Tai-Lan Tuan, PhD

Title(s)Research Associate Professor of Surgery (Part-Time)
SchoolKeck School of Medicine of USC
Phone+1 323 361 4183
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    Collapse Research 
    Collapse Research Activities and Funding
    siRNA Inhibition of Keloid Fibrosis in Fibrin Matrix Skin Equivalent Mouse Models
    NIH/NIGMS R01GM095821Apr 2, 2012 - Feb 29, 2016
    Role: Principal Investigator
    ECM Remodeling in Excessive Fibroplasia
    NIH/NIGMS R01GM055081Jul 1, 1998 - Aug 31, 2012
    Role: Co-Principal Investigator
    NIH/NIAMS R29AR040409Jan 1, 1991 - Dec 31, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Plikus MV, Guerrero-Juarez CF, Ito M, Li YR, Dedhia PH, Zheng Y, Shao M, Gay DL, Ramos R, Hsi TC, Oh JW, Wang X, Ramirez A, Konopelski SE, Elzein A, Wang A, Supapannachart RJ, Lee HL, Lim CH, Nace A, Guo A, Treffeisen E, Andl T, Ramirez RN, Murad R, Offermanns S, Metzger D, Chambon P, Widgerow AD, Tuan TL, Mortazavi A, Gupta RK, Hamilton BA, Millar SE, Seale P, Pear WS, Lazar MA, Cotsarelis G. Regeneration of fat cells from myofibroblasts during wound healing. Science. 2017 02 17; 355(6326):748-752. PMID: 28059714.
      View in: PubMed
    2. Chao TF, Lip GY, Liu CJ, Tuan TC, Chen SJ, Wang KL, Lin YJ, Chang SL, Lo LW, Hu YF, Chen TJ, Chiang CE, Chen SA. Validation of a Modified CHA2DS2-VASc Score for Stroke Risk Stratification in Asian Patients With Atrial Fibrillation: A Nationwide Cohort Study. Stroke. 2016 10; 47(10):2462-9. PMID: 27625386.
      View in: PubMed
    3. Hsueh YY, Wang DH, Huang TC, Chang YJ, Shao WC, Tuan TL, Hughes MW, Wu CC. Novel skin chamber for rat ischemic flap studies in regenerative wound repair. Stem Cell Res Ther. 2016 May 17; 7(1):72. PMID: 27188874; PMCID: PMC4869367.
    4. Lee YS, Hsu T, Chiu WC, Sarkozy H, Kulber DA, Choi A, Kim EW, Benya PD, Tuan TL. Keloid-derived, plasma/fibrin-based skin equivalents generate de novo dermal and epidermal pathology of keloid fibrosis in a mouse model. Wound Repair Regen. 2016 03; 24(2):302-16. PMID: 26683740.
      View in: PubMed
    5. Yang CC, Sheu HM, Chung PL, Chang CH, Tsai YS, Hughes MW, Tuan TL, Huang LL. Leptin of dermal adipose tissue is differentially expressed during the hair cycle and contributes to adipocyte-mediated growth inhibition of anagen-phase vibrissa hair. Exp Dermatol. 2015 Jan; 24(1):57-60. PMID: 25313970.
      View in: PubMed
    6. Chi PC, Lin YJ, Chang SL, Lo LW, Hu YF, Chao TF, Chung FP, Liao J, Tuan TC, Kuo JY, Huang JL, Chen SA. Unipolar peak-negative voltage as an endocardial electrographic characteristic to predict overlying abnormal epicardial substrates in patients with right epicardial ventricular tachycardia. J Cardiovasc Electrophysiol. 2014 Dec; 25(12):1343-9. PMID: 25066314.
      View in: PubMed
    7. Wu L, Gonzalez S, Shah S, Kyupelyan L, Petrigliano FA, McAllister DR, Adams JS, Karperien M, Tuan TL, Benya PD, Evseenko D. Extracellular matrix domain formation as an indicator of chondrocyte dedifferentiation and hypertrophy. Tissue Eng Part C Methods. 2014 Feb; 20(2):160-8. PMID: 23758619; PMCID: PMC3910562.
    8. Lee YS, Wysocki A, Warburton D, Tuan TL. Wound healing in development. Birth Defects Res C Embryo Today. 2012 Sep; 96(3):213-22. PMID: 23109317; PMCID: PMC3678537.
    9. Lien CL, Harrison MR, Tuan TL, Starnes VA. Heart repair and regeneration: recent insights from zebrafish studies. Wound Repair Regen. 2012 Sep-Oct; 20(5):638-46. PMID: 22818295; PMCID: PMC3445789.
    10. Kim J, Rubin N, Huang Y, Tuan TL, Lien CL. In vitro culture of epicardial cells from adult zebrafish heart on a fibrin matrix. Nat Protoc. 2012 Jan 19; 7(2):247-55. PMID: 22262006; PMCID: PMC3541820.
    11. Jiang TX, Tuan TL, Wu P, Widelitz RB, Chuong CM. From buds to follicles: matrix metalloproteinases in developmental tissue remodeling during feather morphogenesis. Differentiation. 2011 Jun; 81(5):307-14. PMID: 21497985; PMCID: PMC3114260.
    12. Kim J, Wu Q, Zhang Y, Wiens KM, Huang Y, Rubin N, Shimada H, Handin RI, Chao MY, Tuan TL, Starnes VA, Lien CL. PDGF signaling is required for epicardial function and blood vessel formation in regenerating zebrafish hearts. Proc Natl Acad Sci U S A. 2010 Oct 05; 107(40):17206-10. PMID: 20858732; PMCID: PMC2951463.
    13. Yeh J, Green LM, Jiang TX, Plikus M, Huang E, Chang RN, Hughes MW, Chuong CM, Tuan TL. Accelerated closure of skin wounds in mice deficient in the homeobox gene Msx2. Wound Repair Regen. 2009 Sep-Oct; 17(5):639-48. PMID: 19769717; PMCID: PMC3074593.
    14. Tuan TL, Hwu P, Ho W, Yiu P, Chang R, Wysocki A, Benya PD. Adenoviral overexpression and small interfering RNA suppression demonstrate that plasminogen activator inhibitor-1 produces elevated collagen accumulation in normal and keloid fibroblasts. Am J Pathol. 2008 Nov; 173(5):1311-25. PMID: 18832570; PMCID: PMC2570122.
    15. Dudas M, Wysocki A, Gelpi B, Tuan TL. Memory encoded throughout our bodies: molecular and cellular basis of tissue regeneration. Pediatr Res. 2008 May; 63(5):502-12. PMID: 18427295.
      View in: PubMed
    16. Li WY, Huang EY, Dudas M, Kaartinen V, Warburton D, Tuan TL. Transforming growth factor-beta3 affects plasminogen activator inhibitor-1 expression in fetal mice and modulates fibroblast-mediated collagen gel contraction. Wound Repair Regen. 2006 Sep-Oct; 14(5):516-25. PMID: 17014662.
      View in: PubMed
    17. Messadi DV, Doung HS, Zhang Q, Kelly AP, Tuan TL, Reichenberger E, Le AD. Activation of NFkappaB signal pathways in keloid fibroblasts. Arch Dermatol Res. 2004 Aug; 296(3):125-33. PMID: 15278366.
      View in: PubMed
    18. Zhang Q, Wu Y, Ann DK, Messadi DV, Tuan TL, Kelly AP, Bertolami CN, Le AD. Mechanisms of hypoxic regulation of plasminogen activator inhibitor-1 gene expression in keloid fibroblasts. J Invest Dermatol. 2003 Nov; 121(5):1005-12. PMID: 14708599.
      View in: PubMed
    19. Nien YD, Han YP, Tawil B, Chan LS, Tuan TL, Garner WL. Fibrinogen inhibits fibroblast-mediated contraction of collagen. Wound Repair Regen. 2003 Sep-Oct; 11(5):380-5. PMID: 12950643; PMCID: PMC2430934.
    20. Wu GD, Tuan TL, Bowdish ME, Jin YS, Starnes VA, Cramer DV, Barr ML. Evidence for recipient derived fibroblast recruitment and activation during the development of chronic cardiac allograft rejection. Transplantation. 2003 Aug 15; 76(3):609-14. PMID: 12923453.
      View in: PubMed
    21. Li WY, Chong SS, Huang EY, Tuan TL. Plasminogen activator/plasmin system: a major player in wound healing? Wound Repair Regen. 2003 Jul-Aug; 11(4):239-47. PMID: 12846910.
      View in: PubMed
    22. Tuan TL, Wu H, Huang EY, Chong SS, Laug W, Messadi D, Kelly P, Le A. Increased plasminogen activator inhibitor-1 in keloid fibroblasts may account for their elevated collagen accumulation in fibrin gel cultures. Am J Pathol. 2003 May; 162(5):1579-89. PMID: 12707042; PMCID: PMC1851185.
    23. Huang EY, Wu H, Island ER, Chong SS, Warburton D, Anderson KD, Tuan TL. Differential expression of urokinase-type plasminogen activator and plasminogen activator inhibitor-1 in early and late gestational mouse skin and skin wounds. Wound Repair Regen. 2002 Nov-Dec; 10(6):387-96. PMID: 12453143.
      View in: PubMed