Michael R Stallcup, PhD

Title(s)Professor of Biochemistry & Molecular Medicine
SchoolKeck School of Medicine of USC
Phone+1 323 865 3852
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    Collapse Biography 
    Collapse Education and Training
    Yale University, New Haven, CTB.A.1969Chemistry
    University of California, Berkeley, Berkeley CAPh.D.1974Biochemistry
    Collapse Awards and Honors
    Yale University1967Phi Beta Kappa
    Yale University1969Graduated Magna Cum Laude
    National Science Foundation1969  - 1972Graduate Traineeship
    American Cancer Society1974  - 1975Postdoctoral Fellowship
    National Institutes of Health1977  - 1979National Research Service Award
    National Institutes of Health1983  - 1988Research Career Development Award
    Dept of Pathology, University of Southern California1988  - 2003R.S. Cleland Teaching Award (6 times)
    Molecular Endocrinology1990  - 1994Editorial Board
    American Cancer Society1997  - 1998Chair, Tumor Biochemistry and Endocrinology Study Section
    Molecular Endocrinology1999  - 2002Editorial Board
    Keck School of Medicine, University of Southern California2001Outstanding Gaduate Student Teaching Award
    Journal of Biological Chemistry2004  - 2009Editorial Board
    Dept of Pathology, University of Southern California2006Distinguished Service Award
    National Institutes of Health, NIDDK2008  - 2017MERIT Award
    American Association for the Advancement of Science2009Fellow
    University of Southern California2010USC Mellon Award for Excellence in Faculty Mentoring
    National Institutes of Health2014  - 2016Chair, Molecular and Cellular Endocrinology Study Section

    Collapse Overview 
    Collapse Overview
    Michael R. Stallcup, Ph.D. received his B.A. at Yale University, his Ph.D. at the University of California at Berkeley, and did his postdoctoral training at the University of California at San Francisco. He began his career on the faculty at the University of South Carolina, joining USC in 1985 where he is a Professor in the Department of Biochemistry and Molecular Biology. He serves as co-leader with Dr. Peggy Farnham of the Epigenetics and Regulation Program. In his studies on transcriptional regulation by steroid hormone receptions, he is one of the leading researchers in discovering and characterizing transcriptional coregulators. Specifically his research focuses on coregulators that help steroid receptors alter chromatin structure and recruit RNA polymerase to the target genes that are regulated by steroid hormones and their receptors. His lab discovered the first histone methyltransferase and was the first to demonstrate a role for histone methylation in transcriptional regulation. His lab is currently exploring the molecular mechanisms of coregulator action and the physiological roles of specific coregulators in cancer and inflammatory diseases.

    Current projects are examining the role of the homologous coregulators G9a (EHMT2) and GLP (EHMT1), which methylate histones and other proteins, in glucocorticoid-regulated transcription. His lab discovered that G9a and GLP can serve as coactivators for some genes and corepressors for other genes. They showed that the coactivator activity is controlled by adjacent methylation and phosphorylation modifications: self-methylation is required for coactivator activity, while phosphorylation by Aurora kinase B inhibits coactivator activity. His lab showed that G9a and GLP are required for glucocorticoid-induced expression of specific genes that lead to cell death in leukemia cells. Glucocorticoids are used as a standard part of therapy for leukemia and other hematologic malignancies, but many patients become resistant to this therapy. Based on the above molecular mechanism, Dr. Stallcup's lab has shown that Aurora kinase B inhibitors and demethylase inhibitors can enhance the coactivator activity of G9a, enhance glucocorticoid activation of the genes that promote cell death, and enhance glucocorticoid-induced cell death in leukemia cells, including cells from leukemia patients that are resistant to the standard therapy. Studies in mouse models are currently underway with an aim to generate preclinical data to support clinical trials conducted by clinical collaborators.

    In other projects, Dr. Stallcup's lab is also exploring the roles of G9a and GLP and their post-translational modification in other physiological systems, including energy metabolism in liver, fat, and muscle tissues.

    Research Interests: Regulation of transcription by steroid hormones; molecular and physiological roles of transcriptional coregulators

    Disease Models: cancer, inflammatory diseases

    Collapse Research 
    Collapse Research Activities and Funding
    Training in Cellular, Biochemical and Molecular Sciences
    NIH/NIGMS T32GM067587Jul 1, 2003 - Jun 30, 2014
    Role: Principal Investigator
    Protein methyltransferases as transcriptional coregulators
    NIH/NIDDK R37DK055274Jan 15, 1999 - Dec 31, 2017
    Role: Principal Investigator
    Protein methyltransferases as transcription coactivators
    NIH/NIDDK R01DK055274Jan 15, 1999 - Dec 31, 2007
    Role: Principal Investigator
    Role of Coregulators in Steroid Hormone-Regulated Transcription
    NIH/NIDDK R01DK043093Jul 1, 1990 - Jan 31, 2020
    Role: Principal Investigator
    NIH/NIDDK R01DK038921Aug 1, 1987 - Jul 31, 1991
    Role: Principal Investigator
    NIH/NIGMS R01GM036317Sep 1, 1985 - Mar 31, 1989
    Role: Principal Investigator
    NIH/NCI K04CA001149Sep 1, 1985 - Jun 30, 1988
    Role: Principal Investigator
    NIH/NCI K04CA000897Jul 1, 1983 - Aug 31, 1985
    Role: Principal Investigator
    NIH/NIGMS R01GM028298Jul 1, 1980 - Aug 31, 1985
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News
    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Poulard C, Kim HN, Fang M, Kruth K, Gagnieux C, Gerke DS, Bhojwani D, Kim YM, Kampmann M, Stallcup MR, Pufall MA. Relapse-associated AURKB blunts the glucocorticoid sensitivity of B cell acute lymphoblastic leukemia. Proc Natl Acad Sci U S A. 2019 Feb 07. PMID: 30733284.
      View in: PubMed
    2. Poulard C, Baulu E, Lee BH, Pufall MA, Stallcup MR. Increasing G9a automethylation sensitizes B acute lymphoblastic leukemia cells to glucocorticoid-induced death. Cell Death Dis. 2018 Oct 10; 9(10):1038. PMID: 30305606.
      View in: PubMed
    3. Jin ML, Kim YW, Jin HL, Kang H, Lee EK, Stallcup MR, Jeong KW. Aberrant expression of SETD1A promotes survival and migration of estrogen receptor a-positive breast cancer cells. Int J Cancer. 2018 Dec 01; 143(11):2871-2883. PMID: 30191958.
      View in: PubMed
    4. Lee BH, Stallcup MR. Different chromatin and DNA sequence characteristics define glucocorticoid receptor binding sites that are blocked or not blocked by coregulator Hic-5. PLoS One. 2018; 13(5):e0196965. PMID: 29738565.
      View in: PubMed
    5. Poulard C, Bittencourt D, Wu DY, Hu Y, Gerke DS, Stallcup MR. A post-translational modification switch controls coactivator function of histone methyltransferases G9a and GLP. EMBO Rep. 2017 08; 18(8):1442-1459. PMID: 28615290.
      View in: PubMed
    6. Lee BH, Stallcup MR. Glucocorticoid receptor binding to chromatin is selectively controlled by the coregulator Hic-5 and chromatin remodeling enzymes. J Biol Chem. 2017 06 02; 292(22):9320-9334. PMID: 28381557.
      View in: PubMed
    7. Wu DY, Bittencourt D, Stallcup MR, Siegmund KD. Identifying differential transcription factor binding in ChIP-seq. Front Genet. 2015; 6:169. PMID: 25972895; PMCID: PMC4413818.
    8. Chodankar R, Wu DY, Gerke DS, Stallcup MR. Selective coregulator function and restriction of steroid receptor chromatin occupancy by Hic-5. Mol Endocrinol. 2015 May; 29(5):716-29. PMID: 25763609; PMCID: PMC4415210.
    9. Wu DY, Ou CY, Chodankar R, Siegmund KD, Stallcup MR. Distinct, genome-wide, gene-specific selectivity patterns of four glucocorticoid receptor coregulators. Nucl Recept Signal. 2014; 12:e002. PMID: 25422592.
      View in: PubMed
    10. Bittencourt D, Lee BH, Gao L, Gerke DS, Stallcup MR. Role of distinct surfaces of the G9a ankyrin repeat domain in histone and DNA methylation during embryonic stem cell self-renewal and differentiation. Epigenetics Chromatin. 2014; 7:27. PMID: 25478012; PMCID: PMC4255711.
    11. Schiller BJ, Chodankar R, Watson LC, Stallcup MR, Yamamoto KR. Glucocorticoid receptor binds half sites as a monomer and regulates specific target genes. Genome Biol. 2014 Jul 31; 15(7):418. PMID: 25085117; PMCID: PMC4149261.
    12. Ou CY, Chen TC, Lee JV, Wang JC, Stallcup MR. Coregulator cell cycle and apoptosis regulator 1 (CCAR1) positively regulates adipocyte differentiation through the glucocorticoid signaling pathway. J Biol Chem. 2014 Jun 13; 289(24):17078-86. PMID: 24811171; PMCID: PMC4059149.
    13. Chodankar R, Wu DY, Schiller BJ, Yamamoto KR, Stallcup MR. Hic-5 is a transcription coregulator that acts before and/or after glucocorticoid receptor genome occupancy in a gene-selective manner. Proc Natl Acad Sci U S A. 2014 Mar 18; 111(11):4007-12. PMID: 24591583; PMCID: PMC3964041.
    14. Jeong KW, Andreu-Vieyra C, You JS, Jones PA, Stallcup MR. Establishment of active chromatin structure at enhancer elements by mixed-lineage leukemia 1 to initiate estrogen-dependent gene expression. Nucleic Acids Res. 2014 Feb; 42(4):2245-56. PMID: 24288367; PMCID: PMC3936730.
    15. Balasubramaniam S, Comstock CE, Ertel A, Jeong KW, Stallcup MR, Addya S, McCue PA, Ostrander WF, Augello MA, Knudsen KE. Aberrant BAF57 signaling facilitates prometastatic phenotypes. Clin Cancer Res. 2013 May 15; 19(10):2657-67. PMID: 23493350; PMCID: PMC3655134.
    16. Hoang T, Fenne IS, Madsen A, Bozickovic O, Johannessen M, Bergsvåg M, Lien EA, Stallcup MR, Sagen JV, Moens U, Mellgren G. cAMP response element-binding protein interacts with and stimulates the proteasomal degradation of the nuclear receptor coactivator GRIP1. Endocrinology. 2013 Apr; 154(4):1513-27. PMID: 23462962.
      View in: PubMed
    17. Bittencourt D, Wu DY, Jeong KW, Gerke DS, Herviou L, Ianculescu I, Chodankar R, Siegmund KD, Stallcup MR. G9a functions as a molecular scaffold for assembly of transcriptional coactivators on a subset of glucocorticoid receptor target genes. Proc Natl Acad Sci U S A. 2012 Nov 27; 109(48):19673-8. PMID: 23151507; PMCID: PMC3511704.
    18. Purcell DJ, Khalid O, Ou CY, Little GH, Frenkel B, Baniwal SK, Stallcup MR. Recruitment of coregulator G9a by Runx2 for selective enhancement or suppression of transcription. J Cell Biochem. 2012 Jul; 113(7):2406-14. PMID: 22389001; PMCID: PMC3350606.
    19. Won Jeong K, Chodankar R, Purcell DJ, Bittencourt D, Stallcup MR. Gene-specific patterns of coregulator requirements by estrogen receptor-a in breast cancer cells. Mol Endocrinol. 2012 Jun; 26(6):955-66. PMID: 22543272; PMCID: PMC3355545.
    20. Sharma S, Gerke DS, Han HF, Jeong S, Stallcup MR, Jones PA, Liang G. Lysine methyltransferase G9a is not required for DNMT3A/3B anchoring to methylated nucleosomes and maintenance of DNA methylation in somatic cells. Epigenetics Chromatin. 2012 Jan 27; 5(1):3. PMID: 22284370; PMCID: PMC3292817.
    21. Ianculescu I, Wu DY, Siegmund KD, Stallcup MR. Selective roles for cAMP response element-binding protein binding protein and p300 protein as coregulators for androgen-regulated gene expression in advanced prostate cancer cells. J Biol Chem. 2012 Feb 03; 287(6):4000-13. PMID: 22174411; PMCID: PMC3281703.
    22. Jeong KW, Kim K, Situ AJ, Ulmer TS, An W, Stallcup MR. Recognition of enhancer element-specific histone methylation by TIP60 in transcriptional activation. Nat Struct Mol Biol. 2011 Nov 13; 18(12):1358-65. PMID: 22081016; PMCID: PMC3230772.
    23. Purcell DJ, Jeong KW, Bittencourt D, Gerke DS, Stallcup MR. A distinct mechanism for coactivator versus corepressor function by histone methyltransferase G9a in transcriptional regulation. J Biol Chem. 2011 Dec 09; 286(49):41963-71. PMID: 21984853; PMCID: PMC3234941.
    24. Yu EJ, Kim SH, Heo K, Ou CY, Stallcup MR, Kim JH. Reciprocal roles of DBC1 and SIRT1 in regulating estrogen receptor a activity and co-activator synergy. Nucleic Acids Res. 2011 Sep 01; 39(16):6932-43. PMID: 21596782.
      View in: PubMed
    25. Lee YH, Stallcup MR. Roles of protein arginine methylation in DNA damage signaling pathways is CARM1 a life-or-death decision point? Cell Cycle. 2011 May 01; 10(9):1343-4. PMID: 21445011; PMCID: PMC3117038.
    26. Ou CY, LaBonte MJ, Manegold PC, So AY, Ianculescu I, Gerke DS, Yamamoto KR, Ladner RD, Kahn M, Kim JH, Stallcup MR. A coactivator role of CARM1 in the dysregulation of ß-catenin activity in colorectal cancer cell growth and gene expression. Mol Cancer Res. 2011 May; 9(5):660-70. PMID: 21478268; PMCID: PMC3096696.
    27. Lee YH, Bedford MT, Stallcup MR. Regulated recruitment of tumor suppressor BRCA1 to the p21 gene by coactivator methylation. Genes Dev. 2011 Jan 15; 25(2):176-88. PMID: 21245169; PMCID: PMC3022263.
    28. Obianyo O, Causey CP, Osborne TC, Jones JE, Lee YH, Stallcup MR, Thompson PR. A chloroacetamidine-based inactivator of protein arginine methyltransferase 1: design, synthesis, and in vitro and in vivo evaluation. Chembiochem. 2010 Jun 14; 11(9):1219-23. PMID: 20480486; PMCID: PMC3060404.
    29. Jeong KW, Lee YH, Stallcup MR. Recruitment of the SWI/SNF chromatin remodeling complex to steroid hormone-regulated promoters by nuclear receptor coactivator flightless-I. J Biol Chem. 2009 Oct 23; 284(43):29298-309. PMID: 19720835; PMCID: PMC2785560.
    30. Ou CY, Kim JH, Yang CK, Stallcup MR. Requirement of cell cycle and apoptosis regulator 1 for target gene activation by Wnt and beta-catenin and for anchorage-independent growth of human colon carcinoma cells. J Biol Chem. 2009 Jul 31; 284(31):20629-37. PMID: 19520846; PMCID: PMC2742827.
    31. Haiman CA, Garcia RR, Hsu C, Xia L, Ha H, Sheng X, Le Marchand L, Kolonel LN, Henderson BE, Stallcup MR, Greene GL, Press MF. Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort. BMC Cancer. 2009 Jan 30; 9:43. PMID: 19183483; PMCID: PMC2637888.
    32. Lee YH, Stallcup MR. Minireview: protein arginine methylation of nonhistone proteins in transcriptional regulation. Mol Endocrinol. 2009 Apr; 23(4):425-33. PMID: 19164444; PMCID: PMC2667706.
    33. Khalid O, Baniwal SK, Purcell DJ, Leclerc N, Gabet Y, Stallcup MR, Coetzee GA, Frenkel B. Modulation of Runx2 activity by estrogen receptor-alpha: implications for osteoporosis and breast cancer. Endocrinology. 2008 Dec; 149(12):5984-95. PMID: 18755791; PMCID: PMC2613062.
    34. Kim JH, Yang CK, Heo K, Roeder RG, An W, Stallcup MR. CCAR1, a key regulator of mediator complex recruitment to nuclear receptor transcription complexes. Mol Cell. 2008 Aug 22; 31(4):510-9. PMID: 18722177; PMCID: PMC2562329.
    35. Collins RE, Northrop JP, Horton JR, Lee DY, Zhang X, Stallcup MR, Cheng X. The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules. Nat Struct Mol Biol. 2008 Mar; 15(3):245-50. PMID: 18264113.
      View in: PubMed
    36. Yang CK, Kim JH, Ann DK, Stallcup MR. Differential regulation of the two transcriptional activation domains of the coiled-coil coactivator CoCoA by sumoylation. BMC Mol Biol. 2008 Jan 25; 9:12. PMID: 18218142; PMCID: PMC2263068.
    37. Rao M, Casimiro MC, Lisanti MP, D'Amico M, Wang C, Shirley LA, Leader JE, Liu M, Stallcup M, Engel DA, Murphy DJ, Pestell RG. Inhibition of cyclin D1 gene transcription by Brg-1. Cell Cycle. 2008 Mar 01; 7(5):647-55. PMID: 18239461.
      View in: PubMed
    38. Lee DY, Ianculescu I, Purcell D, Zhang X, Cheng X, Stallcup MR. Surface-scanning mutational analysis of protein arginine methyltransferase 1: roles of specific amino acids in methyltransferase substrate specificity, oligomerization, and coactivator function. Mol Endocrinol. 2007 Jun; 21(6):1381-93. PMID: 17426288; PMCID: PMC2075475.
    39. Chen YH, Yang CK, Xia M, Ou CY, Stallcup MR. Role of GAC63 in transcriptional activation mediated by beta-catenin. Nucleic Acids Res. 2007; 35(6):2084-92. PMID: 17344318; PMCID: PMC1874623.
    40. Luo Y, Arita K, Bhatia M, Knuckley B, Lee YH, Stallcup MR, Sato M, Thompson PR. Inhibitors and inactivators of protein arginine deiminase 4: functional and structural characterization. Biochemistry. 2006 Oct 03; 45(39):11727-36. PMID: 17002273.
      View in: PubMed
    41. Lee YH, Stallcup MR. Interplay of Fli-I and FLAP1 for regulation of beta-catenin dependent transcription. Nucleic Acids Res. 2006; 34(18):5052-9. PMID: 16990252; PMCID: PMC1636430.
    42. Yang CK, Kim JH, Stallcup MR. Role of the N-terminal activation domain of the coiled-coil coactivator in mediating transcriptional activation by beta-catenin. Mol Endocrinol. 2006 Dec; 20(12):3251-62. PMID: 16931570; PMCID: PMC1770943.
    43. Kim JH, Yang CK, Stallcup MR. Downstream signaling mechanism of the C-terminal activation domain of transcriptional coactivator CoCoA. Nucleic Acids Res. 2006; 34(9):2736-50. PMID: 16717280; PMCID: PMC1464418.
    44. Chen YH, Beischlag TV, Kim JH, Perdew GH, Stallcup MR. Role of GAC63 in transcriptional activation mediated by the aryl hydrocarbon receptor. J Biol Chem. 2006 May 05; 281(18):12242-7. PMID: 16513642; PMCID: PMC1770942.
    45. Lee DY, Northrop JP, Kuo MH, Stallcup MR. Histone H3 lysine 9 methyltransferase G9a is a transcriptional coactivator for nuclear receptors. J Biol Chem. 2006 Mar 31; 281(13):8476-85. PMID: 16461774; PMCID: PMC1770944.
    46. Luo Y, Knuckley B, Lee YH, Stallcup MR, Thompson PR. A fluoroacetamidine-based inactivator of protein arginine deiminase 4: design, synthesis, and in vitro and in vivo evaluation. J Am Chem Soc. 2006 Feb 01; 128(4):1092-3. PMID: 16433522; PMCID: PMC1850713.
    47. Yang CK, Kim JH, Li H, Stallcup MR. Differential use of functional domains by coiled-coil coactivator in its synergistic coactivator function with beta-catenin or GRIP1. J Biol Chem. 2006 Feb 10; 281(6):3389-97. PMID: 16344550; PMCID: PMC1626527.
    48. Teyssier C, Ou CY, Khetchoumian K, Losson R, Stallcup MR. Transcriptional intermediary factor 1alpha mediates physical interaction and functional synergy between the coactivator-associated arginine methyltransferase 1 and glucocorticoid receptor-interacting protein 1 nuclear receptor coactivators. Mol Endocrinol. 2006 Jun; 20(6):1276-86. PMID: 16322096; PMCID: PMC1626528.
    49. Kim JH, Lee MH, Kim BJ, Kim JH, Han SJ, Kim HY, Stallcup MR. Role of aspartate 351 in transactivation and active conformation of estrogen receptor alpha. J Mol Endocrinol. 2005 Dec; 35(3):449-64. PMID: 16326832.
      View in: PubMed
    50. Stojadinovic O, Brem H, Vouthounis C, Lee B, Fallon J, Stallcup M, Merchant A, Galiano RD, Tomic-Canic M. Molecular pathogenesis of chronic wounds: the role of beta-catenin and c-myc in the inhibition of epithelialization and wound healing. Am J Pathol. 2005 Jul; 167(1):59-69. PMID: 15972952; PMCID: PMC1603435.
    51. Chen YH, Kim JH, Stallcup MR. GAC63, a GRIP1-dependent nuclear receptor coactivator. Mol Cell Biol. 2005 Jul; 25(14):5965-72. PMID: 15988012; PMCID: PMC1168828.
    52. Teyssier C, Ma H, Emter R, Kralli A, Stallcup MR. Activation of nuclear receptor coactivator PGC-1alpha by arginine methylation. Genes Dev. 2005 Jun 15; 19(12):1466-73. PMID: 15964996; PMCID: PMC1151663.
    53. Lee YH, Coonrod SA, Kraus WL, Jelinek MA, Stallcup MR. Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination. Proc Natl Acad Sci U S A. 2005 Mar 08; 102(10):3611-6. PMID: 15731352; PMCID: PMC553305.
    54. Li YJ, Stallcup MR, Lai MM. Hepatitis delta virus antigen is methylated at arginine residues, and methylation regulates subcellular localization and RNA replication. J Virol. 2004 Dec; 78(23):13325-34. PMID: 15542683; PMCID: PMC524986.
    55. Lee DY, Teyssier C, Strahl BD, Stallcup MR. Role of protein methylation in regulation of transcription. Endocr Rev. 2005 Apr; 26(2):147-70. PMID: 15479858.
      View in: PubMed
    56. Kim JH, Stallcup MR. Role of the coiled-coil coactivator (CoCoA) in aryl hydrocarbon receptor-mediated transcription. J Biol Chem. 2004 Nov 26; 279(48):49842-8. PMID: 15383530.
      View in: PubMed
    57. Wang Y, Wysocka J, Sayegh J, Lee YH, Perlin JR, Leonelli L, Sonbuchner LS, McDonald CH, Cook RG, Dou Y, Roeder RG, Clarke S, Stallcup MR, Allis CD, Coonrod SA. Human PAD4 regulates histone arginine methylation levels via demethylimination. Science. 2004 Oct 08; 306(5694):279-83. PMID: 15345777.
      View in: PubMed
    58. Guerrero-Santoro J, Yang L, Stallcup MR, DeFranco DB. Distinct LIM domains of Hic-5/ARA55 are required for nuclear matrix targeting and glucocorticoid receptor binding and coactivation. J Cell Biochem. 2004 Jul 01; 92(4):810-9. PMID: 15211577.
      View in: PubMed
    59. Lee YH, Campbell HD, Stallcup MR. Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activity. Mol Cell Biol. 2004 Mar; 24(5):2103-17. PMID: 14966289; PMCID: PMC350567.
    60. Kim JH, Li H, Stallcup MR. CoCoA, a nuclear receptor coactivator which acts through an N-terminal activation domain of p160 coactivators. Mol Cell. 2003 Dec; 12(6):1537-49. PMID: 14690606.
      View in: PubMed
    61. Li H, Kim JH, Koh SS, Stallcup MR. Synergistic effects of coactivators GRIP1 and beta-catenin on gene activation: cross-talk between androgen receptor and Wnt signaling pathways. J Biol Chem. 2004 Feb 06; 279(6):4212-20. PMID: 14638683.
      View in: PubMed
    62. Stallcup MR, Kim JH, Teyssier C, Lee YH, Ma H, Chen D. The roles of protein-protein interactions and protein methylation in transcriptional activation by nuclear receptors and their coactivators. J Steroid Biochem Mol Biol. 2003 Jun; 85(2-5):139-45. PMID: 12943698.
      View in: PubMed
    63. Ma H, Shang Y, Lee DY, Stallcup MR. Study of nuclear receptor-induced transcription complex assembly and histone modification by chromatin immunoprecipitation assays. Methods Enzymol. 2003; 364:284-96. PMID: 14631851.
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    64. Teyssier C, Chen D, Stallcup MR. Requirement for multiple domains of the protein arginine methyltransferase CARM1 in its transcriptional coactivator function. J Biol Chem. 2002 Nov 29; 277(48):46066-72. PMID: 12351636.
      View in: PubMed
    65. Li H, Park S, Kilburn B, Jelinek MA, Henschen-Edman A, Aswad DW, Stallcup MR, Laird-Offringa IA. Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase. J Biol Chem. 2002 Nov 22; 277(47):44623-30. PMID: 12237300.
      View in: PubMed
    66. Lee YH, Koh SS, Zhang X, Cheng X, Stallcup MR. Synergy among nuclear receptor coactivators: selective requirement for protein methyltransferase and acetyltransferase activities. Mol Cell Biol. 2002 Jun; 22(11):3621-32. PMID: 11997499; PMCID: PMC133819.
    67. Zhou H, Luo MP, Schönthal AH, Pike MC, Stallcup MR, Blumenthal M, Zheng W, Dubeau L. Effect of reproductive hormones on ovarian epithelial tumors: I. Effect on cell cycle activity. Cancer Biol Ther. 2002 May-Jun; 1(3):300-6. PMID: 12432283.
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    68. Koh SS, Li H, Lee YH, Widelitz RB, Chuong CM, Stallcup MR. Synergistic coactivator function by coactivator-associated arginine methyltransferase (CARM) 1 and beta-catenin with two different classes of DNA-binding transcriptional activators. J Biol Chem. 2002 Jul 19; 277(29):26031-5. PMID: 11983685; PMCID: PMC4386649.
    69. Chen SL, Loffler KA, Chen D, Stallcup MR, Muscat GE. The coactivator-associated arginine methyltransferase is necessary for muscle differentiation: CARM1 coactivates myocyte enhancer factor-2. J Biol Chem. 2002 Feb 08; 277(6):4324-33. PMID: 11713257.
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