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Terence David Sanger, MD, PhD

TitleProfessor of Biomedical Engineering
InstitutionUniversity of Southern California
DepartmentMedical Device Development Facility
AddressDRB 140
University Park Campus
Los Angeles CA 90089-1111
Phone+1 323 300 5970
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    Collapse Research 
    Collapse Research Activities and Funding
    Multiscale models of neural population control in spinal cord
    NIH/NIBIB U01EB021921Jul 1, 2016 - Jun 30, 2020
    Role: Principal Investigator
    Multi-center trial of Augmented Sensory Feedback in Children with Dyskinetic CP
    NIH/NICHD R01HD081346Apr 1, 2015 - Jan 31, 2020
    Role: Principal Investigator
    High-speed simulation of developmental motor disorders
    NIH/NINDS R01NS069214Feb 1, 2010 - Dec 31, 2014
    Role: Principal Investigator
    Optimizing communication devices for children with dyskinetic cerebral palsy
    NIH/NINDS R01NS064046Jul 1, 2009 - Apr 30, 2014
    Role: Principal Investigator
    Taskforce on Childhood Motor Disorders
    NIH/NINDS U13NS061384Sep 30, 2007 - Aug 31, 2013
    Role: Principal Investigator
    Failure of Motor Learning in Childhood Dystonia
    NIH/NINDS R01NS052236Jul 15, 2006 - Feb 28, 2012
    Role: Principal Investigator
    Neural control of abnormal movement
    NIH/NINDS R13NS055614Apr 1, 2006 - May 31, 2008
    Role: Principal Investigator
    Childhood Motor Impairment and Assisted Communication
    NIH/NINDS R21NS045638May 1, 2003 - Apr 30, 2006
    Role: Principal Investigator
    NIH Task Force on Childhood Motor Disorders
    NIH/NINDS U13NS043180Sep 1, 2002 - Aug 31, 2008
    Role: Principal Investigator
    Arm Kinematics in Hyperkinetic Cerebral Palsy
    NIH/NINDS K23NS041243Jul 15, 2001 - Jun 30, 2006
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Sanger TD, Robison A, Arguelles E, Ferman D, Liker M. Case Report: Targeting for Deep Brain Stimulation Surgery Using Chronic Recording and Stimulation in an Inpatient Neuromodulation Monitoring Unit, With Implantation of Electrodes in GPi and Vim in a 7-Year-Old Child With Progressive Generalized Dystonia. J Child Neurol. 2018 Aug 01; 883073818787741. PMID: 30066598.
      View in: PubMed
    2. Sanger TD, Liker M, Arguelles E, Deshpande R, Maskooki A, Ferman D, Tongol A, Robison A. Pediatric Deep Brain Stimulation Using Awake Recording and Stimulation for Target Selection in an Inpatient Neuromodulation Monitoring Unit. Brain Sci. 2018 Jul 17; 8(7). PMID: 30018276.
      View in: PubMed
    3. Bertucco M, Sanger TD. A Model to Estimate the Optimal Layout for Assistive Communication Touchscreen Devices in Children With Dyskinetic Cerebral Palsy. IEEE Trans Neural Syst Rehabil Eng. 2018 Jul; 26(7):1371-1380. PMID: 29985146.
      View in: PubMed
    4. Lin PT, Ross EK, Chidester P, Rosenbluth KH, Hamner SR, Wong SH, Sanger TD, Hallett M, Delp SL. Noninvasive neuromodulation in essential tremor demonstrates relief in a sham-controlled pilot trial. Mov Disord. 2018 Apr 17. PMID: 29663525.
      View in: PubMed
    5. Sanger TD. Basic and Translational Neuroscience of Childhood-Onset Dystonia: A Control-Theory Perspective. Annu Rev Neurosci. 2018 Feb 28. PMID: 29490197.
      View in: PubMed
    6. Borish CN, Feinman AM, Bertucco M, Ramsy NG, Sanger TD. Comparison of speed-accuracy tradeoff between linear and non-linear filtering algorithms for myocontrol. J Neurophysiol. 2018 Jan 31. PMID: 29384451.
      View in: PubMed
    7. Lunardini F, Casellato C, Bertucco M, Sanger TD, Pedrocchi A. Children With and Without Dystonia Share Common Muscle Synergies While Performing Writing Tasks. Ann Biomed Eng. 2017 08; 45(8):1949-1962. PMID: 28560552.
      View in: PubMed
    8. Lytton WW, Arle J, Bobashev G, Ji S, Klassen TL, Marmarelis VZ, Schwaber J, Sherif MA, Sanger TD. Multiscale modeling in the clinic: diseases of the brain and nervous system. Brain Inform. 2017 Dec; 4(4):219-230. PMID: 28488252.
      View in: PubMed
    9. Jalaleddini K, Minos Niu C, Chakravarthi Raja S, Joon Sohn W, Loeb GE, Sanger TD, Valero-Cuevas FJ. Neuromorphic meets neuromechanics, part II: the role of fusimotor drive. J Neural Eng. 2017 Apr; 14(2):025002. PMID: 28094764.
      View in: PubMed
    10. Niu CM, Jalaleddini K, Sohn WJ, Rocamora J, Sanger TD, Valero-Cuevas FJ. Neuromorphic meets neuromechanics, part I: the methodology and implementation. J Neural Eng. 2017 Apr; 14(2):025001. PMID: 28084217.
      View in: PubMed
    11. Koy A, Lin JP, Sanger TD, Marks WA, Mink JW, Timmermann L. Management of movement disorders in children - Authors' reply. Lancet Neurol. 2016 Dec; 15(13):1302-1303. PMID: 27839637.
      View in: PubMed
    12. Liyanagamage SA, Bertucco M, Bhanpuri NH, Sanger TD. Scaled Vibratory Feedback Can Bias Muscle Use in Children With Dystonia During a Redundant, 1-Dimensional Myocontrol Task. J Child Neurol. 2017 02; 32(2):161-169. PMID: 27798370.
      View in: PubMed
    13. Sohn WJ, Niu CM, Sanger TD. A neuromorphic model of motor overflow in focal hand dystonia due to correlated sensory input. J Neural Eng. 2016 10; 13(5):055001. PMID: 27578228.
      View in: PubMed
    14. Marks W, Bailey L, Sanger TD. PEDiDBS: The pediatric international deep brain stimulation registry project. Eur J Paediatr Neurol. 2017 Jan; 21(1):218-222. PMID: 27375173.
      View in: PubMed
    15. Neymotin SA, Dura-Bernal S, Lakatos P, Sanger TD, Lytton WW. Multitarget Multiscale Simulation for Pharmacological Treatment of Dystonia in Motor Cortex. Front Pharmacol. 2016; 7:157. PMID: 27378922; PMCID: PMC4906029.
    16. Koy A, Lin JP, Sanger TD, Marks WA, Mink JW, Timmermann L. Advances in management of movement disorders in children. Lancet Neurol. 2016 Jun; 15(7):719-735. PMID: 27302239.
      View in: PubMed
    17. Chu VW, Park SW, Sanger TD, Sternad D. Children With Dystonia Can Learn a Novel Motor Skill: Strategies That are Tolerant to High Variability. IEEE Trans Neural Syst Rehabil Eng. 2016 Aug; 24(8):847-858. PMID: 26829795.
      View in: PubMed
    18. Bertucco M, Bhanpuri NH, Sanger TD. Perceived Cost and Intrinsic Motor Variability Modulate the Speed-Accuracy Trade-Off. PLoS One. 2015; 10(10):e0139988. PMID: 26447874; PMCID: PMC4598106.
    19. Lunardini F, Casellato C, d'Avella A, Sanger TD, Pedrocchi A. Robustness and Reliability of Synergy-Based Myocontrol of a Multiple Degree of Freedom Robotic Arm. IEEE Trans Neural Syst Rehabil Eng. 2016 09; 24(9):940-950. PMID: 26441423.
      View in: PubMed
    20. Ghoreyshi A, Sanger TD. A Nonlinear Stochastic Filter for Continuous-Time State Estimation. IEEE Trans Automat Contr. 2015 Aug; 60(8):2161-2165. PMID: 26412871.
      View in: PubMed
    21. Lunardini F, Maggioni S, Casellato C, Bertucco M, Pedrocchi AL, Sanger TD. Increased task-uncorrelated muscle activity in childhood dystonia. J Neuroeng Rehabil. 2015 Jun 12; 12:52. PMID: 26068444; PMCID: PMC4464613.
    22. Sohn WJ, Niu CM, Sanger TD. Increased long-latency reflex activity as a sufficient explanation for childhood hypertonic dystonia: a neuromorphic emulation study. J Neural Eng. 2015 Jun; 12(3):036010. PMID: 25946372; PMCID: PMC4475677.
    23. Dunning A, Ghoreyshi A, Bertucco M, Sanger TD. The tuning of human motor response to risk in a dynamic environment task. PLoS One. 2015; 10(4):e0125461. PMID: 25901604.
      View in: PubMed
    24. Lunardini F, Bertucco M, Casellato C, Bhanpuri N, Pedrocchi A, Sanger TD. Speed-Accuracy Trade-Off in a Trajectory-Constrained Self-Feeding Task: A Quantitative Index of Unsuppressed Motor Noise in Children With Dystonia. J Child Neurol. 2015 Oct; 30(12):1676-85. PMID: 25895910; PMCID: PMC4575821 [Available on 10/01/16].
    25. Bhanpuri NH, Bertucco M, Young SJ, Lee AA, Sanger TD. Multiday Transcranial Direct Current Stimulation Causes Clinically Insignificant Changes in Childhood Dystonia: A Pilot Study. J Child Neurol. 2015 Oct; 30(12):1604-15. PMID: 25792428.
      View in: PubMed
    26. Niu CM, Lee K, Houde JF, Sanger TD. Vowel generation for children with cerebral palsy using myocontrol of a speech synthesizer. Front Hum Neurosci. 2014; 8:1077. PMID: 25657622; PMCID: PMC4302943.
    27. Lunardini F, Casellato C, Bertucco M, Sanger TD, Pedrocchi A. Muscle synergies in children with dystonia capture "healthy" patterns regardless the altered motor performance. Conf Proc IEEE Eng Med Biol Soc. 2015; 2015:2099-102. PMID: 26736702.
      View in: PubMed
    28. Niu CM, Nandyala SK, Sanger TD. Emulated muscle spindle and spiking afferents validates VLSI neuromorphic hardware as a testbed for sensorimotor function and disease. Front Comput Neurosci. 2014; 8:141. PMID: 25538613; PMCID: PMC4255602.
    29. Bertucco M, Sanger TD. Current and emerging strategies for treatment of childhood dystonia. J Hand Ther. 2015 Apr-Jun; 28(2):185-93; quiz 194. PMID: 25835254; PMCID: PMC4424089.
    30. Sanger TD. Risk-aware control. Neural Comput. 2014 Dec; 26(12):2669-91. PMID: 25149696.
      View in: PubMed
    31. Bhanpuri NH, Bertucco M, Ferman D, Young SJ, Liker MA, Krieger MD, Sanger TD. Deep brain stimulation evoked potentials may relate to clinical benefit in childhood dystonia. Brain Stimul. 2014 Sep-Oct; 7(5):718-26. PMID: 25088460.
      View in: PubMed
    32. Chu VW, Sanger TD. Two different motor learning mechanisms contribute to learning reaching movements in a rotated visual environment. F1000Res. 2014; 3:72. PMID: 26673417; PMCID: PMC4670007.
    33. Sanger TD, Kalaska JF. Crouching tiger, hidden dimensions. Nat Neurosci. 2014 Mar; 17(3):338-40. PMID: 24569828.
      View in: PubMed
    34. Olaya JE, Christian E, Ferman D, Luc Q, Krieger MD, Sanger TD, Liker MA. Deep brain stimulation in children and young adults with secondary dystonia: the Children's Hospital Los Angeles experience. Neurosurg Focus. 2013 Nov; 35(5):E7. PMID: 24175867.
      View in: PubMed
    35. Bertucco M, Sanger TD. Speed-accuracy testing on the Apple iPad provides a quantitative test of upper extremity motor performance in children with dystonia. J Child Neurol. 2014 Nov; 29(11):1460-6. PMID: 23965400.
      View in: PubMed
    36. Young SJ, Bertucco M, Sanger TD. Cathodal transcranial direct current stimulation in children with dystonia: a sham-controlled study. J Child Neurol. 2014 Feb; 29(2):232-9. PMID: 23760989.
      View in: PubMed
    37. Chu VW, Sternad D, Sanger TD. Healthy and dystonic children compensate for changes in motor variability. J Neurophysiol. 2013 Apr; 109(8):2169-78. PMID: 23343896; PMCID: PMC3628036.
    38. Young SJ, Bertucco M, Sheehan-Stross R, Sanger TD. Cathodal transcranial direct current stimulation in children with dystonia: a pilot open-label trial. J Child Neurol. 2013 Oct; 28(10):1238-44. PMID: 23034972.
      View in: PubMed
    39. Air EL, Ostrem JL, Sanger TD, Starr PA. Deep brain stimulation in children: experience and technical pearls. J Neurosurg Pediatr. 2011 Dec; 8(6):566-74. PMID: 22132914.
      View in: PubMed
    40. Sanger TD. Distributed control of uncertain systems using superpositions of linear operators. Neural Comput. 2011 Aug; 23(8):1911-34. PMID: 21521040; PMCID: PMC3086813.
    41. Cramer SC, Sur M, Dobkin BH, O'Brien C, Sanger TD, Trojanowski JQ, Rumsey JM, Hicks R, Cameron J, Chen D, Chen WG, Cohen LG, deCharms C, Duffy CJ, Eden GF, Fetz EE, Filart R, Freund M, Grant SJ, Haber S, Kalivas PW, Kolb B, Kramer AF, Lynch M, Mayberg HS, McQuillen PS, Nitkin R, Pascual-Leone A, Reuter-Lorenz P, Schiff N, Sharma A, Shekim L, Stryker M, Sullivan EV, Vinogradov S. Harnessing neuroplasticity for clinical applications. Brain. 2011 Jun; 134(Pt 6):1591-609. PMID: 21482550; PMCID: PMC3102236.
    42. Young SJ, van Doornik J, Sanger TD. Finger muscle control in children with dystonia. Mov Disord. 2011 Jun; 26(7):1290-6. PMID: 21449015; PMCID: PMC3119776.
    43. Kukke SN, Sanger TD. Contributors to excess antagonist activity during movement in children with secondary dystonia due to cerebral palsy. J Neurophysiol. 2011 May; 105(5):2100-7. PMID: 21325680.
      View in: PubMed
    44. Przekop A, Sanger TD. Birth-related syndromes of athetosis and kernicterus. Handb Clin Neurol. 2011; 100:387-95. PMID: 21496597.
      View in: PubMed
    45. Kurian MA, Li Y, Zhen J, Meyer E, Hai N, Christen HJ, Hoffmann GF, Jardine P, von Moers A, Mordekar SR, O'Callaghan F, Wassmer E, Wraige E, Dietrich C, Lewis T, Hyland K, Heales S, Sanger T, Gissen P, Assmann BE, Reith ME, Maher ER. Clinical and molecular characterisation of hereditary dopamine transporter deficiency syndrome: an observational cohort and experimental study. Lancet Neurol. 2011 Jan; 10(1):54-62. PMID: 21112253; PMCID: PMC3002401.
    46. Sanger TD. Controlling variability. J Mot Behav. 2010 Nov; 42(6):401-7. PMID: 21184358.
      View in: PubMed
    47. Sanger TD, Chen D, Fehlings DL, Hallett M, Lang AE, Mink JW, Singer HS, Alter K, Ben-Pazi H, Butler EE, Chen R, Collins A, Dayanidhi S, Forssberg H, Fowler E, Gilbert DL, Gorman SL, Gormley ME, Jinnah HA, Kornblau B, Krosschell KJ, Lehman RK, MacKinnon C, Malanga CJ, Mesterman R, Michaels MB, Pearson TS, Rose J, Russman BS, Sternad D, Swoboda KJ, Valero-Cuevas F. Definition and classification of hyperkinetic movements in childhood. Mov Disord. 2010 Aug 15; 25(11):1538-49. PMID: 20589866; PMCID: PMC2929378.
    48. Young SJ, van Doornik J, Sanger TD. Visual feedback reduces co-contraction in children with dystonia. J Child Neurol. 2011 Jan; 26(1):37-43. PMID: 20525943.
      View in: PubMed
    49. Bloom R, Przekop A, Sanger TD. Prolonged electromyogram biofeedback improves upper extremity function in children with cerebral palsy. J Child Neurol. 2010 Dec; 25(12):1480-4. PMID: 20525944.
      View in: PubMed
    50. Sanger TD. Neuro-mechanical control using differential stochastic operators. Conf Proc IEEE Eng Med Biol Soc. 2010; 2010:4494-7. PMID: 21095779.
      View in: PubMed
    51. Ben-Pazi H, Ishihara A, Kukke S, Sanger TD. Increasing viscosity and inertia using a robotically controlled pen improves handwriting in children. J Child Neurol. 2010 Jun; 25(6):674-80. PMID: 19794098; PMCID: PMC2878373.
    52. Chu WT, Sanger TD. Force variability during isometric biceps contraction in children with secondary dystonia due to cerebral palsy. Mov Disord. 2009 Jul 15; 24(9):1299-305. PMID: 19412940.
      View in: PubMed
    53. van Doornik J, Kukke S, Sanger TD. Hypertonia in childhood secondary dystonia due to cerebral palsy is associated with reflex muscle activation. Mov Disord. 2009 May 15; 24(7):965-71. PMID: 19353733.
      View in: PubMed
    54. Goetz CG, Stebbins GT, Wolff D, DeLeeuw W, Bronte-Stewart H, Elble R, Hallett M, Nutt J, Ramig L, Sanger T, Wu AD, Kraus PH, Blasucci LM, Shamim EA, Sethi KD, Spielman J, Kubota K, Grove AS, Dishman E, Taylor CB. Testing objective measures of motor impairment in early Parkinson's disease: Feasibility study of an at-home testing device. Mov Disord. 2009 Mar 15; 24(4):551-6. PMID: 19086085.
      View in: PubMed
    55. Sanger TD. Is cerebral palsy a wastebasket diagnosis? J Child Neurol. 2008 Jul; 23(7):726-8. PMID: 18658072.
      View in: PubMed
    56. Sanger TD. Use of surface electromyography (EMG) in the diagnosis of childhood hypertonia: a pilot study. J Child Neurol. 2008 Jun; 23(6):644-8. PMID: 18344454; PMCID: PMC2837764.
    57. van Doornik J, Kukke S, McGill K, Rose J, Sherman-Levine S, Sanger TD. Oral baclofen increases maximal voluntary neuromuscular activation of ankle plantar flexors in children with spasticity due to cerebral palsy. J Child Neurol. 2008 Jun; 23(6):635-9. PMID: 18281622.
      View in: PubMed
    58. Sanger TD, Henderson J. Optimizing assisted communication devices for Children with motor impairments using a model of information rate and channel capacity. IEEE Trans Neural Syst Rehabil Eng. 2007 Sep; 15(3):458-68. PMID: 17894279.
      View in: PubMed
    59. Ben-Pazi H, Kukke S, Sanger TD. Poor penmanship in children correlates with abnormal rhythmic tapping: a broad functional temporal impairment. J Child Neurol. 2007 May; 22(5):543-9. PMID: 17690059.
      View in: PubMed
    60. Sanger TD, Bastian A, Brunstrom J, Damiano D, Delgado M, Dure L, Gaebler-Spira D, Hoon A, Mink JW, Sherman-Levine S, Welty LJ. Prospective open-label clinical trial of trihexyphenidyl in children with secondary dystonia due to cerebral palsy. J Child Neurol. 2007 May; 22(5):530-7. PMID: 17690057.
      View in: PubMed
    61. Sanger TD, Kukke SN. Abnormalities of tactile sensory function in children with dystonic and diplegic cerebral palsy. J Child Neurol. 2007 Mar; 22(3):289-93. PMID: 17621498.
      View in: PubMed
    62. Grossman AD, Sanger TD. A probabilistic algorithm for estimating the intention of computer users with movement disorders. Conf Proc IEEE Eng Med Biol Soc. 2007; 2007:3605-8. PMID: 18002777.
      View in: PubMed
    63. Sanger TD, Kukke SN, Sherman-Levine S. Botulinum toxin type B improves the speed of reaching in children with cerebral palsy and arm dystonia: an open-label, dose-escalation pilot study. J Child Neurol. 2007 Jan; 22(1):116-22. PMID: 17608320.
      View in: PubMed
    64. Malfait N, Sanger TD. Does dystonia always include co-contraction? A study of unconstrained reaching in children with primary and secondary dystonia. Exp Brain Res. 2007 Jan; 176(2):206-16. PMID: 16850323.
      View in: PubMed
    65. Sanger TD. Bayesian filtering of myoelectric signals. J Neurophysiol. 2007 Feb; 97(2):1839-45. PMID: 17182908.
      View in: PubMed
    66. Sanger TD, Chen D, Delgado MR, Gaebler-Spira D, Hallett M, Mink JW. Definition and classification of negative motor signs in childhood. Pediatrics. 2006 Nov; 118(5):2159-67. PMID: 17079590.
      View in: PubMed
    67. Sanger TD. Arm trajectories in dyskinetic cerebral palsy have increased random variability. J Child Neurol. 2006 Jul; 21(7):551-7. PMID: 16970842.
      View in: PubMed
    68. Sanger TD. Hypertonia in children: how and when to treat. Curr Treat Options Neurol. 2005 Nov; 7(6):427-39. PMID: 16221366.
      View in: PubMed
    69. Sanger TD, Kaiser J, Placek B. Reaching movements in childhood dystonia contain signal-dependent noise. J Child Neurol. 2005 Jun; 20(6):489-96. PMID: 15996397.
      View in: PubMed
    70. Sanger TD. Toward a definition of childhood dystonia. Curr Opin Pediatr. 2004 Dec; 16(6):623-7. PMID: 15548923.
      View in: PubMed
    71. Sanger TD. Failure of motor learning for large initial errors. Neural Comput. 2004 Sep; 16(9):1873-86. PMID: 15265326.
      View in: PubMed
    72. Sanger TD. Severe resting clonus caused by thyrotoxicosis in a 16-year-old girl with hereditary spastic paraparesis: a case report. Mov Disord. 2004 Jun; 19(6):712-3. PMID: 15197716.
      View in: PubMed
    73. Sanger TD. Pathophysiology of pediatric movement disorders. J Child Neurol. 2003 Sep; 18 Suppl 1:S9-24. PMID: 13677568.
      View in: PubMed
    74. Sanger TD. Pediatric movement disorders. Curr Opin Neurol. 2003 Aug; 16(4):529-35. PMID: 12869814.
      View in: PubMed
    75. Thelen DD, Riewald SA, Asakawa DS, Sanger TD, Delp SL. Abnormal coupling of knee and hip moments during maximal exertions in persons with cerebral palsy. Muscle Nerve. 2003 Apr; 27(4):486-93. PMID: 12661051.
      View in: PubMed
    76. Sanger TD. Neural population codes. Curr Opin Neurobiol. 2003 Apr; 13(2):238-49. PMID: 12744980.
      View in: PubMed
    77. Sanger TD, Delgado MR, Gaebler-Spira D, Hallett M, Mink JW. Classification and definition of disorders causing hypertonia in childhood. Pediatrics. 2003 Jan; 111(1):e89-97. PMID: 12509602.
      View in: PubMed
    78. Sanger TD. Decoding neural spike trains: calculating the probability that a spike train and an external signal are related. J Neurophysiol. 2002 Mar; 87(3):1659-63. PMID: 11877538.
      View in: PubMed
    79. Sanger TD, Pascual-Leone A, Tarsy D, Schlaug G. Nonlinear sensory cortex response to simultaneous tactile stimuli in writer's cramp. Mov Disord. 2002 Jan; 17(1):105-11. PMID: 11835446.
      View in: PubMed
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