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    Michael R Stallcup, PhD

    TitleProfessor of Biochemistry & Molecular Medicine
    SchoolKeck School of Medicine of USC
    AddressNOR 6316 1441 Eastlake Avenue
    Health Sciences Campus
    Los Angeles California 90089
    Phone+1 323 865 3852
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      Collapse Overview 
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      Michael R. Stallcup, Ph.D. received his B.A. at Yale University, his Ph.D. at the University of California at Berkeley, and did his postdoctoral training at the University of California at San Francisco. He began his career on the faculty at the University of South Carolina, joining USC in 1985 where he is a Professor in the Department of Biochemistry and Molecular Biology. He serves as co-leader with Dr. Peggy Farnham of the Epigenetics and Regulation Program. In his studies on transcriptional regulation by steroid hormone receptions, he is one of the leading researchers in discovering and characterizing coregulators. Specifically his research focuses on coregulators that help steroid receptors alter chromatin structure and recruit RNA polymerase to the target genes that are regulated by steroid hormones and their receptors. His lab discovered the first histone methyltransferase and was the first to demonstrate a role for histone methylation in transcriptional regulation. His lab is currently exploring the molecular mechanisms of coregulator action and the physiological roles of specific coregulators in cancer and inflammatory diseases.

      Research Interests: Regulation of transcription by steroid hormones; molecular and physiological roles of transcriptional coregulators

      Disease Models: cancer, inflammatory diseases

      Collapse Biography 
      Collapse Education and Training
      Yale University, New Haven, CTB.A.1969Chemistry
      University of California, Berkeley, Berkeley CAPh.D.1974Biochemistry
      Collapse Awards and Honors
      Yale University1967Phi Beta Kappa
      Yale University1969Graduated Magna Cum Laude
      National Science Foundation1969  - 1972Graduate Traineeship
      American Cancer Society1974  - 1975Postdoctoral Fellowship
      National Institutes of Health1977  - 1979National Research Service Award
      National Institutes of Health1983  - 1988Research Career Development Award
      Dept of Pathology, University of Southern California1988  - 2003R.S. Cleland Teaching Award (6 times)
      Molecular Endocrinology1990  - 1994Editorial Board
      American Cancer Society1997  - 1998Chair, Tumor Biochemistry and Endocrinology Study Section
      Molecular Endocrinology1999  - 2002Editorial Board
      Keck School of Medicine, University of Southern California2001Outstanding Gaduate Student Teaching Award
      Journal of Biological Chemistry2004  - 2009Editorial Board
      Dept of Pathology, University of Southern California2006Distinguished Service Award
      National Institutes of Health, NIDDK2008  - 2017MERIT Award
      American Association for the Advancement of Science2009Fellow
      University of Southern California2010USC Mellon Award for Excellence in Faculty Mentoring
      National Institutes of Health2014  - 2016Chair, Molecular and Cellular Endocrinology Study Section

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      Collapse In The News

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Poulard C, Bittencourt D, Wu DY, Hu Y, Gerke DS, Stallcup M. A post-translational modification switch controls coactivator function of histone methyltransferases G9a and GLP. EMBO Rep. 2017 Aug; 18(8):1442-1459. PMID: 28615290.
        View in: PubMed
      2. Lee BH, Stallcup M. Glucocorticoid receptor binding to chromatin is selectively controlled by the coregulator Hic-5 and chromatin remodeling enzymes. J Biol Chem. 2017 Jun 02; 292(22):9320-9334. PMID: 28381557.
        View in: PubMed
      3. Wu DY, Bittencourt D, Stallcup M, Siegmund KD. Identifying differential transcription factor binding in ChIP-seq. Front Genet. 2015; 6:169. PMID: 25972895; PMCID: PMC4413818.
      4. Chodankar R, Wu DY, Gerke DS, Stallcup M. Selective coregulator function and restriction of steroid receptor chromatin occupancy by Hic-5. Mol Endocrinol. 2015 May; 29(5):716-29. PMID: 25763609; PMCID: PMC4415210.
      5. Wu DY, Ou CY, Chodankar R, Siegmund KD, Stallcup M. Distinct, genome-wide, gene-specific selectivity patterns of four glucocorticoid receptor coregulators. Nucl Recept Signal. 2014; 12:e002. PMID: 25422592; PMCID: PMC4242289.
      6. Bittencourt D, Lee BH, Gao L, Gerke DS, Stallcup M. Role of distinct surfaces of the G9a ankyrin repeat domain in histone and DNA methylation during embryonic stem cell self-renewal and differentiation. Epigenetics Chromatin. 2014; 7:27. PMID: 25478012; PMCID: PMC4255711.
      7. Schiller BJ, Chodankar R, Watson LC, Stallcup M, Yamamoto KR. Glucocorticoid receptor binds half sites as a monomer and regulates specific target genes. Genome Biol. 2014 Jul 31; 15(7):418. PMID: 25085117; PMCID: PMC4149261.
      8. Ou CY, Chen TC, Lee JV, Wang JC, Stallcup M. Coregulator cell cycle and apoptosis regulator 1 (CCAR1) positively regulates adipocyte differentiation through the glucocorticoid signaling pathway. J Biol Chem. 2014 Jun 13; 289(24):17078-86. PMID: 24811171; PMCID: PMC4059149.
      9. Chodankar R, Wu DY, Schiller BJ, Yamamoto KR, Stallcup M. Hic-5 is a transcription coregulator that acts before and/or after glucocorticoid receptor genome occupancy in a gene-selective manner. Proc Natl Acad Sci U S A. 2014 Mar 18; 111(11):4007-12. PMID: 24591583; PMCID: PMC3964041.
      10. Jeong KW, Andreu-Vieyra C, You JS, Jones PA, Stallcup M. Establishment of active chromatin structure at enhancer elements by mixed-lineage leukemia 1 to initiate estrogen-dependent gene expression. Nucleic Acids Res. 2014 Feb; 42(4):2245-56. PMID: 24288367; PMCID: PMC3936730.
      11. Balasubramaniam S, Comstock CE, Ertel A, Jeong KW, Stallcup M, Addya S, McCue PA, Ostrander WF, Augello MA, Knudsen KE. Aberrant BAF57 signaling facilitates prometastatic phenotypes. Clin Cancer Res. 2013 May 15; 19(10):2657-67. PMID: 23493350; PMCID: PMC3655134.
      12. Hoang T, Fenne IS, Madsen A, Bozickovic O, Johannessen M, Bergsvåg M, Lien EA, Stallcup M, Sagen JV, Moens U, Mellgren G. cAMP response element-binding protein interacts with and stimulates the proteasomal degradation of the nuclear receptor coactivator GRIP1. Endocrinology. 2013 Apr; 154(4):1513-27. PMID: 23462962.
        View in: PubMed
      13. Bittencourt D, Wu DY, Jeong KW, Gerke DS, Herviou L, Ianculescu I, Chodankar R, Siegmund KD, Stallcup M. G9a functions as a molecular scaffold for assembly of transcriptional coactivators on a subset of glucocorticoid receptor target genes. Proc Natl Acad Sci U S A. 2012 Nov 27; 109(48):19673-8. PMID: 23151507; PMCID: PMC3511704.
      14. Purcell DJ, Khalid O, Ou CY, Little GH, Frenkel B, Baniwal SK, Stallcup M. Recruitment of coregulator G9a by Runx2 for selective enhancement or suppression of transcription. J Cell Biochem. 2012 Jul; 113(7):2406-14. PMID: 22389001; PMCID: PMC3350606.
      15. Won Jeong K, Chodankar R, Purcell DJ, Bittencourt D, Stallcup M. Gene-specific patterns of coregulator requirements by estrogen receptor-a in breast cancer cells. Mol Endocrinol. 2012 Jun; 26(6):955-66. PMID: 22543272; PMCID: PMC3355545.
      16. Sharma S, Gerke DS, Han HF, Jeong S, Stallcup M, Jones PA, Liang G. Lysine methyltransferase G9a is not required for DNMT3A/3B anchoring to methylated nucleosomes and maintenance of DNA methylation in somatic cells. Epigenetics Chromatin. 2012 Jan 27; 5(1):3. PMID: 22284370; PMCID: PMC3292817.
      17. Ianculescu I, Wu DY, Siegmund KD, Stallcup M. Selective roles for cAMP response element-binding protein binding protein and p300 protein as coregulators for androgen-regulated gene expression in advanced prostate cancer cells. J Biol Chem. 2012 Feb 03; 287(6):4000-13. PMID: 22174411; PMCID: PMC3281703.
      18. Jeong KW, Kim K, Situ AJ, Ulmer TS, An W, Stallcup M. Recognition of enhancer element-specific histone methylation by TIP60 in transcriptional activation. Nat Struct Mol Biol. 2011 Nov 13; 18(12):1358-65. PMID: 22081016; PMCID: PMC3230772.
      19. Purcell DJ, Jeong KW, Bittencourt D, Gerke DS, Stallcup M. A distinct mechanism for coactivator versus corepressor function by histone methyltransferase G9a in transcriptional regulation. J Biol Chem. 2011 Dec 09; 286(49):41963-71. PMID: 21984853; PMCID: PMC3234941.
      20. Yu EJ, Kim SH, Heo K, Ou CY, Stallcup M, Kim JH. Reciprocal roles of DBC1 and SIRT1 in regulating estrogen receptor a activity and co-activator synergy. Nucleic Acids Res. 2011 Sep 01; 39(16):6932-43. PMID: 21596782; PMCID: PMC3167635.
      21. Lee YH, Stallcup M. Roles of protein arginine methylation in DNA damage signaling pathways is CARM1 a life-or-death decision point? Cell Cycle. 2011 May 01; 10(9):1343-4. PMID: 21445011; PMCID: PMC3117038.
      22. Ou CY, LaBonte MJ, Manegold PC, So AY, Ianculescu I, Gerke DS, Yamamoto KR, Ladner RD, Kahn M, Kim JH, Stallcup M. A coactivator role of CARM1 in the dysregulation of ß-catenin activity in colorectal cancer cell growth and gene expression. Mol Cancer Res. 2011 May; 9(5):660-70. PMID: 21478268; PMCID: PMC3096696.
      23. Lee YH, Bedford MT, Stallcup M. Regulated recruitment of tumor suppressor BRCA1 to the p21 gene by coactivator methylation. Genes Dev. 2011 Jan 15; 25(2):176-88. PMID: 21245169; PMCID: PMC3022263.
      24. Obianyo O, Causey CP, Osborne TC, Jones JE, Lee YH, Stallcup M, Thompson PR. A chloroacetamidine-based inactivator of protein arginine methyltransferase 1: design, synthesis, and in vitro and in vivo evaluation. Chembiochem. 2010 Jun 14; 11(9):1219-23. PMID: 20480486; PMCID: PMC3060404.
      25. Jeong KW, Lee YH, Stallcup M. Recruitment of the SWI/SNF chromatin remodeling complex to steroid hormone-regulated promoters by nuclear receptor coactivator flightless-I. J Biol Chem. 2009 Oct 23; 284(43):29298-309. PMID: 19720835; PMCID: PMC2785560.
      26. Ou CY, Kim JH, Yang CK, Stallcup M. Requirement of cell cycle and apoptosis regulator 1 for target gene activation by Wnt and beta-catenin and for anchorage-independent growth of human colon carcinoma cells. J Biol Chem. 2009 Jul 31; 284(31):20629-37. PMID: 19520846; PMCID: PMC2742827.
      27. Haiman CA, Garcia RR, Hsu C, Xia L, Ha H, Sheng X, Le Marchand L, Kolonel LN, Henderson BE, Stallcup M, Greene GL, Press MF. Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort. BMC Cancer. 2009 Jan 30; 9:43. PMID: 19183483; PMCID: PMC2637888.
      28. Lee YH, Stallcup M. Minireview: protein arginine methylation of nonhistone proteins in transcriptional regulation. Mol Endocrinol. 2009 Apr; 23(4):425-33. PMID: 19164444; PMCID: PMC2667706.
      29. Khalid O, Baniwal SK, Purcell DJ, Leclerc N, Gabet Y, Stallcup M, Coetzee GA, Frenkel B. Modulation of Runx2 activity by estrogen receptor-alpha: implications for osteoporosis and breast cancer. Endocrinology. 2008 Dec; 149(12):5984-95. PMID: 18755791; PMCID: PMC2613062.
      30. Kim JH, Yang CK, Heo K, Roeder RG, An W, Stallcup M. CCAR1, a key regulator of mediator complex recruitment to nuclear receptor transcription complexes. Mol Cell. 2008 Aug 22; 31(4):510-9. PMID: 18722177; PMCID: PMC2562329.
      31. Collins RE, Northrop JP, Horton JR, Lee DY, Zhang X, Stallcup M, Cheng X. The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules. Nat Struct Mol Biol. 2008 Mar; 15(3):245-50. PMID: 18264113; PMCID: PMC2586904.
      32. Yang CK, Kim JH, Ann DK, Stallcup M. Differential regulation of the two transcriptional activation domains of the coiled-coil coactivator CoCoA by sumoylation. BMC Mol Biol. 2008 Jan 25; 9:12. PMID: 18218142; PMCID: PMC2263068.
      33. Rao M, Casimiro MC, Lisanti MP, D'Amico M, Wang C, Shirley LA, Leader JE, Liu M, Stallcup M, Engel DA, Murphy DJ, Pestell RG. Inhibition of cyclin D1 gene transcription by Brg-1. Cell Cycle. 2008 Mar 01; 7(5):647-55. PMID: 18239461.
        View in: PubMed
      34. Lee DY, Ianculescu I, Purcell D, Zhang X, Cheng X, Stallcup M. Surface-scanning mutational analysis of protein arginine methyltransferase 1: roles of specific amino acids in methyltransferase substrate specificity, oligomerization, and coactivator function. Mol Endocrinol. 2007 Jun; 21(6):1381-93. PMID: 17426288; PMCID: PMC2075475.
      35. Chen YH, Yang CK, Xia M, Ou CY, Stallcup M. Role of GAC63 in transcriptional activation mediated by beta-catenin. Nucleic Acids Res. 2007; 35(6):2084-92. PMID: 17344318; PMCID: PMC1874623.
      36. Luo Y, Arita K, Bhatia M, Knuckley B, Lee YH, Stallcup M, Sato M, Thompson PR. Inhibitors and inactivators of protein arginine deiminase 4: functional and structural characterization. Biochemistry. 2006 Oct 03; 45(39):11727-36. PMID: 17002273; PMCID: PMC1808342.
      37. Lee YH, Stallcup M. Interplay of Fli-I and FLAP1 for regulation of beta-catenin dependent transcription. Nucleic Acids Res. 2006; 34(18):5052-9. PMID: 16990252; PMCID: PMC1636430.
      38. Yang CK, Kim JH, Stallcup M. Role of the N-terminal activation domain of the coiled-coil coactivator in mediating transcriptional activation by beta-catenin. Mol Endocrinol. 2006 Dec; 20(12):3251-62. PMID: 16931570; PMCID: PMC1770943.
      39. Kim JH, Yang CK, Stallcup M. Downstream signaling mechanism of the C-terminal activation domain of transcriptional coactivator CoCoA. Nucleic Acids Res. 2006; 34(9):2736-50. PMID: 16717280; PMCID: PMC1464418.
      40. Chen YH, Beischlag TV, Kim JH, Perdew GH, Stallcup M. Role of GAC63 in transcriptional activation mediated by the aryl hydrocarbon receptor. J Biol Chem. 2006 May 05; 281(18):12242-7. PMID: 16513642; PMCID: PMC1770942.
      41. Lee DY, Northrop JP, Kuo MH, Stallcup M. Histone H3 lysine 9 methyltransferase G9a is a transcriptional coactivator for nuclear receptors. J Biol Chem. 2006 Mar 31; 281(13):8476-85. PMID: 16461774; PMCID: PMC1770944.
      42. Luo Y, Knuckley B, Lee YH, Stallcup M, Thompson PR. A fluoroacetamidine-based inactivator of protein arginine deiminase 4: design, synthesis, and in vitro and in vivo evaluation. J Am Chem Soc. 2006 Feb 01; 128(4):1092-3. PMID: 16433522; PMCID: PMC1850713.
      43. Yang CK, Kim JH, Li H, Stallcup M. Differential use of functional domains by coiled-coil coactivator in its synergistic coactivator function with beta-catenin or GRIP1. J Biol Chem. 2006 Feb 10; 281(6):3389-97. PMID: 16344550; PMCID: PMC1626527.
      44. Teyssier C, Ou CY, Khetchoumian K, Losson R, Stallcup M. Transcriptional intermediary factor 1alpha mediates physical interaction and functional synergy between the coactivator-associated arginine methyltransferase 1 and glucocorticoid receptor-interacting protein 1 nuclear receptor coactivators. Mol Endocrinol. 2006 Jun; 20(6):1276-86. PMID: 16322096; PMCID: PMC1626528.
      45. Kim JH, Lee MH, Kim BJ, Kim JH, Han SJ, Kim HY, Stallcup M. Role of aspartate 351 in transactivation and active conformation of estrogen receptor alpha. J Mol Endocrinol. 2005 Dec; 35(3):449-64. PMID: 16326832.
        View in: PubMed
      46. Chen YH, Kim JH, Stallcup M. GAC63, a GRIP1-dependent nuclear receptor coactivator. Mol Cell Biol. 2005 Jul; 25(14):5965-72. PMID: 15988012; PMCID: PMC1168828.
      47. Stojadinovic O, Brem H, Vouthounis C, Lee B, Fallon J, Stallcup M, Merchant A, Galiano RD, Tomic-Canic M. Molecular pathogenesis of chronic wounds: the role of beta-catenin and c-myc in the inhibition of epithelialization and wound healing. Am J Pathol. 2005 Jul; 167(1):59-69. PMID: 15972952; PMCID: PMC1603435.
      48. Teyssier C, Ma H, Emter R, Kralli A, Stallcup M. Activation of nuclear receptor coactivator PGC-1alpha by arginine methylation. Genes Dev. 2005 Jun 15; 19(12):1466-73. PMID: 15964996; PMCID: PMC1151663.
      49. Lee YH, Coonrod SA, Kraus WL, Jelinek MA, Stallcup M. Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination. Proc Natl Acad Sci U S A. 2005 Mar 08; 102(10):3611-6. PMID: 15731352; PMCID: PMC553305.
      50. Li YJ, Stallcup M, Lai MM. Hepatitis delta virus antigen is methylated at arginine residues, and methylation regulates subcellular localization and RNA replication. J Virol. 2004 Dec; 78(23):13325-34. PMID: 15542683; PMCID: PMC524986.
      51. Lee DY, Teyssier C, Strahl BD, Stallcup M. Role of protein methylation in regulation of transcription. Endocr Rev. 2005 Apr; 26(2):147-70. PMID: 15479858.
        View in: PubMed
      52. Kim JH, Stallcup M. Role of the coiled-coil coactivator (CoCoA) in aryl hydrocarbon receptor-mediated transcription. J Biol Chem. 2004 Nov 26; 279(48):49842-8. PMID: 15383530.
        View in: PubMed
      53. Wang Y, Wysocka J, Sayegh J, Lee YH, Perlin JR, Leonelli L, Sonbuchner LS, McDonald CH, Cook RG, Dou Y, Roeder RG, Clarke S, Stallcup M, Allis CD, Coonrod SA. Human PAD4 regulates histone arginine methylation levels via demethylimination. Science. 2004 Oct 08; 306(5694):279-83. PMID: 15345777.
        View in: PubMed
      54. Guerrero-Santoro J, Yang L, Stallcup M, DeFranco DB. Distinct LIM domains of Hic-5/ARA55 are required for nuclear matrix targeting and glucocorticoid receptor binding and coactivation. J Cell Biochem. 2004 Jul 01; 92(4):810-9. PMID: 15211577.
        View in: PubMed
      55. Lee YH, Campbell HD, Stallcup M. Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activity. Mol Cell Biol. 2004 Mar; 24(5):2103-17. PMID: 14966289; PMCID: PMC350567.
      56. Kim JH, Li H, Stallcup M. CoCoA, a nuclear receptor coactivator which acts through an N-terminal activation domain of p160 coactivators. Mol Cell. 2003 Dec; 12(6):1537-49. PMID: 14690606.
        View in: PubMed
      57. Li H, Kim JH, Koh SS, Stallcup M. Synergistic effects of coactivators GRIP1 and beta-catenin on gene activation: cross-talk between androgen receptor and Wnt signaling pathways. J Biol Chem. 2004 Feb 06; 279(6):4212-20. PMID: 14638683.
        View in: PubMed
      58. Stallcup M, Kim JH, Teyssier C, Lee YH, Ma H, Chen D. The roles of protein-protein interactions and protein methylation in transcriptional activation by nuclear receptors and their coactivators. J Steroid Biochem Mol Biol. 2003 Jun; 85(2-5):139-45. PMID: 12943698.
        View in: PubMed
      59. Ma H, Shang Y, Lee DY, Stallcup M. Study of nuclear receptor-induced transcription complex assembly and histone modification by chromatin immunoprecipitation assays. Methods Enzymol. 2003; 364:284-96. PMID: 14631851.
        View in: PubMed
      60. Teyssier C, Chen D, Stallcup M. Requirement for multiple domains of the protein arginine methyltransferase CARM1 in its transcriptional coactivator function. J Biol Chem. 2002 Nov 29; 277(48):46066-72. PMID: 12351636.
        View in: PubMed
      61. Li H, Park S, Kilburn B, Jelinek MA, Henschen-Edman A, Aswad DW, Stallcup M, Laird-Offringa IA. Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase. J Biol Chem. 2002 Nov 22; 277(47):44623-30. PMID: 12237300.
        View in: PubMed
      62. Lee YH, Koh SS, Zhang X, Cheng X, Stallcup M. Synergy among nuclear receptor coactivators: selective requirement for protein methyltransferase and acetyltransferase activities. Mol Cell Biol. 2002 Jun; 22(11):3621-32. PMID: 11997499; PMCID: PMC133819.
      63. Zhou H, Luo MP, Schönthal AH, Pike MC, Stallcup M, Blumenthal M, Zheng W, Dubeau L. Effect of reproductive hormones on ovarian epithelial tumors: I. Effect on cell cycle activity. Cancer Biol Ther. 2002 May-Jun; 1(3):300-6. PMID: 12432283.
        View in: PubMed
      64. Koh SS, Li H, Lee YH, Widelitz RB, Chuong CM, Stallcup M. Synergistic coactivator function by coactivator-associated arginine methyltransferase (CARM) 1 and beta-catenin with two different classes of DNA-binding transcriptional activators. J Biol Chem. 2002 Jul 19; 277(29):26031-5. PMID: 11983685; PMCID: PMC4386649.
      65. Chen SL, Loffler KA, Chen D, Stallcup M, Muscat GE. The coactivator-associated arginine methyltransferase is necessary for muscle differentiation: CARM1 coactivates myocyte enhancer factor-2. J Biol Chem. 2002 Feb 08; 277(6):4324-33. PMID: 11713257.
        View in: PubMed