Takahiro Ohyama, PhD

Title(s)Assistant Professor of Research Otolaryngology-Head and Neck Surgery
SchoolKeck School of Medicine of USC
Phone+1 323 442 4413
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    Collapse Overview 
    Collapse Overview
    Hearing loss is one of the most common birth defects. Approximately one in five hundred newborns suffer from significant hearing impairment. In addition, once mechanosensory hair cells in the inner ear are damaged and lost by any of a variety of reasons such as aging and loud noises, they never regenerate. Thus, majority of sensorineural hearing loss, such as age-related hearing loss and noise-induced hearing loss is permanent and significantly affect the quality of one?s life. Recently, stem cell research has shed light on the possibility of regeneration of hair cells in humans. Our research goal is to understand the molecular mechanisms of inner ear development and to explore the possibility of regenerating sensory cells to treat hearing and balance disorders.

    Collapse Research 
    Collapse Research Activities and Funding
    Developmental patterning of the cochlea
    NIH/NIDCD R01DC012085Jan 3, 2013 - Dec 31, 2017
    Role: Principal Investigator
    The function of Foxi3 in craniofacial development
    NIH/NIDCD R03DC007349Jan 12, 2006 - Nov 30, 2009
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Salehi P, Ge MX, Gundimeda U, Michelle Baum L, Lael Cantu H, Lavinsky J, Tao L, Myint A, Cruz C, Wang J, Nikolakopoulou AM, Abdala C, Kelley MW, Ohyama T, Coate TM, Friedman RA. Role of Neuropilin-1/Semaphorin-3A signaling in the functional and morphological integrity of the cochlea. PLoS Genet. 2017 Oct; 13(10):e1007048. PMID: 29059194.
      View in: PubMed
    2. Salehi P, Myint A, Kim YJ, Ge MX, Lavinsky J, Ho MK, Crow AL, Cruz C, Monges-Hernadez M, Wang J, Hartiala J, Zhang LI, Allayee H, Lusis AJ, Ohyama T, Friedman RA. Genome-Wide Association Analysis Identifies Dcc as an Essential Factor in the Innervation of the Peripheral Vestibular System in Inbred Mice. J Assoc Res Otolaryngol. 2016 Oct; 17(5):417-31. PMID: 27539716; PMCID: PMC5023540 [Available on 10/01/17].
    3. Shibata S, Miwa T, Wu HH, Levitt P, Ohyama T. Hepatocyte Growth Factor-c-MET Signaling Mediates the Development of Nonsensory Structures of the Mammalian Cochlea and Hearing. J Neurosci. 2016 08 03; 36(31):8200-9. PMID: 27488639; PMCID: PMC4971366 [Available on 02/03/17].
    4. Shirokova V, Biggs LC, Jussila M, Ohyama T, Groves AK, Mikkola ML. Foxi3 Deficiency Compromises Hair Follicle Stem Cell Specification and Activation. Stem Cells. 2016 07; 34(7):1896-908. PMID: 26992132.
      View in: PubMed
    5. Myint A, White CH, Ohmen JD, Li X, Wang J, Lavinsky J, Salehi P, Crow AL, Ohyama T, Friedman RA. Large-scale phenotyping of noise-induced hearing loss in 100 strains of mice. Hear Res. 2016 Feb; 332:113-120. PMID: 26706709; PMCID: PMC4769955 [Available on 02/01/17].
    6. Birol O, Ohyama T, Edlund RK, Drakou K, Georgiades P, Groves AK. The mouse Foxi3 transcription factor is necessary for the development of posterior placodes. Dev Biol. 2016 Jan 01; 409(1):139-151. PMID: 26550799.
      View in: PubMed
    7. Jussila M, Aalto AJ, Sanz Navarro M, Shirokova V, Balic A, Kallonen A, Ohyama T, Groves AK, Mikkola ML, Thesleff I. Suppression of epithelial differentiation by Foxi3 is essential for molar crown patterning. Development. 2015 Nov 15; 142(22):3954-63. PMID: 26450968.
      View in: PubMed
    8. Urness LD, Wang X, Shibata S, Ohyama T, Mansour SL. Fgf10 is required for specification of non-sensory regions of the cochlear epithelium. Dev Biol. 2015 Apr 01; 400(1):59-71. PMID: 25624266; PMCID: PMC4361244.
    9. Edlund RK, Ohyama T, Kantarci H, Riley BB, Groves AK. Foxi transcription factors promote pharyngeal arch development by regulating formation of FGF signaling centers. Dev Biol. 2014 Jun 01; 390(1):1-13. PMID: 24650709; PMCID: PMC4013273.
    10. Basch ML, Ohyama T, Segil N, Groves AK. Canonical Notch signaling is not necessary for prosensory induction in the mouse cochlea: insights from a conditional mutant of RBPjkappa. J Neurosci. 2011 Jun 01; 31(22):8046-58. PMID: 21632926; PMCID: PMC3112354.
    11. Reginensi A, Clarkson M, Neirijnck Y, Lu B, Ohyama T, Groves AK, Sock E, Wegner M, Costantini F, Chaboissier MC, Schedl A. SOX9 controls epithelial branching by activating RET effector genes during kidney development. Hum Mol Genet. 2011 Mar 15; 20(6):1143-53. PMID: 21212101; PMCID: PMC3809456.
    12. Ohyama T, Basch ML, Mishina Y, Lyons KM, Segil N, Groves AK. BMP signaling is necessary for patterning the sensory and nonsensory regions of the developing mammalian cochlea. J Neurosci. 2010 Nov 10; 30(45):15044-51. PMID: 21068310; PMCID: PMC3074492.
    13. Ohyama T. Unraveling inner ear induction by gene manipulation using Pax2-Cre BAC transgenic mice. Brain Res. 2009 Jun 24; 1277:84-9. PMID: 19265685.
      View in: PubMed
    14. Doetzlhofer A, Basch ML, Ohyama T, Gessler M, Groves AK, Segil N. Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti. Dev Cell. 2009 Jan; 16(1):58-69. PMID: 19154718; PMCID: PMC2696015.
    15. Jayasena CS, Ohyama T, Segil N, Groves AK. Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode. Development. 2008 Jul; 135(13):2251-61. PMID: 18495817; PMCID: PMC2575054.
    16. Ohyama T, Groves AK, Martin K. The first steps towards hearing: mechanisms of otic placode induction. Int J Dev Biol. 2007; 51(6-7):463-72. PMID: 17891709.
      View in: PubMed
    17. Arnold JS, Braunstein EM, Ohyama T, Groves AK, Adams JC, Brown MC, Morrow BE. Tissue-specific roles of Tbx1 in the development of the outer, middle and inner ear, defective in 22q11DS patients. Hum Mol Genet. 2006 May 15; 15(10):1629-39. PMID: 16600992; PMCID: PMC2563157.
    18. Ohyama T, Mohamed OA, Taketo MM, Dufort D, Groves AK. Wnt signals mediate a fate decision between otic placode and epidermis. Development. 2006 Mar; 133(5):865-75. PMID: 16452098.
      View in: PubMed
    19. Narita T, Sasaoka S, Udagawa K, Ohyama T, Wada N, Nishimatsu S, Takada S, Nohno T. Wnt10a is involved in AER formation during chick limb development. Dev Dyn. 2005 Jun; 233(2):282-7. PMID: 15789446.
      View in: PubMed
    20. Ohyama T, Groves AK. Expression of mouse Foxi class genes in early craniofacial development. Dev Dyn. 2004 Nov; 231(3):640-6. PMID: 15376323.
      View in: PubMed
    21. Ohyama T, Groves AK. Generation of Pax2-Cre mice by modification of a Pax2 bacterial artificial chromosome. Genesis. 2004 Apr; 38(4):195-9. PMID: 15083520.
      View in: PubMed