Does radiation research in healthy children pose greater than minimal risk? IRB. 1994 Sep-Oct; 16(5):5-10. PMID: 11652793.
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    71. Buckingham BA, Uitto J, Sandborg C, Keens T, Roe T, Costin G, Kaufman F, Bernstein B, Landing B, Castellano A. Scleroderma-like changes in insulin-dependent diabetes mellitus: clinical and biochemical studies. Diabetes Care. 1984 Mar-Apr; 7(2):163-9. PMID: 6734383.
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