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Peter Danenberg, PhD

Title(s)Professor of Biochemistry & Molecular Medicine
AddressBMT B11G 1333 San Pablo Street
Health Sciences Campus
Los Angeles CA 90089
Phone+1 626 791 5234
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    Collapse Biography 
    Collapse Awards and Honors
    American Cancer Society1979  - 1984Faculty Research Award

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    Dr. Danenberg received a B.S. degree in chemistry from the Case Institute of Technology (now Case-Western Reserve University) and a Ph.D. from the University of California at Santa Barbara. He did postdoctoral work in the laboratory of Charles Heidelberger at the University of Wisconsin's McArdle Laboratory for Cancer Research. The initial phase of Dr. Danenberg's research career involved studies on the mechanisms of action of cancer drugs, with particular emphasis on the interaction of the fluorinated pyrimidines with the enzyme thymidylate synthase. This work ultimately gave rise to the still widely-used drug combination of 5-fluorourcil and folinic acid. His subsequent research was directed at identifying tumor biomarkers that would predict response to anti-cancer agents with the aim of promoting the concept of personalized medicine in cancer. Positive results from these studies, together with a procedure that Dr. Danenberg patented for isolating intact mRNA from paraffin-embedded tissues, formed the basis for the founding of the biotech-diagnostic company Response Genetics, Inc.

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    MOLECULAR PROGNOSTIC INDICATORS IN ESOPHAGEAL CANCER
    NIH/NCI R01CA071716Mar 1, 1998 - Jul 31, 2003
    Role: Principal Investigator
    RESPONSE DETERMINANTS IN ADVANCED BREAST CANCER
    NIH/NCI R01CA060859Jul 1, 1994 - Jun 30, 1997
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Multiparametric liquid biopsy analysis in metastatic prostate cancer. JCI Insight. 2019 03 07; 4(5). Hodara E, Morrison G, Cunha A, Zainfeld D, Xu T, Xu Y, Dempsey PW, Pagano PC, Bischoff F, Khurana A, Koo S, Ting M, Cotter PD, Moore MW, Gunn S, Usher J, Rabizadeh S, Danenberg P, Danenberg K, Carpten J, Dorff T, Quinn D, Goldkorn A. PMID: 30702443.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    2. Frequencies and expression levels of programmed death ligand 1 (PD-L1) in circulating tumor RNA (ctRNA) in various cancer types. Biochem Biophys Res Commun. 2018 06 07; 500(3):621-625. Ishiba T, Hoffmann AC, Usher J, Elshimali Y, Sturdevant T, Dang M, Jaimes Y, Tyagi R, Gonzales R, Grino M, Pinski JK, Barzi A, Raez LE, Eberhardt WE, Theegarten D, Lenz HJ, Uetake H, Danenberg PV, Danenberg K. PMID: 29679564.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    3. Folates as adjuvants to anticancer agents: Chemical rationale and mechanism of action. Crit Rev Oncol Hematol. 2016 Oct; 106:118-31. Danenberg PV, Gustavsson B, Johnston P, Lindberg P, Moser R, Odin E, Peters GJ, Petrelli N. PMID: 27637357.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    4. Efficiency of fluorodeoxyglucose positron emission tomography/computed tomography to predict prognosis in breast cancer patients received neoadjuvant chemotherapy. Springerplus. 2015; 4:817. Ishiba T, Nakagawa T, Sato T, Nagahara M, Oda G, Sugimoto H, Kasahara M, Hosoya T, Kubota K, Fujioka T, Danenberg P, Danenberg K, Uetake H. PMID: 26722637.
      View in: PubMed   Mentions:
    5. Standing the test of time: targeting thymidylate biosynthesis in cancer therapy. Nat Rev Clin Oncol. 2014 May; 11(5):282-98. Wilson PM, Danenberg PV, Johnston PG, Lenz HJ, Ladner RD. PMID: 24732946.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCells
    6. Regulation of MLH1 mRNA and protein expression by promoter methylation in primary colorectal cancer: a descriptive and prognostic cancer marker study. Cell Oncol (Dordr). 2013 Oct; 36(5):411-9. Jensen LH, Rasmussen AA, Byriel L, Kuramochi H, Crüger DG, Lindebjerg J, Danenberg PV, Jakobsen A, Danenberg K. PMID: 24027018.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    7. EGFR, FLT1 and heparanase as markers identifying patients at risk of short survival in cholangiocarcinoma. PLoS One. 2013; 8(5):e64186. Hoffmann AC, Goekkurt E, Danenberg PV, Lehmann S, Ehninger G, Aust DE, Stoehlmacher-Williams J. PMID: 23704979.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    8. Glutathione S-transferase PI (GST-PI) mRNA expression and DNA methylation is involved in the pathogenesis and prognosis of NSCLC. Lung Cancer. 2012 Oct; 78(1):87-91. Grimminger PP, Maus MK, Schneider PM, Metzger R, Hölscher AH, Sugita H, Danenberg PV, Alakus H, Brabender J. PMID: 22884253.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    9. Intratumoral expression profiling of genes involved in angiogenesis in colorectal cancer patients treated with chemotherapy plus the VEGFR inhibitor PTK787/ZK 222584 (vatalanib). Pharmacogenomics J. 2013 Oct; 13(5):410-6. Wilson PM, Yang D, Azuma M, Shi MM, Danenberg KD, Lebwohl D, Sherrod A, Ladner RD, Zhang W, Danenberg PV, Trarbach T, Folprecht G, Meinhardt G, Lenz HJ. PMID: 22664478.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCellsCTClinical Trials
    10. Response prediction in metastasised colorectal cancer using intratumoural thymidylate synthase: results of a randomised multicentre trial. Eur J Cancer. 2012 Jul; 48(10):1443-51. Kornmann M, Hebart H, Danenberg K, Goeb R, Staib L, Kron M, Henne-Bruns D, Danenberg P, Link KH. PMID: 22133572.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    11. TS and ERCC-1 mRNA expressions and clinical outcome in patients with metastatic colon cancer in CONFIRM-1 and -2 clinical trials. Pharmacogenomics J. 2012 Oct; 12(5):404-11. Grimminger PP, Shi M, Barrett C, Lebwohl D, Danenberg KD, Brabender J, Vigen CL, Danenberg PV, Winder T, Lenz HJ. PMID: 21788964.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    12. Gene expression of the mismatch repair gene MSH2 in primary colorectal cancer. Tumour Biol. 2011 Oct; 32(5):977-83. Jensen LH, Kuramochi H, Crüger DG, Lindebjerg J, Kolvraa S, Danenberg P, Danenberg K, Jakobsen A. PMID: 21732224.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    13. Biomarkers for cetuximab-based neoadjuvant radiochemotherapy in locally advanced rectal cancer. Clin Cancer Res. 2011 May 15; 17(10):3469-77. Grimminger PP, Danenberg P, Dellas K, Arnold D, Rödel C, Machiels JP, Haustermans K, Debucquoy A, Velenik V, Sempoux C, Bracko M, Hölscher AH, Semrau R, Yang D, Danenberg K, Lenz HJ, Vallböhmer D. PMID: 21558395.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    14. Association of epidermal growth factor receptor activating mutations with low ERCC1 gene expression in non-small cell lung cancer. J Thorac Oncol. 2010 Dec; 5(12):1933-8. Gandara DR, Grimminger P, Mack PC, Lara PN, Li T, Danenberg PV, Danenberg KD. PMID: 20975603.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    15. The relationship between proangiogenic gene expression levels in prostate cancer and their prognostic value for clinical outcomes. Prostate. 2010 Nov 01; 70(15):1692-700. Mori R, Dorff TB, Xiong S, Tarabolous CJ, Ye W, Groshen S, Danenberg KD, Danenberg PV, Pinski JK. PMID: 20564320.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    16. Update of prognostic and predictive biomarkers in oropharyngeal squamous cell carcinoma: a review. Eur Arch Otorhinolaryngol. 2011 Jan; 268(1):5-16. Grimminger CM, Danenberg PV. PMID: 20827554.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    17. Low thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase mRNA expression correlate with prolonged survival in resected non-small-cell lung cancer. Clin Lung Cancer. 2010 Sep 01; 11(5):328-34. Grimminger PP, Schneider PM, Metzger R, Vallböhmer D, Hölscher AH, Danenberg PV, Brabender J. PMID: 20837458.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    18. MDR1 and ERCC1 expression predict outcome of patients with locally advanced bladder cancer receiving adjuvant chemotherapy. Neoplasia. 2010 Aug; 12(8):628-36. Hoffmann AC, Wild P, Leicht C, Bertz S, Danenberg KD, Danenberg PV, Stöhr R, Stöckle M, Lehmann J, Schuler M, Hartmann A. PMID: 20689757.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCTClinical Trials
    19. Ornithine decarboxylase mRNA expression in curatively resected non-small-cell lung cancer. Clin Lung Cancer. 2010 Mar 01; 11(2):114-9. Grimminger PP, Schneider PM, Metzger R, Vallböhmer D, Danenberg KD, Danenberg PV, Hölscher AH, Brabender J. PMID: 20199977.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    20. The prognostic role of Bcl-2 mRNA expression in curatively resected non-small cell lung cancer (NSCLC). Lung Cancer. 2010 Oct; 70(1):82-7. Grimminger PP, Schneider PM, Metzger R, Vallböhmer D, Danenberg KD, Danenberg PV, Hölscher AH, Brabender J. PMID: 20064672.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    21. Prognostic Significance and Clinicopathological Associations of COX-2 SNP in Patients with Nonsmall Cell Lung Cancer. J Oncol. 2009; 2009:139590. Grimminger PP, Stöhlmacher J, Vallböhmer D, Schneider PM, Hölscher AH, Metzger R, Danenberg PV, Brabender J. PMID: 20016751.
      View in: PubMed   Mentions:
    22. Epidermal growth factor receptor (EGFR) mRNA levels and protein expression levels in primary colorectal cancer and corresponding liver metastases. Cancer Chemother Pharmacol. 2010 Apr; 65(5):825-31. Kuramochi H, Hayashi K, Nakajima G, Kamikozuru H, Yamamoto M, Danenberg KD, Danenberg PV. PMID: 19701635.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    23. A three-gene signature for outcome in soft tissue sarcoma. Clin Cancer Res. 2009 Aug 15; 15(16):5191-8. Hoffmann AC, Hoffman AC, Danenberg KD, Taubert H, Danenberg PV, Wuerl P. PMID: 19671876.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    24. Loss of heterozygosity at thymidylate synthase locus in Barrett's metaplasia, dysplasia, and carcinoma sequences. BMC Cancer. 2009 May 21; 9:157. Kuramochi H, Uchida K, Peters JH, Shimizu D, Vallbohmer D, Schneider S, Danenberg KD, Danenberg PV. PMID: 19460136.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    25. Messenger RNA expression of COX-2 and angiogenic factors in primary colorectal cancer and corresponding liver metastasis. Int J Oncol. 2009 Apr; 34(4):1147-53. Kobayashi H, Sugihara K, Uetake H, Higuchi T, Yasuno M, Enomoto M, Iida S, Lenz HJ, Danenberg KD, Danenberg PV. PMID: 19287974.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    26. Alterations of p16 and p14ARF genes and their 9p21 locus in oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Jan; 107(1):81-91. Ohta S, Uemura H, Matsui Y, Ishiguro H, Fujinami K, Kondo K, Miyamoto H, Yazawa T, Danenberg K, Danenberg PV, Tohnai I, Kubota Y. PMID: 19101490.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    27. Gene profiling and pathway analysis of neuroendocrine transdifferentiated prostate cancer cells. Prostate. 2009 Jan 01; 69(1):12-23. Mori R, Xiong S, Wang Q, Tarabolous C, Shimada H, Panteris E, Danenberg KD, Danenberg PV, Pinski JK. PMID: 18814146.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    28. Thymidylate synthase, dihydropyrimidine dehydrogenase, ERCC1, and thymidine phosphorylase gene expression in primary and metastatic gastrointestinal adenocarcinoma tissue in patients treated on a phase I trial of oxaliplatin and capecitabine. BMC Cancer. 2008 Dec 23; 8:386. Uchida K, Danenberg PV, Danenberg KD, Grem JL. PMID: 19105824.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCTClinical Trials
    29. Messenger RNA expression of TS and ERCC1 in colorectal cancer and matched liver metastasis. Int J Oncol. 2008 Dec; 33(6):1257-62. Kobayashi H, Sugihara K, Uetake H, Higuchi T, Yasuno M, Enomoto M, Iida S, Azuma M, Mori R, Omori A, Lenz HJ, Danenberg KD, Danenberg PV. PMID: 19020759.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    30. Thymidylate synthase, dihydropyrimidine dehydrogenase, orotate phosphoribosyltransferase mRNA and protein expression levels in solid tumors in large scale population analysis. Int J Mol Med. 2008 Dec; 22(6):709-16. Fukui Y, Oka T, Nagayama S, Danenberg PV, Danenberg KD, Fukushima M. PMID: 19020767.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    31. Both beta-actin and GAPDH are useful reference genes for normalization of quantitative RT-PCR in human FFPE tissue samples of prostate cancer. Prostate. 2008 Oct 01; 68(14):1555-60. Mori R, Wang Q, Danenberg KD, Pinski JK, Danenberg PV. PMID: 18651557.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    32. Validation of a rodent model of Barrett's esophagus using quantitative gene expression profiling. Surg Endosc. 2009 Jun; 23(6):1346-52. Oh DS, DeMeester SR, Dunst CM, Mori R, Lehman BJ, Kuramochi H, Danenberg K, Danenberg P, Hagen JA, Chandrasoma P, DeMeester TR. PMID: 18813976.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    33. High expression of heparanase is significantly associated with dedifferentiation and lymph node metastasis in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA and via HIF1a to HB-EGF and bFGF. J Gastrointest Surg. 2008 Oct; 12(10):1674-81; discussion 1681-2. Hoffmann AC, Mori R, Vallbohmer D, Brabender J, Drebber U, Baldus SE, Klein E, Azuma M, Metzger R, Hoffmann C, Hoelscher AH, Danenberg KD, Prenzel KL, Danenberg PV. PMID: 18704599.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    34. Efficacy of laser capture microdissection plus RT-PCR technique in analyzing gene expression levels in human gastric cancer and colon cancer. BMC Cancer. 2008 Jul 25; 8:210. Makino H, Uetake H, Danenberg K, Danenberg PV, Sugihara K. PMID: 18652704.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    35. Molecular profiling including epidermal growth factor receptor and p21 expression in high-risk breast cancer patients as indicators of outcome. Ann Oncol. 2008 Nov; 19(11):1853-9. Somlo G, Chu P, Frankel P, Ye W, Groshen S, Doroshow JH, Danenberg K, Danenberg P. PMID: 18641005.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    36. High expression of HIF1a is a predictor of clinical outcome in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA, VEGF, and bFGF. Neoplasia. 2008 Jul; 10(7):674-9. Hoffmann AC, Mori R, Vallbohmer D, Brabender J, Klein E, Drebber U, Baldus SE, Cooc J, Azuma M, Metzger R, Hoelscher AH, Danenberg KD, Prenzel KL, Danenberg PV. PMID: 18592007.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    37. Predictors of response and survival for neoadjuvant treated patients with esophageal adenocarcinoma. Dis Esophagus. 2008; 21(7):601-6. Theisen J, Danenberg K, Ott K, Becker K, Danenberg P, Stein HJ, Siewert JR. PMID: 18430179.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    38. Plasma DNA is more reliable than carcinoembryonic antigen for diagnosis of recurrent esophageal cancer. J Am Coll Surg. 2008 Jul; 207(1):30-5. Banki F, Yacoub WN, Hagen JA, Mason RJ, Ayazi S, DeMeester SR, Lipham JC, Danenberg K, Danenberg P, DeMeester TR. PMID: 18589358.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    39. High intratumoral dihydropyrimidine dehydrogenase mRNA levels in pancreatic cancer associated with a high rate of response to S-1. Cancer Chemother Pharmacol. 2008 Dec; 63(1):85-9. Kuramochi H, Hayashi K, Uchida K, Nakajima G, Hatori T, Danenberg KD, Danenberg PV, Yamamoto M. PMID: 18309485.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    40. Messenger RNA expression of vascular endothelial growth factor and its receptors in primary colorectal cancer and corresponding liver metastasis. Ann Surg Oncol. 2008 Apr; 15(4):1232-8. Kobayashi H, Sugihara K, Uetake H, Higuchi T, Yasuno M, Enomoto M, Kuramochi H, Lenz HJ, Danenberg KD, Danenberg PV. PMID: 18239970.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    41. Plasma DNA: a molecular marker of surgical insult and postoperative recovery in esophageal cancer. Eur Surg Res. 2008; 40(3):273-8. Banki F, Mason RJ, Hagen JA, Demeester SR, Lipham JC, Danenberg K, Danenberg P, Demeester TR. PMID: 18219202.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    42. Adenocarcinoma developing in de novo Barrett's mucosa in the remnant esophagus after esophagectomy: clinical and molecular assessment. Dis Esophagus. 2008; 21(3):E6-8. Gutschow CA, Vallböhmer D, Stolte M, Oh D, Danenberg K, Danenberg P, Schneider PM, Hölscher AH. PMID: 18430096.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    43. Thymidylate synthase polymorphisms and mRNA expression are independent chemotherapy predictive markers in esophageal adenocarcinoma patients. Int J Oncol. 2008 Jan; 32(1):201-8. Kuramochi H, Tanaka K, Oh D, Lehman BJ, Dunst CM, Yang DY, De Meester SR, Hagen JA, Danenberg KD, De Meester TR, Danenberg PV. PMID: 18097560.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    44. Prognostic value of the androgen receptor and its coactivators in patients with D1 prostate cancer. Anticancer Res. 2008 Jan-Feb; 28(1B):425-30. Mori R, Wang Q, Quek ML, Tarabolous C, Cheung E, Ye W, Groshen S, Hawes D, Togo S, Shimada H, Danenberg KD, Danenberg PV, Pinski JK. PMID: 18383880.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    45. Serum lactate dehydrogenase levels and glycolysis significantly correlate with tumor VEGFA and VEGFR expression in metastatic CRC patients. Pharmacogenomics. 2007 Dec; 8(12):1705-13. Azuma M, Shi M, Danenberg KD, Gardner H, Barrett C, Jacques CJ, Sherod A, Iqbal S, El-Khoueiry A, Yang D, Zhang W, Danenberg PV, Lenz HJ. PMID: 18086000.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    46. Towards the molecular characterization of disease: comparison of molecular and histological analysis of esophageal epithelia. J Gastrointest Surg. 2007 Sep; 11(9):1095-104. Vallböhmer D, Marjoram P, Kuramochi H, Shimizu D, Jung H, DeMeester SR, Oh D, Chandrasoma PT, Danenberg KD, DeMeester TR, Danenberg PV, Peters JH. PMID: 17623264.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    47. DPD is a molecular determinant of capecitabine efficacy in colorectal cancer. Int J Oncol. 2007 Aug; 31(2):413-8. Vallböhmer D, Yang DY, Kuramochi H, Shimizu D, Danenberg KD, Lindebjerg J, Nielsen JN, Jakobsen A, Danenberg PV. PMID: 17611699.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    48. Plasma DNA as a molecular marker for completeness of resection and recurrent disease in patients with esophageal cancer. Arch Surg. 2007 Jun; 142(6):533-8; discussion 538-9. Banki F, Mason RJ, Oh D, Hagen JA, DeMeester SR, Lipham JC, Tanaka K, Danenberg KD, Yacoub WN, Danenberg PV, DeMeester TR. PMID: 17576889.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    49. Reduction of interleukin 8 gene expression in reflux esophagitis and Barrett's esophagus with antireflux surgery. Arch Surg. 2007 Jun; 142(6):554-9; discussion 559-60. Oh DS, DeMeester SR, Vallbohmer D, Mori R, Kuramochi H, Hagen JA, Lipham J, Danenberg KD, Danenberg PV, Chandrasoma P, DeMeester TR. PMID: 17576892.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    50. Human equilibrative nucleoside transporter 1 is associated with the chemosensitivity of gemcitabine in human pancreatic adenocarcinoma and biliary tract carcinoma cells. Oncol Rep. 2007 May; 17(5):1201-5. Mori R, Ishikawa T, Ichikawa Y, Taniguchi K, Matsuyama R, Ueda M, Fujii Y, Endo I, Togo S, Danenberg PV, Shimada H. PMID: 17390066.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    51. Predictive value of MSH2 gene expression in colorectal cancer treated with capecitabine. Clin Colorectal Cancer. 2007 Mar; 6(6):433-5. Jensen LH, Danenberg KD, Danenberg PV, Jakobsen A. PMID: 17531106.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCellsCTClinical Trials
    52. Gene expression levels of epidermal growth factor receptor, survivin, and vascular endothelial growth factor as molecular markers of lymph node involvement in patients with locally advanced rectal cancer. Clin Colorectal Cancer. 2006 Nov; 6(4):305-11. Yang D, Schneider S, Azuma M, Iqbal S, El-Khoueiry A, Groshen S, Agafitei D, Danenberg KD, Danenberg PV, Ladner RD, Lenz HJ. PMID: 17241515.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    53. ERCC1 and RRM1 gene expressions but not EGFR are predictive of shorter survival in advanced non-small-cell lung cancer treated with cisplatin and gemcitabine. Ann Oncol. 2006 Dec; 17(12):1818-25. Ceppi P, Volante M, Novello S, Rapa I, Danenberg KD, Danenberg PV, Cambieri A, Selvaggi G, Saviozzi S, Calogero R, Papotti M, Scagliotti GV. PMID: 16980606.
      View in: PubMed   Mentions: 90     Fields:    Translation:Humans
    54. Epidermal growth factor receptor and epidermal growth factor receptor variant III gene expression in metastatic colorectal cancer. Clin Colorectal Cancer. 2006 Sep; 6(3):214-8. Azuma M, Danenberg KD, Iqbal S, El-Khoueiry A, Zhang W, Yang D, Koizumi W, Saigenji K, Danenberg PV, Lenz HJ. PMID: 17026791.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    55. Increasing cyclooxygenase-2 (cox-2) gene expression in the progression of Barrett's esophagus to adenocarcinoma correlates with that of Bcl-2. Int J Cancer. 2006 Aug 15; 119(4):765-70. Shimizu D, Vallböhmer D, Kuramochi H, Uchida K, Schneider S, Chandrasoma PT, Shimada H, DeMeester TR, Danenberg KD, Peters JH, DeMeester SR, Danenberg PV. PMID: 16550596.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    56. Genistein-induced neuroendocrine differentiation of prostate cancer cells. Prostate. 2006 Aug 01; 66(11):1136-43. Pinski J, Wang Q, Quek ML, Cole A, Cooc J, Danenberg K, Danenberg PV. PMID: 16652383.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    57. An in vivo platform for translational drug development in pancreatic cancer. Clin Cancer Res. 2006 Aug 01; 12(15):4652-61. Rubio-Viqueira B, Jimeno A, Cusatis G, Zhang X, Iacobuzio-Donahue C, Karikari C, Shi C, Danenberg K, Danenberg PV, Kuramochi H, Tanaka K, Singh S, Salimi-Moosavi H, Bouraoud N, Amador ML, Altiok S, Kulesza P, Yeo C, Messersmith W, Eshleman J, Hruban RH, Maitra A, Hidalgo M. PMID: 16899615.
      View in: PubMed   Mentions: 187     Fields:    Translation:HumansAnimals
    58. 5-fluorouracil-related gene expression levels in primary colorectal cancer and corresponding liver metastasis. Int J Cancer. 2006 Aug 01; 119(3):522-6. Kuramochi H, Hayashi K, Uchida K, Miyakura S, Shimizu D, Vallbohmer D, Park S, Danenberg KD, Takasaki K, Danenberg PV. PMID: 16572420.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    59. DNA methyltransferases messenger RNA expression and aberrant methylation of CpG islands in non-small-cell lung cancer: association and prognostic value. Clin Lung Cancer. 2006 Jul; 8(1):39-44. Vallböhmer D, Brabender J, Yang D, Schneider PM, Metzger R, Danenberg KD, Hölscher AH, Danenberg PV. PMID: 16870044.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    60. Antireflux surgery normalizes cyclooxygenase-2 expression in squamous epithelium of the distal esophagus. Am J Gastroenterol. 2006 Jul; 101(7):1458-66. Vallböhmer D, DeMeester SR, Oh DS, Banki F, Kuramochi H, Shimizu D, Hagen JA, Danenberg KD, Danenberg PV, Chandrasoma PT, Peters JH, DeMeester TR. PMID: 16863546.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    61. Epidermal growth factor receptor messenger RNA expression, gene dosage, and gefitinib sensitivity in non-small cell lung cancer. Clin Cancer Res. 2006 May 15; 12(10):3078-84. Dziadziuszko R, Witta SE, Cappuzzo F, Park S, Tanaka K, Danenberg PV, Barón AE, Crino L, Franklin WA, Bunn PA, Varella-Garcia M, Danenberg KD, Hirsch FR. PMID: 16707605.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    62. Molecular determinants in targeted therapy for esophageal adenocarcinoma. Arch Surg. 2006 May; 141(5):476-81; discussion 481-2. Vallböhmer D, Peters JH, Kuramochi H, Oh D, Yang D, Shimizu D, DeMeester SR, Hagen JA, Chandrasoma PT, Danenberg KD, Danenberg PV, DeMeester TR. PMID: 16702519.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    63. Sex differences in the predictive power of the molecular prognostic factor HER2/neu in patients with non-small-cell lung cancer. Clin Lung Cancer. 2006 Mar; 7(5):332-7. Vallböhmer D, Brabender J, Yang DY, Danenberg K, Schneider PM, Metzger R, Holscher AH, Danenberg PV. PMID: 16640805.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    64. Molecular factors of 5-fluorouracil metabolism in colorectal cancer: analysis of primary tumor and lymph node metastasis. Int J Oncol. 2006 Feb; 28(2):527-33. Vallböhmer D, Kuramochi H, Shimizu D, Danenberg KD, Lindebjerg J, Nielsen JN, Jakobsen A, Danenberg PV. PMID: 16391809.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    65. Cdx-2 expression in squamous and metaplastic columnar epithelia of the esophagus. Dis Esophagus. 2006; 19(4):260-6. Vallböhmer D, DeMeester SR, Peters JH, Oh DS, Kuramochi H, Shimizu D, Hagen JA, Danenberg KD, Danenberg PV, DeMeester TR, Chandrasoma PT. PMID: 16866857.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    66. Vascular endothelial growth factor messenger RNA expression level is preserved in liver metastases compared with corresponding primary colorectal cancer. Clin Cancer Res. 2006 Jan 01; 12(1):29-33. Kuramochi H, Hayashi K, Uchida K, Miyakura S, Shimizu D, Vallböhmer D, Park S, Danenberg KD, Takasaki K, Danenberg PV. PMID: 16397020.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    67. Expression and clinical significance of methylenetetrahydrofolate reductase in patients with colorectal cancer. Clin Colorectal Cancer. 2006 Jan; 5(5):344-9. Odin E, Wettergren Y, Carlsson G, Danenberg PV, Termini A, Willén R, Gustavsson B. PMID: 16512993.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    68. Molecular predictors of lymph node metastasis in colon cancer: increased risk with decreased thymidylate synthase expression. J Gastrointest Surg. 2005 Dec; 9(9):1216-21; discussion 1221. Artinyan A, Essani R, Lake J, Kaiser AM, Vukasin P, Danenberg P, Danenberg K, Haile R, Beart RW. PMID: 16332476.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    69. Increased CDX2 and decreased PITX1 homeobox gene expression in Barrett's esophagus and Barrett's-associated adenocarcinoma. Surgery. 2005 Nov; 138(5):924-31. Lord RV, Brabender J, Wickramasinghe K, DeMeester SR, Holscher A, Schneider PM, Danenberg PV, DeMeester TR. PMID: 16291394.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    70. Survivin, a potential biomarker in the development of Barrett's adenocarcinoma. Surgery. 2005 Oct; 138(4):701-6; discussion 706-7. Vallböhmer D, Peters JH, Oh D, Kuramochi H, Shimizu D, Demeester SR, Hagen JA, Chandrasoma PT, Danenberg KD, DeMeester TR, Danenberg P. PMID: 16269299.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    71. The molecular signature of normal squamous esophageal epithelium identifies the presence of a field effect and can discriminate between patients with Barrett's esophagus and patients with Barrett's-associated adenocarcinoma. Cancer Epidemiol Biomarkers Prev. 2005 Sep; 14(9):2113-7. Brabender J, Marjoram P, Lord RV, Metzger R, Salonga D, Vallböhmer D, Schäfer H, Danenberg KD, Danenberg PV, Selaru FM, Baldus SE, Hölscher AH, Meltzer SJ, Schneider PM. PMID: 16172218.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    72. Prediction of chemosensitivity of colorectal cancer to 5-fluorouracil by gene expression profiling with cDNA microarrays. Int J Oncol. 2005 Aug; 27(2):371-6. Shimizu D, Ishikawa T, Ichikawa Y, Togo S, Hayasizaki Y, Okazaki Y, Danenberg PV, Shimada H. PMID: 16010417.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    73. Thymidylate synthase and dihydropyrimidine dehydrogenase gene expression in breast cancer predicts 5-FU sensitivity by a histocultural drug sensitivity test. Cancer Lett. 2005 Jun 01; 223(1):103-11. Kakimoto M, Uetake H, Osanai T, Shirota Y, Takagi Y, Takeshita E, Toriya Y, Danenberg K, Danenberg PV, Sugihara K. PMID: 15890242.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    74. Intratumoral COX-2 gene expression is a predictive factor for colorectal cancer response to fluoropyrimidine-based chemotherapy. Clin Cancer Res. 2005 May 01; 11(9):3363-8. Uchida K, Schneider S, Yochim JM, Kuramochi H, Hayashi K, Takasaki K, Yang D, Danenberg KD, Danenberg PV. PMID: 15867236.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCTClinical Trials
    75. High gene expression of TS1, GSTP1, and ERCC1 are risk factors for survival in patients treated with trimodality therapy for esophageal cancer. Clin Cancer Res. 2005 Mar 15; 11(6):2215-21. Joshi MB, Shirota Y, Danenberg KD, Conlon DH, Salonga DS, Herndon JE, Danenberg PV, Harpole DH. PMID: 15788669.
      View in: PubMed   Mentions: 42     Fields:    Translation:Humans
    76. A molecular/epidemiologic analysis of expression of cyclooxygenases 1 and 2, use of nonsteroidal antiinflammatory drugs, and risk of colorectal adenoma. Clin Colorectal Cancer. 2005 Mar; 4(6):390-5. Haile RW, Yochim JM, Cortessis VK, Lin J, Levine AJ, Diep A, Danenberg K, Danenberg P. PMID: 15807932.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    77. Downregulation of TS, DPD, ERCC1, GST-Pi, EGFR, and HER2 gene expression after neoadjuvant three-modality treatment in patients with esophageal cancer. J Am Coll Surg. 2005 Mar; 200(3):336-44. Schneider S, Uchida K, Brabender J, Baldus SE, Yochim J, Danenberg KD, Salonga D, Chen P, Tsao-Wei D, Groshen S, Hoelscher AH, Schneider PM, Danenberg PV. PMID: 15737843.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    78. Expression of thymidylate synthase, dihydropyrimidine dehydrogenase, thymidine phosphorylase, and orotate phosphoribosyl transferase in prostate cancer. Prostate Cancer Prostatic Dis. 2005; 8(3):260-5. Miyoshi Y, Uemura H, Ishiguro H, Kitamura H, Nomura N, Danenberg PV, Kubota Y. PMID: 15999119.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    79. Comprehensive expression analysis of retinoic acid receptors and retinoid X receptors in non-small cell lung cancer: implications for tumor development and prognosis. Carcinogenesis. 2005 Mar; 26(3):525-30. Brabender J, Metzger R, Salonga D, Danenberg KD, Danenberg PV, Hölscher AH, Schneider PM. PMID: 15618235.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    80. Quantitative, tissue-specific analysis of cyclooxygenase gene expression in the pathogenesis of Barrett's adenocarcinoma. J Gastrointest Surg. 2004 Dec; 8(8):1007-16; discussion 1016-7. Kuramochi H, Vallböhmer D, Uchida K, Schneider S, Hamoui N, Shimizu D, Chandrasoma PT, DeMeester TR, Danenberg KD, Danenberg PV, Peters JH. PMID: 15585388.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    81. Pharmacogenomics of thymidylate synthase in cancer treatment. Front Biosci. 2004 Sep 01; 9:2484-94. Danenberg PV. PMID: 15353301.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    82. Increased acid exposure in patients with gastroesophageal reflux disease influences cyclooxygenase-2 gene expression in the squamous epithelium of the lower esophagus. Arch Surg. 2004 Jul; 139(7):712-6; discussion 716-7. Hamoui N, Peters JH, Schneider S, Uchida K, Yang D, Vallböhmer D, Valboehmer D, Hagen JA, DeMeester SR, DeMeester TR, Danenberg K, Danenberg P. PMID: 15249402.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    83. A multigene expression panel for the molecular diagnosis of Barrett's esophagus and Barrett's adenocarcinoma of the esophagus. Oncogene. 2004 Jun 10; 23(27):4780-8. Brabender J, Marjoram P, Salonga D, Metzger R, Schneider PM, Park JM, Schneider S, Hölscher AH, Yin J, Meltzer SJ, Danenberg KD, Danenberg PV, Lord RV. PMID: 15107828.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    84. High specificity of quantitative excision repair cross-complementing 1 messenger RNA expression for prediction of minor histopathological response to neoadjuvant radiochemotherapy in esophageal cancer. Clin Cancer Res. 2004 Jun 01; 10(11):3794-9. Warnecke-Eberz U, Metzger R, Miyazono F, Baldus SE, Neiss S, Brabender J, Schaefer H, Doerfler W, Bollschweiler E, Dienes HP, Mueller RP, Danenberg PV, Hoelscher AH, Schneider PM. PMID: 15173087.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    85. Role of retinoid X receptor mRNA expression in Barrett's esophagus. J Gastrointest Surg. 2004 May-Jun; 8(4):413-22. Brabender J, Lord RV, Metzger R, Park J, Salonga D, Danenberg KD, Hölscher AH, Danenberg PV, Schneider PM. PMID: 15120365.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    86. A longterm follow-up study of thymidylate synthase as a predictor for survival of patients with liver tumours receiving hepatic arterial infusion chemotherapy. Eur J Surg Oncol. 2004 May; 30(4):407-13. Hillenbrand A, Formentini A, Staib L, Sander S, Salonga D, Danenberg K, Danenberg P, Kornmann M. PMID: 15063894.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    87. Osteopontin but not osteonectin messenger RNA expression is a prognostic marker in curatively resected non-small cell lung cancer. Clin Cancer Res. 2004 Mar 01; 10(5):1588-96. Schneider S, Yochim J, Brabender J, Uchida K, Danenberg KD, Metzger R, Schneider PM, Salonga D, Hölscher AH, Danenberg PV. PMID: 15014008.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    88. HER-2 receptor expression, localization, and activation in colorectal cancer cell lines and human tumors. Int J Cancer. 2004 Feb 10; 108(4):540-8. Half E, Broaddus R, Danenberg KD, Danenberg PV, Ayers GD, Sinicrope FA. PMID: 14696118.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    89. Loss of heterozygosity at the thymidylate synthase (TS) locus on chromosome 18 affects tumor response and survival in individuals heterozygous for a 28-bp polymorphism in the TS gene. Clin Cancer Res. 2004 Jan 15; 10(2):433-9. Uchida K, Hayashi K, Kawakami K, Schneider S, Yochim JM, Kuramochi H, Takasaki K, Danenberg KD, Danenberg PV. PMID: 14760062.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    90. Quantitative determination of p16 gene expression by RT-PCR. Methods Mol Biol. 2004; 281:91-103. Schneider S, Uchida K, Salonga D, Yochim JM, Danenberg KD, Danenberg PV. PMID: 15220523.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    91. Differential SPARC mRNA expression in Barrett's oesophagus. Br J Cancer. 2003 Oct 20; 89(8):1508-12. Brabender J, Lord RV, Metzger R, Park J, Salonga D, Danenberg KD, Danenberg PV, Hölscher AH, Schneider PM. PMID: 14562024.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    92. Inhibition of pre-mRNA splicing by cisplatin and platinum analogs. Int J Oncol. 2003 Sep; 23(3):785-9. Schmittgen TD, Ju JF, Danenberg KD, Danenberg PV. PMID: 12888918.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    93. Association between Cyclooxygenase expression and colorectal adenoma characteristics. Cancer Res. 2003 Jul 15; 63(14):3891-3. Einspahr JG, Krouse RS, Yochim JM, Danenberg PV, Danenberg KD, Bhattacharyya AK, Martínez ME, Alberts DS. PMID: 12873979.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    94. Preoperative twice-weekly paclitaxel with concurrent radiation therapy followed by surgery and postoperative doxorubicin-based chemotherapy in locally advanced breast cancer: a phase I/II trial. J Clin Oncol. 2003 Mar 01; 21(5):864-70. Formenti SC, Volm M, Skinner KA, Spicer D, Cohen D, Perez E, Bettini AC, Groshen S, Gee C, Florentine B, Press M, Danenberg P, Muggia F. PMID: 12610186.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCTClinical Trials
    95. Thymidylate synthase expression in advanced colorectal cancer predicts for response to raltitrexed. Clin Cancer Res. 2003 Feb; 9(2):792-801. Farrugia DC, Ford HE, Cunningham D, Danenberg KD, Danenberg PV, Brabender J, McVicar AD, Aherne GW, Hardcastle A, McCarthy K, Jackman AL. PMID: 12576452.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCellsCTClinical Trials
    96. Vascular endothelial growth factor and basic fibroblast growth factor expression in esophageal adenocarcinoma and Barrett esophagus. J Thorac Cardiovasc Surg. 2003 Feb; 125(2):246-53. Lord RV, Park JM, Wickramasinghe K, DeMeester SR, Oberg S, Salonga D, Singer J, Peters JH, Danenberg KD, Demeester TR, Danenberg PV. PMID: 12579092.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    97. Quantitative O(6)-methylguanine DNA methyltransferase methylation analysis in curatively resected non-small cell lung cancer: associations with clinical outcome. Clin Cancer Res. 2003 Jan; 9(1):223-7. Brabender J, Usadel H, Metzger R, Schneider PM, Park J, Salonga D, Tsao-Wei DD, Groshen S, Lord RV, Takebe N, Schneider S, Hölscher AH, Danenberg KD, Danenberg PV. PMID: 12538473.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    98. Functional polymorphism of the thymidylate synthase gene in colorectal cancer accompanied by frequent loss of heterozygosity. Jpn J Cancer Res. 2002 Nov; 93(11):1221-9. Kawakami K, Ishida Y, Danenberg KD, Omura K, Watanabe G, Danenberg PV. PMID: 12460463.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    99. Low ERCC1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy in non-small cell lung cancer. Clin Cancer Res. 2002 Jul; 8(7):2286-91. Lord RV, Brabender J, Gandara D, Alberola V, Camps C, Domine M, Cardenal F, Sánchez JM, Gumerlock PH, Tarón M, Sánchez JJ, Danenberg KD, Danenberg PV, Rosell R. PMID: 12114432.
      View in: PubMed   Mentions: 153     Fields:    Translation:HumansCTClinical Trials
    100. Glutathione S-transferase-pi expression is downregulated in patients with Barrett's esophagus and esophageal adenocarcinoma. J Gastrointest Surg. 2002 May-Jun; 6(3):359-67. Brabender J, Lord RV, Wickramasinghe K, Metzger R, Schneider PM, Park JM, Hölscher AH, DeMeester TR, Danenberg KD, Danenberg PV. PMID: 12022988.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    101. Biochemical and molecular effects of UCN-01 in combination with 5-fluorodeoxyuridine in A431 human epidermoid cancer cells. Anticancer Drugs. 2002 Mar; 13(3):259-70. Grem JL, Danenberg KD, Kao V, Danenberg PV, Nguyen D. PMID: 11984070.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    102. Prognostic significance of cyclooxygenase 2 mRNA expression in non-small cell lung cancer. Ann Surg. 2002 Mar; 235(3):440-3. Brabender J, Park J, Metzger R, Schneider PM, Lord RV, Hölscher AH, Danenberg KD, Danenberg PV. PMID: 11882767.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    103. Low HER2/neu gene expression is associated with pathological response to concurrent paclitaxel and radiation therapy in locally advanced breast cancer. Int J Radiat Oncol Biol Phys. 2002 Feb 01; 52(2):397-405. Formenti SC, Spicer D, Skinner K, Cohen D, Groshen S, Bettini A, Naritoku W, Press M, Salonga D, Tsao-Wei D, Danenberg K, Danenberg P. PMID: 11872285.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    104. The role of retinoid X receptor messenger RNA expression in curatively resected non-small cell lung cancer. Clin Cancer Res. 2002 Feb; 8(2):438-43. Brabender J, Danenberg KD, Metzger R, Schneider PM, Lord RV, Groshen S, Tsao-Wei DD, Park J, Salonga D, Hölscher AH, Danenberg PV. PMID: 11839661.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    105. Quantitative adenomatous polyposis coli promoter methylation analysis in tumor tissue, serum, and plasma DNA of patients with lung cancer. Cancer Res. 2002 Jan 15; 62(2):371-5. Usadel H, Brabender J, Danenberg KD, Jerónimo C, Harden S, Engles J, Danenberg PV, Yang S, Sidransky D. PMID: 11809682.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansCells
    106. Relative gene expression in normal and tumor tissue by quantitative RT-PCR. Methods Mol Biol. 2002; 191:83-98. Salonga DS, Danenberg KD, Grem J, Park JM, Danenberg PV. PMID: 11951611.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    107. ERCC1 and thymidylate synthase mRNA levels predict survival for colorectal cancer patients receiving combination oxaliplatin and fluorouracil chemotherapy. J Clin Oncol. 2001 Dec 01; 19(23):4298-304. Shirota Y, Stoehlmacher J, Brabender J, Xiong YP, Uetake H, Danenberg KD, Groshen S, Tsao-Wei DD, Danenberg PV, Lenz HJ. PMID: 11731512.
      View in: PubMed   Mentions: 148     Fields:    Translation:Humans
    108. Different lengths of a polymorphic repeat sequence in the thymidylate synthase gene affect translational efficiency but not its gene expression. Clin Cancer Res. 2001 Dec; 7(12):4096-101. Kawakami K, Salonga D, Park JM, Danenberg KD, Uetake H, Brabender J, Omura K, Watanabe G, Danenberg PV. PMID: 11751507.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    109. Increased c-myb mRNA expression in Barrett's esophagus and Barrett's-associated adenocarcinoma. J Surg Res. 2001 Aug; 99(2):301-6. Brabender J, Lord RV, Danenberg KD, Metzger R, Schneider PM, Park JM, Salonga D, Groshen S, Tsao-Wei DD, DeMeester TR, Hölscher AH, Danenberg PV. PMID: 11469901.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    110. Reversal of cytosine arabinoside (ara-C) resistance by the synergistic combination of 6-thioguanine plus ara-C plus PEG-asparaginase (TGAP) in human leukemia lines lacking or expressing p53 protein. Cancer Chemother Pharmacol. 2001 Aug; 48(2):123-33. Fu CH, Martin-Aragon S, Weinberg KI, Ardi VC, Danenberg PV, Avramis VI. PMID: 11561778.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    111. Epidermal growth factor receptor and HER2-neu mRNA expression in non-small cell lung cancer Is correlated with survival. Clin Cancer Res. 2001 Jul; 7(7):1850-5. Brabender J, Danenberg KD, Metzger R, Schneider PM, Park J, Salonga D, Hölscher AH, Danenberg PV. PMID: 11448895.
      View in: PubMed   Mentions: 110     Fields:    Translation:Humans
    112. Adenomatous polyposis coli gene promoter hypermethylation in non-small cell lung cancer is associated with survival. Oncogene. 2001 Jun 14; 20(27):3528-32. Brabender J, Usadel H, Danenberg KD, Metzger R, Schneider PM, Lord RV, Wickramasinghe K, Lum CE, Park J, Salonga D, Singer J, Sidransky D, Hölscher AH, Meltzer SJ, Danenberg PV. PMID: 11429699.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    113. Expression of DT-diaphorase and cytochrome P450 reductase correlates with mitomycin C activity in human bladder tumors. Clin Cancer Res. 2001 May; 7(5):1313-9. Gan Y, Mo Y, Kalns JE, Lu J, Danenberg K, Danenberg P, Wientjes MG, Au JL. PMID: 11350900.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    114. Thymidine kinase, thymidylate synthase, and dihydropyrimidine dehydrogenase profiles of cell lines of the National Cancer Institute's Anticancer Drug Screen. Clin Cancer Res. 2001 Apr; 7(4):999-1009. Grem JL, Danenberg KD, Behan K, Parr A, Young L, Danenberg PV, Nguyen D, Drake J, Monks A, Allegra CJ. PMID: 11309351.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    115. Upregulation of ornithine decarboxylase mRNA expression in Barrett's esophagus and Barrett's-associated adenocarcinoma. J Gastrointest Surg. 2001 Mar-Apr; 5(2):174-81; discussion 182. Brabender J, Lord RV, Danenberg KD, Metzger R, Schneider PM, Uetake H, Kawakami K, Park JM, Salonga D, Peters JH, DeMeester TR, Hölscher AH, Danenberg PV. PMID: 11331481.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    116. Retinoic acid receptor-alpha messenger RNA expression is increased and retinoic acid receptor-gamma expression is decreased in Barrett's intestinal metaplasia, dysplasia, adenocarcinoma sequence. Surgery. 2001 Mar; 129(3):267-76. Lord RV, Tsai PI, Danenberg KD, Peters JH, Demeester TR, Tsao-Wei DD, Groshen S, Salonga D, Park JM, Crookes PF, Kiyabu M, Chandrasoma P, Danenberg PV. PMID: 11231454.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    117. Expression of metastases-associated genes in cervical cancers resected in the proliferative and secretory phases of the menstrual cycle. Clin Cancer Res. 2000 Dec; 6(12):4653-7. Formenti S, Felix J, Salonga D, Danenberg K, Pike MC, Danenberg P. PMID: 11156216.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    118. [Molecular markers as basis for chemotherapy?]. Chirurg. 2000 Dec; 71(12):1433-9. Brabender J, Lenz HJ, Danenberg PV. PMID: 11195061.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    119. Hypermethylated APC DNA in plasma and prognosis of patients with esophageal adenocarcinoma. J Natl Cancer Inst. 2000 Nov 15; 92(22):1805-11. Kawakami K, Brabender J, Lord RV, Groshen S, Greenwald BD, Krasna MJ, Yin J, Fleisher AS, Abraham JM, Beer DG, Sidransky D, Huss HT, Demeester TR, Eads C, Laird PW, Ilson DH, Kelsen DP, Harpole D, Moore MB, Danenberg KD, Danenberg PV, Meltzer SJ. PMID: 11078757.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansCells
    120. Fields of aberrant CpG island hypermethylation in Barrett's esophagus and associated adenocarcinoma. Cancer Res. 2000 Sep 15; 60(18):5021-6. Eads CA, Lord RV, Kurumboor SK, Wickramasinghe K, Skinner ML, Long TI, Peters JH, DeMeester TR, Danenberg KD, Danenberg PV, Laird PW, Skinner KA. PMID: 11016622.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansCells
    121. Thymidylate synthase quantitation and in vitro chemosensitivity testing predicts responses and survival of patients with isolated nonresectable liver tumors receiving hepatic arterial infusion chemotherapy. Cancer. 2000 Jul 15; 89(2):288-96. Link KH, Kornmann M, Butzer U, Leder G, Sunelaitis E, Pillasch J, Salonga D, Danenberg KD, Danenberg PV, Beger HG. PMID: 10918158.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCTClinical Trials
    122. Levels of E2F-1 expression are higher in lung metastasis of colon cancer as compared with hepatic metastasis and correlate with levels of thymidylate synthase. Cancer Res. 2000 May 01; 60(9):2365-7. Banerjee D, Gorlick R, Liefshitz A, Danenberg K, Danenberg PC, Danenberg PV, Klimstra D, Jhanwar S, Cordon-Cardo C, Fong Y, Kemeny N, Bertino JR. PMID: 10811110.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    123. MethyLight: a high-throughput assay to measure DNA methylation. Nucleic Acids Res. 2000 Apr 15; 28(8):E32. Eads CA, Danenberg KD, Kawakami K, Saltz LB, Blake C, Shibata D, Danenberg PV, Laird PW. PMID: 10734209.
      View in: PubMed   Mentions: 408     Fields:    Translation:HumansCells
    124. Theoretical considerations and in vitro concentration response studies with two human colorectal carcinoma cell lines. The rational experimental base for clinical studies in regional chemotherapy. Gan To Kagaku Ryoho. 2000 Apr; 27(4):565-77. Leder GH, Pillasch J, Kornmann M, Danenberg PV, Link KH. PMID: 10790999.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    125. Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase. Clin Cancer Res. 2000 Apr; 6(4):1322-7. Salonga D, Danenberg KD, Johnson M, Metzger R, Groshen S, Tsao-Wei DD, Lenz HJ, Leichman CG, Leichman L, Diasio RB, Danenberg PV. PMID: 10778957.
      View in: PubMed   Mentions: 173     Fields:    Translation:HumansCTClinical Trials
    126. Markedly decreased binding of vincristine to tubulin in vinca alkaloid-resistant Chinese hamster cells is associated with selective overexpression of alpha and beta tubulin isoforms. Biochem Biophys Res Commun. 2000 Mar 05; 269(1):21-4. Sirotnak FM, Danenberg KD, Chen J, Fritz F, Danenberg PV. PMID: 10694470.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    127. Telomerase reverse transcriptase expression is increased early in the Barrett's metaplasia, dysplasia, adenocarcinoma sequence. J Gastrointest Surg. 2000 Mar-Apr; 4(2):135-42. Lord RV, Salonga D, Danenberg KD, Peters JH, DeMeester TR, Park JM, Johansson J, Skinner KA, Chandrasoma P, DeMeester SR, Bremner CG, Tsai PI, Danenberg PV. PMID: 10675236.
      View in: PubMed   Mentions: 56     Fields:    Translation:Humans
    128. Modulation of RTX cytotoxicity by thymidine and dipyridamole in vitro: implications for chemotherapy. Cancer Chemother Pharmacol. 2000; 45(2):142-8. Lehman NL, Danenberg PV. PMID: 10663629.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    129. Thymidylate synthase inhibitors. Semin Oncol. 1999 Dec; 26(6):621-31. Danenberg PV, Malli H, Swenson S. PMID: 10606255.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    130. Rapid activation of MDR1 gene expression in human metastatic sarcoma after in vivo exposure to doxorubicin. Clin Cancer Res. 1999 Nov; 5(11):3352-6. Abolhoda A, Wilson AE, Ross H, Danenberg PV, Burt M, Scotto KW. PMID: 10589744.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    131. Cyclooxygenase-2 in Barrett's esophagus, Barrett's adenocarcinomas, and esophageal SCC: ready for clinical trials. Am J Gastroenterol. 1999 Aug; 94(8):2313-5. Lord RV, Danenberg KD, Danenberg PV. PMID: 10445576.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    132. Inhibition of cyclin D1 expression in human pancreatic cancer cells is associated with increased chemosensitivity and decreased expression of multiple chemoresistance genes. Cancer Res. 1999 Jul 15; 59(14):3505-11. Kornmann M, Danenberg KD, Arber N, Beger HG, Danenberg PV, Korc M. PMID: 10416617.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    133. CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression. Cancer Res. 1999 May 15; 59(10):2302-6. Eads CA, Danenberg KD, Kawakami K, Saltz LB, Danenberg PV, Laird PW. PMID: 10344733.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansCells
    134. Concurrent paclitaxel and radiation therapy for breast cancer. Semin Radiat Oncol. 1999 Apr; 9(2 Suppl 1):34-42. Formenti SC, Symmans WF, Volm M, Skinner K, Cohen D, Spicer D, Danenberg PV. PMID: 10210538.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCTClinical Trials
    135. High basal level gene expression of thymidine phosphorylase (platelet-derived endothelial cell growth factor) in colorectal tumors is associated with nonresponse to 5-fluorouracil. Clin Cancer Res. 1998 Oct; 4(10):2371-6. Metzger R, Danenberg K, Leichman CG, Salonga D, Schwartz EL, Wadler S, Lenz HJ, Groshen S, Leichman L, Danenberg PV. PMID: 9796967.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    136. Desensitization and sensitization of cells to fluoropyrimidines with different antisenses directed against thymidylate synthase messenger RNA. Clin Cancer Res. 1998 Sep; 4(9):2229-36. Ju J, Kane SE, Lenz HJ, Danenberg KD, Chu E, Danenberg PV. PMID: 9748143.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    137. Increased p21/WAF-1 and p53 protein levels following sequential three drug combination regimen of fludarabine, cytarabine and docetaxel induces apoptosis in human leukemia cells. Anticancer Res. 1998 Jul-Aug; 18(4A):2327-38. Avramis VI, Nandy P, Kwock R, Solorzano MM, Mukherjee SK, Danenberg P, Cohen LJ. PMID: 9703875.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    138. Restoration of wild-type p53 activity in p53-null HL-60 cells confers multidrug sensitivity. Clin Cancer Res. 1998 May; 4(5):1315-22. Ju JF, Banerjee D, Lenz HJ, Danenberg KD, Schmittgen TC, Spears CP, Schönthal AH, Manno DJ, Hochhauser D, Bertino JR, Danenberg PV. PMID: 9607592.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    139. p53 and thymidylate synthase expression in untreated stage II colon cancer: associations with recurrence, survival, and site. Clin Cancer Res. 1998 May; 4(5):1227-34. Lenz HJ, Danenberg KD, Leichman CG, Florentine B, Johnston PG, Groshen S, Zhou L, Xiong YP, Danenberg PV, Leichman LP. PMID: 9607581.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    140. p53 point mutations and thymidylate synthase messenger RNA levels in disseminated colorectal cancer: an analysis of response and survival. Clin Cancer Res. 1998 May; 4(5):1243-50. Lenz HJ, Hayashi K, Salonga D, Danenberg KD, Danenberg PV, Metzger R, Banerjee D, Bertino JR, Groshen S, Leichman LP, Leichman CG. PMID: 9607583.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    141. Higher levels of thymidylate synthase gene expression are observed in pulmonary as compared with hepatic metastases of colorectal adenocarcinoma. J Clin Oncol. 1998 Apr; 16(4):1465-9. Gorlick R, Metzger R, Danenberg KD, Salonga D, Miles JS, Longo GS, Fu J, Banerjee D, Klimstra D, Jhanwar S, Danenberg PV, Kemeny N, Bertino JR. PMID: 9552053.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    142. [Expression of p16 and p16 beta in squamous epithelial carcinomas and adenocarcinomas of the esophagus: differences in regulation dependent on kind of tumor and histology]. Langenbecks Arch Chir Suppl Kongressbd. 1998; 115(Suppl I):491-4. Metzger R, Danenberg K, Hayashi K, Hölscher AH, Danenberg PV. PMID: 14518304.
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    143. ERCC1 mRNA levels complement thymidylate synthase mRNA levels in predicting response and survival for gastric cancer patients receiving combination cisplatin and fluorouracil chemotherapy. J Clin Oncol. 1998 Jan; 16(1):309-16. Metzger R, Leichman CG, Danenberg KD, Danenberg PV, Lenz HJ, Hayashi K, Groshen S, Salonga D, Cohen H, Laine L, Crookes P, Silberman H, Baranda J, Konda B, Leichman L. PMID: 9440758.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansCTClinical Trials
    144. Original p53 status predicts for pathological response in locally advanced breast cancer patients treated preoperatively with continuous infusion 5-fluorouracil and radiation therapy. Int J Radiat Oncol Biol Phys. 1997 Dec 01; 39(5):1059-68. Formenti SC, Dunnington G, Uzieli B, Lenz H, Keren-Rosenberg S, Silberman H, Spicer D, Denk M, Leichman G, Groshen S, Watkins K, Muggia F, Florentine B, Press M, Danenberg K, Danenberg P. PMID: 9392545.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    145. Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin. J Clin Oncol. 1997 Oct; 15(10):3223-9. Leichman CG, Lenz HJ, Leichman L, Danenberg K, Baranda J, Groshen S, Boswell W, Metzger R, Tan M, Danenberg PV. PMID: 9336359.
      View in: PubMed   Mentions: 90     Fields:    Translation:Humans
    146. High frequency of simultaneous loss of p16 and p16beta gene expression in squamous cell carcinoma of the esophagus but not in adenocarcinoma of the esophagus or stomach. Oncogene. 1997 Sep 18; 15(12):1481-8. Hayashi K, Metzger R, Salonga D, Danenberg K, Leichman LP, Fink U, Sendler A, Kelsen D, Schwartz GK, Groshen S, Lenz HJ, Danenberg PV. PMID: 9333024.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    147. Thymidylate synthase is a predictor for response and resistance in hepatic artery infusion chemotherapy. Cancer Lett. 1997 Sep 16; 118(1):29-35. Kornmann M, Link KH, Lenz HJ, Pillasch J, Metzger R, Butzer U, Leder GH, Weindel M, Safi F, Danenberg KD, Beger HG, Danenberg PV. PMID: 9310257.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCellsCTClinical Trials
    148. Increased photosensitivity in HL60 cells expressing wild-type p53. Photochem Photobiol. 1997 Aug; 66(2):265-70. Fisher AM, Danenberg K, Banerjee D, Bertino JR, Danenberg P, Gomer CJ. PMID: 9277147.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    149. Thymidylate synthase mRNA level in adenocarcinoma of the stomach: a predictor for primary tumor response and overall survival. J Clin Oncol. 1996 Jan; 14(1):176-82. Lenz HJ, Leichman CG, Danenberg KD, Danenberg PV, Groshen S, Cohen H, Laine L, Crookes P, Silberman H, Baranda J, Garcia Y, Li J, Leichman L. PMID: 8558194.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansCellsCTClinical Trials
    150. Identification of mutations by RNA conformational polymorphism "bar code" analysis. Genomics. 1995 Nov 01; 30(1):120-2. Lenz HJ, Danenberg KD, Schnieders B, Banerjee D, Bertino JR, Leichman L, Danenberg PV. PMID: 8595893.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    151. Transfection of wild-type but not mutant p53 induces early monocytic differentiation in HL60 cells and increases their sensitivity to stress. Cell Growth Differ. 1995 Nov; 6(11):1405-13. Banerjee D, Lenz HJ, Schnieders B, Manno DJ, Ju JF, Spears CP, Hochhauser D, Danenberg K, Danenberg P, Bertino JR. PMID: 8562479.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    152. Rapid quantitative PCR for determination of relative gene expressions in tissue specimens. PCR Methods Appl. 1995 Apr; 4(5):305-8. Lenz HJ, Hill C, Danenberg KD, Leichman LL, Priest DG, Danenberg PV. PMID: 7580920.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    153. Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors. Cancer Res. 1995 Apr 01; 55(7):1407-12. Johnston PG, Lenz HJ, Leichman CG, Danenberg KD, Allegra CJ, Danenberg PV, Leichman L. PMID: 7882343.
      View in: PubMed   Mentions: 158     Fields:    Translation:HumansCells
    154. Gene amplification and multidrug resistance induced by the phosphatase-inhibitory tumor promoter, okadaic acid. Carcinogenesis. 1995 Mar; 16(3):637-41. Wang SJ, Scavetta R, Lenz HJ, Danenberg K, Danenberg PV, Schönthal AH. PMID: 7697825.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    155. Incorporation of 5-fluorouracil into U2 and U6 snRNA inhibits mRNA precursor splicing. J Biol Chem. 1994 Dec 16; 269(50):31962-8. Lenz HJ, Manno DJ, Danenberg KD, Danenberg PV. PMID: 7989372.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    156. Quantitative determination of the ratio of mutated to normal ras genes in the blood of leukemia patients by allele-specific PCR. Leuk Res. 1994 Sep; 18(9):693-702. Horikoshi T, Lenz HJ, Danenberg K, Koch OM, Bertino JR, Danenberg PV. PMID: 7934145.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    157. Effect of 5-fluoro- and 5-bromouracil substitution on the translation of human thymidylate synthase mRNA. J Biol Chem. 1994 Jun 10; 269(23):16269-75. Schmittgen TD, Danenberg KD, Horikoshi T, Lenz HJ, Danenberg PV. PMID: 8206932.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    158. Molecular detection and characterization of clonal cell populations in acute lymphocytic leukemia by analysis of conformational polymorphisms of cRNA molecules of rearranged T-cell-receptor-gamma and immunoglobulin heavy-chain genes. Leukemia. 1994 Jun; 8(6):946-52. Koch OM, Volkenandt M, Göker E, Buer J, Probst M, Banerjee D, Danenberg PV, Bertino JR. PMID: 8207989.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    159. Detection of clonal T-cell populations in gastrointestinal lymphomas by analysis of cRNA conformational polymorphisms of rearranged T-cell-receptor-gamma genes. Br J Haematol. 1994 Feb; 86(2):316-21. Koch OM, Probst M, Tiemann M, Jakob I, Volkenandt M, Wienecke R, Buer J, Atzpodien J, Lenz HJ, Danenberg PV. PMID: 8199020.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    160. Quantitative analysis of folylpolyglutamate synthetase gene expression in tumor tissues by the polymerase chain reaction: marked variation of expression among leukemia patients. Oncol Res. 1994; 6(7):329-35. Lenz HJ, Danenberg K, Schnieders B, Goeker E, Peters GJ, Garrow T, Shane B, Bertino JR, Danenberg PV. PMID: 7865908.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    161. Differential S100 beta expression in choroidal and skin melanomas: quantitation by the polymerase chain reaction. Invest Ophthalmol Vis Sci. 1993 Nov; 34(12):3366-75. Kan-Mitchell J, Liggett PE, Taylor CR, Rao N, Granada ES, Danenberg KD, White WL, Van Eldik LJ, Horikoshi T, Danenberg PV. PMID: 8225871.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    162. Conformational polymorphisms of cRNA of T-cell-receptor genes as a clone-specific molecular marker for cutaneous lymphoma. J Invest Dermatol. 1993 Oct; 101(4):514-6. Volkenandt M, Wienecke R, Koch OM, Buer J, Probst M, Atzpodien J, Horikoshi T, Danenberg K, Danenberg P, Bertino JR. PMID: 8409516.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    163. Rapid and sensitive molecular subtyping of microorganisms in clinical specimens. Lancet. 1993 Mar 27; 341(8848):830-1. Wienecke R, Volkenandt M, Koch O, Neubert U, McNutt NS, Danenberg PV, Bertino JR. PMID: 7681136.
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    164. Analyses of p53 gene mutations in primary human bladder cancer. Oncol Res. 1993; 5(6-7):245-9. Miyamoto H, Kubota Y, Shuin T, Torigoe S, Hosaka M, Iwasaki Y, Danenberg K, Danenberg PV. PMID: 8123944.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    165. Quantitative measurement of relative gene expression in human tumors. Methods Mol Biol. 1993; 15:177-88. Horikoshi T, Danenberg K, Volkenandt M, Stadlbauer T, Danenberg PV. PMID: 21400275.
      View in: PubMed   Mentions: 4     Fields:    
    166. Quantitation of gene copy number and mRNA using the polymerase chain reaction. Proc Soc Exp Biol Med. 1992 May; 200(1):1-6. Volkenandt M, Dicker AP, Banerjee D, Fanin R, Schweitzer B, Horikoshi T, Danenberg K, Danenberg P, Bertino JR. PMID: 1570351.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    167. NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity. Cancer Res. 1992 Feb 15; 52(4):797-802. Traver RD, Horikoshi T, Danenberg KD, Stadlbauer TH, Danenberg PV, Ross D, Gibson NW. PMID: 1737339.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansCells
    168. Detection of point mutations in human DNA by analysis of RNA conformation polymorphism(s). Nucleic Acids Res. 1992 Feb 11; 20(3):573-9. Danenberg PV, Horikoshi T, Volkenandt M, Danenberg K, Lenz HJ, Shea LC, Dicker AP, Simoneau A, Jones PA, Bertino JR. PMID: 1371351.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    169. p53 gene mutation in primary human renal cell carcinoma. Oncol Res. 1992; 4(11-12):467-72. Torigoe S, Shuin T, Kubota Y, Horikoshi T, Danenberg K, Danenberg PV. PMID: 1299377.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    170. Inactivation of Tetrahymena rRNA self-splicing by cis-platin proceeds through dissociable complexes. Nucleic Acids Res. 1991 Jun 11; 19(11):3123-8. Danenberg PV, Shea LC, Danenberg KD, Horikoshi T. PMID: 1905401.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    171. Effect of 5-fluorouracil substitution on the self-splicing activity of Tetrahymena ribosomal RNA. Cancer Res. 1990 Mar 15; 50(6):1757-63. Danenberg PV, Shea LC, Danenberg K. PMID: 2407343.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    172. Deoxyuridylate effects on thymidylate synthase-5-fluorodeoxyuridylate-folate ternary complex formation. Biochem Pharmacol. 1989 Sep 15; 38(18):2985-93. Spears CP, Hayes AA, Shahinian AH, Danenberg PV, Frösing R, Gustavsson BG. PMID: 2783153.
      View in: PubMed   Mentions: 3     Fields:    
    173. Characterization of the mode of binding of substrates to the active site of Tetrahymena self-splicing RNA using 5-fluorouracil-substituted mini-exons. Biochemistry. 1989 Aug 08; 28(16):6779-85. Danenberg PV, Shea LC, Danenberg K. PMID: 2675974.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    174. Activity of thymidylate synthetase and its inhibition by 5-fluorouracil in highly enzyme-overproducing cells resistant to 10-propargyl-5,8-dideazafolate. Mol Pharmacol. 1989 Aug; 36(2):219-23. Danenberg KD, Danenberg PV. PMID: 2528057.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    175. Synthesis and interaction with uridine phosphorylase of 5'-deoxy-4',5-difluorouridine, a new prodrug of 5-fluorouracil. J Med Chem. 1988 Jun; 31(6):1094-8. Ajmera S, Bapat AR, Stephanian E, Danenberg PV. PMID: 2967375.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    176. Concentration and time dependence of the toxicity of fluorinated pyrimidines to HT 29 colorectal carcinoma cells. Cancer Chemother Pharmacol. 1988; 22(1):58-62. Link KH, Aigner KR, Peschau K, Warthona M, Schwemmle K, Danenberg PV. PMID: 2969305.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    177. Methotrexate analogues. 29. Effect of gamma-aminobutyric acid spacers between the pteroyl and glutamate moieties on enzyme binding and cell growth inhibition. J Med Chem. 1986 Oct; 29(10):1872-6. Rosowsky A, Forsch RA, Freisheim JH, Danenberg PV, Moran RG, Wick MM. PMID: 2428979.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    178. Kinetics and mechanism of interaction of 10-propargyl-5,8-dideazafolate with thymidylate synthase. J Med Chem. 1986 Apr; 29(4):478-82. Pogolotti AL, Danenberg PV, Santi DV. PMID: 3754285.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    179. Evidence from chemical degradation studies for a covalent bond from 5-fluoro-2'-deoxyuridylate to N-5 of tetrahydrofolate in the ternary complex of thymidylate synthetase-5-fluoro-2'-deoxyuridylate-5,10-methylenetetrahydrofolate. J Biol Chem. 1985 Sep 15; 260(20):10996-1000. Pellino AM, Danenberg PV. PMID: 3928628.
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    180. Assay and time course of 5-fluorouracil incorporation into RNA of L1210/0 ascites cells in vivo. Mol Pharmacol. 1985 Feb; 27(2):302-7. Spears CP, Shani J, Shahinian AH, Wolf W, Heidelberger C, Danenberg PV. PMID: 2578605.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    181. Deoxyribonucleoside-induced selective modulation of cytotoxicity and mutagenesis. Basic Life Sci. 1985; 31:313-34. Peterson AR, Danenberg PV, Ibric LL, Peterson H. PMID: 3158302.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    182. Spectroscopic studies of ternary complexes of thymidylate synthetase, deoxyribonucleotides, and folate analogs. J Biol Chem. 1984 Sep 25; 259(18):11346-52. Lockshin A, Mondal K, Danenberg PV. PMID: 6236224.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    183. Thymidylate synthetase inhibition in malignant tumors and normal liver of patients given intravenous 5-fluorouracil. Cancer Res. 1984 Sep; 44(9):4144-50. Spears CP, Gustavsson BG, Mitchell MS, Spicer D, Berne M, Bernstein L, Danenberg PV. PMID: 6744325.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    184. Evidence that intracellular synthesis of 5-fluorouridine-5'-phosphate from 5-fluorouracil and 5-fluorouridine is compartmentalized. Biochem Biophys Res Commun. 1984 Jul 18; 122(1):439-45. Shani J, Danenberg PV. PMID: 6743344.
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    185. Studies on the mechanism of fluoropyrimidine cytotoxicity in l1210 cells: correlation with inhibition of thymidylate synthetase but not with incorporation into RNA. Pharm Res. 1984 May; 1(3):110-5. Danenberg KD, Becker D, Mulkins MA, Danenberg PV. PMID: 24277246.
      View in: PubMed   Mentions: 1     Fields:    
    186. Synthesis and biological activity of 5-fluoro-2',3'-dideoxy-3'-fluorouridine and its 5'-phosphate. J Med Chem. 1984 Jan; 27(1):11-4. Ajmera S, Bapat AR, Danenberg K, Danenberg PV. PMID: 6228661.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    187. Human leukemic cells resistant to 5-fluoro-2'-deoxyuridine contain a thymidylate synthetase with lower affinity for nucleotides. J Biol Chem. 1983 Apr 10; 258(7):4130-6. Bapat AR, Zarow C, Danenberg PV. PMID: 6220000.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    188. Induction of mutations by 5-fluorodeoxyuridine: a mechanism of self-potentiated drug resistance? Biochem Biophys Res Commun. 1983 Jan 27; 110(2):573-7. Peterson AR, Peterson H, Danenberg PV. PMID: 6220701.
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    189. Fluorinated pyrimidines and their nucleosides. Adv Enzymol Relat Areas Mol Biol. 1983; 54:58-119. Heidelberger C, Danenberg PV, Moran RG. PMID: 6189380.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    190. Therapeutic response of leukemic mice treated with fluorinated pyrimidines and inhibitors of deoxyuridylate synthesis. Biochem Pharmacol. 1982 Sep 15; 31(18):2929-35. Moran RG, Danenberg PV, Heidelberger C. PMID: 6215922.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    191. Synthesis and biological activity of 5'-substituted 5-fluoropyrimidine nucleosides. J Med Chem. 1982 Aug; 25(8):999-1002. Ajmera S, Danenberg PV. PMID: 7120290.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    192. Thymidylate synthetase - substrate complex formation. Mol Cell Biochem. 1982 Mar 05; 43(1):49-57. Danenberg PV, Lockshin A. PMID: 7078549.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    193. Tight-binding complexes of thymidylate synthetase, folate analogs and deoxyribonucleotides. Adv Enzyme Regul. 1982; 20:99-110. Danenberg PV, Lockshin A. PMID: 6810659.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    194. Large-scale and small-scale methods for the preparation of 5,10-methylenetetrahydrofolate. Prep Biochem. 1982; 12(5):381-93. Zarow C, Pellino AM, Danenberg PV. PMID: 6820505.
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    195. Interaction of 5-ethynyl-2'-deoxyuridylate with thymidylate synthetase. J Med Chem. 1981 Dec; 24(12):1537-40. Danenberg PV, Bhatt RS, Kundu NG, Danenberg K, Heidelberger C. PMID: 6796692.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    196. The incorporation of 5-fluoro-2'-deoxyuridine into DNA of mammalian tumor cells. Biochem Biophys Res Commun. 1981 Sep 30; 102(2):654-8. Danenberg PV, Heidelberger C, Mulkins MA, Peterson AR. PMID: 6458299.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    197. Biochemical factors affecting the tightness of 5-fluorodeoxyuridylate binding to human thymidylate synthetase. Biochem Pharmacol. 1981 Feb 01; 30(3):247-57. Lockshin A, Danenberg PV. PMID: 6939434.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    198. Fluorinated pyrimidines as tight-binding inhibitors of thymidylate synthetase. Pharmacol Ther. 1981; 13(1):69-90. Danenberg PV, Lockshin A. PMID: 6455671.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    199. Synthesis and biological activity of 5-fluoro-2'-deoxyuridine 5'-phosphorodiamidates. J Med Chem. 1980 Nov; 23(11):1229-32. Phelps ME, Woodman PW, Danenberg PV. PMID: 6779007.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    200. Hydrodynamic behavior of human and bacterial thymidylate synthetases and thymidylate synthetase--5-fluoro-2'-deoxyuridylate--5,10-methylenetetrahydrofolate complexes. Evidence for large conformational changes during catalysis. Biochemistry. 1980 Sep 02; 19(18):4244-51. Lockshin A, Danenberg PV. PMID: 6932226.
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    201. The incorporation of trifluorothymidine into calf thymus DNA in a cell-free system does not lead to chain termination. Mol Pharmacol. 1980 Jul; 18(1):148-50. Sarrif AM, Tone H, Danenberg PV, Heidelberger C. PMID: 6774228.
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    202. Thymidylate synthetase and 2'-deoxyuridylate form a tight complex in the presence of pteroyltriglutamate. J Biol Chem. 1979 Dec 25; 254(24):12285-8. Lockshin A, Danenberg PV. PMID: 115883.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    203. Evidence for a sequential interaction of the subunits of thymidylate synthetase. J Biol Chem. 1979 Jun 10; 254(11):4345-8. Danenberg KD, Danenberg PV. PMID: 108277.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    204. Thymidylate synthetase purified to homogeneity from human leukemic cells. Proc Natl Acad Sci U S A. 1979 Feb; 76(2):750-4. Lockshin A, Moran RG, Danenberg PV. PMID: 34155.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    205. Effect of 5, 10-methylenetetrahydrofolate on the dissociation of 5-fluoro-2'-deoxyuridylate from thymidylate synthetase: evidence for an ordered mechanism. Biochemistry. 1978 Sep 19; 17(19):4018-24. Danenberg PV, Danenberg KD. PMID: 101234.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    206. The interaction of liver alcohol dehydrogenase with phenyl adenine dinucleotide, a novel analog of pyridine nucleotide coenzymes. J Biol Chem. 1978 Sep 10; 253(17):5886-7. Danenberg PV, Danenberg KD, Cleland WW. PMID: 210161.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    207. Thymidylate synthetase - a target enzyme in cancer chemotherapy. Biochim Biophys Acta. 1977 Dec 23; 473(2):73-92. Danenberg PV. PMID: 145246.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansAnimalsCells
    208. Inhibition of hexokinase by multisubstrate analogs. Biochim Biophys Acta. 1977 Feb 09; 480(2):351-6. Danenberg PV, Danenberg KD. PMID: 836847.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    209. Separate identities of ligandin and the h-protein, a major protein to which carcinogenic hydrocarbons are covalently bound. Biochem Biophys Res Commun. 1976 Jun 07; 70(3):869-77. Sarrif AM, Danenberg PV, Heidelberger C. PMID: 820342.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    210. Synthesis and biological studies of 3-(beta-D-ribofuranosyl)-2,3,-dihydro-6H-1,3-oxazine-2,6-dione, a new pyrimidine nucleoside analog related to uridine. J Med Chem. 1976 May; 19(5):643-7. Chwang TL, Wood WF, Parkhurst JR, Nesnow S, Danenberg PV, Heidelberger C. PMID: 178870.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    211. The effect of Raney nickel on the covalent thymidylate synthetase-5-fluoro-2'-deoxyuridylate-5,10-methylenetetrahydrofolate complex. Biochemistry. 1976 Mar 23; 15(6):1331-7. Danenberg PV, Heidelberger C. PMID: 1252451.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    212. Growth inhibition of cells in cultures and of vaccinia virus infected HeLa cells by derivatives of trifluorothymidine. Chemotherapy. 1976; 22(3-4):221-31. Parkhurst JR, Danenberg PV, Heidelberger C. PMID: 178485.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    213. Inhibition of phenylalanyl-tRNA synthetase by aromatic guanidines and amidines. J Med Chem. 1975 May; 18(5):528-30. Danenberg PV, Santi DV. PMID: 1097688.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    214. Structures of reversible and irreversible complexes of thymidylate synthetase and fluorinated pyrimidine nucleotides. Biochemistry. 1974 Feb 26; 13(5):926-33. Danenberg PV, Langenbach RJ, Heidelberger C. PMID: 4205029.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    215. Purification of thymidylate synthetase with 2'-deoxyuridylate-agarose. Methods Enzymol. 1974; 34:520-3. Danenberg PV, Heidelberger C. PMID: 4217422.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    216. Synthesis of 5-trifluoromethyl-2'-deoxyuridine 5'-phosphate and 5-trifluoromethyl-2'-deoxyuridine 5'-triphosphate. J Med Chem. 1973 Jun; 16(6):712-4. Danenberg PV, Heidelberger C. PMID: 4351734.
      View in: PubMed   Mentions:    Fields:    
    217. Purification of thymidylate synthetase from L. casei by affinity chromatography. Biochem Biophys Res Commun. 1972 Nov 15; 49(4):1029-33. Danenberg PV, Langenbach RJ, Heidelberger C. PMID: 4629809.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    218. Thymidylate synthetase: mechanism of inhibition by 5-fluoro-2'-deoxyuridylate. Biochem Biophys Res Commun. 1972 Sep 26; 48(6):1565-71. Langenbach RJ, Danenberg PV, Heidelberger C. PMID: 4263280.
      View in: PubMed   Mentions: 41     Fields:    Translation:Cells
    219. Phenylalanyl transfer ribonucleic acid synthetase from Escherichia coli. Reaction parameters and order of substrate addition. Biochemistry. 1971 Dec 07; 10(25):4804-12. Santi DV, Danenberg PV, Satterly P. PMID: 4334585.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    220. Phenylalanyl transfer ribonucleic acid synthetase from Escherichia coli. Analysis of the phenylalanine binding site. Biochemistry. 1971 Dec 07; 10(25):4813-20. Santi DV, Danenberg PV. PMID: 4334586.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    221. Phenylalanyl transfer ribonucleic acid synthetase from Escherichia coli. Analysis of the adenosine triphosphate binding site. Biochemistry. 1971 Dec 07; 10(25):4821-4. Santi DV, Danenberg PV, Montgomery KA. PMID: 4334587.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
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