Neil I. Segil, PhD

TitleProfessor of Research Stem Cell & Regenerative Medicine
InstitutionUniversity of Southern California
DepartmentStem Cell Biology & Regenerative Medicine
AddressBCC 506 1425 San Pablo Street
University Park Campus
Los Angeles CA 90033
Phone+1 323 442 1549
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    Collapse Overview 

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    Epigenetic mechanisms underlying the failure of hair cell regeneration in mammals
    NIH/NIDCD R01DC015829Jul 1, 2018 - Jun 30, 2023
    Role: Principal Investigator
    Lineage reprogramming for hearing loss: development of drug screening and gene therapy approaches
    NIH/NIDCD R01DC015530Jul 1, 2016 - Jun 30, 2021
    Role: Principal Investigator
    Training in Hearing and Communication Neuroscience
    NIH/NIDCD T32DC009975Jul 1, 2009 - Jun 30, 2019
    Role: Co-Principal Investigator
    The cell cycle in ototoxin induced hair cell death.
    NIH/NIDCD R01DC007173Jul 1, 2005 - Jun 30, 2010
    Role: Principal Investigator
    Marking hair cell progenitors with BAC transgenics
    NIH/NIDCD R21DC006139Apr 1, 2003 - Mar 31, 2006
    Role: Principal Investigator
    Cell cycle in development and regeneration of the inner ear
    NIH/NIDCD R01DC004189Aug 1, 1999 - Nov 30, 2014
    Role: Principal Investigator
    NIH/NIDCD R03DC003767May 1, 1998 - Apr 30, 2002
    Role: Principal Investigator
    NIH/NIGMS F32GM013752Jan 9, 1991
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Gnedeva K, Hudspeth AJ, Segil N. Three-dimensional Organotypic Cultures of Vestibular and Auditory Sensory Organs. J Vis Exp. 2018 06 01; (136). PMID: 29912206.
      View in: PubMed
    2. Semerci F, Choi WT, Bajic A, Thakkar A, Encinas JM, Depreux F, Segil N, Groves AK, Maletic-Savatic M. Lunatic fringe-mediated Notch signaling regulates adult hippocampal neural stem cell maintenance. Elife. 2017 07 12; 6. PMID: 28699891.
      View in: PubMed
    3. Teng CS, Yen HY, Barske L, Smith B, Llamas J, Segil N, Go J, Sanchez-Lara PA, Maxson RE, Crump JG. Requirement for Jagged1-Notch2 signaling in patterning the bones of the mouse and human middle ear. Sci Rep. 2017 May 31; 7(1):2497. PMID: 28566723.
      View in: PubMed
    4. Basch ML, Brown RM, Jen HI, Semerci F, Depreux F, Edlund RK, Zhang H, Norton CR, Gridley T, Cole SE, Doetzlhofer A, Maletic-Savatic M, Segil N, Groves AK. Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates. Elife. 2016 12 14; 5. PMID: 27966429.
      View in: PubMed
    5. Stojanova ZP, Kwan T, Segil N. Epigenetic regulation of Atoh1 guides hair cell development in the mammalian cochlea. Development. 2016 05 01; 143(9):1632. PMID: 27143757; PMCID: PMC4986168.
    6. Rainey RN, Ng SY, Llamas J, van der Horst GT, Segil N. Mutations in Cockayne Syndrome-Associated Genes (Csa and Csb) Predispose to Cisplatin-Induced Hearing Loss in Mice. J Neurosci. 2016 04 27; 36(17):4758-70. PMID: 27122034; PMCID: PMC4846672 [Available on 10/27/16].
    7. Abdolazimi Y, Stojanova Z, Segil N. Selection of cell fate in the organ of Corti involves the integration of Hes/Hey signaling at the Atoh1 promoter. Development. 2016 Mar 01; 143(5):841-50. PMID: 26932672; PMCID: PMC4813338 [Available on 03/01/17].
    8. Stojanova ZP, Kwan T, Segil N. Epigenetic regulation of Atoh1 guides hair cell development in the mammalian cochlea. Development. 2015 Oct 15; 142(20):3529-36. PMID: 26487780; PMCID: PMC4631768 [Available on 10/15/16].
    9. Tao L, Segil N. Early transcriptional response to aminoglycoside antibiotic suggests alternate pathways leading to apoptosis in sensory hair cells in the mouse inner ear. Front Cell Neurosci. 2015; 9:190. PMID: 26052268; PMCID: PMC4439550.
    10. Nagtegaal AP, Rainey RN, van der Pluijm I, Brandt RM, van der Horst GT, Borst JG, Segil N. Cockayne syndrome group B (Csb) and group a (Csa) deficiencies predispose to hearing loss and cochlear hair cell degeneration in mice. J Neurosci. 2015 Mar 11; 35(10):4280-6. PMID: 25762674; PMCID: PMC4355199.
    11. Worman HJ, Segil N. Nucleocytoplasmic connections and deafness. J Clin Invest. 2013 Feb; 123(2):553-5. PMID: 23348730; PMCID: PMC3561842.
    12. White PM, Stone JS, Groves AK, Segil N. EGFR signaling is required for regenerative proliferation in the cochlea: conservation in birds and mammals. Dev Biol. 2012 Mar 01; 363(1):191-200. PMID: 22230616; PMCID: PMC3288574.
    13. Basch ML, Ohyama T, Segil N, Groves AK. Canonical Notch signaling is not necessary for prosensory induction in the mouse cochlea: insights from a conditional mutant of RBPjkappa. J Neurosci. 2011 Jun 01; 31(22):8046-58. PMID: 21632926; PMCID: PMC3112354.
    14. Ohyama T, Basch ML, Mishina Y, Lyons KM, Segil N, Groves AK. BMP signaling is necessary for patterning the sensory and nonsensory regions of the developing mammalian cochlea. J Neurosci. 2010 Nov 10; 30(45):15044-51. PMID: 21068310; PMCID: PMC3074492.
    15. Kwan T, White PM, Segil N. Development and regeneration of the inner ear. Ann N Y Acad Sci. 2009 Jul; 1170:28-33. PMID: 19686102.
      View in: PubMed
    16. Doetzlhofer A, Basch ML, Ohyama T, Gessler M, Groves AK, Segil N. Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti. Dev Cell. 2009 Jan; 16(1):58-69. PMID: 19154718; PMCID: PMC2696015.
    17. Jayasena CS, Ohyama T, Segil N, Groves AK. Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode. Development. 2008 Jul; 135(13):2251-61. PMID: 18495817; PMCID: PMC2575054.
    18. Raft S, Koundakjian EJ, Quinones H, Jayasena CS, Goodrich LV, Johnson JE, Segil N, Groves AK. Cross-regulation of Ngn1 and Math1 coordinates the production of neurons and sensory hair cells during inner ear development. Development. 2007 Dec; 134(24):4405-15. PMID: 18039969.
      View in: PubMed
    19. Laine H, Doetzlhofer A, Mantela J, Ylikoski J, Laiho M, Roussel MF, Segil N, Pirvola U. p19(Ink4d) and p21(Cip1) collaborate to maintain the postmitotic state of auditory hair cells, their codeletion leading to DNA damage and p53-mediated apoptosis. J Neurosci. 2007 Feb 07; 27(6):1434-44. PMID: 17287518.
      View in: PubMed
    20. White PM, Doetzlhofer A, Lee YS, Groves AK, Segil N. Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells. Nature. 2006 Jun 22; 441(7096):984-7. PMID: 16791196.
      View in: PubMed
    21. Lee YS, Liu F, Segil N. A morphogenetic wave of p27Kip1 transcription directs cell cycle exit during organ of Corti development. Development. 2006 Aug; 133(15):2817-26. PMID: 16790479.
      View in: PubMed
    22. Doetzlhofer A, White P, Lee YS, Groves A, Segil N. Prospective identification and purification of hair cell and supporting cell progenitors from the embryonic cochlea. Brain Res. 2006 May 26; 1091(1):282-8. PMID: 16616734.
      View in: PubMed
    23. Wang J, Hamblet NS, Mark S, Dickinson ME, Brinkman BC, Segil N, Fraser SE, Chen P, Wallingford JB, Wynshaw-Boris A. Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation. Development. 2006 May; 133(9):1767-78. PMID: 16571627; PMCID: PMC4158842.
    24. Radde-Gallwitz K, Pan L, Gan L, Lin X, Segil N, Chen P. Expression of Islet1 marks the sensory and neuronal lineages in the mammalian inner ear. J Comp Neurol. 2004 Sep 27; 477(4):412-21. PMID: 15329890; PMCID: PMC4158841.
    25. Doetzlhofer A, White PM, Johnson JE, Segil N, Groves AK. In vitro growth and differentiation of mammalian sensory hair cell progenitors: a requirement for EGF and periotic mesenchyme. Dev Biol. 2004 Aug 15; 272(2):432-47. PMID: 15282159.
      View in: PubMed
    26. Lumpkin EA, Collisson T, Parab P, Omer-Abdalla A, Haeberle H, Chen P, Doetzlhofer A, White P, Groves A, Segil N, Johnson JE. Math1-driven GFP expression in the developing nervous system of transgenic mice. Gene Expr Patterns. 2003 Aug; 3(4):389-95. PMID: 12915300.
      View in: PubMed
    27. Chen P, Zindy F, Abdala C, Liu F, Li X, Roussel MF, Segil N. Progressive hearing loss in mice lacking the cyclin-dependent kinase inhibitor Ink4d. Nat Cell Biol. 2003 May; 5(5):422-6. PMID: 12717441.
      View in: PubMed
    28. Chen P, Johnson JE, Zoghbi HY, Segil N. The role of Math1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determination. Development. 2002 May; 129(10):2495-505. PMID: 11973280.
      View in: PubMed
    29. Morishita H, Makishima T, Kaneko C, Lee YS, Segil N, Takahashi K, Kuraoka A, Nakagawa T, Nabekura J, Nakayama K, Nakayama KI. Deafness due to degeneration of cochlear neurons in caspase-3-deficient mice. Biochem Biophys Res Commun. 2001 Jun 01; 284(1):142-9. PMID: 11374883.
      View in: PubMed
    30. Chen P, Segil N. p27(Kip1) links cell proliferation to morphogenesis in the developing organ of Corti. Development. 1999 Apr; 126(8):1581-90. PMID: 10079221.
      View in: PubMed
    31. Courvalin JC, Segil N, Blobel G, Worman HJ. The lamin B receptor of the inner nuclear membrane undergoes mitosis-specific phosphorylation and is a substrate for p34cdc2-type protein kinase. J Biol Chem. 1992 Sep 25; 267(27):19035-8. PMID: 1326541.
      View in: PubMed
    32. Roberts SB, Segil N, Heintz N. Differential phosphorylation of the transcription factor Oct1 during the cell cycle. Science. 1991 Aug 30; 253(5023):1022-6. PMID: 1887216.
      View in: PubMed
    33. Trenkner E, Smith D, Segil N. Is cerebellar granule cell migration regulated by an internal clock? J Neurosci. 1984 Nov; 4(11):2850-5. PMID: 6502207.
      View in: PubMed