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Peter Danenberg, PhD

Title(s)Professor of Biochemistry & Molecular Medicine
Phone+1 626 791 5234
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    Collapse Biography 
    Collapse Awards and Honors
    American Cancer Society1979  - 1984Faculty Research Award

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    Collapse Overview
    Dr. Danenberg received a B.S. degree in chemistry from the Case Institute of Technology (now Case-Western Reserve University) and a Ph.D. from the University of California at Santa Barbara. He did postdoctoral work in the laboratory of Charles Heidelberger at the University of Wisconsin's McArdle Laboratory for Cancer Research. The initial phase of Dr. Danenberg's research career involved studies on the mechanisms of action of cancer drugs, with particular emphasis on the interaction of the fluorinated pyrimidines with the enzyme thymidylate synthase. This work ultimately gave rise to the still widely-used drug combination of 5-fluorourcil and folinic acid. His subsequent research was directed at identifying tumor biomarkers that would predict response to anti-cancer agents with the aim of promoting the concept of personalized medicine in cancer. Positive results from these studies, together with a procedure that Dr. Danenberg patented for isolating intact mRNA from paraffin-embedded tissues, formed the basis for the founding of the biotech-diagnostic company Response Genetics, Inc.

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    MOLECULAR PROGNOSTIC INDICATORS IN ESOPHAGEAL CANCER
    NIH/NCI R01CA071716Mar 1, 1998 - Jul 31, 2003
    Role: Principal Investigator
    RESPONSE DETERMINANTS IN ADVANCED BREAST CANCER
    NIH/NCI R01CA060859Jul 1, 1994 - Jun 30, 1997
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Hodara E, Morrison G, Cunha A, Zainfeld D, Xu T, Xu Y, Dempsey PW, Pagano PC, Bischoff F, Khurana A, Koo S, Ting M, Cotter PD, Moore MW, Gunn S, Usher J, Rabizadeh S, Danenberg P, Danenberg K, Carpten J, Dorff T, Quinn D, Goldkorn A. Multiparametric liquid biopsy analysis in metastatic prostate cancer. JCI Insight. 2019 Mar 07; 4(5). PMID: 30702443.
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    2. Ishiba T, Hoffmann AC, Usher J, Elshimali Y, Sturdevant T, Dang M, Jaimes Y, Tyagi R, Gonzales R, Grino M, Pinski JK, Barzi A, Raez LE, Eberhardt WE, Theegarten D, Lenz HJ, Uetake H, Danenberg PV, Danenberg K. Frequencies and expression levels of programmed death ligand 1 (PD-L1) in circulating tumor RNA (ctRNA) in various cancer types. Biochem Biophys Res Commun. 2018 06 07; 500(3):621-625. PMID: 29679564.
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    3. Danenberg PV, Gustavsson B, Johnston P, Lindberg P, Moser R, Odin E, Peters GJ, Petrelli N. Folates as adjuvants to anticancer agents: Chemical rationale and mechanism of action. Crit Rev Oncol Hematol. 2016 Oct; 106:118-31. PMID: 27637357.
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    4. Ishiba T, Nakagawa T, Sato T, Nagahara M, Oda G, Sugimoto H, Kasahara M, Hosoya T, Kubota K, Fujioka T, Danenberg P, Danenberg K, Uetake H. Efficiency of fluorodeoxyglucose positron emission tomography/computed tomography to predict prognosis in breast cancer patients received neoadjuvant chemotherapy. Springerplus. 2015; 4:817. PMID: 26722637.
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    5. Wilson PM, Danenberg PV, Johnston PG, Lenz HJ, Ladner RD. Standing the test of time: targeting thymidylate biosynthesis in cancer therapy. Nat Rev Clin Oncol. 2014 May; 11(5):282-98. PMID: 24732946.
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    6. Jensen LH, Rasmussen AA, Byriel L, Kuramochi H, Crüger DG, Lindebjerg J, Danenberg PV, Jakobsen A, Danenberg K. Regulation of MLH1 mRNA and protein expression by promoter methylation in primary colorectal cancer: a descriptive and prognostic cancer marker study. Cell Oncol (Dordr). 2013 Oct; 36(5):411-9. PMID: 24027018.
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    7. Hoffmann AC, Goekkurt E, Danenberg PV, Lehmann S, Ehninger G, Aust DE, Stoehlmacher-Williams J. EGFR, FLT1 and heparanase as markers identifying patients at risk of short survival in cholangiocarcinoma. PLoS One. 2013; 8(5):e64186. PMID: 23704979.
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    8. Grimminger PP, Maus MK, Schneider PM, Metzger R, Hölscher AH, Sugita H, Danenberg PV, Alakus H, Brabender J. Glutathione S-transferase PI (GST-PI) mRNA expression and DNA methylation is involved in the pathogenesis and prognosis of NSCLC. Lung Cancer. 2012 Oct; 78(1):87-91. PMID: 22884253.
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    9. Wilson PM, Yang D, Azuma M, Shi MM, Danenberg KD, Lebwohl D, Sherrod A, Ladner RD, Zhang W, Danenberg PV, Trarbach T, Folprecht G, Meinhardt G, Lenz HJ. Intratumoral expression profiling of genes involved in angiogenesis in colorectal cancer patients treated with chemotherapy plus the VEGFR inhibitor PTK787/ZK 222584 (vatalanib). Pharmacogenomics J. 2013 Oct; 13(5):410-6. PMID: 22664478.
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    10. Kornmann M, Hebart H, Danenberg K, Goeb R, Staib L, Kron M, Henne-Bruns D, Danenberg P, Link KH. Response prediction in metastasised colorectal cancer using intratumoural thymidylate synthase: results of a randomised multicentre trial. Eur J Cancer. 2012 Jul; 48(10):1443-51. PMID: 22133572.
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    11. Grimminger PP, Shi M, Barrett C, Lebwohl D, Danenberg KD, Brabender J, Vigen CL, Danenberg PV, Winder T, Lenz HJ. TS and ERCC-1 mRNA expressions and clinical outcome in patients with metastatic colon cancer in CONFIRM-1 and -2 clinical trials. Pharmacogenomics J. 2012 Oct; 12(5):404-11. PMID: 21788964.
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    12. Jensen LH, Kuramochi H, Crüger DG, Lindebjerg J, Kolvraa S, Danenberg P, Danenberg K, Jakobsen A. Gene expression of the mismatch repair gene MSH2 in primary colorectal cancer. Tumour Biol. 2011 Oct; 32(5):977-83. PMID: 21732224.
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    13. Grimminger PP, Danenberg P, Dellas K, Arnold D, Rödel C, Machiels JP, Haustermans K, Debucquoy A, Velenik V, Sempoux C, Bracko M, Hölscher AH, Semrau R, Yang D, Danenberg K, Lenz HJ, Vallböhmer D. Biomarkers for cetuximab-based neoadjuvant radiochemotherapy in locally advanced rectal cancer. Clin Cancer Res. 2011 May 15; 17(10):3469-77. PMID: 21558395.
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    14. Gandara DR, Grimminger P, Mack PC, Lara PN, Li T, Danenberg PV, Danenberg KD. Association of epidermal growth factor receptor activating mutations with low ERCC1 gene expression in non-small cell lung cancer. J Thorac Oncol. 2010 Dec; 5(12):1933-8. PMID: 20975603.
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    15. Mori R, Dorff TB, Xiong S, Tarabolous CJ, Ye W, Groshen S, Danenberg KD, Danenberg PV, Pinski JK. The relationship between proangiogenic gene expression levels in prostate cancer and their prognostic value for clinical outcomes. Prostate. 2010 Nov 01; 70(15):1692-700. PMID: 20564320.
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    16. Grimminger CM, Danenberg PV. Update of prognostic and predictive biomarkers in oropharyngeal squamous cell carcinoma: a review. Eur Arch Otorhinolaryngol. 2011 Jan; 268(1):5-16. PMID: 20827554.
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    17. Grimminger PP, Schneider PM, Metzger R, Vallböhmer D, Hölscher AH, Danenberg PV, Brabender J. Low thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase mRNA expression correlate with prolonged survival in resected non-small-cell lung cancer. Clin Lung Cancer. 2010 Sep 01; 11(5):328-34. PMID: 20837458.
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    18. Hoffmann AC, Wild P, Leicht C, Bertz S, Danenberg KD, Danenberg PV, Stöhr R, Stöckle M, Lehmann J, Schuler M, Hartmann A. MDR1 and ERCC1 expression predict outcome of patients with locally advanced bladder cancer receiving adjuvant chemotherapy. Neoplasia. 2010 Aug; 12(8):628-36. PMID: 20689757.
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    19. Grimminger PP, Schneider PM, Metzger R, Vallböhmer D, Danenberg KD, Danenberg PV, Hölscher AH, Brabender J. Ornithine decarboxylase mRNA expression in curatively resected non-small-cell lung cancer. Clin Lung Cancer. 2010 Mar 01; 11(2):114-9. PMID: 20199977.
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    20. Grimminger PP, Schneider PM, Metzger R, Vallböhmer D, Danenberg KD, Danenberg PV, Hölscher AH, Brabender J. The prognostic role of Bcl-2 mRNA expression in curatively resected non-small cell lung cancer (NSCLC). Lung Cancer. 2010 Oct; 70(1):82-7. PMID: 20064672.
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    21. Grimminger PP, Stöhlmacher J, Vallböhmer D, Schneider PM, Hölscher AH, Metzger R, Danenberg PV, Brabender J. Prognostic Significance and Clinicopathological Associations of COX-2 SNP in Patients with Nonsmall Cell Lung Cancer. J Oncol. 2009; 2009:139590. PMID: 20016751.
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    22. Kuramochi H, Hayashi K, Nakajima G, Kamikozuru H, Yamamoto M, Danenberg KD, Danenberg PV. Epidermal growth factor receptor (EGFR) mRNA levels and protein expression levels in primary colorectal cancer and corresponding liver metastases. Cancer Chemother Pharmacol. 2010 Apr; 65(5):825-31. PMID: 19701635.
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    23. Hoffmann AC, Hoffman AC, Danenberg KD, Taubert H, Danenberg PV, Wuerl P. A three-gene signature for outcome in soft tissue sarcoma. Clin Cancer Res. 2009 Aug 15; 15(16):5191-8. PMID: 19671876.
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    24. Kuramochi H, Uchida K, Peters JH, Shimizu D, Vallbohmer D, Schneider S, Danenberg KD, Danenberg PV. Loss of heterozygosity at thymidylate synthase locus in Barrett's metaplasia, dysplasia, and carcinoma sequences. BMC Cancer. 2009 May 21; 9:157. PMID: 19460136.
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    25. Kobayashi H, Sugihara K, Uetake H, Higuchi T, Yasuno M, Enomoto M, Iida S, Lenz HJ, Danenberg KD, Danenberg PV. Messenger RNA expression of COX-2 and angiogenic factors in primary colorectal cancer and corresponding liver metastasis. Int J Oncol. 2009 Apr; 34(4):1147-53. PMID: 19287974.
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    26. Ohta S, Uemura H, Matsui Y, Ishiguro H, Fujinami K, Kondo K, Miyamoto H, Yazawa T, Danenberg K, Danenberg PV, Tohnai I, Kubota Y. Alterations of p16 and p14ARF genes and their 9p21 locus in oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Jan; 107(1):81-91. PMID: 19101490.
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    27. Mori R, Xiong S, Wang Q, Tarabolous C, Shimada H, Panteris E, Danenberg KD, Danenberg PV, Pinski JK. Gene profiling and pathway analysis of neuroendocrine transdifferentiated prostate cancer cells. Prostate. 2009 Jan 01; 69(1):12-23. PMID: 18814146.
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    28. Uchida K, Danenberg PV, Danenberg KD, Grem JL. Thymidylate synthase, dihydropyrimidine dehydrogenase, ERCC1, and thymidine phosphorylase gene expression in primary and metastatic gastrointestinal adenocarcinoma tissue in patients treated on a phase I trial of oxaliplatin and capecitabine. BMC Cancer. 2008 Dec 23; 8:386. PMID: 19105824.
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    29. Kobayashi H, Sugihara K, Uetake H, Higuchi T, Yasuno M, Enomoto M, Iida S, Azuma M, Mori R, Omori A, Lenz HJ, Danenberg KD, Danenberg PV. Messenger RNA expression of TS and ERCC1 in colorectal cancer and matched liver metastasis. Int J Oncol. 2008 Dec; 33(6):1257-62. PMID: 19020759.
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    30. Fukui Y, Oka T, Nagayama S, Danenberg PV, Danenberg KD, Fukushima M. Thymidylate synthase, dihydropyrimidine dehydrogenase, orotate phosphoribosyltransferase mRNA and protein expression levels in solid tumors in large scale population analysis. Int J Mol Med. 2008 Dec; 22(6):709-16. PMID: 19020767.
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    31. Mori R, Wang Q, Danenberg KD, Pinski JK, Danenberg PV. Both beta-actin and GAPDH are useful reference genes for normalization of quantitative RT-PCR in human FFPE tissue samples of prostate cancer. Prostate. 2008 Oct 01; 68(14):1555-60. PMID: 18651557.
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    32. Oh DS, DeMeester SR, Dunst CM, Mori R, Lehman BJ, Kuramochi H, Danenberg K, Danenberg P, Hagen JA, Chandrasoma P, DeMeester TR. Validation of a rodent model of Barrett's esophagus using quantitative gene expression profiling. Surg Endosc. 2009 Jun; 23(6):1346-52. PMID: 18813976.
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    33. Hoffmann AC, Mori R, Vallbohmer D, Brabender J, Drebber U, Baldus SE, Klein E, Azuma M, Metzger R, Hoffmann C, Hoelscher AH, Danenberg KD, Prenzel KL, Danenberg PV. High expression of heparanase is significantly associated with dedifferentiation and lymph node metastasis in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA and via HIF1a to HB-EGF and bFGF. J Gastrointest Surg. 2008 Oct; 12(10):1674-81; discussion 1681-2. PMID: 18704599.
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    34. Makino H, Uetake H, Danenberg K, Danenberg PV, Sugihara K. Efficacy of laser capture microdissection plus RT-PCR technique in analyzing gene expression levels in human gastric cancer and colon cancer. BMC Cancer. 2008 Jul 25; 8:210. PMID: 18652704.
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    35. Somlo G, Chu P, Frankel P, Ye W, Groshen S, Doroshow JH, Danenberg K, Danenberg P. Molecular profiling including epidermal growth factor receptor and p21 expression in high-risk breast cancer patients as indicators of outcome. Ann Oncol. 2008 Nov; 19(11):1853-9. PMID: 18641005.
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    36. Hoffmann AC, Mori R, Vallbohmer D, Brabender J, Klein E, Drebber U, Baldus SE, Cooc J, Azuma M, Metzger R, Hoelscher AH, Danenberg KD, Prenzel KL, Danenberg PV. High expression of HIF1a is a predictor of clinical outcome in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA, VEGF, and bFGF. Neoplasia. 2008 Jul; 10(7):674-9. PMID: 18592007.
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    37. Theisen J, Danenberg K, Ott K, Becker K, Danenberg P, Stein HJ, Siewert JR. Predictors of response and survival for neoadjuvant treated patients with esophageal adenocarcinoma. Dis Esophagus. 2008; 21(7):601-6. PMID: 18430179.
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    38. Banki F, Yacoub WN, Hagen JA, Mason RJ, Ayazi S, DeMeester SR, Lipham JC, Danenberg K, Danenberg P, DeMeester TR. Plasma DNA is more reliable than carcinoembryonic antigen for diagnosis of recurrent esophageal cancer. J Am Coll Surg. 2008 Jul; 207(1):30-5. PMID: 18589358.
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    39. Kuramochi H, Hayashi K, Uchida K, Nakajima G, Hatori T, Danenberg KD, Danenberg PV, Yamamoto M. High intratumoral dihydropyrimidine dehydrogenase mRNA levels in pancreatic cancer associated with a high rate of response to S-1. Cancer Chemother Pharmacol. 2008 Dec; 63(1):85-9. PMID: 18309485.
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    40. Kobayashi H, Sugihara K, Uetake H, Higuchi T, Yasuno M, Enomoto M, Kuramochi H, Lenz HJ, Danenberg KD, Danenberg PV. Messenger RNA expression of vascular endothelial growth factor and its receptors in primary colorectal cancer and corresponding liver metastasis. Ann Surg Oncol. 2008 Apr; 15(4):1232-8. PMID: 18239970.
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    41. Banki F, Mason RJ, Hagen JA, Demeester SR, Lipham JC, Danenberg K, Danenberg P, Demeester TR. Plasma DNA: a molecular marker of surgical insult and postoperative recovery in esophageal cancer. Eur Surg Res. 2008; 40(3):273-8. PMID: 18219202.
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    42. Gutschow CA, Vallböhmer D, Stolte M, Oh D, Danenberg K, Danenberg P, Schneider PM, Hölscher AH. Adenocarcinoma developing in de novo Barrett's mucosa in the remnant esophagus after esophagectomy: clinical and molecular assessment. Dis Esophagus. 2008; 21(3):E6-8. PMID: 18430096.
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    43. Mori R, Wang Q, Quek ML, Tarabolous C, Cheung E, Ye W, Groshen S, Hawes D, Togo S, Shimada H, Danenberg KD, Danenberg PV, Pinski JK. Prognostic value of the androgen receptor and its coactivators in patients with D1 prostate cancer. Anticancer Res. 2008 Jan-Feb; 28(1B):425-30. PMID: 18383880.
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    44. Kuramochi H, Tanaka K, Oh D, Lehman BJ, Dunst CM, Yang DY, De Meester SR, Hagen JA, Danenberg KD, De Meester TR, Danenberg PV. Thymidylate synthase polymorphisms and mRNA expression are independent chemotherapy predictive markers in esophageal adenocarcinoma patients. Int J Oncol. 2008 Jan; 32(1):201-8. PMID: 18097560.
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    45. Azuma M, Shi M, Danenberg KD, Gardner H, Barrett C, Jacques CJ, Sherod A, Iqbal S, El-Khoueiry A, Yang D, Zhang W, Danenberg PV, Lenz HJ. Serum lactate dehydrogenase levels and glycolysis significantly correlate with tumor VEGFA and VEGFR expression in metastatic CRC patients. Pharmacogenomics. 2007 Dec; 8(12):1705-13. PMID: 18086000.
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    46. Vallböhmer D, Marjoram P, Kuramochi H, Shimizu D, Jung H, DeMeester SR, Oh D, Chandrasoma PT, Danenberg KD, DeMeester TR, Danenberg PV, Peters JH. Towards the molecular characterization of disease: comparison of molecular and histological analysis of esophageal epithelia. J Gastrointest Surg. 2007 Sep; 11(9):1095-104. PMID: 17623264.
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    47. Vallböhmer D, Yang DY, Kuramochi H, Shimizu D, Danenberg KD, Lindebjerg J, Nielsen JN, Jakobsen A, Danenberg PV. DPD is a molecular determinant of capecitabine efficacy in colorectal cancer. Int J Oncol. 2007 Aug; 31(2):413-8. PMID: 17611699.
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    48. Banki F, Mason RJ, Oh D, Hagen JA, DeMeester SR, Lipham JC, Tanaka K, Danenberg KD, Yacoub WN, Danenberg PV, DeMeester TR. Plasma DNA as a molecular marker for completeness of resection and recurrent disease in patients with esophageal cancer. Arch Surg. 2007 Jun; 142(6):533-8; discussion 538-9. PMID: 17576889.
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    49. Oh DS, DeMeester SR, Vallbohmer D, Mori R, Kuramochi H, Hagen JA, Lipham J, Danenberg KD, Danenberg PV, Chandrasoma P, DeMeester TR. Reduction of interleukin 8 gene expression in reflux esophagitis and Barrett's esophagus with antireflux surgery. Arch Surg. 2007 Jun; 142(6):554-9; discussion 559-60. PMID: 17576892.
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    50. Mori R, Ishikawa T, Ichikawa Y, Taniguchi K, Matsuyama R, Ueda M, Fujii Y, Endo I, Togo S, Danenberg PV, Shimada H. Human equilibrative nucleoside transporter 1 is associated with the chemosensitivity of gemcitabine in human pancreatic adenocarcinoma and biliary tract carcinoma cells. Oncol Rep. 2007 May; 17(5):1201-5. PMID: 17390066.
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    51. Jensen LH, Danenberg KD, Danenberg PV, Jakobsen A. Predictive value of MSH2 gene expression in colorectal cancer treated with capecitabine. Clin Colorectal Cancer. 2007 Mar; 6(6):433-5. PMID: 17531106.
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    52. Yang D, Schneider S, Azuma M, Iqbal S, El-Khoueiry A, Groshen S, Agafitei D, Danenberg KD, Danenberg PV, Ladner RD, Lenz HJ. Gene expression levels of epidermal growth factor receptor, survivin, and vascular endothelial growth factor as molecular markers of lymph node involvement in patients with locally advanced rectal cancer. Clin Colorectal Cancer. 2006 Nov; 6(4):305-11. PMID: 17241515.
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    53. Ceppi P, Volante M, Novello S, Rapa I, Danenberg KD, Danenberg PV, Cambieri A, Selvaggi G, Saviozzi S, Calogero R, Papotti M, Scagliotti GV. ERCC1 and RRM1 gene expressions but not EGFR are predictive of shorter survival in advanced non-small-cell lung cancer treated with cisplatin and gemcitabine. Ann Oncol. 2006 Dec; 17(12):1818-25. PMID: 16980606.
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    54. Azuma M, Danenberg KD, Iqbal S, El-Khoueiry A, Zhang W, Yang D, Koizumi W, Saigenji K, Danenberg PV, Lenz HJ. Epidermal growth factor receptor and epidermal growth factor receptor variant III gene expression in metastatic colorectal cancer. Clin Colorectal Cancer. 2006 Sep; 6(3):214-8. PMID: 17026791.
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    55. Shimizu D, Vallböhmer D, Kuramochi H, Uchida K, Schneider S, Chandrasoma PT, Shimada H, DeMeester TR, Danenberg KD, Peters JH, DeMeester SR, Danenberg PV. Increasing cyclooxygenase-2 (cox-2) gene expression in the progression of Barrett's esophagus to adenocarcinoma correlates with that of Bcl-2. Int J Cancer. 2006 Aug 15; 119(4):765-70. PMID: 16550596.
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    56. Rubio-Viqueira B, Jimeno A, Cusatis G, Zhang X, Iacobuzio-Donahue C, Karikari C, Shi C, Danenberg K, Danenberg PV, Kuramochi H, Tanaka K, Singh S, Salimi-Moosavi H, Bouraoud N, Amador ML, Altiok S, Kulesza P, Yeo C, Messersmith W, Eshleman J, Hruban RH, Maitra A, Hidalgo M. An in vivo platform for translational drug development in pancreatic cancer. Clin Cancer Res. 2006 Aug 01; 12(15):4652-61. PMID: 16899615.
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    57. Pinski J, Wang Q, Quek ML, Cole A, Cooc J, Danenberg K, Danenberg PV. Genistein-induced neuroendocrine differentiation of prostate cancer cells. Prostate. 2006 Aug 01; 66(11):1136-43. PMID: 16652383.
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    58. Kuramochi H, Hayashi K, Uchida K, Miyakura S, Shimizu D, Vallbohmer D, Park S, Danenberg KD, Takasaki K, Danenberg PV. 5-fluorouracil-related gene expression levels in primary colorectal cancer and corresponding liver metastasis. Int J Cancer. 2006 Aug 01; 119(3):522-6. PMID: 16572420.
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    59. Vallböhmer D, DeMeester SR, Oh DS, Banki F, Kuramochi H, Shimizu D, Hagen JA, Danenberg KD, Danenberg PV, Chandrasoma PT, Peters JH, DeMeester TR. Antireflux surgery normalizes cyclooxygenase-2 expression in squamous epithelium of the distal esophagus. Am J Gastroenterol. 2006 Jul; 101(7):1458-66. PMID: 16863546.
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    60. Vallböhmer D, Brabender J, Yang D, Schneider PM, Metzger R, Danenberg KD, Hölscher AH, Danenberg PV. DNA methyltransferases messenger RNA expression and aberrant methylation of CpG islands in non-small-cell lung cancer: association and prognostic value. Clin Lung Cancer. 2006 Jul; 8(1):39-44. PMID: 16870044.
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    61. Dziadziuszko R, Witta SE, Cappuzzo F, Park S, Tanaka K, Danenberg PV, Barón AE, Crino L, Franklin WA, Bunn PA, Varella-Garcia M, Danenberg KD, Hirsch FR. Epidermal growth factor receptor messenger RNA expression, gene dosage, and gefitinib sensitivity in non-small cell lung cancer. Clin Cancer Res. 2006 May 15; 12(10):3078-84. PMID: 16707605.
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    62. Vallböhmer D, Peters JH, Kuramochi H, Oh D, Yang D, Shimizu D, DeMeester SR, Hagen JA, Chandrasoma PT, Danenberg KD, Danenberg PV, DeMeester TR. Molecular determinants in targeted therapy for esophageal adenocarcinoma. Arch Surg. 2006 May; 141(5):476-81; discussion 481-2. PMID: 16702519.
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    63. Vallböhmer D, Brabender J, Yang DY, Danenberg K, Schneider PM, Metzger R, Holscher AH, Danenberg PV. Sex differences in the predictive power of the molecular prognostic factor HER2/neu in patients with non-small-cell lung cancer. Clin Lung Cancer. 2006 Mar; 7(5):332-7. PMID: 16640805.
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    64. Vallböhmer D, Kuramochi H, Shimizu D, Danenberg KD, Lindebjerg J, Nielsen JN, Jakobsen A, Danenberg PV. Molecular factors of 5-fluorouracil metabolism in colorectal cancer: analysis of primary tumor and lymph node metastasis. Int J Oncol. 2006 Feb; 28(2):527-33. PMID: 16391809.
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    65. Vallböhmer D, DeMeester SR, Peters JH, Oh DS, Kuramochi H, Shimizu D, Hagen JA, Danenberg KD, Danenberg PV, DeMeester TR, Chandrasoma PT. Cdx-2 expression in squamous and metaplastic columnar epithelia of the esophagus. Dis Esophagus. 2006; 19(4):260-6. PMID: 16866857.
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    66. Odin E, Wettergren Y, Carlsson G, Danenberg PV, Termini A, Willén R, Gustavsson B. Expression and clinical significance of methylenetetrahydrofolate reductase in patients with colorectal cancer. Clin Colorectal Cancer. 2006 Jan; 5(5):344-9. PMID: 16512993.
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    67. Kuramochi H, Hayashi K, Uchida K, Miyakura S, Shimizu D, Vallböhmer D, Park S, Danenberg KD, Takasaki K, Danenberg PV. Vascular endothelial growth factor messenger RNA expression level is preserved in liver metastases compared with corresponding primary colorectal cancer. Clin Cancer Res. 2006 Jan 01; 12(1):29-33. PMID: 16397020.
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    68. Artinyan A, Essani R, Lake J, Kaiser AM, Vukasin P, Danenberg P, Danenberg K, Haile R, Beart RW. Molecular predictors of lymph node metastasis in colon cancer: increased risk with decreased thymidylate synthase expression. J Gastrointest Surg. 2005 Dec; 9(9):1216-21; discussion 1221. PMID: 16332476.
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    69. Lord RV, Brabender J, Wickramasinghe K, DeMeester SR, Holscher A, Schneider PM, Danenberg PV, DeMeester TR. Increased CDX2 and decreased PITX1 homeobox gene expression in Barrett's esophagus and Barrett's-associated adenocarcinoma. Surgery. 2005 Nov; 138(5):924-31. PMID: 16291394.
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    70. Vallböhmer D, Peters JH, Oh D, Kuramochi H, Shimizu D, Demeester SR, Hagen JA, Chandrasoma PT, Danenberg KD, DeMeester TR, Danenberg P. Survivin, a potential biomarker in the development of Barrett's adenocarcinoma. Surgery. 2005 Oct; 138(4):701-6; discussion 706-7. PMID: 16269299.
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    71. Brabender J, Marjoram P, Lord RV, Metzger R, Salonga D, Vallböhmer D, Schäfer H, Danenberg KD, Danenberg PV, Selaru FM, Baldus SE, Hölscher AH, Meltzer SJ, Schneider PM. The molecular signature of normal squamous esophageal epithelium identifies the presence of a field effect and can discriminate between patients with Barrett's esophagus and patients with Barrett's-associated adenocarcinoma. Cancer Epidemiol Biomarkers Prev. 2005 Sep; 14(9):2113-7. PMID: 16172218.
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    72. Shimizu D, Ishikawa T, Ichikawa Y, Togo S, Hayasizaki Y, Okazaki Y, Danenberg PV, Shimada H. Prediction of chemosensitivity of colorectal cancer to 5-fluorouracil by gene expression profiling with cDNA microarrays. Int J Oncol. 2005 Aug; 27(2):371-6. PMID: 16010417.
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    73. Kakimoto M, Uetake H, Osanai T, Shirota Y, Takagi Y, Takeshita E, Toriya Y, Danenberg K, Danenberg PV, Sugihara K. Thymidylate synthase and dihydropyrimidine dehydrogenase gene expression in breast cancer predicts 5-FU sensitivity by a histocultural drug sensitivity test. Cancer Lett. 2005 Jun 01; 223(1):103-11. PMID: 15890242.
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    74. Uchida K, Schneider S, Yochim JM, Kuramochi H, Hayashi K, Takasaki K, Yang D, Danenberg KD, Danenberg PV. Intratumoral COX-2 gene expression is a predictive factor for colorectal cancer response to fluoropyrimidine-based chemotherapy. Clin Cancer Res. 2005 May 01; 11(9):3363-8. PMID: 15867236.
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    75. Joshi MB, Shirota Y, Danenberg KD, Conlon DH, Salonga DS, Herndon JE, Danenberg PV, Harpole DH. High gene expression of TS1, GSTP1, and ERCC1 are risk factors for survival in patients treated with trimodality therapy for esophageal cancer. Clin Cancer Res. 2005 Mar 15; 11(6):2215-21. PMID: 15788669.
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    76. Haile RW, Yochim JM, Cortessis VK, Lin J, Levine AJ, Diep A, Danenberg K, Danenberg P. A molecular/epidemiologic analysis of expression of cyclooxygenases 1 and 2, use of nonsteroidal antiinflammatory drugs, and risk of colorectal adenoma. Clin Colorectal Cancer. 2005 Mar; 4(6):390-5. PMID: 15807932.
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    77. Schneider S, Uchida K, Brabender J, Baldus SE, Yochim J, Danenberg KD, Salonga D, Chen P, Tsao-Wei D, Groshen S, Hoelscher AH, Schneider PM, Danenberg PV. Downregulation of TS, DPD, ERCC1, GST-Pi, EGFR, and HER2 gene expression after neoadjuvant three-modality treatment in patients with esophageal cancer. J Am Coll Surg. 2005 Mar; 200(3):336-44. PMID: 15737843.
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    78. Miyoshi Y, Uemura H, Ishiguro H, Kitamura H, Nomura N, Danenberg PV, Kubota Y. Expression of thymidylate synthase, dihydropyrimidine dehydrogenase, thymidine phosphorylase, and orotate phosphoribosyl transferase in prostate cancer. Prostate Cancer Prostatic Dis. 2005; 8(3):260-5. PMID: 15999119.
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    79. Brabender J, Metzger R, Salonga D, Danenberg KD, Danenberg PV, Hölscher AH, Schneider PM. Comprehensive expression analysis of retinoic acid receptors and retinoid X receptors in non-small cell lung cancer: implications for tumor development and prognosis. Carcinogenesis. 2005 Mar; 26(3):525-30. PMID: 15618235.
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    80. Kuramochi H, Vallböhmer D, Uchida K, Schneider S, Hamoui N, Shimizu D, Chandrasoma PT, DeMeester TR, Danenberg KD, Danenberg PV, Peters JH. Quantitative, tissue-specific analysis of cyclooxygenase gene expression in the pathogenesis of Barrett's adenocarcinoma. J Gastrointest Surg. 2004 Dec; 8(8):1007-16; discussion 1016-7. PMID: 15585388.
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    81. Danenberg PV. Pharmacogenomics of thymidylate synthase in cancer treatment. Front Biosci. 2004 Sep 01; 9:2484-94. PMID: 15353301.
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    82. Hamoui N, Peters JH, Schneider S, Uchida K, Yang D, Vallböhmer D, Valboehmer D, Hagen JA, DeMeester SR, DeMeester TR, Danenberg K, Danenberg P. Increased acid exposure in patients with gastroesophageal reflux disease influences cyclooxygenase-2 gene expression in the squamous epithelium of the lower esophagus. Arch Surg. 2004 Jul; 139(7):712-6; discussion 716-7. PMID: 15249402.
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    83. Brabender J, Marjoram P, Salonga D, Metzger R, Schneider PM, Park JM, Schneider S, Hölscher AH, Yin J, Meltzer SJ, Danenberg KD, Danenberg PV, Lord RV. A multigene expression panel for the molecular diagnosis of Barrett's esophagus and Barrett's adenocarcinoma of the esophagus. Oncogene. 2004 Jun 10; 23(27):4780-8. PMID: 15107828.
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    84. Warnecke-Eberz U, Metzger R, Miyazono F, Baldus SE, Neiss S, Brabender J, Schaefer H, Doerfler W, Bollschweiler E, Dienes HP, Mueller RP, Danenberg PV, Hoelscher AH, Schneider PM. High specificity of quantitative excision repair cross-complementing 1 messenger RNA expression for prediction of minor histopathological response to neoadjuvant radiochemotherapy in esophageal cancer. Clin Cancer Res. 2004 Jun 01; 10(11):3794-9. PMID: 15173087.
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    85. Brabender J, Lord RV, Metzger R, Park J, Salonga D, Danenberg KD, Hölscher AH, Danenberg PV, Schneider PM. Role of retinoid X receptor mRNA expression in Barrett's esophagus. J Gastrointest Surg. 2004 May-Jun; 8(4):413-22. PMID: 15120365.
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    86. Hillenbrand A, Formentini A, Staib L, Sander S, Salonga D, Danenberg K, Danenberg P, Kornmann M. A longterm follow-up study of thymidylate synthase as a predictor for survival of patients with liver tumours receiving hepatic arterial infusion chemotherapy. Eur J Surg Oncol. 2004 May; 30(4):407-13. PMID: 15063894.
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    87. Schneider S, Yochim J, Brabender J, Uchida K, Danenberg KD, Metzger R, Schneider PM, Salonga D, Hölscher AH, Danenberg PV. Osteopontin but not osteonectin messenger RNA expression is a prognostic marker in curatively resected non-small cell lung cancer. Clin Cancer Res. 2004 Mar 01; 10(5):1588-96. PMID: 15014008.
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    88. Half E, Broaddus R, Danenberg KD, Danenberg PV, Ayers GD, Sinicrope FA. HER-2 receptor expression, localization, and activation in colorectal cancer cell lines and human tumors. Int J Cancer. 2004 Feb 10; 108(4):540-8. PMID: 14696118.
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    89. Uchida K, Hayashi K, Kawakami K, Schneider S, Yochim JM, Kuramochi H, Takasaki K, Danenberg KD, Danenberg PV. Loss of heterozygosity at the thymidylate synthase (TS) locus on chromosome 18 affects tumor response and survival in individuals heterozygous for a 28-bp polymorphism in the TS gene. Clin Cancer Res. 2004 Jan 15; 10(2):433-9. PMID: 14760062.
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    90. Schneider S, Uchida K, Salonga D, Yochim JM, Danenberg KD, Danenberg PV. Quantitative determination of p16 gene expression by RT-PCR. Methods Mol Biol. 2004; 281:91-103. PMID: 15220523.
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    91. Brabender J, Lord RV, Metzger R, Park J, Salonga D, Danenberg KD, Danenberg PV, Hölscher AH, Schneider PM. Differential SPARC mRNA expression in Barrett's oesophagus. Br J Cancer. 2003 Oct 20; 89(8):1508-12. PMID: 14562024.
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    92. Schmittgen TD, Ju JF, Danenberg KD, Danenberg PV. Inhibition of pre-mRNA splicing by cisplatin and platinum analogs. Int J Oncol. 2003 Sep; 23(3):785-9. PMID: 12888918.
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    93. Einspahr JG, Krouse RS, Yochim JM, Danenberg PV, Danenberg KD, Bhattacharyya AK, Martínez ME, Alberts DS. Association between Cyclooxygenase expression and colorectal adenoma characteristics. Cancer Res. 2003 Jul 15; 63(14):3891-3. PMID: 12873979.
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    94. Formenti SC, Volm M, Skinner KA, Spicer D, Cohen D, Perez E, Bettini AC, Groshen S, Gee C, Florentine B, Press M, Danenberg P, Muggia F. Preoperative twice-weekly paclitaxel with concurrent radiation therapy followed by surgery and postoperative doxorubicin-based chemotherapy in locally advanced breast cancer: a phase I/II trial. J Clin Oncol. 2003 Mar 01; 21(5):864-70. PMID: 12610186.
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    95. Farrugia DC, Ford HE, Cunningham D, Danenberg KD, Danenberg PV, Brabender J, McVicar AD, Aherne GW, Hardcastle A, McCarthy K, Jackman AL. Thymidylate synthase expression in advanced colorectal cancer predicts for response to raltitrexed. Clin Cancer Res. 2003 Feb; 9(2):792-801. PMID: 12576452.
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    96. Lord RV, Park JM, Wickramasinghe K, DeMeester SR, Oberg S, Salonga D, Singer J, Peters JH, Danenberg KD, Demeester TR, Danenberg PV. Vascular endothelial growth factor and basic fibroblast growth factor expression in esophageal adenocarcinoma and Barrett esophagus. J Thorac Cardiovasc Surg. 2003 Feb; 125(2):246-53. PMID: 12579092.
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    97. Brabender J, Usadel H, Metzger R, Schneider PM, Park J, Salonga D, Tsao-Wei DD, Groshen S, Lord RV, Takebe N, Schneider S, Hölscher AH, Danenberg KD, Danenberg PV. Quantitative O(6)-methylguanine DNA methyltransferase methylation analysis in curatively resected non-small cell lung cancer: associations with clinical outcome. Clin Cancer Res. 2003 Jan; 9(1):223-7. PMID: 12538473.
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    98. Kawakami K, Ishida Y, Danenberg KD, Omura K, Watanabe G, Danenberg PV. Functional polymorphism of the thymidylate synthase gene in colorectal cancer accompanied by frequent loss of heterozygosity. Jpn J Cancer Res. 2002 Nov; 93(11):1221-9. PMID: 12460463.
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    99. Lord RV, Brabender J, Gandara D, Alberola V, Camps C, Domine M, Cardenal F, Sánchez JM, Gumerlock PH, Tarón M, Sánchez JJ, Danenberg KD, Danenberg PV, Rosell R. Low ERCC1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy in non-small cell lung cancer. Clin Cancer Res. 2002 Jul; 8(7):2286-91. PMID: 12114432.
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    100. Brabender J, Lord RV, Wickramasinghe K, Metzger R, Schneider PM, Park JM, Hölscher AH, DeMeester TR, Danenberg KD, Danenberg PV. Glutathione S-transferase-pi expression is downregulated in patients with Barrett's esophagus and esophageal adenocarcinoma. J Gastrointest Surg. 2002 May-Jun; 6(3):359-67. PMID: 12022988.
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    101. Grem JL, Danenberg KD, Kao V, Danenberg PV, Nguyen D. Biochemical and molecular effects of UCN-01 in combination with 5-fluorodeoxyuridine in A431 human epidermoid cancer cells. Anticancer Drugs. 2002 Mar; 13(3):259-70. PMID: 11984070.
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    102. Brabender J, Park J, Metzger R, Schneider PM, Lord RV, Hölscher AH, Danenberg KD, Danenberg PV. Prognostic significance of cyclooxygenase 2 mRNA expression in non-small cell lung cancer. Ann Surg. 2002 Mar; 235(3):440-3. PMID: 11882767; PMCID: PMC1422451.
    103. Formenti SC, Spicer D, Skinner K, Cohen D, Groshen S, Bettini A, Naritoku W, Press M, Salonga D, Tsao-Wei D, Danenberg K, Danenberg P. Low HER2/neu gene expression is associated with pathological response to concurrent paclitaxel and radiation therapy in locally advanced breast cancer. Int J Radiat Oncol Biol Phys. 2002 Feb 01; 52(2):397-405. PMID: 11872285.
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    104. Brabender J, Danenberg KD, Metzger R, Schneider PM, Lord RV, Groshen S, Tsao-Wei DD, Park J, Salonga D, Hölscher AH, Danenberg PV. The role of retinoid X receptor messenger RNA expression in curatively resected non-small cell lung cancer. Clin Cancer Res. 2002 Feb; 8(2):438-43. PMID: 11839661.
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    105. Usadel H, Brabender J, Danenberg KD, Jerónimo C, Harden S, Engles J, Danenberg PV, Yang S, Sidransky D. Quantitative adenomatous polyposis coli promoter methylation analysis in tumor tissue, serum, and plasma DNA of patients with lung cancer. Cancer Res. 2002 Jan 15; 62(2):371-5. PMID: 11809682.
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    106. Salonga DS, Danenberg KD, Grem J, Park JM, Danenberg PV. Relative gene expression in normal and tumor tissue by quantitative RT-PCR. Methods Mol Biol. 2002; 191:83-98. PMID: 11951611.
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    107. Shirota Y, Stoehlmacher J, Brabender J, Xiong YP, Uetake H, Danenberg KD, Groshen S, Tsao-Wei DD, Danenberg PV, Lenz HJ. ERCC1 and thymidylate synthase mRNA levels predict survival for colorectal cancer patients receiving combination oxaliplatin and fluorouracil chemotherapy. J Clin Oncol. 2001 Dec 01; 19(23):4298-304. PMID: 11731512.
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    108. Kawakami K, Salonga D, Park JM, Danenberg KD, Uetake H, Brabender J, Omura K, Watanabe G, Danenberg PV. Different lengths of a polymorphic repeat sequence in the thymidylate synthase gene affect translational efficiency but not its gene expression. Clin Cancer Res. 2001 Dec; 7(12):4096-101. PMID: 11751507.
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    109. Fu CH, Martin-Aragon S, Weinberg KI, Ardi VC, Danenberg PV, Avramis VI. Reversal of cytosine arabinoside (ara-C) resistance by the synergistic combination of 6-thioguanine plus ara-C plus PEG-asparaginase (TGAP) in human leukemia lines lacking or expressing p53 protein. Cancer Chemother Pharmacol. 2001 Aug; 48(2):123-33. PMID: 11561778.
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    110. Brabender J, Lord RV, Danenberg KD, Metzger R, Schneider PM, Park JM, Salonga D, Groshen S, Tsao-Wei DD, DeMeester TR, Hölscher AH, Danenberg PV. Increased c-myb mRNA expression in Barrett's esophagus and Barrett's-associated adenocarcinoma. J Surg Res. 2001 Aug; 99(2):301-6. PMID: 11469901.
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    111. Brabender J, Danenberg KD, Metzger R, Schneider PM, Park J, Salonga D, Hölscher AH, Danenberg PV. Epidermal growth factor receptor and HER2-neu mRNA expression in non-small cell lung cancer Is correlated with survival. Clin Cancer Res. 2001 Jul; 7(7):1850-5. PMID: 11448895.
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    112. Brabender J, Usadel H, Danenberg KD, Metzger R, Schneider PM, Lord RV, Wickramasinghe K, Lum CE, Park J, Salonga D, Singer J, Sidransky D, Hölscher AH, Meltzer SJ, Danenberg PV. Adenomatous polyposis coli gene promoter hypermethylation in non-small cell lung cancer is associated with survival. Oncogene. 2001 Jun 14; 20(27):3528-32. PMID: 11429699.
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    113. Gan Y, Mo Y, Kalns JE, Lu J, Danenberg K, Danenberg P, Wientjes MG, Au JL. Expression of DT-diaphorase and cytochrome P450 reductase correlates with mitomycin C activity in human bladder tumors. Clin Cancer Res. 2001 May; 7(5):1313-9. PMID: 11350900.
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    114. Grem JL, Danenberg KD, Behan K, Parr A, Young L, Danenberg PV, Nguyen D, Drake J, Monks A, Allegra CJ. Thymidine kinase, thymidylate synthase, and dihydropyrimidine dehydrogenase profiles of cell lines of the National Cancer Institute's Anticancer Drug Screen. Clin Cancer Res. 2001 Apr; 7(4):999-1009. PMID: 11309351.
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    115. Brabender J, Lord RV, Danenberg KD, Metzger R, Schneider PM, Uetake H, Kawakami K, Park JM, Salonga D, Peters JH, DeMeester TR, Hölscher AH, Danenberg PV. Upregulation of ornithine decarboxylase mRNA expression in Barrett's esophagus and Barrett's-associated adenocarcinoma. J Gastrointest Surg. 2001 Mar-Apr; 5(2):174-81; discussion 182. PMID: 11331481.
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    116. Lord RV, Tsai PI, Danenberg KD, Peters JH, Demeester TR, Tsao-Wei DD, Groshen S, Salonga D, Park JM, Crookes PF, Kiyabu M, Chandrasoma P, Danenberg PV. Retinoic acid receptor-alpha messenger RNA expression is increased and retinoic acid receptor-gamma expression is decreased in Barrett's intestinal metaplasia, dysplasia, adenocarcinoma sequence. Surgery. 2001 Mar; 129(3):267-76. PMID: 11231454.
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    117. Brabender J, Lenz HJ, Danenberg PV. [Molecular markers as basis for chemotherapy?]. Chirurg. 2000 Dec; 71(12):1433-9. PMID: 11195061.
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    118. Formenti S, Felix J, Salonga D, Danenberg K, Pike MC, Danenberg P. Expression of metastases-associated genes in cervical cancers resected in the proliferative and secretory phases of the menstrual cycle. Clin Cancer Res. 2000 Dec; 6(12):4653-7. PMID: 11156216.
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    119. Kawakami K, Brabender J, Lord RV, Groshen S, Greenwald BD, Krasna MJ, Yin J, Fleisher AS, Abraham JM, Beer DG, Sidransky D, Huss HT, Demeester TR, Eads C, Laird PW, Ilson DH, Kelsen DP, Harpole D, Moore MB, Danenberg KD, Danenberg PV, Meltzer SJ. Hypermethylated APC DNA in plasma and prognosis of patients with esophageal adenocarcinoma. J Natl Cancer Inst. 2000 Nov 15; 92(22):1805-11. PMID: 11078757.
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    120. Eads CA, Lord RV, Kurumboor SK, Wickramasinghe K, Skinner ML, Long TI, Peters JH, DeMeester TR, Danenberg KD, Danenberg PV, Laird PW, Skinner KA. Fields of aberrant CpG island hypermethylation in Barrett's esophagus and associated adenocarcinoma. Cancer Res. 2000 Sep 15; 60(18):5021-6. PMID: 11016622.
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    121. Link KH, Kornmann M, Butzer U, Leder G, Sunelaitis E, Pillasch J, Salonga D, Danenberg KD, Danenberg PV, Beger HG. Thymidylate synthase quantitation and in vitro chemosensitivity testing predicts responses and survival of patients with isolated nonresectable liver tumors receiving hepatic arterial infusion chemotherapy. Cancer. 2000 Jul 15; 89(2):288-96. PMID: 10918158.
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    122. Banerjee D, Gorlick R, Liefshitz A, Danenberg K, Danenberg PC, Danenberg PV, Klimstra D, Jhanwar S, Cordon-Cardo C, Fong Y, Kemeny N, Bertino JR. Levels of E2F-1 expression are higher in lung metastasis of colon cancer as compared with hepatic metastasis and correlate with levels of thymidylate synthase. Cancer Res. 2000 May 01; 60(9):2365-7. PMID: 10811110.
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    123. Eads CA, Danenberg KD, Kawakami K, Saltz LB, Blake C, Shibata D, Danenberg PV, Laird PW. MethyLight: a high-throughput assay to measure DNA methylation. Nucleic Acids Res. 2000 Apr 15; 28(8):E32. PMID: 10734209.
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    124. Salonga D, Danenberg KD, Johnson M, Metzger R, Groshen S, Tsao-Wei DD, Lenz HJ, Leichman CG, Leichman L, Diasio RB, Danenberg PV. Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase. Clin Cancer Res. 2000 Apr; 6(4):1322-7. PMID: 10778957.
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    125. Leder GH, Pillasch J, Kornmann M, Danenberg PV, Link KH. Theoretical considerations and in vitro concentration response studies with two human colorectal carcinoma cell lines. The rational experimental base for clinical studies in regional chemotherapy. Gan To Kagaku Ryoho. 2000 Apr; 27(4):565-77. PMID: 10790999.
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    126. Sirotnak FM, Danenberg KD, Chen J, Fritz F, Danenberg PV. Markedly decreased binding of vincristine to tubulin in vinca alkaloid-resistant Chinese hamster cells is associated with selective overexpression of alpha and beta tubulin isoforms. Biochem Biophys Res Commun. 2000 Mar 05; 269(1):21-4. PMID: 10694470.
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    127. Lord RV, Salonga D, Danenberg KD, Peters JH, DeMeester TR, Park JM, Johansson J, Skinner KA, Chandrasoma P, DeMeester SR, Bremner CG, Tsai PI, Danenberg PV. Telomerase reverse transcriptase expression is increased early in the Barrett's metaplasia, dysplasia, adenocarcinoma sequence. J Gastrointest Surg. 2000 Mar-Apr; 4(2):135-42. PMID: 10675236.
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    128. Lehman NL, Danenberg PV. Modulation of RTX cytotoxicity by thymidine and dipyridamole in vitro: implications for chemotherapy. Cancer Chemother Pharmacol. 2000; 45(2):142-8. PMID: 10663629.
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    129. Danenberg PV, Malli H, Swenson S. Thymidylate synthase inhibitors. Semin Oncol. 1999 Dec; 26(6):621-31. PMID: 10606255.
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    130. Abolhoda A, Wilson AE, Ross H, Danenberg PV, Burt M, Scotto KW. Rapid activation of MDR1 gene expression in human metastatic sarcoma after in vivo exposure to doxorubicin. Clin Cancer Res. 1999 Nov; 5(11):3352-6. PMID: 10589744.
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    131. Lord RV, Danenberg KD, Danenberg PV. Cyclooxygenase-2 in Barrett's esophagus, Barrett's adenocarcinomas, and esophageal SCC: ready for clinical trials. Am J Gastroenterol. 1999 Aug; 94(8):2313-5. PMID: 10445576.
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    132. Kornmann M, Danenberg KD, Arber N, Beger HG, Danenberg PV, Korc M. Inhibition of cyclin D1 expression in human pancreatic cancer cells is associated with increased chemosensitivity and decreased expression of multiple chemoresistance genes. Cancer Res. 1999 Jul 15; 59(14):3505-11. PMID: 10416617.
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    133. Eads CA, Danenberg KD, Kawakami K, Saltz LB, Danenberg PV, Laird PW. CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression. Cancer Res. 1999 May 15; 59(10):2302-6. PMID: 10344733.
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    134. Formenti SC, Symmans WF, Volm M, Skinner K, Cohen D, Spicer D, Danenberg PV. Concurrent paclitaxel and radiation therapy for breast cancer. Semin Radiat Oncol. 1999 Apr; 9(2 Suppl 1):34-42. PMID: 10210538.
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    135. Metzger R, Danenberg K, Leichman CG, Salonga D, Schwartz EL, Wadler S, Lenz HJ, Groshen S, Leichman L, Danenberg PV. High basal level gene expression of thymidine phosphorylase (platelet-derived endothelial cell growth factor) in colorectal tumors is associated with nonresponse to 5-fluorouracil. Clin Cancer Res. 1998 Oct; 4(10):2371-6. PMID: 9796967.
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    136. Ju J, Kane SE, Lenz HJ, Danenberg KD, Chu E, Danenberg PV. Desensitization and sensitization of cells to fluoropyrimidines with different antisenses directed against thymidylate synthase messenger RNA. Clin Cancer Res. 1998 Sep; 4(9):2229-36. PMID: 9748143.
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    137. Avramis VI, Nandy P, Kwock R, Solorzano MM, Mukherjee SK, Danenberg P, Cohen LJ. Increased p21/WAF-1 and p53 protein levels following sequential three drug combination regimen of fludarabine, cytarabine and docetaxel induces apoptosis in human leukemia cells. Anticancer Res. 1998 Jul-Aug; 18(4A):2327-38. PMID: 9703875.
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    138. Lenz HJ, Danenberg KD, Leichman CG, Florentine B, Johnston PG, Groshen S, Zhou L, Xiong YP, Danenberg PV, Leichman LP. p53 and thymidylate synthase expression in untreated stage II colon cancer: associations with recurrence, survival, and site. Clin Cancer Res. 1998 May; 4(5):1227-34. PMID: 9607581.
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    139. Lenz HJ, Hayashi K, Salonga D, Danenberg KD, Danenberg PV, Metzger R, Banerjee D, Bertino JR, Groshen S, Leichman LP, Leichman CG. p53 point mutations and thymidylate synthase messenger RNA levels in disseminated colorectal cancer: an analysis of response and survival. Clin Cancer Res. 1998 May; 4(5):1243-50. PMID: 9607583.
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    140. Ju JF, Banerjee D, Lenz HJ, Danenberg KD, Schmittgen TC, Spears CP, Schönthal AH, Manno DJ, Hochhauser D, Bertino JR, Danenberg PV. Restoration of wild-type p53 activity in p53-null HL-60 cells confers multidrug sensitivity. Clin Cancer Res. 1998 May; 4(5):1315-22. PMID: 9607592.
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    141. Gorlick R, Metzger R, Danenberg KD, Salonga D, Miles JS, Longo GS, Fu J, Banerjee D, Klimstra D, Jhanwar S, Danenberg PV, Kemeny N, Bertino JR. Higher levels of thymidylate synthase gene expression are observed in pulmonary as compared with hepatic metastases of colorectal adenocarcinoma. J Clin Oncol. 1998 Apr; 16(4):1465-9. PMID: 9552053.
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    142. Metzger R, Danenberg K, Hayashi K, Hölscher AH, Danenberg PV. [Expression of p16 and p16 beta in squamous epithelial carcinomas and adenocarcinomas of the esophagus: differences in regulation dependent on kind of tumor and histology]. Langenbecks Arch Chir Suppl Kongressbd. 1998; 115(Suppl I):491-4. PMID: 14518304.
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    143. Metzger R, Leichman CG, Danenberg KD, Danenberg PV, Lenz HJ, Hayashi K, Groshen S, Salonga D, Cohen H, Laine L, Crookes P, Silberman H, Baranda J, Konda B, Leichman L. ERCC1 mRNA levels complement thymidylate synthase mRNA levels in predicting response and survival for gastric cancer patients receiving combination cisplatin and fluorouracil chemotherapy. J Clin Oncol. 1998 Jan; 16(1):309-16. PMID: 9440758.
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    144. Formenti SC, Dunnington G, Uzieli B, Lenz H, Keren-Rosenberg S, Silberman H, Spicer D, Denk M, Leichman G, Groshen S, Watkins K, Muggia F, Florentine B, Press M, Danenberg K, Danenberg P. Original p53 status predicts for pathological response in locally advanced breast cancer patients treated preoperatively with continuous infusion 5-fluorouracil and radiation therapy. Int J Radiat Oncol Biol Phys. 1997 Dec 01; 39(5):1059-68. PMID: 9392545.
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    145. Leichman CG, Lenz HJ, Leichman L, Danenberg K, Baranda J, Groshen S, Boswell W, Metzger R, Tan M, Danenberg PV. Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin. J Clin Oncol. 1997 Oct; 15(10):3223-9. PMID: 9336359.
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    146. Hayashi K, Metzger R, Salonga D, Danenberg K, Leichman LP, Fink U, Sendler A, Kelsen D, Schwartz GK, Groshen S, Lenz HJ, Danenberg PV. High frequency of simultaneous loss of p16 and p16beta gene expression in squamous cell carcinoma of the esophagus but not in adenocarcinoma of the esophagus or stomach. Oncogene. 1997 Sep 18; 15(12):1481-8. PMID: 9333024.
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    147. Kornmann M, Link KH, Lenz HJ, Pillasch J, Metzger R, Butzer U, Leder GH, Weindel M, Safi F, Danenberg KD, Beger HG, Danenberg PV. Thymidylate synthase is a predictor for response and resistance in hepatic artery infusion chemotherapy. Cancer Lett. 1997 Sep 16; 118(1):29-35. PMID: 9310257.
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    148. Fisher AM, Danenberg K, Banerjee D, Bertino JR, Danenberg P, Gomer CJ. Increased photosensitivity in HL60 cells expressing wild-type p53. Photochem Photobiol. 1997 Aug; 66(2):265-70. PMID: 9277147.
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    149. Lenz HJ, Leichman CG, Danenberg KD, Danenberg PV, Groshen S, Cohen H, Laine L, Crookes P, Silberman H, Baranda J, Garcia Y, Li J, Leichman L. Thymidylate synthase mRNA level in adenocarcinoma of the stomach: a predictor for primary tumor response and overall survival. J Clin Oncol. 1996 Jan; 14(1):176-82. PMID: 8558194.
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    150. Lenz HJ, Danenberg KD, Schnieders B, Banerjee D, Bertino JR, Leichman L, Danenberg PV. Identification of mutations by RNA conformational polymorphism "bar code" analysis. Genomics. 1995 Nov 01; 30(1):120-2. PMID: 8595893.
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    151. Banerjee D, Lenz HJ, Schnieders B, Manno DJ, Ju JF, Spears CP, Hochhauser D, Danenberg K, Danenberg P, Bertino JR. Transfection of wild-type but not mutant p53 induces early monocytic differentiation in HL60 cells and increases their sensitivity to stress. Cell Growth Differ. 1995 Nov; 6(11):1405-13. PMID: 8562479.
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    152. Johnston PG, Lenz HJ, Leichman CG, Danenberg KD, Allegra CJ, Danenberg PV, Leichman L. Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors. Cancer Res. 1995 Apr 01; 55(7):1407-12. PMID: 7882343.
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    153. Lenz HJ, Hill C, Danenberg KD, Leichman LL, Priest DG, Danenberg PV. Rapid quantitative PCR for determination of relative gene expressions in tissue specimens. PCR Methods Appl. 1995 Apr; 4(5):305-8. PMID: 7580920.
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    154. Wang SJ, Scavetta R, Lenz HJ, Danenberg K, Danenberg PV, Schönthal AH. Gene amplification and multidrug resistance induced by the phosphatase-inhibitory tumor promoter, okadaic acid. Carcinogenesis. 1995 Mar; 16(3):637-41. PMID: 7697825.
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    155. Lenz HJ, Manno DJ, Danenberg KD, Danenberg PV. Incorporation of 5-fluorouracil into U2 and U6 snRNA inhibits mRNA precursor splicing. J Biol Chem. 1994 Dec 16; 269(50):31962-8. PMID: 7989372.
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    156. Horikoshi T, Lenz HJ, Danenberg K, Koch OM, Bertino JR, Danenberg PV. Quantitative determination of the ratio of mutated to normal ras genes in the blood of leukemia patients by allele-specific PCR. Leuk Res. 1994 Sep; 18(9):693-702. PMID: 7934145.
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    157. Schmittgen TD, Danenberg KD, Horikoshi T, Lenz HJ, Danenberg PV. Effect of 5-fluoro- and 5-bromouracil substitution on the translation of human thymidylate synthase mRNA. J Biol Chem. 1994 Jun 10; 269(23):16269-75. PMID: 8206932.
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    158. Koch OM, Volkenandt M, Göker E, Buer J, Probst M, Banerjee D, Danenberg PV, Bertino JR. Molecular detection and characterization of clonal cell populations in acute lymphocytic leukemia by analysis of conformational polymorphisms of cRNA molecules of rearranged T-cell-receptor-gamma and immunoglobulin heavy-chain genes. Leukemia. 1994 Jun; 8(6):946-52. PMID: 8207989.
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    159. Koch OM, Probst M, Tiemann M, Jakob I, Volkenandt M, Wienecke R, Buer J, Atzpodien J, Lenz HJ, Danenberg PV. Detection of clonal T-cell populations in gastrointestinal lymphomas by analysis of cRNA conformational polymorphisms of rearranged T-cell-receptor-gamma genes. Br J Haematol. 1994 Feb; 86(2):316-21. PMID: 8199020.
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    160. Lenz HJ, Danenberg K, Schnieders B, Goeker E, Peters GJ, Garrow T, Shane B, Bertino JR, Danenberg PV. Quantitative analysis of folylpolyglutamate synthetase gene expression in tumor tissues by the polymerase chain reaction: marked variation of expression among leukemia patients. Oncol Res. 1994; 6(7):329-35. PMID: 7865908.
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    161. Kan-Mitchell J, Liggett PE, Taylor CR, Rao N, Granada ES, Danenberg KD, White WL, Van Eldik LJ, Horikoshi T, Danenberg PV. Differential S100 beta expression in choroidal and skin melanomas: quantitation by the polymerase chain reaction. Invest Ophthalmol Vis Sci. 1993 Nov; 34(12):3366-75. PMID: 8225871.
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    162. Volkenandt M, Wienecke R, Koch OM, Buer J, Probst M, Atzpodien J, Horikoshi T, Danenberg K, Danenberg P, Bertino JR. Conformational polymorphisms of cRNA of T-cell-receptor genes as a clone-specific molecular marker for cutaneous lymphoma. J Invest Dermatol. 1993 Oct; 101(4):514-6. PMID: 8409516.
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    163. Wienecke R, Volkenandt M, Koch O, Neubert U, McNutt NS, Danenberg PV, Bertino JR. Rapid and sensitive molecular subtyping of microorganisms in clinical specimens. Lancet. 1993 Mar 27; 341(8848):830-1. PMID: 7681136.
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    164. Miyamoto H, Kubota Y, Shuin T, Torigoe S, Hosaka M, Iwasaki Y, Danenberg K, Danenberg PV. Analyses of p53 gene mutations in primary human bladder cancer. Oncol Res. 1993; 5(6-7):245-9. PMID: 8123944.
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    165. Horikoshi T, Danenberg K, Volkenandt M, Stadlbauer T, Danenberg PV. Quantitative measurement of relative gene expression in human tumors. Methods Mol Biol. 1993; 15:177-88. PMID: 21400275.
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    166. Volkenandt M, Dicker AP, Banerjee D, Fanin R, Schweitzer B, Horikoshi T, Danenberg K, Danenberg P, Bertino JR. Quantitation of gene copy number and mRNA using the polymerase chain reaction. Proc Soc Exp Biol Med. 1992 May; 200(1):1-6. PMID: 1570351.
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    167. Traver RD, Horikoshi T, Danenberg KD, Stadlbauer TH, Danenberg PV, Ross D, Gibson NW. NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity. Cancer Res. 1992 Feb 15; 52(4):797-802. PMID: 1737339.
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    168. Danenberg PV, Horikoshi T, Volkenandt M, Danenberg K, Lenz HJ, Shea LC, Dicker AP, Simoneau A, Jones PA, Bertino JR. Detection of point mutations in human DNA by analysis of RNA conformation polymorphism(s). Nucleic Acids Res. 1992 Feb 11; 20(3):573-9. PMID: 1371351.
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    169. Torigoe S, Shuin T, Kubota Y, Horikoshi T, Danenberg K, Danenberg PV. p53 gene mutation in primary human renal cell carcinoma. Oncol Res. 1992; 4(11-12):467-72. PMID: 1299377.
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    170. Danenberg PV, Shea LC, Danenberg KD, Horikoshi T. Inactivation of Tetrahymena rRNA self-splicing by cis-platin proceeds through dissociable complexes. Nucleic Acids Res. 1991 Jun 11; 19(11):3123-8. PMID: 1905401.
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    171. Danenberg PV, Shea LC, Danenberg K. Effect of 5-fluorouracil substitution on the self-splicing activity of Tetrahymena ribosomal RNA. Cancer Res. 1990 Mar 15; 50(6):1757-63. PMID: 2407343.
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    172. Spears CP, Hayes AA, Shahinian AH, Danenberg PV, Frösing R, Gustavsson BG. Deoxyuridylate effects on thymidylate synthase-5-fluorodeoxyuridylate-folate ternary complex formation. Biochem Pharmacol. 1989 Sep 15; 38(18):2985-93. PMID: 2783153.
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    173. Danenberg PV, Shea LC, Danenberg K. Characterization of the mode of binding of substrates to the active site of Tetrahymena self-splicing RNA using 5-fluorouracil-substituted mini-exons. Biochemistry. 1989 Aug 08; 28(16):6779-85. PMID: 2675974.
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    174. Danenberg KD, Danenberg PV. Activity of thymidylate synthetase and its inhibition by 5-fluorouracil in highly enzyme-overproducing cells resistant to 10-propargyl-5,8-dideazafolate. Mol Pharmacol. 1989 Aug; 36(2):219-23. PMID: 2528057.
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    175. Ajmera S, Bapat AR, Stephanian E, Danenberg PV. Synthesis and interaction with uridine phosphorylase of 5'-deoxy-4',5-difluorouridine, a new prodrug of 5-fluorouracil. J Med Chem. 1988 Jun; 31(6):1094-8. PMID: 2967375.
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    176. Link KH, Aigner KR, Peschau K, Warthona M, Schwemmle K, Danenberg PV. Concentration and time dependence of the toxicity of fluorinated pyrimidines to HT 29 colorectal carcinoma cells. Cancer Chemother Pharmacol. 1988; 22(1):58-62. PMID: 2969305.
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    177. Rosowsky A, Forsch RA, Freisheim JH, Danenberg PV, Moran RG, Wick MM. Methotrexate analogues. 29. Effect of gamma-aminobutyric acid spacers between the pteroyl and glutamate moieties on enzyme binding and cell growth inhibition. J Med Chem. 1986 Oct; 29(10):1872-6. PMID: 2428979.
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    178. Pogolotti AL, Danenberg PV, Santi DV. Kinetics and mechanism of interaction of 10-propargyl-5,8-dideazafolate with thymidylate synthase. J Med Chem. 1986 Apr; 29(4):478-82. PMID: 3754285.
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    179. Pellino AM, Danenberg PV. Evidence from chemical degradation studies for a covalent bond from 5-fluoro-2'-deoxyuridylate to N-5 of tetrahydrofolate in the ternary complex of thymidylate synthetase-5-fluoro-2'-deoxyuridylate-5,10-methylenetetrahydrofolate. J Biol Chem. 1985 Sep 15; 260(20):10996-1000. PMID: 3928628.
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    180. Spears CP, Shani J, Shahinian AH, Wolf W, Heidelberger C, Danenberg PV. Assay and time course of 5-fluorouracil incorporation into RNA of L1210/0 ascites cells in vivo. Mol Pharmacol. 1985 Feb; 27(2):302-7. PMID: 2578605.
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    181. Peterson AR, Danenberg PV, Ibric LL, Peterson H. Deoxyribonucleoside-induced selective modulation of cytotoxicity and mutagenesis. Basic Life Sci. 1985; 31:313-34. PMID: 3158302.
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    182. Lockshin A, Mondal K, Danenberg PV. Spectroscopic studies of ternary complexes of thymidylate synthetase, deoxyribonucleotides, and folate analogs. J Biol Chem. 1984 Sep 25; 259(18):11346-52. PMID: 6236224.
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    183. Spears CP, Gustavsson BG, Mitchell MS, Spicer D, Berne M, Bernstein L, Danenberg PV. Thymidylate synthetase inhibition in malignant tumors and normal liver of patients given intravenous 5-fluorouracil. Cancer Res. 1984 Sep; 44(9):4144-50. PMID: 6744325.
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    184. Shani J, Danenberg PV. Evidence that intracellular synthesis of 5-fluorouridine-5'-phosphate from 5-fluorouracil and 5-fluorouridine is compartmentalized. Biochem Biophys Res Commun. 1984 Jul 18; 122(1):439-45. PMID: 6743344.
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    185. Danenberg KD, Becker D, Mulkins MA, Danenberg PV. Studies on the mechanism of fluoropyrimidine cytotoxicity in l1210 cells: correlation with inhibition of thymidylate synthetase but not with incorporation into RNA. Pharm Res. 1984 May; 1(3):110-5. PMID: 24277246.
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    186. Ajmera S, Bapat AR, Danenberg K, Danenberg PV. Synthesis and biological activity of 5-fluoro-2',3'-dideoxy-3'-fluorouridine and its 5'-phosphate. J Med Chem. 1984 Jan; 27(1):11-4. PMID: 6228661.
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    187. Bapat AR, Zarow C, Danenberg PV. Human leukemic cells resistant to 5-fluoro-2'-deoxyuridine contain a thymidylate synthetase with lower affinity for nucleotides. J Biol Chem. 1983 Apr 10; 258(7):4130-6. PMID: 6220000.
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    188. Peterson AR, Peterson H, Danenberg PV. Induction of mutations by 5-fluorodeoxyuridine: a mechanism of self-potentiated drug resistance? Biochem Biophys Res Commun. 1983 Jan 27; 110(2):573-7. PMID: 6220701.
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    189. Heidelberger C, Danenberg PV, Moran RG. Fluorinated pyrimidines and their nucleosides. Adv Enzymol Relat Areas Mol Biol. 1983; 54:58-119. PMID: 6189380.
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    190. Moran RG, Danenberg PV, Heidelberger C. Therapeutic response of leukemic mice treated with fluorinated pyrimidines and inhibitors of deoxyuridylate synthesis. Biochem Pharmacol. 1982 Sep 15; 31(18):2929-35. PMID: 6215922.
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    191. Ajmera S, Danenberg PV. Synthesis and biological activity of 5'-substituted 5-fluoropyrimidine nucleosides. J Med Chem. 1982 Aug; 25(8):999-1002. PMID: 7120290.
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    192. Danenberg PV, Lockshin A. Thymidylate synthetase - substrate complex formation. Mol Cell Biochem. 1982 Mar 05; 43(1):49-57. PMID: 7078549.
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    193. Danenberg PV, Lockshin A. Tight-binding complexes of thymidylate synthetase, folate analogs and deoxyribonucleotides. Adv Enzyme Regul. 1982; 20:99-110. PMID: 6810659.
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    194. Zarow C, Pellino AM, Danenberg PV. Large-scale and small-scale methods for the preparation of 5,10-methylenetetrahydrofolate. Prep Biochem. 1982; 12(5):381-93. PMID: 6820505.
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    195. Danenberg PV, Bhatt RS, Kundu NG, Danenberg K, Heidelberger C. Interaction of 5-ethynyl-2'-deoxyuridylate with thymidylate synthetase. J Med Chem. 1981 Dec; 24(12):1537-40. PMID: 6796692.
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    196. Danenberg PV, Heidelberger C, Mulkins MA, Peterson AR. The incorporation of 5-fluoro-2'-deoxyuridine into DNA of mammalian tumor cells. Biochem Biophys Res Commun. 1981 Sep 30; 102(2):654-8. PMID: 6458299.
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    197. Lockshin A, Danenberg PV. Biochemical factors affecting the tightness of 5-fluorodeoxyuridylate binding to human thymidylate synthetase. Biochem Pharmacol. 1981 Feb 01; 30(3):247-57. PMID: 6939434.
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    198. Danenberg PV, Lockshin A. Fluorinated pyrimidines as tight-binding inhibitors of thymidylate synthetase. Pharmacol Ther. 1981; 13(1):69-90. PMID: 6455671.
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    199. Phelps ME, Woodman PW, Danenberg PV. Synthesis and biological activity of 5-fluoro-2'-deoxyuridine 5'-phosphorodiamidates. J Med Chem. 1980 Nov; 23(11):1229-32. PMID: 6779007.
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    200. Lockshin A, Danenberg PV. Hydrodynamic behavior of human and bacterial thymidylate synthetases and thymidylate synthetase--5-fluoro-2'-deoxyuridylate--5,10-methylenetetrahydrofolate complexes. Evidence for large conformational changes during catalysis. Biochemistry. 1980 Sep 02; 19(18):4244-51. PMID: 6932226.
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    201. Sarrif AM, Tone H, Danenberg PV, Heidelberger C. The incorporation of trifluorothymidine into calf thymus DNA in a cell-free system does not lead to chain termination. Mol Pharmacol. 1980 Jul; 18(1):148-50. PMID: 6774228.
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    202. Lockshin A, Danenberg PV. Thymidylate synthetase and 2'-deoxyuridylate form a tight complex in the presence of pteroyltriglutamate. J Biol Chem. 1979 Dec 25; 254(24):12285-8. PMID: 115883.
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    203. Danenberg KD, Danenberg PV. Evidence for a sequential interaction of the subunits of thymidylate synthetase. J Biol Chem. 1979 Jun 10; 254(11):4345-8. PMID: 108277.
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    204. Lockshin A, Moran RG, Danenberg PV. Thymidylate synthetase purified to homogeneity from human leukemic cells. Proc Natl Acad Sci U S A. 1979 Feb; 76(2):750-4. PMID: 34155.
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    205. Danenberg PV, Danenberg KD. Effect of 5, 10-methylenetetrahydrofolate on the dissociation of 5-fluoro-2'-deoxyuridylate from thymidylate synthetase: evidence for an ordered mechanism. Biochemistry. 1978 Sep 19; 17(19):4018-24. PMID: 101234.
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    206. Danenberg PV, Danenberg KD, Cleland WW. The interaction of liver alcohol dehydrogenase with phenyl adenine dinucleotide, a novel analog of pyridine nucleotide coenzymes. J Biol Chem. 1978 Sep 10; 253(17):5886-7. PMID: 210161.
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    207. Danenberg PV. Thymidylate synthetase - a target enzyme in cancer chemotherapy. Biochim Biophys Acta. 1977 Dec 23; 473(2):73-92. PMID: 145246.
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    208. Danenberg PV, Danenberg KD. Inhibition of hexokinase by multisubstrate analogs. Biochim Biophys Acta. 1977 Feb 09; 480(2):351-6. PMID: 836847.
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    209. Sarrif AM, Danenberg PV, Heidelberger C. Separate identities of ligandin and the h-protein, a major protein to which carcinogenic hydrocarbons are covalently bound. Biochem Biophys Res Commun. 1976 Jun 07; 70(3):869-77. PMID: 820342.
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    210. Chwang TL, Wood WF, Parkhurst JR, Nesnow S, Danenberg PV, Heidelberger C. Synthesis and biological studies of 3-(beta-D-ribofuranosyl)-2,3,-dihydro-6H-1,3-oxazine-2,6-dione, a new pyrimidine nucleoside analog related to uridine. J Med Chem. 1976 May; 19(5):643-7. PMID: 178870.
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    211. Danenberg PV, Heidelberger C. The effect of Raney nickel on the covalent thymidylate synthetase-5-fluoro-2'-deoxyuridylate-5,10-methylenetetrahydrofolate complex. Biochemistry. 1976 Mar 23; 15(6):1331-7. PMID: 1252451.
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    212. Parkhurst JR, Danenberg PV, Heidelberger C. Growth inhibition of cells in cultures and of vaccinia virus infected HeLa cells by derivatives of trifluorothymidine. Chemotherapy. 1976; 22(3-4):221-31. PMID: 178485.
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    213. Danenberg PV, Santi DV. Inhibition of phenylalanyl-tRNA synthetase by aromatic guanidines and amidines. J Med Chem. 1975 May; 18(5):528-30. PMID: 1097688.
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    214. Danenberg PV, Langenbach RJ, Heidelberger C. Structures of reversible and irreversible complexes of thymidylate synthetase and fluorinated pyrimidine nucleotides. Biochemistry. 1974 Feb 26; 13(5):926-33. PMID: 4205029.
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    215. Danenberg PV, Heidelberger C. Purification of thymidylate synthetase with 2'-deoxyuridylate-agarose. Methods Enzymol. 1974; 34:520-3. PMID: 4217422.
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    216. Danenberg PV, Heidelberger C. Synthesis of 5-trifluoromethyl-2'-deoxyuridine 5'-phosphate and 5-trifluoromethyl-2'-deoxyuridine 5'-triphosphate. J Med Chem. 1973 Jun; 16(6):712-4. PMID: 4351734.
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    217. Danenberg PV, Langenbach RJ, Heidelberger C. Purification of thymidylate synthetase from L. casei by affinity chromatography. Biochem Biophys Res Commun. 1972 Nov 15; 49(4):1029-33. PMID: 4629809.
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    218. Langenbach RJ, Danenberg PV, Heidelberger C. Thymidylate synthetase: mechanism of inhibition by 5-fluoro-2'-deoxyuridylate. Biochem Biophys Res Commun. 1972 Sep 26; 48(6):1565-71. PMID: 4263280.
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    219. Santi DV, Danenberg PV, Montgomery KA. Phenylalanyl transfer ribonucleic acid synthetase from Escherichia coli. Analysis of the adenosine triphosphate binding site. Biochemistry. 1971 Dec 07; 10(25):4821-4. PMID: 4334587.
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    220. Santi DV, Danenberg PV. Phenylalanyl transfer ribonucleic acid synthetase from Escherichia coli. Analysis of the phenylalanine binding site. Biochemistry. 1971 Dec 07; 10(25):4813-20. PMID: 4334586.
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    221. Santi DV, Danenberg PV, Satterly P. Phenylalanyl transfer ribonucleic acid synthetase from Escherichia coli. Reaction parameters and order of substrate addition. Biochemistry. 1971 Dec 07; 10(25):4804-12. PMID: 4334585.
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