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Norman Arnheim, PhD

Title(s)Distinguished Professor of Biological Sciences and Biochemistry and Molecular Biology, and Ester Dornsife Chair in Biological Sciences
Phone+1 213 740 7675
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    Collapse Research Activities and Funding
    MITOCHONDRIAL DNA MUTATION AND AGING
    NIH/NIA R01AG011492May 1, 1993 - Apr 30, 1996
    Role: Principal Investigator
    GENETIC AND MOLECULAR STUDIES OF RDNA
    NIH/NIGMS R01GM042942Jul 1, 1989 - Jun 30, 1992
    Role: Principal Investigator
    GENETIC AND MOLECULAR STUDIES OF RDNA
    NIH/NHGRI R01HG000328Jul 1, 1989 - Jun 30, 1992
    Role: Principal Investigator
    Genetic Analysis Using Sperm Typing
    NIH/NIGMS R01GM036745Sep 1, 1985 - Mar 31, 2006
    Role: Principal Investigator
    GENETICS STUDIES USING SPERM TYPING
    NIH/NIGMS R37GM036745Sep 1, 1985 - Mar 31, 2002
    Role: Principal Investigator
    MOLECULAR MECHANISMS OF DNA TRANSPOSITION
    NIH/NIAID R01AI019036Apr 1, 1982 - Jan 31, 1996
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Eboreime J, Choi SK, Yoon SR, Arnheim N, Calabrese P. Estimating Exceptionally Rare Germline and Somatic Mutation Frequencies via Next Generation Sequencing. PLoS One. 2016; 11(6):e0158340. PMID: 27341568.
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    2. Arnheim N, Calabrese P. Germline Stem Cell Competition, Mutation Hot Spots, Genetic Disorders, and Older Fathers. Annu Rev Genomics Hum Genet. 2016 08 31; 17:219-43. PMID: 27070266.
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    3. Shinde DN, Elmer DP, Calabrese P, Boulanger J, Arnheim N, Tiemann-Boege I. New evidence for positive selection helps explain the paternal age effect observed in achondroplasia. Hum Mol Genet. 2013 Oct 15; 22(20):4117-26. PMID: 23740942.
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    4. Yoon SR, Choi SK, Eboreime J, Gelb BD, Calabrese P, Arnheim N. Age-dependent germline mosaicism of the most common noonan syndrome mutation shows the signature of germline selection. Am J Hum Genet. 2013 Jun 06; 92(6):917-26. PMID: 23726368.
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    5. Choi SK, Yoon SR, Calabrese P, Arnheim N. Positive selection for new disease mutations in the human germline: evidence from the heritable cancer syndrome multiple endocrine neoplasia type 2B. PLoS Genet. 2012; 8(2):e1002420. PMID: 22359510.
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    6. Tiemann-Boege I, Curtis C, Shinde DN, Goodman DB, Tavaré S, Arnheim N. Product length, dye choice, and detection chemistry in the bead-emulsion amplification of millions of single DNA molecules in parallel. Anal Chem. 2009 Jul 15; 81(14):5770-6. PMID: 19601653.
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    7. Yoon SR, Qin J, Glaser RL, Jabs EW, Wexler NS, Sokol R, Arnheim N, Calabrese P. The ups and downs of mutation frequencies during aging can account for the Apert syndrome paternal age effect. PLoS Genet. 2009 Jul; 5(7):e1000558. PMID: 19593369.
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    8. Arnheim N, Calabrese P. Understanding what determines the frequency and pattern of human germline mutations. Nat Rev Genet. 2009 Jul; 10(7):478-88. PMID: 19488047.
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    9. Qin J, Subramanian J, Arnheim N. Detection of meiotic DNA breaks in mouse testicular germ cells. Methods Mol Biol. 2009; 557:165-81. PMID: 19799182.
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    10. Choi SK, Yoon SR, Calabrese P, Arnheim N. A germ-line-selective advantage rather than an increased mutation rate can explain some unexpectedly common human disease mutations. Proc Natl Acad Sci U S A. 2008 Jul 22; 105(29):10143-8. PMID: 18632557.
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    11. Qin J, Calabrese P, Tiemann-Boege I, Shinde DN, Yoon SR, Gelfand D, Bauer K, Arnheim N. The molecular anatomy of spontaneous germline mutations in human testes. PLoS Biol. 2007 Sep; 5(9):e224. PMID: 17760502.
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    12. Shelbourne PF, Keller-McGandy C, Bi WL, Yoon SR, Dubeau L, Veitch NJ, Vonsattel JP, Wexler NS, Arnheim N, Augood SJ. Triplet repeat mutation length gains correlate with cell-type specific vulnerability in Huntington disease brain. Hum Mol Genet. 2007 May 15; 16(10):1133-42. PMID: 17409200.
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    13. Arnheim N, Calabrese P, Tiemann-Boege I. Mammalian meiotic recombination hot spots. Annu Rev Genet. 2007; 41:369-99. PMID: 18076329.
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    14. Clark VJ, Ptak SE, Tiemann I, Qian Y, Coop G, Stone AC, Przeworski M, Arnheim N, Di Rienzo A. Combining sperm typing and linkage disequilibrium analyses reveals differences in selective pressures or recombination rates across human populations. Genetics. 2007 Feb; 175(2):795-804. PMID: 17151245.
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    15. Tiemann-Boege I, Calabrese P, Cochran DM, Sokol R, Arnheim N. High-resolution recombination patterns in a region of human chromosome 21 measured by sperm typing. PLoS Genet. 2006 May; 2(5):e70. PMID: 16680198.
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    16. Wesoly J, Agarwal S, Sigurdsson S, Bussen W, Van Komen S, Qin J, van Steeg H, van Benthem J, Wassenaar E, Baarends WM, Ghazvini M, Tafel AA, Heath H, Galjart N, Essers J, Grootegoed JA, Arnheim N, Bezzubova O, Buerstedde JM, Sung P, Kanaar R. Differential contributions of mammalian Rad54 paralogs to recombination, DNA damage repair, and meiosis. Mol Cell Biol. 2006 Feb; 26(3):976-89. PMID: 16428451.
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    17. Chen PC, Dudley S, Hagen W, Dizon D, Paxton L, Reichow D, Yoon SR, Yang K, Arnheim N, Liskay RM, Lipkin SM. Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse. Cancer Res. 2005 Oct 01; 65(19):8662-70. PMID: 16204034.
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    18. Subramanian J, Vijayakumar S, Tomkinson AE, Arnheim N. Genetic instability induced by overexpression of DNA ligase I in budding yeast. Genetics. 2005 Oct; 171(2):427-41. PMID: 15965249.
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    19. Wexler NS, Lorimer J, Porter J, Gomez F, Moskowitz C, Shackell E, Marder K, Penchaszadeh G, Roberts SA, Gayán J, Brocklebank D, Cherny SS, Cardon LR, Gray J, Dlouhy SR, Wiktorski S, Hodes ME, Conneally PM, Penney JB, Gusella J, Cha JH, Irizarry M, Rosas D, Hersch S, Hollingsworth Z, MacDonald M, Young AB, Andresen JM, Housman DE, De Young MM, Bonilla E, Stillings T, Negrette A, Snodgrass SR, Martinez-Jaurrieta MD, Ramos-Arroyo MA, Bickham J, Ramos JS, Marshall F, Shoulson I, Rey GJ, Feigin A, Arnheim N, Acevedo-Cruz A, Acosta L, Alvir J, Fischbeck K, Thompson LM, Young A, Dure L, O'Brien CJ, Paulsen J, Brickman A, Krch D, Peery S, Hogarth P, Higgins DS, Landwehrmeyer B. Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset. Proc Natl Acad Sci U S A. 2004 Mar 09; 101(10):3498-503. PMID: 14993615.
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    20. Qin J, Richardson LL, Jasin M, Handel MA, Arnheim N. Mouse strains with an active H2-Ea meiotic recombination hot spot exhibit increased levels of H2-Ea-specific DNA breaks in testicular germ cells. Mol Cell Biol. 2004 Feb; 24(4):1655-66. PMID: 14749381.
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    21. Brohede J, Arnheim N, Ellegren H. Single-molecule analysis of the hypermutable tetranucleotide repeat locus D21S1245 through sperm genotyping: a heterogeneous pattern of mutation but no clear male age effect. Mol Biol Evol. 2004 Jan; 21(1):58-64. PMID: 14530459.
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    22. Yoon SR, Dubeau L, de Young M, Wexler NS, Arnheim N. Huntington disease expansion mutations in humans can occur before meiosis is completed. Proc Natl Acad Sci U S A. 2003 Jul 22; 100(15):8834-8. PMID: 12857955.
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    23. Arnheim N, Calabrese P, Nordborg M. Hot and cold spots of recombination in the human genome: the reason we should find them and how this can be achieved. Am J Hum Genet. 2003 Jul; 73(1):5-16. PMID: 12772086.
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    24. Nenguke T, Aladjem MI, Gusella JF, Wexler NS, Arnheim N. Candidate DNA replication initiation regions at human trinucleotide repeat disease loci. Hum Mol Genet. 2003 May 01; 12(9):1021-8. PMID: 12700170.
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    25. Shinde D, Lai Y, Sun F, Arnheim N. Taq DNA polymerase slippage mutation rates measured by PCR and quasi-likelihood analysis: (CA/GT)n and (A/T)n microsatellites. Nucleic Acids Res. 2003 Feb 01; 31(3):974-80. PMID: 12560493.
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    26. Lai Y, Shinde D, Arnheim N, Sun F. The mutation process of microsatellites during the polymerase chain reaction. J Comput Biol. 2003; 10(2):143-55. PMID: 12804088.
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    27. Tiemann-Boege I, Navidi W, Grewal R, Cohn D, Eskenazi B, Wyrobek AJ, Arnheim N. The observed human sperm mutation frequency cannot explain the achondroplasia paternal age effect. Proc Natl Acad Sci U S A. 2002 Nov 12; 99(23):14952-7. PMID: 12397172.
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    28. Lien S, Szyda J, Leeflang EP, Hubert R, Zhang L, Schmitt K, Arnheim N. Single-sperm typing. Curr Protoc Hum Genet. 2002 May; Chapter 1:Unit 1.6. PMID: 18428321.
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    29. Qin J, Baker S, Te Riele H, Liskay RM, Arnheim N. Evidence for the lack of mismatch-repair directed antirecombination during mouse meiosis. J Hered. 2002 May-Jun; 93(3):201-5. PMID: 12195036.
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    30. Pathak S, Choi SK, Arnheim N, Thompson ME. Hydroxylated quantum dots as luminescent probes for in situ hybridization. J Am Chem Soc. 2001 May 02; 123(17):4103-4. PMID: 11457171.
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    31. Han LL, Keller MP, Navidi W, Chance PF, Arnheim N. Unequal exchange at the Charcot-Marie-Tooth disease type 1A recombination hot-spot is not elevated above the genome average rate. Hum Mol Genet. 2000 Jul 22; 9(12):1881-9. PMID: 10915777.
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    32. Grewal RP, Cancel G, Leeflang EP, Dürr A, McPeek MS, Draghinas D, Yao X, Stevanin G, Alnot MO, Brice A, Arnheim N. French Machado-Joseph disease patients do not exhibit gametic segregation distortion: a sperm typing analysis. Hum Mol Genet. 1999 Sep; 8(9):1779-84. PMID: 10441343.
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    33. Fan F, Liu C, Tavaré S, Arnheim N. Polymorphisms in the human DNA repair gene XPF. Mutat Res. 1999 Aug; 406(2-4):115-20. PMID: 10479728.
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    34. Yao X, Buermeyer AB, Narayanan L, Tran D, Baker SM, Prolla TA, Glazer PM, Liskay RM, Arnheim N. Different mutator phenotypes in Mlh1- versus Pms2-deficient mice. Proc Natl Acad Sci U S A. 1999 Jun 08; 96(12):6850-5. PMID: 10359802.
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    35. Leeflang EP, Tavaré S, Marjoram P, Neal CO, Srinidhi J, MacFarlane H, MacDonald ME, Gusella JF, de Young M, Wexler NS, Arnheim N. Analysis of germline mutation spectra at the Huntington's disease locus supports a mitotic mutation mechanism. Hum Mol Genet. 1999 Feb; 8(2):173-83. PMID: 9931325.
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    36. Korobova O, Lane PW, Perry J, Palmer S, Ashworth A, Davisson MT, Arnheim N. Patchy fur, a mouse coat mutation associated with X-Y nondisjunction, maps to the pseudoautosomal boundary region. Genomics. 1998 Dec 15; 54(3):556-9. PMID: 9878259.
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    37. Grewal RP, Leeflang EP, Zhang L, Arnheim N. The mutation properties of spinal and bulbar muscular atrophy disease alleles. Neurogenetics. 1998 Aug; 1(4):249-52. PMID: 10732798.
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    38. Xu G, Sze SH, Liu CP, Pevzner PA, Arnheim N. Gene hunting without sequencing genomic clones: finding exon boundaries in cDNAs. Genomics. 1998 Jan 15; 47(2):171-9. PMID: 9479489.
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    39. Arnheim N, Shibata D. DNA mismatch repair in mammals: role in disease and meiosis. Curr Opin Genet Dev. 1997 Jun; 7(3):364-70. PMID: 9229112.
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    40. Fan F, Liu CP, Korobova O, Heyting C, Offenberg HH, Trump G, Arnheim N. cDNA cloning and characterization of Npap60: a novel rat nuclear pore-associated protein with an unusual subcellular localization during male germ cell differentiation. Genomics. 1997 Mar 15; 40(3):444-53. PMID: 9073512.
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    41. Yu J, Lazzeroni L, Qin J, Huang MM, Navidi W, Erlich H, Arnheim N. Individual variation in recombination among human males. Am J Hum Genet. 1996 Dec; 59(6):1186-92. PMID: 8940263.
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    42. Soong NW, Dang MH, Hinton DR, Arnheim N. Mitochondrial DNA deletions are rare in the free radical-rich retinal environment. Neurobiol Aging. 1996 Nov-Dec; 17(6):827-31. PMID: 9363792.
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    43. Leeflang EP, McPeek MS, Arnheim N. Analysis of meiotic segregation, using single-sperm typing: meiotic drive at the myotonic dystrophy locus. Am J Hum Genet. 1996 Oct; 59(4):896-904. PMID: 8808606.
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    44. Petruska J, Arnheim N, Goodman MF. Stability of intrastrand hairpin structures formed by the CAG/CTG class of DNA triplet repeats associated with neurological diseases. Nucleic Acids Res. 1996 Jun 01; 24(11):1992-8. PMID: 8668527.
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    45. Soong NW, Arnheim N. Detection and quantification of mitochondrial DNA deletions. Methods Enzymol. 1996; 264:421-31. PMID: 8965714.
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    46. Sun F, Arnheim N, Waterman MS. Whole genome amplification of single cells: mathematical analysis of PEP and tagged PCR. Nucleic Acids Res. 1995 Aug 11; 23(15):3034-40. PMID: 7659528.
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    47. Zhang L, Fischbeck KH, Arnheim N. CAG repeat length variation in sperm from a patient with Kennedy's disease. Hum Mol Genet. 1995 Feb; 4(2):303-5. PMID: 7757084.
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    48. Leeflang EP, Arnheim N. A novel repeat structure at the myotonic dystrophy locus in a 37 repeat allele with unexpectedly high stability. Hum Mol Genet. 1995 Jan; 4(1):135-6. PMID: 7711725.
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    49. Huang MM, Erlich HA, Goodman MF, Arnheim N. Analysis of mutational changes at the HLA locus in single human sperm. Hum Mutat. 1995; 6(4):303-10. PMID: 8680404.
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    50. Ling X, Arnheim N. Cloning and identification of the pig ribosomal gene promoter. Gene. 1994 Dec 15; 150(2):375-9. PMID: 7821810.
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    51. Schmitt K, Lazzeroni LC, Foote S, Vollrath D, Fisher EM, Goradia TM, Lange K, Page DC, Arnheim N. Multipoint linkage map of the human pseudoautosomal region, based on single-sperm typing: do double crossovers occur during male meiosis? Am J Hum Genet. 1994 Sep; 55(3):423-30. PMID: 8079986.
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    52. Zhang L, Leeflang EP, Yu J, Arnheim N. Studying human mutations by sperm typing: instability of CAG trinucleotide repeats in the human androgen receptor gene. Nat Genet. 1994 Aug; 7(4):531-5. PMID: 7951325.
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    53. Hubert R, MacDonald M, Gusella J, Arnheim N. High resolution localization of recombination hot spots using sperm typing. Nat Genet. 1994 Jul; 7(3):420-4. PMID: 7920662.
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    54. Schmitt K, Arnheim N. Genetic recombination analysis using sperm typing. Genet Eng (N Y). 1994; 16:157-65. PMID: 7765195.
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    55. Schmitt K, Vollrath D, Foote S, Fisher EM, Page DC, Arnheim N. Four PCR-based polymorphisms in the pseudoautosomal region of the human X and Y chromosomes. Hum Mol Genet. 1993 Nov; 2(11):1978. PMID: 8281166.
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    56. Ling X, Shenkar R, Sakai D, Arnheim N. The mouse Eb meiotic recombination hotspot contains a tissue-specific transcriptional enhancer. Immunogenetics. 1993; 37(5):331-6. PMID: 8428766.
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    57. Soong NW, Hinton DR, Cortopassi G, Arnheim N. Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain. Nat Genet. 1992 Dec; 2(4):318-23. PMID: 1303287.
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    58. Hubert R, Weber JL, Schmitt K, Zhang L, Arnheim N. A new source of polymorphic DNA markers for sperm typing: analysis of microsatellite repeats in single cells. Am J Hum Genet. 1992 Nov; 51(5):985-91. PMID: 1415267.
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    59. Huang MM, Arnheim N, Goodman MF. Extension of base mispairs by Taq DNA polymerase: implications for single nucleotide discrimination in PCR. Nucleic Acids Res. 1992 Sep 11; 20(17):4567-73. PMID: 1408758.
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    60. Cortopassi GA, Arnheim N. Using the polymerase chain reaction to estimate mutation frequencies and rates in human cells. Mutat Res. 1992 Sep; 277(3):239-49. PMID: 1381052.
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    61. Arnheim N, Cortopassi G. Deleterious mitochondrial DNA mutations accumulate in aging human tissues. Mutat Res. 1992 Sep; 275(3-6):157-67. PMID: 1383758.
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    62. Cortopassi GA, Shibata D, Soong NW, Arnheim N. A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. Proc Natl Acad Sci U S A. 1992 Aug 15; 89(16):7370-4. PMID: 1502147.
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    63. Zhang L, Cui X, Schmitt K, Hubert R, Navidi W, Arnheim N. Whole genome amplification from a single cell: implications for genetic analysis. Proc Natl Acad Sci U S A. 1992 Jul 01; 89(13):5847-51. PMID: 1631067.
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    64. Cui X, Gerwin J, Navidi W, Li H, Kuehn M, Arnheim N. Gene-centromere linkage mapping by PCR analysis of individual oocytes. Genomics. 1992 Jul; 13(3):713-7. PMID: 1639398.
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    65. Hubert R, Stanton VP, Aburatani H, Warren J, Li H, Housman DE, Arnheim N. Sperm typing allows accurate measurement of the recombination fraction between D3S2 and D3S3 on the short arm of human chromosome 3. Genomics. 1992 Apr; 12(4):683-7. PMID: 1349296.
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    66. Creighton S, Huang MM, Cai H, Arnheim N, Goodman MF. Base mispair extension kinetics. Binding of avian myeloblastosis reverse transcriptase to matched and mismatched base pair termini. J Biol Chem. 1992 Feb 05; 267(4):2633-9. PMID: 1370828.
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    67. Navidi W, Arnheim N, Waterman MS. A multiple-tubes approach for accurate genotyping of very small DNA samples by using PCR: statistical considerations. Am J Hum Genet. 1992 Feb; 50(2):347-59. PMID: 1734715.
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    68. Arnheim N, Erlich H. Polymerase chain reaction strategy. Annu Rev Biochem. 1992; 61:131-56. PMID: 1379788.
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    69. Navidi W, Arnheim N. Using PCR in preimplantation genetic disease diagnosis. Hum Reprod. 1991 Jul; 6(6):836-49. PMID: 1757524.
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    70. Li HH, Cui XF, Arnheim N. Eliminating primers from completed polymerase chain reactions with exonuclease VII. Nucleic Acids Res. 1991 Jun 11; 19(11):3139-41. PMID: 2057368.
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    71. Shenkar R, Shen MH, Arnheim N. DNase I-hypersensitive sites and transcription factor-binding motifs within the mouse E beta meiotic recombination hot spot. Mol Cell Biol. 1991 Apr; 11(4):1813-9. PMID: 1900917.
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    72. Arnheim N, Li H, Cui X. Genetic mapping by single sperm typing. Anim Genet. 1991; 22(2):105-15. PMID: 1892244.
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    73. Cortopassi GA, Arnheim N. Detection of a specific mitochondrial DNA deletion in tissues of older humans. Nucleic Acids Res. 1990 Dec 11; 18(23):6927-33. PMID: 2263455.
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    74. Arnheim N, Li HH, Cui XF. PCR analysis of DNA sequences in single cells: single sperm gene mapping and genetic disease diagnosis. Genomics. 1990 Nov; 8(3):415-9. PMID: 2286370.
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    75. Li H, Cui X, Arnheim N. Direct electrophoretic detection of the allelic state of single DNA molecules in human sperm by using the polymerase chain reaction. Proc Natl Acad Sci U S A. 1990 Jun; 87(12):4580-4. PMID: 1972276.
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    76. Arnheim N. The possible role of Z DNA in chromosomal translocations. Cancer Cells. 1990 Apr; 2(4):121-2. PMID: 2390418.
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    77. Shibata D, Almoguera C, Forrester K, Dunitz J, Martin SE, Cosgrove MM, Perucho M, Arnheim N. Detection of c-K-ras mutations in fine needle aspirates from human pancreatic adenocarcinomas. Cancer Res. 1990 Feb 15; 50(4):1279-83. PMID: 2404591.
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    78. Arnheim N. The polymerase chain reaction. Genet Eng (N Y). 1990; 12:115-37. PMID: 1369998.
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    79. Li HH, Cui XF, Arnheim N. Analysis of DNA sequences in individual gametes: application to human genetic mapping. Prog Clin Biol Res. 1990; 340C:207-11. PMID: 2199979.
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    80. Cui XF, Li HH, Goradia TM, Lange K, Kazazian HH, Galas D, Arnheim N. Single-sperm typing: determination of genetic distance between the G gamma-globin and parathyroid hormone loci by using the polymerase chain reaction and allele-specific oligomers. Proc Natl Acad Sci U S A. 1989 Dec; 86(23):9389-93. PMID: 2574460.
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    81. Shibata D, Brynes RK, Nathwani B, Kwok S, Sninsky J, Arnheim N. Human immunodeficiency viral DNA is readily found in lymph node biopsies from seropositive individuals. Analysis of fixed tissue using the polymerase chain reaction. Am J Pathol. 1989 Oct; 135(4):697-702. PMID: 2679114.
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    82. Hemsley A, Arnheim N, Toney MD, Cortopassi G, Galas DJ. A simple method for site-directed mutagenesis using the polymerase chain reaction. Nucleic Acids Res. 1989 Aug 25; 17(16):6545-51. PMID: 2674899.
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    83. Kiyabu MT, Shibata D, Arnheim N, Martin WJ, Fitzgibbons PL. Detection of human papillomavirus in formalin-fixed, invasive squamous carcinomas using the polymerase chain reaction. Am J Surg Pathol. 1989 Mar; 13(3):221-4. PMID: 2537583.
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    84. Shibata D, Cosgrove M, Arnheim N, Martin WJ, Martin SE. Detection of human papillomavirus DNA in fine-needle aspirations of metastatic squamous-cell carcinoma of the uterine cervix using the polymerase chain reaction. Diagn Cytopathol. 1989; 5(1):40-3. PMID: 2541988.
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    85. Shibata D, Martin WJ, Appleman MD, Causey DM, Leedom JM, Arnheim N. Detection of cytomegalovirus DNA in peripheral blood of patients infected with human immunodeficiency virus. J Infect Dis. 1988 Dec; 158(6):1185-92. PMID: 2848898.
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    86. Shibata D, Fu YS, Gupta JW, Shah KV, Arnheim N, Martin WJ. Detection of human papillomavirus in normal and dysplastic tissue by the polymerase chain reaction. Lab Invest. 1988 Oct; 59(4):555-9. PMID: 2845193.
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    87. Li HH, Gyllensten UB, Cui XF, Saiki RK, Erlich HA, Arnheim N. Amplification and analysis of DNA sequences in single human sperm and diploid cells. Nature. 1988 Sep 29; 335(6189):414-7. PMID: 3419517.
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    88. Shibata D, Martin WJ, Arnheim N. Analysis of DNA sequences in forty-year-old paraffin-embedded thin-tissue sections: a bridge between molecular biology and classical histology. Cancer Res. 1988 Aug 15; 48(16):4564-6. PMID: 2840197.
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    89. Shibata DK, Arnheim N, Martin WJ. Detection of human papilloma virus in paraffin-embedded tissue using the polymerase chain reaction. J Exp Med. 1988 Jan 01; 167(1):225-30. PMID: 2826637.
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    90. Arnheim N. New technologies for studying human genetic variation. Basic Life Sci. 1988; 43:37-44. PMID: 2896495.
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    91. Arnheim N, Cocks GT, Wilson AC. Molecular size of hagfish muscle lactate dehydrogenase. Science. 1967 Aug 04; 157(3788):568-9. PMID: 6028922.
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    92. Arnheim N. The regional effects of two mutants in Drosophila analyzed by means of mosaics. Genetics. 1967 Jun; 56(2):253-63. PMID: 6040494.
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    93. Tokunaga C, Arnheim N. Age dependence of the locations of x-ray induced somatic crossing over in Drosophila. Genetics. 1966 Jul; 54(1):267-76. PMID: 5961482.
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