Norman Arnheim, PhD

Title(s)Distinguished Professor of Biological Sciences and Biochemistry and Molecular Biology, and Ester Dornsife Chair in Biological Sciences
AddressRRI 319C
University Park Campus
Los Angeles CA 90089-2910
Phone+1 213 740 7675
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    Collapse Research 
    Collapse Research Activities and Funding
    MITOCHONDRIAL DNA MUTATION AND AGING
    NIH R01AG011492May 1, 1993 - Apr 30, 1996
    Role: Principal Investigator
    GENETIC AND MOLECULAR STUDIES OF RDNA
    NIH R01GM042942Jul 1, 1989 - Jun 30, 1992
    Role: Principal Investigator
    GENETIC AND MOLECULAR STUDIES OF RDNA
    NIH R01HG000328Jul 1, 1989 - Jun 30, 1992
    Role: Principal Investigator
    Genetic Analysis Using Sperm Typing
    NIH R01GM036745Sep 1, 1985 - Aug 31, 2019
    Role: Principal Investigator
    GENETICS STUDIES USING SPERM TYPING
    NIH R37GM036745Sep 1, 1985 - Mar 31, 2002
    Role: Principal Investigator
    MOLECULAR MECHANISMS OF DNA TRANSPOSITION
    NIH R01AI019036Apr 1, 1982 - Dec 31, 1996
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Estimating Exceptionally Rare Germline and Somatic Mutation Frequencies via Next Generation Sequencing. PLoS One. 2016; 11(6):e0158340. Eboreime J, Choi SK, Yoon SR, Arnheim N, Calabrese P. PMID: 27341568.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    2. Germline Stem Cell Competition, Mutation Hot Spots, Genetic Disorders, and Older Fathers. Annu Rev Genomics Hum Genet. 2016 08 31; 17:219-43. Arnheim N, Calabrese P. PMID: 27070266.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    3. New evidence for positive selection helps explain the paternal age effect observed in achondroplasia. Hum Mol Genet. 2013 Oct 15; 22(20):4117-26. Shinde DN, Elmer DP, Calabrese P, Boulanger J, Arnheim N, Tiemann-Boege I. PMID: 23740942.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    4. Age-dependent germline mosaicism of the most common noonan syndrome mutation shows the signature of germline selection. Am J Hum Genet. 2013 Jun 06; 92(6):917-26. Yoon SR, Choi SK, Eboreime J, Gelb BD, Calabrese P, Arnheim N. PMID: 23726368.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    5. Positive selection for new disease mutations in the human germline: evidence from the heritable cancer syndrome multiple endocrine neoplasia type 2B. PLoS Genet. 2012; 8(2):e1002420. Choi SK, Yoon SR, Calabrese P, Arnheim N. PMID: 22359510.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    6. Product length, dye choice, and detection chemistry in the bead-emulsion amplification of millions of single DNA molecules in parallel. Anal Chem. 2009 Jul 15; 81(14):5770-6. Tiemann-Boege I, Curtis C, Shinde DN, Goodman DB, Tavaré S, Arnheim N. PMID: 19601653.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    7. The ups and downs of mutation frequencies during aging can account for the Apert syndrome paternal age effect. PLoS Genet. 2009 Jul; 5(7):e1000558. Yoon SR, Qin J, Glaser RL, Jabs EW, Wexler NS, Sokol R, Arnheim N, Calabrese P. PMID: 19593369.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    8. Understanding what determines the frequency and pattern of human germline mutations. Nat Rev Genet. 2009 Jul; 10(7):478-88. Arnheim N, Calabrese P. PMID: 19488047.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    9. Detection of meiotic DNA breaks in mouse testicular germ cells. Methods Mol Biol. 2009; 557:165-81. Qin J, Subramanian J, Arnheim N. PMID: 19799182.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    10. A germ-line-selective advantage rather than an increased mutation rate can explain some unexpectedly common human disease mutations. Proc Natl Acad Sci U S A. 2008 Jul 22; 105(29):10143-8. Choi SK, Yoon SR, Calabrese P, Arnheim N. PMID: 18632557.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    11. The molecular anatomy of spontaneous germline mutations in human testes. PLoS Biol. 2007 Sep; 5(9):e224. Qin J, Calabrese P, Tiemann-Boege I, Shinde DN, Yoon SR, Gelfand D, Bauer K, Arnheim N. PMID: 17760502.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    12. Triplet repeat mutation length gains correlate with cell-type specific vulnerability in Huntington disease brain. Hum Mol Genet. 2007 May 15; 16(10):1133-42. Shelbourne PF, Keller-McGandy C, Bi WL, Yoon SR, Dubeau L, Veitch NJ, Vonsattel JP, Wexler NS, US-Venezuela Collaborative Research Group , Arnheim N, Augood SJ. PMID: 17409200.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimalsCells
    13. Mammalian meiotic recombination hot spots. Annu Rev Genet. 2007; 41:369-99. Arnheim N, Calabrese P, Tiemann-Boege I. PMID: 18076329.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    14. Combining sperm typing and linkage disequilibrium analyses reveals differences in selective pressures or recombination rates across human populations. Genetics. 2007 Feb; 175(2):795-804. Clark VJ, Ptak SE, Tiemann I, Qian Y, Coop G, Stone AC, Przeworski M, Arnheim N, Di Rienzo A. PMID: 17151245.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    15. High-resolution recombination patterns in a region of human chromosome 21 measured by sperm typing. PLoS Genet. 2006 May; 2(5):e70. Tiemann-Boege I, Calabrese P, Cochran DM, Sokol R, Arnheim N. PMID: 16680198.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    16. Differential contributions of mammalian Rad54 paralogs to recombination, DNA damage repair, and meiosis. Mol Cell Biol. 2006 Feb; 26(3):976-89. Wesoly J, Agarwal S, Sigurdsson S, Bussen W, Van Komen S, Qin J, van Steeg H, van Benthem J, Wassenaar E, Baarends WM, Ghazvini M, Tafel AA, Heath H, Galjart N, Essers J, Grootegoed JA, Arnheim N, Bezzubova O, Buerstedde JM, Sung P, Kanaar R. PMID: 16428451.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    17. Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse. Cancer Res. 2005 Oct 01; 65(19):8662-70. Chen PC, Dudley S, Hagen W, Dizon D, Paxton L, Reichow D, Yoon SR, Yang K, Arnheim N, Liskay RM, Lipkin SM. PMID: 16204034.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    18. Genetic instability induced by overexpression of DNA ligase I in budding yeast. Genetics. 2005 Oct; 171(2):427-41. Subramanian J, Vijayakumar S, Tomkinson AE, Arnheim N. PMID: 15965249.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    19. Cognition and anatomy in three variants of primary progressive aphasia. Ann Neurol. 2004 Mar; 55(3):335-46. Gorno-Tempini ML, Dronkers NF, Rankin KP, Ogar JM, Phengrasamy L, Rosen HJ, Johnson JK, Weiner MW, Miller BL. PMID: 14993615.
      View in: PubMed   Mentions: 225     Fields:    Translation:HumansCells
    20. Mouse strains with an active H2-Ea meiotic recombination hot spot exhibit increased levels of H2-Ea-specific DNA breaks in testicular germ cells. Mol Cell Biol. 2004 Feb; 24(4):1655-66. Qin J, Richardson LL, Jasin M, Handel MA, Arnheim N. PMID: 14749381.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    21. Single-molecule analysis of the hypermutable tetranucleotide repeat locus D21S1245 through sperm genotyping: a heterogeneous pattern of mutation but no clear male age effect. Mol Biol Evol. 2004 Jan; 21(1):58-64. Brohede J, Arnheim N, Ellegren H. PMID: 14530459.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    22. Huntington disease expansion mutations in humans can occur before meiosis is completed. Proc Natl Acad Sci U S A. 2003 Jul 22; 100(15):8834-8. Yoon SR, Dubeau L, de Young M, Wexler NS, Arnheim N. PMID: 12857955.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    23. Hot and cold spots of recombination in the human genome: the reason we should find them and how this can be achieved. Am J Hum Genet. 2003 Jul; 73(1):5-16. Arnheim N, Calabrese P, Nordborg M. PMID: 12772086.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    24. Candidate DNA replication initiation regions at human trinucleotide repeat disease loci. Hum Mol Genet. 2003 May 01; 12(9):1021-8. Nenguke T, Aladjem MI, Gusella JF, Wexler NS, Arnheim N, Venezuela HD Project . PMID: 12700170.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    25. Taq DNA polymerase slippage mutation rates measured by PCR and quasi-likelihood analysis: (CA/GT)n and (A/T)n microsatellites. Nucleic Acids Res. 2003 Feb 01; 31(3):974-80. Shinde D, Lai Y, Sun F, Arnheim N. PMID: 12560493.
      View in: PubMed   Mentions: 72     Fields:    Translation:Cells
    26. The mutation process of microsatellites during the polymerase chain reaction. J Comput Biol. 2003; 10(2):143-55. Lai Y, Shinde D, Arnheim N, Sun F. PMID: 12804088.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    27. The observed human sperm mutation frequency cannot explain the achondroplasia paternal age effect. Proc Natl Acad Sci U S A. 2002 Nov 12; 99(23):14952-7. Tiemann-Boege I, Navidi W, Grewal R, Cohn D, Eskenazi B, Wyrobek AJ, Arnheim N. PMID: 12397172.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    28. Single-sperm typing. Curr Protoc Hum Genet. 2002 May; Chapter 1:Unit 1.6. Lien S, Szyda J, Leeflang EP, Hubert R, Zhang L, Schmitt K, Arnheim N. PMID: 18428321.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
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    NIH Funding Acknowledgment: Important - All publications resulting from the utilization of SC CTSI resources are required to credit the SC CTSI grant by including the NIH funding acknowledgment and must comply with the NIH Public Access Policy.

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