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    Nikolaos Skandalis, PhD

    TitleAssociate Professor of Research Medicine
    SchoolKeck School of Medicine of USC
    DepartmentMedicine
    Address2020 ZONAL AVE.
    Off Campus
    Los Angeles California 90033
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      Collapse Overview 
      Collapse Overview
      Plants are colonized by commensal, symbiotic, plant-associated and pathogenic bacteria. Several prokaryotic species antagonize for this niche by using antibiotics and enhancing their competence. Moreover, they have evolved to interact with the plant host. Dr. Skandalis's main research interest is the control of plant pathogenic bacteria with the lowest environmental impact. He translates basic research of the triple interaction among plants, bacterial pathogens and bacterial biological control agents (BCA) to outcomes that would support disease management strategies under field conditions. His recruitment at the USC Keck School of Medicine provides a unique opportunity to combine his specialties in plant-microbe interactions with substantial knowledge of established USC faculty in antibiotic resistance, to study the effect of modern agriculture to transmission of antibiotic resistance in the food chain. He is also involved in multidisciplinary projects that led to the development of environmental friendly plant protection products that have either a direct effect against pathogenic bacteria (silver or copper nanoparticles, natural extracts, dual function fertilizers) or elicit plant defenses (organic pesticides, bacterial elicitors).


      Collapse Biography 
      Collapse Education and Training
      Imperial College, London, EnglandPhD & Diploma of Imperial College (DIC)2005Biology
      Imperial College at Wye, Ashford, EnglandMSc1998Biological Crop Protection
      Aristotle University of Thessaloniki, Thessaloniki, GreeceBSc-MSc1996Plant Science
      Collapse Awards and Honors
      Institute of Molecular Biology and Biotechnology2001  - 2005Fellowship for post-graduate studies
      Novartis Pharmaceuticals UK Ltd1998Novartis award for best MSc thesis project
      Greek Fellowship Foundtain (IKY)1997  - 2001Fellowship for Post-graduate studies

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Skandalis N, Dimopoulou A, Georgopoulou A, Gallios N, Papadopoulos D, Tsipas D, Theologidis I, Michailidis N, Chatzinikolaidou M. The Effect of Silver Nanoparticles Size, Produced Using Plant Extract from Arbutus unedo, on Their Antibacterial Efficacy. Nanomaterials (Basel). 2017 Jul 10; 7(7). PMID: 28698511.
        View in: PubMed
      2. Skandalis N, Dimopoulou A., Beri D., Tzima A., Malandraki I., Theologidis I., Bitivanos S., Varveri C., Klitsinaris T., Vassilakos N. . Effect of pyraclostrobin application on viral and bacterial diseases of tomato. Plant Disease. 2017; 7(100):1321-1330.
      3. Katis N., Velisariou D., Goumas D., Karaoglanidis G., Lagopodi A., Maliogka V., Panopoulos N.J., Sinapidou E., Skandalis N, Hatziloukas E. . Plant Pathology. 2016; 884.
      4. Papadakis G, Skandalis N, Dimopoulou A, Glynos P, Gizeli E. Bacteria Murmur: Application of an Acoustic Biosensor for Plant Pathogen Detection. PLoS One. 2015; 10(7):e0132773. PMID: 26177507; PMCID: PMC4503732.
      5. Skandalis N, Sarris P.F., Panopoulos N.J. Targeting injectisomes of virulence: Benefits of thirty years of research on bacterial secretion systems, to crop protection. Hellenic Plant Protection Journal. 2012; (5):31-47.
      6. Sarris P.F., Trantas E.A., Skandalis N, Tampakaki A.P., Kapanidou M., Kokkinidis M., Panopoulos N.J. . Phytobacterial Type VI Secretion System - Gene Distribution, Phylogeny, Structure and Biological Functions. Plant Pathology. 2011.
      7. Sarris PF, Skandalis N, Kokkinidis M, Panopoulos NJ. In silico analysis reveals multiple putative type VI secretion systems and effector proteins in Pseudomonas syringae pathovars. Mol Plant Pathol. 2010 Nov; 11(6):795-804. PMID: 21091602.
        View in: PubMed
      8. Tampakaki N., Skandalis N, Sarris P.F., Charova S., Gazi T., Kokkinidis M., Panopoulos N.J. . Playing the HRP: Evolution of Our Understanding of HRP genes. Ann Rev Phytopathology. 2010; (48):347-370.
      9. Moschou PN, Sarris PF, Skandalis N, Andriopoulou AH, Paschalidis KA, Panopoulos NJ, Roubelakis-Angelakis KA. Engineered polyamine catabolism preinduces tolerance of tobacco to bacteria and oomycetes. Plant Physiol. 2009 Apr; 149(4):1970-81. PMID: 19218362; PMCID: PMC2663742.
      10. Sarris P., Abdelhalim M., Kitner M., Skandalis N, Panopoulos N.J, Doulis A., Lebeda A. . Molecular polymorphism between populations of Pseudoperonospora cubensis from Greece and the Czech Republic and their phytopathological and phylogenetic implications. . Plant Pathology. 2009; (58):933-943.
      11. Skandalis N, Spanou Z., Badreddine I., Dumas B., Bottin A. Evolution of the Oomycete Chitin Synthase genes. Phytopathol. Mediterr. 2009; (48):334.
      12. Badreddine I, Lafitte C, Heux L, Skandalis N, Spanou Z, Martinez Y, Esquerré-Tugayé MT, Bulone V, Dumas B, Bottin A. Cell wall chitosaccharides are essential components and exposed patterns of the phytopathogenic oomycete Aphanomyces euteiches. Eukaryot Cell. 2008 Nov; 7(11):1980-93. PMID: 18806214; PMCID: PMC2583540.
      13. Skandalis N, Spanou Z., Mavrakis T., Saloustrou K., Xenos C., Theophilou S., Piceno Y., Kouvarakis A., Andersen G., Stefanou E., Panopoulos N.J. Bacterial Species isolated from untreated olive mill wastewaters reduce its toxic load and produce high added value antioxidants. FEBS J. 2008; (275):363-364.