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    Ramakrishnan Gopalakrishan

    TitleResearch Associate
    SchoolKeck School of Medicine of USC
    DepartmentMedicine
    AddressNRT 1450 Biggy St.
    Health Sciences Campus
    Los Angeles California 90033
    Phone+1 323 442 5771
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      Collapse Biography 
      Collapse Awards and Honors
      American Society of Hematology2014Abstract achievement award
      Society for Free Radical Research2008Travel Award
      Indian Council of Medical Research2007Senior Research Fellowship

      Collapse ORNG Applications 
      Collapse Featured Publications
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      Collapse In The News

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Gopalakrishnan R, Matta H, Tolani B, Triche T, Chaudhary PM. Immunomodulatory drugs target IKZF1-IRF4-MYC axis in primary effusion lymphoma in a cereblon-dependent manner and display synergistic cytotoxicity with BRD4 inhibitors. Oncogene. 2016 Apr 07; 35(14):1797-810. PMID: 26119939; PMCID: PMC4486341.
      2. Anandakumar P, Kamaraj S, Jagan S, Ramakrishnan G, Asokkumar S, Naveenkumar C, Raghunandhakumar S, Vanitha MK, Devaki T. The Anticancer Role of Capsaicin in Experimentallyinduced Lung Carcinogenesis. J Pharmacopuncture. 2015 Jun; 18(2):19-25. PMID: 26120484; PMCID: PMC4481395.
      3. Granum S, Sundvold-Gjerstad V, Gopalakrishnan R, Berge T, Koll L, Abrahamsen G, Sørlie M, Spurkland A. The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192. Sci Signal. 2014 Dec 09; 7(355):ra118. PMID: 25492967.
        View in: PubMed
      4. Sundaram J, Keshava S, Gopalakrishnan R, Esmon CT, Pendurthi UR, Rao LV. Factor VIIa binding to endothelial cell protein C receptor protects vascular barrier integrity in vivo. J Thromb Haemost. 2014 May; 12(5):690-700. PMID: 24977291; PMCID: PMC4085578.
      5. Tolani B, Matta H, Gopalakrishnan R, Punj V, Chaudhary PM. NEMO is essential for Kaposi's sarcoma-associated herpesvirus-encoded vFLIP K13-induced gene expression and protection against death receptor-induced cell death, and its N-terminal 251 residues are sufficient for this process. J Virol. 2014 Jun; 88(11):6345-54. PMID: 24672029; PMCID: PMC4093867.
      6. Gopalakrishnan R, Matta H, Chaudhary PM. A purine scaffold HSP90 inhibitor BIIB021 has selective activity against KSHV-associated primary effusion lymphoma and blocks vFLIP K13-induced NF-?B. Clin Cancer Res. 2013 Sep 15; 19(18):5016-26. PMID: 23881928; PMCID: PMC3804723.
      7. Tolani B, Gopalakrishnan R, Punj V, Matta H, Chaudhary PM. Targeting Myc in KSHV-associated primary effusion lymphoma with BET bromodomain inhibitors. Oncogene. 2014 May 29; 33(22):2928-37. PMID: 23792448; PMCID: PMC4892892.
      8. Anandakumar P, Kamaraj S, Jagan S, Ramakrishnan G, Devaki T. Capsaicin provokes apoptosis and restricts benzo(a)pyrene induced lung tumorigenesis in Swiss albino mice. Int Immunopharmacol. 2013 Oct; 17(2):254-9. PMID: 23747734.
        View in: PubMed
      9. Gopalakrishnan R, Sundaram J, Sattu K, Pandi A, Thiruvengadam D. Dietary supplementation of silymarin is associated with decreased cell proliferation, increased apoptosis, and activation of detoxification system in hepatocellular carcinoma. Mol Cell Biochem. 2013 May; 377(1-2):163-76. PMID: 23397134.
        View in: PubMed
      10. Anandakumar P, Kamaraj S, Jagan S, Ramakrishnan G, Asokkumar S, Naveenkumar C, Raghunandhakumar S, Devaki T. Capsaicin inhibits benzo(a)pyrene-induced lung carcinogenesis in an in vivo mouse model. Inflamm Res. 2012 Nov; 61(11):1169-75. PMID: 22735861.
        View in: PubMed
      11. Matta H, Gopalakrishnan R, Graham C, Tolani B, Khanna A, Yi H, Suo Y, Chaudhary PM. Kaposi's sarcoma associated herpesvirus encoded viral FLICE inhibitory protein K13 activates NF-?B pathway independent of TRAF6, TAK1 and LUBAC. PLoS One. 2012; 7(5):e36601. PMID: 22590573; PMCID: PMC3348130.
      12. Gopalakrishnan R, Pendurthi UR, Hedner U, Agersø H, Esmon CT, Rao LV. Influence of endothelial cell protein C receptor on plasma clearance of factor VIIa. J Thromb Haemost. 2012 May; 10(5):971-3. PMID: 22372829; PMCID: PMC3883585.
      13. Sen P, Clark CA, Gopalakrishnan R, Hedner U, Esmon CT, Pendurthi UR, Rao LV. Factor VIIa binding to endothelial cell protein C receptor: differences between mouse and human systems. Thromb Haemost. 2012 May; 107(5):951-61. PMID: 22370814; PMCID: PMC3883592.
      14. Sen P, Nayak R, Clark CA, Gopalakrishnan R, Esmon CT, Pendurthi UR, Rao LV. Factor X binding to endothelial cell protein C receptor: comparison with factor VIIa and activated protein C. Blood. 2011 Sep 01; 118(9):2635-6. PMID: 21885613; PMCID: PMC3363977.
      15. Yang Y, Groshong JS, Matta H, Gopalakrishnan R, Yi H, Chaudhary PM. Constitutive NF-kappaB activation confers interleukin 6 (IL6) independence and resistance to dexamethasone and Janus kinase inhibitor INCB018424 in murine plasmacytoma cells. J Biol Chem. 2011 Aug 12; 286(32):27988-97. PMID: 21705340; PMCID: PMC3151044.
      16. Matta H, Gopalakrishnan R, Punj V, Yi H, Suo Y, Chaudhary PM. A20 is induced by Kaposi sarcoma-associated herpesvirus-encoded viral FLICE inhibitory protein (vFLIP) K13 and blocks K13-induced nuclear factor-kappaB in a negative feedback manner. J Biol Chem. 2011 Jun 17; 286(24):21555-64. PMID: 21531730; PMCID: PMC3122214.
      17. Kamaraj S, Anandakumar P, Jagan S, Ramakrishnan G, Devaki T. Hesperidin attenuates mitochondrial dysfunction during benzo(a)pyrene-induced lung carcinogenesis in mice. Fundam Clin Pharmacol. 2011 Feb; 25(1):91-8. PMID: 20199583.
        View in: PubMed
      18. Sen P, Gopalakrishnan R, Kothari H, Keshava S, Clark CA, Esmon CT, Pendurthi UR, Rao LV. Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection. Blood. 2011 Mar 17; 117(11):3199-208. PMID: 21252088; PMCID: PMC3062318.
      19. Gopalakrishnan R, Hedner U, Clark C, Pendurthi UR, Rao LV. rFVIIa transported from the blood stream into tissues is functionally active. J Thromb Haemost. 2010 Oct; 8(10):2318-21. PMID: 20695977; PMCID: PMC4472316.
      20. Kamaraj S, Anandakumar P, Jagan S, Ramakrishnan G, Devaki T. Modulatory effect of hesperidin on benzo(a)pyrene induced experimental lung carcinogenesis with reference to COX-2, MMP-2 and MMP-9. Eur J Pharmacol. 2010 Dec 15; 649(1-3):320-7. PMID: 20883688.
        View in: PubMed
      21. Gopalakrishnan R, Hedner U, Ghosh S, Nayak RC, Allen TC, Pendurthi UR, Rao LV. Bio-distribution of pharmacologically administered recombinant factor VIIa (rFVIIa). J Thromb Haemost. 2010 Feb; 8(2):301-10. PMID: 19943873; PMCID: PMC2849270.
      22. Nayak RC, Sen P, Ghosh S, Gopalakrishnan R, Esmon CT, Pendurthi UR, Rao LV. Endothelial cell protein C receptor cellular localization and trafficking: potential functional implications. Blood. 2009 Aug 27; 114(9):1974-86. PMID: 19587380; PMCID: PMC2738580.
      23. Anandakumar P, Kamaraj S, Jagan S, Ramakrishnan G, Naveenkumar C, Asokkumar S, Devaki T. Capsaicin alleviates the imbalance in xenobiotic metabolizing enzymes and tumor markers during experimental lung tumorigenesis. Mol Cell Biochem. 2009 Nov; 331(1-2):135-43. PMID: 19449198.
        View in: PubMed
      24. Anandakumar P, Kamaraj S, Ramakrishnan G, Jagan S, Devaki T. Chemopreventive task of capsaicin against benzo(a)pyrene-induced lung cancer in Swiss albino mice. Basic Clin Pharmacol Toxicol. 2009 May; 104(5):360-5. PMID: 19413655.
        View in: PubMed
      25. Ramakrishnan G, Lo Muzio L, Elinos-Báez CM, Jagan S, Augustine TA, Kamaraj S, Anandakumar P, Devaki T. Silymarin inhibited proliferation and induced apoptosis in hepatic cancer cells. Cell Prolif. 2009 Apr; 42(2):229-40. PMID: 19317806.
        View in: PubMed
      26. Anandakumar P, Jagan S, Kamaraj S, Ramakrishnan G, Clara JB, Pathitha D, Kavitha T, Devaki T. Ameliorating effect of capsaicin on alterations in lipid metabolism during mice lung carcinoma. Arch Pharm Res. 2009 Feb; 32(2):229-34. PMID: 19280153.
        View in: PubMed
      27. Anandakumar P, Kamaraj S, Jagan S, Ramakrishnan G, Devaki T. Lysosomal abnormalities during benzo(a)pyrene-induced experimental lung carcinogenesis--defensive role of capsaicin. Fundam Clin Pharmacol. 2009 Feb; 23(1):97-103. PMID: 19207542.
        View in: PubMed
      28. Anandakumar P, Kamaraj S, Jagan S, Ramakrishnan G, Devaki T. Effect of capsaicin on glucose metabolism studied in experimental lung carcinogenesis. Nat Prod Res. 2009; 23(8):763-74. PMID: 19418359.
        View in: PubMed
      29. Kamaraj S, Ramakrishnan G, Anandakumar P, Jagan S, Devaki T. Antioxidant and anticancer efficacy of hesperidin in benzo(a)pyrene induced lung carcinogenesis in mice. Invest New Drugs. 2009 Jun; 27(3):214-22. PMID: 18704264.
        View in: PubMed
      30. Ramakrishnan G, Jagan S, Kamaraj S, Anandakumar P, Devaki T. Silymarin attenuated mast cell recruitment thereby decreased the expressions of matrix metalloproteinases-2 and 9 in rat liver carcinogenesis. Invest New Drugs. 2009 Jun; 27(3):233-40. PMID: 18665326.
        View in: PubMed
      31. Jagan S, Ramakrishnan G, Anandakumar P, Kamaraj S, Devaki T. Antiproliferative potential of gallic acid against diethylnitrosamine-induced rat hepatocellular carcinoma. Mol Cell Biochem. 2008 Dec; 319(1-2):51-9. PMID: 18629614.
        View in: PubMed
      32. Anandakumar P, Jagan S, Kamaraj S, Ramakrishnan G, Titto AA, Devaki T. Beneficial influence of capsaicin on lipid peroxidation, membrane-bound enzymes and glycoprotein profile during experimental lung carcinogenesis. J Pharm Pharmacol. 2008 Jun; 60(6):803-8. PMID: 18498718.
        View in: PubMed
      33. Anandakumar P, Kamaraj S, Jagan S, Ramakrishnan G, Vinodhkumar R, Devaki T. Capsaicin modulates pulmonary antioxidant defense system during benzo(a)pyrene-induced lung cancer in Swiss albino mice. Phytother Res. 2008 Apr; 22(4):529-33. PMID: 18338764.
        View in: PubMed
      34. Ramakrishnan G, Elinos-Báez CM, Jagan S, Augustine TA, Kamaraj S, Anandakumar P, Devaki T. Silymarin downregulates COX-2 expression and attenuates hyperlipidemia during NDEA-induced rat hepatocellular carcinoma. Mol Cell Biochem. 2008 Jun; 313(1-2):53-61. PMID: 18373278.
        View in: PubMed
      35. Kamaraj S, Vinodhkumar R, Anandakumar P, Jagan S, Ramakrishnan G, Devaki T. The effects of quercetin on antioxidant status and tumor markers in the lung and serum of mice treated with benzo(a)pyrene. Biol Pharm Bull. 2007 Dec; 30(12):2268-73. PMID: 18057710.
        View in: PubMed
      36. Anandakumar P, Kamaraj S, Jagan S, Ramakrishnan G, Vinodhkumar R, Devaki T. Stabilization of pulmonary mitochondrial enzyme system by capsaicin during benzo(a)pyrene induced experimental lung cancer. Biomed Pharmacother. 2008 Jul-Aug; 62(6):390-4. PMID: 18023135.
        View in: PubMed
      37. Ramakrishnan G, Augustine TA, Jagan S, Vinodhkumar R, Devaki T. Effect of silymarin on N-nitrosodiethylamine induced hepatocarcinogenesis in rats. Exp Oncol. 2007 Mar; 29(1):39-44. PMID: 17431387.
        View in: PubMed
      38. Vinodhkumar R, Song YS, Ravikumar V, Ramakrishnan G, Devaki T. Depsipeptide a histone deacetlyase inhibitor down regulates levels of matrix metalloproteinases 2 and 9 mRNA and protein expressions in lung cancer cells (A549). Chem Biol Interact. 2007 Feb 20; 165(3):220-9. PMID: 17240363.
        View in: PubMed
      39. Ramakrishnan G, Raghavendran HR, Vinodhkumar R, Devaki T. Suppression of N-nitrosodiethylamine induced hepatocarcinogenesis by silymarin in rats. Chem Biol Interact. 2006 Jun 10; 161(2):104-14. PMID: 16643877.
        View in: PubMed
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