Norman Arnheim, PhD

Title(s)Distinguished Professor of Biological Sciences and Biochemistry and Molecular Biology, and Ester Dornsife Chair in Biological Sciences
SchoolKeck School of Medicine of Usc
AddressRRI 319C
University Park Campus
Los Angeles CA 90089-2910
Phone+1 213 740 7675
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    Collapse Research 
    Collapse Research Activities and Funding
    MITOCHONDRIAL DNA MUTATION AND AGING
    NIH R01AG011492May 1, 1993 - Apr 30, 1996
    Role: Principal Investigator
    GENETIC AND MOLECULAR STUDIES OF RDNA
    NIH R01GM042942Jul 1, 1989 - Jun 30, 1992
    Role: Principal Investigator
    GENETIC AND MOLECULAR STUDIES OF RDNA
    NIH R01HG000328Jul 1, 1989 - Jun 30, 1992
    Role: Principal Investigator
    Genetic Analysis Using Sperm Typing
    NIH R01GM036745Sep 1, 1985 - Aug 31, 2019
    Role: Principal Investigator
    GENETICS STUDIES USING SPERM TYPING
    NIH R37GM036745Sep 1, 1985 - Mar 31, 2002
    Role: Principal Investigator
    MOLECULAR MECHANISMS OF DNA TRANSPOSITION
    NIH R01AI019036Apr 1, 1982 - Dec 31, 1996
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Estimating Exceptionally Rare Germline and Somatic Mutation Frequencies via Next Generation Sequencing. PLoS One. 2016; 11(6):e0158340. Eboreime J, Choi SK, Yoon SR, Arnheim N, Calabrese P. PMID: 27341568; PMCID: PMC4920415.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    2. Germline Stem Cell Competition, Mutation Hot Spots, Genetic Disorders, and Older Fathers. Annu Rev Genomics Hum Genet. 2016 08 31; 17:219-43. Arnheim N, Calabrese P. PMID: 27070266; PMCID: PMC5007215.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    3. New evidence for positive selection helps explain the paternal age effect observed in achondroplasia. Hum Mol Genet. 2013 Oct 15; 22(20):4117-26. Shinde DN, Elmer DP, Calabrese P, Boulanger J, Arnheim N, Tiemann-Boege I. PMID: 23740942; PMCID: PMC3781639.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    4. Age-dependent germline mosaicism of the most common noonan syndrome mutation shows the signature of germline selection. Am J Hum Genet. 2013 Jun 06; 92(6):917-26. Yoon SR, Choi SK, Eboreime J, Gelb BD, Calabrese P, Arnheim N. PMID: 23726368; PMCID: PMC3682763.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    5. Positive selection for new disease mutations in the human germline: evidence from the heritable cancer syndrome multiple endocrine neoplasia type 2B. PLoS Genet. 2012; 8(2):e1002420. Choi SK, Yoon SR, Calabrese P, Arnheim N. PMID: 22359510; PMCID: PMC3280958.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    6. Product length, dye choice, and detection chemistry in the bead-emulsion amplification of millions of single DNA molecules in parallel. Anal Chem. 2009 Jul 15; 81(14):5770-6. Tiemann-Boege I, Curtis C, Shinde DN, Goodman DB, Tavaré S, Arnheim N. PMID: 19601653; PMCID: PMC2733210.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    7. The ups and downs of mutation frequencies during aging can account for the Apert syndrome paternal age effect. PLoS Genet. 2009 Jul; 5(7):e1000558. Yoon SR, Qin J, Glaser RL, Jabs EW, Wexler NS, Sokol R, Arnheim N, Calabrese P. PMID: 19593369; PMCID: PMC2700275.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    8. Understanding what determines the frequency and pattern of human germline mutations. Nat Rev Genet. 2009 Jul; 10(7):478-88. Arnheim N, Calabrese P. PMID: 19488047; PMCID: PMC2744436.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    9. Detection of meiotic DNA breaks in mouse testicular germ cells. Methods Mol Biol. 2009; 557:165-81. Qin J, Subramanian J, Arnheim N. PMID: 19799182.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    10. A germ-line-selective advantage rather than an increased mutation rate can explain some unexpectedly common human disease mutations. Proc Natl Acad Sci U S A. 2008 Jul 22; 105(29):10143-8. Choi SK, Yoon SR, Calabrese P, Arnheim N. PMID: 18632557; PMCID: PMC2474563.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    11. The molecular anatomy of spontaneous germline mutations in human testes. PLoS Biol. 2007 Sep; 5(9):e224. Qin J, Calabrese P, Tiemann-Boege I, Shinde DN, Yoon SR, Gelfand D, Bauer K, Arnheim N. PMID: 17760502; PMCID: PMC1951783.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    12. Triplet repeat mutation length gains correlate with cell-type specific vulnerability in Huntington disease brain. Hum Mol Genet. 2007 May 15; 16(10):1133-42. Shelbourne PF, Keller-McGandy C, Bi WL, Yoon SR, Dubeau L, Veitch NJ, Vonsattel JP, Wexler NS, US-Venezuela Collaborative Research Group, Arnheim N, Augood SJ. PMID: 17409200.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimalsCells
    13. Mammalian meiotic recombination hot spots. Annu Rev Genet. 2007; 41:369-99. Arnheim N, Calabrese P, Tiemann-Boege I. PMID: 18076329.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    14. Combining sperm typing and linkage disequilibrium analyses reveals differences in selective pressures or recombination rates across human populations. Genetics. 2007 Feb; 175(2):795-804. Clark VJ, Ptak SE, Tiemann I, Qian Y, Coop G, Stone AC, Przeworski M, Arnheim N, Di Rienzo A. PMID: 17151245; PMCID: PMC1800598.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    15. High-resolution recombination patterns in a region of human chromosome 21 measured by sperm typing. PLoS Genet. 2006 May; 2(5):e70. Tiemann-Boege I, Calabrese P, Cochran DM, Sokol R, Arnheim N. PMID: 16680198; PMCID: PMC1456319.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    16. Differential contributions of mammalian Rad54 paralogs to recombination, DNA damage repair, and meiosis. Mol Cell Biol. 2006 Feb; 26(3):976-89. Wesoly J, Agarwal S, Sigurdsson S, Bussen W, Van Komen S, Qin J, van Steeg H, van Benthem J, Wassenaar E, Baarends WM, Ghazvini M, Tafel AA, Heath H, Galjart N, Essers J, Grootegoed JA, Arnheim N, Bezzubova O, Buerstedde JM, Sung P, Kanaar R. PMID: 16428451; PMCID: PMC1347043.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    17. Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse. Cancer Res. 2005 Oct 01; 65(19):8662-70. Chen PC, Dudley S, Hagen W, Dizon D, Paxton L, Reichow D, Yoon SR, Yang K, Arnheim N, Liskay RM, Lipkin SM. PMID: 16204034.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    18. Genetic instability induced by overexpression of DNA ligase I in budding yeast. Genetics. 2005 Oct; 171(2):427-41. Subramanian J, Vijayakumar S, Tomkinson AE, Arnheim N. PMID: 15965249; PMCID: PMC1456761.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    19. Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset. Proc Natl Acad Sci U S A. 2004 Mar 09; 101(10):3498-503. Wexler NS, Lorimer J, Porter J, Gomez F, Moskowitz C, Shackell E, Marder K, Penchaszadeh G, Roberts SA, Gayán J, Brocklebank D, Cherny SS, Cardon LR, Gray J, Dlouhy SR, Wiktorski S, Hodes ME, Conneally PM, Penney JB, Gusella J, Cha JH, Irizarry M, Rosas D, Hersch S, Hollingsworth Z, MacDonald M, Young AB, Andresen JM, Housman DE, De Young MM, Bonilla E, Stillings T, Negrette A, Snodgrass SR, Martinez-Jaurrieta MD, Ramos-Arroyo MA, Bickham J, Ramos JS, Marshall F, Shoulson I, Rey GJ, Feigin A, Arnheim N, Acevedo-Cruz A, Acosta L, Alvir J, Fischbeck K, Thompson LM, Young A, Dure L, O'Brien CJ, Paulsen J, Brickman A, Krch D, Peery S, Hogarth P, Higgins DS, Landwehrmeyer B, U.S.-Venezuela Collaborative Research Project. PMID: 14993615; PMCID: PMC373491.
      View in: PubMed   Mentions: 231     Fields:    Translation:HumansCells
    20. Mouse strains with an active H2-Ea meiotic recombination hot spot exhibit increased levels of H2-Ea-specific DNA breaks in testicular germ cells. Mol Cell Biol. 2004 Feb; 24(4):1655-66. Qin J, Richardson LL, Jasin M, Handel MA, Arnheim N. PMID: 14749381; PMCID: PMC344187.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    21. Single-molecule analysis of the hypermutable tetranucleotide repeat locus D21S1245 through sperm genotyping: a heterogeneous pattern of mutation but no clear male age effect. Mol Biol Evol. 2004 Jan; 21(1):58-64. Brohede J, Arnheim N, Ellegren H. PMID: 14530459.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    22. Huntington disease expansion mutations in humans can occur before meiosis is completed. Proc Natl Acad Sci U S A. 2003 Jul 22; 100(15):8834-8. Yoon SR, Dubeau L, de Young M, Wexler NS, Arnheim N. PMID: 12857955; PMCID: PMC166399.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    23. Hot and cold spots of recombination in the human genome: the reason we should find them and how this can be achieved. Am J Hum Genet. 2003 Jul; 73(1):5-16. Arnheim N, Calabrese P, Nordborg M. PMID: 12772086; PMCID: PMC1180590.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    24. Candidate DNA replication initiation regions at human trinucleotide repeat disease loci. Hum Mol Genet. 2003 May 01; 12(9):1021-8. Nenguke T, Aladjem MI, Gusella JF, Wexler NS, Arnheim N, Venezuela HD Project. PMID: 12700170.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    25. Taq DNA polymerase slippage mutation rates measured by PCR and quasi-likelihood analysis: (CA/GT)n and (A/T)n microsatellites. Nucleic Acids Res. 2003 Feb 01; 31(3):974-80. Shinde D, Lai Y, Sun F, Arnheim N. PMID: 12560493; PMCID: PMC149199.
      View in: PubMed   Mentions: 74     Fields:    Translation:Cells
    26. The mutation process of microsatellites during the polymerase chain reaction. J Comput Biol. 2003; 10(2):143-55. Lai Y, Shinde D, Arnheim N, Sun F. PMID: 12804088.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    27. The observed human sperm mutation frequency cannot explain the achondroplasia paternal age effect. Proc Natl Acad Sci U S A. 2002 Nov 12; 99(23):14952-7. Tiemann-Boege I, Navidi W, Grewal R, Cohn D, Eskenazi B, Wyrobek AJ, Arnheim N. PMID: 12397172; PMCID: PMC137526.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    28. Single-sperm typing. Curr Protoc Hum Genet. 2002 May; Chapter 1:Unit 1.6. Lien S, Szyda J, Leeflang EP, Hubert R, Zhang L, Schmitt K, Arnheim N. PMID: 18428321.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    29. Evidence for the lack of mismatch-repair directed antirecombination during mouse meiosis. J Hered. 2002 May-Jun; 93(3):201-5. Qin J, Baker S, Te Riele H, Liskay RM, Arnheim N. PMID: 12195036.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    30. Hydroxylated quantum dots as luminescent probes for in situ hybridization. J Am Chem Soc. 2001 May 02; 123(17):4103-4. Pathak S, Choi SK, Arnheim N, Thompson ME. PMID: 11457171.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    31. Unequal exchange at the Charcot-Marie-Tooth disease type 1A recombination hot-spot is not elevated above the genome average rate. Hum Mol Genet. 2000 Jul 22; 9(12):1881-9. Han LL, Keller MP, Navidi W, Chance PF, Arnheim N. PMID: 10915777.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    32. French Machado-Joseph disease patients do not exhibit gametic segregation distortion: a sperm typing analysis. Hum Mol Genet. 1999 Sep; 8(9):1779-84. Grewal RP, Cancel G, Leeflang EP, Dürr A, McPeek MS, Draghinas D, Yao X, Stevanin G, Alnot MO, Brice A, Arnheim N. PMID: 10441343.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    33. Polymorphisms in the human DNA repair gene XPF. Mutat Res. 1999 Aug; 406(2-4):115-20. Fan F, Liu C, Tavaré S, Arnheim N. PMID: 10479728.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    34. Different mutator phenotypes in Mlh1- versus Pms2-deficient mice. Proc Natl Acad Sci U S A. 1999 Jun 08; 96(12):6850-5. Yao X, Buermeyer AB, Narayanan L, Tran D, Baker SM, Prolla TA, Glazer PM, Liskay RM, Arnheim N. PMID: 10359802; PMCID: PMC22005.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    35. Analysis of germline mutation spectra at the Huntington's disease locus supports a mitotic mutation mechanism. Hum Mol Genet. 1999 Feb; 8(2):173-83. Leeflang EP, Tavaré S, Marjoram P, Neal CO, Srinidhi J, MacFarlane H, MacDonald ME, Gusella JF, de Young M, Wexler NS, Arnheim N. PMID: 9931325.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    36. Patchy fur, a mouse coat mutation associated with X-Y nondisjunction, maps to the pseudoautosomal boundary region. Genomics. 1998 Dec 15; 54(3):556-9. Korobova O, Lane PW, Perry J, Palmer S, Ashworth A, Davisson MT, Arnheim N. PMID: 9878259.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    37. The mutation properties of spinal and bulbar muscular atrophy disease alleles. Neurogenetics. 1998 Aug; 1(4):249-52. Grewal RP, Leeflang EP, Zhang L, Arnheim N. PMID: 10732798.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    38. Gene hunting without sequencing genomic clones: finding exon boundaries in cDNAs. Genomics. 1998 Jan 15; 47(2):171-9. Xu G, Sze SH, Liu CP, Pevzner PA, Arnheim N. PMID: 9479489.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    39. DNA mismatch repair in mammals: role in disease and meiosis. Curr Opin Genet Dev. 1997 Jun; 7(3):364-70. Arnheim N, Shibata D. PMID: 9229112.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    40. cDNA cloning and characterization of Npap60: a novel rat nuclear pore-associated protein with an unusual subcellular localization during male germ cell differentiation. Genomics. 1997 Mar 15; 40(3):444-53. Fan F, Liu CP, Korobova O, Heyting C, Offenberg HH, Trump G, Arnheim N. PMID: 9073512.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    41. Individual variation in recombination among human males. Am J Hum Genet. 1996 Dec; 59(6):1186-92. Yu J, Lazzeroni L, Qin J, Huang MM, Navidi W, Erlich H, Arnheim N. PMID: 8940263; PMCID: PMC1914855.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    42. Mitochondrial DNA deletions are rare in the free radical-rich retinal environment. Neurobiol Aging. 1996 Nov-Dec; 17(6):827-31. Soong NW, Dang MH, Hinton DR, Arnheim N. PMID: 9363792.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    43. Analysis of meiotic segregation, using single-sperm typing: meiotic drive at the myotonic dystrophy locus. Am J Hum Genet. 1996 Oct; 59(4):896-904. Leeflang EP, McPeek MS, Arnheim N. PMID: 8808606; PMCID: PMC1914809.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    44. Stability of intrastrand hairpin structures formed by the CAG/CTG class of DNA triplet repeats associated with neurological diseases. Nucleic Acids Res. 1996 Jun 01; 24(11):1992-8. Petruska J, Arnheim N, Goodman MF. PMID: 8668527; PMCID: PMC145917.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    45. Detection and quantification of mitochondrial DNA deletions. Methods Enzymol. 1996; 264:421-31. Soong NW, Arnheim N. PMID: 8965714.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    46. Whole genome amplification of single cells: mathematical analysis of PEP and tagged PCR. Nucleic Acids Res. 1995 Aug 11; 23(15):3034-40. Sun F, Arnheim N, Waterman MS. PMID: 7659528; PMCID: PMC307146.
      View in: PubMed   Mentions: 8     Fields:    
    47. CAG repeat length variation in sperm from a patient with Kennedy's disease. Hum Mol Genet. 1995 Feb; 4(2):303-5. Zhang L, Fischbeck KH, Arnheim N. PMID: 7757084.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    48. A novel repeat structure at the myotonic dystrophy locus in a 37 repeat allele with unexpectedly high stability. Hum Mol Genet. 1995 Jan; 4(1):135-6. Leeflang EP, Arnheim N. PMID: 7711725.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    49. Analysis of mutational changes at the HLA locus in single human sperm. Hum Mutat. 1995; 6(4):303-10. Huang MM, Erlich HA, Goodman MF, Arnheim N. PMID: 8680404.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    50. Cloning and identification of the pig ribosomal gene promoter. Gene. 1994 Dec 15; 150(2):375-9. Ling X, Arnheim N. PMID: 7821810.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    51. Multipoint linkage map of the human pseudoautosomal region, based on single-sperm typing: do double crossovers occur during male meiosis? Am J Hum Genet. 1994 Sep; 55(3):423-30. Schmitt K, Lazzeroni LC, Foote S, Vollrath D, Fisher EM, Goradia TM, Lange K, Page DC, Arnheim N. PMID: 8079986; PMCID: PMC1918414.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    52. Studying human mutations by sperm typing: instability of CAG trinucleotide repeats in the human androgen receptor gene. Nat Genet. 1994 Aug; 7(4):531-5. Zhang L, Leeflang EP, Yu J, Arnheim N. PMID: 7951325.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    53. High resolution localization of recombination hot spots using sperm typing. Nat Genet. 1994 Jul; 7(3):420-4. Hubert R, MacDonald M, Gusella J, Arnheim N. PMID: 7920662.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    54. Genetic recombination analysis using sperm typing. Genet Eng (N Y). 1994; 16:157-65. Schmitt K, Arnheim N. PMID: 7765195.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    55. Four PCR-based polymorphisms in the pseudoautosomal region of the human X and Y chromosomes. Hum Mol Genet. 1993 Nov; 2(11):1978. Schmitt K, Vollrath D, Foote S, Fisher EM, Page DC, Arnheim N. PMID: 8281166.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    56. The mouse Eb meiotic recombination hotspot contains a tissue-specific transcriptional enhancer. Immunogenetics. 1993; 37(5):331-6. Ling X, Shenkar R, Sakai D, Arnheim N. PMID: 8428766.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    57. Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain. Nat Genet. 1992 Dec; 2(4):318-23. Soong NW, Hinton DR, Cortopassi G, Arnheim N. PMID: 1303287.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansCells
    58. A new source of polymorphic DNA markers for sperm typing: analysis of microsatellite repeats in single cells. Am J Hum Genet. 1992 Nov; 51(5):985-91. Hubert R, Weber JL, Schmitt K, Zhang L, Arnheim N. PMID: 1415267; PMCID: PMC1682826.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    59. Extension of base mispairs by Taq DNA polymerase: implications for single nucleotide discrimination in PCR. Nucleic Acids Res. 1992 Sep 11; 20(17):4567-73. Huang MM, Arnheim N, Goodman MF. PMID: 1408758; PMCID: PMC334186.
      View in: PubMed   Mentions: 93     Fields:    Translation:Cells
    60. Using the polymerase chain reaction to estimate mutation frequencies and rates in human cells. Mutat Res. 1992 Sep; 277(3):239-49. Cortopassi GA, Arnheim N. PMID: 1381052.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    61. Deleterious mitochondrial DNA mutations accumulate in aging human tissues. Mutat Res. 1992 Sep; 275(3-6):157-67. Arnheim N, Cortopassi G. PMID: 1383758.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    62. A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. Proc Natl Acad Sci U S A. 1992 Aug 15; 89(16):7370-4. Cortopassi GA, Shibata D, Soong NW, Arnheim N. PMID: 1502147; PMCID: PMC49711.
      View in: PubMed   Mentions: 132     Fields:    Translation:Humans
    63. Whole genome amplification from a single cell: implications for genetic analysis. Proc Natl Acad Sci U S A. 1992 Jul 01; 89(13):5847-51. Zhang L, Cui X, Schmitt K, Hubert R, Navidi W, Arnheim N. PMID: 1631067; PMCID: PMC49394.
      View in: PubMed   Mentions: 239     Fields:    Translation:HumansCells
    64. Gene-centromere linkage mapping by PCR analysis of individual oocytes. Genomics. 1992 Jul; 13(3):713-7. Cui X, Gerwin J, Navidi W, Li H, Kuehn M, Arnheim N. PMID: 1639398.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    65. Sperm typing allows accurate measurement of the recombination fraction between D3S2 and D3S3 on the short arm of human chromosome 3. Genomics. 1992 Apr; 12(4):683-7. Hubert R, Stanton VP, Aburatani H, Warren J, Li H, Housman DE, Arnheim N. PMID: 1349296.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    66. Base mispair extension kinetics. Binding of avian myeloblastosis reverse transcriptase to matched and mismatched base pair termini. J Biol Chem. 1992 Feb 05; 267(4):2633-9. Creighton S, Huang MM, Cai H, Arnheim N, Goodman MF. PMID: 1370828.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    67. A multiple-tubes approach for accurate genotyping of very small DNA samples by using PCR: statistical considerations. Am J Hum Genet. 1992 Feb; 50(2):347-59. Navidi W, Arnheim N, Waterman MS. PMID: 1734715; PMCID: PMC1682471.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    68. Polymerase chain reaction strategy. Annu Rev Biochem. 1992; 61:131-56. Arnheim N, Erlich H. PMID: 1379788.
      View in: PubMed   Mentions: 25     Fields:    Translation:Cells
    69. Using PCR in preimplantation genetic disease diagnosis. Hum Reprod. 1991 Jul; 6(6):836-49. Navidi W, Arnheim N. PMID: 1757524.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    70. Eliminating primers from completed polymerase chain reactions with exonuclease VII. Nucleic Acids Res. 1991 Jun 11; 19(11):3139-41. Li HH, Cui XF, Arnheim N. PMID: 2057368; PMCID: PMC328282.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    71. DNase I-hypersensitive sites and transcription factor-binding motifs within the mouse E beta meiotic recombination hot spot. Mol Cell Biol. 1991 Apr; 11(4):1813-9. Shenkar R, Shen MH, Arnheim N. PMID: 1900917; PMCID: PMC359851.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    72. Genetic mapping by single sperm typing. Anim Genet. 1991; 22(2):105-15. Arnheim N, Li H, Cui X. PMID: 1892244.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    73. Detection of a specific mitochondrial DNA deletion in tissues of older humans. Nucleic Acids Res. 1990 Dec 11; 18(23):6927-33. Cortopassi GA, Arnheim N. PMID: 2263455; PMCID: PMC332752.
      View in: PubMed   Mentions: 167     Fields:    Translation:HumansCells
    74. PCR analysis of DNA sequences in single cells: single sperm gene mapping and genetic disease diagnosis. Genomics. 1990 Nov; 8(3):415-9. Arnheim N, Li HH, Cui XF. PMID: 2286370.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    75. Direct electrophoretic detection of the allelic state of single DNA molecules in human sperm by using the polymerase chain reaction. Proc Natl Acad Sci U S A. 1990 Jun; 87(12):4580-4. Li H, Cui X, Arnheim N. PMID: 1972276; PMCID: PMC54160.
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    76. The possible role of Z DNA in chromosomal translocations. Cancer Cells. 1990 Apr; 2(4):121-2. Arnheim N. PMID: 2390418.
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    77. Detection of c-K-ras mutations in fine needle aspirates from human pancreatic adenocarcinomas. Cancer Res. 1990 Feb 15; 50(4):1279-83. Shibata D, Almoguera C, Forrester K, Dunitz J, Martin SE, Cosgrove MM, Perucho M, Arnheim N. PMID: 2404591.
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    78. The polymerase chain reaction. Genet Eng (N Y). 1990; 12:115-37. Arnheim N. PMID: 1369998.
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    79. Analysis of DNA sequences in individual gametes: application to human genetic mapping. Prog Clin Biol Res. 1990; 340C:207-11. Li HH, Cui XF, Arnheim N. PMID: 2199979.
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    80. Single-sperm typing: determination of genetic distance between the G gamma-globin and parathyroid hormone loci by using the polymerase chain reaction and allele-specific oligomers. Proc Natl Acad Sci U S A. 1989 Dec; 86(23):9389-93. Cui XF, Li HH, Goradia TM, Lange K, Kazazian HH, Galas D, Arnheim N. PMID: 2574460; PMCID: PMC298501.
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    81. Human immunodeficiency viral DNA is readily found in lymph node biopsies from seropositive individuals. Analysis of fixed tissue using the polymerase chain reaction. Am J Pathol. 1989 Oct; 135(4):697-702. Shibata D, Brynes RK, Nathwani B, Kwok S, Sninsky J, Arnheim N. PMID: 2679114; PMCID: PMC1880034.
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    82. A simple method for site-directed mutagenesis using the polymerase chain reaction. Nucleic Acids Res. 1989 Aug 25; 17(16):6545-51. Hemsley A, Arnheim N, Toney MD, Cortopassi G, Galas DJ. PMID: 2674899; PMCID: PMC318348.
      View in: PubMed   Mentions: 206     Fields:    Translation:Cells
    83. Detection of human papillomavirus in formalin-fixed, invasive squamous carcinomas using the polymerase chain reaction. Am J Surg Pathol. 1989 Mar; 13(3):221-4. Kiyabu MT, Shibata D, Arnheim N, Martin WJ, Fitzgibbons PL. PMID: 2537583.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    84. Detection of human papillomavirus DNA in fine-needle aspirations of metastatic squamous-cell carcinoma of the uterine cervix using the polymerase chain reaction. Diagn Cytopathol. 1989; 5(1):40-3. Shibata D, Cosgrove M, Arnheim N, Martin WJ, Martin SE. PMID: 2541988.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    85. Detection of cytomegalovirus DNA in peripheral blood of patients infected with human immunodeficiency virus. J Infect Dis. 1988 Dec; 158(6):1185-92. Shibata D, Martin WJ, Appleman MD, Causey DM, Leedom JM, Arnheim N. PMID: 2848898.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansCells
    86. Detection of human papillomavirus in normal and dysplastic tissue by the polymerase chain reaction. Lab Invest. 1988 Oct; 59(4):555-9. Shibata D, Fu YS, Gupta JW, Shah KV, Arnheim N, Martin WJ. PMID: 2845193.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    87. Amplification and analysis of DNA sequences in single human sperm and diploid cells. Nature. 1988 Sep 29; 335(6189):414-7. Li HH, Gyllensten UB, Cui XF, Saiki RK, Erlich HA, Arnheim N. PMID: 3419517.
      View in: PubMed   Mentions: 153     Fields:    Translation:HumansCells
    88. Analysis of DNA sequences in forty-year-old paraffin-embedded thin-tissue sections: a bridge between molecular biology and classical histology. Cancer Res. 1988 Aug 15; 48(16):4564-6. Shibata D, Martin WJ, Arnheim N. PMID: 2840197.
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    89. Detection of human papilloma virus in paraffin-embedded tissue using the polymerase chain reaction. J Exp Med. 1988 Jan 01; 167(1):225-30. Shibata DK, Arnheim N, Martin WJ. PMID: 2826637; PMCID: PMC2188813.
      View in: PubMed   Mentions: 175     Fields:    Translation:Cells
    90. New technologies for studying human genetic variation. Basic Life Sci. 1988; 43:37-44. Arnheim N. PMID: 2896495.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    91. Molecular size of hagfish muscle lactate dehydrogenase. Science. 1967 Aug 04; 157(3788):568-9. Arnheim N, Cocks GT, Wilson AC. PMID: 6028922.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    92. The regional effects of two mutants in Drosophila analyzed by means of mosaics. Genetics. 1967 Jun; 56(2):253-63. Arnheim N. PMID: 6040494; PMCID: PMC1211501.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    93. Age dependence of the locations of x-ray induced somatic crossing over in Drosophila. Genetics. 1966 Jul; 54(1):267-76. Tokunaga C, Arnheim N. PMID: 5961482; PMCID: PMC1211107.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
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